################################################################################################
# Program: MUSTANG-Lite v0.1: A  Multiple structural alignment algorithm
# Authors: A. S. Konagurthu, A. M. Lesk, J. C. Whisstock, and P. J. Stuckey
# Rundate: Fri Aug 12 22:38:25 2005
# Report_file: /mnt/EXTRA_STORAGE/MUSTANG_RESULTS/MUSTANG_HOMSTRAD/results/kinase.html
################################################################################################
#====================================
# Aligned_structures: 15
#   1: 1a06.pdb
#   2: 1a6o.pdb
#   3: 1b6cb.pdb
#   4: 1blxa.pdb
#   5: 1cdka.pdb
#   6: 1ckia.pdb
#   7: 1csn.pdb
#   8: 1hcl.pdb
#   9: 1jnk.pdb
#  10: 1koa.pdb
#  11: 1koba.pdb
#  12: 1p38.pdb
#  13: 1phk.pdb
#  14: 1tkia.pdb
#  15: 3erk.pdb
#
# Length:        646
# Identity:        8/646 (  1.2%)  (Calculated as the percentage of conserved columns in the alignment.)
# Similarity:     11/646 (  1.7%)  (Calculated as the percentage of semi-conserved columns in the alignment)
# Gaps:          442/646 ( 68.4%)  (Calculated as the percentage of columns with atleast one gap.)

#===========================================ALIGNMENT START=========================================


1a06.pdb                1  ---------------------------W-------------------------KQ-----    3
1a6o.pdb                1  -----SKARVY----ADVNV----LRPKEYWD-YEA-----L--------TVQ--WG---   28
1b6cb.pdb               1  ----T----TL----KDLIY----DMT-TS-----G------------SG-SG---LPLL   22
1blxa.pdb                  ------------------------------------------------------------     
1cdka.pdb               1  KG-------SEQESVKEFLA----KAKEDFLKKW-E-----N---------PAQNTA---   31
1ckia.pdb               1  -------------------------------------------------M-------E--    2
1csn.pdb                   ------------------------------------------------------------     
1hcl.pdb                   ------------------------------------------------------------     
1jnk.pdb                1  --------------------------------------DN--QFYSVEV-GDS---T---   13
1koa.pdb                1  ----------Y----DNYV-FDIWKQYY------------PQ-------P-VEIK-----   20
1koba.pdb               1  ---IN----DY----DKFY-EDIWKKYV------------PQ-------P-VEVK-----   23
1p38.pdb                1  --------------------------------------ER-PTFYRQEL-NKT---I---   14
1phk.pdb                   ------------------------------------------------------------     
1tkia.pdb               1  --K---------------------------------------------------------    1
3erk.pdb                1  ------------------------------------AA------GPEMV-RGQ---V---   11
                                                                                       

1a06.pdb                4  ------AED---IRDIYDFRDVLGTGA-FS-EVILAEDKRT-QKLVAIKCIAK-------   44
1a6o.pdb               29  --------E----QDDYEVVRKVGRG-KY-SEVFEGINVNN-NEKCIIKILKP-------   66
1b6cb.pdb              23  VQR-----TI---ARTIVLQESIGKG-RF-GEVWRGKWR---GEEVAVKIFSS-------   62
1blxa.pdb               1  -----GLCR---ADQQYECVAEIGEG-AY-GKVFKARDLKNGGRFVALKRVRV-QTGEE-   48
1cdka.pdb              32  --------H----LDQFERIKTLGTG-SF-GRVMLVKHKET-GNHFAMKILDK-------   69
1ckia.pdb               3  ----------LRVGNRYRLGRKIGSG-SF-GDIYLGTDIAA-GEEVAIKLECV-------   42
1csn.pdb                1  ----------NVVGVHYKVGRRIGEG-SF-GVIFEGTNLLN-NQQVAIKFEPR-------   40
1hcl.pdb                1  -------------MENFQKVEKIGEG-TY-GVVYKARNKLT-GEVVALKKIR-------T   37
1jnk.pdb               14  ---FT-------VLKRYQNLKPIGSG-AQ-GIVCAAYDAVL-DRNVAIKKLSRPF-----   55
1koa.pdb               21  ------HDH---VLDHYDIHEELGTG-AF-GVVHRVTERAT-GNNFAAKFVMT-------   61
1koba.pdb              24  ------QGS---VYDYYDILEELGSG-AF-GVVHRCVEKAT-GRVFVAKFINT-------   64
1p38.pdb               15  ---WE-------VPERYQNLSPVGSG-AY-GSVCAAFDTKT-GHRVAVKKLSRPF-----   56
1phk.pdb                1  ------------FYENYEPKEILGRG-VS-SVVRRCIHKPT-CKEYAVKIIDV-------   38
1tkia.pdb               2  --------E---LYEKYMIAEDLGRG-EF-GIVHRCVETSS-KKTYMAKFVKV-------   40
3erk.pdb               12  ---FD-------VGPRYTNLSYIGEG-AY-GMVCSAYDNLN-KVRVAIKKISP-F-----   52
                                                  G G                      K           

1a06.pdb               45  -----------------------ENEIAVLHKI--KHPNIVALDDIYESG----------   69
1a6o.pdb               67  --V---------KK---KKIKREIKILQNLC----GGPNIVKLLDIVRDQ-H----S---  100
1b6cb.pdb              63  --R---------E------ERSWFREAEIYQTVMLRHENILGFIAADNKD-NG---T--W   99
1blxa.pdb              49  GM----------PL---STIREVAV-LRHLETF--EHPNVVRLFDVCTVSRT-----DRE   87
1cdka.pdb              70  --Q---------KVVKLKQIEHTLNEKRILQAV--NFPFLVKLEYSFKDN----------  106
1ckia.pdb              43  --K---------T----K-HPQLHIESKIYKMM-QGGVGIPTIRWCGAEG----------   75
1csn.pdb               41  --R---------S----D-APQLRDEYRTYKLL-AGCTGIPNVYYFGQEG----------   73
1hcl.pdb               38  EGV---------PS---TAIRE----ISLLKEL--NHPNIVKLLDVIHTEN---------   70
1jnk.pdb               56  --Q---------NQ---THAKRAYRELVLMKCV--NHKNIISLLNVFTPQKT-LEEF---   95
1koa.pdb               62  --P---------HE---SDKETVRKEIQTMSVL--RHPTLVNLHDAFEDD----------   95
1koba.pdb              65  --P---------YP---LDKYTVKNEISIMNQL--HHPKLINLHDAFEDK----------   98
1p38.pdb               57  --Q---------SI---IHAKRTYRELRLLKHM--KHENVIGLLDVFTPARS-LEEF---   96
1phk.pdb               39  --TGGGSFSAEEVQ---ELREATLKEVDILRKV-SGHPNIIQLKDTYETN----------   82
1tkia.pdb              41  --K----------G---TDQVLVKKEISILNIA--RHRNILHLHESFESM----------   73
3erk.pdb               53  --E---------HQ---TYCQRTLREIKILLRF--RHENIIGINDIIR-APT-IEQM---   91
                                                                                       

1a06.pdb               70  GHLYLIMQLV-SGGE-LFDRIVEK--G--FYTERDASRLIFQVLDAVKYLHDL-------  116
1a6o.pdb              101  KTPSLIFEYV-N-NTDFKVLYP-------TLTDYDIRYYIYELLKALDYCHSQ-------  144
1b6cb.pdb             100  TQLWLVSDYHEH-GS-LFDYLNRY-----TVTVEGMIKLALSTASGLAHLHMEIVGTQGK  152
1blxa.pdb              88  TKLTLVFEHV-D-QD-LTTYLDKV--PEPGVPTETIKDMMFQLLRGLDFLHSH-------  135
1cdka.pdb             107  SNLYMVMEYV-PGGE-MFSHLRRI--G--RFSEPHARFYAAQIVLTFEYLHSL-------  153
1ckia.pdb              76  DYNVMVMELL-G-PS-LEDLFNFC--S-RKFSLKTVLLLADQMISRIEYIHSK-------  122
1csn.pdb               74  LHNVLVIDLL-G-PS-LEDLLDLC--G-RKFSVKTVAMAAKQMLARVQSIHEK-------  120
1hcl.pdb               71  -KLYLVFEFL-H-QD-LKKFMDAS--ALTGIPLPLIKSYLFQLLQGLAFCHSH-------  117
1jnk.pdb               96  QDVYLVMELM-D-AN-LCQVIQ-M-----ELDHERMSYLLYQMLCGIKHLHSA-------  139
1koa.pdb               96  NEMVMIYEFM-SGGE-LFEKV-ADEHN--KMSEDEAVEYMRQVCKGLCHMHEN-------  143
1koba.pdb              99  YEMVLILEFL-SGGE-LFDRI-AAEDY--KMSEAEVINYMRQACEGLKHMHEH-------  146
1p38.pdb               97  NDVYLVTHLM-G-AD-LNNIVKCQ-----KLTDDHVQFLIYQILRGLKYIHSA-------  141
1phk.pdb               83  TFFFLVFDLM-KKGE-LFDYLTEK--V--TLSEKETRKIMRALLEVICALHKL-------  129
1tkia.pdb              74  EELVMIFEFI-SGLD-IFERI-NTSAF--ELNEREIVSYVHQVCEALQFLHSH-------  121
3erk.pdb               92  KDVYIVQDLM-E-TD-LYKLLKTQ-----HLSNDHICYFLYQILRGLKYIHSA-------  136
                                                                             H         

1a06.pdb              117  -GIVHRDLKPENLLYYSLD---EDSKIMISDF----------------------------  144
1a6o.pdb              145  -GIMHRDVKPHNVMIDH-E----LRKLRLIDWGL-----AEFYH-P-G----K----EYN  183
1b6cb.pdb             153  PAIAHRDLKSKNILVKK------NGTCCIADLGL-----AVRHD-SATD---T----IDI  193
1blxa.pdb             136  -RVVHRDLKPQNILVTS------SGQIKLADFG-----LARIYS-F-Q-MAL--TSV---  175
1cdka.pdb             154  -DLIYRDLKPENLLIDQ------QGYIQVTDFGF-----AKRVK-G------R-----T-  188
1ckia.pdb             123  -NFIHRDVKPDNFLMGL-G-KK-GNLVYIIDFGL-----AKKYRDARTH---Q----HIP  166
1csn.pdb              121  -SLVYRDIKPDNFLIGRPNSKN-ANMIYVVDFGM-----VKFYRDPVTK---Q----HIP  166
1hcl.pdb              118  -RVLHRDLKPQNLLINT------EGAIKLADFG-LARAFGVPVR--------TYTHE---  158
1jnk.pdb              140  -GIIHRDLKPSNIVVKS------DCTLKILDFGLA----SFMMT----------P-Y---  174
1koa.pdb              144  -NYVHLDLKPENIMFTTKR----SNELKLIDFGL-----TAHLD-P-K----Q----SVK  183
1koba.pdb             147  -SIVHLDIKPENIMCETKK----ASSVKIIDFGL-----ATKLN-P-D----E----IVK  186
1p38.pdb              142  -DIIHRDLKPSNLAVNE------DCELKILDFGL-----ARHTD----------D-EM--  176
1phk.pdb              130  -NIVHRDLKPENILLDD------DMNIKLTDFGF-----SCQLD-P-G----E----KLR  167
1tkia.pdb             122  -NIGHFDIRPENIIYQTRR----SSTIKIIEFGQ-----ARQLK-P-G----D----NFR  161
3erk.pdb              137  -NVLHRDLKPSNLLLNT------TCDLKICDFGL-----ARVAD-P-D----H----DHT  174
                                 D kp N                  d                             

1a06.pdb              145  -----------PGYVAPEVLAQ------K-P------YSKAVDCWSIGVIAYILLCG---  177
1a6o.pdb              184  ------VRVASRYFKGPELLVD------LQD------YDYSLDMWSLGCMFAGMIFR---  222
1b6cb.pdb             194  -A-PN-HRVGTKRYMAPEVLDD------S-INMKHFESFKRADIYAMGLVFWEIARRCSI  243
1blxa.pdb             176  --------VVTLWYRAPEVLLQ------S-S------YATPVDLWSVGCIFAEMFRR---  211
1cdka.pdb             189  ----W-TLCGTPEYLAPEIILS------K-G------YNKAVDWWALGVLIYEMAAG---  227
1ckia.pdb             167  -YRENKNLTGTARYASINTHLG------I-E------QSRRDDLESLGYVLMYFNLG---  209
1csn.pdb              167  -YREKKNLSGTARYMSINTHLG------R-E------QSRRDDLEALGHVFMYFLRG---  209
1hcl.pdb              159  --------VVTLWYRAPEILLG------CKY------YSTAVDIWSLGCIFAEMVTR---  195
1jnk.pdb              175  --------VVTRYYRAPEVILG------M-G------YKENVDIWSVGCIMGEMVRH---  210
1koa.pdb              184  ------VTTGTAEFAAPEVAEG------K-P------VGYYTDMWSVGVLSYILLSG---  221
1koba.pdb             187  ------VTTATAEFAAPEIVDR------E-P------VGFYTDMWAIGVLGYVLLSG---  224
1p38.pdb              177  -T--GY--VATRWYRAPEIMLN-----WM-H------YNQTVDIWSVGCIMAELLTG---  216
1phk.pdb              168  ------EVCGTPSYLAPEIIECSMNDNHP-G------YGKEVDMWSTGVIMYTLLAG---  211
1tkia.pdb             162  ------LLFTAPEYYAPEVHQH------D-V------VSTATDMWSLGTLVYVLLSG---  199
3erk.pdb              175  GF--LTEYVATRWYRAPEIMLN------S-K-G----YTKSIDIWSVGCILAEMLSN---  217
                                                                     D    G            

1a06.pdb              178  -------Y-PPFY-------D-E----NDAKLFEQIL-KAEY------------------  198
1a6o.pdb              223  -------KEPFFY-------G-H----DNHDQLVKIA-KV-----LGTDGLNVYLN----  253
1b6cb.pdb             244  GGIHEDYQ-LPYYDLVPSD---P----SVEEMRKVVCEQKLRPNI---------------  280
1blxa.pdb             212  -------K-PLFR-------G-S----SDVDQLGKIL-DV-----IGLP-GEEDWP-R--  241
1cdka.pdb             228  -------Y-PPFF-------A-D----QPIQIYEKIV-SGKV------------------  248
1ckia.pdb             210  -------S-LPWQ-----G---L----KYERISEKKM-ST-----P--------------  229
1csn.pdb              210  -------S-LPWQ-----GLKAATNKQKYERIGEKKQ-ST-----P--------------  236
1hcl.pdb              196  -------R-ALFP-------G-D----SEIDQLFRIF-RT-----LGTP-DEVV--WPGV  226
1jnk.pdb              211  -------K-ILFP-------G-R----DYIDQWNKVI-EQ-----LGTP-CPEFMK----  239
1koa.pdb              222  -------L-SPFG-------G-E----NDDETLRNVK-SCDW------------------  242
1koba.pdb             225  -------L-SPFA-------G-E----DDLETLQNVK-RCDW------------------  245
1p38.pdb              217  -------R-TLFP-------G-T----DHIDQLKLIL-RL-----VGTP-GAELLK----  245
1phk.pdb              212  -------S-PPFW-------H-R----KQMLMLRMIM-SGNY------------------  232
1tkia.pdb             200  -------I-NPFL-------A-E----TNQQIIENIM-NAEY------------------  220
3erk.pdb              218  -------R-PIFP-------G-K----HYLDQLNHIL-GI-----LGSP-SQEDLN----  246
                                                                                       

1a06.pdb              199  ------------------------EF-DSPYW----D-D------------I-SDSAKDF  215
1a6o.pdb              254  -KYRIELDPQ---LEALVGRHSRKPW--LKFMNADNQHL------------V-SPEAIDF  294
1b6cb.pdb             281  -------------------------PN--RWQ----S-C------------EALRVMAKI  296
1blxa.pdb             242  -DVA---L-----PRQAFHSKSAQPI--EKFV----T-D------------I-DELGKDL  272
1cdka.pdb             249  ------------------------RF-----P----S-H------------F-SSDLKDL  261
1ckia.pdb             230  -------------------------I--EVLC----K-G------------Y-PSEFATY  244
1csn.pdb              237  -------------------------L--RELC----A-G------------F-PEEFYKY  251
1hcl.pdb              227  TSMP---D-----YKPSFPKWARQDF--SKVV----P-P------------L-DEDGRSL  258
1jnk.pdb              240  -KLQ----PTVRNYVENRPKYAGLTF--PKLF----P-DSLFPADSEHNKLK-ASQARDL  286
1koa.pdb              243  ------------------------NM-DDSAF----S-G------------I-SEDGKDF  259
1koba.pdb             246  ------------------------EF-DEDAF----S-S------------V-SPEAKDF  262
1p38.pdb              246  -KIS---SESARNYIQSLAQMPKMNF--ANVF----I-G------------A-NPLAVDL  281
1phk.pdb              233  ------------------------QF-GSPEW----D-D------------Y-SDTVKDL  249
1tkia.pdb             221  ------------------------TF-DEEAF----K-E------------I-SIEAMDF  237
3erk.pdb              247  -CII---NLKARNYLLSLPHKNKVPW--NRLF----P-N------------A-DSKALDL  282
                                                                                       

1a06.pdb              216  IRHLME-KDPEKR-FT-----CEQALQHPWIAG-D--TA-LDK-NIHQS-----------  252
1a6o.pdb              295  LDKLLR-YDHQER-LT-----ALEAMTHPYFQQ-V--------------------R---A  323
1b6cb.pdb             297  MRECWY-ANGAAR-LT-----ALRIKKT-LSQL-S-------------QQEG--------  326
1blxa.pdb             273  LLKCLT-FNPAKR-IS-----AYSALSHPYFQD-L--------------------E---R  301
1cdka.pdb             262  LRNLLQ-VDLTKR-FGNLKDGVNDIKNHKWFAT-T--------------------D---W  295
1ckia.pdb             245  LNFCRSLRF--DDKPD-----YSYLRQL-FRNL-F-------------HRQGFSYDYVFD  282
1csn.pdb              252  MHYARNLAF--DATPD-----YDYLQGL-FSKV-L-------------ERLNTTEDENFD  289
1hcl.pdb              259  LSQMLH-YDPNKR-IS-----AKAALAHPFFQD-V--------------------T---K  287
1jnk.pdb              287  LSKMLV-IDPAKR-IS-----VDDALQHPYINV-W----------------Y---D---P  316
1koa.pdb              260  IRKLLL-ADPNTR-MT-----IHQALEHPWLTPGN--APGRDSQIPSSR-----------  299
1koba.pdb             263  IKNLLQ-KEPRKR-LT-----VHDALEHPWLKG-D--HSNLTSRIPSSR-----------  301
1p38.pdb              282  LEKMLV-LDSDKR-IT-----AAQALAHAYFAQ-Y----------------H---D---P  311
1phk.pdb              250  VSRFLV-VQPQKR-YT-----AEEALAHPFFQQ-Y-------------------------  276
1tkia.pdb             238  VDRLLV-KERKSR-MT-----ASEALQHPWLKQ-KIERV-STKVIRTLK-----------  277
3erk.pdb              283  LDKMLT-FNPHKR-IE-----VEQALAHPYLEQ-Y----------------Y---D---P  312
                                                                                       

1a06.pdb              253  VSEQIKK----NFAK---------------------------------------------  263
1a6o.pdb              324  ------------------------------------A---ENS-----------------  327
1b6cb.pdb                  ------------------------------------------------------------     
1blxa.pdb             302  -C--------------KEN-----------------------------------------  305
1cdka.pdb             296  -IAIYQRKVEA---PFIPKFKGPGD---TSNFDD----------------YEEEEIRVSI  332
1ckia.pdb             283  ------------------------------------WNML----KFGASR----------  292
1csn.pdb              290  ------------------------------------WNLL--------------------  293
1hcl.pdb              288  -P--V-----------PHLR----------------------------------------  293
1jnk.pdb              317  -AEVEA----P----P---P----Q---L-----------DER-E-----HTI-------  333
1koa.pdb              300  YTKIRDS----IKT----------------------K---YDAWP------EP-------  317
1koba.pdb             302  YNKIRQK----IKE----------------------K---YADWP------AP-------  319
1p38.pdb              312  -DDEPV----A----D---P-----Y-DQ------SF---ESR-D-----LLI-------  331
1phk.pdb                   ------------------------------------------------------------     
1tkia.pdb             278  HRRYYHT----LIKK----------------------------DL------NM-------  292
3erk.pdb              313  -SDEPI----A----E---A-----PFKF-----DM----ELD-D-----LPK-------  333
                                                                                       

1a06.pdb              264  ---------SKW----KQAFNAT--AVVRHM---------------  279
1a6o.pdb                   ----------------------------------------------     
1b6cb.pdb                  ----------------------------------------------     
1blxa.pdb                  ----------------------------------------------     
1cdka.pdb             333  NEK----CGKEFSEF-------------------------------  343
1ckia.pdb                  ----------------------------------------------     
1csn.pdb                   ----------------------------------------------     
1hcl.pdb              294  ------------------------------------L---------  294
1jnk.pdb              334  ---E-EWKELIYKEVM---------N--------------------  346
1koa.pdb              318  ----LPPLGRIS----NYSS-LRKHRPQEYS-IRDA-FWDRSEA--  350
1koba.pdb             320  ----QPAIGRIA----NFSS-LRKHRPQEYQ-IYDS-YFDRKEAV-  353
1p38.pdb              332  ---D-EWKSLTYDEVI---------S--FVP-PPLD----------  351
1phk.pdb              277  ---------------------------------------------V  277
1tkia.pdb             293  ----VVSAARIS----CGGA-IR--SQKGVS-VAKV-KVASI----  321
3erk.pdb              334  ---E-KLKELIFEETA---------R--FQPG--------------  350
                                                                         


#=========================================ALIGNMENT END=============================================
#LEGEND:
#
# Colours indicate the chemical nature of the amino acid;
# Red         = small hydrophobic including aromatic,{A,F,I,L,M,P,V,W}
# Blue        = Acidic,{D,E}
# Magenta     = Basic,{K,R} and
# Green       = Basic amino acids with hydroxyl groups and/or amine groups {C,G,H,N,Q,S,T,Y}.
#
# The "markup row" below each stretch of the multiple alignment is used to mark completely conserved
# residue (denoted in UPPERCASE) and semi-conserved reside ( denoted in lowercase) in a column of the alignment.
#
################################################EOF#################################################