3rlq:A (HIS77) to (LEU188) CO-CRYSTAL STRUCTURE OF THE HSP90 ATP BINDING DOMAIN IN COMPLEX WITH 4-(2,4-DICHLORO-5-METHOXYPHENYL)-2-METHYL-7H-PYRROLO[2,3- D]PYRIMIDINE-5- CARBONITRILE | CHAPERONE
3rlr:A (HIS77) to (LEU188) CO-CRYSTAL STRUCTURE OF THE HSP90 ATP BINDING DOMAIN IN COMPLEX WITH 4-(2,4-DICHLORO-5-METHOXYPHENYL)-2,6-DIMETHYL-7H-PYRROLO[2,3- D]PYRIMIDINE-5-CARBONITRILE | CHAPERONE
3eko:A (HIS77) to (LEU188) DIHYDROXYLPHENYL AMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE | HSP90 INHIBITORS, ALTERNATIVE SPLICING, ATP-BINDING, CHAPERONE, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
3ekr:A (HIS77) to (LEU188) DIHYDROXYLPHENYL AMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE | HSP90 INHIBITORS, ALTERNATIVE SPLICING, ATP-BINDING, CHAPERONE, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
2bre:A (PHE63) to (LEU175) STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. | CHAPERONE/COMPLEX, 3D-STRUCTURE, ATP-BINDING, CHAPERONE, HEAT SHOCK, INHIBITOR, MULTIGENE FAMILY
2bre:B (PHE63) to (LEU175) STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. | CHAPERONE/COMPLEX, 3D-STRUCTURE, ATP-BINDING, CHAPERONE, HEAT SHOCK, INHIBITOR, MULTIGENE FAMILY
2bt0:A (HIS77) to (LEU188) NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN | ATP-BINDING, CHAPERONE, HEAT SHOCK, PHOSPHORYLATION
2bt0:B (HIS77) to (LEU188) NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN | ATP-BINDING, CHAPERONE, HEAT SHOCK, PHOSPHORYLATION
4xc0:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN COMPLEX WITH ACP | HSP90, ACP, CHAPERONE
1byq:A (HIS77) to (LEU188) HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG | CHAPERONE PROTEIN, ATP BINDING
4xcl:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN COMPLEX WITH AGS | HSP90, AGS, CHAPERONE
4xd8:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN COMPLEX WITH ANP | HSP90, ANP, CHAPERONE
2byh:A (HIS77) to (LEU188) 3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE | PYRAZOLE, HSP90, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION
2byi:A (HIS77) to (LEU188) 3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE | PYRAZOLE, HSP90, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION
4xe2:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN COMPLEX WITH PEPTIDE | HSP90, ACP, CHAPERONE
2bz5:B (HIS77) to (LEU188) STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS | ATP-BINDING, CHAPERONE, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION
4xka:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN HEXAGONAL FORM WITH GLYCEROL | HSP90, CHAPERONE, GLYCEROL
4xkk:A (GLU66) to (ARG172) CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM | HSP90, CHAPERONE, DICTYOSTELIUM DISCOIDEUM
4xko:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN HEXAGONAL FORM WITH PEG | HSP90, CHAPERONE, PEG
1osf:A (HIS77) to (LEU188) HUMAN HSP90 IN COMPLEX WITH 17-DESMETHOXY-17-N,N- DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN | CELL CYCLE
3ft5:A (HIS77) to (LEU188) STRUCTURE OF HSP90 BOUND WITH A NOVEL FRAGMENT | HSP90 N-TERMINAL NUCLEOTIDE BINDING DOMAIN, ALTERNATIVE SPLICING, ATP-BINDING, CHAPERONE, CYTOPLASM, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
2ccs:A (HIS77) to (LEU188) HUMAN HSP90 WITH 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-3- YL)-BENZENE-1,2-DIOL | HEAT-SHOCK PROTEIN/COMPLEX, HSP90, ATPASE, PYRAZOLE, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION
2ccu:A (HIS77) to (LEU188) HUMAN HSP90 WITH 4-CHLORO-6-(4-(4-(4-METHANESULPHONYL- BENZYL)-PIERAZIN-1-YL)-1H-PYRAZOL-3-YL)-BENZENE-1,3-DIOL | HEAT-SHOCK PROTEIN/COMPLEX, HSP90, ATPASE, PYRAZOLE, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION
2cg9:B (PHE63) to (PHE176) CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX | CHAPERONE, CHAPERONE COMPLEX, HSP90, HEAT SHOCK PROTEIN, CO-CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, ACETYLATION
2cgf:A (ILE64) to (ARG169) A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N- TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE | ATP-BINDING, CHAPERONE, HEAT SHOCK, INHIBITOR, MULTIGENE FAMILY
2qfo:A (HIS77) to (LEU188) HSP90 COMPLEXED WITH A143571 AND A516383 | PROTEIN-INHIBITOR COMPLEX, ATP-BINDING, CHAPERONE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
2qfo:B (HIS77) to (LEU188) HSP90 COMPLEXED WITH A143571 AND A516383 | PROTEIN-INHIBITOR COMPLEX, ATP-BINDING, CHAPERONE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
2qg0:A (HIS77) to (LEU188) HSP90 COMPLEXED WITH A943037 | PROTEIN-INHIBITOR COMPLEX, CHAPERONE
2qg0:B (HIS77) to (LEU188) HSP90 COMPLEXED WITH A943037 | PROTEIN-INHIBITOR COMPLEX, CHAPERONE
3t0h:A (HIS77) to (ARG182) STRUCTURE INSIGHTS INTO MECHANISMS OF ATP HYDROLYSIS AND THE ACTIVATION OF HUMAN HSP90 | CHAPERONE, ATPASE
3t0z:A (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN BOUND TO ATP | CHAPERONE, ATPASE
3t10:A (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN BOUND TO ACP | CHAPERONE, ATPASE
3t1k:A (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN BOUND TO ANP | CHAPERONE, ATPASE
3t1k:B (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN BOUND TO ANP | CHAPERONE, ATPASE
4ipe:A (ILE158) to (HIS271) CRYSTAL STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) WITH AMPPNP | CHAPERONE, ATPASE, ATP BINDING, MITOCHONDRIA
3t2s:A (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN BOUND TO AGS | CHAPERONE, ATPASE
3t2s:B (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN BOUND TO AGS | CHAPERONE, ATPASE
4ivg:A (THR153) to (LEU270) CRYSTAL STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) NTD-MIDDLE DOMAIN DIMER WITH AMPPNP | CHAPERONE, ATPASE, ATP BINDING, MITOCHONDRIA
4iyn:A (THR153) to (HIS271) STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) WITH ADP-ALF4- | CHAPERONE, ATP BINDING, ATPASE, MITOCHONDRIA
4jql:A (HIS77) to (ARG182) SYNTHESIS OF BENZOQUINONE-ANSAMYCIN-INSPIRED MACROCYCLIC LACTAMS FROM SHIKIMIC ACID | INHIBITOR DESIGN, HSP90, NUCLEOTIDE BINDING DOMAIN, CHAPERONE, GELDANAMYCIN, CYTOSOLE, CHAPERONE-INHIBITOR COMPLEX
4ykr:A (HIS77) to (LEU188) HEAT SHOCK PROTEIN 90 BOUND TO CS302 | CHAPERONE, PROTEIN-INHIBITOR COMPLEX, HSP 90, CHAPERONE-INHIBITOR COMPLEX
4ykq:A (HIS77) to (ARG182) HEAT SHOCK PROTEIN 90 BOUND TO CS301 | CHAPERONE, HSP 90, PROTEIN-INHIBITOR COMPLEX, CHAPERONE-INHIBITOR COMPLEX
4yku:A (HIS77) to (LEU188) HEAT SHOCK PROTEIN 90 BOUND TO CS311 | CHAPERONE, PROTEIN-INHIBITOR COMPLEX, HSP 90, CHAPERONE-INHIBITOR COMPLEX
4ykx:A (HIS77) to (LEU188) HEAT SHOCK PROTEIN 90 BOUND TO CS318 | CHAPERONE, PROTEIN-INHIBITOR COMPLEX, HSP 90, CHAPERONE-INHIBITOR COMPLEX
4yky:A (HIS77) to (LEU188) HEAT SHOCK PROTEIN 90 BOUND TO CS319 | CHAPERONE, PROTEIN-INHIBITOR COMPLEX, HSP 90, CHAPERONE-INHIBITOR COMPLEX
4ykz:A (HIS77) to (LEU188) HEAT SHOCK PROTEIN 90 BOUND TO CS320 | CHAPERONE, PROTEIN-INHIBITOR COMPLEX, HSP 90, CHAPERONE-INHIBITOR COMPLEX
1qy5:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH THE SPECIFIC LIGAND NECA | GRP94, NECA, HSP90, CHAPERONE
1qy8:A (VAL134) to (LEU249) CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH RADICICOL | GRP94, GP96, HSP90, RADICICOL, CHAPERONE
1qye:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH 2-CHLORODIDEOXYADENOSINE | GRP94, GP96, HSP90, 2CLDDA, 2-CHLORODIDEOXYADENOSINE, CHAPERONE
2uwd:A (HIS77) to (LEU188) INHIBITION OF THE HSP90 MOLECULAR CHAPERONE IN VITRO AND IN VIVO BY NOVEL, SYNTHETIC, POTENT RESORCINYLIC PYRAZOLE, ISOXAZOLE AMIDE ANALOGS | CHAPERONE, HEAT SHOCK, ATP-BINDING, PHOSPHORYLATION, NUCLEOTIDE-BINDING
3hhu:A (HIS77) to (LEU188) HUMAN HEAT-SHOCK PROTEIN 90 (HSP90) IN COMPLEX WITH {4-[3- (2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-5-THIOXO- 1,5-DIHYDRO- [1,2,4]TRIAZOL-4-YL]-BENZYL}-CARBAMIC ACID ETHYL ESTER {ZK 2819} | HSP90, ATPASE, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION, ALTERNATIVE SPLICING, CYTOPLASM, PHOSPHOPROTEIN, STRESS RESPONSE
3hhu:B (HIS77) to (LEU188) HUMAN HEAT-SHOCK PROTEIN 90 (HSP90) IN COMPLEX WITH {4-[3- (2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-5-THIOXO- 1,5-DIHYDRO- [1,2,4]TRIAZOL-4-YL]-BENZYL}-CARBAMIC ACID ETHYL ESTER {ZK 2819} | HSP90, ATPASE, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION, ALTERNATIVE SPLICING, CYTOPLASM, PHOSPHOPROTEIN, STRESS RESPONSE
2esa:A (THR133) to (LEU249) GRP94 N-TERMINAL DOMAIN BOUND TO GELDANAMYCIN: EFFECTS OF MUTANTS 168- 169 KS-AA | GRP94 GP96 HSP90 BERGERAT CHAPERONE ENDOPLASMIC RETICULUM GELDANAMYCIN 17-AAG, CHAPERONE
2vci:A (HIS77) to (LEU188) 4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER | ALTERNATIVE SPLICING, ATP-BINDING, PHOSPHORYLATION, CYTOPLASM, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING
2vcj:A (HIS77) to (LEU188) 4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER | ALTERNATIVE SPLICING, ATP-BINDING, PHOSPHORYLATION, CYTOPLASM, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING
2fxs:A (PHE63) to (ARG169) YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADAMIDE | HSP82, HSP90, GRP94, HTPG, CHAPERONE, LIGAND, RADICICOL, GELDANAMYCIN, RADESTER
2fyp:A (THR133) to (LEU249) GRP94 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADESTER AMINE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, RADICICOL, GELDANAMYCIN, RADESTER, RADAMIDE
2fyp:B (THR133) to (LEU249) GRP94 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADESTER AMINE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, RADICICOL, GELDANAMYCIN, RADESTER, RADAMIDE
2vw5:A (PRO60) to (LEU175) STRUCTURE OF THE HSP90 INHIBITOR 7-O-CARBAMOYLPREMACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90 | ATPASE, CYTOPLASM, INHIBITOR, CHAPERONE, ATP-BINDING, STRESS RESPONSE, NUCLEOTIDE-BINDING
2vw5:B (ILE64) to (LEU175) STRUCTURE OF THE HSP90 INHIBITOR 7-O-CARBAMOYLPREMACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90 | ATPASE, CYTOPLASM, INHIBITOR, CHAPERONE, ATP-BINDING, STRESS RESPONSE, NUCLEOTIDE-BINDING
2vw5:C (PRO60) to (LEU175) STRUCTURE OF THE HSP90 INHIBITOR 7-O-CARBAMOYLPREMACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90 | ATPASE, CYTOPLASM, INHIBITOR, CHAPERONE, ATP-BINDING, STRESS RESPONSE, NUCLEOTIDE-BINDING
2vw5:D (PRO60) to (LEU175) STRUCTURE OF THE HSP90 INHIBITOR 7-O-CARBAMOYLPREMACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90 | ATPASE, CYTOPLASM, INHIBITOR, CHAPERONE, ATP-BINDING, STRESS RESPONSE, NUCLEOTIDE-BINDING
2vwc:A (ILE64) to (LEU175) STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90. | CHAPERONE, CHAPERONE/COMPLEX, CHAPERONE-COMPLEX, INHIBITOR, HEAT SHOCK, ATP-BINDING, STRESS RESPONSE, MULTIGENE FAMILY, NUCLEOTIDE-BINDING
2gfd:A (THR133) to (LEU249) GRP94 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADAMIDE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, RADICICOL, GELDANAMYCIN, RADESTER, RADAMIDE
2gfd:B (THR133) to (LEU249) GRP94 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADAMIDE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, RADICICOL, GELDANAMYCIN, RADESTER, RADAMIDE
3vha:A (HIS77) to (ARG182) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A MACROCYCLIC INHIBITOR | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3vhc:A (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A MACROCYCLIC INHIBITOR | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
4l93:A (HIS77) to (ARG182) CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S36 | ATP HYDROLYSIS, HSP90N-HSP90N INHIBITOR COMPLEX, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
4l93:B (HIS77) to (LEU188) CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S36 | ATP HYDROLYSIS, HSP90N-HSP90N INHIBITOR COMPLEX, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
4l94:A (HIS77) to (ARG182) CRYSTAL STRUCTURE OF HUMAN HSP90 WITH S46 | ATP HYDROLYSIS, HSP90N-HSP90N INHIBITOR COMPLEX, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
1tc0:A (THR133) to (LEU249) LIGAND INDUCED CONFORMATIONAL SHIFTS IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION COMPLEXED WITH THE PHYSIOLOGICAL PARTNER ATP | GRP94, HSP90, ATP, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM
1tc6:A (THR133) to (LEU249) LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION ADP-COMPLEX | GRP94, HSP90, ADP, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM
2h8m:A (THR133) to (LEU249) N-DOMAIN OF GRP94 IN COMPLEX WITH THE 2-IODO-NECA | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, NECA, NPCA, ADENOSINE
2h8m:B (THR133) to (LEU249) N-DOMAIN OF GRP94 IN COMPLEX WITH THE 2-IODO-NECA | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, NECA, NPCA, ADENOSINE
2hch:A (THR133) to (LEU249) N-DOMAIN OF GRP94 IN COMPLEX WITH THE NOVEL LIGAND N-(2- AMINO)ETHYL CARBOXYAMIDO ADENOSINE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, NECA, NPCA, NEACA, NEOCA, ADENOSINE
2hch:B (THR133) to (LEU249) N-DOMAIN OF GRP94 IN COMPLEX WITH THE NOVEL LIGAND N-(2- AMINO)ETHYL CARBOXYAMIDO ADENOSINE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, NECA, NPCA, NEACA, NEOCA, ADENOSINE
2weq:A (PHE63) to (LEU175) YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH GELDANAMYCIN | ATPASE, CYTOPLASM, CHAPERONE, ATP-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE, NUCLEOTIDE-BINDING
2wep:A (ILE64) to (ARG169) YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH ADP | ATPASE, CHAPERONE, ATP-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE, NUCLEOTIDE-BINDING
2wer:A (ILE64) to (ARG169) YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH RADICICOL | ATPASE, CHAPERONE, ATP-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE, NUCLEOTIDE-BINDING
2wer:B (ILE64) to (LEU175) YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH RADICICOL | ATPASE, CHAPERONE, ATP-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE, NUCLEOTIDE-BINDING
2hg1:A (THR133) to (LEU249) N-DOMAIN OF GRP94 IN COMPLEX WITH THE NOVEL LIGAND N-(2- HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, NECA, NPCA, NEACA, NEOCA, ADENOSINE
2hg1:B (THR133) to (LEU249) N-DOMAIN OF GRP94 IN COMPLEX WITH THE NOVEL LIGAND N-(2- HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, NECA, NPCA, NEACA, NEOCA, ADENOSINE
2wi1:A (HIS77) to (LEU188) ORALLY ACTIVE 2-AMINO THIENOPYRIMIDINE INHIBITORS OF THE HSP90 CHAPERONE | PU3, HSP90, ATPASE, CHAPERONE, HEAT SHOCK, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2wi2:A (HIS77) to (LEU188) ORALLY ACTIVE 2-AMINO THIENOPYRIMIDINE INHIBITORS OF THE HSP90 CHAPERONE | PU3, HSP90, ATPASE, CHAPERONE, HEAT SHOCK, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2wi2:B (HIS77) to (LEU188) ORALLY ACTIVE 2-AMINO THIENOPYRIMIDINE INHIBITORS OF THE HSP90 CHAPERONE | PU3, HSP90, ATPASE, CHAPERONE, HEAT SHOCK, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2wi3:A (HIS77) to (ARG182) ORALLY ACTIVE 2-AMINO THIENOPYRIMIDINE INHIBITORS OF THE HSP90 CHAPERONE | CHAPERONE, HEAT SHOCK, STRESS RESPONSE, NUCLEOTIDE-BINDING
2wi5:A (HIS77) to (LEU188) ORALLY ACTIVE 2-AMINO THIENOPYRIMIDINE INHIBITORS OF THE HSP90 CHAPERONE | PU3, HSP90, ATPASE, CHAPERONE, HEAT SHOCK, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
1u0y:A (THR133) to (LEU249) N-DOMAIN OF GRP94, WITH THE CHARGED DOMAIN, IN COMPLEX WITH THE NOVEL LIGAND N-PROPYL CARBOXYAMIDO ADENOSINE | GRP94, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, NECA, ADENOSINE, NPCA
1u0z:A (THR133) to (LEU249) N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH RADICICOL | GRP94, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, RADICICOL
1u2o:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH NECA | GRP94, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, NECA
1u2o:B (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH NECA | GRP94, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, NECA
4lwi:A (HIS77) to (ARG182) CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ6 | ROSSMANN FOLD, ATP BINDING, MOLECULARCHAPERONE, CHAPERONE
1us7:A (PHE63) to (ARG169) COMPLEX OF HSP90 AND P50 | CHAPERONE CO-CHAPERONE REGULATION, CHAPERONE, ATP-BINDING, HEAT SHOCK,
2iop:D (GLY61) to (GLU182) CRYSTAL STRUCTURE OF FULL-LENGTH HTPG, THE ESCHERICHIA COLI HSP90, BOUND TO ADP | HEAT SHOCK PROTEIN, CHAPERONE, HSP90
2ior:A (ARG64) to (GLU182) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HTPG, THE ESCHERICHIA COLI HSP90, BOUND TO ADP | HEAT SHOCK PROTEIN, CHAPERONE, HSP90
2xab:A (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH AN INHIBITOR BOUND | CANCER, CHAPERONE, ATP-BINDING, NUCLEOTIDE-BINDING, STRESS RESPONSE
2xab:B (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH AN INHIBITOR BOUND | CANCER, CHAPERONE, ATP-BINDING, NUCLEOTIDE-BINDING, STRESS RESPONSE
2iws:A (ILE64) to (LEU175) RADICICOL ANALOGUES BOUND TO THE ATP SITE OF HSP90 | INHIBITOR, CHAPERONE, HEAT SHOCK, ATP-BINDING, MULTIGENE FAMILY, NUCLEOTIDE-BINDING
2iwu:A (ARG65) to (ARG169) ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90 | INHIBITOR, CHAPERONE, HEAT SHOCK, ATP-BINDING, MULTIGENE FAMILY, NUCLEOTIDE-BINDING
2iwx:A (PHE63) to (LEU175) ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90. | INHIBITOR, CHAPERONE, HEAT SHOCK, ATP-BINDING, MULTIGENE FAMILY, CHAPERONE-COMPLEX, CHAPERONE/COMPLEX, NUCLEOTIDE- BINDING
2xcm:A (PHE65) to (ARG171) COMPLEX OF HSP90 N-TERMINAL, SGT1 CS AND RAR1 CHORD2 DOMAIN | CHAPERONE-PROTEIN BINDING COMPLEX, STRESS RESPONSE
2xd6:A (ILE64) to (LEU175) HSP90 COMPLEXED WITH A RESORCYLIC ACID MACROLACTONE. | CHAPERONE, INHIBITOR, ATPASE
2xdk:A (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE
2xdl:A (HIS77) to (ARG182) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE
2xdx:A (HIS77) to (LEU188) STRUCTRE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE, INHIBITOR, STRESS RESPONSE
2xhr:A (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE, ATP BINDING DOMAIN, N-TERMINAL DOMAIN, STRESS RESPONSE
2xjx:A (HIS77) to (ARG182) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE, ATP BINDING DOMAIN, STRESS RESPONSE
2xk2:A (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE, STRESS RESPONSE
2jjc:A (HIS77) to (ARG182) HSP90 ALPHA ATPASE DOMAIN WITH BOUND SMALL MOLECULE FRAGMENT | HSP90, ATPASE, CHAPERONE, CYTOPLASM, HEAT SHOCK, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, ATP-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
2xx2:A (PRO60) to (LEU175) MACROLACTONE INHIBITOR BOUND TO HSP90 N-TERM | CHAPERONE
2xx2:B (ILE64) to (LEU175) MACROLACTONE INHIBITOR BOUND TO HSP90 N-TERM | CHAPERONE
2xx2:D (PRO60) to (LEU175) MACROLACTONE INHIBITOR BOUND TO HSP90 N-TERM | CHAPERONE
2xx4:A (ILE64) to (LEU175) MACROLACTONE INHIBITOR BOUND TO HSP90 N-TERM | CHAPERONE
4nh9:A (THR133) to (LEU249) CORRELATION BETWEEN CHEMOTYPE-DEPENDENT BINDING CONFORMATIONS OF HSP90 ALPHA/BETA AND ISOFORM SELECTIVITY | A/B STRUCTURE, CHAPERONE, ENDOPLASMIC RETICULUM
2ye2:A (HIS77) to (ARG182) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2ye4:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2ye5:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2ye6:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yea:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yec:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yeb:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yed:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yef:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yeg:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING
2yeh:A (HIS77) to (LEU188) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | CHAPERONE, STRESS RESPONSE
2yga:A (PHE63) to (LEU175) E88G-N92L MUTANT OF N-TERM HSP90 COMPLEXED WITH GELDANAMYCIN | CHAPERONE
2ygf:A (PRO60) to (ARG169) L89V, L93I AND V136M MUTANT OF N-TERM HSP90 COMPLEXED WITH GELDANAMYCIN | CHAPERONE
2yge:A (PHE63) to (LEU175) E88G-N92L MUTANT OF N-TERM HSP90 COMPLEXED WITH GELDANAMYCIN | CHAPERONE
2yi6:A (HIS77) to (LEU188) STRUCTURAL CHARACTERIZATION OF 5-ARYL-4-(5-SUBSTITUTED-2- 4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLE HSP90 INHIBITORS. | CHAPERONE, ATPASE
2yi7:A (HIS77) to (LEU188) STRUCTURAL CHARACTERIZATION OF 5-ARYL-4-(5-SUBSTITUTED-2-4- DIHYDROXYPHENYL)-1,2,3-THIADIAZOLE HSP90 INHIBITORS. | CHAPERONE, ATPASE
2o1w:B (THR133) to (LEU249) STRUCTURE OF N-TERMINAL PLUS MIDDLE DOMAINS (N+M) OF GRP94 | GRP94, HSP82, HSP90, HTPG, CHAPERONE, GP96, ENDOPLASMIN,
3k60:A (PRO60) to (ARG169) CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PLASMODIUM FALCIPARUM HSP90 (PF07_0029) BOUND TO ADP | CHAPERONE, ATPASE, STRESS RESPONSE
3k97:A (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN IN COMPLEX WITH 4-CHLORO-6-{[(2R)-2- (2-METHYLPHENYL)PYRROLIDIN-1-YL]CARBONYL}BENZENE-1,3-DIOL | HSP90, ATP BINDING DOMAIN, N-TERMINAL DOMAIN, INHIBITION, ACETYLATION, ALTERNATIVE SPLICING, ATP-BINDING, CHAPERONE, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
3k98:A (HIS77) to (ARG182) HSP90 N-TERMINAL DOMAIN IN COMPLEX WITH (1R)-2-(5-CHLORO-2, 4-DIHYDROXYBENZOYL)-N-ETHYLISOINDOLINE-1-CARBOXAMIDE | HSP90, ATP BINDING DOMAIN, INHIBITION, ACETYLATION, ALTERNATIVE SPLICING, ATP-BINDING, CHAPERONE, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
3k99:B (HIS77) to (LEU188) HSP90 N-TERMINAL DOMAIN IN COMPLEX WITH 4-(1,3-DIHYDRO-2H- ISOINDOL-2-YLCARBONYL)BENZENE-1,3-DIOL | HSP90, N-TERMINAL DOMAIN, ATP BINDING DOMAIN, INHIBITION, ACETYLATION, ALTERNATIVE SPLICING, ATP-BINDING, CHAPERONE, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
1yc3:A (HIS77) to (ARG182) CRYSTAL STRUCTURE OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES | CELL-CYCLE, CANCER, DRUG DESIGN, CELL CYCLE
1yc4:A (HIS77) to (ARG182) CRYSTAL STRUCTURE OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES | CELL-CYCLE, CANCER, DRUG DESIGN, CELL CYCLE
1yes:A (HIS77) to (ARG182) HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION | CHAPERONE PROTEIN, GELDANAMYCIN, SIGNAL TRANSDUCTION, HEAT SHOCK
1yer:A (HIS77) to (LEU188) HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "CLOSED" CONFORMATION | CHAPERONE PROTEIN, GELDANAMYCIN, SIGNAL TRANSDUCTION, HEAT SHOCK
1yet:A (HIS77) to (ARG182) GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN | CHAPERONE PROTEIN, GELDANAMYCIN, SIGNAL TRANSDUCTION, HEAT SHOCK
1ysz:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA | GRP94, GP96, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, NECA, HTPG
1yt1:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL | GRP94, GP96, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, HTPG
1yt1:B (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL | GRP94, GP96, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, HTPG
4asa:A (PHE63) to (ARG169) THE STRUCTURE OF MODIFIED BENZOQUINONE ANSAMYCINS BOUND TO YEAST N-TERMINAL HSP90 | CHAPERONE, INHIBITION, ANSAMYCIN
4asg:A (PHE63) to (LEU175) THE STRUCTURE OF MODIFIED BENZOQUINONE ANSAMYCINS BOUND TO YEAST N-TERMINAL HSP90 | CHAPERONE, INHIBITIOR, ANSAMYCIN
4asf:A (PHE63) to (ARG169) THE STRUCTURE OF MODIFIED BENZOQUINONE ANSAMYCINS BOUND TO YEAST N-TERMINAL HSP90 | INHIBITION, ANSAMYCIN, CHAPERONE
1zwh:A (PHE63) to (LEU175) YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADESTER AMINE | HSP82, HSP90, GRP94, HTPG, CHAPERONE, LIGAND, RADICICOL, GELDANAMYCIN
4b7p:A (HIS77) to (ARG182) STRUCTURE OF HSP90 WITH NMS-E973 INHIBITOR BOUND | ATPASE, CHAPERONE, ATP-BINDING
3b24:A (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZINE FRAGMENT MOLECULE | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3b24:B (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN AMINOTRIAZINE FRAGMENT MOLECULE | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3b26:A (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR RO1127850 | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3b26:B (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR RO1127850 | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3b28:A (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR CH5015765 | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3b28:B (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR CH5015765 | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3bm9:A (HIS77) to (ARG182) DISCOVERY OF BENZISOXAZOLES AS POTENT INHIBITORS OF CHAPERONE HSP90 | CHAPERONE, ATP BINDING DOMAIN, ALTERNATIVE SPLICING, ATP- BINDING, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
3bmy:A (HIS77) to (LEU188) DISCOVERY OF BENZISOXAZOLES AS POTENT INHIBITORS OF CHAPERONE HSP90 | CHAPERONE, ATP BINDING DOMAIN, ALTERNATIVE SPLICING, ATP- BINDING, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
5f5r:A (LEU138) to (ILE255) TRAP1N-ADPNP | CHAPERONE, ATPASE, GHKL ATPASE
5f5r:B (LEU138) to (ILE255) TRAP1N-ADPNP | CHAPERONE, ATPASE, GHKL ATPASE
3c0e:A (ILE64) to (LEU175) YEAST HSP82 N-TERMINAL DOMAIN: EFFECTS OF MUTANTS 98-99 KS- AA | GRP94, HSP82, HSP90, HTPG, CHAPERONE, LIGAND, GELDANAMYCIN, ATP-BINDING, CYTOPLASM, NUCLEOTIDE-BINDING, STRESS RESPONSE
4ce3:A (PHE63) to (ARG169) HSP90 N-TERMINAL DOMAIN BOUND TO MACROLACTAM ANALOGUES OF RADICICOL. | CHAPERONE
3opd:A (ARG62) to (LEU173) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM TRYPANOSOMA BRUCEI, TB10.26.1080 IN THE PRESENCE OF A BENZAMIDE DERIVATIVE | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE, ATP BINDING
3opd:C (LEU61) to (LEU173) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM TRYPANOSOMA BRUCEI, TB10.26.1080 IN THE PRESENCE OF A BENZAMIDE DERIVATIVE | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE, ATP BINDING
3owb:A (HIS77) to (LEU188) CRYSTAL STRUCTURE OF HSP90 WITH VER-49009 | HSP90, CHAPERONE
4egh:A (HIS77) to (ARG182) HSP90-ALPHA ATPASE DOMAIN IN COMPLEX WITH (4-HYDROXYPHENYL)MORPHOLIN- 4-YL METHANONE | BERGERAT FOLD, HYDROLASE, ATP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4egi:A (HIS77) to (LEU188) HSP90-ALPHA ATPASE DOMAIN IN COMPLEX WITH 2-AMINO-4-ETHYLTHIO-6- METHYL-1,3,5-TRIAZINE | BERGERAT FOLD, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4egk:A (HIS77) to (LEU188) HUMAN HSP90-ALPHA ATPASE DOMAIN BOUND TO RADICICOL | BERGERAT FOLD, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5in9:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF GRP94 BOUND TO METHYL 3-CHLORO-2-(2-(1-((5- CHLOROFURAN-2-YL)METHYL)-1H-IMIDAZOL-2-YL)ETHYL)-4,6- DIHYDROXYBENZOATE, AN INHIBITOR BASED ON THE BNIM AND RADAMIDE SCAFFOLDS. | CATION-PI INTERACTION, BNIM AND RADAMIDE SCAFFOLD-BASED INHIBITOR, ATP BINDING SITE, CHAPERONE-INHIBITOR COMPLEX
5in9:B (THR133) to (LEU249) CRYSTAL STRUCTURE OF GRP94 BOUND TO METHYL 3-CHLORO-2-(2-(1-((5- CHLOROFURAN-2-YL)METHYL)-1H-IMIDAZOL-2-YL)ETHYL)-4,6- DIHYDROXYBENZOATE, AN INHIBITOR BASED ON THE BNIM AND RADAMIDE SCAFFOLDS. | CATION-PI INTERACTION, BNIM AND RADAMIDE SCAFFOLD-BASED INHIBITOR, ATP BINDING SITE, CHAPERONE-INHIBITOR COMPLEX
3q5j:A (CYS62) to (LEU173) CRYSTAL STRUCTURE OF THE AMINO-TERMINAL DOMAIN OF HSP90 FROM LEISHMANIA MAJOR, LMJF33.0312:M1-K213 IN THE PRESENCE OF 17-DMAP- GELDANAMYCIN | SLEEPING SICKNESS, LEISHMANIA, HEAT SHOCK PROTEIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
3q5k:A (CYS62) to (LEU173) CRYSTAL STRUCTURE OF THE AMINO-TERMINAL DOMAIN OF HSP90 FROM LEISHMANIA MAJOR, LMJF33.0312:M1-K213 IN THE PRESENCE OF AN INHIBITOR | SLEEPING SICKNESS, LEISHMANIA, HEAT SHOCK PROTEIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
3q5l:A (CYS62) to (LEU173) CRYSTAL STRUCTURE OF THE AMINO-TERMINAL DOMAIN OF HSP90 FROM LEISHMANIA MAJOR, LMJF33.0312:M1-K 213 IN THE PRESENCE OF 17-AEP- GELDANAMYCIN | SLEEPING SICKNESS, LEISHMANIA, HEAT SHOCK PROTEIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
3q5l:C (CYS62) to (LEU173) CRYSTAL STRUCTURE OF THE AMINO-TERMINAL DOMAIN OF HSP90 FROM LEISHMANIA MAJOR, LMJF33.0312:M1-K 213 IN THE PRESENCE OF 17-AEP- GELDANAMYCIN | SLEEPING SICKNESS, LEISHMANIA, HEAT SHOCK PROTEIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
3q5l:D (CYS62) to (LEU173) CRYSTAL STRUCTURE OF THE AMINO-TERMINAL DOMAIN OF HSP90 FROM LEISHMANIA MAJOR, LMJF33.0312:M1-K 213 IN THE PRESENCE OF 17-AEP- GELDANAMYCIN | SLEEPING SICKNESS, LEISHMANIA, HEAT SHOCK PROTEIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
4fcp:A (HIS77) to (LEU188) TARGETTING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO [2,3-D] PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION | HSP90, HEAT SHOCK PROTEIN, ATPASE, STRUCTURE-BASED LIGAND DESIGN, FRAGMENT STRUCTURAL STUDIES, CHAPERONE
4fcp:B (HIS77) to (LEU188) TARGETTING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO [2,3-D] PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION | HSP90, HEAT SHOCK PROTEIN, ATPASE, STRUCTURE-BASED LIGAND DESIGN, FRAGMENT STRUCTURAL STUDIES, CHAPERONE
4fcq:A (HIS77) to (LEU188) TARGETING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5- CYANOPYRROLO[2,3-D]PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION | HEAT SHOCK PROTEIN, HSP90, ATPASE, FRAGMENTS, STRUCTURE-BASED DESIGN., CHAPERONE
3r4n:A (HIS77) to (ARG182) OPTIMIZATION OF POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE PYRROLODINOPYRIMIDINE-CONTAINING INHIBITORS OF HEAT SHOCK PROTEIN 90. IDENTIFICATION OF DEVELOPMENT CANDIDATE 2-AMINO-4-{4-CHLORO-2-[2-(4- FLUORO-1H-PYRAZOL-1-YL)ETHOXY]-6-METHYLPHENYL}-N-(2,2- DIFLUOROPROPYL)-5,7-DIHYDRO-6H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXAMIDE | CHAPERONE, ATP BINDING, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3r4o:A (HIS77) to (LEU188) OPTIMIZATION OF POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE PYRROLODINOPYRIMIDINE-CONTAINING INHIBITORS OF HEAT SHOCK PROTEIN 90. IDENTIFICATION OF DEVELOPMENT CANDIDATE 2-AMINO-4-{4-CHLORO-2-[2-(4- FLUORO-1H-PYRAZOL-1-YL)ETHOXY]-6-METHYLPHENYL}-N-(2,2- DIFLUOROPROPYL)-5,7-DIHYDRO-6H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXAMIDE | CHAPERONE, ATP BINDING, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3r4o:B (HIS77) to (LEU188) OPTIMIZATION OF POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE PYRROLODINOPYRIMIDINE-CONTAINING INHIBITORS OF HEAT SHOCK PROTEIN 90. IDENTIFICATION OF DEVELOPMENT CANDIDATE 2-AMINO-4-{4-CHLORO-2-[2-(4- FLUORO-1H-PYRAZOL-1-YL)ETHOXY]-6-METHYLPHENYL}-N-(2,2- DIFLUOROPROPYL)-5,7-DIHYDRO-6H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXAMIDE | CHAPERONE, ATP BINDING, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
4gqt:A (PHE65) to (MET176) N-TERMINAL DOMAIN OF C. ELEGANS HSP90 | STRUCTURAL GENOMICS, APC102132, HSP90, CHAPERONE, ADP, PSI-BIOLOGY, MIDWEST CENTER FOR STRUCTURAL GENOMICS, MCSG
3rlp:A (HIS77) to (LEU188) CO-CRYSTAL STRUCTURE OF THE HSP90 ATP BINDING DOMAIN IN COMPLEX WITH 4-(2,4-DICHLORO-5-METHOXYPHENYL)-6-METHYLPYRIMIDIN-2-AMINE | CHAPERONE
1ah6:A (PHE63) to (LEU175) STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE | CHAPERONE, ATP-BINDING, HEAT SHOCK
1ah8:A (PHE63) to (LEU175) STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE | CHAPERONE, ATP-BINDING, HEAT SHOCK
1ah8:B (PHE63) to (LEU175) STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE | CHAPERONE, ATP-BINDING, HEAT SHOCK
2brc:A (ILE64) to (ARG169) STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. | 3D-STRUCTURE, ATP-BINDING, CHAPERONE, HEAT SHOCK, INHIBITOR, MULTIGENE FAMILY, CHAPERONE/COMPLEX
4xcj:A (GLU66) to (LEU178) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN COMPLEX WITH ADP | HSP90, ADP, CHAPERONE
4xdm:A (GLU66) to (ARG172) N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN COMPLEX WITH GELDANAMYCIN | HSP90, GELDANAMYCIN, CHAPERONE
2cct:A (HIS77) to (LEU188) HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4- PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE | HEAT-SHOCK PROTEIN COMPLEX, HSP90, ATPASE, PYRAZOLE, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION
3tuh:A (HIS77) to (ARG182) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 IN THE PRESENCE OF AN THE INHIBITOR GANETESPIB | CHAPERONE PROTEIN, ATP BINDING, CHAPERONE-INHIBITOR COMPLEX
3tuh:B (HIS77) to (ARG182) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 IN THE PRESENCE OF AN THE INHIBITOR GANETESPIB | CHAPERONE PROTEIN, ATP BINDING, CHAPERONE-INHIBITOR COMPLEX
4ykt:A (HIS77) to (LEU188) HEAT SHOCK PROTEIN 90 BOUND TO CS307 | CHAPERONE, PROTEIN-INHIBITOR COMPLEX, HSP 90, CHAPERONE-INHIBITOR COMPLEX
3hyz:B (HIS77) to (LEU188) CRYSTAL STRUCTURE OF HSP90 WITH FRAGMENT 42-C03 | NUCLEOTIDE BINDING, ATP-BINDING, CHAPERONE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE
1tbw:A (THR133) to (LEU249) LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION | GRP94, HSP90, AMP, BERGRAT, CHAPERONE, ENDOPLASMIC RETICULUM
1uyl:A (HIS77) to (LEU188) STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS | HSP90, ATPASE, CHAPERONE, ATP-BINDING, HEAT SHOCK
3wha:A (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A TRICYCLIC INHIBITOR | CHAPERONE, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
3wha:B (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH A TRICYCLIC INHIBITOR | CHAPERONE, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
2xht:A (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE, INHIBITOR,
2xhx:A (HIS77) to (LEU188) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | HSP90, CHAPERONE, ATP BINDING DOMAIN, N-TERMINAL DOMAIN, STRESS RESPONSE
2xjj:A (HIS77) to (ARG182) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE
2xjj:B (HIS77) to (ARG182) STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND | CHAPERONE
2ye3:A (HIS77) to (ARG182) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2ye9:A (HIS77) to (ARG182) HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING | PU3, ATPASE, CHAPERONE, STRESS RESPONSE, NUCLEOTIDE-BINDING, ATP-BINDING, PHOSPHOPROTEIN, PHOSPHORYLATION
2yi0:A (HIS77) to (LEU188) STRUCTURAL CHARACTERIZATION OF 5-ARYL-4-(5-SUBSTITUTED-2-4- DIHYDROXYPHENYL)-1,2,3-THIADIAZOLE HSP90 INHIBITORS. | CHAPERONE, ATPASE, INHIBITORS
2yjw:A (HIS77) to (ARG182) TRICYCLIC SERIES OF HSP90 INHIBITORS | CHAPERONE, INHIBITION
1yt2:A (THR133) to (LEU249) CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N APO CRYSTAL | GRP94, GP96, HSP90, BERGERAT, CHAPERONE, ENDOPLASMIC RETICULUM, HTPG
3b27:A (HIS77) to (LEU188) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR RO4919127 | CHAPERONE-CHAPERONE INHIBITOR COMPLEX
5fnd:A (HIS77) to (LEU188) DYNAMIC UNDOCKING AND THE QUASI-BOUND STATE AS TOOLS FOR DRUG DESIGN | HSP90, DRUG DESIGN, CHAPERONE, ONCOLOGY
3omu:A (ARG63) to (LEU174) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM TRYPANOSOMA BRUCEI, TB10.26.1080 IN THE PRESENCE OF A THIENOPYRIMIDINE DERIVATIVE | HSP90, TRYPANOSOMA BRUCEII, STRUCTURAL GENOMICS, DRUG DISCOVERY, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
3omu:B (ARG63) to (HIS175) CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF AN HSP90 FROM TRYPANOSOMA BRUCEI, TB10.26.1080 IN THE PRESENCE OF A THIENOPYRIMIDINE DERIVATIVE | HSP90, TRYPANOSOMA BRUCEII, STRUCTURAL GENOMICS, DRUG DISCOVERY, STRUCTURAL GENOMICS CONSORTIUM, SGC, CHAPERONE
4eeh:A (HIS77) to (ARG182) HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR 3-(4- HYDROXY-PHENYL)-1H-INDAZOL-6-OL | ATP BINDING, CHAPERONE-CHAPERONE INHIBITOR COMPLEX
4w7t:A (HIS77) to (LEU188) CRYSTAL STRUCTURE OF HSP90-ALPHA N-DOMAIN BOUND TO THE INHIBITOR NVP- HSP990 | ATP-BINDING DOMAIN, CHAPERONE-INHIBITOR COMPLEX
3r4m:A (HIS77) to (ARG182) OPTIMIZATION OF POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE PYRROLODINOPYRIMIDINE-CONTAINING INHIBITORS OF HEAT SHOCK PROTEIN 90. IDENTIFICATION OF DEVELOPMENT CANDIDATE 2-AMINO-4-{4-CHLORO-2-[2-(4- FLUORO-1H-PYRAZOL-1-YL)ETHOXY]-6-METHYLPHENYL}-N-(2,2- DIFLUOROPROPYL)-5,7-DIHYDRO-6H-PYRROLO[3,4-D]PYRIMIDINE-6-CARBOXAMIDE | CHAPERONE, ATP BINDING, CHAPERONE-CHAPERONE INHIBITOR COMPLEX