4gry:A (ASN303) to (GLY477) CRYSTAL STRUCTURE OF SHP1 CATALYTIC DOMAIN WITH SO4 | PHOSPHATASE DOMAIN, HYDROLASE
3eb1:A (ASN68) to (LYS237) CRYSTAL STRUCTURE PTP1B COMPLEX WITH SMALL MOLECULE INHIBITOR LZP-25 | PROTEIN TYROSINE PHOSPHATASE, PTP1B, INHIBITOR, CRYSTAL STRUCTURE, ACETYLATION, ENDOPLASMIC RETICULUM, HYDROLASE, MEMBRANE, OXIDATION, PHOSPHOPROTEIN, POLYMORPHISM, PROTEIN PHOSPHATASE
4gwf:B (ASN306) to (GLY483) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH Y279C MUTATION | ALPHA/BETA PROTEINS, SH2 DOMAIN, PHOSPHATASE DOMAIN, TYROSINE PHOSPHATASE SHP-2, HYDROLASE
1nny:A (ASN68) to (LYS237) POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 23 USING A LINKED-FRAGMENT STRATEGY | PROTEIN TYROSINE PHOSPHATASE FOLD, DUAL-SITE OXAMIC ACID INHIBITOR BOUND TO P-LOOP, HYDROLASE
4h1o:A (ASN306) to (GLY483) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH D61G MUTATION | ALPHA/BETA PROTEINS, SH2 DOMAIN, PHOSPHATASE DOMAIN, TYROSINE PHOSPHATASE SHP-2, HYDROLASE
2b4s:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF A COMPLEX BETWEEN PTP1B AND THE INSULIN RECEPTOR TYROSINE KINASE | HYDROLASE/TRANSFERASE, PHOSPHORYLATION, TYROSINE PROTEIN KINASE
2b4s:C (ASN68) to (ARG238) CRYSTAL STRUCTURE OF A COMPLEX BETWEEN PTP1B AND THE INSULIN RECEPTOR TYROSINE KINASE | HYDROLASE/TRANSFERASE, PHOSPHORYLATION, TYROSINE PROTEIN KINASE
1nwe:A (ASN68) to (ARG238) PTP1B R47C MODIFIED AT C47 WITH N-[4-(2-{2-[3-(2-BROMO- ACETYLAMINO)-PROPIONYLAMINO]-3-HYDROXY-PROPIONYLAMINO}- ETHYL)-PHENYL]-OXALAMIC ACID | HYDROLASE, ACETYLATION, PHOSPHORYLATION, PHOSPATASE, PHOSPHOTYROSINE MIMETIC
3s3f:A (ASN104) to (THR264) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PTP10D FROM DROSOPHILA MELANOGASTER WITH A SMALL MOLECULE INHIBITOR VANADATE | DIFFERENTIATION, NEUROGENESIS, SIGNAL TRANSDUCTION, DEVELOPMENTAL PROTEIN, HYDROLASE,PROTEIN PHOSPHATASE, PROTEIN TYROSINE PHOSPHATASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s3h:A (VAL106) to (THR264) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PTP10D FROM DROSOPHILA MELANOGASTER WITH A PHOSPHOPEPTIDE SUBSTRATE GP4 | DIFFERENTIATION, NEUROGENESIS, SIGNAL TRANSDUCTION, DEVELOPMENTAL PROTEIN, HYDROLASE, PROTEIN PHOSPHATASE, PROTEIN TYROSINE PHOSPHATASE
3s3h:B (VAL106) to (SER265) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PTP10D FROM DROSOPHILA MELANOGASTER WITH A PHOSPHOPEPTIDE SUBSTRATE GP4 | DIFFERENTIATION, NEUROGENESIS, SIGNAL TRANSDUCTION, DEVELOPMENTAL PROTEIN, HYDROLASE, PROTEIN PHOSPHATASE, PROTEIN TYROSINE PHOSPHATASE
4hjp:A (ASN303) to (GLY477) SHP-1 CATALYTIC DOMAIN WPD LOOP OPEN | PHOSPHATASE DOMAIN, HYDROLASE
2bij:A (ASN331) to (GLN494) CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED ENRICHED PHOSPHATASE) | PTPN5, STEP, PHOSPHATASE, HYDROLASE
2pbn:A (ASN910) to (ASP1082) CRYSTAL STRUCTURE OF THE HUMAN TYROSINE RECEPTOR PHOSPHATE GAMMA | STRUCTURAL GENOMICS, HYDROLASE, PSI-2, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC
2bv5:A (ASN331) to (GLN494) CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION | PTPN5, STEP, PHOSPHATASE, HYDROLASE
1bzh:A (ASN68) to (LYS237) CYCLIC PEPTIDE INHIBITOR OF HUMAN PTP1B | PHOSPHORYLATION-INHIBITOR COMPLEX, TYROSINE PHOSPHATASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1bzj:A (ASN68) to (ARG238) HUMAN PTP1B COMPLEXED WITH TPICOOH | PHOSPHORYLATION, INHIBITOR COMPLEX, PROTEIN TYROSINE PHOSPHATASE, HYDROLASE
2pi7:A (ASN1045) to (ASP1209) STRUCTURE OF THE CATALYTIC DOMAIN OF THE CHICK RETINAL NEURITE INHIBITOR-RECEPTOR PROTEIN TYROSINE PHOSPHATASE CRYP-2/CPTPRO | PROTEIN TYROSINE PHOSPHATASE, HYDROLASE
2pi7:B (ASN1045) to (ASP1209) STRUCTURE OF THE CATALYTIC DOMAIN OF THE CHICK RETINAL NEURITE INHIBITOR-RECEPTOR PROTEIN TYROSINE PHOSPHATASE CRYP-2/CPTPRO | PROTEIN TYROSINE PHOSPHATASE, HYDROLASE
1c84:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID | HYDROLASE, PHOSPHORYLATION, LIGAND, INHIBITOR
1c86:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V, D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H- THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | HYDROLASE, PHOSPHORYLATION, LIGAND, INHIBITOR
1c87:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3- C]PYRAN-3-CARBOXYLIC ACID | HYDROLASE, PHOSPHORYLATION, LIGAND, INHIBITOR
1c88:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO- THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID | HYDROLASE, PHOSPHORYLATION, LIGAND, INHIBITOR
3sr9:A (ASN1696) to (TYR1861) CRYSTAL STRUCTURE OF MOUSE PTPSIGMA | TYROSINE PHOSPHATASE, HYDROLASE
1p15:A (SER584) to (ALA746) CRYSTAL STRUCTURE OF THE D2 DOMAIN OF RPTPA | TRANSMEMBRANE, HYDROLASE, PHOSPHORYLATION
1p15:B (ASN582) to (ALA746) CRYSTAL STRUCTURE OF THE D2 DOMAIN OF RPTPA | TRANSMEMBRANE, HYDROLASE, PHOSPHORYLATION
2cfv:A (ASN1098) to (ASN1263) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J | HYDROLASE, RECEPTOR TYPE TYROSINE PHOSPHATASE J, PTPRJ, GLYCOPROTEIN, PROTEIN PHOSPHATASE
2qdc:A (ASN130) to (GLY294) CRYSTAL STRUCTURE OF THE HEPTP CATALYTIC DOMAIN D236A MUTANT | HEPTP, HUMAN HEMATOPOIETIC TYROSINE PHOSPHATASE CATALYTIC DOMAIN MUTANT, LC-PTP, PTPN7, HYDROLASE
2qdp:A (ASN130) to (LYS291) CRYSTAL STRUCTURE OF THE HEPTP CATALYTIC DOMAIN C270S MUTANT CRYSTALLIZED IN AMMONIUM ACETATE | HEPTP, HUMAN HEMATOPOIETIC TYROSINE PHOSPHATASE CATALYTIC DOMAIN MUTANT, LC-PTP, PTPN7, HYDROLASE
2qep:A (ASN802) to (LYS967) CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA) | PTPRN2, PTPRP, PHOGRIN, IA-2 BETA, AUTOANTIGEN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, HYDROLASE
1pa1:A (ASN568) to (ARG738) CRYSTAL STRUCTURE OF THE C215D MUTANT OF PROTEIN TYROSINE PHOSPHATASE 1B | PHOSPHATASE, CATALYTIC LOOP, ACTIVE-SITE MUTANT, HYDROLASE
2cm2:A (ASN68) to (LYS237) STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (P212121) | POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE
2cmc:A (ASN68) to (LYS237) STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS | POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE
2cng:A (ASN68) to (LYS239) STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE
4y14:A (ASN68) to (LYS237) STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH INHIBITOR (PTP1B:CPT157633) | TYROSINE INHIBITOR COMPLEX, HYDROLASE, PROTEIN BINDING, HYDROLASE- INHIBITOR COMPLEX
4y14:B (ASN68) to (LYS237) STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH INHIBITOR (PTP1B:CPT157633) | TYROSINE INHIBITOR COMPLEX, HYDROLASE, PROTEIN BINDING, HYDROLASE- INHIBITOR COMPLEX
1ptv:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE | HYDROLASE, ACETYLATION, PHOSPHORYLATION, PEPTIDE, COMPLEX (HYDROLASE/PEPTIDE) COMPLEX
1pty:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES | HYDROLASE, ACETYLATION, PHOSPHORYLATION, PEPTIDE, INHIBITION
1q6n:A (ASN568) to (LYS737) THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 4 | PHOSPHATASE, SECONDARY BINDING SITE, SELECTIVITY, HYDROLASE
1ecv:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID | HYDROLASE, PHOSPHORYLATION, LIGAND, INHIBITOR
1een:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G | HYDROLASE, ACETYLATION, PHOSPHORYLATION, PEPTIDE, INHIBITION
2shp:A (ASN306) to (GLY483) TYROSINE PHOSPHATASE SHP-2 | TYROSINE PHOSPHATASE, INSULIN SIGNALING, SH2 PROTEIN
2shp:B (ASN306) to (GLY483) TYROSINE PHOSPHATASE SHP-2 | TYROSINE PHOSPHATASE, INSULIN SIGNALING, SH2 PROTEIN
1qxk:A (ASN68) to (LYS237) MONOACID-BASED, CELL PERMEABLE, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | PROTEIN TYROSINE PHOSPHATASE 1B, PTP1B MONOACID-BASED AND CELL PERMEABLE, HYDROLASE
2f6w:A (ASN68) to (ARG238) PROTEIN TYROSINE PHOSPHATASE 1B WITH SULFAMIC ACID INHIBITORS | PTP1B, SULFAMIC ACIDS, TETRAHYDROISOQUINOLINE, PHOSPHATASE, TYROSINE, HYDROLASE
2f6y:A (ASN68) to (ARG238) PROTEIN TYROSINE PHOSPHATASE 1B WITH SULFAMIC ACID INHIBITORS | PTP1B, SULFAMIC ACIDS, TETRAHYDROISOQUINOLINE, PHOSPHATASE, TYROSINE, HYDROLASE
1g1f:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR) ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE | HYDROLASE (PHOSPHORYLATION), TYROSINE PHOSPHATASE, PEPTIDE COMPLEX, HYDROLASE, SIGNALING PROTEIN
1g1h:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR) RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE | HYDROLASE (PHOSPHORYLATION), TYROSINE PHOSPHATASE, PEPTIDE COMPLEX, HYDROLASE, SIGNALING PROTEIN
2veu:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR | MEMBRANE, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE, POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM
2fh7:A (ASN1450) to (ILE1609) CRYSTAL STRUCTURE OF THE PHOSPHATASE DOMAINS OF HUMAN PTP SIGMA | RECEPTOR PROTEIN TYROSINE PHOSPHATASE, DUAL DOMAIN PHOSPHATASE, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC, HYDROLASE
1gfy:A (ASN68) to (ARG238) RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA | HYDROLASE
3i36:A (ASN977) to (ASN1142) CRYSTAL STRUCTURE OF RAT PROTEIN TYROSINE PHOSPHATASE ETA CATALYTIC DOMAIN | PTP, TYROSINE PHOSPHATASE, HYDROLASE
2g59:A (ASN83) to (ASP247) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE FROM HOMO SAPIENS | PROTEIN TYROSINE PHOSPHATASE, DEPHOSPHORYLATION, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC, HYDROLASE
2g59:B (ASN83) to (ASP247) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE FROM HOMO SAPIENS | PROTEIN TYROSINE PHOSPHATASE, DEPHOSPHORYLATION, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC, HYDROLASE
1sug:A (ASN68) to (ARG238) 1.95 A STRUCTURE OF APO PROTEIN TYROSINE PHOSPHATASE 1B | WPD-LOOP CLOSED, WATER MOLECULE NETWORK, HYDROLASE
3i7z:A (ASN68) to (LYS237) PROTEIN TYROSINE PHOSPHATASE 1B - TRANSITION STATE ANALOG FOR THE FIRST CATALYTIC STEP | HYDROLASE, P-LOOP, WPD-LOOP, PROTEIN PHOSPHATASE, EGFR RECEPTOR, VANADATE, ACETYLATION, ENDOPLASMIC RETICULUM, MEMBRANE, OXIDATION, PHOSPHOPROTEIN, POLYMORPHISM
3i80:A (ASN68) to (LYS237) PROTEIN TYROSINE PHOSPHATASE 1B - TRANSITION STATE ANALOG FOR THE SECOND CATALYTIC STEP | HYDROLASE, P-LOOP, WPD-LOOP, PROTEIN PHOSPHATASE, VANADATE, ACETYLATION, ENDOPLASMIC RETICULUM, MEMBRANE, OXIDATION, PHOSPHOPROTEIN, POLYMORPHISM
2gp0:A (ASN130) to (GLY294) HEPTP CATALYTIC DOMAIN (RESIDUES 44-339), S225D MUTANT | HEPTP, HUMAN HEMAPOIETIC TYROSINE PHOSPHATASE CATALYTIC DOMAIN, PTPN7, HYDROLASE
2h4g:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PTP1B WITH MONOCYCLIC THIOPHENE INHIBITOR | PROTEIN-DRUG COMPLEX, HYDROLASE
2hb1:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PTP1B WITH MONOCYCLIC THIOPHENE INHIBITOR | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2hnp:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B | HYDROLASE(PHOSPHORYLATION)
2hnq:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B | HYDROLASE(PHOSPHORYLATION)
2i4h:A (ASN1759) to (SER1926) STRUCTURAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE BETA CATALYTIC DOMAIN CO-CRYSTALLIZED WITH A SULFAMIC ACID INHIBITOR | PROTEIN TYROSINE PHOSPHATASE, WPD-LOOP, SULFAMIC ACID, PHOSPHATASE, INHIBITOR, DRUG DESIGN, HYDROLASE
2i5x:A (ASN1759) to (SER1926) ENGINEERING THE PTPBETA CATALYTIC DOMAIN WITH IMPROVED CRYSTALLIZATION PROPERTIES | PROTEIN TYROSINE PHOSPHATASE, WPD-LOOP, DRUG DESIGN, PROTEIN ENGINEERING, HYDROLASE
2jjd:A (SER193) to (ALA357) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
2jjd:B (ASN483) to (ALA652) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
2jjd:C (ASN483) to (ALA652) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
2jjd:D (SER193) to (ALA357) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
2jjd:D (ASN483) to (ALA652) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
2jjd:F (SER193) to (ALA357) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
2jjd:F (ASN483) to (ALA652) PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM | TRANSMEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, CONSORTIUM, STRUCTURAL, PHOSPHATASE, GLYCOPROTEIN, SGC, PTPRE, MEMBRANE, GENOMICS, HYDROLASE
1wax:A (ASN68) to (ARG238) PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR | ACETYLATION, HYDROLASE, PHOSPHORYLATION, PROTEIN TYROSINE PHOSPHATASE, INHIBITORS
4nwf:A (ASN306) to (GLY483) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH N308D MUTATION | HYDROLASE
4nwf:B (ASN306) to (GLU481) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH N308D MUTATION | HYDROLASE
1xbo:A (ASN68) to (LYS237) PTP1B COMPLEXED WITH ISOXAZOLE CARBOXYLIC ACID | PROTEIN TYROSINE PHOSPHATASE 1B, PTP1B, ISOXAZOLE CARBOXYLIC ACID, HYDROLASE
2nv5:A (ASN1285) to (HIS1446) CRYSTAL STRUCTURE OF A C-TERMINAL PHOSPHATASE DOMAIN OF RATTUS NORVEGICUS ORTHOLOG OF HUMAN PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, D (PTPRD) | PHOSPHATASE, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC, HYDROLASE
1l8k:A (ASN70) to (LYS238) T CELL PROTEIN-TYROSINE PHOSPHATASE STRUCTURE | PROTEIN TYROSINE PHOSPHATASE, HYDROLASE
1lar:B (ASN1670) to (TYR1835) CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR | TYROSINE PHOSPHATEASE, LAR PROTEIN, HYDROLASE
2nz6:A (ASN1096) to (ASN1263) CRYSTAL STRUCTURE OF THE PTPRJ INACTIVATING MUTANT C1239S | HYDROLASE RECEPTOR TYPE TYROSINE PHOSPHATASE J, PTPRJ, GLYCOPROTEIN, PROTEIN PHOSPHATASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, HYDROLASE
4ohd:A (ASN306) to (GLY483) LEOPARD SYNDROME-ASSOCIATED SHP2/A461T MUTANT | SH2 DOMAIN, PHOSPHATASE DOMAIN, HYDROLASE
4ohi:A (ASN306) to (GLY483) LEOPARD SYNDROME-ASSOCIATED SHP2/Q510E MUTANT | SH2 DOMAIN, PHOSPHATASE DOMAIN, HYDROLASE
4ohl:A (ASN306) to (GLU481) LEOPARD SYNDROME-ASSOCIATED SHP2/T468M MUTANT | SH2 DOMAIN, PHOSPHATASE DOMAIN, HYDROLASE
1lqf:B (ASN568) to (LYS737) STRUCTURE OF PTP1B IN COMPLEX WITH A PEPTIDIC BISPHOSPHONATE INHIBITOR | PHOSPHATASE, PHOSPHONATES, DIABETES, INHIBITOR, HYDROLASE
2zmm:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PTP1B-INHIBITOR COMPLEX | PTP1B, PROTEIN-INHIBITOR COMPLEX, ACETYLATION, ENDOPLASMIC RETICULUM, HYDROLASE, MEMBRANE, OXIDATION, PHOSPHOPROTEIN, POLYMORPHISM, PROTEIN PHOSPHATASE
2zn7:A (ASN68) to (ARG238) CRYSTAL STRUCTURES OF PTP1B-INHIBITOR COMPLEXES | PTP1B, PROTEIN-INHIBITOR COMPLEX, ACETYLATION, ENDOPLASMIC RETICULUM, HYDROLASE, MEMBRANE, OXIDATION, PHOSPHOPROTEIN, POLYMORPHISM, PROTEIN PHOSPHATASE
1ygr:A (ASN994) to (THR1166) CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAIN OF RPTP CD45 | PROTEIN TYROSINE PHOSPHATASE, RPTP, CD45, LCA, LYMPHOCYTE ACTIVATION, CD3 ZETA, ITAM, HYDROLASE
1ygr:B (ASN994) to (THR1166) CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAIN OF RPTP CD45 | PROTEIN TYROSINE PHOSPHATASE, RPTP, CD45, LCA, LYMPHOCYTE ACTIVATION, CD3 ZETA, ITAM, HYDROLASE
1ygu:A (ASN994) to (GLU1168) CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP CD45 WITH A PTYR PEPTIDE | CD45, PROTEIN TYROSINE PHOSPHATASE, PHOSPHOTYROSINE, POLYOMA MIDDLE T ANTIGEN, RPTP, HYDROLASE
1ygu:B (ASN994) to (GLU1168) CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP CD45 WITH A PTYR PEPTIDE | CD45, PROTEIN TYROSINE PHOSPHATASE, PHOSPHOTYROSINE, POLYOMA MIDDLE T ANTIGEN, RPTP, HYDROLASE
4pvg:A (ASN306) to (GLY483) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE SHP2 CATALYTIC DOMAIN COMPLEX WITH SMALL MOLECULAR COMPOUND L88N79 | HYDROLASE
1zc0:A (ASN130) to (GLY294) CRYSTAL STRUCTURE OF HUMAN HEMATOPOIETIC TYROSINE PHOSPHATASE (HEPTP) CATALYTIC DOMAIN | HEPTP, HUMAN TYROSINE PHOSPHATASE CATALYTIC DOMAIN, LC-PTP, PTPN7, HYDROLASE
2a8b:A (ASN448) to (GLU610) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE PHOSPHATASE RECEPTOR, TYPE R | PROTEIN TYROSINE PHOSPHATASE, RECEPTOR, HUMAN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, HYDROLASE
3b7o:A (ASN306) to (GLU481) CRYSTAL STRUCTURE OF THE HUMAN TYROSINE PHOSPHATASE SHP2 (PTPN11) WITH AN ACCESSIBLE ACTIVE SITE | SHP2, PTPN11, TYROSINE PHOSPHATASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, DEAFNESS, DISEASE MUTATION, HYDROLASE, PHOSPHORYLATION, PROTEIN PHOSPHATASE, SH2 DOMAIN
3mow:A (ASN306) to (GLY483) CRYSTAL STRUCTURE OF SHP2 IN COMPLEX WITH A TAUTOMYCETIN ANALOG TTN D- 1 | NATURAL PRODUCT, CATALYTIC DOMAIN, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4bpc:A (ASN1737) to (TYR1902) STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE SIGMA IN THE SULFENIC ACID FORM | HYDROLASE, PROTEOGLYCAN, REDOX REGULATION
4rdd:A (ASN306) to (GLY483) CO-CRYSTAL STRUCTURE OF SHP2 IN COMPLEX WITH A CEFSULODIN DERIVATIVE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o5x:A (ASN306) to (GLY483) CRYSTAL STRUCTURE OF THE ONCOGENIC TYROSINE PHOSPHATASE SHP2 COMPLEXED WITH A SALICYLIC ACID-BASED SMALL MOLECULE INHIBITOR | SHP2-IIB-08 COMPLEX, INHIBITOR, BINDING AFFINITY, BINDING SELECTIVITY, RECEPTOR, HYDROLASE, DEPHOSPHORYLATION
5i6v:B (ASN306) to (GLY483) STRUCTURE OF F285S, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | SHP2, CANCER-ASSOCIATED MUTATION, INHIBITORS, HYDROLASE
5ibm:A (ASN306) to (GLY483) STRUCTURE OF S502P, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2 S502P, TYROSINE-PROTEIN PHOSPHATASE NON- RECEPTOR TYPE 11, HYDROLASE
5ibm:B (ASN306) to (GLY483) STRUCTURE OF S502P, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2 S502P, TYROSINE-PROTEIN PHOSPHATASE NON- RECEPTOR TYPE 11, HYDROLASE
5ibs:A (ASN306) to (GLY483) STRUCTURE OF E76Q, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11, HYDROLASE
5ibs:B (ASN306) to (GLY483) STRUCTURE OF E76Q, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11, HYDROLASE
3qcc:B (ASN910) to (ASP1082) HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE GAMMA, DOMAIN 1, IN COMPLEX WITH VANADATE, ORTHORHOMBIC CRYSTAL FORM | TYROSINE RECEPTOR PHOSPHATASE, TWISTED MIXED BETA-SHEETS FLANKED BY {ALPHA}-HELICES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qcd:A (ASN910) to (ASP1082) HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE GAMMA, DOMAIN 1, IN COMPLEX WITH VANADATE, TRIGONAL CRYSTAL FORM | TYROSINE RECEPTOR PHOSPHATASE, TWISTED MIXED BETA-SHEETS FLANKED BY {ALPHA}-HELICES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qcl:A (ASN910) to (ASP1082) HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE GAMMA, DOMAIN 1, IN COMPLEX WITH 2-[(3,4-DICHLOROBENZYL)SULFANYL]-4-(4-HYDROXYBUT-1-YN-1- YL)BENZOIC ACID | TYROSINE RECEPTOR PHOSPHATASE, TWISTED MIXED BETA-SHEETS FLANKED BY {ALPHA}-HELICES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qkp:A (ASN68) to (LYS237) PROTEIN TYROSINE PHOSPHATASE 1B - APO W179F MUTANT WITH OPEN WPD-LOOP | HYDROLASE, P-LOOP, WPD-LOOP, PROTEIN PHOSPHATASE, EGFR RECEPTOR, PHOSPHOPROTEIN
4ge2:B (ASN359) to (GLU537) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9 (MEG2) COMPLEX WITH COMPOUND 3 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ge5:A (ASN359) to (GLU537) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9 (MEG2) COMPLEX WITH COMPOUND 5 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ge6:A (ASN359) to (GLU537) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9 (MEG2) COMPLEX WITH COMPOUND 7 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ge6:B (ASN359) to (GLU537) CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9 (MEG2) COMPLEX WITH COMPOUND 7 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ooq:B (ASN966) to (ASN1128) CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRT | PROTEIN TYROSINE PHOSPHATASE, RECEPTOR, HUMAN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, HYDROLASE
2bgd:A (ASN68) to (ARG238) STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS | PROTEIN TYROSINE PHOSPHATASE, 1, 2, 5-THIADIAZOLIDIN-3-ONE-1, 1-DIOXIDE TEMPLATE, HYDROLASE
2bge:A (ASN68) to (ARG238) STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS | PROTEIN TYROSINE PHOSPHATASE, 1, 2, 5-THIADIAZOLIDIN-3-ONE-1, 1-DIOXIDE TEMPLATE, HYDROLASE
1c85:A (ASN68) to (LYS239) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID | HYDROLASE, PHOSPHORYLATION, LIGAND, INHIBITOR
2qbp:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PTP1B-INHIBITOR COMPLEX | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2qbq:A (ASN68) to (ARG238) CRYSTAL STRUCTURE OF PTP1B-INHIBITOR COMPLEX | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2cjz:A (ASN331) to (GLN494) CRYSTAL STRUCTURE OF THE C472S MUTANT OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED PHOSPHATASE) IN COMPLEX WITH PHOSPHOTYROSINE | PROTEIN PHOSPHATASE, STEP, PTPN5, HYDROLASE, PHOSPHATASE
2cma:A (ASN68) to (LYS237) STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS | POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE
2cni:A (ASN68) to (LYS237) STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE
1ptt:A (ASN68) to (LYS237) CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE (AC-DEPYL-NH2) | HYDROLASE, ACETYLATION, PHOSPHORYLATION, PEPTIDE, COMPLEX (HYDROLASE/PEPTIDE) COMPLEX
2hvl:A (ASN130) to (GLY294) CRYSTAL STRUCTURE OF THE HEPTP CATALYTIC DOMAIN C270S MUTANT | HEPTP, HUMAN TYROSINE PHOSPHATASE CATALYTIC DOMAIN, LC-PTP, PTPN7, SUBSTRATE-TRAPPING MUTANT, HYDROLASE
1jf7:A (ASN68) to (LYS237) HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836 | HYDROLASE (PHOSPHORYLATION), TYROSINE PHOSPHATASE, INHIBITOR, COMPLEX
3zm0:A (ASN306) to (GLU481) CATALYTIC DOMAIN OF HUMAN SHP2 | HYDROLASE, PTP1B
1l8g:A (ASN68) to (LYS239) CRYSTAL STRUCTURE OF PTP1B COMPLEXED WITH 7-(1,1-DIOXO-1H- BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7- DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | PROTEIN-INHIBITOR, HYDROLASE
5ehr:A (ASN306) to (GLY483) NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099 | PHOSPHATASE PTP INHIBITOR PTPN11 ALLOSTERIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5ehr:B (ASN306) to (GLY483) NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099 | PHOSPHATASE PTP INHIBITOR PTPN11 ALLOSTERIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3cwe:A (ASN568) to (LYS737) PTP1B IN COMPLEX WITH A PHOSPHONIC ACID INHIBITOR | PHOSPHATASE, PHOSPHONATES, DIABETES, INHIBITOR, ACETYLATION, ENDOPLASMIC RETICULUM, HYDROLASE, MEMBRANE, OXIDATION, PHOSPHOPROTEIN, POLYMORPHISM, PROTEIN PHOSPHATASE
3qch:A (ASN910) to (ASP1082) HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE GAMMA, DOMAIN 1, IN COMPLEX WITH 3-[(3,4-DICHLOROBENZYL)SULFANYL]-N-(METHYLSULFONYL) THIOPHENE-2-CARBOXAMIDE | TYROSINE RECEPTOR PHOSPHATASE, TWISTED MIXED BETA-SHEETS FLANKED BY {ALPHA}-HELICES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX