4htx:B   (MET726) to   (THR903)  CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN COMPLEX WITH BAY60-7550  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3shy:A   (SER679) to   (GLN859)  CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS  |   PDE5A INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3shz:A   (SER679) to   (GLN860)  CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS  |   PDE5A INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3sie:A   (PHE686) to   (GLN860)  CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS  |   PDE5A INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3g45:A   (SER463) to   (ILE656)  CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4B WITH REGULATORY DOMAIN AND D155988  |   PHOSPHODIESTERASE, ALTERNATIVE SPLICING, CAMP, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM 
3tge:A   (LEU681) to   (ALA857)  A NOVEL SERIES OF POTENT AND SELECTIVE PDE5 INHIBITOR1  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3tgg:A   (LEU681) to   (ALA857)  A NOVEL SERIES OF POTENT AND SELECTIVE PDE5 INHIBITOR2  |   PHOSPHODIESTERASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3gwt:A   (LEU303) to   (GLN467)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A QUINOLINE INHIBITOR  |   PDE, PHOSPHODIESTERASE, CAMP, HYDROLASE 
3tvx:A   (ASN421) to   (ILE622)  THE STRUCTURE OF PDE4A WITH PENTOXIFYLLINE AT 2.84A RESOLUTION  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1f0j:A   (ASN283) to   (ILE484)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B  |   PDE PHOSPHODIESTERASE, HYDROLASE 
1f0j:B   (SER291) to   (ILE484)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B  |   PDE PHOSPHODIESTERASE, HYDROLASE 
1rkp:A   (MET681) to   (GLU858)  CRYSTAL STRUCTURE OF PDE5A1-IBMX  |   PDE5A, VIAGRA, IBMX, HYDROLASE 
1ro9:B   (SER291) to   (ILE484)  CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP  |   PDE, 8-BR-AMP, HYDROLASE 
1ror:B   (LEU303) to   (ILE484)  CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP  |   PDE, AMP, HYDROLASE 
3hmv:A   (SER301) to   (GLN467)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A TETRAHYDROBENZOTHIOPHENE INHIBITOR  |   PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM 
3v93:F   (GLY436) to   (GLY611)  UNLIGANDED STRUCTURE OF TCRPDEC1 CATALYTIC DOMAIN  |   PARASITE, PHOSPHODIESTERASES,, HYDROLASE 
3ibj:A   (SER724) to   (HIS900)  X-RAY STRUCTURE OF PDE2A  |   PHOSPHODIESTERASE, PDE2A, GAF-DOMAINS, ALLOSTERIC REGULATION, CGMP, HYDROLASE, MEMBRANE 
1t9s:A   (LEU681) to   (GLU858)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH GMP  |   HYDROLASE, PDE5A 
1t9s:B   (LEU681) to   (GLU858)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH GMP  |   HYDROLASE, PDE5A 
1tbf:A   (LEU681) to   (GLU858)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH SILDENAFIL  |   PDE5A, HYDROLASE 
2h40:A   (SER679) to   (GLU858)  CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF UNLIGANDED PDE5  |   PDE5, UNLIGANDED, HYDROLASE 
2h42:B   (SER679) to   (GLN859)  CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH SILDENAFIL  |   VIAGRA, PDE5, HYDROLASE 
3itm:A   (HIS729) to   (SER899)  CATALYTIC DOMAIN OF HPDE2A  |   ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE 
3itm:B   (HIS729) to   (LYS897)  CATALYTIC DOMAIN OF HPDE2A  |   ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE 
3itm:C   (HIS729) to   (THR896)  CATALYTIC DOMAIN OF HPDE2A  |   ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE 
3itu:A   (MET726) to   (ILE904)  HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX  |   ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM 
3itu:B   (SER724) to   (ILE904)  HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX  |   ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM 
3itu:D   (MET726) to   (ILE904)  HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX  |   ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM 
4oew:A   (SER679) to   (GLN860)  CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4oex:A   (SER679) to   (GLU858)  CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xlz:B   (SER282) to   (MET483)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH FILAMINAST  |   PDE4B, FILAMINAST, HYDROLASE 
1xm4:A   (LEU303) to   (GLN467)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH PICLAMILAST  |   PDE4B, PICLAMILAST, HYDROLASE 
1xm4:B   (SER291) to   (MET483)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH PICLAMILAST  |   PDE4B, PICLAMILAST, HYDROLASE 
1xm6:B   (LEU303) to   (MET483)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)- MESOPRAM  |   PDE4B, (R)-MESOPRAM, HYDROLASE 
1xoz:A   (LEU681) to   (GLU858)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH TADALAFIL  |   PHOSPHODIESTERASE, PDE, PDE5A, TADALAFIL, CIALIS, HYDROLASE 
1xp0:A   (GLU682) to   (GLU858)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH VARDENAFIL  |   PHOSPHODIESTERASE, PDE, PDE5A, VARDENAFIL, LEVITRA, HYDROLASE 
4pm0:A   (SER279) to   (LEU454)  PDE7A CATALYTIC DOMAIN IN COMPLEX WITH 2-(CYCLOPENTYLAMINO)THIENO[3,2- D]PYRIMIDIN-4(3H)-ONE DERIVATIVE  |   PHOSPHODIESTERASE, PDE7, HYDROLASE 
1zkl:A   (SER279) to   (LEU454)  MULTIPLE DETERMINANTS FOR INHIBITOR SELECTIVITY OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES  |   PDE, HYDROLASE 
3ly2:D   (SER282) to   (ILE484)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR  |   PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
3ly2:F   (SER282) to   (ILE484)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR  |   PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
3ly2:H   (ASN283) to   (ILE484)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR  |   PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
3b2r:A   (ASP687) to   (GLU858)  CRYSTAL STRUCTURE OF PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH VARDENAFIL  |   CGMP PHOSPHODIESTERASE; PDE5-INHIBITOR POTENCY; VARDENAFIL; SILDENAFIL; LEVITRATM., ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, ZINC 
3b2r:B   (PHE686) to   (GLU858)  CRYSTAL STRUCTURE OF PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH VARDENAFIL  |   CGMP PHOSPHODIESTERASE; PDE5-INHIBITOR POTENCY; VARDENAFIL; SILDENAFIL; LEVITRATM., ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, ZINC 
3bjc:A   (SER679) to   (GLU858)  CRYSTAL STRUCTURE OF THE PDE5A CATALYTIC DOMAIN IN COMPLEX WITH A NOVEL INHIBITOR  |   PDE5, ERECTILE DYSFUNCTION, CRYSTAL STRUCTURE, INHIBITOR DESIGN, ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP, CGMP- BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, ZINC 
4c1i:C   (MET726) to   (VAL898)  SELECTIVE INHIBITORS OF PDE2, PDE9, AND PDE10: MODULATORS OF ACTIVITY OF THE CENTRAL NERVOUS SYSTEM  |   HYDROLASE, HYDROLASE INHIBITOR COMPLEX 
4c1i:D   (MET726) to   (VAL898)  SELECTIVE INHIBITORS OF PDE2, PDE9, AND PDE10: MODULATORS OF ACTIVITY OF THE CENTRAL NERVOUS SYSTEM  |   HYDROLASE, HYDROLASE INHIBITOR COMPLEX 
3d3p:A   (LEU303) to   (ILE484)  CRYSTAL STRUCTURE OF PDE4B CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIDINE INHIBITOR  |   PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM 
4d09:B   (MET726) to   (ILE904)  PDE2A CATALYTIC DOMAIN IN COMPLEX WITH A BRAIN PENETRANT INHIBITOR  |   HYDROLASE, CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2, TYPE 4, DISEASE MODELS, ANIMAL, DRUG EVALUATION, PRECLINICAL, PHOSPHODIESTERASE 2 INHIBITORS, PHOSPHODIESTERASE INHIBITORS, PROTEIN BINDING, STRUCTURE-ACTIVITY RELATIONSHIP 
4g2y:A   (SER679) to   (ALA857)  CRYSTAL STRUCTURE OF PDE5A COMPLEXED WITH ITS INHIBITOR  |   PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i9z:A   (SER679) to   (ALA857)  CRYSTAL STRUCTURE OF THE PDE5A1 CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4jib:A   (MET726) to   (ILE904)  CRYSTAL STRUCTURE OF OF PDE2-INHIBITOR COMPLEX  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2h44:A   (HIS684) to   (GLU858)  CRYSTAL STRUCTURE OF PDE5A1 IN COMPLEX WITH ICARISID II  |   ICARISID II, FLAVONOID, PDE5A INHIBITOR, HYDROLASE 
4md6:A   (SER679) to   (GLU858)  CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH INHIBITOR 5R  |   PROTEIN-INHIBITOR COMPLEX, PHOSPHODIESTERASE, PDE5 INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3jwq:A   (MET681) to   (GLN859)  CRYSTAL STRUCTURE OF CHIMERIC PDE5/PDE6 CATALYTIC DOMAIN COMPLEXED WITH SILDENAFIL  |   MOSTLY ALPHA, ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, CELL MEMBRANE, LIPOPROTEIN, MEMBRANE, METHYLATION, PRENYLATION, SENSORY TRANSDUCTION, VISION 
3jwq:C   (MET681) to   (GLN859)  CRYSTAL STRUCTURE OF CHIMERIC PDE5/PDE6 CATALYTIC DOMAIN COMPLEXED WITH SILDENAFIL  |   MOSTLY ALPHA, ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, CELL MEMBRANE, LIPOPROTEIN, MEMBRANE, METHYLATION, PRENYLATION, SENSORY TRANSDUCTION, VISION 
3jwq:D   (MET681) to   (GLN859)  CRYSTAL STRUCTURE OF CHIMERIC PDE5/PDE6 CATALYTIC DOMAIN COMPLEXED WITH SILDENAFIL  |   MOSTLY ALPHA, ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, CELL MEMBRANE, LIPOPROTEIN, MEMBRANE, METHYLATION, PRENYLATION, SENSORY TRANSDUCTION, VISION 
1xmu:A   (LEU303) to   (MET483)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST  |   PHOSPHODIESTERASE, PDE, PDE4B, ROFLUMILAST, HYDROLASE 
1y2h:B   (LEU303) to   (MET483)  CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 1-(2- CHLORO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER  |   PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE 
1mkd:L   (LEU326) to   (GLN490)  CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX  |   PDE, ZARDAVERINE, HYDROLASE