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# Program: MUSTANG-Lite v0.1: A Multiple structural alignment algorithm
# Authors: A. S. Konagurthu, A. M. Lesk, J. C. Whisstock, and P. J. Stuckey
# Rundate: Sat Jul 23 19:59:33 2005
# Report_file: /mnt/EXTRA_STORAGE/MUSTANG_RESULTS/HOMSTRAD_Datasets/results/serpin.html
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#====================================
# Aligned_structures: 8
# 1: 1a7ca.pdb
# 2: 1atha.pdb
# 3: 1atta.pdb
# 4: 1hle.pdb
# 5: 1ovaa.pdb
# 6: 1qlpa.pdb
# 7: 1sek.pdb
# 8: 2ach.pdb
#
# Length: 438
# Identity: 28/438 ( 6.4%) (Calculated as the percentage of conserved columns in the alignment.)
# Similarity: 52/438 ( 11.9%) (Calculated as the percentage of semi-conserved columns in the alignment)
# Gaps: 104/438 ( 23.7%) (Calculated as the percentage of columns with atleast one gap.)
#===========================================ALIGNMENT START=========================================
1a7ca.pdb 1 ---HHPPSYVAHLASDFGVRVFQQVAQAS-KDRNVVFSPYGVASVLAMLQLTTGGETQQQ 56
1atha.pdb 1 ----RRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQ 56
1atta.pdb 1 ---NRRVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQ 57
1hle.pdb 1 ------MEQLSTANTHFAVDLFRALNESD-PTGNIFISPLSISSALAMIFLGTRGNTAAQ 53
1ovaa.pdb 1 --G-----SIGAASMEFCFDVFKELKVHH-ANENIFYCPIAIMSALAMVYLGAKDSTRTQ 52
1qlpa.pdb 1 --F----NKITPNLAEFAFSLYRQLAHQS-NSTNIFFSPVSIATAFAMLSLGTKADTHDE 53
1sek.pdb 1 GE-TDLQKILRESNDQFTAQMFSEVVKAN-PGQNVVLSAFSVLPPLGQLALASVGESHDE 58
2ach.pdb 1 -------LGLASANVDFAFSLYKQLVLKA-PDKNVIFSPLSISTALAFLSLGAHNTTLTE 52
F N sp a L t
1a7ca.pdb 57 IQAAMGFKI----D----DKGM------APALRHLYKELMGPW--NKDEISTTDAIFVQR 100
1atha.pdb 57 LMEVFKFD-TISEK--T-SDQI------HFFFAKLNCRLYR-----SSKLVSANRLFGDK 101
1atta.pdb 58 LMEVFKFD-TISEK--T-SDQI------HFFFAKLNCRLYRKA-NKSSELVSANRLFGDK 106
1hle.pdb 54 VSKALYFD-TVED--------I------HSRFQSLNADINKPG-A-PYILKLANRLYGEK 96
1ovaa.pdb 53 INKVVRFD-KLPGFGDSIEAQCGTSVNVHSSLRDILNQITKPN--DVYSFSLASRLYAEE 109
1qlpa.pdb 54 ILEGLNFNL--TEI--P-EAQI------HEGFQELLRTLNQPD--SQLQLTTGNGLFLSE 100
1sek.pdb 59 LLRALALPN---------DNVT------KDVFADLNRGVR---AVKGVDLKMASKIYVAK 100
2ach.pdb 53 ILKGLKFNL--TET--S-EAEI------HQSFQHLLRTLNQSS--DELQLSMGNAMFVKE 99
f l
1a7ca.pdb 101 DLKLVQGFMPHFFRLFRSTVKQVDF-SEVERARFIINDWVKTHTKGMISNLLGKGAVDQL 159
1atha.pdb 102 SLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINEL 161
1atta.pdb 107 SITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEF 166
1hle.pdb 97 TYNFLADFLASTQKMYGAELASVDFQQAPEDARKEINEWVKGQTEGKIPELLVKGMVDNM 156
1ovaa.pdb 110 RYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQ 169
1qlpa.pdb 101 GLKLVDKFLEDVKKLYHSEAFTVNFG-DTEEAKKQINDYVEKGTQGKIVDLVKE--LDRD 157
1sek.pdb 101 GLELNDDFAAVSRDVFGSEVQNVDF-VKSVEAAGAINKWVEDQTNNRIKNLVDPDALDET 159
2ach.pdb 100 QLSLLDRFTEDAKRLYGSEAFATDFQ-DSAAAKKLINDYVKNGTRGKITDLIKD--LDSQ 156
F IN v T g I
1a7ca.pdb 160 TRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQT-NKFNYTEFTTPDGH 218
1atha.pdb 162 TVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQE-GKFRYRRV-A-E-- 216
1atta.pdb 167 TVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQE-SKFRYRRV-A-E-- 221
1hle.pdb 157 TKLVLVNAIYFKGNWQQKFMKEATRDAPFRLNKKDTKTVKMMYQK-KKFPYNYIED-L-- 212
1ovaa.pdb 170 TAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQI-GLFRVASMAS-E-- 225
1qlpa.pdb 158 TVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRL-GMFNIQHCKK-L-- 213
1sek.pdb 160 TRSVLVNAIYFKGSWKDKFNKERTMDRDFHVSKDKTIKVPTMIGK-KDVRYADVPE-L-- 215
2ach.pdb 157 TMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEE-L-- 213
T vLVN i Fkg W F T F v mM
1a7ca.pdb 219 YYDILELPYHGDTLSMFIAAPYEK---E-VPLSALTNIL-SAQLISHWKG--NMT-RLPR 270
1atha.pdb 217 GTQVLELPFKGDDITMVLILPKPE---K-SL-AKVEKEL-TPEVLQEWLD--ELE-EMML 267
1atta.pdb 222 STQVLELPFKGDDITMVLILPKLE---K-TL-AKVEQEL-TPDMLQEWLD--ELT-ETLL 272
1hle.pdb 213 KCRVLELPYQGKELSMIILLPDDIEDESTGL-EKIEKQL-TLDKLREWTKPENLY-LAEV 269
1ovaa.pdb 226 KMKILELPFASGTMSMLVLLPDEV---S-GL-EQLESII-NFEKLTEWTSSNVME-ERKI 278
1qlpa.pdb 214 SSWVLLMKYLG-NATAIFFLPDE----G-KL-QHLENEL-THDIITKFLE--NED-RRSA 262
1sek.pdb 216 DAKMIEMSYEGDQASMIIILPNQV---D-GI-TALEQKLKDPKALSRAEE--RLY-NTEV 267
2ach.pdb 214 SCTVVELKYTG-NASALFILPDQ----D-KM-EEVEAML-LPETLKRWRD--SLEFREIG 263
e g lP e l
1a7ca.pdb 271 LLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLS---D-QEPLHVAQALQKVKIE 326
1atha.pdb 268 VVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIV-AEG-RDDLYVSDAFHKAFLE 325
1atta.pdb 273 VVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAE-G-RSDLYVSDAFHKAFLE 330
1hle.pdb 270 NVHLPRFKLEESYDLTSHLARLGVQDLFNRGKADLSGMS---G-ARDLFVSKIIHKSFVD 325
1ovaa.pdb 279 KVYLPRMKMEEKYNLTSVLMAMGITDVFSS-SANLSGIS---S-AESLKISQAVHAAHAE 333
1qlpa.pdb 263 SLHLPKLSITGTYDLKSVLGQLGITKVFSN-GADLSGVT---E-EAPLKLSKAVHKAVLT 317
1sek.pdb 268 EIYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARLENLL---KTKESLYVDAAIQKAFIE 324
2ach.pdb 264 ELYLPKFSISRDYNLNDILLQLGIEEAFTS-KADLSGIT---G-ARNLAVSQVVHKAVLD 318
P l L g F l L k
1a7ca.pdb 327 VNESGT------------------------------------A-PEEIIMDRPFLFVVRH 349
1atha.pdb 326 VNEEGSEAAAST--AV---VIAG------RS--------LNPN-RVTFKANRPFLVFIRE 365
1atta.pdb 331 VNEEGSEAA-----AS---TVIS------IA--------GRS--RVTFKANRPFLVLIRE 366
1hle.pdb 326 LNEEGTEAA-----AA---TAGT------IL--------L-A--EENFNADHPFIFFIRH 360
1ovaa.pdb 334 INEA-------G--RE-----VVG-----SAEAGVDAAS--V--SEEFRADHPFLFCIKH 370
1qlpa.pdb 318 IDEKGTEAA-----GA---MFLE------AI--------P-MSIPPEVKFNKPFVFLMIE 354
1sek.pdb 325 VNEE-------GAEAAAAN--AFKITTYS---------F--HF-VPKVEINKPFFFSLKY 363
2ach.pdb 319 VFEEGTEAS-----AA---TAVK------IT--------L-LT-RTIVRFNRPFLMIIVP 354
E PF
1a7ca.pdb 350 NPTGTVLFMGQVMEP--- 364
1atha.pdb 366 VPLNTIIFMGRVANPCV- 382
1atta.pdb 367 VALNTIIFMGRVANPCVD 384
1hle.pdb 361 NPSANILFLGRFSSP--- 375
1ovaa.pdb 371 IATNAVLFFGRCVSP--- 385
1qlpa.pdb 355 QNTKSPLFMGKVVNPTQK 372
1sek.pdb 364 --NRNSMFSGVCVQP--- 376
2ach.pdb 355 TDTQNIFFMSKVTNPKQA 372
F g P
#=========================================ALIGNMENT END=============================================
#LEGEND:
#
# Colours indicate the chemical nature of the amino acid;
# Red = small hydrophobic including aromatic,{A,F,I,L,M,P,V,W}
# Blue = Acidic,{D,E}
# Magenta = Basic,{K,R} and
# Green = Basic amino acids with hydroxyl groups and/or amine groups {C,G,H,N,Q,S,T,Y}.
#
# The "markup row" below each stretch of the multiple alignment is used to mark completely conserved
# residue (denoted in UPPERCASE) and semi-conserved reside ( denoted in lowercase) in a column of the alignment.
#
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