3rjc:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR L4-12 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3e64:A (MET865) to (ILE992) FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS | DRUG DISCOVERY, JAK2, FRAGMENT BASED, ATP-BINDING, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3rk5:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-72 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rk7:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-71 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rk9:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-74 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rm6:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-2-80 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rm7:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-91 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gt3:A (GLY35) to (ILE163) ATP-BOUND FORM OF THE ERK2 KINASE | KINASE, TRANSFERASE
3e8n:A (GLY80) to (LEU206) X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) COMPLEXED WITH A POTENT INHIBITOR RDEA119 AND MGATP | PROTEIN KINASE-LIGAND-MGATP COMPLEX, RDEA119, RDEA-119, MEK1, MEK1-RDEA119 COMPLEX, ACETYLATION, ATP-BINDING, DISEASE MUTATION, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, TYROSINE-PROTEIN KINASE
3e92:A (SER37) to (ASP168) CRYSTAL STRUCTURE OF P38 KINASE IN COMPLEX WITH A BIARYL AMIDE INHIBITOR | P38, SERINE/THREONINE PROTEIN KINASE, MAP KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3rmf:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-33 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rni:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-3-86 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3roy:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-154 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rpr:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-49 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rpv:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-88 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rpy:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-40 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2oic:A (GLY198) to (SER328) CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH STAUROSPORINE | KINASE, TRANSFERASE
2oic:C (GLY198) to (SER328) CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH STAUROSPORINE | KINASE, TRANSFERASE
2ojg:A (GLY35) to (ILE163) CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH N,N-DIMETHYL-4-(4- PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE | KINASE INHIBITOR, TRANSFERASE
2oji:A (GLY35) to (ILE163) CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH N-BENZYL-4-(4-(3- CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE | KINASE INHIBITOR, TRANSFERASE
2okr:D (SER37) to (ILE166) CRYSTAL STRUCTURE OF THE P38A-MAPKAP KINASE 2 HETERODIMER | KINASE, NLS, NES, HETERODIMER, DOCKING GROOVE, TRANSFERASE
2onl:A (SER37) to (ALA172) CRYSTAL STRUCTURE OF THE P38A-MAPKAP KINASE 2 HETERODIMER | HETERODIMER, KINASE, NLS, NES, DOCKING GROOVE, TRANSFERASE
4h39:A (GLY76) to (ASP207) CRYSTAL STRUCTURE OF JNK3 IN COMPLEX WITH JIP1 PEPTIDE | MAPK, KINASE, TRANSFERASE
4h3b:C (GLY76) to (ASP207) CRYSTAL STRUCTURE OF JNK3 IN COMPLEX WITH SAB PEPTIDE | SH3BP-5, MAPK, KINASE, TRANSFERASE
4h3p:D (GLY37) to (ILE165) CRYSTAL STRUCTURE OF HUMAN ERK2 COMPLEXED WITH A MAPK DOCKING PEPTIDE | KINASE DOMAIN, SIGNALING, LINEAR MOTIF, SURFACE MUTATION, TRANSFERASE
1aq1:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, STAUROSPORINE, CELL DIVISION, MITOSIS, INHIBITION
2b52:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH DPH- 042562 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE
2b54:A (LYS20) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 (CKD2)COMPLEXED WITH DIN- 232305 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE
3elj:A (GLY38) to (ASP169) JNK1 COMPLEXED WITH A BIS-ANILINO-PYRROLOPYRIMIDINE INHIBITOR. | C-JUN N-TERMINAL KINASE, MITOGEN-ACTIVATED PROTEIN KINASE, ATP- BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, JNK1
3s1h:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-39 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2bal:A (GLY36) to (ASP168) P38ALPHA MAP KINASE BOUND TO PYRAZOLOAMINE | P38, MAP KINASE, SERINE/THREONINE KINASE, TRANSFERASE
2p33:A (GLY76) to (ASP207) SYNTHESIS AND SAR OF AMINOPYRIMIDINES AS NOVEL C-JUN N- TERMINAL KINASE (JNK) INHIBITORS | JNK3 KINASE, INHIBITOR, TRANSFERASE
4x21:A (ILE77) to (ASP207) THE MAP KINASE JNK3 AS TARGET FOR HALOGEN BONDING | MAPK, HALOGEN BOND COMPLEX, TRANSFERASE
4x3f:A (GLY25) to (ASP159) CRYSTAL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THE M. TUBERCULOSIS SER/THR KINASE PKNA | KINASE, AUTOINHIBITION, PHOSPHORYLATION, TRANSFERASE
4x3f:B (GLY25) to (ASP159) CRYSTAL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THE M. TUBERCULOSIS SER/THR KINASE PKNA | KINASE, AUTOINHIBITION, PHOSPHORYLATION, TRANSFERASE
4x3f:C (GLY25) to (THR158) CRYSTAL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THE M. TUBERCULOSIS SER/THR KINASE PKNA | KINASE, AUTOINHIBITION, PHOSPHORYLATION, TRANSFERASE
1bl7:A (GLY36) to (ILE166) THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025 | TRANSFERASE, INHIBITOR, MAP KINASE, SERINE/ THREONINE- PROTEIN KINASE, P38
1bmk:A (SER37) to (ILE166) THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655 | TRANSFERASE, INHIBITORS, MAP KINASE, SERINE/ THREONINE- PROTEIN KINASE, P38
3f66:B (HIS1094) to (VAL1220) HUMAN C-MET KINASE IN COMPLEX WITH QUINOXALINE INHIBITOR | C-MET, PROTEIN KINASE, QUINOXALINE, ALTERNATIVE SPLICING; ATP-BINDING; CHROMOSOMAL REARRANGEMENT; DISEASE MUTATION; GLYCOPROTEIN; KINASE; MEMBRANE; NUCLEOTIDE-BINDING; PHOSPHOPROTEIN; POLYMORPHISM; PROTO-ONCOGENE; RECEPTOR; REPEAT; SIGNAL; TRANSFERASE; TRANSMEMBRANE; TYROSINE- PROTEIN KINASE.
4x7j:A (GLY605) to (GLY954) CO-CRYSTAL STRUCTURE OF PERK WITH 2-AMINO-N-[4-METHOXY-3- (TRIFLUOROMETHYL)PHENYL]-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6- YL]BENZAMIDE INHIBITOR | CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR, COMPLEX
4x7k:A (GLY605) to (GLY954) CO-CRYSTAL STRUCTURE OF PERK BOUND TO 4-{2-AMINO-3-[5-FLUORO-2- (METHYLAMINO)QUINAZOLIN-6-YL]-4-METHYLBENZOYL}-1-METHYL-2,5-DIPHENYL- 1,2-DIHYDRO-3H-PYRAZOL-3-ONE INHIBITOR | CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR, COMPLEX
4x7l:A (GLY605) to (GLY954) CO-CRYSTAL STRUCTURE OF PERK BOUND TO 4-{2-AMINO-4-METHYL-3-[2- (METHYLAMINO)-1,3-BENZOTHIAZOL-6-YL]BENZOYL}-1-METHYL-2,5-DIPHENYL-1, 2-DIHYDRO-3H-PYRAZOL-3-ONE INHIBITOR | CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR, COMPLEX
1o9u:A (GLY68) to (LEU198) GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE | TRANSFERASE-TRANSFERASE SUBSTRATE COMPLEX, KINASE, INSULIN PATHWAY, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, MULTIGENE FAMILY, PHOSPHORYLATION, DEVELOPMENTAL PROTEIN, ANTI-ONCOGENE, APOPTOSIS, TRANSFERASE- TRANSFERASE SUBSTRATE COMPLEX
1ob3:A (GLY16) to (ASP143) STRUCTURE OF P. FALCIPARUM PFPK5 | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, CDK
1ob3:B (GLY16) to (ASP143) STRUCTURE OF P. FALCIPARUM PFPK5 | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, CDK
2pvl:A (SER51) to (LEU173) STRUCTURE-BASED DESIGN OF PYRAZOLO[1,5-A][1,3,5]TRIAZINE DERIVATIVES AS POTENT INHIBITORS OF PROTEIN KINASE CK2 | STRUCTURE-BASED DRUG DESIGN, ENZYME-INHIBITOR COMPLEX, CASEIN KINASE II, PROTEIN KINASE CK2, TRANSFERASE
4i5h:A (GLY35) to (ILE163) CRYSTAL STRUCTURE OF A DOUBLE MUTANT RAT ERK2 COMPLEXED WITH A TYPE II QUINAZOLINE INHIBITOR | MAP KINASE, DFG-OUT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3sls:A (GLY80) to (LEU206) CRYSTAL STRUCTURE OF HUMAN MEK-1 KINASE IN COMPLEX WITH UCB1353770 AND AMPPNP | SERINE-THREONINE KINASE, SIGNALLING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3sls:B (LYS84) to (LEU206) CRYSTAL STRUCTURE OF HUMAN MEK-1 KINASE IN COMPLEX WITH UCB1353770 AND AMPPNP | SERINE-THREONINE KINASE, SIGNALLING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1opj:B (GLU274) to (VAL398) STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE | TRANSFERASE
1cm8:A (ALA40) to (ILE169) PHOSPHORYLATED MAP KINASE P38-GAMMA | P38-GAMMA, GAMMA, PHOSPHORYLATION, MAP KINASE, TRANSFERASE
1cm8:B (ALA1040) to (ILE1169) PHOSPHORYLATED MAP KINASE P38-GAMMA | P38-GAMMA, GAMMA, PHOSPHORYLATION, MAP KINASE, TRANSFERASE
4xmo:A (GLY1090) to (VAL1220) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH (R)-5-(8-FLUORO-3-(1- FLUORO-1-(3-METHOXYQUINOLIN-6-YL)ETHYL)-[1,2,4]TRIAZOLO[4,3- A]PYRIDIN-6-YL)-3-METHYLISOXAZOLE | RECEPTOR TYROSINE KINASE, INTRACELLULAR CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3sw4:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF THE CDK2 IN COMPLEX WITH THIAZOLYLPYRIMIDINE INHIBITOR | ALPHA AND BETA PROTEIN (A+B), TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3sw7:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF THE CDK2 IN COMPLEX WITH THIAZOLYLPYRIMIDINE INHIBITOR | ALPHA AND BETA PROTEIN (A+B), TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2cch:A (GLY16) to (LEU143) THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA- LINKED ATP ANALOGUE | COMPLEX(TRANSFERASE/CELL DIVISION), ATP-BINDING, CDK2, CELL CYCLE, CELL DIVISION, CYCLIN, MITOSIS, NUCLEAR PROTEIN, PEPTIDE SPECIFICITY, PHOSPHORYLATION, POLYMORPHISM, PROTEIN KINASE, RECRUITMENT, SERINE-THREONINE-PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3g0f:A (ALA616) to (ILE808) KIT KINASE DOMAIN MUTANT D816H IN COMPLEX WITH SUNITINIB | KIT KINASE DOMAIN, SUTENT BINDING, DRUG RESISTANCE, ATP- BINDING, DISEASE MUTATION, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE
2qc6:A (GLU55) to (LEU173) PROTEIN KINASE CK2 IN COMPLEX WITH DBC | CK2, DBC, KINASE INHIBITORS, COUMARINS, TRANSFERASE
1daw:A (GLU55) to (LEU173) CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP | PROTEIN KINASE CK2, DUAL-COSUBSTRATE SPECIFICITY, BINARY COMPLEX, TRANSFERASE
1day:A (GLU55) to (LEU173) CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP | PROTEIN KINASE CK2, DUAL-COSUBSTRATE SPECIFICITY, BINARY COMPLEX WITH MG-GMPPNP, TRANSFERASE
1pf8:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH A NUCLEOSIDE INHIBITOR | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION, SU9516, INHIBITOR
1di9:A (GLY36) to (ILE166) THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7- DIMETHOXYQUINAZOLINE | SERINE/THREONINE PROTEIN KINASE, MAP KINASE, P38, TRANSFERASE
3g90:X (ILE77) to (ASP207) JNK-3 BOUND TO (Z)-5-FLUORO-1-((6-FLUORO-4H-BENZO[D][1,3]DIOXIN-8-YL) METHYL)-3-(HYDROXYIMINO)INDOLIN-2-ONE | KINASE, INHIBITOR, PHOSPHORYLATION, ATP-BINDING, EPILEPSY, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3g9n:A (GLY32) to (ASP163) JNK3 BOUND TO (Z)-1-((6-FLUORO-4H-BENZO[D][1,3]DIOXIN-8-YL)METHYL)-3- (HYDROXYIMINO)-4-PHENYLINDOLIN-2-ONE | KINASE, INHIBITOR, PHOSPHORYLATION, ATP-BINDING, EPILEPSY, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3gcq:A (GLY36) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH RL45 | DFG-OUT, TYPE II, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1pkd:A (GLY16) to (LEU143) THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO- CDK2/CYCLIN A | PROTEIN KINASE-DRUG COMPLEX, TRANSFERASE/CELL CYCLE COMPLEX
4iti:A (LYS30) to (ASP156) CRYSTAL STRUCTURE OF RIP1 KINASE IN COMPLEX WITH NECROSTATIN-3 ANALOG | ALPHA/BETA, RIP1 KINASE, NECROPTOSIS, NECROSTATINS, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3gfe:A (SER37) to (ASP168) CRYSTAL STRUCTURE OF P38A MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH A PYRAZOLOPYRIDINONE INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM
1pme:A (GLY37) to (ILE165) STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE | MAP KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
4xyf:A (GLY1090) to (VAL1220) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH (S)-5-(8-FLUORO-3-(1-(3-(2- METHOXYETHOXY)QUINOLIN-6-YL)ETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6- YL)-3-METHYLISOXAZOLE | RECEPTOR TYROSINE KINASE, INHIBITOR, COMPLEX, INTRACELLULAR CATALYTIC DOMAIN
3gi3:A (SER37) to (ILE166) CRYSTAL STRUCTURE OF A N-PHENYL-N'-NAPHTHYLUREA ANALOG IN COMPLEX WITH P38 MAP KINASE | TWO LOBE KINASE STRUCTURE, N-LOBE BETA-SHEET, C-LOBE ALPHA- HELIX, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3gql:A (ASN506) to (ASP641) CRYSTAL STRUCTURE OF ACTIVATED RECEPTOR TYROSINE KINASE IN COMPLEX WITH SUBSTRATES | PHOSPHORYLATED KINASE, ACTIVATION, ATP ANALOG, ATP-BINDING, CRANIOSYNOSTOSIS, DISEASE MUTATION, DISULFIDE BOND, DWARFISM, GLYCOPROTEIN, HEPARIN-BINDING, HYPOGONADOTROPIC HYPOGONADISM, IMMUNOGLOBULIN DOMAIN, KALLMANN SYNDROME, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1pxl:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]- (4-TRIFLUOROMETHYL-PHENYL)-AMINE | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.
1pxm:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2- YLAMINO]-PHENOL | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.
1pxp:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]- N',N'-DIMETHYL-BENZENE-1,4-DIAMINE | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.
3gt8:D (LYS713) to (ILE829) CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP | INACTIVE KINASE, DIMER, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, CELL MEMBRANE, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, ISOPEPTIDE BOND, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, UBL CONJUGATION
4y73:B (GLY198) to (ILE327) CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN WITH INHIBITOR | KINASE, INHIBITOR
3tg1:A (GLY36) to (ILE166) CRYSTAL STRUCTURE OF P38ALPHA IN COMPLEX WITH A MAPK DOCKING PARTNER | KINASE/RHODANESE-LIKE DOMAIN, DOCKING INTERACTION, TRANSFERASE- HYDROLASE COMPLEX
1e9h:C (TYR15) to (LEU143) THR 160 PHOSPHORYLATED CDK2 - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR INDIRUBIN-5-SULPHONATE BOUND | CELL CYCLE, COMPLEX (PROTEIN KINASE/CYCLIN), KINASES, INHIBITOR, CYCLIN, COMPLEX, PHOSPHORYLATION
3tiy:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH NSC 35676 | PROTEIN KINASE, ALLOSTERIC LIGAND, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tiz:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH NSC 111848 | PROTEIN KINASE, ALLOSTERIC LIGAND, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tt0:B (ALA495) to (ASP641) CO-STRUCTURE OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE DOMAIN WITH 3-(2,6-DICHLORO-3,5-DIMETHOXY-PHENYL)-1-{6-[4-(4-ETHYL-PIPERAZIN-1- YL)-PHENYLAMINO]-PYRIMIDIN-4-YL}-1-METHYL-UREA (BGJ398) | KINASE DOMAIN, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tv6:B (LYS473) to (GLY593) HUMAN B-RAF KINASE DOMAIN IN COMPLEX WITH A METHOXYPYRAZOLOPYRIDINYL BENZAMIDE INHIBITOR | B-RAF, KINASE, KINASE INHIBITOR, TRANSFERASE, C-RAF, RAS, MEK, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4joa:A (GLU1132) to (ILE1268) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 7-AZAINDOLE BASED INHIBITOR | ANAPLASTIC LYMPHOMA KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3u4w:A (GLY279) to (VAL402) SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC4B | PROTEIN KINASE, SRC-LIKE INACTIVE CONFORMATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3hec:A (SER37) to (LEU167) P38 IN COMPLEX WITH IMATINIB | TRANSFERASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE
1r39:A (GLY36) to (ILE166) THE STRUCTURE OF P38ALPHA | SERINE/THREONINE KINASE, MUTAGENESIS, STABILIZATION, TRANSFERASE
4yp8:B (GLY198) to (SER328) IRAK4-INHIBITOR CO-STRUCTURE | KINASE, PHOSPHATASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yr8:F (GLY38) to (ASP169) CRYSTAL STRUCTURE OF JNK IN COMPLEX WITH A REGULATOR PROTEIN | KINASE DOMAIN, CATALYTIC DOMAIN, TRANSFERASE-HYDROLASE COMPLEX
4ysj:A (GLY40) to (ILE171) CALCIUM-DEPENDENT PROTEIN KINASE FROM EIMERIA TENELLA IN COMPLEX WITH ADP | SERINE/THREONINE PROTEIN KINASE, TRANSFERASE, CALCIUM-BINDING, ATP- BINDING
4ysj:B (GLY40) to (ILE170) CALCIUM-DEPENDENT PROTEIN KINASE FROM EIMERIA TENELLA IN COMPLEX WITH ADP | SERINE/THREONINE PROTEIN KINASE, TRANSFERASE, CALCIUM-BINDING, ATP- BINDING
3ugc:A (GLY861) to (ILE992) STRUCTURAL BASIS OF JAK2 INHIBITION BY THE TYPE II INHIBTOR NVP-BBT594 | SMALL MOLECULE INHIBITOR, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ytc:A (GLY861) to (ILE992) DISCOVERY OF VX-509 (DECERNOTINIB): A POTENT AND SELECTIVE JANUS KINASE (JAK) 3 INHIBITOR FOR THE TREATMENT OF AUTOIMMUNE DISEASE | JANUS KINASE, KINASE, INHIBITOR, AUTOIMMUNE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yuq:A (GLU41) to (ILE170) CDPK1 FROM EIMERIA TENELLA IN COMPLEX WITH INHIBITOR UW1354 | SERINE/THREONINE PROTEIN KINASE, TRANSFERASE, CALCIUM-BINDING, ATP- BINDING, BUMPED KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yuq:B (GLU41) to (ILE170) CDPK1 FROM EIMERIA TENELLA IN COMPLEX WITH INHIBITOR UW1354 | SERINE/THREONINE PROTEIN KINASE, TRANSFERASE, CALCIUM-BINDING, ATP- BINDING, BUMPED KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ka3:A (GLY36) to (LEU167) STRUCTURE OF MAP KINASE IN COMPLEX WITH A DOCKING PEPTIDE | KINASE DOMAIN, PHOSPHORYLATION, KIM, TRANSFERASE-PROTEIN BINDING COMPLEX
3uli:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) BOUND TO AZABENZIMIDAZOLE DERIVATIVE | AZABENZIMIDAZOLE DERIVATIVE, PHOSPHOTRANSFER, COMPLEX WITH CYCLIN A OR CYCLIN E, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yzb:A (ILE43) to (ILE171) CDPK1 FROM EIMERIA TENELLA IN COMPLEX WITH INHIBITOR UW1521 | SERINE/THREONINE PROTEIN KINASE, TRANSFERASE, CALCIUM-BINDING, ATP- BINDING, BUMPED KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3hng:A (ALA844) to (LEU1043) CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITH N-(4-CHLOROPHENYL)-2- ((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDE | RECEPTOR TYROSINE KINASE, VEGFR1,FLT1,KINASE DOMAIN,INHIBITOR, ACTIVATION LOOP,VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, STRUCTURAL GENOMICS,STRUCTURAL GENOMICS CONSORTIUM,SGC,SGC STOCKHOLM, ANGIOGENESIS, ATP-BINDING, CELL MEMBRANE, DEVELOPMENTAL PROTEIN, DIFFERENTIATION, DISULFIDE BOND, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3unk:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR YL5-083 | PROTEIN KINASE, ALLOSTERIC LIGAND, ANS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1g5s:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717 | PROTEIN-INHIBITOR COMPLEX, CELL CYCLE/TRANSFERASE COMPLEX
4kin:B (GLY36) to (ASP168) CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE 14 (P38-H5) COMPLEX WITH 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2- METHYLPHENYL)-2-THIOPHENECARBOXAMIDE | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4kin:D (SER37) to (ASP168) CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE 14 (P38-H5) COMPLEX WITH 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2- METHYLPHENYL)-2-THIOPHENECARBOXAMIDE | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4kiq:A (GLY36) to (ASP168) CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE 14 (P38-H5) COMPLEX WITH ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL) CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3hv5:B (GLY36) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH RL24 | DFG-OUT, TYPE II, RL24, QUINOLINE-PYRAZOLOUREA, HYBRID, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1gii:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR | PROTEIN KINASE, CELL CYCLE, INHIBITION, TRANSFERASE
4knb:C (GLY1090) to (ALA1221) C-MET IN COMPLEX WITH OSI LIGAND | PROTEIN KINASE, TRANSFERASE
2fvd:A (GLY16) to (LEU143) CYCLIN DEPENDENT KINASE 2 (CDK2) WITH DIAMINOPYRIMIDINE INHIBITOR | CDK2 LIGAND, TRANSFERASE
3hzt:A (GLY88) to (ILE218) CRYSTAL STRUCTURE OF TOXOPLASMA GONDII CDPK3, TGME49_105860 | CALCIUM DEPENDENT KINASE, CALMODULIN, TROPONIN PARASITE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3v6s:A (ILE77) to (ASP207) DISCOVERY OF POTENT AND SELECTIVE COVALENT INHIBITORS OF JNK | KINASE FOLD, APOPTOSIS, MAP KINASE, CYS MODIFICATION, JNK, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3v6s:B (GLY76) to (ASP207) DISCOVERY OF POTENT AND SELECTIVE COVALENT INHIBITORS OF JNK | KINASE FOLD, APOPTOSIS, MAP KINASE, CYS MODIFICATION, JNK, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2g2i:A (GLY254) to (VAL379) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
2g2i:B (GLU258) to (VAL379) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
2vti:A (GLY16) to (LEU143) IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6- DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT- BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN. | TRANSFERASE, MITOSIS, CELL CYCLE, SERINE/THREONINE PROTEIN KINASE
4zji:C (GLY282) to (LEU405) PAK1 IN COMPLEX WITH 2-CHLORO-5-ETHYL-8-FLUORO-11-(4-METHYLPIPERAZIN- 1-YL)-DIBENZODIAZEPINE | INHIBITOR, KINASE, PAK1, ALLOSTERIC, TRANSFERASE
4l00:A (SER599) to (ASP739) CRYSTAL STRUCTURE OF THE APO JAK1 PSEUDOKINASE DOMAIN | KINASE DOMAIN FOLD, REGULATORY, TRANSFERASE
1h1r:C (GLY16) to (GLY147) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6086 | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1h1s:A (GLY16) to (LEU143) STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6102 | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP- BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION
1h25:C (VAL17) to (LEU143) CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM RETINOBLASTOMA-ASSOCIATED PROTEIN | TRANSFERASE, CELL CYCLE, PROTEIN KINASE, CYCLIN, CDK2, RECRUITMENT, PEPTIDE SPECIFICITY
4zlo:A (GLY282) to (LEU405) SERINE/THREONINE-PROTEIN KINASE PAK1 COMPLEXED WITH A DIBENZODIAZEPINE: IDENTIFICATION OF AN ALLOSTERIC SITE ON PAK1 | DIBENZODAZEPINE, PAK1, KINASE, ALLOSTERIC INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2w5b:A (GLY20) to (ASP159) HUMAN NEK2 KINASE ATPGAMMAS-BOUND | TRANSFERASE, MEIOSIS, MITOSIS, CYTOPLASM, METAL-BINDING, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, MAGNESIUM, CELL CYCLE, ATP-BINDING, CENTROSOME SPLITTING, CELL DIVISION
2w5h:A (GLY20) to (LEU157) HUMAN NEK2 KINASE APO | SER/THR PROTEIN KINASE, KINASE, NUCLEUS, MEIOSIS, MITOSIS, CYTOPLASM, SERINE/THREONINE-PROTEIN KINASE, METAL-BINDING, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, MAGNESIUM, CELL CYCLE, ATP-BINDING, TRANSFERASE, CENTROSOME SPLITTING, ALTERNATIVE SPLICING, COILED COIL, POLYMORPHISM, CELL DIVISION
4zth:A (GLY36) to (ASP168) STRUCTURE OF HUMAN P38AMAPK-ARYLPYRIDAZINYLPYRIDINE FRAGMENT COMPLEX USED IN INHIBITOR DISCOVERY | TRANSFERASE
4lgd:C (PHE42) to (LEU162) STRUCTURAL BASIS FOR AUTOACTIVATION OF HUMAN MST2 KINASE AND ITS REGULATION BY RASSF5 | HIPPO, MST AUTOACTIVATION, RASSF, SARAH DOMAIN, DIMERIZATION, SIGNALING PROTEIN
3iph:A (GLY36) to (ASP168) CRYSTAL STRUCTURE OF P38 IN COMPLEX WITH A BIPHENYLAMIDE INHIBITOR | P38, SERINE/THREONINE PROTEIN KINASE, MAP KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3is5:B (GLY147) to (ASP281) CRYSTAL STRUCTURE OF CDPK KINASE DOMAIN FROM TOXOPLASMA GONDII, TGME49_018720 | TOXOPLASMA GONDII, CDPK, STRUCTURAL GENOMICS, PARASITOLOGY, STRUCTURAL GENOMICS CONSORTIUM, SGC, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3is5:C (PHE146) to (ILE280) CRYSTAL STRUCTURE OF CDPK KINASE DOMAIN FROM TOXOPLASMA GONDII, TGME49_018720 | TOXOPLASMA GONDII, CDPK, STRUCTURAL GENOMICS, PARASITOLOGY, STRUCTURAL GENOMICS CONSORTIUM, SGC, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3is5:F (LEU151) to (ASP281) CRYSTAL STRUCTURE OF CDPK KINASE DOMAIN FROM TOXOPLASMA GONDII, TGME49_018720 | TOXOPLASMA GONDII, CDPK, STRUCTURAL GENOMICS, PARASITOLOGY, STRUCTURAL GENOMICS CONSORTIUM, SGC, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3itz:A (SER37) to (ASP168) CRYSTAL STRUCTURE OF P38A MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH A PYRAZOLOPYRIDAZINE INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM
2wd1:A (GLY1095) to (ALA1221) HUMAN C-MET KINASE IN COMPLEX WITH AZAINDOLE INHIBITOR | HUMAN KINASE, C-MET, AZAINDOLE, INHIBITOR, TRANSFERASE, KINASE, NUCLEOTIDE-BINDING, ATP-BINDING, TYROSINE-PROTEIN KINASE
2wgj:A (HIS1094) to (ALA1221) X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET | C-MET, KINASE, INHIBITOR, TRANSFERASE, ATP-BINDING, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE
4loo:A (GLY36) to (ILE166) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (MONOCLINIC CRYSTAL FORM) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4lop:A (GLY36) to (ASP168) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4lop:B (GLY36) to (ILE166) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4lop:C (GLY36) to (ILE166) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4lop:D (GLY36) to (ASP168) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
3vug:A (GLY38) to (ILE167) CRYSTAL STRUCTURE OF A CYSTEINE-DEFICIENT MUTANT M2 IN MAP KINASE JNK1 | MAP KINASE, TRANSCRIPTION, PHOSPHORYLATION, ATP BINDING, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3vvh:A (GLY80) to (LEU206) X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN COMPLEX WITH AN INHIBITOR AND MGATP | KINASE DOMAIN, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2wma:A (VAL17) to (LEU143) STRUCTURAL AND THERMODYNAMIC CONSEQUENCES OF CYCLIZATION OF PEPTIDE LIGANDS FOR THE RECRUITMENT SITE OF CYCLIN A | CELL CYCLE, CELL DIVISION, ANTI-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, TRANSCRIPTION REGULATION, CHROMATIN REGULATOR, RECRUITMENT, TRANSCRIPTION, NUCLEUS, MITOSIS, ATP-BINDING, TRANSFERASE
2wma:C (GLY16) to (LEU143) STRUCTURAL AND THERMODYNAMIC CONSEQUENCES OF CYCLIZATION OF PEPTIDE LIGANDS FOR THE RECRUITMENT SITE OF CYCLIN A | CELL CYCLE, CELL DIVISION, ANTI-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, TRANSCRIPTION REGULATION, CHROMATIN REGULATOR, RECRUITMENT, TRANSCRIPTION, NUCLEUS, MITOSIS, ATP-BINDING, TRANSFERASE
3w2c:A (LEU149) to (ASP274) STRUCTURE OF AURORA KINASE A COMPLEXED TO BENZOIMIDAZOLE-INDAZOLE INHIBITOR XV | KINASE, ATP COMPETITOR, TRANSFERASE
3w2c:C (LEU149) to (ASP274) STRUCTURE OF AURORA KINASE A COMPLEXED TO BENZOIMIDAZOLE-INDAZOLE INHIBITOR XV | KINASE, ATP COMPETITOR, TRANSFERASE
3w2r:A (LYS737) to (ILE853) EGFR KINASE DOMAIN T790M/L858R MUTANT WITH COMPOUND 4 | ANTI-ONCOGENE, CELL CYCLE, DISEASE MUTATION, KINASE DOMAIN, RECEPTOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2hw7:A (HIS95) to (ASP226) CRYSTAL STRUCTURE OF MNK2-D228G IN COMPLEX WITH STAUROSPORINE | PROTEIN KINASES, DRUG, INHIBITOR, PHOSPHORYLATION, TRANSFERASE
1uki:A (GLY38) to (ASP169) STRUCTURAL BASIS FOR THE SELECTIVE INHIBITION OF JNK1 BY THE SCAFFOLDING PROTEIN JIP1 AND SP600125 | TRANSFERASE, PHOSPHORYLATION
5a9u:A (GLY1128) to (ILE1268) STRUCTURE OF C1156Y MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10, 16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO) PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3- CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
5aa9:A (PHE1127) to (ILE1268) STRUCTURE OF L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10, 16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO) PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3- CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR, MUTANT
5aac:A (GLY1128) to (ILE1268) STRUCTURE OF C1156Y MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
2wzj:A (LYS66) to (ASP193) CATALYTIC AND UBA DOMAIN OF KINASE MARK2/(PAR-1) K82R, T208E DOUBLE MUTANT | UBA DOMAIN, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, SIGNALING PROTEIN, S/T PROTEIN KINASE, DIFFERENTIATION, DEVELOPMENTAL PROTEIN
2wzj:E (ALA65) to (ASP193) CATALYTIC AND UBA DOMAIN OF KINASE MARK2/(PAR-1) K82R, T208E DOUBLE MUTANT | UBA DOMAIN, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, SIGNALING PROTEIN, S/T PROTEIN KINASE, DIFFERENTIATION, DEVELOPMENTAL PROTEIN
5acb:C (GLY739) to (LEU875) CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX | TRANSFERASE
5acb:D (GLY739) to (LEU875) CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX | TRANSFERASE
3wf6:A (GLN107) to (LEU234) CRYSTAL STRUCTURE OF S6K1 KINASE DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE DERIVATIVE 4-[4-(1H-INDOL-3-YL)-3,6- DIHYDROPYRIDIN-1(2H)-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDINE | SERINE/THREONINE PROTEIN KINASE DOMAIN, TRANSFERASE, PHOSPHORYLATION, ATP-BINDING, ZINC-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1v0b:A (GLY16) to (ASP143) CRYSTAL STRUCTURE OF THE T198A MUTANT OF PFPK5 | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, CDK
1v0b:B (GLY16) to (ASP143) CRYSTAL STRUCTURE OF THE T198A MUTANT OF PFPK5 | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, CDK
1v0p:A (GLY16) to (ASP143) STRUCTURE OF P. FALCIPARUM PFPK5-PURVALANOL B LIGAND COMPLEX | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, CDK
5ajq:A (GLY48) to (ASP175) HUMAN LOK (STK10) IN COMPLEX WITH BOSUTINIB | TRANSFERASE
2x7f:C (GLY37) to (VAL170) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, PHOSPHOPROTEIN, KINASE, TRANSFERASE
2itx:A (LYS737) to (ILE853) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AMP- PNP | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, ANP, EGFR, KINASE, AMP-PNP, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
1jam:A (GLU55) to (LEU173) CRYSTAL STRUCTURE OF APO-FORM OF Z. MAYS CK2 PROTEIN KINASE ALPHA SUBUNIT | PROTEIN KINASE FOLD, TRANSFERASE
4mne:E (GLY80) to (LEU206) CRYSTAL STRUCTURE OF THE BRAF:MEK1 COMPLEX | RAF, MAPK, KINASE DOMAIN, ATP-BINDING, ERK, RAS, PAK, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2xba:A (GLU1132) to (ILE1268) STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PHA-E429 | ATP-BINDING, RECEPTOR, TRANSFERASE
3wow:A (SER51) to (LEU173) CRYSTAL STRUCTURE OF HUMAN CK2A WITH AMPPNP | TYPICAL KINASE FOLD, TRANSFERASE
5ap6:A (GLN541) to (ASP664) NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. | TRANSFERASE, MPS1, MITOSIS
2j7t:A (GLY48) to (LEU173) CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274 | KINASE, TRANSFERASE, ATP-BINDING, CELL CYCLE PROGRESSION, PHOSPHORYLATION, DISEASE MUTATION, NUCLEOTIDE- BINDING, LYMPHOCYTE ORIENTED KINASE (LOK), SERINE/THREONINE- PROTEIN KINASE, SERINE/THREONINE KINASE (STK10A)
2xkd:A (GLY20) to (LEU157) STRUCTURE OF NEK2 BOUND TO AMINOPYRAZINE COMPOUND 12 | TRANSFERASE, CENTROSOME, MITOSIS
4mxc:A (GLY1095) to (VAL1220) CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH NOVEL INHIBITOR | CMET INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2j9m:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF CDK2 IN COMPLEX WITH MACROCYCLIC AMINOPYRIMIDINE | SERINE-THREONINE PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, ARYLAMINE N-ACETYLTRANSFERASE, CELL DIVISION, DRUG METABOLISM, PHOSPHORYLATION, ATP-BINDING, TRANSFERASE, MYCOBACTERIA, POLYMORPHISM, NAT, KINASE, MITOSIS, ISONIAZID, CELL CYCLE
1jwh:A (GLU55) to (LEU173) CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 HOLOENZYME | CASEIN KINASE 2, CK2 HOLOENZYME, PROTEIN KINASE CK2, TRANSFERASE
2xno:A (GLY20) to (LEU157) STRUCTURE OF NEK2 BOUND TO CCT243779 | TRANSFERASE, CENTROSOME, MITOSIS, CELL CYCLE
2xp2:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB (PF-02341066) | CRIZOTINIB, TRANSFERASE
2xs0:A (GLY38) to (ASP169) LINEAR BINDING MOTIFS FOR JNK AND FOR CALCINEURIN ANTAGONISTICALLY CONTROL THE NUCLEAR SHUTTLING OF NFAT4 | TRANSCRIPTION, TRANSFERASE, MAPK SIGNALING PATHWAYS, LINEAR BINDING MOTIFS
5b7v:A (ASN506) to (ASP641) HUMAN FGFR1 KINASE IN COMPLEX WITH CH5183284 | PROTEIN KINASE, ATP-BINDING, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5bmm:A (PHE278) to (VAL402) SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC25B | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1wbw:A (SER37) to (LEU167) IDENTIFICATION OF NOVEL P38 ALPHA MAP KINASE INHIBITORS USING FRAGMENT-BASED LEAD GENERATION. | P38, MAP KINASE, INHIBITOR STRUCTURE, ALTERNATIVE SPLICING, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
2jld:A (GLY68) to (LEU198) EXTREMELY TIGHT BINDING OF RUTHENIUM COMPLEX TO GLYCOGEN SYNTHASE KINASE 3 | WNT SIGNALING PATHWAY, SERINE/THREONINE-PROTEIN KINASE, RUTHENIUM GLYCOGEN SYNTHASE KINASE PICOMOLAR, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, KINASE, TRANSFERASE, ATP-BINDING, PHOSPHOPROTEIN
5bvd:A (GLY35) to (ILE163) TETRAHYDROPYRROLO-DIAZEPENONES AS INHIBITORS OF ERK2 KINASE | INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1wfc:A (SER37) to (LEU167) STRUCTURE OF APO, UNPHOSPHORYLATED, P38 MITOGEN ACTIVATED PROTEIN KINASE P38 (P38 MAP KINASE) THE MAMMALIAN HOMOLOGUE OF THE YEAST HOG1 PROTEIN | P38 MAP KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
4nj3:A (GLY16) to (LEU143) MODULATING THE INTERACTION BETWEEN CDK2 AND CYCLIN A WITH A QUINOLINE- BASED INHIBITOR | CELL CYCLE, INHIBITION, CYCLIN-DEPENDENT KINASE, CANCER, ATP-BINDING, CELL DIVISION,MITOSIS, NUCLEOTIDE-BINDING, PHOSPHORYLATION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2y4i:C (VAL81) to (LEU206) KSR2-MEK1 HETERODIMER | TRANSFERASE, KSR1
3zos:B (GLY622) to (ILE782) STRUCTURE OF THE DDR1 KINASE DOMAIN IN COMPLEX WITH PONATINIB | TRANSFERASE, RTK, COLLAGEN, DISCOIDIN DOMAIN
2lgc:A (SER37) to (ILE166) JOINT NMR AND X-RAY REFINEMENT REVEALS THE STRUCTURE OF A NOVEL DIBENZO[A,D]CYCLOHEPTENONE INHIBITOR/P38 MAP KINASE COMPLEX IN SOLUTION | P38 MAPK KINASE-INHIBITOR COMPLEX, HYBRID NMR/X-RAY STRUCTURE, TRANSFERASE
1koa:A (GLY5954) to (LEU6081) TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS | KINASE, TWITCHIN, INTRASTERIC REGULATION
4nst:A (GLY739) to (LEU875) CRYSTAL STRUCTURE OF HUMAN CDK12/CYCLIN K IN COMPLEX WITH ADP-ALUMINUM FLUORIDE | TRANSCRIPTION, RNA POLYMERASE II, PHOSPHORYLATION, TRANSFERASE- TRANSCRIPTION COMPLEX
2yfx:A (GLY1128) to (ILE1268) STRUCTURE OF L1196M MUTANT ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | NUCLEOTIDE-BINDING, TRANSFERASE, RECEPTOR
1ksw:A (GLY279) to (VAL402) STRUCTURE OF HUMAN C-SRC TYROSINE KINASE (THR338GLY MUTANT) IN COMPLEX WITH N6-BENZYL ADP | SH3, SH2, KINASE, BUMP HOLE, BUMP-HOLE, CHEMICAL GENETICS, ORTHOGONAL SUBSTRATE, ATP, TRANSFERASE
2yhv:A (PHE1127) to (ILE1268) STRUCTURE OF L1196M MUTANT ANAPLASTIC LYMPHOMA KINASE | TRANSFERASE, RECEPTOR
3zya:A (SER37) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH 2-AMINO-PHENYLAMINO- DIBENZOSUBERONE | TRANSFERASE, ALLOSTERIC REGULATION, PROTEIN KINASE INHIBITOR, STRUCTURE-ACTIVITY RELATIONSHIP, P38 MITOGEN-ACTIVATED PROTEIN KINASES
4o0r:B (GLY282) to (LEU405) BACK POCKET FLEXIBILITY PROVIDES GROUP-II PAK SELECTIVITY FOR TYPE 1 KINASE INHIBITORS | PAK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2no3:A (GLY38) to (ILE167) NOVEL 4-ANILINOPYRIMIDINES AS POTENT JNK1 INHIBITORS | JNK1, C-JUN N-TERMINAL KINASE, JNK1 INHIBITORS, ANILINOPYRIMIDINES JNK1 INHIBITORS, SIGNALING PROTEIN/INHIBITOR COMPLEX
4o0t:B (GLY282) to (LEU405) BACK POCKET FLEXIBILITY PROVIDES GROUP-II PAK SELECTIVITY FOR TYPE 1 KINASE INHIBITORS | PAK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4o2p:A (GLY279) to (VAL402) KINASE DOMAIN OF CSRC IN COMPLEX WITH A SUBSTITUTED PYRAZOLOPYRIMIDINE | PYRAZOLO-PYRIMIDINE LIGAND, TYPE I, DFG-IN, TYROSINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cei:A (GLY33) to (ALA172) CRYSTAL STRUCTURE OF CDK8:CYCLIN C COMPLEX WITH COMPOUND 22 | KINASE, INHIBITOR, CDK8, CYCLIN DEPENDENT KINASE, CYCLIN, TRANSCRIPTION-TRANSFERASE-INHIBITOR COMPLEX
4obo:A (GLN38) to (ASP171) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 22), 6-(3-CHLOROPHENYL) QUINAZOLIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5ci6:B (GLY75) to (ILE205) CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA MPK6 | KINASE, APOENZYME, TRANSFERASE
1lew:A (GLY36) to (LEU167) CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A | PROTEIN-PEPTIDE COMPLEX, TRANSFERASE, MAP KINASE, SERINE/THREONINE- PROTEIN KINASE, P38, MEF2A
1lez:A (GLY36) to (ALA172) CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B | PROTEIN-PEPTIDE COMPLEX, TRANSFERASE, MAP KINASE, SERINE/THREONINE- PROTEIN KINASE, P38, MKK3B
5ckw:B (TYR86) to (LEU211) CRYSTAL STRUCTURE OF LEGK4_AMPPNP KINASE | LEGIONELLA, BACTERIAL EFFECTORS, SERINE/THREONINE KINASE, TYPE IV SECRETION SYSTEM, TRANSFERASE
5ckw:A (TYR86) to (LEU211) CRYSTAL STRUCTURE OF LEGK4_AMPPNP KINASE | LEGIONELLA, BACTERIAL EFFECTORS, SERINE/THREONINE KINASE, TYPE IV SECRETION SYSTEM, TRANSFERASE
4ogr:A (GLY31) to (LEU165) CRYSTAL STRUCTURE OF P-TEFB COMPLEX WITH AFF4 AND TAT | P-TEFB, CYCLIN-DEPENDENT KINASE 9, CYCLIN FOLD, INTRINSICALLY UNSTRUCTURED AFF4, TRANSCRIPTIONAL REGULATION AT HIV PROMOTER, BINDS TAR, N-TERMINAL ACETYLATION OF TAT, TRANSFERASE-VIRAL PROTEIN COMPLEX
4ogr:I (GLU32) to (LEU165) CRYSTAL STRUCTURE OF P-TEFB COMPLEX WITH AFF4 AND TAT | P-TEFB, CYCLIN-DEPENDENT KINASE 9, CYCLIN FOLD, INTRINSICALLY UNSTRUCTURED AFF4, TRANSCRIPTIONAL REGULATION AT HIV PROMOTER, BINDS TAR, N-TERMINAL ACETYLATION OF TAT, TRANSFERASE-VIRAL PROTEIN COMPLEX
5cnn:B (LYS713) to (ILE829) CRYSTAL STRUCTURE OF THE EGFR KINASE DOMAIN MUTANT I682Q | KINASE EGFR, TRANSFERASE
1lp4:A (SER51) to (LEU173) CRYSTAL STRUCTURE OF A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 WITH MG-AMPPNP | PROTEIN KINASE, CK2, CASEIN KINASE 2, DUAL-COSUBSTRATE SPECIFICITY, TRANSFERASE
1luf:A (ALA591) to (ILE740) CRYSTAL STRUCTURE OF THE MUSK TYROSINE KINASE: INSIGHTS INTO RECEPTOR AUTOREGULATION | PHOSPHORYLATION, SIGNAL TRANSDUCTION, MASS SPECTROMETRY, TRANSFERASE
2zaz:A (SER37) to (ILE166) CRYSTAL STRUCTURE OF P38 IN COMPLEX WITH 4-ANILINO QUINOLINE INHIBITOR | SERINE/THREONINE PROTEIN KINASE, MAP KINASE, P38, ATP-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHORYLATION, TRANSFERASE
2zb1:A (SER37) to (ILE166) CRYSTAL STRUCTURE OF P38 IN COMPLEX WITH BIPHENYL AMIDE INHIBITOR | SERINE/THREONINE PROTEIN KINASE, MAP KINASE, P38, ATP-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHORYLATION, TRANSFERASE
2zdt:A (GLY76) to (ASP207) CRYSTAL STRUCTURE OF HUMAN JNK3 COMPLEXED WITH AN ISOQUINOLONE INHIBITOR | PROTEIN KINASE, ATP-BINDING, EPILEPSY, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4or5:F (GLU32) to (LEU165) CRYSTAL STRUCTURE OF HIV-1 TAT COMPLEXED WITH HUMAN P-TEFB AND AFF4 | CDK9, TAT, AFF4, ZINC FINGER, TRANSCRIPTION, RNA BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSCRIPTION COMPLEX
1m7q:A (GLY36) to (ILE166) CRYSTAL STRUCTURE OF P38 MAP KINASE IN COMPLEX WITH A DIHYDROQUINAZOLINONE INHIBITOR | SERINE/THREONINE KINASE, ATP-BINDING DOMAIN, INHIBITOR, TRANSFERASE
2zoq:B (MET55) to (ILE182) STRUCTURAL DISSECTION OF HUMAN MITOGEN-ACTIVATED KINASE ERK1 | SERINE/THREONINE KINASE, ERK1, ACETYLATION, ATP-BINDING, CELL CYCLE, HOST-VIRUS INTERACTION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4acg:A (GLY68) to (LEU198) GSK3B IN COMPLEX WITH INHIBITOR | TRANSFERASE
3kq7:A (GLY36) to (ILE166) STRUCTURE OF HUMAN P38ALPHA WITH N-[4-METHYL-3-(6-{[2-(1- METHYLPYRROLIDIN-2-YL)ETHYL]AMINO}PYRIDINE-3-AMIDO)PHENYL]- 2-(MORPHOLIN-4-YL)PYRIDINE-4-CARBOXAMIDE | P38ALPHA KINASE, ALTERNATIVE SPLICING, ATP BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4p90:B (GLY282) to (LEU405) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN PAK1 IN COMPLEX WITH COMPOUND 15 | INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3kul:A (GLY652) to (VAL776) KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 8 (EPHA8) | ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, RECEPTOR, TRANSFERASE, PHOSPHORYLATION, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, STRUCTURAL GENOMICS CONSORTIUM, SGC, GLYCOPROTEIN, MEMBRANE, PHOSPHOPROTEIN
5dbx:A (ALA87) to (ILE220) CRYSTAL STRUCTURE OF MURINE SPAK(T243D) IN COMPLEX WITH AMPPNP | KINASE, TRANSFERASE
5dg5:B (HIS1094) to (ALA1221) CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP- 4157 | TYROSINE KINASE DOMAIN, HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET, C- MET, ALTIRATINIB ANALOG, DP-4157, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3l8s:A (GLY36) to (ASP168) HUMAN P38 MAP KINASE IN COMPLEX WITH CP-547632 | DFG-OUT, GLYCINE-RICH LOOP, CP-547632, ALTERNATIVE SPLICING, ATP- BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3lct:A (GLU1132) to (ILE1268) CRYSTAL STRUCTURE OF THE ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | KINASE CATALYTIC DOMAIN, ATP-BINDING, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE
3lfb:A (SER37) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH RL98 | THIAZOLE-UREA, DFG-OUT, SAR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3lff:A (GLY36) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH RL166 | THIAZOLE-UREA, DFG-OUT, SAR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3lfn:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF CDK2 WITH SAR57, AN AMINOINDAZOLE TYPE INHIBITOR | PROTEIN KINASE FOLD, ACETYLATION, ATP-BINDING, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3alo:A (GLY114) to (LEU245) CRYSTAL STRUCTURE OF HUMAN NON-PHOSPHORYLATED MKK4 KINASE DOMAIN TERNARY COMPLEX WITH AMP-PNP AND P38 PEPTIDE | KINASE, ALLOSTERIC BINDING, ACTIVATION HELIX, TRANSFERASE
4anl:A (PHE1127) to (ILE1268) STRUCTURE OF G1269A MUTANT ANAPLASTIC LYMPHOMA KINASE | TRANSFERASE, CRIZOTINIB
4ans:A (PHE1127) to (ILE1268) STRUCTURE OF L1196M,G1269A DOUBLE MUTANT ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE
5drb:A (PHE232) to (ILE366) CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH WNK463 | KINASE, INHIBITOR, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3lhj:A (SER37) to (ASP168) CRYSTAL STRUCTURE OF P38A MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH A PYRAZOLOPYRIDINONE INHIBITOR. | SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM
4ap7:A (LYS1103) to (ALA1221) CRYSTAL STRUCTURE OF C-MET KINASE DOMAIN IN COMPLEX WITH 4-( (6-(4- FLUOROPHENYL)-(1,2,4)TRIAZOLO(4,3-B)(1,2,4)TRIAZIN-3-YL)METHYL) PHENOL | TRANSFERASE
4ase:A (ALA851) to (ILE1044) CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951) | TRANSFERASE, ANGIOGENESIS, SIGNALING PROTEIN, PHOSPHORYLATION, RECEPTOR, INHIBITOR
1zoe:A (SER51) to (LEU173) CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB- DERIVATIVES INHIBITORS | PROTEIN KINASE, INHIBITOR, COMPLEX, TRANSFERASE
3lq5:A (GLY31) to (LEU165) STRUCTURE OF CDK9/CYCLINT IN COMPLEX WITH S-CR8 | TRANSCRIPTIONAL CDK-CYCLIN COMPLEX, PHOSPHORYLATED, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION REGULATION, TRANSFERASE, CELL CYCLE, CELL DIVISION, HOST-VIRUS INTERACTION,, TRANSCRIPTION-INHIBITOR COMPLEX
5efq:A (GLY717) to (LEU853) CRYSTAL STRUCTURE OF HUMAN CDK13/CYCLIN K IN COMPLEX WITH ADP-ALUMINUM FLUORIDE | KINASE, CYCLIN, ADP, TRANSFERASE
5efq:C (GLY717) to (LEU853) CRYSTAL STRUCTURE OF HUMAN CDK13/CYCLIN K IN COMPLEX WITH ADP-ALUMINUM FLUORIDE | KINASE, CYCLIN, ADP, TRANSFERASE
2ac3:A (HIS95) to (ASP226) STRUCTURE OF HUMAN MNK2 KINASE DOMAIN | DFD MOTIF, TRANSFERASE
2ac5:A (HIS95) to (ASP226) STRUCTURE OF HUMAN MNK2 KINASE DOMAIN MUTANT D228G | DFG MOTIF, TRANSFERASE
4bbm:A (GLY16) to (ASP144) CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312 | TRANSFERASE, PHOSPHO-MIMETIC
3b8q:B (GLN847) to (ILE1044) CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A NAPHTHAMIDE INHIBITOR | RECEPTOR TYROSINE KINASE, ANGIOGENESIS, ATP-BINDING, DEVELOPMENTAL PROTEIN, DIFFERENTIATION, GLYCOPROTEIN, HOST- VIRUS INTERACTION, IMMUNOGLOBULIN DOMAIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
4bcg:A (GLY31) to (LEU165) STRUCTURE OF CDK9 IN COMPLEX WITH CYCLIN T AND A 2-AMINO-4- HETEROARYL-PYRIMIDINE INHIBITOR | TRANSFERASE-CELL CYCLE COMPLEX, CDK-CYCLIN COMPLEX, TRANSCRIPTION-PROTEIN BINDING, STRUCTURE-BASED DRUG DESIGN
4qny:A (GLY33) to (ILE165) CRYSTAL STRUCTURE OF MAPK FROM LEISHMANIA DONOVANI, LDBPK_331470 | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, LEISHMANIA, KINASE, TRANSFERASE
4bcq:A (VAL17) to (LYS142) STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4- HETEROARYL-PYRIMIDINE INHIBITOR | TRANSFERASE-CELL CYCLE COMPLEX, CDK-CYCLIN COMPLEX, CYCLIN A, CYCLIN- DEPENDENT KINASE 2, STRUCTURE-BASED DRUG DESIGN
3mh0:A (SER37) to (ASP168) MUTAGENESIS OF P38 MAP KINASE ESHTABLISHES KEY ROLES OF PHE169 IN FUNCTION AND STRUCTURAL DYNAMICS AND REVEALS A NOVEL DFG-OUT STATE | SIGNALING PROTEIN,TRANSFERASE, TRANSFERASE
3mh3:A (GLY36) to (ASP168) MUTAGENESIS OF P38 MAP KINASE ESTABLISHES KEY ROLES OF PHE169 IN FUNCTION AND STRUCTURAL DYNAMICS AND REVEALS A NOVEL DFG-OUT STATE | SIGNALING PROTEIN, TRANSFERASE
4qqj:A (GLN496) to (ASP630) CRYSTAL STRUCTURE OF FGF RECEPTOR (FGFR) 4 KINASE DOMAIN HARBORING THE V550L GATE-KEEPER MUTATION | KINASE DOMAIN FOLD, CELL SIGNALING, PHOSPHOTRANSFERASE, PLASMAMEMBRANE, TRANSFERASE
5eob:A (LYS1103) to (VAL1220) CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH NOVEL INHIBITOR | CMET INHIBITOR, TRANSFERASE
4bi2:A (SER537) to (ASP664) SCAFFOLD FOCUSED VIRTUAL SCREENING: PROSPECTIVE APPLICATION TO THE DISCOVERY OF TTK INHIBITOR | TRANSFERASE, MITOSIS
5eta:B (SER37) to (ILE166) STRUCTURE OF MAPK14 WITH BOUND THE KIM DOMAIN OF THE TOXOPLASMA PROTEIN GRA24 | MAPK14, GRA24, KIM DOMAIN, PEPTIDE-PROTEIN COMPLEX, TRANSFERASE
5eta:A (SER37) to (ILE166) STRUCTURE OF MAPK14 WITH BOUND THE KIM DOMAIN OF THE TOXOPLASMA PROTEIN GRA24 | MAPK14, GRA24, KIM DOMAIN, PEPTIDE-PROTEIN COMPLEX, TRANSFERASE
3mss:B (GLU255) to (VAL379) ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3mss:C (GLU255) to (VAL379) ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3blh:A (GLY31) to (LEU165) CRYSTAL STRUCTURE OF HUMAN CDK9/CYCLINT1 | TRANSCRIPTIONAL CDK/CYCLIN COMPLEX, PHOSPHORYLATED, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION REGULATION, TRANSFERASE, ACETYLATION, CELL CYCLE, CELL DIVISION, COILED COIL, HOST-VIRUS INTERACTION
3blr:A (GLY31) to (LEU165) CRYSTAL STRUCTURE OF HUMAN CDK9/CYCLINT1 IN COMPLEX WITH FLAVOPIRIDOL | TRANSCRIPTIONAL CDK/CYCLIN COMPLEX, PHOSPHORYLATED, FLAVOPIRIDOL, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION REGULATION, TRANSFERASE, ACETYLATION, CELL CYCLE, CELL DIVISION, COILED COIL, HOST-VIRUS INTERACTION
5eyd:A (GLY1090) to (VAL1220) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH AMG 337 | PHOSPHOTRANSFERASE, INHIBITOR, CANCER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3mvl:A (ALA41) to (ASP168) P38 ALPHA MAP KINASE COMPLEXED WITH PYRROLOTRIAZINE INHIBITOR 7K | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE
3mvl:B (SER37) to (ASP168) P38 ALPHA MAP KINASE COMPLEXED WITH PYRROLOTRIAZINE INHIBITOR 7K | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE
3mvm:A (SER37) to (ASP168) P38 ALPHA MAP KINASE COMPLEXED WITH PYRROLOTRIAZINE INHIBITOR 7V | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3mvm:B (SER37) to (ASP168) P38 ALPHA MAP KINASE COMPLEXED WITH PYRROLOTRIAZINE INHIBITOR 7V | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3bv2:A (TYR35) to (ILE166) MORPHOLINO PYRROLOTRIAZINE P38 ALPHA MAP KINASE INHIBITOR COMPOUND 30 | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN
5f95:A (GLY68) to (LEU198) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH COMPOUND 18: 2- [(CYCLOPROPYLCARBONYL)AMINO]-N-(4-PHENYLPYRIDIN-3-YL)PYRIDINE-4- CARBOXAMIDE | GSK3B, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4btf:A (SER204) to (ALA335) STRUCTURE OF MLKL | TRANSFERASE, PSEDUOKINASE, NECROPTOSIS
3bx5:A (SER37) to (ILE166) P38 ALPHA MAP KINASE COMPLEXED WITH BMS-640994 | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, SIGNALING PROTEIN
4r1y:A (GLY1090) to (VAL1220) IDENTIFICATION AND OPTIMIZATION OF PYRIDAZINONES AS POTENT AND SELECTIVE C-MET KINASE INHIBITOR | TRANSFERASE INHIBITOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5fdp:A (GLY622) to (ILE782) STRUCTURE OF DDR1 RECEPTOR TYROSINE KINASE IN COMPLEX WITH D2099 INHIBITOR AT 2.25 ANGSTROMS RESOLUTION. | TRANSFERASE, DDR1 KINASE, INHIBITORS, STRUCTURAL GENOMICS, PSI- BIOLOGY, STRUCTURAL GENOMICS CONSORTIUM, SGC
4bwx:B (PRO284) to (LEU423) STRUCTURE OF NEUROSPORA CRASSA PAN3 PSEUDOKINASE MUTANT | GENE REGULATION, DEADENYLASE, PAN2, MIRNA, MRNA DECAY
4r3c:A (SER37) to (ILE166) CRYSTAL STRUCTURE OF P38 ALPHA MAP KINASE IN COMPLEX WITH A NOVEL ISOFORM SELECTIVE DRUG CANDIDATE | SERINE/THREONINE-PROTEIN KINASE, PROTEIN KINASE DOMAIN, TRANSFERASE, ATP BINDING, PHOSPHORYLATION, CYTOSOL, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4r5y:B (GLY469) to (GLY593) THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR | KINASE, SIGNAL TRANSDUCTION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4bzd:A (GLY16) to (LEU143) STRUCTURE OF CDK2 IN COMPLEX WITH A BENZIMIDAZOPYRIMIDINE | TRANSFERASE, KINASE INHIBITOR
3cgo:A (ILE77) to (ASP207) IRAK-4 INHIBITORS (PART II)- A STRUCTURE BASED ASSESSMENT OF IMIDAZO[1,2 A]PYRIDINE BINDING | JNK3 KINASE, INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, EPILEPSY, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3new:A (GLY36) to (ILE166) P38-ALPHA COMPLEXED WITH COMPOUND 10 | KINASE, SER/THR KINASE, INTRACELLULAR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3nnv:A (SER37) to (ILE166) CRYSTAL STRUCTURE OF P38 ALPHA IN COMPLEX WITH DP437 | KINASE, TRANSFERASE
3nnw:A (GLY36) to (ILE166) CRYSTAL STRUCTURE OF P38 ALPHA IN COMPLEX WITH DP802 | KINASE, TRANSFERASE
3npc:A (GLY38) to (ILE167) CRYSTAL STRUCTURE OF JNK2 COMPLEXED WITH BIRB796 | DFG-OUT, PROTEIN KINASE, TRANSFERASE, ATP BINDING, TYPE II KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3npc:B (GLY38) to (ILE167) CRYSTAL STRUCTURE OF JNK2 COMPLEXED WITH BIRB796 | DFG-OUT, PROTEIN KINASE, TRANSFERASE, ATP BINDING, TYPE II KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ccu:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPAN-2-OL | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
5fto:A (GLY1128) to (ILE1268) CRYSTAL STRUCTURE OF THE ALK KINASE DOMAIN IN COMPLEX WITH ENTRECTINIB | TRANSFERASE, KINASE INHIBITORS, CANCER, DRUG DISCOVERY, ALK, TRK, ROS1, ANAPLASTIC LARGE CELL LYMPHOMA (ALCL), NON SMALL CELL LARGE CANCER (NSCLC), NEUROBLASTOMA, COLORECTAL CANCER (CRC)
5ftq:A (GLU1132) to (ILE1268) CRYSTAL STRUCTURE OF THE ALK KINASE DOMAIN IN COMPLEX WITH CMPD 17 | TRANSFERASE, KINASE INHIBITORS, CANCER, DRUG DISCOVERY, ALK, TRK, ROS1, ANAPLASTIC LARGE CELL LYMPHOMA (ALCL), NON SMALL CELL LARGE CANCER (NSCLC), NEUROBLASTOMA, COLORECTAL CANCER (CRC)
3nup:A (GLY25) to (LEU161) CDK6 (MONOMERIC) IN COMPLEX WITH INHIBITOR | KINASE, PROTEIN KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4cfw:A (GLY16) to (LEU143) STRUCTURE-BASED DESIGN OF C8-SUBSTITUTED O6- CYCLOHEXYLMETHOXYGUANINE CDK1 AND 2 INHIBITORS. | CELL CYCLE, STRUCTURE-BASED DRUG DESIGN, CONFORMATIONAL RESTRAINT, REVERSED BINDING MODE
4cfx:C (VAL17) to (LEU143) STRUCTURE-BASED DESIGN OF C8-SUBSTITUTED O6-CYCLOHEXYLMETHOXYGUANINE CDK1 AND 2 INHIBITORS. | CELL CYCLE, STRUCTURE-BASED DRUG DESIGN, CONFORMATIONAL RESTRAINT, REVERSED BINDING MODE
3cs9:A (GLU255) to (VAL379) HUMAN ABL KINASE IN COMPLEX WITH NILOTINIB | NILOTINIB, AMN107, KINASE, ABL, ALTERNATIVE SPLICING, ATP- BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ABL KINASE WT IN COMPLEX WITH NVP-AMN107
3nww:A (GLY36) to (ASP168) P38 ALPHA KINASE COMPLEXED WITH A 2-AMINOTHIAZOL-5-YL-PYRIMIDINE BASED INHIBITOR | P38 MAP KINASE, SERINE/THREONINE-PROTINE KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ctq:A (SER37) to (ILE166) STRUCTURE OF MAP KINASE P38 IN COMPLEX WITH A 1-O-TOLYL-1,2, 3-TRIAZOLE-4-CARBOXAMIDE | TWO LOBE KINASE FOLD, N-TERMINAL BETA-SHEET, C-TERMINAL ALPHA-HELIX, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3o0g:B (GLY16) to (LEU142) CRYSTAL STRUCTURE OF CDK5:P25 IN COMPLEX WITH AN ATP ANALOGUE | KINASE, KINASE ACTIVATOR COMPLEX, KINASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
4cmo:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 2-((1R)-1-((3-AMINO-6-(2- METHOXYPYRIDIN- -YL)PYRAZIN-2-YL)OXY)ETHYL)-4-FLUORO-N-METHYLBENZAMIDE | TRANSFERASE, RECEPTOR TYROSINE KINASE INHIBITOR
4cmt:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)-5-(3-(METHYLSULFONYL)PHENYL)PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cmu:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (10R)-7-AMINO-12-FLUORO-1,3,10, 16-TETRAMETHYL-16,17-DIHYDRO-1H-8,4-(METHENO)PYRAZOLO(4,3- H)(2,5,11)BENZOXADIAZACYCLOTETRADECIN-15(10H)-ONE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cnh:A (GLU1129) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2- METHOXYPHENYL)ETHOXY)-5-(1-METHYL-1H-1,2,3-TRIAZOL-5-YL) PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cnh:B (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2- METHOXYPHENYL)ETHOXY)-5-(1-METHYL-1H-1,2,3-TRIAZOL-5-YL) PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
3o8p:A (SER37) to (GLY168) CONFORMATIONAL PLASTICITY OF P38 MAP KINASE DFG MOTIF MUTANTS IN RESPONSE TO INHIBITOR BINDING | TRANSFERASE
3o8t:A (GLY36) to (ILE166) CONFORMATIONAL PLASTICITY OF P38 MAP KINASE DFG-MOTIF MUTANTS IN RESPONSE TO INHIBITOR BINDING | TRANSFERASE
3d4q:A (LYS473) to (ILE592) PYRAZOLE-BASED INHIBITORS OF B-RAF KINASE | KINASE, ATP-BINDING, CARDIOMYOPATHY, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ZINC-FINGER
4ctb:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (5R)-8-AMINO-3-FLUORO-5,19-DIMETHYL-20-OXO-5,18,19,20- TETRAHYDRO-7,11-(AZENO)PYRIDO(2',1':2,3)IMIDAZO(4,5-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-14-CARBONITRILE | TRANSFERASE, INHIBITOR
4cv8:A (SER537) to (ASP664) MPS1 KINASE WITH 3-AMINOPYRIDIN-2-ONE INHIBITORS | TRANSFERASE, INHIBITOR
3oc1:A (GLY36) to (LEU167) CONFORMATIONAL PLASTICITY OF P38 MAP KINASE DFG MOTIF MUTANTS IN RESPONSE TO INHIBITOR BINDING | TRANSFERASE
3dak:B (ALA29) to (ILE162) CRYSTAL STRUCTURE OF DOMAIN-SWAPPED OSR1 KINASE DOMAIN | SERINE/THREONINE PROTEIN KINASE, STE20, DOMAIN-SWAPPING, ATP-BINDING, KINASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE
3ocg:A (GLY36) to (ASP168) P38 ALPHA KINASE COMPLEXED WITH A 5-AMINO-PYRAZOLE BASED INHIBITOR | P38 MAP KINASE, SERINE/THREONINE-PROTINE KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4cxa:A (GLN740) to (LEU875) CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLIN K COMPLEX BOUND TO AMPPNP | TRANSFERASE, KINASE
3oht:A (SER38) to (ASP169) CRYSTAL STRUCTURE OF SALMO SALAR P38ALPHA | KINASE SERINE/THREONINE-PROTEIN KINASE TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3oht:B (SER38) to (ASP169) CRYSTAL STRUCTURE OF SALMO SALAR P38ALPHA | KINASE SERINE/THREONINE-PROTEIN KINASE TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4tyg:A (GLN496) to (ASP630) STRUCTURAL ANALYSIS OF THE HUMAN FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE | FIBROBLAST GROWTH FACTOR RECEPTOR, KINASE, TRANSFERASE, DOVITINIB, PONATINB, PROTEROS BIOSTRUCTURES GMBH
4tyh:A (GLY76) to (LEU205) TERNARY COMPLEX OF P38 AND MK2 WITH A P38 INHIBITOR | P38, MK2, P38 INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ds6:A (SER37) to (ASP168) P38 COMPLEX WITH A PHTHALAZINE INHIBITOR | KINASE INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3ds6:B (SER37) to (ASP168) P38 COMPLEX WITH A PHTHALAZINE INHIBITOR | KINASE INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3ds6:C (SER37) to (ASP168) P38 COMPLEX WITH A PHTHALAZINE INHIBITOR | KINASE INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3dt1:A (SER37) to (ASP168) P38 COMPLEXED WITH A QUINAZOLINE INHIBITOR | KINASE INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3os3:A (LYS84) to (LEU206) MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN COMPLEX WITH CH4858061 AND MGATP | KINASE, KINASE INHIBITOR, ALLOSTERIC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hbe:A (GLY33) to (ALA172) CDK8-CYCC IN COMPLEX WITH 8-[3-CHLORO-5-(1-METHYL-2,2-DIOXO-2, 3- DIHYDRO-1H-2L6-BENZO[C]ISOTHIAZOL-5-YL)-PYRIDIN- 4-YL]-1-OXA-3,8- DIAZA-SPIRO[4.5]DECAN-2-ONE | CDK8 KINASE / CYCLIN C, TRANSFERASE
3dv3:A (LYS84) to (LYS205) MEK1 WITH PF-04622664 BOUND | KINASE, KINASE INHIBITORS, MEK, ATP-BINDING, DISEASE MUTATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, TYROSINE-PROTEIN KINASE
3otv:A (GLN45) to (LEU166) CRYSTAL STRUCTURE OF THE INTRACELLULAR DOMAIN OF RV3910 FROM MYCOBACTERIUM TUBERCULOSIS | PEPTIDOGLYCAN, SER/THR KINASE, PSEUDOKINASE, REGULATION, MEMBRANE, TRANSFERASE
4u3y:A (GLY37) to (LEU169) APO MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (MAP4K4) | KINASE, TRANSFERASE
4u3z:A (TYR40) to (LEU169) APO MAP4K4 T181E PHOSPHOMIMETIC MUTANT | KINASE, TRANSFERASE
4u41:A (GLN38) to (ASP171) MAP4K4 BOUND TO INHIBITOR COMPOUND 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4deh:A (GLY1090) to (VAL1220) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH TRIAZOLOPYRIDINONE INHIBITOR 3 | PROTO-ONCOGENE, RECEPTOR TYROSINE KINASE, RTK, ATP-BINDING, HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, HGF/SF, PHOSPHOPROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4dei:A (GLY1090) to (VAL1220) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH TRIAZOLOPYRIDINONE INHIBITOR 24 | PROTO-ONCOGENE, INHIBITOR, RECEPTOR TYROSINE KINASE, RTK, ATP- BINDING, HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, HGF/SF, PHOSPHOPROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3dxn:A (GLY35) to (ILE165) CRYSTAL STRUCTURE OF THE CALCIUM-DEPENDENT KINASE FROM TOXOPLASMA GONDII, 541.M00134, KINASE DOMAIN. | CDPK, CALCIUM DEPENDENT KINASE, CALMODULIN, PARASITE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, TRANSFERASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
3p4k:A (GLY36) to (ILE166) THE THIRD CONFORMATION OF P38A MAP KINASE OBSERVED IN PHOSPHORYLATED P38A AND IN SOLUTION | KINASE, PHOSPHORYLATION, TRANSFERASE
3p5k:A (SER37) to (ILE166) P38 INHIBITOR-BOUND | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hnb:A (GLY33) to (ALA172) CDK8-CYCC IN COMPLEX WITH [6-HYDROXY-3-(3-METHYL-BENZYL)-1H-INDAZOL-5- YL]-((S)-3-HYDROXY-PYRROLIDIN-1-YL)-METHANONE | CDK8 KINASE / CYCLIN C, TRANSFERASE
3p7b:A (GLY36) to (ILE166) P38 INHIBITOR-BOUND | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3p7c:A (SER37) to (ILE166) P38 INHIBITOR-BOUND | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3p86:A (THR564) to (VAL692) CRYSTAL STRUCTURE OF CTR1 KINASE DOMAIN MUTANT D676N IN COMPLEX WITH STAUROSPORINE | KINASE, ETR1, ERS1, ETR2, PHOSPHORYLATION, TRANSFERASE
3p86:B (ALA568) to (ASP694) CRYSTAL STRUCTURE OF CTR1 KINASE DOMAIN MUTANT D676N IN COMPLEX WITH STAUROSPORINE | KINASE, ETR1, ERS1, ETR2, PHOSPHORYLATION, TRANSFERASE
4u97:B (GLY198) to (SER328) CRYSTAL STRUCTURE OF ASYMMETRIC IRAK4 DIMER | KINASE, AUTOPHOSPHORYLATION, DIMER, TRANSFERASE
3e3b:X (GLU56) to (LEU174) CRYSTAL STRUCTURE OF CATALYTIC SUBUNIT OF HUMAN PROTEIN KINASE CK2ALPHA PRIME WITH A POTENT INDAZOLE-DERIVATIVE INHIBITOR | CRYSTAL STRUCTURE, CASEIN KINASE 2, CK2ALPHA PRIME, CK2ALPHA INHIBITOR, SELECTIVE KINASE INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
4u9a:B (GLY198) to (ASP329) SULPHUR ANOMALOUS CRYSTAL STRUCTURE OF ASYMMETRIC IRAK4 DIMER | KINASE, SULPHUR ANOMALOUS, AUTOPHOSPHORYLATION, TRANSFERASE
3pp1:A (LYS84) to (LEU206) CRYSTAL STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK 1) IN COMPLEX WITH LIGAND AND MGATP | KINASE DOMAIN, KINASE, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5iey:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF A CDK INHIBITOR BOUND TO CDK2 | ANTINEOPLASTIC AGENTS, CYCLIN-DEPENDENT KINASES, DOSE-RESPONSE RELATIONSHIP, DRUG, DRUG DISCOVERY, HELA CELLS, MOLECULAR STRUCTURE, NEOPLASMS, PROTEIN KINASE INHIBITORS, PYRIMIDINES, STRUCTURE- ACTIVITY RELATIONSHIP, STRUCTURE-KINETICS RELATIONSHIP, SULFOXIDES, BIOPHYSICAL ASSAYS, TUMOR, HUMANS, TRANSFERASE
4e73:A (GLY38) to (ILE167) CRYSTAL STRUCTURE OF JNK1BETA-JIP IN COMPLEX WITH AN AZAQUINOLONE INHBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4usd:A (LYS49) to (ASP175) HUMAN STK10 (LOK) WITH SB-633825 | TRANSFERASE
4usd:B (LYS49) to (ASP175) HUMAN STK10 (LOK) WITH SB-633825 | TRANSFERASE
4use:A (GLY48) to (ASP175) HUMAN STK10 (LOK) WITH SB-633825 | TRANSFERASE
4use:B (GLY48) to (ASP175) HUMAN STK10 (LOK) WITH SB-633825 | TRANSFERASE
3ptg:A (GLY76) to (ASP207) DESIGN AND SYNTHESIS OF A NOVEL, ORALLY EFFICACIOUS TRI-SUBSTITUTED THIOPHENE BASED JNK INHIBITOR | JNK INHIBITOR, THIOPHENE, NEURODEGENERATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eh2:A (GLY36) to (ASP168) HUMAN P38 MAP KINASE IN COMPLEX WITH NP-F1 AND RL87 | MAP KINASE INSERT, KINASE-LIGAND COMPLEX, NP-FRAGMENT, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4eh6:A (GLY36) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH NP-F5 AND RL87 | MAP KINASE INSERT, KINASE-LIGAND COMPLEX, NP-FRAGMENT, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4eh7:A (GLY36) to (ASP168) HUMAN P38 MAP KINASE IN COMPLEX WITH NP-F6 AND RL87 | MAP KINASE INSERT, KINASE-LIGAND COMPLEX, NP-FRAGMENT, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4ehg:A (THR470) to (ILE592) B-RAF KINASE DOMAIN IN COMPLEX WITH AN AMINOPYRIDIMINE-BASED INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pxq:A (VAL17) to (LEU143) CDK2 IN COMPLEX WITH 3 MOLECULES OF 8-ANILINO-1-NAPHTHALENE SULFONATE | PROTEIN KINASE, CDK2, ALLOSTERIC LIGAND, ANS, TRANSFERASE
3pxy:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR JWS648 | PROTEIN KINASE, CDK2, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pxz:A (GLY16) to (LEU143) CDK2 TERNARY COMPLEX WITH JWS648 AND ANS | PROTEIN KINASE, CDK2, ALLOSTERIC LIGAND, ANS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3py0:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR SU9516 | PROTEIN KINASE, CDK2, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3py1:A (GLY16) to (LEU143) CDK2 TERNARY COMPLEX WITH SU9516 AND ANS | PROTEIN KINASE, CDK2, ALLOSTERIC LIGAND, ANS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pyy:A (GLU274) to (VAL398) DISCOVERY AND CHARACTERIZATION OF A CELL-PERMEABLE, SMALL-MOLECULE C- ABL KINASE ACTIVATOR THAT BINDS TO THE MYRISTOYL BINDING SITE | TYROSINE KINASE, TRANSFERASE
3pze:A (GLY38) to (ASP169) JNK1 IN COMPLEX WITH INHIBITOR | KINASE JNK1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eol:A (GLY16) to (LEU143) THR 160 PHOSPHORYLATED CDK2 H84S, Q85M, K89D - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR RO3306 | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eqm:D (SER22) to (ASP151) STRUCTURAL ANALYSIS OF STAPHYLOCOCCUS AUREUS SERINE/THREONINE KINASE PKNB | KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
4eqm:E (SER22) to (ASP151) STRUCTURAL ANALYSIS OF STAPHYLOCOCCUS AUREUS SERINE/THREONINE KINASE PKNB | KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
4eqm:F (SER22) to (ASP151) STRUCTURAL ANALYSIS OF STAPHYLOCOCCUS AUREUS SERINE/THREONINE KINASE PKNB | KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
4equ:A (GLY48) to (LEU173) HUMAN STK-10 (LOK) KINASE DOMAIN IN DFG-OUT CONFORMATION WITH INHIBITOR DSA-7 | SERINE/THREONINE KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4equ:B (GLY48) to (LEU173) HUMAN STK-10 (LOK) KINASE DOMAIN IN DFG-OUT CONFORMATION WITH INHIBITOR DSA-7 | SERINE/THREONINE KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q5i:A (TYR68) to (GLY213) CRYSTAL STRUCTURE OF PBANKA_031420 | CDPK, PLASMODIUM, MALARIA, CALCIUM DEPENDENT PROTEIN KINASE, PHOSPHOTRANSFERASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
5iui:A (GLU1129) to (ILE1268) CRYSTAL STRUCTURE OF ANAPLASTIC LYPHOMA KINASE (ALK) IN COMPLEX WITH 4 | CATALYTIC DOMAIN, TRANSFERASE
4erw:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH STAUROSPORINE | PROTEIN KINASE, TRANSFERASE-ANTIBIOTIC COMPLEX
4ewq:A (GLY36) to (ILE166) HUMAN P38 ALPHA MAPK IN COMPLEX WITH A PYRIDAZINE BASED INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, PROTEIN KINASE DOMAIN, TRANSFERASE, ATP BINDING, PHOSPHORYLATION, CYTOSOL, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ez3:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH NSC 134199 | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qgw:A (LEU379) to (VAL498) CRYSTAL STRUCTURE OF ITK KINASE BOUND TO AN INHIBITOR | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ql8:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR JWS-6-260 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4f9w:A (GLY36) to (ILE166) HUMAN P38ALPHA MAPK IN COMPLEX WITH A NOVEL AND SELECTIVE SMALL MOLECULE INHIBITOR | PROTEIN KINASE CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4f9y:A (GLY36) to (ILE166) HUMAN P38 ALPHA MAPK IN COMPLEX WITH A NOVEL AND SELECTIVE SMALL MOLECULE INHIBITOR | PROTEIN KINASE CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fa2:A (GLY36) to (ASP168) HUMAN P38 ALPHA MITOGEN-ACTIVATED KINASE IN COMPLEX WITH SB239063 | PROTEIN KINASE CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qqg:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR L2-5 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qrk:A (GLU258) to (VAL379) THE CRYSTAL STRUCTURE OF HUMAN ABL1 KINASE DOMAIN IN COMPLEX WITH DP- 987 | ABL1, KINASE, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qru:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR NSK-MC1-12 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qts:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-12 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qtu:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-132 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qtw:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-13 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qtx:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-35 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qtz:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-36 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qud:A (SER37) to (ASP168) HUMAN P38 MAP KINASE IN COMPLEX WITH 2-AMINO-PHENYLAMINO-BENZOPHENONE | KINASE DOMAIN, PHOSPHATE TRANSFERASE, BENZOPHENONE DERIVATIVE, TRANSFERASE
3qxp:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-3-89 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qzg:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR JWS-6-76 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qzh:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-124 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qzi:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-126 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r1s:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-127 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r28:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-140 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fko:A (GLY16) to (LEU143) CRYSTAL STRUCTURE OF THE CDK2 IN COMPLEX WITH THIAZOLYLPYRIMIDINE INHIBITOR | ALPHA AND BETA PROTEIN (A+B), TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r63:A (GLY35) to (ILE163) STRUCTURE OF ERK2 (SPE) MUTANT (S246E) | NUCLEAR TRANSPORT, PHOSPHORYLATION, KINASE FOLD, KINASE, ATP BINDING, TRANSFERASE
3r73:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-164 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r7e:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-67 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r8l:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR L3-4 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r8u:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-1-132 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r9d:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-135 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r9h:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-142 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rah:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-22 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rai:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-160 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rak:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-32 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ral:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-2-34 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fob:A (GLY1128) to (ILE1268) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH ACYLIMINOBENZIMIDAZOLE INHIBITOR 1 | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, IN SITU PROTEOLYSIS, TRANSFERASE-INHIBITOR COMPLEX
4foc:A (GLY1128) to (ILE1268) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH ACYLIMINOBENZIMIDAZOLE INHIBITOR 2 | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, IN SITU PROTEOLYSIS, TRANSFERASE-INHIBITOR COMPLEX
4fuy:A (GLY35) to (ILE163) CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK2 | TRANSFERASE
4fv3:A (GLY35) to (ILE163) CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK6 | TRANSFERASE
4fv7:A (GLY35) to (ILE163) CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH E94 | TRANSFERASE
5jsm:A (THR470) to (ASP594) BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-3-VEM | KINASE, DIMER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5jsm:B (GLY469) to (ASP594) BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-3-VEM | KINASE, DIMER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5jsm:C (LYS473) to (ASP594) BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-3-VEM | KINASE, DIMER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4g1w:A (GLY38) to (ASP169) CRYSTAL STRUCTURE OF JNK1 IN COMPLEX WITH JIP1 PEPTIDE AND 7-FLUORO-3- [4-(2-HYDROXY-ETHANESULFONYL)-BENZYL]-4-OXO-1-PHENYL-1,4-DIHYDRO- QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER | KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5kbr:B (THR283) to (LEU405) PAK1 IN COMPLEX WITH 7-AZAINDOLE INHIBITOR | SERINE/THREONINE-PROTEIN KINASE PAK1, KINASE, TRANSFERASE
4gg7:A (GLY1095) to (VAL1220) CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH NOVEL INHIBITOR | C-MET INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5ko1:A (SER215) to (ALA348) PSEUDOKINASE DOMAIN OF MLKL BOUND TO COMPOUND 4. | PSEUDOKINASE DOMAIN MLKL TYPE1 INHIBITOR, MEMBRANE PROTEINS-INHIBITOR COMPLEX
5kz0:A (PHE1127) to (ILE1268) STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-[(1R)- 1-{[2-AMINO-5-(1,3-DIMETHYL-1H-PYRAZOL-4-YL)PYRIDIN-3-YL]OXY}ETHYL]- 4-FLUORO-N,N-DIMETHYLBENZAMIDE | KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5l1z:A (GLU32) to (LEU165) TAR COMPLEX WITH HIV-1 TAT-AFF4-P-TEFB | HIV-1 TAR, PROTEIN-RNA COMPLEX, TRANSCRIPTION, PROTEIN KINASE, TRANSCRIPTION-RNA COMPLEX
5lar:A (SER37) to (ILE166) CRYSTAL STRUCTURE OF P38 ALPHA MAPK14 IN COMPLEX WITH VPC00628 | TRANSFERASE, PROTEIN KINASE, MAPK, INHIBITOR COMPLEX, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
5ljj:A (SER537) to (ASP664) CRYSTAL STRUCTURE OF HUMAN MPS1 (TTK) IN COMPLEX WITH REVERSINE | MPS1, REVERSINE, TTK, KINASE, MITOSIS CHECKPOINT, TRANSFERASE
5t6i:A (GLU64) to (ASP195) CRYSTAL STRUCTURE OF TGCDPK1 FROM TOXOPLASMA GONDII COMPLEXED WITH 5GB | STRUCTURAL GENOMICS CONSORTIUM, SGC, CDPKS, SERINE/THREONINE PROTEIN KINASE, NUCLEOTIDE-BINDING, TRANSFERASE
3e93:A (GLY36) to (ILE166) CRYSTAL STRUCTURE OF P38 KINASE IN COMPLEX WITH A BIARYL AMIDE INHIBITOR | P38, SERINE/THREONINE PROTEIN KINASE, MAP KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1a9u:A (GLY36) to (ILE166) THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580 | TRANSFERASE, MAP KINASE, SERINE/THREONINE-PROTEIN KINASE, P38
2oib:C (GLY198) to (ILE327) CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN APO FORM | KINASE, HELIC C, TRANSFERASE
3s00:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR L4-14 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3s0o:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-1-138 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1nxk:D (GLY76) to (LEU205) CRYSTAL STRUCTURE OF STAUROSPORINE BOUND TO MAP KAP KINASE 2 | PROTEIN KINASE, MK2, PHOSPHORYLATION, STAUROSPORINE, TRANSFERASE
2bhe:A (GLY16) to (LEU143) HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE | 3D-STRUCTURE, ARYLAMINE N-ACETYLTRANSFERASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, DRUG METABOLISM, ISONIAZID, MITOSIS, MYCOBACTERIA, NAT, PHOSPHORYLATION, POLYMORPHISM, SERINE-THREONINE -PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3sqq:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-3-96 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1p38:A (SER37) to (LEU167) THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTOMS RESOLUTION | TRANSFERASE, MAP KINASE, SERINE/THREONINE-PROTEIN KINASE, P38
4xs2:B (GLY198) to (SER328) IRAK4-INHIBITOR CO-STRUCTURE | KINASE, PHOSPHATASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4imy:A (GLU32) to (LEU165) THE AFF4 SCAFFOLD BINDS HUMAN P-TEFB ADJACENT TO HIV TAT | TRANSCRIPTIONAL CDK9-CYCT1 COMPLEX, PHOSPHORYLATED, INTRINSICALLY DISORDERED AFF4, REGULATION OF TRANSCRIPTION ELONGATION, SER/THR KINASE, PHOSPHORYLATION OF POLII-CTD, DSIF, AND NELF, HIV-1 TAT, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, NUCLEUS, TRANSFERASE
4imy:E (GLU32) to (LEU165) THE AFF4 SCAFFOLD BINDS HUMAN P-TEFB ADJACENT TO HIV TAT | TRANSCRIPTIONAL CDK9-CYCT1 COMPLEX, PHOSPHORYLATED, INTRINSICALLY DISORDERED AFF4, REGULATION OF TRANSCRIPTION ELONGATION, SER/THR KINASE, PHOSPHORYLATION OF POLII-CTD, DSIF, AND NELF, HIV-1 TAT, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, NUCLEUS, TRANSFERASE
3gcv:A (GLY36) to (ILE166) HUMAN P38 MAP KINASE IN COMPLEX WITH RL62 | DFG-OUT, TYPE II, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1ds5:B (SER51) to (LEU173) DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME. | PROTEIN-COMPLEX, TETRAMER, TRANSFERASE
1ds5:C (SER51) to (LEU173) DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME. | PROTEIN-COMPLEX, TETRAMER, TRANSFERASE
1ds5:D (SER51) to (LEU173) DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME. | PROTEIN-COMPLEX, TETRAMER, TRANSFERASE
4izy:A (ILE39) to (ASP169) CRYSTAL STRUCTURE OF JNK1 IN COMPLEX WITH JIP1 PEPTIDE AND 4-{4-[4-(4- METHANESULFONYL-PIPERIDIN-1-YL)-INDOL-1-YL]-PYRIMIDIN-2-YLAMINO}- CYCLOHEXAN | KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tn8:A (GLU32) to (LEU165) CDK9/CYCLIN T IN COMPLEX WITH CAN508 | CYCLIN DEPENDENT KINASE, KINASE, CYCLIN, PHOSPHOTRANSFER, CDK-CYCLIN COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2rg6:A (SER37) to (ASP168) PHENYLALANINE PYRROLOTRIAZINE P38 ALPHA MAP KINASE INHIBITOR COMPOUND 11J | SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE
4z55:A (GLU1132) to (ILE1268) ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN COMPLEXED WITH PYRAZOLOPYRIMIDINE DERIVATIVE OF LDK378 | CATALYTIC DOMAIN, TRANSFERASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3v6r:A (GLY76) to (ASP207) DISCOVERY OF POTENT AND SELECTIVE COVALENT INHIBITORS OF JNK | KINASE FOLD, APOPTOSIS, MAP KINASE, CYS MODIFICATION, PHOSPHORYLATION, JNK, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3v6r:B (GLY76) to (ASP207) DISCOVERY OF POTENT AND SELECTIVE COVALENT INHIBITORS OF JNK | KINASE FOLD, APOPTOSIS, MAP KINASE, CYS MODIFICATION, PHOSPHORYLATION, JNK, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lg4:B (GLY39) to (LEU162) STRUCTURAL BASIS FOR AUTOACTIVATION OF HUMAN MST2 KINASE AND ITS REGULATION BY RASSF5 | HIPPO, MST AUTOACTIVATION, DIMERIZATION, SIGNALING PROTEIN
4lg4:C (GLY39) to (LEU162) STRUCTURAL BASIS FOR AUTOACTIVATION OF HUMAN MST2 KINASE AND ITS REGULATION BY RASSF5 | HIPPO, MST AUTOACTIVATION, DIMERIZATION, SIGNALING PROTEIN
2h8h:A (MET283) to (VAL402) SRC KINASE IN COMPLEX WITH A QUINAZOLINE INHIBITOR | SRC KINASE, TRANSFERASE
4loq:A (GLY36) to (LEU167) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM WITH BOUND SULPHATE) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4loq:B (GLY36) to (LEU167) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM WITH BOUND SULPHATE) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4loq:C (GLY36) to (LEU167) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM WITH BOUND SULPHATE) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
4loq:D (GLY36) to (LEU167) STRUCTURAL BASIS OF AUTOACTIVATION OF P38 ALPHA INDUCED BY TAB1 (TETRAGONAL CRYSTAL FORM WITH BOUND SULPHATE) | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, KINASE-REGULATORY PROTEIN COMPLEX, MAPK, AUTOACTIVATION, AUTOPHOSPHORYLATION, TRANSFERASE
2wqo:A (GLY20) to (LEU157) STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950 | KINASE, NUCLEUS, MEIOSIS, MITOSIS, CYTOPLASM, ALTERNATIVE SPLICING, SERINE/THREONINE-PROTEIN KINASE, METAL-BINDING, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, MAGNESIUM, CELL CYCLE, ATP-BINDING, TRANSFERASE, COILED COIL, POLYMORPHISM, CELL DIVISION
5aa8:A (GLY1128) to (ILE1268) STRUCTURE OF C1156Y,L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12- FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H- 8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR, MUTANT
5aaa:A (GLY1128) to (ILE1268) STRUCTURE OF L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
2xnm:A (GLY20) to (LEU157) STRUCTURE OF NEK2 BOUND TO CCT | TRANSFERASE, CENTROSOME, MITOSIS, CELL CYCLE
3zdu:A (THR17) to (LEU141) CRYSTAL STRUCTURE OF THE HUMAN CDKL3 KINASE DOMAIN | TRANSFERASE, PHOSPHO-MIMETIC
1w83:A (GLY36) to (ILE166) P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE/INHIBITOR, KINASE/INHIBITOR COMPLEX, P38, KINASE, INHIBITOR COMPLEX
2y8o:A (GLY36) to (LEU167) CRYSTAL STRUCTURE OF HUMAN P38ALPHA COMPLEXED WITH A MAPK DOCKING PEPTIDE | TRANSFERASE, SIGNALLING, MAP KINASE PATHWAY, PROTEIN-PROTEIN INTERACTION
3k5v:B (GLU274) to (VAL398) STRUCTURE OF ABL KINASE IN COMPLEX WITH IMATINIB AND GNF-2 | KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
5dey:B (GLY282) to (ASP407) CRYSTAL STRUCTURE OF PAK1 IN COMPLEX WITH AN INHIBITOR COMPOUND G-5555 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3l9p:A (GLU1132) to (ILE1268) CRYSTAL STRUCTURE OF THE ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | KINASE DOMAIN, ATP-BINDING, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3lco:A (ALA599) to (ILE794) INHIBITOR BOUND TO A DFG-OUT STRUCTURE OF THE KINASE DOMAIN OF CSF-1R | ATP-BINDING, DISULFIDE BOND, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3lcs:A (GLU1132) to (ILE1268) CRYSTAL STRUCTURE OF THE ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | KINASE DOMAIN, ATP-BINDING, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE
4aqc:B (GLY861) to (ILE992) TRIAZOLOPYRIDINE-BASED INHIBITOR OF JANUS KINASE 2 | TRANSFERASE, ATP-BINDING
3mgy:A (SER37) to (ASP168) MUTAGENESIS OF P38 MAP KINASE ESHTABLISHES KEY ROLES OF PHE169 IN FUNCTION AND STRUCTURAL DYNAMICS AND REVEALS A NOVEL DFG-OUT STATE | TRANSFERASE, SIGNALING PROTEIN
3mpa:A (SER37) to (ILE166) CONFORMATIONAL PLASTICITY OF P38 MAP KINASE DFG MOTIF MUTANTS IN RESPONSE TO INHIBITOR BINDING | TRANSFERASE
5etf:A (SER37) to (ILE166) STRUCTURE OF DEAD KINASE MAPK14 WITH BOUND THE KIM DOMAIN OF MKK6 | MAPK14, MKK6, KIM DOMAIN, PEPTIDE-PROTEIN COMPLEX, TRANSFERASE
4r1v:A (LYS1103) to (VAL1220) IDENTIFICATION AND OPTIMIZATION OF PYRIDAZINONES AS POTENT AND SELECTIVE C-MET KINASE INHIBITORS | PROTEIN KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ccb:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 3-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)-5-(5-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR
4cd0:A (GLU1132) to (ILE1268) STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPANE-1,2-DIOL | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cli:A (GLY1128) to (ILE1268) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15 -OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H) (2,5,11)BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE). | TRANSFERASE, INHIBITOR
5g6v:A (ALA177) to (LEU302) CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INHIBITOR | TRANSFERASE
5g6v:B (ALA177) to (LEU302) CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INHIBITOR | TRANSFERASE
3oef:X (GLY36) to (ILE166) CRYSTAL STRUCTURE OF Y323F INACTIVE MUTANT OF P38ALPHA MAP KINASE | MAP KINASE, INACTIVE MUTANT, TCR MEDIATED ACTIVATION, KINASE FOLD, KINASE, SUBSTRATES, PHOSPHOTASES, UPSTREAM ACTIVATORS, Y323F, TRANSFERASE
3dkc:A (GLY1095) to (ALA1221) STRUCTURE OF MET RECEPTOR TYROSINE KINASE IN COMPLEX WITH ATP | DRUG DISCOVERY, C-MET KINASE, FRAGMENT BASED, MEMBRANE, RECEPTOR, TRANSMEMBRANE, ONCOPROTEIN
4usf:A (LYS47) to (ASP173) HUMAN SLK WITH SB-440719 | TRANSFERASE
3psb:B (THR470) to (ILE592) FURO[2,3-C]PYRIDINE-BASED INDANONE OXIMES AS POTENT AND SELECTIVE B- RAF INHIBITORS | KINASE, ATP-BINDING, CARDIOMYOPATHY, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, ZINC-FINGER, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3pxr:A (GLY16) to (LEU143) APO CDK2 CRYSTALLIZED FROM JEFFAMINE | PROTEIN KINASE, CDK2, JEFFAMINE, TRANSFERASE
4f7s:A (GLY33) to (ALA172) CRYSTAL STRUCTURE OF HUMAN CDK8/CYCC IN THE DMG-IN CONFORMATION | PROTEIN KINASE COMPLEX, PROTEROS, TRANSFERASE-TRANSCRIPTION-INHIBITOR COMPLEX
3qwk:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-150 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qxo:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-84 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r1q:A (VAL17) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-102 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r2b:H (LYS77) to (LEU205) MK2 KINASE BOUND TO COMPOUND 5B | KINASE DOMAIN WITH BOUND INHIBITOR, KINASE DOMAIN, PHOSPHOTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fl2:A (GLY388) to (ILE510) STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYK ACTIVATION SWITCH | TRANSFERASE, PROTEIN KINASE
4fl3:A (GLY388) to (ILE510) STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYK ACTIVATION SWITCH | TRANSFERASE, PROTEIN KINASE
3r6x:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR KVR-1-158 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r8v:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-1-135 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fod:A (GLY1128) to (ILE1268) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH ACYLIMINOBENZIMIDAZOLE INHIBITOR 36 | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, TRANSFERASE-INHIBITOR COMPLEX
4fvr:A (GLN572) to (LEU697) CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN MUTANT V617F (MG- ATP-BOUND FORM) | JANUS PROTEIN KINASE, PSEUDOKINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE
5jzn:B (PHE401) to (LEU531) CRYSTAL STRUCTURE OF DCLK1-KD IN COMPLEX WITH NVP-TAE684 | KINASE, DOUBLECORTIN, TRANSFERASE
4g6l:A (GLY33) to (ALA172) CRYSTAL STRUCTURE OF HUMAN CDK8/CYCC IN THE DMG-IN CONFORMATION | PROTEIN KINASE COMPLEX, PROTEROS, TRANSFERASE-TRANSCRIPTION COMPLEX
4gcj:A (GLY16) to (LEU143) CDK2 IN COMPLEX WITH INHIBITOR RC-3-89 | PROTEIN KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5knj:A (SER215) to (PHE350) PSEUDOKINASE DOMAIN OF MLKL BOUND TO COMPOUND 1. | PSEUDOKINASE DOMAIN MLKL COMPOUND 1 GFE OUT TYPE 2 INHIBITOR, MEMBRANE PROTEINS-INHIBITOR COMPLEX