4htx:B (MET726) to (THR903) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN COMPLEX WITH BAY60-7550 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3shy:A (SER679) to (GLN859) CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS | PDE5A INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3shz:A (SER679) to (GLN860) CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS | PDE5A INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sie:A (PHE686) to (GLN860) CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS | PDE5A INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3g45:A (SER463) to (ILE656) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4B WITH REGULATORY DOMAIN AND D155988 | PHOSPHODIESTERASE, ALTERNATIVE SPLICING, CAMP, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
3tge:A (LEU681) to (ALA857) A NOVEL SERIES OF POTENT AND SELECTIVE PDE5 INHIBITOR1 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tgg:A (LEU681) to (ALA857) A NOVEL SERIES OF POTENT AND SELECTIVE PDE5 INHIBITOR2 | PHOSPHODIESTERASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gwt:A (LEU303) to (GLN467) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A QUINOLINE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, HYDROLASE
3tvx:A (ASN421) to (ILE622) THE STRUCTURE OF PDE4A WITH PENTOXIFYLLINE AT 2.84A RESOLUTION | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1f0j:A (ASN283) to (ILE484) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B | PDE PHOSPHODIESTERASE, HYDROLASE
1f0j:B (SER291) to (ILE484) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B | PDE PHOSPHODIESTERASE, HYDROLASE
1rkp:A (MET681) to (GLU858) CRYSTAL STRUCTURE OF PDE5A1-IBMX | PDE5A, VIAGRA, IBMX, HYDROLASE
1ro9:B (SER291) to (ILE484) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP | PDE, 8-BR-AMP, HYDROLASE
1ror:B (LEU303) to (ILE484) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP | PDE, AMP, HYDROLASE
3hmv:A (SER301) to (GLN467) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A TETRAHYDROBENZOTHIOPHENE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
3v93:F (GLY436) to (GLY611) UNLIGANDED STRUCTURE OF TCRPDEC1 CATALYTIC DOMAIN | PARASITE, PHOSPHODIESTERASES,, HYDROLASE
3ibj:A (SER724) to (HIS900) X-RAY STRUCTURE OF PDE2A | PHOSPHODIESTERASE, PDE2A, GAF-DOMAINS, ALLOSTERIC REGULATION, CGMP, HYDROLASE, MEMBRANE
1t9s:A (LEU681) to (GLU858) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH GMP | HYDROLASE, PDE5A
1t9s:B (LEU681) to (GLU858) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH GMP | HYDROLASE, PDE5A
1tbf:A (LEU681) to (GLU858) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH SILDENAFIL | PDE5A, HYDROLASE
2h40:A (SER679) to (GLU858) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF UNLIGANDED PDE5 | PDE5, UNLIGANDED, HYDROLASE
2h42:B (SER679) to (GLN859) CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH SILDENAFIL | VIAGRA, PDE5, HYDROLASE
3itm:A (HIS729) to (SER899) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itm:B (HIS729) to (LYS897) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itm:C (HIS729) to (THR896) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itu:A (MET726) to (ILE904) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
3itu:B (SER724) to (ILE904) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
3itu:D (MET726) to (ILE904) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
4oew:A (SER679) to (GLN860) CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4oex:A (SER679) to (GLU858) CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xlz:B (SER282) to (MET483) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH FILAMINAST | PDE4B, FILAMINAST, HYDROLASE
1xm4:A (LEU303) to (GLN467) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH PICLAMILAST | PDE4B, PICLAMILAST, HYDROLASE
1xm4:B (SER291) to (MET483) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH PICLAMILAST | PDE4B, PICLAMILAST, HYDROLASE
1xm6:B (LEU303) to (MET483) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)- MESOPRAM | PDE4B, (R)-MESOPRAM, HYDROLASE
1xoz:A (LEU681) to (GLU858) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH TADALAFIL | PHOSPHODIESTERASE, PDE, PDE5A, TADALAFIL, CIALIS, HYDROLASE
1xp0:A (GLU682) to (GLU858) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH VARDENAFIL | PHOSPHODIESTERASE, PDE, PDE5A, VARDENAFIL, LEVITRA, HYDROLASE
4pm0:A (SER279) to (LEU454) PDE7A CATALYTIC DOMAIN IN COMPLEX WITH 2-(CYCLOPENTYLAMINO)THIENO[3,2- D]PYRIMIDIN-4(3H)-ONE DERIVATIVE | PHOSPHODIESTERASE, PDE7, HYDROLASE
1zkl:A (SER279) to (LEU454) MULTIPLE DETERMINANTS FOR INHIBITOR SELECTIVITY OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES | PDE, HYDROLASE
3ly2:D (SER282) to (ILE484) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:F (SER282) to (ILE484) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:H (ASN283) to (ILE484) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3b2r:A (ASP687) to (GLU858) CRYSTAL STRUCTURE OF PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH VARDENAFIL | CGMP PHOSPHODIESTERASE; PDE5-INHIBITOR POTENCY; VARDENAFIL; SILDENAFIL; LEVITRATM., ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, ZINC
3b2r:B (PHE686) to (GLU858) CRYSTAL STRUCTURE OF PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH VARDENAFIL | CGMP PHOSPHODIESTERASE; PDE5-INHIBITOR POTENCY; VARDENAFIL; SILDENAFIL; LEVITRATM., ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, ZINC
3bjc:A (SER679) to (GLU858) CRYSTAL STRUCTURE OF THE PDE5A CATALYTIC DOMAIN IN COMPLEX WITH A NOVEL INHIBITOR | PDE5, ERECTILE DYSFUNCTION, CRYSTAL STRUCTURE, INHIBITOR DESIGN, ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP, CGMP- BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, ZINC
4c1i:C (MET726) to (VAL898) SELECTIVE INHIBITORS OF PDE2, PDE9, AND PDE10: MODULATORS OF ACTIVITY OF THE CENTRAL NERVOUS SYSTEM | HYDROLASE, HYDROLASE INHIBITOR COMPLEX
4c1i:D (MET726) to (VAL898) SELECTIVE INHIBITORS OF PDE2, PDE9, AND PDE10: MODULATORS OF ACTIVITY OF THE CENTRAL NERVOUS SYSTEM | HYDROLASE, HYDROLASE INHIBITOR COMPLEX
3d3p:A (LEU303) to (ILE484) CRYSTAL STRUCTURE OF PDE4B CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIDINE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
4d09:B (MET726) to (ILE904) PDE2A CATALYTIC DOMAIN IN COMPLEX WITH A BRAIN PENETRANT INHIBITOR | HYDROLASE, CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2, TYPE 4, DISEASE MODELS, ANIMAL, DRUG EVALUATION, PRECLINICAL, PHOSPHODIESTERASE 2 INHIBITORS, PHOSPHODIESTERASE INHIBITORS, PROTEIN BINDING, STRUCTURE-ACTIVITY RELATIONSHIP
4g2y:A (SER679) to (ALA857) CRYSTAL STRUCTURE OF PDE5A COMPLEXED WITH ITS INHIBITOR | PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i9z:A (SER679) to (ALA857) CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jib:A (MET726) to (ILE904) CRYSTAL STRUCTURE OF OF PDE2-INHIBITOR COMPLEX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2h44:A (HIS684) to (GLU858) CRYSTAL STRUCTURE OF PDE5A1 IN COMPLEX WITH ICARISID II | ICARISID II, FLAVONOID, PDE5A INHIBITOR, HYDROLASE
4md6:A (SER679) to (GLU858) CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH INHIBITOR 5R | PROTEIN-INHIBITOR COMPLEX, PHOSPHODIESTERASE, PDE5 INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3jwq:A (MET681) to (GLN859) CRYSTAL STRUCTURE OF CHIMERIC PDE5/PDE6 CATALYTIC DOMAIN COMPLEXED WITH SILDENAFIL | MOSTLY ALPHA, ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, CELL MEMBRANE, LIPOPROTEIN, MEMBRANE, METHYLATION, PRENYLATION, SENSORY TRANSDUCTION, VISION
3jwq:C (MET681) to (GLN859) CRYSTAL STRUCTURE OF CHIMERIC PDE5/PDE6 CATALYTIC DOMAIN COMPLEXED WITH SILDENAFIL | MOSTLY ALPHA, ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, CELL MEMBRANE, LIPOPROTEIN, MEMBRANE, METHYLATION, PRENYLATION, SENSORY TRANSDUCTION, VISION
3jwq:D (MET681) to (GLN859) CRYSTAL STRUCTURE OF CHIMERIC PDE5/PDE6 CATALYTIC DOMAIN COMPLEXED WITH SILDENAFIL | MOSTLY ALPHA, ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, CELL MEMBRANE, LIPOPROTEIN, MEMBRANE, METHYLATION, PRENYLATION, SENSORY TRANSDUCTION, VISION
1xmu:A (LEU303) to (MET483) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4B, ROFLUMILAST, HYDROLASE
1y2h:B (LEU303) to (MET483) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 1-(2- CHLORO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE
1mkd:L (LEU326) to (GLN490) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE