2anw:A (GLN50) to (THR229) EXPRESSION, CRYSTALLIZATION AND THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS | TRYPSIN-LIKE SERINE PROTEASE; ENZYMATICALLY DEGLYCOSYLATED, BLOOD CLOTTING, HYDROLASE
2oq5:A (THR65) to (THR229) CRYSTAL STRUCTURE OF DESC1, A NEW MEMBER OF THE TYPE II TRANSMEMBRANE SERINE PROTEINASES FAMILY | TYPE II TRANS-MEMBRANE SERINE PROTEINASES, TRYPSIN-LIKE SERINE PROTEASE, TUMOR MARKER, HYDROLASE
2p3t:B (LYS65) to (THR229) CRYSTAL STRUCTURE OF HUMAN FACTOR XA COMPLEXED WITH 3- CHLORO-4-(2-METHYLAMINO-IMIDAZOL-1-YLMETHYL)-THIOPHENE-2- CARBOXYLIC ACID [4-CHLORO-2-(5-CHLORO-PYRIDIN-2- YLCARBAMOYL)-6-METHOXY-PHENYL]-AMIDE | PROTEIN INHIBITOR COMPLEX, NONAMIDINE, COAGULATION COFACTOR, PROTEASE, BLOOD CLOTTING
4x1p:U (GLU86) to (THR229) THE CRYSTAL STRUCTURE OF MUPAIN-1-17 IN COMPLEX WITH MURINISED HUMAN UPA AT PH4.6 | SERINE PROTEASE, PEPTIDIC INHIBITOR, UPA, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bm2:B (GLN50) to (THR229) HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL- PHENYL)-PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)- METHANONE | SERINE PROTEASE INHIBITOR, GLYCOPROTEIN, HYDROLASE, POLYMORPHISM, PROTEASE, SERINE PROTEASE
1o5e:H (TRP65) to (THR229) DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA) | SRCR, SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN, SERINE PROTEASE ALA190 UPA, S1 SITE, SELECTIVITY, CONSERVED WATER DISPLACEMENT HYDROGEN BOND DEFICIT, TRYPSIN, THROMBIN, HEPSIN, FACTOR VIIA, SERINE PROTEASE, HYDROLASE
1o5f:H (TRP65) to (THR229) DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA) | SRCR, SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN, SERINE PROTEASE ALA190 UPA, S1 SITE, SELECTIVITY, CONSERVED WATER DISPLACEMENT HYDROGEN BOND DEFICIT, TRYPSIN, THROMBIN, HEPSIN, FACTOR VIIA, SERINE PROTEASE, HYDROLASE
4x6p:A (GLN50) to (THR229) FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR (2E)-N-{(1S)-1-[4-(3-AMINO-1H-INDAZOL-6-YL)-1H-IMIDAZOL-2- YL]-2-PHENYLETHYL}-3-[5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL]PROP-2- ENAMIDE | SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bru:P (THR64) to (THR229) STRUCTURE OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH THE ELASTASE INHIBITOR GR143783 | SERINE PROTEASE, HYDROLASE
1bui:A (TYR64) to (VAL229) STRUCTURE OF THE TERNARY MICROPLASMIN-STAPHYLOKINASE-MICROPLASMIN COMPLEX: A PROTEINASE-COFACTOR-SUBSTRATE COMPLEX IN ACTION | PLASMIN, STAPHYLOKINASE, SERINE PROTEINASE, FIBRINOLYSIS, COFACTOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1okx:A (THR67) to (THR239) BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A | PROTEASE, ELASTASE, INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1okx:B (THR67) to (THR239) BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A | PROTEASE, ELASTASE, INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1owh:A (GLU91) to (THR245) SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE | PLASMINOGEN ACTIVATION, HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, KRINGLE, EGF-LIKE DOMAIN
3fvf:B (TYR64) to (THR229) THE CRYSTAL STRUCTURE OF PROSTASIN COMPLEXED WITH CAMOSTAT AT 1.6 ANGSTROMS RESOLUTION | PROSTASIN, HCAP-1, CHANNEL ACTIVATING PROTEASE, INHIBITOR, SERINE PROTEASE, ENAC, CELL MEMBRANE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, TRANSMEMBRANE, ZYMOGEN
3fzz:A (MET71) to (THR232) STRUCTURE OF GRC | HYDROLASE, CYTOLYSIS, PROTEASE, SERINE PROTEASE, ZYMOGEN
3fzz:B (MET71) to (THR232) STRUCTURE OF GRC | HYDROLASE, CYTOLYSIS, PROTEASE, SERINE PROTEASE, ZYMOGEN
1p57:B (TRP65) to (THR229) EXTRACELLULAR DOMAIN OF HUMAN HEPSIN | SRCR, SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2cga:B (ASP64) to (ALA229) BOVINE CHYMOTRYPSINOGEN A. X-RAY CRYSTAL STRUCTURE ANALYSIS AND REFINEMENT OF A NEW CRYSTAL FORM AT 1.8 ANGSTROMS RESOLUTION | HYDROLASE(ZYMOGEN)
4is5:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF THE LIGAND-FREE INACTIVE MATRIPTASE | BETA BARREL, SERINE PROTEASE, EPITHELIUM, HYDROLASE
4isl:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF THE INACTIVE MATRIPTASE IN COMPLEX WITH ITS INHIBITOR HAI-1 | BETA BARREL, SERINE PROTEASE INHIBITOR, EPITHELIUM, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1pyt:C (THR463) to (THR629) TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C | TERNARY COMPLEX (ZYMOGEN), SERINE PROTEINASE, C-TERMINAL PEPTIDASE
1eax:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MTSP1 (MATRIPTASE) | HYDROLASE, SERINE PROTEINASE, MATRIX DEGRADATION
4y8x:A (GLN50) to (THR229) FACTOR XIA IN COMPLEX WITH THE INHIBITOR METHYL (4-{4-CHLORO-2-[(1S)- 1-({(2E)-3-[5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL]PROP-2-ENOYL}AMINO)- 2-PHENYLETHYL]-1H-IMIDAZOL-5-YL}PHENYL)CARBAMATE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4y8z:A (GLN50) to (THR229) FACTOR XIA IN COMPLEX WITH THE INHIBITOR (2E)-N-[(1S)-1-[5-CHLORO-4- (4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-6-YL)-1H-IMIDAZOL-2-YL]-3-(4- METHYLPIPERAZIN-1-YL)-3-OXOPROPYL]-3-[5-CHLORO-2-(1H-TETRAZOL-1-YL) PHENYL]PROP-2-ENAMIDE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gym:B (TYR64) to (THR229) STRUCTURE OF PROSTASIN IN COMPLEX WITH APROTININ | PROSTASIN, HCAP1, CHANNEL ACTIVATING, APROTININ, INHIBITION, DISULFIDE BOND, PHARMACEUTICAL, PROTEASE INHIBITOR, SECRETED, SERINE PROTEASE INHIBITOR, CELL MEMBRANE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SERINE PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE/INHIBITOR COMPLEX
1ejn:A (GLU86) to (THR229) UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX | HUMAN, UPA, PLASMINOGEN ACTIVATOR, UROKINASE, INHIBITOR COMPLEX, HYDROLASE
1ekb:B (TRP64) to (ALA229) THE SERINE PROTEASE DOMAIN OF ENTEROPEPTIDASE BOUND TO INHIBITOR VAL- ASP-ASP-ASP-ASP-LYS-CHLOROMETHANE | ENTEROPEPTIDASE, TRYPSINOGEN ACTIVATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1f5k:U (GLU86) to (THR229) UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-BENZAMIDINE COMPLEX | UROKINASE, INHIBITOR, SERINE PROTEASE, HUMAN, HYDROLASE
1f5l:A (GLU86) to (THR229) UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX | UROKINASE, INHIBITOR, SERINE PROTEASE, HUMAN, HYDROLASE
2uwo:A (LYS65) to (THR229) SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA | TARGET HOPPING, SERINE PROTEASE, EGF-LIKE DOMAIN, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE, BLOOD COAGULATION, GAMMA- CARBOXYGLUTAMIC ACID, CLEAVAGE ON PAIR OF BASIC RESIDUES
4jyt:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR | MATRIPTASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jzi:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR". | MATRIPTASE, INHIBITOR, COMPLEX STRUCTURE, HYDROLASE
1fon:B (THR50) to (THR224) CRYSTAL STRUCTURE OF BOVINE PROCARBOXYPEPTIDASE A-S6 SUBUNIT III, A HIGHLY STRUCTURED TRUNCATED ZYMOGEN E | TRUNCATED ZYMOGEN E, SERINE PROTEASE
2f9n:B (GLN50) to (THR229) CRYSTAL STRUCTURE OF THE RECOMBINANT HUMAN ALPHA I TRYPTASE MUTANT K192Q/D216G IN COMPLEX WITH LEUPEPTIN | SERINE PROTEINASE, LEUPEPTIN, TRYPSIN-LIKE, DIFUCOSYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f9n:D (GLN50) to (THR229) CRYSTAL STRUCTURE OF THE RECOMBINANT HUMAN ALPHA I TRYPTASE MUTANT K192Q/D216G IN COMPLEX WITH LEUPEPTIN | SERINE PROTEINASE, LEUPEPTIN, TRYPSIN-LIKE, DIFUCOSYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2vin:A (GLU86) to (THR229) FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PLASMINOGEN ACTIVATION, EGF-LIKE DOMAIN, BLOOD COAGULATION, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, FIBRINOLYSIS, KRINGLE, ZYMOGEN, SECRETED, PROTEASE, HYDROLASE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, PHARMACEUTICAL, SERINE PROTEASE, PHOSPHORYLATION
2vio:A (GLU86) to (THR229) FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PLASMINOGEN ACTIVATION, EGF-LIKE DOMAIN, BLOOD COAGULATION, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, FIBRINOLYSIS, KRINGLE, ZYMOGEN, SECRETED, PROTEASE, HYDROLASE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, PHARMACEUTICAL, SERINE PROTEASE, PHOSPHORYLATION
2vip:A (GLU86) to (THR229) FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PLASMINOGEN ACTIVATION, EGF-LIKE DOMAIN, BLOOD COAGULATION, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, FIBRINOLYSIS, KRINGLE, ZYMOGEN, SECRETED, PROTEASE, HYDROLASE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, PHARMACEUTICAL, SERINE PROTEASE, PHOSPHORYLATION
2viw:A (GLU86) to (THR229) FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PLASMINOGEN ACTIVATION, EGF-LIKE DOMAIN, BLOOD COAGULATION, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, FIBRINOLYSIS, KRINGLE, ZYMOGEN, SECRETED, PROTEASE, HYDROLASE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, PHARMACEUTICAL, SERINE PROTEASE, PHOSPHORYLATION
2fs8:B (GLN50) to (THR229) HUMAN BETA-TRYPTASE II WITH INHIBITOR CRA-29382 | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
2fs8:C (GLN50) to (THR229) HUMAN BETA-TRYPTASE II WITH INHIBITOR CRA-29382 | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
2fs8:D (GLN50) to (THR229) HUMAN BETA-TRYPTASE II WITH INHIBITOR CRA-29382 | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
2fs9:A (GLN50) to (THR229) HUMAN BETA TRYPTASE II WITH INHIBITOR CRA-28427 | SERINE PROTEASE, SERINE PROTEINASE, 28427, HYDROLASE
2fs9:B (GLN50) to (THR229) HUMAN BETA TRYPTASE II WITH INHIBITOR CRA-28427 | SERINE PROTEASE, SERINE PROTEINASE, 28427, HYDROLASE
2fs9:C (GLN50) to (THR229) HUMAN BETA TRYPTASE II WITH INHIBITOR CRA-28427 | SERINE PROTEASE, SERINE PROTEINASE, 28427, HYDROLASE
1sc8:U (GLU86) to (THR229) UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-J435 COMPLEX | UROKINASE, INHIBITOR, SERINE PROTEASE, HUMAN, HYDROLASE
1gl1:C (ASP64) to (ALA229) STRUCTURE OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-C, AN INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA | HYDROLASE/INHIBITOR, COMPLEX (PROTEASE/INHIBITOR), HYDROLASE, SERINE PROTEASE, SERINE PROTEASE INHIBITOR
2fww:A (GLN50) to (THR229) HUMAN BETA-TRYPTASE II COMPLEXED WITH 4-PIPERIDINEBUTYRATE TO MAKE ACYLENZYME | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
2fww:C (GLN50) to (THR229) HUMAN BETA-TRYPTASE II COMPLEXED WITH 4-PIPERIDINEBUTYRATE TO MAKE ACYLENZYME | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
3v7t:A (GLN52) to (THR243) CRYSTAL STRUCTURE OF HUMAN BETA-TRYPTASE COMPLEXED WITH A SYNTHETIC INHIBITOR WITH A TROPANYLAMIDE SCAFFOLD | TRYPTASE, SERINE PROTEASE, TETRAMER, PROTEIN-LIGAND COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v7t:B (GLN52) to (THR243) CRYSTAL STRUCTURE OF HUMAN BETA-TRYPTASE COMPLEXED WITH A SYNTHETIC INHIBITOR WITH A TROPANYLAMIDE SCAFFOLD | TRYPTASE, SERINE PROTEASE, TETRAMER, PROTEIN-LIGAND COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v7t:C (GLN52) to (THR243) CRYSTAL STRUCTURE OF HUMAN BETA-TRYPTASE COMPLEXED WITH A SYNTHETIC INHIBITOR WITH A TROPANYLAMIDE SCAFFOLD | TRYPTASE, SERINE PROTEASE, TETRAMER, PROTEIN-LIGAND COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v7t:D (GLN52) to (THR243) CRYSTAL STRUCTURE OF HUMAN BETA-TRYPTASE COMPLEXED WITH A SYNTHETIC INHIBITOR WITH A TROPANYLAMIDE SCAFFOLD | TRYPTASE, SERINE PROTEASE, TETRAMER, PROTEIN-LIGAND COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1sqt:A (GLU78) to (THR231) SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE | PLASMINOGEN ACTIVATION, HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, KRINGLE, EGF-LIKE DOMAIN
2gdd:A (GLN50) to (THR229) HUMAN BETA II TRYPTASE WITH INHIBITOR CRA-27592 | SERINE PROTEASE, HYDROLASE
2gdd:B (GLN50) to (THR229) HUMAN BETA II TRYPTASE WITH INHIBITOR CRA-27592 | SERINE PROTEASE, HYDROLASE
2gdd:C (GLN50) to (THR229) HUMAN BETA II TRYPTASE WITH INHIBITOR CRA-27592 | SERINE PROTEASE, HYDROLASE
2gdd:D (GLN50) to (THR229) HUMAN BETA II TRYPTASE WITH INHIBITOR CRA-27592 | SERINE PROTEASE, HYDROLASE
4zkn:U (ASP63) to (THR229) THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH UPA AT PH5.5 | PEPTIDES INHIBITOR, UPA, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zko:U (TYR64) to (THR229) THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH UPA AT PH7.4 | PEPTIDES INHIBITOR, UPA, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zks:U (GLU86) to (THR229) THE CRYSTAL STRUCTURE OF UPAIN-1-W3A IN COMPLEX WITH INACTIVE UPA (UPA-S195A) AT PH7.4 | PEPTIDES INHIBITOR, UPA, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2gv6:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MATRIPTASE WITH INHIBITOR CJ-730 | MATRIPTASE, INHIBITOR, COMPLEX STRUCTURE, HYDROLASE
2gv7:A (TRP64) to (THR229) STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR CJ-672 | MATRIPTASE, INHIBITOR, COMPLEX STRUCTURE, HYDROLASE
3w94:A (TRP848) to (ALA1013) STRUCTURE OF ORYZIAS LATIPES ENTEROPEPTIDASE LIGHT CHAIN | SERINE PROTEASE, HYDROLASE
3w94:B (TRP848) to (ALA1013) STRUCTURE OF ORYZIAS LATIPES ENTEROPEPTIDASE LIGHT CHAIN | SERINE PROTEASE, HYDROLASE
2wyg:A (LYS65) to (THR229) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS | BLOOD CLOTTING, SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, HYDROLASE, HYDROXYLATION, ZYMOGEN
4mnv:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF BICYCLIC PEPTIDE UK729 BOUND AS AN ACYL-ENZYME INTERMEDIATE TO UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) | ACYL-ENZYME INTERMEDIATE, INHIBITOR, PROTEASE, 1,3,5- TRIS(BROMOMETHYL)BENZENE (TBMB) CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mnw:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK749 | COMPETITIVE INHIBITOR, BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, 1,3,5- TRIS(BROMOMETHYL)BENZENE (TBMB) CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mnx:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK811 | COMPETITIVE INHIBITOR, BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, 1,1', 1''-(1,3,5-TRIAZINANE-1,3,5-TRIYL)TRIPROP-2-EN-1-ONE (TATA) CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mny:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK903 | COMPETITIVE INHIBITOR, BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, N,N', N''-(BENZENE-1,3,5-TRIYL)TRIS(2-BROMOACETAMIDE) (TBAB) CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mny:B (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK903 | COMPETITIVE INHIBITOR, BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, N,N', N''-(BENZENE-1,3,5-TRIYL)TRIS(2-BROMOACETAMIDE) (TBAB) CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mpv:A (GLN67) to (THR258) HUMAN BETA-TRYPTASE CO-CRYSTAL STRUCTURE WITH (2R,4S)-N,N'-BIS[3-({4- [3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}CARBONYL)PHENYL]-4-HYDROXY-2- (2-HYDROXYPROPAN-2-YL)-5,5-DIMETHYL-1,3-DIOXOLANE-2,4-DICARBOXAMIDE | COFERON, ALPHA-HYDROXYKETONE, SMALL MOLECULE INHIBITOR, DRUG DISCOVERY, SELF-ASSEMBLY, CRYSTAL CATALYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mpw:B (GLN67) to (THR258) HUMAN BETA-TRYPTASE CO-CRYSTAL STRUCTURE WITH [(1,1,3,3- TETRAMETHYLDISILOXANE-1,3-DIYL)DI-1-BENZOFURAN-3,5-DIYL]BIS({4-[3- (AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE) | COFERON, ALPHA-HYDROXYKETONE, SMALL MOLECULE INHIBITOR, DRUG DISCOVERY, SELF-ASSEMBLY, CRYSTAL CATALYSIS, SILANOL, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1vja:U (GLU86) to (THR229) UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-JT463 COMPLEX | UROKINASE, INHIBITOR, SERINE PROTEASE, HUMAN, HYDROLASE
1w0z:U (GLU86) to (THR229) UROKINASE TYPE PLASMINOGEN ACTIVATOR | UROKINASE, HYDROLASE, PLASMINOGEN ACTIVATOR
1w11:U (GLU86) to (THR229) UROKINASE TYPE PLASMINOGEN ACTIVATOR | UROKINASE, HYDROLASE, PLASMINOGEN ACTIVATOR
1w14:U (GLU86) to (THR229) UROKINASE TYPE PLASMINOGEN ACTIVATOR | UROKINASE, HYDROLASE, PLASMINOGEN ACTIVATOR
2xtt:B (ILE63) to (THR229) BOVINE TRYPSIN IN COMPLEX WITH EVOLUTIONARY ENHANCED SCHISTOCERCA GREGARIA PROTEASE INHIBITOR 1 (SGPI-1-P02) | HYDROLASE, CATALYTIC MECHANISM, INHIBITION, IN VITRO EVOLUTION
4na8:A (GLN50) to (THR229) FACTOR XIA IN COMPLEX WITH THE INHIBITOR 5-AMINOCARBONYL-2-[3-[(2S, 4R)-6-CARBAMIMIDOYL-4-METHYL-4-PHENYL-2,3-DIHYDRO-1H-QUINOLIN-2- YL]PHENYL]BENZOIC ACID | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2jkh:A (LYS62) to (THR229) FACTOR XA - CATION INHIBITOR COMPLEX | PLASMA, CALCIUM, ZYMOGEN, SECRETED, PROTEASE, HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD COAGULATION, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
2y5f:A (LYS62) to (THR229) FACTOR XA - CATION INHIBITOR COMPLEX | BLOOD CLOTTING, PLASMA, ZYMOGEN, HYDROLASE, BLOOD COAGULATION, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN
2y5g:A (LYS62) to (THR229) FACTOR XA - CATION INHIBITOR COMPLEX | BLOOD CLOTTING, PLASMA, ZYMOGEN, HYDROLASE, BLOOD COAGULATION, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN
2y5h:A (LYS65) to (THR229) FACTOR XA - CATION INHIBITOR COMPLEX | BLOOD CLOTTING, PLASMA, ZYMOGEN, HYDROLASE, BLOOD COAGULATION, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN
1kyn:B (SER361) to (THR529) CATHEPSIN-G | SERINE PROTEASE, HYDROLASE
2za5:A (GLN52) to (THR243) CRYSTAL STRUCTURE OF HUMAN TRYPTASE WITH POTENT NON-PEPTIDE INHIBITOR | TRYPTASE, SERINE PROTEASE, TETRAMER, HYDROLASE
2za5:C (GLN52) to (THR243) CRYSTAL STRUCTURE OF HUMAN TRYPTASE WITH POTENT NON-PEPTIDE INHIBITOR | TRYPTASE, SERINE PROTEASE, TETRAMER, HYDROLASE
4a6l:A (GLN52) to (THR248) BETA-TRYPTASE INHIBITOR | HYDROLASE, INHIBITOR
4a6l:B (GLN52) to (THR248) BETA-TRYPTASE INHIBITOR | HYDROLASE, INHIBITOR
4a6l:C (GLN52) to (THR248) BETA-TRYPTASE INHIBITOR | HYDROLASE, INHIBITOR
4a6l:D (GLN52) to (THR248) BETA-TRYPTASE INHIBITOR | HYDROLASE, INHIBITOR
2zec:C (GLN52) to (THR243) POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TRYPTASE | TRYPTASE, SERINE PROTEASE, HYDROLASE
3k9x:D (ARG63) to (THR229) X-RAY CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH (S)-N-((2- METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL) ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE | SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF- LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING, BLOOD COAGULATION, DISULFIDE BOND, PROTEASE, SECRETED
4os1:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK601 (BICYCLIC 1) | BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, DISULFIDE BRIDGES, CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4os5:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK603 (BICYCLIC 2) | BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, DISULFIDE BRIDGES, CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4os7:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK607 (BICYCLIC) | BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, DISULFIDE BRIDGES, CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kl6:A (LYS65) to (THR229) DISCOVERY OF TETRAHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVE TAK-442: A POTENT, SELECTIVE AND ORALLY ACTIVE FACTOR XA INHIBITOR | COAGULATION FACTOR XA, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN
1ym0:A (VAL64) to (TYR228) CRYSTAL STRUCTURE OF EARTHWORM FIBRINOLYTIC ENZYME COMPONENT B: A NOVEL, GLYCOSYLATED TWO-CHAINED TRYPSIN | TWO CHAINS, GLYCOSYLATION, PYROGLUTAMATION, EIGHT-MEMBERED RING, CIS PEPTIDE BOND, HYDROLASE
4aoq:C (GLY68) to (THR230) CATIONIC TRYPSIN IN COMPLEX WITH MUTATED SPINACIA OLERACEA TRYPSIN INHIBITOR III (SOTI-III) (F14A) | HYDROLASE-INHIBITOR COMPLEX, MINIPROTEIN SCAFFOLD, KNOTTINS, SERINE PROTEASE INHIBITOR
1zhp:A (GLN48) to (THR229) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH BENZAMIDINE (S434A-T475A-K505 MUTANT) | FACTOR XI; BENZAMIDINE, HYDROLASE, BLOOD CLOTTING
1zr0:A (GLY62) to (THR229) CRYSTAL STRUCTURE OF KUNITZ DOMAIN 1 OF TISSUE FACTOR PATHWAY INHIBITOR-2 WITH BOVINE TRYPSIN | SERINE PROTEASE; COMPLEX OF SERINE PROTEASE/INHIBITOR; KUNITZ TYPE INHIBITOR, HYDROLASE/BLOOD CLOTTING COMPLEX
3m61:U (GLU86) to (THR229) CRYSTAL STRUCTURE OF COMPLEX OF UROKINASE AND A UPAIN-1 VARIANT(W3A) IN PH4.6 CONDITION | PROTEIN-LIGAND COMPLEX, DISULFIDE BOND, FIBRINOLYSIS, HYDROLASE, PLASMINOGEN ACTIVATION, SERINE PROTEASE-PEPTIDE COMPLEX, ALTERNATIVE SPLICING, BLOOD COAGULATION, EGF-LIKE DOMAIN, GLYCOPROTEIN, KRINGLE, PHARMACEUTICAL, PHOSPHOPROTEIN, POLYMORPHISM, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3mhw:U (GLU86) to (THR229) THE COMPLEX CRYSTAL STRUCTURE OF UROKIANSE AND 2- AMINOBENZOTHIAZOLE | HYDROLASE, BLOOD COAGULATION, FIBRINOLYSIS, PLASMINOGEN ACTIVATION
5exl:A (GLN50) to (THR229) FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-(AMINOMETHYL)-~{N}- [(1~{S})-1-[4-(3-OXIDANYL-1~{H}-INDAZOL-5-YL)PYRIDIN-2-YL]-2-PHENYL- ETHYL]CYCLOHEXANE-1-CARBOXAMIDE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5exm:A (GLN50) to (THR229) FACTOR XIA IN COMPLEX WITH THE INHIBITOR METHYL ~{N}-[4-[2-[(1~{S})-1- [[4-(AMINOMETHYL)CYCLOHEXYL]CARBONYLAMINO]-2-PHENYL-ETHYL]PYRIDIN-4- YL]PHENYL]CARBAMATE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4bnr:A (LEU64) to (THR230) EXTREMELY STABLE COMPLEX OF CRAYFISH TRYPSIN WITH BOVINE TRYPSIN INHIBITOR | HYDOLASE-INHIBITOR COMPLEX, PROTEASE, INHIBITION, ARTHROPODA, HEAT STABILITY, COMPLEX FORMATION
5f03:A (GLN50) to (THR229) TRYPTASE B2 IN COMPLEX WITH 5-(3-AMINOMETHYL-PHENOXYMETHYL)-3-[3-(2- CHLORO-PYRIDIN-3-YLETHYNYL)-PHENYL]-OXAZOLIDIN-2-ONE; COMPOUND WITH TRIFLUORO-ACETIC ACID | HUMAN TRYPTASE, SERINE PROTEINASE, HYDROLASE
5f03:B (GLN50) to (THR229) TRYPTASE B2 IN COMPLEX WITH 5-(3-AMINOMETHYL-PHENOXYMETHYL)-3-[3-(2- CHLORO-PYRIDIN-3-YLETHYNYL)-PHENYL]-OXAZOLIDIN-2-ONE; COMPOUND WITH TRIFLUORO-ACETIC ACID | HUMAN TRYPTASE, SERINE PROTEINASE, HYDROLASE
4dgj:A (TRP53) to (ALA221) STRUCTURE OF A HUMAN ENTEROPEPTIDASE LIGHT CHAIN VARIANT | SERINE PROTEASE, HYDROLASE
4dgj:B (LYS52) to (ALA221) STRUCTURE OF A HUMAN ENTEROPEPTIDASE LIGHT CHAIN VARIANT | SERINE PROTEASE, HYDROLASE
4dgj:C (TRP53) to (ALA221) STRUCTURE OF A HUMAN ENTEROPEPTIDASE LIGHT CHAIN VARIANT | SERINE PROTEASE, HYDROLASE
4dgj:D (TRP53) to (ALA221) STRUCTURE OF A HUMAN ENTEROPEPTIDASE LIGHT CHAIN VARIANT | SERINE PROTEASE, HYDROLASE
4djz:B (LYS515) to (SER682) CATALYTIC FRAGMENT OF MASP-1 IN COMPLEX WITH ITS SPECIFIC INHIBITOR DEVELOPED BY DIRECTED EVOLUTION ON SGCI SCAFFOLD | IN VITRO EVOLUTION, SPECIFIC INHIBITOR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4djz:D (LYS515) to (SER682) CATALYTIC FRAGMENT OF MASP-1 IN COMPLEX WITH ITS SPECIFIC INHIBITOR DEVELOPED BY DIRECTED EVOLUTION ON SGCI SCAFFOLD | IN VITRO EVOLUTION, SPECIFIC INHIBITOR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3e0n:B (TYR64) to (THR229) THE X-RAY STRUCTURE OF HUMAN PROSTASIN IN COMPLEX WITH DFFR- CHLOROMETHYL KETONE INHIBITOR | PROSTASIN, PROTEASE, CHLOROMETHYL-KETONE, CHANNEL, ENAC, CELL MEMBRANE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, SECRETED, SERINE PROTEASE, TRANSMEMBRANE, ZYMOGEN
3p8g:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MT-SP1 IN COMPLEX WITH BENZAMIDINE | HYDROLASE
3q3k:A (LYS65) to (THR229) FACTOR XA IN COMPLEX WITH A PHENYLENEDIAMINE DERIVATIVE | PROTEIN INHIBITOR COMPLEX, BLOOD COAGGULATION, CLEAVAGE OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN, HYDROXYLATION, PROTEASE, SECRETED, ZYMOGEN, GLYCOPROTEIN, HYDROLASE, BLOOD COAGGULATION FACTOR, SERINE PROTEASE, GAMMA-CARBOXYGLUTAMIC ACID, PLASMA, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fub:A (GLU79) to (THR232) CRYSTAL STRUCTURE OF THE UROKINASE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fuf:A (GLU79) to (THR232) CRYSTAL STRUCTURE OF THE UROKINASE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fui:A (GLU79) to (THR232) CRYSTAL STRUCTURE OF THE UROKINASE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5jpm:H (ASP496) to (THR670) STRUCTURE OF THE COMPLEX OF HUMAN COMPLEMENT C4 WITH MASP-2 REBUILT USING IMDFF | COMPLEMENT, IMMUNE SYSTEM, BLOOD
4gaw:A (SER64) to (ILE225) CRYSTAL STRUCTURE OF ACTIVE HUMAN GRANZYME H | SERINE PROTEASE, CYTOLYSIS, HYDROLASE, CYTOTOXIC GRANULES
2o8u:A (ASP63) to (THR229) CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q/S195A) IN COMPLEX WITH INHIBITORS | UROKINASE-TYPE PLASMINOGEN ACTIVATOR, BENZAMIDINE, PHENYLGUANIDINE, CONTACT AREA, HYDROLASE
4xsk:U (GLU86) to (THR229) STRUCTURE OF PAITRAP, AN UPA MUTANT | ANTAGONIST, PAI-1, UPA, BLOOD CLOTTING
4isn:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH ITS INHIBITOR HAI-1 | BETA BARREL, SERINE PROTEASE INHIBITOR, EPITHELIUM, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4iso:A (TRP64) to (THR229) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH ITS INHIBITOR HAI-1 | BETA BARREL, SERINE PROTEASE, INHIBITOR, EPITHELIUM, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2xc4:A (LYS65) to (THR229) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION FACTOR, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, HYDROLASE, HYDROXYLATION, ZYMOGEN
2j4i:A (LYS65) to (THR229) CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | BLOOD COAGULATION, CALCIUM, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, POLYMORPHISM, PROTEASE, SERINE PROTEASE, ZYMOGEN, COMPLEX
1w10:U (GLU86) to (THR229) UROKINASE TYPE PLASMINOGEN ACTIVATOR | UROKINASE, HYDROLASE, PLASMINOGEN ACTIVATOR
2zeb:A (GLN37) to (THR228) POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TRYPTASE | TRYPTASE, SERINE PROTEASE, HYDROLASE
2zeb:B (GLN37) to (THR228) POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TRYPTASE | TRYPTASE, SERINE PROTEASE, HYDROLASE
2zeb:D (GLN37) to (THR228) POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TRYPTASE | TRYPTASE, SERINE PROTEASE, HYDROLASE
4os2:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK602 (BICYCLIC 1) | BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, DISULFIDE BRIDGES, CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4os4:A (GLU86) to (THR229) CRYSTAL STRUCTURE OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) COMPLEXED WITH BICYCLIC PEPTIDE UK603 (BICYCLIC 1) | BICYCLIC PEPTIDE, INHIBITOR, PROTEASE, DISULFIDE BRIDGES, CYCLIZATION, EXTRACELLULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kid:U (ASP63) to (THR229) THE CRYSTAL STRUCTURES OF 2-AMINOBENZOTHIAZOLE-BASED INHIBITORS IN COMPLEXES WITH UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PROTEIN-LIGAND COMPLEX, DISULFIDE BOND, FIBRINOLYSIS, HYDROLASE, PLASMINOGEN ACTIVATION, SERINE PROTEASE
3ncl:A (TRP68) to (THR243) CRYSTAL STRUCTURE OF MT-SP1 BOUND TO BENZAMIDINE PHOSPHONATE INHIBITOR | PROTEINASE-INHIBITOR COMPLEX, SERINE PROTEINASE, BENZAMIDINE, PHOSPHONATE, SERINE ENDOPEPTIDASES, HYDROLASE
4d7g:A (GLN48) to (THR229) HUMAN FXIA IN COMPLEX WITH SMALL MOLECULE INHIBITORS. | HYDROLASE, SERINE PROTEASE