1a8k:E (VAL11) to (ARG87) CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, PROTON-MEDIATED INTERACTION, VIRAL MATURATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aoc:A (GLN18) to (ARG87) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A SUBSTRATE ANALOG P2-NC | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aod:A (GLN18) to (ARG87) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P2-NC | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aof:A (GLN18) to (ARG87) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P1-P6 | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aoh:B (VAL111) to (ARG187) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P6-PR | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ec0:A (VAL11) to (GLY86) HIGH RESOLUTION HIV-2 PROTEASE STRUCTURE IN COMPLEX WITH ANTIVIRAL INHIBITOR GRL-06579A | HIV-2, ASPARTIC PROTEASE, INHIBITOR, PROTEASE-INHIBITOR COMPLEX, HYDROLASE
3ecg:A (VAL11) to (GLY86) HIGH RESOLUTION HIV-2 PROTEASE STRUCTURE IN COMPLEX WITH ANTIVIRAL INHIBITOR GRL-98065 | HIV-2, ASPARTIC PROTEASE, INHIBITOR, PROTEASE-INHIBITOR COMPLEX, HYDROLASE
1aaq:B (PRO9) to (ARG87) HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS | ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1nh0:A (VAL11) to (ARG87) 1.03 A STRUCTURE OF HIV-1 PROTEASE: INHIBITOR BINDING INSIDE AND OUTSIDE THE ACTIVE SITE | ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS, INHIBITOR DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2avm:A (GLN18) to (ARG87) KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S | HIV-1 PROTEASE, DRUG RESISTANCE, SUBSTRATE ANALOG, NON-ACTIVE SITE MUTANTS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1aid:B (ARG8) to (ARG87) STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN | HYDROLASE, PROTEASE, HIV, NON-PEPTIDE INHIBITOR, DRUG DESIGN
2az8:A (ARG8) to (ARG87) HIV-1 PROTEASE NL4-3 IN COMPLEX WITH INHIBITOR, TL-3 | HIV-1, PROTEASE, INHIBITOR, TL-3, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3em4:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF ATAZANAVIR (ATV) IN COMPLEX WITH I50L/A71V DRUG- RESISTANT HIV-1 PROTEASE | DRUG RESISTANCE, HYPERSUSCEPTIBILITY, PROTEASE INHIBITOR, HIV, ATAZANAVIR, AIDS, HYDROLASE, PROTEASE
2bbb:A (VAL11) to (ARG87) STRUCTURE OF HIV1 PROTEASE AND HH1_173_3A COMPLEX. | PROTEASE, HYDROLASE
2p3c:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF THE SUBTYPE F WILD TYPE HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | WILD TYPE SUBTYPE F HIV PROTEASE, TL-3 INHIBITOR, NON-B HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p3c:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF THE SUBTYPE F WILD TYPE HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | WILD TYPE SUBTYPE F HIV PROTEASE, TL-3 INHIBITOR, NON-B HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p3d:A (ARG8) to (ARG87) CRYSTAL STRUCTURE OF THE MULTI-DRUG RESISTANT MUTANT SUBTYPE F HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | MULTI-DRUG RESISTANT MUTANT SUBTYPE F HIV PROTEASE, TL-3 INHIBITOR, NON-B HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p3d:B (ARG8) to (ARG87) CRYSTAL STRUCTURE OF THE MULTI-DRUG RESISTANT MUTANT SUBTYPE F HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | MULTI-DRUG RESISTANT MUTANT SUBTYPE F HIV PROTEASE, TL-3 INHIBITOR, NON-B HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hdf:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS V82A COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4heg:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS R8Q COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pc0:A (VAL1011) to (ARG1087) APO WILD-TYPE HIV PROTEASE IN THE OPEN CONFORMATION | HIV PROTEASE, HYDROLASE
3s45:A (VAL11) to (GLY86) WILD-TYPE HIV-2 PROTEASE WITH ANTIVIRAL DRUG AMPRENAVIR | AMPRENAVIR, HIV/AIDS, DRUG RESISTANCE, ASPARTIC PROTEASE, MOLECULAR RECOGNITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bv9:A (PRO9) to (GLY86) HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS | HIV-1 PROTEASE (I84V) XV638, HYDROLASE
1bwb:A (PRO9) to (ARG87) HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS | HIV-1 PROTEASE, HYDROLASE
1ody:A (PRO9) to (ARG87) HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | ASPARTIC PROTEASE, RETROPEPSIN, RETROVIRUS, HIV, AIDS
1ody:B (ARG8) to (ARG87) HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | ASPARTIC PROTEASE, RETROPEPSIN, RETROVIRUS, HIV, AIDS
4hvp:B (THR12) to (ARG87) STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A SUBSTRATE- BASED INHIBITOR AT 2.3 ANGSTROMS RESOLUTION | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pk5:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K, L33I, L63I ) IN COMPLEX WITH KNI-10075 | PROTEASE COMPLEX, VIRAL PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pwr:A (VAL11) to (ARG87) HIV-1 PROTEASE IN COMPLEX WITH A CARBAMOYL DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, HYDROLASE
4i8z:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH NON- PEPTIDIC INHIBITOR, GRL008 | HIV-1 PROTEASE, HIV-1 PROTEASE-INHIBITOR COMPLEX, HYDROLASE, GRL008, NON-PEPTIDIC INHIBITOR, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3spk:B (PRO9) to (ARG87) TIPRANAVIR IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT | TIPRANAVIR, MULTI-DRUG RESISTANT HIV-1 PROTEASE, HYDORLASE-HYDORLASE INHIBITOR COMPLEX
2q64:A (PRO9) to (ARG87) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
2q64:B (PRO9) to (ARG87) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
3t11:A (VAL11) to (ARG87) DIMERIC INHIBITOR OF HIV-1 PROTEASE. | HIV-1 PROTEASE, BETA BAREL, RETROVIRAL ASPARTYL PROTEASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2qmp:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH PL-100 | HIV-1 PROTEASE, ASPARTYL PROTEASE, HYDROLASE, MULTIFUNCTIONAL ENZYME, NUCLEOTIDYLTRANSFERASE, RNA- DIRECTED DNA POLYMERASE, TRANSFERASE
3gga:A (VAL11) to (ARG87) HIV PROTEASE INHIBITORS WITH PSEUDO-SYMMETRIC CORES | PSEUDO-SYMMETRICAL HIV PROTEASE INHIBITORS, HYDROLASE, PROTEASE
1pro:B (PRO9) to (ARG87) HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881 | AIDS, POLYPROTEIN, HYDROLASE, ASPARTIC PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE, HYDROLASE (ASPARTIC PROTEASE)
2r38:A (PRO9) to (ILE85) I84V HIV-1 PROTEASE MUTANT IN COMPLEX WITH A CARBAMOYL DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, ASPARTYL PROTEASE, HYDROLASE, PROTEASE
2r38:B (ARG8) to (ARG87) I84V HIV-1 PROTEASE MUTANT IN COMPLEX WITH A CARBAMOYL DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, ASPARTYL PROTEASE, HYDROLASE, PROTEASE
2r3t:A (GLN18) to (ARG87) I50V HIV-1 PROTEASE MUTANT IN COMPLEX WITH A CARBAMOYL DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, ASPARTYL PROTEASE, HYDROLASE, PROTEASE
1ebk:E (GLN18) to (ARG87) STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2r8n:A (ARG8) to (GLY86) STRUCTURAL ANALYSIS OF THE UNBOUND FORM OF HIV-1 SUBTYPE C PROTEASE | HIV-1 SUBTYPE C, ASPARTYL PROTEASE, HYDROLASE, MULTIFUNCTIONAL ENZYME, NUCLEOTIDYLTRANSFERASE, PROTEASE, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE
1qbt:B (PRO9) to (ARG87) HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY | HYDROLASE (ACID PROTEINASE), ASPARTYL PROTEASE
1qbu:A (PRO9) to (GLY86) HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY | HYDROLASE (ACID PROTEINASE), ASPARTYL PROTEASE
2rkf:A (PRO9) to (ARG87) HIV-1 PR RESISTANT MUTANT + LPV | RESISTENCE, INSERTION, HYDROLASE
2rkf:B (PRO9) to (ARG87) HIV-1 PR RESISTANT MUTANT + LPV | RESISTENCE, INSERTION, HYDROLASE
3hdk:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED [AIB51/51']HIV-1 PROTEASE | BETA BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1fff:C (VAL11) to (ARG87) STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES. | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uf3:A (THR12) to (ARG87) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 | HYDROLASE
4z4x:A (THR12) to (ARG87) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20D25N WITH OPEN FLAP | HIV-1 PROTEASE, HYDROLASE
2fns:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF WILD-TYPE INACTIVE (D25N) HIV-1 PROTEASE COMPLEXED WITH WILD-TYPE HIV-1 NC-P1 SUBSTRATE. | STRUCTURAL INTERMEDIATE, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, NC-P1 SUBSTRATE, DRUG RESISTANCE, FLAP CONFORMATION, HYDROLASE
3hvp:A (VAL11) to (GLY86) CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE | HYDROLASE(ACID PROTEINASE)
1siv:B (VAL11) to (ARG87) THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, ACID PROTEINASE
2g69:A (GLN18) to (ARG87) STRUCTURE OF UNLIGANDED HIV-1 PROTEASE F53L MUTANT | ASPARTIC PROTEASE, CATALYSIS, UNLIGANDED, FLAP MUTANT, NON-ACTIVE SITE MUTANT, HYDROLASE
3iaw:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [GLY51;AIB51']HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR AT 1.6 A RESOLUTION | ASYMMETRIC DIMER, COVALENT DIMER, BETA-SHEET, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1hhp:A (ARG8) to (ARG87) THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV- 1 ISOLATE BRU | HYDROLASE(ACID PROTEINASE)
1htf:A (VAL11) to (ARG87) X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN- DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE | HYDROLASE(ACID PROTEINASE)
1hvh:B (PRO9) to (ARG87) NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS | HYDROLASE, ACID PROTEASE
1hwr:A (PRO9) to (ARG87) MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS | ASPARTYL PROTEASE, HYDROLASE, ACID PROTEINASE
5agz:B (VAL111) to (ARG187) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON- PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
1jld:B (PRO9) to (GLY86) POTENT HIV PROTEASE INHIBITORS CONTAINING A NOVEL (HYDROXYETHYL)AMIDE ISOSTERE | POLYPROTEIN, HIV-2 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, AIDS
4npt:A (ARG8) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MULTIPLE MUTANT P51 COMPLEXED WITH DARUNAVIR | HIV-1 PROTEASE, DARUNAVIR, P51, MULTIPLE MUTANT, DRUG RESISTANCE, HYDROLASE
4npu:A (ARG8) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MULTIPLE MUTANT P51 | HIV-1 PROTEASE, P51, MULTIPLE MUTANT, DRUG RESISTANCE, HYDROLASE
4npu:B (ARG108) to (ARG187) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MULTIPLE MUTANT P51 | HIV-1 PROTEASE, P51, MULTIPLE MUTANT, DRUG RESISTANCE, HYDROLASE
2nnk:A (VAL11) to (ARG87) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A INHIBITOR SAQUINAVIR | HIV-1 PROTEASE, MUTANT, I84V, DIMER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3jvy:A (GLN18) to (ARG87) HIV-1 PROTEASE MUTANT G86A WITH DARUNAVIR | HIV-1 PROTEASE, MUTANT G86A, INHIBITOR, DARUNAVIR, AIDS, ASPARTYL PROTEASE, HYDROLASE, METAL-BINDING
4obd:D (VAL11) to (ARG87) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F/S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASES, HYDROLASE
4obg:D (VAL11) to (GLY86) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE. | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obk:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F/S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
1xl2:B (VAL11) to (ARG87) HIV-1 PROTEASE IN COMPLEX WITH PYRROLIDINMETHANAMINE | ASPARTYL PROTEASE; HIV PROTEASE; PYRROLIDINE INHIBITOR, HYDROLASE
1mes:B (PRO9) to (ARG87) HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
1meu:A (PRO9) to (ARG87) HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
1meu:B (PRO9) to (ARG87) HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
1n49:D (GLN18) to (ARG87) VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE VARIANT: STRUCTURAL INSIGHTS FOR BETTER ANTI-VIRAL THERAPY | HIV-1 PROTEASE, DRUG RESISTANCE, SUBSTRATE RECOGNITION, INHIBITOR BINDING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1z1r:B (VAL111) to (ARG187) HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 2 | MACROCYCLIC INHIBITORS, PEPTIDOMIMETIC INHIBITORS, HIV1 PROTEASE, HYDROLASE
1z8c:A (ARG8) to (ARG87) CRYSTAL STRUCTURE OF THE COMPLEX OF MUTANT HIV-1 PROTEASE (L63P, A71V, V82T, I84V) WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR BOC- PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q1w:B (VAL11) to (ARG87) MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE | HIV-1 PROTEASE, AIDS, INHIBITOR COMPLEX, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q1y:B (VAL11) to (ARG87) MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE | HIV-1 PROTEASE, AIDS, INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3lzs:B (PRO9) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 CRF01_AE PROTEASE IN COMPLEX WITH DARUNAVIR | HIV-1 PROTEASE, NON-B CLADES, CRF01_AE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, HYDROLASE
4qj7:C (VAL11) to (ARG87) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (R452S) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj8:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (P453L) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qja:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (P453L) | CO-EVOLUTION, PROTEASE, HYDROLASE
3b7v:A (GLN18) to (ARG87) HIV-1 PROTEASE COMPLEXED WITH GEM-DIOL-AMINE TETRAHEDRAL INTERMEDIATE NLLTQI | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3mxd:B (ARG8) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE INHIBITOR KC53 IN COMPLEX WITH WILD-TYPE PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3bva:A (GLN18) to (ARG87) CYSTAL STRUCTURE OF HIV-1 ACTIVE SITE MUTANT D25N AND P2-NC ANALOG INHIBITOR | DRUG RESISTANCE, HIV-1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3n3i:A (GLN1018) to (GLY1086) CRYSTAL STRUCTURE OF G48V/C95F TETHERED HIV-1 PROTEASE/SAQUINAVIR COMPLEX | HIV-1 PROTEASE, SAQUINAVIR, DRUG RESISTANCE, TETHERED-DIMER, FUSION PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu6:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I54M WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, AMPRENAVIR, CONFORMATIONAL CHANGE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nuo:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT L90M WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3cyw:B (VAL11) to (ARG87) EFFECT OF FLAP MUTATIONS ON STRUCTURE OF HIV-1 PROTEASE AND INHIBITION BY SAQUINAVIR AND DARUNAVIR | DRUG RESISTANCE; HIV-1, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC-FINGER
3d3t:A (PRO9) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 CRF01_AE IN COMPLEX WITH THE SUBSTRATE P1- P6 | HIV-1 PROTEASE, NON-B CLADES, CRF01_AE, P1-P6 SUBSTRATE, AIDS, ASPARTYL PROTEASE, HYDROLASE
3o9e:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF60 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ogp:A (PRO14) to (GLY103) CRYSTAL STRUCTURE OF 6S-98S FIV PROTEASE WITH DARUNAVIR BOUND | ASPARTYL PROTEASE, HIV-LIKE FIV CHIMERA, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4u7v:A (PRO9) to (ARG87) STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH DEGRADED PHOTOSENSITIVE INHIBITOR | HIV-1, VIRAL PROTEASE, ASPARTIC PROTEASE, INHIBITION, HYDROLASE
4u7v:B (PRO9) to (ARG87) STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH DEGRADED PHOTOSENSITIVE INHIBITOR | HIV-1, VIRAL PROTEASE, ASPARTIC PROTEASE, INHIBITION, HYDROLASE
4u8w:B (VAL11) to (ARG87) HIV-1 WILD TYPE PROTEASE WITH GRL-050-10A (A GEM-DIFLUORO-BIS- TETRAHYDROFURAN AS P2-LIGAND) | HIV-1 PROTEASE INHIBITOR, MULTIDRUG-RESISTANT HIV-1 STRAINS, BLOOD- BRAIN-BARRIER, FLUORO-BIS-THF, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqf:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF (G16A/L38A) HIV-1 PROTEASE IN COMPLEX WITH DRV | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqg:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF APO(G16C/L38C) HIV-1 PROTEASE | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4eq0:A (VAL111) to (ARG187) CRYSTAL STRUCTURE OF INACTIVE SINGLE CHAIN VARIANT OF HIV-1 PROTEASE IN COMPLEX WITH THE SUBSTRATE P2-NC | HIV-1 PROTEASE, SPECIFICITY DESIGN, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE SUBSTRATE COMPLEX
4eqj:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF INACTIVE SINGLE CHAIN VARIANT OF HIV-1 PROTEASE IN COMPLEX WITH THE SUBSTRATE RT-RH | HIV-1 PROTEASE, SPECIFICITY DESIGN, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE SUBSTRATE COMPLEX
3qbf:A (VAL11) to (ARG87) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qih:A (VAL11) to (ARG87) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A NOVEL INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qpj:A (VAL11) to (ARG87) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qrs:A (VAL11) to (ARG87) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qrs:B (VAL11) to (ARG87) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fl8:A (GLN18) to (ARG87) HIV-1 PROTEASE COMPLEXED WITH GEM-DIOL-AMINE TETRAHEDRAL INTERMEDIATE | HYDROLASE, CATALYTIC MECHANISM, DRUG RESISTANCE, ASPARTIC PROTEASE
4flg:B (VAL11) to (ARG87) HIV-1 PROTEASE MUTANT I47V COMPLEXED WITH REACTION INTERMEDIATE | HYDROLASE, CATALYTIC MECHANISM, DRUG RESISTANCE, ASPARTIC PROTEASE
4fm6:B (GLN18) to (ARG87) HIV-1 PROTEASE MUTANT V32I COMPLEXED WITH REACTION INTERMEDIATE | HYDROLASE, CATALYTIC MECHANISM, DRUG RESISTANCE, ASPARTIC PROTEASE
7hvp:B (ILE13) to (ARG87) X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1az5:A (VAL11) to (ARG87) UNLIGANDED SIV PROTEASE STRUCTURE IN AN "OPEN" CONFORMATION | HIV, AIDS, PROTEINASE, ASPARTYL PROTEASE, ENDONUCLEASE
1c70:B (PRO209) to (ARG287) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE
3t3c:B (PRO9) to (ILE85) STRUCTURE OF HIV PR RESISTANT PATIENT DERIVED MUTANT (COMPRISING 22 MUTATIONS) IN COMPLEX WITH DRV | PEPTIDASE, VIRAL PARTICLE, HYDROLASE
3hzc:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [GLY51;AIB51']HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR | ASYMMETRIC DIMER, COVALENT DIMER, BETA-SHEET, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1hiv:B (VAL11) to (ARG87) CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hpo:A (VAL11) to (ARG87) HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX | HYDROLASE, ACID PROTEASE, ASPARTYL PROTEASE
4m8y:B (PRO9) to (ARG88) GS-8374, A NOVEL PHOSPHONATE-CONTAINING INHIBITOR OF HIV-1 PROTEASE, EFFECTIVELY INHIBITS HIV PR MUTANTS WITH AMINO ACID INSERTIONS | HIV-1 PROTEASE, ASPARTIC PROTEASE, AMINO ACID INSERTION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1mer:B (PRO9) to (ARG87) HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
1ytg:A (ARG8) to (ARG87) SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA- DIRECTED DNA POLYMERASE, HYDROLASE-PEPTIDE COMPLEX
1zp8:A (PRO9) to (ARG87) HIV PROTEASE WITH INHIBITOR AB-2 | PROTEASE, RETROVIRAL, HYDROLASE
3nls:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH KNI-10772 | PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu3:A (GLN18) to (ARG87) WILD TYPE HIV-1 PROTEASE WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu4:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT V32I WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvj:A (VAL11) to (ARG87) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH AMPRENAVIR | HIV-1 PROTEASE-INHIBITOR COMPLEX, AMPRENAVIR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvj:C (VAL11) to (ARG87) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH AMPRENAVIR | HIV-1 PROTEASE-INHIBITOR COMPLEX, AMPRENAVIR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9c:B (ARG8) to (GLY86) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD20 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ogq:A (PRO14) to (GLY103) CRYSTAL STRUCTURE OF 6S-98S FIV PROTEASE WITH LOPINAVIR BOUND | ASPARTYL PROTEASE, HIV-LIKE FIV CHIMERA, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqh:A (GLN18) to (ARG87) CRYSTAL STRUCTURE OF (R14C/E65C) HIV-1 PROTEASE IN COMPLEX WITH DRV | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX