4gsb:A (HIS59) to (SER264) MONOCLINIC CRYSTAL FORM OF THE APO-ERK2 | KINASE, TRANSFERASE
4wd5:B (SER752) to (ASP974) CRYSTAL STRUCTURE OF EGFR 696-1022 T790M IN COMPLEX WITH QL-X138 | EGFR, T790M, GATEKEEPER MUTATION, INHIBITOR, TRANSFERASE-INHIBITOR COMPLEX
3e8e:I (GLN84) to (ALA298) CRYSTAL STRUCTURES OF THE KINASE DOMAIN OF PKA IN COMPLEX WITH ATP- COMPETITIVE INHIBITORS | PKA, AKT2, KINASE, PKI, BOVINE, INHIBITOR, ATP-BINDING, CAMP, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2oiq:B (SER303) to (TYR519) CRYSTAL STRUCTURE OF CHICKEN C-SRC KINASE DOMAIN IN COMPLEX WITH THE CANCER DRUG IMATINIB. | SRC,KINASE,IMATINIB,INACTIVE, TRANSFERASE
2onl:D (CYS98) to (GLN327) CRYSTAL STRUCTURE OF THE P38A-MAPKAP KINASE 2 HETERODIMER | HETERODIMER, KINASE, NLS, NES, DOCKING GROOVE, TRANSFERASE
3eh9:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DEATH ASSOCIATED PROTEIN KINASE COMPLEXED WITH ADP | KINASE CATALYTIC DOMAIN GLYCINE-RICH LOOP, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3eha:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DEATH ASSOCIATED PROTEIN KINASE COMPLEXED WITH AMPPNP | KINASE DOMAIN S/T KINASE, ANK REPEAT, APOPTOSIS, ATP- BINDING, CALMODULIN-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE
3ej1:C (PRO45) to (HIS283) CDK2/CYCLINA COMPLEXED WITH A PYRAZOLOPYRIDAZINE INHIBITOR | CDK, CYCLIN, KINASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, NUCLEUS, TRANSFERASE-CELL CYCLE COMPLEX
3el8:A (PRO304) to (TYR519) CRYSTAL STRUCTURE OF C-SRC IN COMPLEX WITH PYRAZOLOPYRIMIDINE 5 | C-SRC, KINASE, PYRAZOLOPYRIMIDINE 5, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3eoc:C (PRO45) to (HIS283) CDK2/CYCLINA COMPLEXED WITH A IMIDAZO TRIAZIN-2-AMINE | CDK, CYCLIN, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, NUCLEUS, TRANSFERASE-CELL CYCLE COMPLEX
2bfx:A (GLU135) to (HIS340) MECHANISM OF AURORA-B ACTIVATION BY INCENP AND INHIBITION BY HESPERADIN. | TRANSFERASE, KINASE, MITOSIS, INHIBITION, TRANSFERASE COMPLEX
2bfy:A (VAL134) to (HIS340) COMPLEX OF AURORA-B WITH INCENP AND HESPERADIN. | TRANSFERASE, KINASE, MITOSIS, INHIBITION, TRANSFERASE COMPLEX
1bkx:A (GLN84) to (HIS294) A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY | CONFORMATIONAL CHANGES, ELECTROSTATIC COMPLEMENTARITY, PHOSPHORYLATION, PROTEIN KINASE, TRANSFERASE, COMPLEX (PHOSPHOTRANSFERASE/ADENOSINE), PHOSPHOTRANSFERASE
2bpm:A (PRO45) to (GLN287) STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529 | PROTEIN KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, CELL DIVISION, CYCLIN
3f5p:A (SER1040) to (SER1265) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:B (SER1040) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:C (SER1040) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:D (SER1040) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:K (SER1040) to (SER1265) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:M (SER1040) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:S (SER1040) to (SER1265) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:T (SER1040) to (SER1265) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f6x:D (SER303) to (TYR519) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3s95:A (GLU375) to (HIS614) CRYSTAL STRUCTURE OF THE HUMAN LIMK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, LIM DOMAIN KINASE, TRANSFERASE-ANTIBIOTIC COMPLEX
3fc2:A (LYS91) to (THR306) PLK1 IN COMPLEX WITH BI6727 | PROTEIN KINASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4xbr:A (ARG360) to (HIS569) IN CELLULO CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INKA | PAK4, INKA, CRYSTALLIZATION, TRANSFERASE
1oec:A (THR524) to (THR764) FGFR2 KINASE DOMAIN | TRANSFERASE, FGFR2 KINASE DOMAIN, RECEPTOR TYROSINE KINASE,
1oi9:A (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1oiu:C (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1oiy:A (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
4xj0:A (GLN62) to (HIS310) CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH AN INHIBITOR 14K | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xj0:B (GLN62) to (HIS310) CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH AN INHIBITOR 14K | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4i3z:A (PRO45) to (GLN287) STRUCTURE OF PCDK2/CYCLINA BOUND TO ADP AND 2 MAGNESIUM IONS | ADP AND MAGNESIUM BINDING, T160 PHOSPHORYLATION, TRANSFERASE-CELL CYCLE COMPLEX
4i3z:C (PRO45) to (GLN287) STRUCTURE OF PCDK2/CYCLINA BOUND TO ADP AND 2 MAGNESIUM IONS | ADP AND MAGNESIUM BINDING, T160 PHOSPHORYLATION, TRANSFERASE-CELL CYCLE COMPLEX
1okw:A (PRO45) to (GLN287) CYCLIN A BINDING GROOVE INHIBITOR AC-ARG-ARG-LEU-ASN-(M-CL-PHE)-NH2 | CELL CYCLE, COMPLEX(KINASE-CYCLIN), CYCLIN A, LIGAND EXCHANGE, PEPTIDOMIMETICS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1okw:C (PRO45) to (HIS283) CYCLIN A BINDING GROOVE INHIBITOR AC-ARG-ARG-LEU-ASN-(M-CL-PHE)-NH2 | CELL CYCLE, COMPLEX(KINASE-CYCLIN), CYCLIN A, LIGAND EXCHANGE, PEPTIDOMIMETICS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1okv:C (PRO45) to (GLN287) CYCLIN A BINDING GROOVE INHIBITOR H-ARG-ARG-LEU-ILE-PHE-NH2 | KINASE-CYCLIN COMPLEX, CYCLIN A, INHIBITOR, LIGAND EXCHANGE, DRUG DESIGN, PEPTIDOMIMETICS, CELL CYCLE, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1ol1:A (PRO45) to (GLN287) CYCLIN A BINDING GROOVE INHIBITOR H-CIT-CIT-LEU-ILE-(P-F-PHE)-NH2 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, CELL CYCLE, KINASE-CYCLIN COMPLEX, CYCLIN A, INHIBITOR, LIGAND EXCHANGE, DRUG DESIGN, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, CELL DIVISION, MITOSIS, PHOSPHORYLATION, PEPTIDOMIMETICS
1ol1:C (PRO45) to (GLN287) CYCLIN A BINDING GROOVE INHIBITOR H-CIT-CIT-LEU-ILE-(P-F-PHE)-NH2 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, CELL CYCLE, KINASE-CYCLIN COMPLEX, CYCLIN A, INHIBITOR, LIGAND EXCHANGE, DRUG DESIGN, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, CELL DIVISION, MITOSIS, PHOSPHORYLATION, PEPTIDOMIMETICS
1ol2:A (PRO45) to (GLN287) CYCLIN A BINDING GROOVE INHIBITOR H-ARG-ARG-LEU-ASN-(P-F-PHE)-NH2 | CELL CYCLE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, CYCLIN A, LIGAND EXCHANGE, PEPTIDOMIMETICS, KINASE
2pvy:C (THR524) to (THR764) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K659N MUTATION RESPONSIBLE FOR AN UNCLASSIFIED CRANIOSYNOSTOSIS SYNDROME. | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
4i5m:A (LYS91) to (GLN307) SELECTIVE & BRAIN-PERMEABLE POLO-LIKE KINASE-2 (PLK-2) INHIBITORS THAT REDUCE -SYNUCLEIN PHOSPHORYLATION IN RAT BRAIN | POLO-LIKE KINASE-2 (PLK-2), SYNUCLEIN, PARKINSON'S DISEASE, KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2pwl:A (LYS526) to (THR764) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549H MUTATION RESPONSIBLE FOR CROUZON SYNDROME. | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2pwl:B (THR524) to (THR765) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549H MUTATION RESPONSIBLE FOR CROUZON SYNDROME. | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
4i6f:A (HIS122) to (HIS331) SELECTIVE & BRAIN-PERMEABLE POLO-LIKE KINASE-2 (PLK-2) INHIBITORS THAT REDUCE -SYNUCLEIN PHOSPHORYLATION IN RAT BRAIN | POLO-LIKE KINASE-2 (PLK-2), SYNUCLEIN, PARKINSONS DISEASE, KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2c4g:A (PRO45) to (HIS283) STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514 | PROTEIN KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, CELL DIVISION, CYCLIN, ATP-BINDING, CELL CYCLE, MITOSIS, NUCLEOTIDE-BINDING, POLYMORPHISM
2c4g:C (PRO45) to (HIS283) STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514 | PROTEIN KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, CELL DIVISION, CYCLIN, ATP-BINDING, CELL CYCLE, MITOSIS, NUCLEOTIDE-BINDING, POLYMORPHISM
2py3:A (THR524) to (THR765) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565G MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2py3:B (GLU525) to (ASN766) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565G MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2c5o:C (PRO45) to (GLN287) DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN | DIFFERENTIAL INHIBITION, TRANSFERASE, CDK2, ATP-BINDING, CELL CYCLE, CELL DIVISION, POLYMORPHISM, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN, KINASE, MITOSIS, CYCLIN
2c5n:A (PRO45) to (GLN287) DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN | DIFFERENTIAL INHIBITION, TRANSFERASE, CDK2, ATP-BINDING, CELL CYCLE, CELL DIVISION, POLYMORPHISM, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN, KINASE, MITOSIS, CYCLIN
2pzp:A (THR524) to (ASN766) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K526E MUTATION RESPONSIBLE FOR CROUZON SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2pzp:B (GLU526) to (ASN766) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K526E MUTATION RESPONSIBLE FOR CROUZON SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2pzr:A (THR524) to (THR765) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K641R MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2c5v:A (PRO45) to (GLN287) DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN | ATP-BINDING, CELL CYCLE, CELL DIVISION, COMPLEX (KINASE/CYCLIN), CYCIN A, CYCLIN, DRUG DESIGN, LIGAND EXCHANGE, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, COMPLEX (TRANSFERASE/CYCLIN)
2c5v:C (PRO45) to (GLN287) DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN | ATP-BINDING, CELL CYCLE, CELL DIVISION, COMPLEX (KINASE/CYCLIN), CYCIN A, CYCLIN, DRUG DESIGN, LIGAND EXCHANGE, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, COMPLEX (TRANSFERASE/CYCLIN)
2c5x:A (PRO45) to (GLN287) DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN | TRANSFERASE/INHIBITOR, INHIBITION, ACTIVE, INACTIVE, CDK2, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, COMPLEX (TRANSFERASE/INHIBITOR)
2pzy:A (PRO99) to (HIS322) STRUCTURE OF MK2 COMPLEXED WITH COMPOUND 76 | MK2, PROTEIN KINASE, TRANSFERASE
2pzy:B (PRO99) to (LYS307) STRUCTURE OF MK2 COMPLEXED WITH COMPOUND 76 | MK2, PROTEIN KINASE, TRANSFERASE
1cmk:E (GLN84) to (HIS294) CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP- DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS | PHOSPHOTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2q0b:B (THR524) to (ASN766) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565A MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2c6t:A (PRO45) to (GLN287) CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR | SERINE/THREONINE PROTEIN KINASE, CDK2, ATP-BINDING, CELL CYCLE, MITOSIS, PHOSPHORYLATION, TRIAZOLOPYRIMIDINE INHIBITOR, COMPLEX (TRANSFERASE/CYCLIN2)
2c6t:C (PRO45) to (GLN287) CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR | SERINE/THREONINE PROTEIN KINASE, CDK2, ATP-BINDING, CELL CYCLE, MITOSIS, PHOSPHORYLATION, TRIAZOLOPYRIMIDINE INHIBITOR, COMPLEX (TRANSFERASE/CYCLIN2)
4idt:B (ARG437) to (GLY659) CRYSTAL STRUCTURE OF NIK WITH 11-BROMO-5,6,7,8-TETRAHYDROPYRIMIDO[4', 5':3,4]CYCLOHEPTA[1,2-B]INDOL-2-AMINE (T28) | NIK, NUCLEAR FACTOR (NF)-KB, P100 PROCESSING, 2-AMINOPYRIMIDINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4idv:A (ALA438) to (GLY659) CRYSTAL STRUCTURE OF NIK WITH COMPOUND 4-{3-[2-AMINO-5-(2- METHOXYETHOXY)PYRIMIDIN-4-YL]-1H-INDOL-5-YL}-2-METHYLBUT-3-YN-2-OL (13V) | NIK, NUCLEAR FACTOR (NF)-KB, P100 PROCESSING, 2-AMINOPYRIMIDINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4idv:B (ALA438) to (GLY659) CRYSTAL STRUCTURE OF NIK WITH COMPOUND 4-{3-[2-AMINO-5-(2- METHOXYETHOXY)PYRIMIDIN-4-YL]-1H-INDOL-5-YL}-2-METHYLBUT-3-YN-2-OL (13V) | NIK, NUCLEAR FACTOR (NF)-KB, P100 PROCESSING, 2-AMINOPYRIMIDINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4idv:D (ALA438) to (GLY659) CRYSTAL STRUCTURE OF NIK WITH COMPOUND 4-{3-[2-AMINO-5-(2- METHOXYETHOXY)PYRIMIDIN-4-YL]-1H-INDOL-5-YL}-2-METHYLBUT-3-YN-2-OL (13V) | NIK, NUCLEAR FACTOR (NF)-KB, P100 PROCESSING, 2-AMINOPYRIMIDINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3fxw:A (SER78) to (HIS301) HIGH RESOLUTION CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE- ACTIVATED PROTEIN KINASE 3/INHIBITOR 2 COMPLEX | KINASE DOMAIN FOLD, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2cci:C (PRO45) to (GLN287) CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6 | COMPLEX (TRANSFERASE/CELL DIVISION), PROTEIN KINASES, CELL CYCLE, RECRUITMENT, SUBSTRATE RECOGNITION, ATP-BINDING, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHORYLATION, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE, CYCLIN, DNA REPLICATION, NUCLEAR PROTEIN, COMPLEX
1p5e:A (PRO45) to (GLN287) THE STRUCURE OF PHOSPHO-CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (TBS) | KINASE INHIBITOR, CDK2, TBS, CELL CYCLE
1p5e:C (PRO45) to (GLN287) THE STRUCURE OF PHOSPHO-CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (TBS) | KINASE INHIBITOR, CDK2, TBS, CELL CYCLE
2clq:A (GLN720) to (LYS939) STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5 | TRANSFERASE, METAL-BINDING, APOPTOSIS
2clq:B (GLN720) to (LYS939) STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5 | TRANSFERASE, METAL-BINDING, APOPTOSIS
2qok:A (THR660) to (ASN884) HUMAN EPHA3 KINASE AND JUXTAMEMBRANE REGION, Y596F:Y602F:S768A TRIPLE MUTANT | RECEPTOR TYROSINE KINASE, JUXTAMEMBRANE SEGMENT, STRUCTURAL GENOMICS, MUTANT, STRUCTURAL GENOMICS CONSORTIUM, SGC, ATP- BINDING, NUCLEOTIDE-BINDING, PHOSPHORYLATION, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
1pkd:C (PRO45) to (GLN287) THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO- CDK2/CYCLIN A | PROTEIN KINASE-DRUG COMPLEX, TRANSFERASE/CELL CYCLE COMPLEX
4j53:A (LYS91) to (ASP302) CRYSTAL STRUCTURE OF PLK1 IN COMPLEX WITH TAK-960 | PROTEIN SERINE/THREONINE KINASE, MITOSIS, ONCOGENESIS, REGULATION OF CELL CYCLE, KINASE DOMAIN, ATP BINDING, NUCLEAR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4y72:A (PRO45) to (ASN288) HUMAN CDK1/CYCLINB1/CKS2 WITH INHIBITOR | CDK1, CYCLINB1, CKS2, INHIBITOR, TRANSFERASE
4j99:A (THR524) to (THR764) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE GAIN-OF-FUNCTION K659T MUTATION. | BILOBATE PROTEIN KINASE FOLD, RECEPTOR TYROSINE KINASE, ATP BINDING, TRANSFERASE
4j99:D (THR524) to (THR764) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE GAIN-OF-FUNCTION K659T MUTATION. | BILOBATE PROTEIN KINASE FOLD, RECEPTOR TYROSINE KINASE, ATP BINDING, TRANSFERASE
4y85:A (LYS175) to (HIS385) CRYSTAL STRUCTURE OF COT KINASE DOMAIN IN COMPLEX WITH 5-(5-(1H-INDOL- 3-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-1,3,4-OXADIAZOL-2-AMINE | COT, TPL-2, MAP3K8, KINASE, INHIBITOR, COMPLEX, TRANSFERASE
4y85:B (LYS175) to (HIS385) CRYSTAL STRUCTURE OF COT KINASE DOMAIN IN COMPLEX WITH 5-(5-(1H-INDOL- 3-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-1,3,4-OXADIAZOL-2-AMINE | COT, TPL-2, MAP3K8, KINASE, INHIBITOR, COMPLEX, TRANSFERASE
4y85:C (LYS175) to (HIS385) CRYSTAL STRUCTURE OF COT KINASE DOMAIN IN COMPLEX WITH 5-(5-(1H-INDOL- 3-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-1,3,4-OXADIAZOL-2-AMINE | COT, TPL-2, MAP3K8, KINASE, INHIBITOR, COMPLEX, TRANSFERASE
1q41:B (ASN95) to (LEU320) GSK-3 BETA COMPLEXED WITH INDIRUBIN-3'-MONOXIME | KINASE, INSULIN PATHWAY, INDIRUBIN-3'-MONOXIME, TRANSFERASE
4jbq:A (VAL174) to (HIS380) NOVEL AURORA KINASE INHIBITORS REVEAL MECHANISMS OF HURP IN NUCLEATION OF CENTROSOMAL AND KINETOCHORE MICROTUBULES | AURORA KINASE INHIBITORS, HURP, MITOTIC SPINDLE, TRANSFERASE
3gu4:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DAPKQ23V-AMPPNP | GLYCINE-RICH LOOP MUTANT, KINASE-AMPPNP COMPLEX, ALTERNATIVE SPLICING, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN- BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3gu5:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPKQ23V-AMPPNP-MG2+ | GLYCINE-RICH LOOP MUTANT, KINASE-AMPPNP-MG2+ COMPLEX, ALTERNATIVE SPLICING, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3gu6:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DAPKQ23V-ADP | GLYCINE-RICH LOOP MUTANT, KINASE-ADP COMPLEX, ALTERNATIVE SPLICING, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN- BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3gu7:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DAPKQ23V-ADP-MG2+ | GLYCINE-RICH LOOP MUTANT, KINASE-ADP-MG2+ COMPLEX, ALTERNATIVE SPLICING, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3gub:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPKL93G COMPLEXED WITH N6-(2- PHENYLETHYL)ADENOSINE | GATEKEEPER MUTANT, KINASE-ADP COMPLEX, ALTERNATIVE SPLICING, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3tnw:C (PRO45) to (GLN287) STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH CAN508 | CYCLIN DEPENDENT KINASE, KINASE CYCLIN, PHOSPHOTRANSFERASE, CYCLIN A, PHOSPHORYLATION AT CDK2 THREONINE 160, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yc3:A (PRO45) to (ASN288) CDK1/CYCLINB1/CKS2 APO | CDK1, CYCLIN B1, CKS2, CELL CYCLE
2rku:A (PRO92) to (ASP302) STRUCTURE OF PLK1 IN COMPLEX WITH BI2536 | STRUCTURE OF PLK1, SELECTIVITY RESIDUES, KINASE, POLO-LIKE KINASE, STRUCTURE BASED DRUG DESIGN, ATP-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1qmz:A (PRO45) to (GLN287) PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX | CELL CYCLE, COMPLEX (PROTEIN KINASE/CYCLIN), CYCLIN, CDK, PHOSPHORYLATION, SUBSTRATE COMPLEX
1qmz:C (PRO45) to (GLN287) PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX | CELL CYCLE, COMPLEX (PROTEIN KINASE/CYCLIN), CYCLIN, CDK, PHOSPHORYLATION, SUBSTRATE COMPLEX
2uue:A (PRO45) to (HIS283) REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS | POLYMORPHISM, CYCLIN GROOVE, CELL DIVISION, CDK2, KINASE, CYCLIN, ACTIVE, MITOSIS, INHIBITION, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, NONPEPTIDE, TRANSFERASE, ATP-BINDING
2uue:C (PRO45) to (GLN287) REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS | POLYMORPHISM, CYCLIN GROOVE, CELL DIVISION, CDK2, KINASE, CYCLIN, ACTIVE, MITOSIS, INHIBITION, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, NONPEPTIDE, TRANSFERASE, ATP-BINDING
3ha6:A (VAL174) to (ASN386) CRYSTAL STRUCTURE OF AURORA A IN COMPLEX WITH TPX2 AND COMPOUND 10 | AURORA A, SERINE/THREONINE-PROTEIN KINASE, COFACTOR, TPX2, INHIBITOR, PHOSPHORYLATION, ATP-BINDING, CELL CYCLE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, NUCLEUS, KINASE
1f5q:A (SER46) to (GLN287) CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2 | HERPESVIRAL CYCLIN, CYCLIN DEPENDENT KINASE. PROTEIN/PROTEIN COMPLEX, TRANSFERASE
1f5q:C (SER46) to (GLN287) CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2 | HERPESVIRAL CYCLIN, CYCLIN DEPENDENT KINASE. PROTEIN/PROTEIN COMPLEX, TRANSFERASE
2uw6:A (ILE85) to (HIS294) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (S)-2-(4- CHLORO-PHENYL)-2-(4-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE | TRANSFERASE/INHIBITOR, CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION, TRANSFERASE/INHIBITOR COMPLEX
2uzd:A (PRO45) to (GLN287) CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR | TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
2uze:A (PRO45) to (GLN287) CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR | TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
2uze:C (PRO45) to (GLN287) CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR | TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
2uzl:A (PRO45) to (HIS283) CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR | TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
2uzt:A (ILE85) to (HIS294) PKA STRUCTURES OF AKT, INDAZOLE-PYRIDINE INHIBITORS | CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, PROTEIN KINASE A, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP- BINDING, AKT INHIBITORS, NUCLEAR PROTEIN
2v22:C (PRO45) to (GLN287) REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS | POLYMORPHISM, CYCLIN GROOVE, CELL DIVISION, CDK2, KINASE, CYCLIN, ACTIVE, MITOSIS, INHIBITION, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, NONPEPTIDE, TRANSFERASE, ATP-BINDING
1fin:A (PRO45) to (GLN287) CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX | COMPLEX (TRANSFERASE/CYCLIN), CYCLIN, CDK, PHOSPHORYLATION
1fot:A (VAL129) to (HIS338) STRUCTURE OF THE UNLIGANDED CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM SACCHAROMYCES CEREVISIAE | CAMP-DEPENDENT PROTEIN KINASE, OPEN CONFORMATION, PROTEIN KINASE, TRANSFERASE
1rek:A (GLN84) to (HIS294) CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 8 | PROTEIN KINASE, NATURAL PRODUCT INHIBITOR, LIGAND BINDING, SPECIFITY DETERMINANTS, CONFORMATIONAL MALLEABILITY, TRANSFERASE
3uiu:A (LYS304) to (TRP539) CRYSTAL STRUCTURE OF APO-PKR KINASE DOMAIN | KINASE DOMAIN, TRANSFERASE
3uiu:B (LYS304) to (TRP539) CRYSTAL STRUCTURE OF APO-PKR KINASE DOMAIN | KINASE DOMAIN, TRANSFERASE
4yu2:A (LYS194) to (LYS393) CRYSTAL STRUCTURE OF DYRK1A WITH HARMINE-DERIVATIZED ANNH-75 INHIBITOR | TRANSFERASE, DYRK1A, DOWN SYNDROME, INHIBITOR, HARMINE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
4yu2:B (LYS194) to (LYS393) CRYSTAL STRUCTURE OF DYRK1A WITH HARMINE-DERIVATIZED ANNH-75 INHIBITOR | TRANSFERASE, DYRK1A, DOWN SYNDROME, INHIBITOR, HARMINE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
1fvv:A (PRO45) to (GLN287) THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR | CYCLIN-DEPENDENT KINASE, CYCLIN A, TRANSFERASE, CELL CYCLE
2vgo:A (VAL134) to (HIS340) CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH REVERSINE INHIBITOR | NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, TRANSFERASE, COILED COIL, CELL DIVISION, KINASE, CANCER, INCENP, NUCLEUS, MITOSIS, AURORA B, METAL-BINDING, AMINOTHIAZOLE, PHOSPHORYLATION, MAGNESIUM, CELL CYCLE, CENTROMERE, MICROTUBULE
2vrx:A (VAL134) to (HIS340) STRUCTURE OF AURORA B KINASE IN COMPLEX WITH ZM447439 | SERINE/THREONINE-PROTEIN KINASE, KINASE, NUCLEUS, MITOSIS, MAGNESIUM, CELL CYCLE/TRANSFERASE, CENTROMERE, MICROTUBULE, ATP-BINDING, TRANSFERASE, ANTI-CANCER DRUG TARGET, PHOSPHOPROTEIN, PROTEIN KINASE, NUCLEOTIDE-BINDING, COILED COIL, CELL DIVISION, METAL-BINDING
2g9x:C (PRO45) to (GLN287) STRUCTURE OF THR 160 PHOSPHORYLATED CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR NU6271 | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, ATP-BINDING, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-CELL CYCLE COMPLEX
4zjj:B (GLU310) to (LEU502) PAK1 IN COMPLEX WITH (S)-N-(TERT-BUTYL)-3-((2-CHLORO-5-ETHYL-8-FLUORO- DIBENZODIAZEPIN-11-YL)AMINO)PYRROLIDINE-1-CARBOXAMIDE | PAK1, INHIBITOR, KINASE, ALLOSTERIC, TRANSFERASE
1h1p:A (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU2058 | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1h1q:C (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6094 | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1h24:C (PRO45) to (GLN287) CDK2/CYCLIN A IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F | TRANSFERASE, CELL CYCLE, PROTEIN KINASE, CYCLIN, CDK2, RECRUITMENT, PEPTIDE SPECIFICITY, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1h26:C (PRO45) to (GLN287) CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P53 | CELL CYCLE, PROTEIN KINASE, CYCLIN, CDK2, RECRUITMENT, PEPTIDE SPECIFICITY
1h27:C (PRO45) to (GLN287) CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P27 | CELL CYCLE, PROTEIN KINASE, CYCLIN, CDK2, RECRUITMENT, PEPTIDE SPECIFICITY, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, CELL DIVISION, MITOSIS, PHOSPHORYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3idb:A (ILE85) to (HIS294) CRYSTAL STRUCTURE OF (108-268)RIIB:C HOLOENZYME OF CAMP- DEPENDENT PROTEIN KINASE | PKA, CAMP, SPR, AFFINITY, KINASE, LINKER, CRYSTAL STRUCTURE, RII HOLOENZYME, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ACETYLATION, CAMP-BINDING
1h4l:A (PRO45) to (SER287) STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX | KINASE/KINASE ACTIVATOR, COMPLEX(CYCLINS/CDK), CYCLINS, CYCLIN-DEPENDENT KINASES, CDK5, P35, P25, TRANSFERASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, PHOSPHORYLATION
2gsf:A (THR660) to (ASN884) THE HUMAN EPHA3 RECEPTOR TYROSINE KINASE AND JUXTAMEMBRANE REGION | ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, RECEPTOR, SIGNAL, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
4ztq:A (VAL174) to (HIS380) HUMAN AURORA A CATALYTIC DOMAIN BOUND TO FK932 | AURORA, KINASE, INHIBITOR, TRANSFERASE
3ion:A (LYS123) to (HIS339) PDK1 IN COMPLEX WITH COMPOUND 8H | PDK-1, INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2wev:C (PRO45) to (GLN287) TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN | CDK2, KINASE, CYCLIN, ACTIVE, NUCLEUS, MITOSIS, SERINE/THREONINE-PROTEIN KINASE, CYTOPLASM, INHIBITION, CELL CYCLE, ATP-BINDING, CELL DIVISION, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE, POLYMORPHISM, BETA-PEPTIDE, CYCLIN GROOVE
2wfy:C (PRO45) to (GLN287) TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN | CDK2, KINASE, CYCLIN, ACTIVE, NUCLEUS, MITOSIS, SERINE/THREONINE-PROTEIN KINASE, CYTOPLASM, INHIBITION, CELL CYCLE, ATP-BINDING, CELL DIVISION, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE, POLYMORPHISM, BETA-PEPTIDE, CYCLIN GROOVE
2whb:C (PRO45) to (GLN287) TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN | CDK2, KINASE, CYCLIN, ACTIVE, NUCLEUS, MITOSIS, SERINE/THREONINE-PROTEIN KINASE, CYTOPLASM, INHIBITION, CELL CYCLE, ATP-BINDING, CELL DIVISION, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE, POLYMORPHISM, BETA-PEPTIDE, CYCLIN GROOVE
2wmb:C (PRO45) to (GLN287) STRUCTURAL AND THERMODYNAMIC CONSEQUENCES OF CYCLIZATION OF PEPTIDE LIGANDS FOR THE RECRUITMENT SITE OF CYCLIN A | CELL CYCLE, CELL DIVISION, ANTI-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, TRANSCRIPTION REGULATION, CHROMATIN REGULATOR, RECRUITMENT, TRANSCRIPTION, NUCLEUS, MITOSIS, ATP-BINDING, TRANSFERASE
3vw6:A (PRO721) to (LYS939) CRYSTAL STRUCTURE OF HUMAN APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) WITH IMIDAZOPYRIDINE INHIBITOR | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1ig1:A (ARG58) to (HIS272) 1.8A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MN. | TRANSFERASE
2i40:A (PRO45) to (GLN287) CDK2/CYCLIN A COMPLEXED WITH A THIOPHENE CARBOXAMIDE INHIBITOR | CDK2, CYCLIN, KINASE, TRANSFERASE-CELL CYCLE COMPLEX
2i40:C (PRO45) to (GLN287) CDK2/CYCLIN A COMPLEXED WITH A THIOPHENE CARBOXAMIDE INHIBITOR | CDK2, CYCLIN, KINASE, TRANSFERASE-CELL CYCLE COMPLEX
2wxv:A (PRO45) to (HIS283) STRUCTURE OF CDK2-CYCLIN A WITH A PYRAZOLO(4,3-H) QUINAZOLINE-3-CARBOXAMIDE INHIBITOR | NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, TRANSFERASE, KINASE, CYCLIN
2wxv:C (PRO45) to (GLN287) STRUCTURE OF CDK2-CYCLIN A WITH A PYRAZOLO(4,3-H) QUINAZOLINE-3-CARBOXAMIDE INHIBITOR | NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, TRANSFERASE, KINASE, CYCLIN
1urc:A (PRO45) to (HIS283) CYCLIN A BINDING GROOVE INHIBITOR ACE-ARG-LYS-LEU-PHE-GLY | TRANSFERASE-INHIBITOR COMPLEX, INHIBITOR, LIGAND EXCHANGE, DRUG DESIGN, PEPTIDOMIMETICS
1v0o:A (SER45) to (HIS281) STRUCTURE OF P. FALCIPARUM PFPK5-INDIRUBIN-5-SULPHONATE LIGAND COMPLEX | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, CDK
2itn:A (PRO753) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN G719S MUTATION IN COMPLEX WITH AMP-PNP | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, ANP, EGFR, G719S, KINASE, AMP-PNP, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2ito:A (SER752) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN G719S MUTATION IN COMPLEX WITH IRESSA | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, IRESSA, EGFR, G719S, ZD1839, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2itt:A (PRO753) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN L858R MUTATION IN COMPLEX WITH AEE788 | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, AEE788, EGFR, L858R, KINASE, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2itu:A (SER752) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN L858R MUTATION IN COMPLEX WITH AFN941 | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, AFN941, EGFR, L858R, STAUROSPORINE, MEMBRANE TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2itv:A (PRO753) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN L858R MUTATION IN COMPLEX WITH AMP-PNP | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, ANP, EGFR, L858R, KINASE, AMP-PNP, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2ity:A (SER752) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH IRESSA | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, IRESSA, EGFR, ZD1839, MEMBRANE TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2itz:A (PRO753) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN L858R MUTATION IN COMPLEX WITH IRESSA | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, IRESSA, EGFR, L858R, GEFITINIB, ZD1839, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2ivs:B (PRO766) to (ARG1012) CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED RET TYROSINE KINASE DOMAIN | NUCLEOTIDE-BINDING, HIRSCHSPRUNG DISEASE, PHOSPHORYLATION, DISEASE MUTATION, PHOSPHOTRANSFERASE, TYROSINE-PROTEIN KINASE, CHROMOSOMAL TRANSLOCATION, POLYMORPHISM, GDNF RECEPTOR, TRANSMEMBRANE, PROTO-ONCOGENE, TYROSINE KINASE, RET, KINASE, MEMBRANE, ATP-BINDING, TRANSFERASE
2iw6:C (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR | PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE COMPLEX, KINASE, MITOSIS, CELL CYCLE, TRANSFERASE, ATP-BINDING
2iw8:A (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V- H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR | PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE COMPLEX, KINASE, MITOSIS, CELL CYCLE, TRANSFERASE
2j0l:A (LEU469) to (GLN686) CRYSTAL STRUCTURE OF A THE ACTIVE CONFORMATION OF THE KINASE DOMAIN OF FOCAL ADHESION KINASE WITH A PHOSPHORYLATED ACTIVATION LOOP. | FOCAL ADHESION, CELL MIGRATION, PHOSPHORYLATION, FERM, KINASE, TRANSFERASE, ATP-BINDING, INTEGRIN SIGNALING, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE
1jkl:A (SER57) to (HIS272) 1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE | TRANSFERASE
5aut:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH ANS. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERIN/THREONINE PROTEIN KINASE, COMPLEX
5auv:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH APIGENIN. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5auw:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH QUERCETIN. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5aux:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH KAEMPFEROL. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5auy:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH MORIN. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5auz:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH GENISTEIN. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5av1:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 IN THE PRESENCE OF BROMIDE IONS. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5av3:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1-KAEMPFEROL COMPLEX IN THE PRESENCE OF IODIDE IONS. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5av4:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1-GENISTEIN COMPLEX IN THE PRESENCE OF BROMIDE IONS. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
2j5f:A (PRO753) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AN IRREVERSIBLE INHIBITOR 34-JAB | CELL CYCLE, ATP-BINDING, TRANSFERASE, POLYMORPHISM, IRREVERSIBLE INHIBITOR, TYROSINE-PROTEIN KINASE, EGFR, KINASE, 34-JAB, MEMBRANE, RECEPTOR, WILD-TYPE, EPIDERMAL GROWTH FACTOR, ANTI-ONCOGENE, TRANSMEMBRANE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, UBL CONJUGATION, PHOSPHORYLATION, DISEASE MUTATION, GLYCOPROTEIN
2j6m:A (SER752) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AEE788 | CELL CYCLE, ATP-BINDING, TRANSFERASE, POLYMORPHISM, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR, UBL CONJUGATION, PHOSPHORYLATION, DISEASE MUTATION, GLYCOPROTEIN, ANTI- ONCOGENE, TRANSMEMBRANE, EGFR, KINASE, AEE788, MEMBRANE, RECEPTOR, WILD-TYPE
1jst:A (PRO45) to (GLN287) PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A | COMPLEX (PROTEIN KINASE-CYCLIN), CYCLIN, CDK, PHOSPHORYLATION, COMPLEX (PROTEIN KINASE-CYCLIN) COMPLEX
1jst:C (PRO45) to (GLN287) PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A | COMPLEX (PROTEIN KINASE-CYCLIN), CYCLIN, CDK, PHOSPHORYLATION, COMPLEX (PROTEIN KINASE-CYCLIN) COMPLEX
1vyw:A (PRO45) to (HIS283) STRUCTURE OF CDK2/CYCLIN A WITH PNU-292137 | TRANSFERASE/COMPLEX, PROTEIN KINASE/COMPLEX, PROTEIN KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, CELL DIVISION, CYCLIN
1vyw:C (PRO45) to (GLN287) STRUCTURE OF CDK2/CYCLIN A WITH PNU-292137 | TRANSFERASE/COMPLEX, PROTEIN KINASE/COMPLEX, PROTEIN KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, CELL DIVISION, CYCLIN
2jbp:C (PRO99) to (LYS307) PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-2, CO-CRYSTALLIZATION) | SER-THR KINASE, MAPKAP KINASE 2, PHOSPHORYLATION, SMALL MOLECULE INHIBITOR, MK2, KINASE, ATP SITE, TRANSFERASE, ATP- BINDING, SERINE/THREONINE-PROTEIN KINASE, CO- CRYSTALLIZATION, NUCLEOTIDE-BINDING
2jbp:D (PRO99) to (HIS322) PROTEIN KINASE MK2 IN COMPLEX WITH AN INHIBITOR (CRYSTAL FORM-2, CO-CRYSTALLIZATION) | SER-THR KINASE, MAPKAP KINASE 2, PHOSPHORYLATION, SMALL MOLECULE INHIBITOR, MK2, KINASE, ATP SITE, TRANSFERASE, ATP- BINDING, SERINE/THREONINE-PROTEIN KINASE, CO- CRYSTALLIZATION, NUCLEOTIDE-BINDING
3zbf:A (ASP1988) to (SER2229) STRUCTURE OF HUMAN ROS1 KINASE DOMAIN IN COMPLEX WITH CRIZOTINIB | TRANSFERASE, TYROSINE KINASE
3zfx:A (SER658) to (ASN884) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:B (SER658) to (ILE882) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:D (SER658) to (ILE882) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:E (SER658) to (ILE882) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:F (SER658) to (ASN884) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:G (SER667) to (ASN884) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:H (SER658) to (ASN884) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
3zfx:I (SER658) to (ASN884) CRYSTAL STRUCTURE OF EPHB1 | TRANSFERASE
1w98:A (PRO45) to (HIS283) THE STRUCTURAL BASIS OF CDK2 ACTIVATION BY CYCLIN E | CELL CYCLE, TRANSFERASE
5bvf:A (HIS59) to (SER264) TETRAHYDROPYRROLO-DIAZEPENONES AS INHIBITORS OF ERK2 KINASE | INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2ya9:B (ARG58) to (HIS272) CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 | TRANSFERASE, APOPTOSIS
1wzy:A (GLN62) to (SER266) CRYSTAL STRUCTURE OF HUMAN ERK2 COMPLEXED WITH A PYRAZOLOPYRIDAZINE DERIVATIVE | ERK2, INHIBITOR, KINASE, TRANSFERASE
4nst:C (PRO768) to (SER1017) CRYSTAL STRUCTURE OF HUMAN CDK12/CYCLIN K IN COMPLEX WITH ADP-ALUMINUM FLUORIDE | TRANSCRIPTION, RNA POLYMERASE II, PHOSPHORYLATION, TRANSFERASE- TRANSCRIPTION COMPLEX
3zxt:B (SER57) to (HIS272) DIMERIC STRUCTURE OF DAPK-1 CATALYTIC DOMAIN IN COMPLEX WITH AMPPCP-MG | APOPTOSIS, TRANSFERASE, ATP BINDING
4o0r:A (LYS308) to (HIS518) BACK POCKET FLEXIBILITY PROVIDES GROUP-II PAK SELECTIVITY FOR TYPE 1 KINASE INHIBITORS | PAK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cas:A (PRO753) to (ARG973) EGFR KINASE DOMAIN MUTANT "TMLR" WITH COMPOUND 41A | PROTEIN KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cau:A (LYS754) to (ARG973) EGFR KINASE DOMAIN MUTANT "TMLR" WITH COMPOUND 41B | PROTEIN KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4o2p:B (SER303) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH A SUBSTITUTED PYRAZOLOPYRIMIDINE | PYRAZOLO-PYRIMIDINE LIGAND, TYPE I, DFG-IN, TYROSINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1xh8:A (GLN84) to (HIS294) CRYSTAL STRUCTURES OF PROTEIN KINASE B SELECTIVE INHIBITORS IN COMPLEX WITH PROTEIN KINASE A AND MUTANTS | PKA, KINASE-INHIBITOR-COMPLEX, SERINE/THREONINE-PROTEIN KINASE, BALANOL DERIVATIVE, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
1xh9:A (ILE85) to (ALA298) CRYSTAL STRUCTURES OF PROTEIN KINASE B SELECTIVE INHIBITORS IN COMPLEX WITH PROTEIN KINASE A AND MUTANTS | PKA, KINASE-INHIBITOR-COMPLEX, SERINE/THREONINE-PROTEIN KINASE, BALANOL DERIVATIVE, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
1xha:A (GLU84) to (ALA298) CRYSTAL STRUCTURES OF PROTEIN KINASE B SELECTIVE INHIBITORS IN COMPLEX WITH PROTEIN KINASE A AND MUTANTS | PKA, KINASE-INHIBITOR-COMPLEX, SERINE/THREONINE-PROTEIN KINASE, BALANOL DERIVATIVE, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
4oau:C (SER398) to (HIS568) COMPLETE HUMAN RNASE L IN COMPLEX WITH BIOLOGICAL ACTIVATORS. | RNASE L, RNASEL, 2-5A, 2',5'-OLIGOADENYLATE, INTERFERON, KEN, PSEUDOKINASE, KINASE, INFLAMMATION, IRE1, RIDD, REGULATED RNA DECAY, SPLICING CLEAVAGE, HPC1, HEREDITARY PROSTATE CANCER 1, RNASE L KINASE-HOMOLOGY AND KEN DOMAIN-CONTAINING, INNATE IMMUNITY, INTERFERON RESPONSE, ANTIVIRAL RESPONSE, 2-5A (2',5'-LINKED OLIGOADENYLATE)AND RNA, HYDROLASE-RNA COMPLEX
5ci7:A (LEU53) to (ASP279) STRUCTURE OF ULK1 BOUND TO A SELECTIVE INHIBITOR | INHIBITOR, KINASE, AUTOPHAGY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2z8c:A (SER1037) to (LEU1262) PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH (4-{[5-CARBAMOYL-4-(3-METHYLANILINO)PYRIMIDIN-2- YL]AMINO}PHENYL)ACETIC ACID | TRANSFERASE, ALTERNATIVE SPLICING, ATP-BINDING, CARBOHYDRATE METABOLISM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DIABETES MELLITUS, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSDUCER
4a4o:A (PRO92) to (ASP302) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2- (2-AMINO-PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN- 4-ONE INHIBITOR | TRANSFERASE
3kb7:A (PRO92) to (THR306) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A PYRAZOLOQUINAZOLINE INHIBITOR | PROTEIN KINASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2zm3:B (MET1054) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND ISOQUINOLINEDIONE INHIBITOR | IGFR, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP- BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
2zm3:D (MET1054) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND ISOQUINOLINEDIONE INHIBITOR | IGFR, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP- BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3kkv:A (ILE85) to (ALA298) STRUCTURE OF PKA WITH A PROTEIN KINASE B-SELECTIVE INHIBITOR. | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ae6:A (ILE85) to (HIS294) STRUCTURE AND FUNCTION OF THE HUMAN SPERM-SPECIFIC ISOFORM OF PROTEIN KINASE A (PKA) CATALYTIC SUBUNIT CALPHA 2 | TRANSFERASE
4pf4:A (SER57) to (GLN271) 1.1A X-RAY STRUCTURE OF THE APO CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE 1, AA 1-277 | TRANSFERASE
5dh3:A (LEU64) to (HIS275) CRYSTAL STRUCTURE OF MST2 IN COMPLEX WITH XMU-MP-1 | MST2, MST1, HIPPO PATHWAY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dn3:A (GLU175) to (ASN386) AURORA A IN COMPLEX WITH ATP AND AA35. | AURORA A KINASE, MITOTIC KINASE, PPI, TRANSFERASE
3l9l:A (GLN84) to (ALA298) CRYSTAL STRUCTURE OF PKA WITH COMPOUND 36 | PKB, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3l9l:B (GLN84) to (ALA298) CRYSTAL STRUCTURE OF PKA WITH COMPOUND 36 | PKB, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3l9m:A (GLN84) to (ALA298) CRYSTAL STRUCTURE OF PKAB3 (PKA TRIPLE MUTANT V123A, L173M, Q181K) WITH COMPOUND 18 | PKB, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3l9m:B (GLN84) to (HIS294) CRYSTAL STRUCTURE OF PKAB3 (PKA TRIPLE MUTANT V123A, L173M, Q181K) WITH COMPOUND 18 | PKB, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dpv:A (VAL174) to (HIS380) AURORA A KINASE IN COMPLEX WITH AA35 AND JNJ-7706621 IN SPACE GROUP P6122 | AURORA A KINASE, MITOTIC KINASE, PPI, TRANSFERASE
5dyk:A (GLN582) to (HIS795) CRYSTAL STRUCTURE OF PF3D7_1436600 | TRANSFERASE, KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
5dzc:A (GLN575) to (GLY792) CRYSTAL STRUCTURE OF PVX_084705 IN COMPLEX WITH AMP-PNP | STRUCTURAL GENOMICS CONSORTIUM (SGC), KINASE, TRANSFERASE
2a19:B (ASN302) to (LYS540) PKR KINASE DOMAIN- EIF2ALPHA- AMP-PNP COMPLEX. | TRANSFERASE, KINASE, PROTEIN BIOSYNTHESIS, PROTEIN SYNTHESIS- TRANSFERASE COMPLEX
4b6l:A (PRO101) to (HIS311) DISCOVERY OF ORAL POLO-LIKE KINASE (PLK) INHIBITORS WITH ENHANCED SELECTIVITY PROFILE USING RESIDUE TARGETED DRUG DESIGN | TRANSFERASE, KINASE INHIBITORS, WATER-MEDIATED H-BOND
3b2t:A (THR524) to (THR765) STRUCTURE OF PHOSPHOTRANSFERASE | PHOSPHOTRANSFERASE, CELL SIGNALING, ALTERNATIVE SPLICING, ATP-BINDING, DISEASE MUTATION, ECTODERMAL DYSPLASIA, GLYCOPROTEIN, HEPARIN-BINDING, IMMUNOGLOBULIN DOMAIN, KINASE, LACRIMO-AURICULO-DENTO-DIGITAL SYNDROME, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, RECEPTOR, SECRETED, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3b2t:B (THR524) to (THR764) STRUCTURE OF PHOSPHOTRANSFERASE | PHOSPHOTRANSFERASE, CELL SIGNALING, ALTERNATIVE SPLICING, ATP-BINDING, DISEASE MUTATION, ECTODERMAL DYSPLASIA, GLYCOPROTEIN, HEPARIN-BINDING, IMMUNOGLOBULIN DOMAIN, KINASE, LACRIMO-AURICULO-DENTO-DIGITAL SYNDROME, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, RECEPTOR, SECRETED, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
4b8m:A (VAL134) to (HIS340) AURORA B KINASE IN COMPLEX WITH VX-680 | CELL CYCLE, CANCER
2acx:A (GLU228) to (HIS445) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 6 BOUND TO AMPPNP | KINASE, G PROTEIN, GRK, G PROTEIN COUPLED RECEPTOR KINASE, GRK6, TRANSFERASE
2acx:B (GLU228) to (HIS445) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 6 BOUND TO AMPPNP | KINASE, G PROTEIN, GRK, G PROTEIN COUPLED RECEPTOR KINASE, GRK6, TRANSFERASE
4bcn:C (PRO45) to (GLN287) STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4- HETEROARYL-PYRIMIDINE INHIBITOR | TRANSFERASE-CELL CYCLE COMPLEX, CDK-CYCLIN COMPLEX, CYCLIN-INHIBITOR, STRUCTURE-BASED DRUG DESIGN
4bcp:C (PRO45) to (GLN287) STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4- HETEROARYL-PYRIMIDINE INHIBITOR | TRANSFERASE-CELL CYCLE COMPLEX, CDK-CYCLIN COMPLEX, CYCLIN-INHIBITOR, STRUCTURE-BASED DRUG DESIGN
4qp2:B (GLN62) to (HIS310) CRYSTAL STRUCTURE OF ERKS IN COMPLEX WITH 5-CHLOROBENZO[D]OXAZOL-2- AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4bf2:A (GLU724) to (LYS939) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
4bf2:B (GLU724) to (ASP935) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
4bhn:A (HIS723) to (ASP935) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE, STRUCTURE BASED DESIGN
4bhn:B (GLN720) to (ASP935) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE, STRUCTURE BASED DESIGN
4bic:A (GLN720) to (LYS939) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
4bic:B (GLN720) to (LYS939) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
4bie:A (GLU724) to (LYS939) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE, STRUCTURE BASED DESGIN
3bht:A (PRO45) to (GLN287) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR MERIOLIN 3 | SER/THR PROTEIN KINASE, TRANSFERASE, PHOSPHORYLATION, CELL CYCLE, ATP-BINDING, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, CYCLIN
3bht:C (PRO45) to (GLN287) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR MERIOLIN 3 | SER/THR PROTEIN KINASE, TRANSFERASE, PHOSPHORYLATION, CELL CYCLE, ATP-BINDING, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, CYCLIN
5f0a:A (GLN575) to (GLY792) CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND 1-TERT-BUTYL-3-(3- CHLOROPHENOXY)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE INHIBITOR | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3mvj:E (ILE85) to (ALA298) HUMAN CYCLIC AMP-DEPENDENT PROTEIN KINASE PKA INHIBITOR COMPLEX | KINASE INHIBITOR, TRANSFERASE
4qyy:A (GLN60) to (LEU265) DISCOVERY OF NOVEL, DUAL MECHANISM ERK INHIBITORS BY AFFINITY SELECTION SCREENING OF AN INACTIVE KINASE STATE | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3my5:A (PRO45) to (GLN287) CDK2/CYCLINA IN COMPLEX WITH DRB | CDK, CYCLIN, INHIBITOR, DRB, TRANSFERASE-PROTEIN BINDING-INHIBITOR COMPLEX
3my5:C (PRO45) to (GLN287) CDK2/CYCLINA IN COMPLEX WITH DRB | CDK, CYCLIN, INHIBITOR, DRB, TRANSFERASE-PROTEIN BINDING-INHIBITOR COMPLEX
5fee:A (PRO753) to (ARG973) EGFR KINASE DOMAIN T790M MUTANT IN COMPLEX WITH A COVALENT AMINOBENZIMIDAZOLE INHIBITOR. | KINASE, INHIBITOR, COVALENTLY BOUND, T790M, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5feq:A (SER752) to (ARG973) EGFR KINASE DOMAIN IN COMPLEX WITH A COVALENT AMINOBENZIMIDAZOLE | KINASE, INHIBITOR, COVALENTLY BOUND, T790M, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4r5s:A (SER752) to (ALA972) CRYSTAL STRUCTURE OF EGFR 696-1022 L858R IN COMPLEX WITH FIIN-3 | EGFR, L858R, KINASE, FIIN-3, TRANSFERASE
3c4w:A (GLY228) to (ILE455) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ATP AND MAGNESIUM CHLORIDE AT 2.7A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, PHOSPHOTHREONINE, AUTOPHOSPHORYLATION, AMPHIPATHIC, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4w:B (TYR229) to (ILE455) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ATP AND MAGNESIUM CHLORIDE AT 2.7A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, PHOSPHOTHREONINE, AUTOPHOSPHORYLATION, AMPHIPATHIC, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c51:B (GLY228) to (ILE455) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ADP AND MAGNESIUM CHLORIDE AT 3.55A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ADP, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4c2v:A (HIS136) to (HIS340) AURORA B KINASE IN COMPLEX WITH THE SPECIFIC INHIBITOR BARASERTIB | TRANSFERASE-CELL CYCLE COMPLEX, AZD1152
4c2w:A (GLU135) to (HIS340) CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH AMP-PNP | TRANSFERASE
4c33:A (ILE85) to (HIS294) PKA-S6K1 CHIMERA APO | TRANSFERASE-INHIBITOR COMPLEX
3cjg:A (HIS874) to (ALA1166) CRYSTAL STRUCTURE OF VEGFR2 IN COMPLEX WITH A 3,4,5-TRIMETHOXY ANILINE CONTAINING PYRIMIDINE | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2. VEGFR-2, KINASE INSERT DOMAIN RECEPTOR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, ANGIOGENESIS, ATP-BINDING, DEVELOPMENTAL PROTEIN, DIFFERENTIATION, GLYCOPROTEIN, HOST-VIRUS INTERACTION, IMMUNOGLOBULIN DOMAIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
4rj7:A (PRO753) to (PRO975) EGFR KINASE (T790M/L858R) WITH INHIBITOR COMPOUND 1 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3nuy:A (LYS123) to (HIS339) PHOSPHOINOSITIDE-DEPENDENT KINASE-1 (PDK1) WITH FRAGMENT17 | KINASE DOMAIN, TRANSFERASE
4cfh:A (VAL57) to (HIS265) STRUCTURE OF AN ACTIVE FORM OF MAMMALIAN AMPK | TRANSFERASE, TRANSFERASE PHOSPHORYLATION, ACTIVE FORM, NUCLEOTIDE- BINDING, STAUROSPORINE-BINDING, SERINE/THREONINE-PROTEIN KINASE
4cfv:A (PRO45) to (GLN287) STRUCTURE-BASED DESIGN OF C8-SUBSTITUTED O6- CYCLOHEXYLMETHOXYGUANINE CDK1 AND 2 INHIBITORS. | TRANSFERASE, CYCLIN DEPENDENT KINASES, STRUCTURE-BASED DRUG DESIGN, CONFORMATIONAL RESTRAINT, REVERSED BINDING MODE
4rz7:A (ASN578) to (GLY792) CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND PCI32765 | STRUCTURAL GENOMICS CONSORTIUM, SGC, KINASE, PCI32765, TRANSFERASE
3o7l:B (GLN84) to (HIS294) CRYSTAL STRUCTURE OF PHOSPHOLAMBAN (1-19):PKA C-SUBUNIT:AMP-PNP:MG2+ COMPLEX | PROTEIN KINASE A, PHOSPHOLAMBAN, ALLOSTERY, SUBSTRATE RECOGNITION, CONFORMATIONAL SELECTION, INTRINSICALLY DISORDERED PROTEINS, MEMBRANE PROTEINS, TRANSFERASE
3dbe:A (LYS77) to (THR292) CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 557 | POLO-LIKE KINASE 1, PLK1, CATALYTIC DOMAIN, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
4tpt:A (VAL377) to (GLY609) CRYSTAL STRUCTURE OF THE HUMAN LIMK2 KINASE DOMAIN IN COMPLEX WITH A NON-ATP COMPETITIVE INHIBITOR | LIMK2 KINASE, DFG INHIBITOR
3dfc:B (ARG58) to (HIS272) CRYSTAL STRUCTURE OF A GLYCINE-RICH LOOP MUTANT OF THE DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH AMPPNP | KINASE DOMAIN, GLYCINE-RICH LOOP MUTATION, AMPPNP, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3dgk:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF A GLYCINE-RICH LOOP MUTANT OF THE DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN | KINASE DOMAIN, GLYCINE-RICH LOOP MUTATION, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3dne:A (ILE85) to (ALA298) CAMP-DEPENDENT PROTEIN KINASE PKA CATALYTIC SUBUNIT WITH PKI-5-24 | ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, CAMP, PROTEIN KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3dog:C (PRO45) to (GLN287) STRUCTURE OF THR 160 PHOSPHORYLATED CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR N-&-N1 | SER/THR PROTEIN KINASE; TRANSFERASE; PHOSPHORYLATION; CELL CYCLE, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, CYCLIN, CYTOPLASM, NUCLEUS
3dqx:B (SER303) to (TYR519) CHICKEN C-SRC KINASE DOMAIN IN COMPLEX WITH ATPGS | SRC, KINASE, ACTIVE, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3orz:B (VAL124) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT ACTIVATOR 2A2 | C HELIX, SER/THR-KINASE, AGC KINASE, ALLOSTERY, TRANSFERASE, ALLOSTERIC ACTIVATOR, BISINDOLYLMALEIMIDE, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
5hcy:A (PRO753) to (ARG973) EGFR KINASE DOMAIN MUTANT "TMLR" WITH 3-CARBOXAMIDE AZAINDOLE COMPOUND 13 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hd4:A (GLN60) to (LEU265) DISSECTING THERAPEUTIC RESISTANCE TO ERK INHIBITION RAT WILD TYPE SCH772984 IN COMPLEX WITH (3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL) PHENYL]PIPERAZIN-1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hd7:A (GLN60) to (LEU265) DISSECTING THERAPEUTIC RESISTANCE TO ERK INHIBITION RAT MUTANT SCH772984 IN COMPLEX WITH (3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL) PHENYL]PIPERAZIN-1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4dfz:E (ILE85) to (HIS294) CRYSTAL STRUCTURE OF MYRISTOYLATED K7C CATALYTIC SUBUNIT OF CAMP- DEPENDENT PROTEIN KINASE IN COMPLEX WITH SP20 | PROTEIN KINASE, MYRISTOYLATED, PHOSPHOTRANSFERASE OF SER/THR, MG, PKI, PKA REGULATORY SUBUNITS, PHOSPHORYLATED ON S139, T197, S338, MYRISTOYLATED ON G1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hic:A (SER752) to (ARG973) EGFR KINASE DOMAIN MUTANT "TMLR" WITH A IMIDAZOPYRIDINYL- AMINOPYRIMIDINE INHIBITOR | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u5j:A (SER303) to (TYR519) C-SRC IN COMPLEX WITH RUXOLITINIB | C-SRC, RUXOLITINIB, KINASE, INHIBITOR
4u5j:B (GLU305) to (TYR519) C-SRC IN COMPLEX WITH RUXOLITINIB | C-SRC, RUXOLITINIB, KINASE, INHIBITOR
3p1a:A (LYS149) to (LEU356) STRUCTURE OF HUMAN MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE- SPECIFIC CDC2-INHIBITORY KINASE MYT1 (PKMYT1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, TYROSINE- AND THREONINE-SPECIFIC KINASE, MEMBRANE-ASSOCIATED PROTEIN KINASE, TRANSFERASE
4dn5:B (ALA438) to (GLY659) CRYSTAL STRUCTURE OF NF-KB-INDUCING KINASE (NIK) | NON-RD KINASE, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE, ATP BINDING
5hq0:A (PRO45) to (ASN288) TERNARY COMPLEX OF HUMAN PROTEINS CDK1, CYCLIN B AND CKS2, BOUND TO AN INHIBITOR | CDK1, CYCLIN B, CKS2, CELL-CYCLE, PROTEIN KINASE, INHIBITOR, TRANSFERASE
3e5a:A (GLU175) to (HIS380) CRYSTAL STRUCTURE OF AURORA A IN COMPLEX WITH VX-680 AND TPX2 | AURORA A, SERINE/THREONINE-PROTEIN KINASE, COFACTOR, TPX2, VX-680, INHIBITOR, PHOSPHORYLATION, ATP-BINDING, CELL CYCLE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, TRANSFERASE, NUCLEUS
4ueu:A (SER45) to (THR261) TYROSINE KINASE AS - A COMMON ANCESTOR OF SRC AND ABL | TRANSFERASE, ANCESTOR PROTEIN, AMPPCP, DFG-IN
5i9u:A (THR653) to (ALA877) CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE | TRANSFERASE, TYROSINE-PROTEIN KINASE, RECEPTOR, ATP-BINDING
5i9v:A (THR653) to (ALA877) CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH AGS | TRANSFERASE, TYROSINE-PROTEIN KINASE, RECEPTOR, ATP-BINDING
5if1:A (PRO45) to (HIS283) CRYSTAL STRUCTURE APO CDK2/CYCLIN A | ANTINEOPLASTIC AGENTS, CYCLIN-DEPENDENT KINASES, DOSE-RESPONSE RELATIONSHIP, DRUG, DRUG DISCOVERY, HELA CELLS, MOLECULAR STRUCTURE, NEOPLASMS, PROTEIN KINASE INHIBITORS, PYRIMIDINES, STRUCTURE- ACTIVITY RELATIONSHIP, STRUCTURE-KINETICS RELATIONSHIP, SULFOXIDES, BIOPHYSICAL ASSAYS, TUMOR, HUMANS, TRANSFERASE
5if1:C (PRO45) to (HIS283) CRYSTAL STRUCTURE APO CDK2/CYCLIN A | ANTINEOPLASTIC AGENTS, CYCLIN-DEPENDENT KINASES, DOSE-RESPONSE RELATIONSHIP, DRUG, DRUG DISCOVERY, HELA CELLS, MOLECULAR STRUCTURE, NEOPLASMS, PROTEIN KINASE INHIBITORS, PYRIMIDINES, STRUCTURE- ACTIVITY RELATIONSHIP, STRUCTURE-KINETICS RELATIONSHIP, SULFOXIDES, BIOPHYSICAL ASSAYS, TUMOR, HUMANS, TRANSFERASE
4utd:A (VAL174) to (ASN386) STRUCTURE OF DEPHOSPHORYLATED AURORA A (122-403) BOUND TO AMPPCP IN AN ACTIVE CONFORMATION | TRANSFERASE, ACTIVATION, CELL CYCLE, CANCER
3pvw:A (GLY232) to (SER450) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND A SELECTIVE KINASE INHIBITOR (CMPD103A) | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, INHIBITOR, MEMBRANE, TRANSFERASE-SIGNALING PROTEIN-INHIBITOR COMPLEX
4eoi:A (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 K89D, Q131E - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eoi:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 K89D, Q131E - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eoj:A (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, K89D - HUMAN CYCLIN A3 COMPLEX WITH ATP | PROTEIN KINASE, CELL CYCLE, COMPLEX, PHOSPHORYLATION, TRANSFERASE
4eok:A (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, K89D - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR NU6102 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eol:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, K89D - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eom:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, Q131E - HUMAN CYCLIN A3 COMPLEX WITH ATP | PROTEIN KINASE, CELL CYCLE, COMPLEX, PHOSPHORYLATION, TRANSFERASE
4eon:A (PRO45) to (HIS283) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, Q131E - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eon:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, Q131E - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eoo:A (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 Q131E - HUMAN CYCLIN A3 COMPLEX WITH ATP | PROTEIN KINASE, CELL CYCLE, COMPLEX, PHOSPHORYLATION, TRANSFERASE
4eoo:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 Q131E - HUMAN CYCLIN A3 COMPLEX WITH ATP | PROTEIN KINASE, CELL CYCLE, COMPLEX, PHOSPHORYLATION, TRANSFERASE
4eop:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 Q131E - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eoq:A (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 WT - HUMAN CYCLIN A3 COMPLEX WITH ATP | PROTEIN KINASE, CELL CYCLE, COMPLEX, PHOSPHORYLATION, TRANSFERASE
4eoq:C (PRO45) to (GLN287) THR 160 PHOSPHORYLATED CDK2 WT - HUMAN CYCLIN A3 COMPLEX WITH ATP | PROTEIN KINASE, CELL CYCLE, COMPLEX, PHOSPHORYLATION, TRANSFERASE
3qhr:A (PRO45) to (GLN287) STRUCTURE OF A PCDK2/CYCLINA TRANSITION-STATE MIMIC | KINASE CATALYTIC DOMAIN, PROTEIN KINASE, CYCLIN, PHOSPHORYLATED THR- 160, TRANSFERASE-PROTEIN BINDING COMPLEX
3qhr:C (PRO45) to (GLN287) STRUCTURE OF A PCDK2/CYCLINA TRANSITION-STATE MIMIC | KINASE CATALYTIC DOMAIN, PROTEIN KINASE, CYCLIN, PHOSPHORYLATED THR- 160, TRANSFERASE-PROTEIN BINDING COMPLEX
3qhw:A (PRO45) to (GLN287) STRUCTURE OF A PCDK2/CYCLINA TRANSITION-STATE MIMIC | KINASE CATALYTIC DOMAIN, PROTEIN KINASE, CYCLIN, PHOSPHORYLATED THR- 160, PHOSPHORYLATED ON THR-160, TRANSFERASE-PROTEIN BINDING COMPLEX
3qhw:C (PRO45) to (GLN287) STRUCTURE OF A PCDK2/CYCLINA TRANSITION-STATE MIMIC | KINASE CATALYTIC DOMAIN, PROTEIN KINASE, CYCLIN, PHOSPHORYLATED THR- 160, PHOSPHORYLATED ON THR-160, TRANSFERASE-PROTEIN BINDING COMPLEX
4uxl:A (THR1987) to (SER2229) STRUCTURE OF HUMAN ROS1 KINASE DOMAIN IN COMPLEX WITH PF-06463922 | TRANSFERASE, INHIBITOR, ROS
4uy9:A (ASP180) to (SER409) STRUCTURE OF MLK1 KINASE DOMAIN WITH LEUCINE ZIPPER 1 | MLK FAMILY, MLK1 AND MLK3 SUBTYPE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, SH3 DOMAIN, TRANSFERASE
3r22:A (GLU175) to (HIS380) DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE- SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I) | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r30:A (PRO99) to (HIS322) MK2 KINASE BOUND TO COMPOUND 2 | KINASE DOMAIN WITH BOUND INHIBITOR, KINASE DOMAIN, PHOSPHOTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fr4:A (GLU64) to (LYS292) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4fr4:B (GLU64) to (PHE278) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4fr4:C (GLU64) to (PHE278) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4fr4:D (GLU64) to (PHE278) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4fr4:E (GLU64) to (PHE278) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4fr4:F (GLU64) to (PHE278) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4fux:A (GLN60) to (SER264) CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH E75 | TRANSFERASE
4g3c:A (VAL440) to (VAL660) CRYSTAL STRUCTURE OF APO MURINE NF-KAPPAB INDUCING KINASE (NIK) | NON-RD KINASE, PROTEIN SERINE/THREONINE KINASE, NF-KAPPAB, MAP3K14, TRANSFERASE
4g3d:D (ARG437) to (GLN657) CRYSTAL STRUCTURE OF HUMAN NF-KAPPAB INDUCING KINASE (NIK) | NON-RD KINASE, PROTEIN SERINE/THREONINE KINASE, NF-KAPPAB, MAP3K14, TRANSFERASE
4g6n:A (GLN60) to (SER264) CRYSTAL STRUCTURE OF THE ERK2 | TRANSFERASE
5ke0:A (HIS59) to (LEU265) DISCOVERY OF 1-1H-PYRAZOLO 4,3-C PYRIDINE-6-YL UREA INHIBITORS OF EXTRACELLULAR SIGNAL REGULATED KINASE ERK FOR THE TREATMENT OF CANCERS | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5l2w:A (PRO45) to (HIS283) THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK2/CYCLINE AND DINACICLIB. | CYCLIN-DEPENDENT KINASE, KINASE INHIBITOR, KINASE SELECTIVITY, TRANSFERASE-CELL CYCLE-INHIBITOR COMPLEX
5li1:A (ASP293) to (HIS519) STRUCTURE OF A PAR3-INHIBITORY PEPTIDE BOUND TO PKCIOTA CORE KINASE DOMAIN | APKC, POLARITY, COMPLEX, TRANSFERASE
5lxm:A (VAL174) to (HIS380) CRYSTAL STRUCTURE OF AURORA-A BOUND TO A HYDROCARBON-STAPLED PROTEOMIMETIC OF TPX2 | PROTEIN KINASE, PROTEOMIMETIC, STAPLED HELIX PEPTIDE, MITOSIS, TRANSFERASE
1nxk:C (PRO99) to (HIS322) CRYSTAL STRUCTURE OF STAUROSPORINE BOUND TO MAP KAP KINASE 2 | PROTEIN KINASE, MK2, PHOSPHORYLATION, STAUROSPORINE, TRANSFERASE
3f5g:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DEATH ASSOCIATED PROTEIN KINASE IN COMPLEX WITH ADP AND MG2+ | KINASE-ADP COMPLEX,, ALTERNATIVE SPLICING, ANK REPEAT, APOPTOSIS, ATP-BINDING, CALMODULIN-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1ogu:C (PRO45) to (GLN287) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
2pz5:A (THR524) to (ASN766) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549T MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2pz5:B (LYS526) to (ASN766) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549T MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
4iac:A (ILE85) to (HIS294) X-RAY STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH HIGH MG2+ CONCENTRATION, AMP-PCP AND PSEUDO-SUBSTRATE PEPTIDE SP20 | KINASE, PHOSPHORYLATION, AUTO-PHOSPHORYLATED, TRANSFERASE-PEPTIDE COMPLEX
4ie9:A (ILE85) to (ALA298) BOVINE PKA C-ALPHA IN COMPLEX WITH 3-PYRIDYLMETHYL-5-METHYL-1H- PYRAZOLE-3-CARBOXYLATE | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ii5:A (PRO45) to (GLN287) STRUCTURE OF PCDK2/CYCLINA BOUND TO ADP AND 1 MAGNESIUM ION | ADP AND MAGNESIUM BINDING, T160 PHOSPHORYLATION, TRANSFERASE-CELL CYCLE COMPLEX
4ii5:C (PRO45) to (GLN287) STRUCTURE OF PCDK2/CYCLINA BOUND TO ADP AND 1 MAGNESIUM ION | ADP AND MAGNESIUM BINDING, T160 PHOSPHORYLATION, TRANSFERASE-CELL CYCLE COMPLEX
4yo4:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 CATALYTIC DOMAIN IN COMPLEX WITH THE HINGE BINDING FRAGMENT PHTHALAZINE | TRANSFERASE
4ypd:A (ARG58) to (HIS272) CRYSTAL STRUCTURE OF DAPK1 CATALYTIC DOMAIN IN COMPLEX WITH THE HINGE BINDING FRAGMENT 4-METHYLPYRIDAZINE | TRANSFERASE
2f2c:B (PRO55) to (HIS297) X-RAY STRUCTURE OF HUMAN CDK6-VCYCLINWITH THE INHIBITOR AMINOPURVALANOL | SMALL MOLECULE INHIBITOR BOUND BETWEEN N-TERMINAL AND C-TERMINAL DOMAIN OF KINASE, CELL CYCLE-TRANSFERASE COMPLEX
2vgp:A (VAL134) to (HIS340) CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR | NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, TRANSFERASE, COILED COIL, CELL DIVISION, KINASE, CANCER, INCENP, NUCLEUS, MITOSIS, AURORA B, METAL-BINDING, AMINOTHIAZOLE, PHOSPHORYLATION, MAGNESIUM, CELL CYCLE, CENTROMERE, MICROTUBULE
1gjo:A (THR524) to (THR764) THE FGFR2 TYROSINE KINASE DOMAIN | TRANSFERASE, TYROSINE KINASE, FGFR2 RECEPTOR
2vo6:A (ILE85) to (ALA298) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 4-(4- CHLOROBENZYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDIN- 4-YLAMINE | TRANSFERASE, LIPOPROTEIN, ATP-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, CAMP, KINASE, NUCLEUS, MYRISTATE, CYTOPLASM
1smh:A (ILE85) to (HIS294) PROTEIN KINASE A VARIANT COMPLEX WITH COMPLETELY ORDERED N- TERMINAL HELIX | PKA; PROTEIN KINASE A; CAMP-DEPENDENT PROTEIN KINASE; PHOSPHORYLATION; SER10; MYRISTOYLATION; POSTTRANSLATIONAL MODIFICATION; SIGNALING; MEMBRANE, ALPHA HELIX, SIGNALING PROTEIN,TRANSFERASE/INHIBITOR COMPLEX
1svh:A (GLN84) to (ALA298) CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITH AZEPANE DERIVATIVE 8 | KINASE-INHIBITOR-COMPLEX, SERINE/THREONINE-PROTEIN KINASE, BALANOL DERIVATIVE, TRANSFERASE
1gy3:A (PRO45) to (GLN287) PCDK2/CYCLIN A IN COMPLEX WITH MGADP, NITRATE AND PEPTIDE SUBSTRATE | TRANSFERASE-TRANSFERASE SUBSTRATE COMPLEX, CELL CYCLE REGULATORY PROTEIN KINASE, THR160-PHOSPHO-CYCLIN DEPENDENT PROTEIN KINASE 2 IN ASSOCIATION WITH CYCLIN A, TRANSFERASE- TRANSFERASE SUBSTRATE COMPLEX
2hel:A (ASP661) to (ASN884) CRYSTAL STRUCTURE OF A MUTANT EPHA4 KINASE DOMAIN (Y742A) | TYR KINASE, ACTIVATION, SIGNALING PROTEIN, TRANSFERASE
2wpa:A (PRO45) to (HIS283) OPTIMISATION OF 6,6-DIMETHYL PYRROLO 3,4-C PYRAZOLES: IDENTIFICATION OF PHA-793887, A POTENT CDK INHIBITOR SUITABLE FOR INTRAVENOUS DOSING | SERINE/THREONINE-PROTEIN 2 KINASE, CYCLIN, MITOSIS, CELL CYCLE, TRANSFERASE, ATP-BINDING, PHOSPHOPROTEIN,
2wpa:C (PRO45) to (GLN287) OPTIMISATION OF 6,6-DIMETHYL PYRROLO 3,4-C PYRAZOLES: IDENTIFICATION OF PHA-793887, A POTENT CDK INHIBITOR SUITABLE FOR INTRAVENOUS DOSING | SERINE/THREONINE-PROTEIN 2 KINASE, CYCLIN, MITOSIS, CELL CYCLE, TRANSFERASE, ATP-BINDING, PHOSPHOPROTEIN,
2x1n:A (PRO45) to (HIS283) TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN | INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, CELL DIVISION
2x1n:C (PRO45) to (GLN287) TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN | INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, CELL CYCLE, CELL DIVISION
1j3h:A (GLN84) to (HIS294) CRYSTAL STRUCTURE OF APOENZYME CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT | CRYSTAL STRUCTURE, APOENZYME, CAMP-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT, OPEN CONFORMATION, PREFORMED ACTIVE SITE, TRANSFERASE
1j3h:B (GLU86) to (HIS294) CRYSTAL STRUCTURE OF APOENZYME CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT | CRYSTAL STRUCTURE, APOENZYME, CAMP-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT, OPEN CONFORMATION, PREFORMED ACTIVE SITE, TRANSFERASE
1jks:A (SER57) to (HIS272) 1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE | TRANSFERASE
5av2:A (SER57) to (HIS272) CRYSTAL STRUCTURE OF DAPK1-KAEMPFEROL COMPLEX IN THE PRESENCE OF BROMIDE IONS. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
1kwp:A (PRO99) to (LYS307) CRYSTAL STRUCTURE OF MAPKAP2 | MAPKAP2, PROTEIN KINASE, SIGNAL TRANSDUCTION, TRANSFERASE
1kwp:B (LYS100) to (HIS322) CRYSTAL STRUCTURE OF MAPKAP2 | MAPKAP2, PROTEIN KINASE, SIGNAL TRANSDUCTION, TRANSFERASE
3kc3:C (CYS98) to (HIS322) MK2 COMPLEXED TO INHIBITOR N4-(7-(BENZOFURAN-2-YL)-1H-INDAZOL-5-YL) PYRIMIDINE-2,4-DIAMINE | MAPKAP-K2, MK2, TNFALPHA, DIAMINOPYRIMIDINE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3a2c:E (CYS98) to (LEU305) CRYSTAL STRUCTURE OF A PYRAZOLOPYRIMIDINE INHIBITOR COMPLEX BOUND TO MAPKAP KINASE-2 (MK2) | GLY-RICH LOOP FORMED, AIPHA-HELIX, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3a2c:H (CYS98) to (LEU305) CRYSTAL STRUCTURE OF A PYRAZOLOPYRIMIDINE INHIBITOR COMPLEX BOUND TO MAPKAP KINASE-2 (MK2) | GLY-RICH LOOP FORMED, AIPHA-HELIX, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3a2c:K (CYS98) to (HIS322) CRYSTAL STRUCTURE OF A PYRAZOLOPYRIMIDINE INHIBITOR COMPLEX BOUND TO MAPKAP KINASE-2 (MK2) | GLY-RICH LOOP FORMED, AIPHA-HELIX, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1ydr:E (ILE85) to (ALA298) STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5- ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE | COMPLEX (PHOSPHOTRANSFERASE/INHIBITOR), TRANSFERASE, CAMP, PHOSPHORYLATION, ISOQUINOLINE SULFONAMIDE, SERINE/THREONINE- PROTEIN KINASE, ATP-BINDING
4ann:A (PHE45) to (GLN204) CRYSTAL STRUCTURE STAPHYLOCOCCUS AUREUS ESSB CYTOPLASMIC FRAGMENT | MEMBRANE PROTEIN, MEMBRANE SECRETION, ESS TYPE VII SECRETION SYSTEM, VIRULENCE
5dyl:A (GLN575) to (HIS788) CRYSTAL STRUCTURE OF PVX_084705 | TRANSFERASE, KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
3lvp:A (MET1041) to (SER1265) CRYSTAL STRUCTURE OF BISPHOSPHORYLATED IGF1-R KINASE DOMAIN (2P) IN COMPLEX WITH A BIS-AZAINDOLE INHIBITOR | PROTEIN KINASE, TYROSINE KINASE, TYROSINE PHOSPHORYLATION, PROTEIN- SUBSTRATE COMPLEX, TRANSFERASE
4bco:C (PRO45) to (GLN287) STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4- HETEROARYL-PYRIMIDINE INHIBITOR | TRANSFERASE-CELL CYCLE COMPLEX, CDK-CYCLIN COMPLEX, CYCLIN-INHIBITOR, STRUCTURE-BASED DRUG DESIGN
4bib:A (LEU722) to (LYS939) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
4bib:B (GLN720) to (LYS939) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
3bhu:A (PRO45) to (GLN287) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR MERIOLIN 5 | SER/THR PROTEIN KINASE, TRANSFERASE, PHOSPHORYLATION, CELL CYCLE, ATP-BINDING, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, CYCLIN
3bhv:A (PRO45) to (GLN287) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR VARIOLIN B | SER/THR PROTEIN KINASE, TRANSFERASE, PHOSPHORYLATION, CELL CYCLE, ATP-BINDING, CELL DIVISION, MITOSIS, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, CYCLIN
5fet:A (GLN575) to (GLY792) CRYSTAL STRUCTURE OF PVX_084705 IN PRESENCE OF COMPOUND 2 | AGC KINASE, PKG, STRUCTURAL GENOMICS, MALARIA, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4cff:A (VAL57) to (HIS265) STRUCTURE OF FULL LENGTH HUMAN AMPK IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A THIENOPYRIDONE DERIVATIVE (A-769662) | TRANSFERASE, NUCLEOTIDE-BINDING, STAUROSPORINE-BINDING, SERINE/THREONINE-PROTEIN KINASE, ACTIVATOR, CARBOHYDRATE BINDING MODULE (CBM)
4cfu:A (PRO45) to (GLN287) STRUCTURE-BASED DESIGN OF C8-SUBSTITUTED O6- CYCLOHEXYLMETHOXYGUANINE CDK1 AND 2 INHIBITORS. | TRANSFERASE, STRUCTURE-BASED DRUG DESIGN, CONFORMATIONAL RESTRAINT, REVERSED BINDING MODE
3ddp:C (PRO45) to (HIS283) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR CR8 | SER/THR PROTEIN KINASE; PHOSPHORYLATION; CELL CYCLE, ATP- BINDING, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, CYCLIN, CYTOPLASM, NUCLEUS, TRANSFERASE/CELL CYCLE COMPLEX
3ddq:A (PRO45) to (GLN287) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR ROSCOVITINE | SER/THR PROTEIN KINASE; TRANSFERASE; PHOSPHORYLATION; CELL CYCLE, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, CYCLIN, CYTOPLASM, NUCLEUS, TRANSFERASE/CELL CYCLE COMPLEX
3ddq:C (PRO45) to (GLN287) STRUCTURE OF PHOSPHORYLATED THR160 CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR ROSCOVITINE | SER/THR PROTEIN KINASE; TRANSFERASE; PHOSPHORYLATION; CELL CYCLE, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, CYCLIN, CYTOPLASM, NUCLEUS, TRANSFERASE/CELL CYCLE COMPLEX
4d55:A (SER461) to (LEU685) FOCAL ADHESION KINASE CATALYTIC DOMAIN | TRANSFERASE, KINASE INHIBITOR, ATP-BINDING, INTEGRIN SIGNALING
4fx3:A (PRO45) to (GLN287) CRYSTAL STRUCTURE OF THE CDK2/CYCLIN A COMPLEX WITH OXINDOLE INHIBITOR | COMPLEX (TRANSFERASE-CYCLIN), TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fx3:C (PRO45) to (GLN287) CRYSTAL STRUCTURE OF THE CDK2/CYCLIN A COMPLEX WITH OXINDOLE INHIBITOR | COMPLEX (TRANSFERASE-CYCLIN), TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5lih:B (GLN300) to (LYS533) STRUCTURE OF A PEPTIDE-SUBSTRATE BOUND TO PKCIOTA CORE KINASE DOMAIN | APKC, POLARITY, COMPLEX, TRANSFERASE