1a1c:A (TRP151) to (HIS236) C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(- (CH2)3-CYCLOPENTYL)) | COMPLEX (TRANSFERASE/PEPTIDE)
1a1e:A (TRP151) to (HIS236) C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3- BUTYLPIPERIDINE) | COMPLEX (TRANSFERASE/PEPTIDE)
1a1e:B (TRP151) to (HIS236) C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3- BUTYLPIPERIDINE) | COMPLEX (TRANSFERASE/PEPTIDE)
4h1o:A (TRP6) to (MET82) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH D61G MUTATION | ALPHA/BETA PROTEINS, SH2 DOMAIN, PHOSPHATASE DOMAIN, TYROSINE PHOSPHATASE SHP-2, HYDROLASE
4h1o:A (TRP112) to (ASN200) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH D61G MUTATION | ALPHA/BETA PROTEINS, SH2 DOMAIN, PHOSPHATASE DOMAIN, TYROSINE PHOSPHATASE SHP-2, HYDROLASE
2oq1:A (TRP165) to (LYS244) TANDEM SH2 DOMAINS OF ZAP-70 WITH 19-MER ZETA1 PEPTIDE | TANDEM SH2 DOMAINS, ZAP-70, TYROSINE KINASE, TRANSFERASE
4h34:A (TRP6) to (GLU83) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH Q506P MUTATION | ALPHA/BETA PROTEINS, SH2 DOMAIN, PHOSPHATASE DOMAIN, TYROSINE PHOSPHATASE SHP-2, HYDROLASE
4h34:A (TRP112) to (ASN200) CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASE SHP-2 WITH Q506P MUTATION | ALPHA/BETA PROTEINS, SH2 DOMAIN, PHOSPHATASE DOMAIN, TYROSINE PHOSPHATASE SHP-2, HYDROLASE
2b3o:A (TRP110) to (THR197) CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE SHP-1 | PROTEIN TYROSINE PHOSPHATASE, SHP-1, SIGNALING, HYDROLASE
2ozo:A (TRP163) to (LYS240) AUTOINHIBITED INTACT HUMAN ZAP-70 | INACTIVE ZAP-70, TANDEM SH2, AUTOINHIBITION, ITAM, HYDROGEN BONDING NETWORK, TCR SIGNALING, TRANSFERASE
1nzv:B (TRP254) to (HIS339) CRYSTAL STRUCTURE OF SRC SH2 DOMAIN BOUND TO DOUBLY PHOSPHORYLATED PEPTIDE PQPYIPYVPA | SH2 DOMAIN, PHOSPHOTYROSINE, TRANSFERASE
1bhf:A (TRP127) to (ALA212) P56LCK SH2 DOMAIN INHIBITOR COMPLEX | SH2 DOMAIN, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1bhh:A (TRP127) to (ASN211) FREE P56LCK SH2 DOMAIN | SH2 DOMAIN, PHOSPHORYLATION, TRANSFERASE
1bhh:B (TRP127) to (ALA212) FREE P56LCK SH2 DOMAIN | SH2 DOMAIN, PHOSPHORYLATION, TRANSFERASE
1bkl:A (TRP5) to (HIS90) SELF-ASSOCIATED APO SRC SH2 DOMAIN | V-SRC SH2 DOMAIN, PHOSPHOTYROSINE RECOGNITION DOMAIN, PP60 SRC SH2 DOMAIN
4x6s:A (TRP431) to (GLN513) GRB7 SH2 DOMAIN WITH PHOSPHOTYROSINE MIMETIC INHIBITOR PEPTIDE | SRC HOMOLOGY DOMAIN, INHIBITOR, PHOSPHOTYROSINE BINDING POCKET, SIGNALING PROTEIN-INHIBITOR COMPLEX
3s8l:A (TRP60) to (ARG136) PROTEIN-LIGAND INTERACTIONS: THERMODYNAMIC EFFECTS ASSOCIATED WITH INCREASING HYDROPHOBIC SURFACE AREA | GRB2 SH2 DOMAIN, PHOSPHOTYROSINE-CONTAINING TRIPEPTIDE, SIGNALING PROTEIN-ANTAGONIST COMPLEX
3s8o:A (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A PYXN- DERIVED TRIPEPTIDE | GRB2 SH2 DOMAIN, PHOSPHOTYROSINE-CONTAINING TRIPEPTIDE, SIGNALING PROTEIN-ANTAGONIST COMPLEX
1cwd:L (TRP5) to (ALA90) HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE | PHOSPHOTRANSFERASE, COMPLEX (PHOSPHOTRANSFERASE-PEPTIDE), PHOSPHOTRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1d1z:C (VAL3006) to (PHE3087) CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP | SH2 DOMAINS, GENE REGULATION
4xz0:A (PHE10) to (ASP90) ZAP-70-TSH2:COMPOUND-A COMPLEX | TYROSINE KINASE, CYSTEINE ADDUCT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xz0:A (TRP163) to (LYS240) ZAP-70-TSH2:COMPOUND-A COMPLEX | TYROSINE KINASE, CYSTEINE ADDUCT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xz1:A (PHE10) to (ASP90) ZAP-70-TSH2:COMPOUND-B ADDUCT | TYROSINE KINASE, CYSTEINE ADDUCT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xz1:A (TRP163) to (LEU241) ZAP-70-TSH2:COMPOUND-B ADDUCT | TYROSINE KINASE, CYSTEINE ADDUCT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1qg1:E (TRP5) to (THR83) GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE | SIGNAL TRANSDUCTION, SH2 DOMAIN, PHOSPHOTYROSYL PEPTIDE, COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE), HORMONE/GROWTH FACTOR COMPLEX
2rmx:A (TRP8) to (THR95) SOLUTION STRUCTURE OF THE SHP-1 C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM NKG2A | SH2 DOMAIN, PROTEIN-PEPTIDE COMPLEX, PHOSPHORYLATED PEPTIDE RECOGNITION, PHOSPHOTYROSINE BINDING DOMAIN, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, CYTOPLASM, HYDROLASE, NUCLEUS, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, GLYCOPROTEIN, LECTIN, MEMBRANE, RECEPTOR, SIGNAL-ANCHOR, TRANSMEMBRANE, SIGNALING PROTEIN, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI
2ror:A (LEU27) to (SER106) SOLUTION STRUCTURE OF THE VAV1 SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM SLP76 | SH2 DOMAIN, PROTEIN-PEPTIDE COMPLEX, PHOSPHORYLATED PEPTIDE RECOGNITION, PHOSPHOTYROSINE BINDING DOMAIN, SIGNAL TRANSDUCTION, GUANINE-NUCLEOTIDE RELEASING FACTOR, METAL- BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH3 DOMAIN, ZINC, ZINC-FINGER, SIGNALING PROTEIN, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI
2shp:A (TRP112) to (ASN200) TYROSINE PHOSPHATASE SHP-2 | TYROSINE PHOSPHATASE, INSULIN SIGNALING, SH2 PROTEIN
2shp:B (TRP112) to (ASN200) TYROSINE PHOSPHATASE SHP-2 | TYROSINE PHOSPHATASE, INSULIN SIGNALING, SH2 PROTEIN
1f2f:A (TRP148) to (HIS233) SRC SH2 THREF1TRP MUTANT | SRC, SH2 DOMAIN, SPECIFICITY SWITCH, TRANSFERASE
1r1q:A (TRP60) to (SER138) STRUCTURAL BASIS FOR DIFFERENTIAL RECOGNITION OF TYROSINE PHOSPHORYLATED SITES IN THE LINKER FOR ACTIVATION OF T CELLS (LAT) BY THE ADAPTOR PROTEIN GADS | SH2, GADS, LAT, PHOSPHOPEPTIDE, PEPTIDE BINDING PROTEIN
1r1q:B (TRP60) to (ARG135) STRUCTURAL BASIS FOR DIFFERENTIAL RECOGNITION OF TYROSINE PHOSPHORYLATED SITES IN THE LINKER FOR ACTIVATION OF T CELLS (LAT) BY THE ADAPTOR PROTEIN GADS | SH2, GADS, LAT, PHOSPHOPEPTIDE, PEPTIDE BINDING PROTEIN
1fbz:B (TRP205) to (ALA290) STRUCTURE-BASED DESIGN OF A NOVEL, OSTEOCLAST-SELECTIVE, NONPEPTIDE SRC SH2 INHIBITOR WITH IN VIVO ANTI-RESORPTIVE ACTIVITY | SH2 DOMAIN, NONPEPTIDE INHIBITOR, TRANSFERASE
2el8:A (CYS24) to (SER106) SOLUTION STRUCTURE OF THE HUMAN STAP2 SH2 DOMAIN | SH2 DOMAIN, PHOSPHOTYROSINE BINDING DOMAIN, PROTEIN TYROSINE KINASE, SIGNAL TRANSDUCTION, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, SIGNALING PROTEIN
2eo6:A (TRP25) to (GLN109) SOLUTION STRUCTURE OF THE SH2 DOMAIN FROM MOUSE B-CELL LINKER PROTEIN BLNK | SH2, CYTOPLASMIC ADAPTER PROTEIN, B-CELL ADAPTER CONTAINING SH2 DOMAIN PROTEIN, B-CELL ADAPTER CONTAINING SRC HOMOLOGY 2 DOMAIN PROTEIN, SRC HOMOLOGY 2 DOMAIN-CONTAINING LEUKOCYTE PROTEIN OF 65 KDA, SLP-65, LYMPHOCYTE ANTIGEN 57, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, SIGNALING PROTEIN
4k2r:A (TRP163) to (ALA243) STRUCTURAL BASIS FOR ACTIVATION OF ZAP-70 BY PHOSPHORYLATION OF THE SH2-KINASE LINKER | KINASE DOMAIN, SH2 DOMAIN, TRANSFERASE, ATP BINDING, CYTOPLAM
2etz:A (TRP11) to (ASN97) THE NMR MINIMIZED AVERAGE STRUCTURE OF THE ITK SH2 DOMAIN BOUND TO A PHOSPHOPEPTIDE | CIS/TRANS ISOMERIZATION, INTERLEUKIN-2 TYROSINE KINASE, ITK, T-CELL SPECIFIC KINASE, TSK, SRC HOMOLOGY 2, SH2, PROLINE, PHOSPHOTYROSINE BINDING, TRANSFERASE
1fmk:A (TRP148) to (HIS233) CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC | SRC, TYROSINE KINASE, PHOSPHORYLATION, SH2, SH3, PHOSPHOTYROSINE, PROTO-ONCOGENE, PHOSPHOTRANSFERASE
1rja:A (SER1) to (GLN84) SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THE NONRECEPTOR TYROSINE KINASE PTK6/BRK SH2 DOMAIN | HUMAN PROTEIN TYROSINE KINASE-6 (PTK6/BRK), SRC HOMOLOGY 2(SH2) DOMAIN, SOLUTION STRUCTURE, BACKBONE DYNAMICS, TRANSFERASE
1ghu:A (TRP60) to (THR138) NMR SOLUTION STRUCTURE OF GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (GRB2) SH2 DOMAIN, 24 STRUCTURES | SRC HOMOLOGY 2 DOMAIN, GRB2, SH2
1shb:A (TRP5) to (SER88) CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES | PHOSPHOTRANSFERASE
1gri:A (TRP60) to (SER139) GRB2 | SH2, SH3, SIGNAL TRANSDUCTION ADAPTOR
1gri:B (TRP60) to (ARG136) GRB2 | SH2, SH3, SIGNAL TRANSDUCTION ADAPTOR
3imj:B (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A CYCLOPROPYL-CONSTRAINED AC-PTYR-ILE-ASN-NH2 TRIPEPTIDE MIMIC | LIGAND PREORGANIZATION, PEPTIDE MIMICS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, SIGNALING PROTEIN-PSEUDOPEPTIDE LIGAND COMPLEX, SIGNALING PROTEIN-PEPTIDE COMPLEX
3in7:C (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A CYCLOPROPYL-CONSTRAINED AC-PY-Q-N-NH2 TRIPEPTIDE MIMIC | LIGAND PREORGANIZATION, PEPTIDE MIMICS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, SIGNALING PROTEIN-PSEUDOPEPTIDE LIGAND COMPLEX, SIGNALING PROTEIN-PEPTIDE COMPLEX
1tze:E (TRP60) to (ARG136) SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2) | SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR BOUND PROTEIN 2 (GRB2) SRC HOMOLOGY 2 DOMAIN (SH2), PHOSPHOTYROSYL HEPTAPEPTIC LIGAND, COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE), COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) COMPLEX
4lue:A (TRP149) to (GLY234) CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH 7-[TRANS-4-(4- METHYLPIPERAZIN-1-YL)CYCLOHEXYL]-5-(4-PHENOXYPHENYL)-7H-PYRROLO[2,3- D]PYRIMIDIN-4-AMINE (RESULTING FROM DISPLACEMENT OF SKF86002) | COCRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2huw:A (TRP60) to (ARG136) X-RAY CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN COMPLEXED TO A CONSTRAINED AND CYCLOPROPANE-DERIVED LIGAND | CYLCOPROPANE, CONTRAINED, GRB2, SH2, PREORGANIZATION,, HORMONE/GROWTH FACTOR COMPLEX
1ijr:A (TRP5) to (ALA90) CRYSTAL STRUCTURE OF LCK SH2 COMPLEXED WITH NONPEPTIDE PHOSPHOTYROSINE MIMETIC | TYROSINE-PROTEIN KINASE, TRANSFERASE/SIGNALING PROTEIN COMPLEX
4m4z:A (TRP94) to (ALA180) SH3 AND SH2 DOMAINS OF HUMAN SRC-LIKE ADAPTOR PROTEIN 2 (SLAP2) | SH3 AND SH2 DOMAINS, ADAPTOR, SIGNALING PROTEIN
3wa4:A (TRP60) to (ARG136) GRB2 SH2 DOMAIN/CD28-DERIVED PEPTIDE COMPLEX | GRB2 SH2 DOMAIN, SIGNALING PROTEIN
1ju5:A (TRP13) to (ILE106) TERNARY COMPLEX OF AN CRK SH2 DOMAIN, CRK-DERIVED PHOPHOPEPTIDE, AND ABL SH3 DOMAIN BY NMR SPECTROSCOPY | CRK, SH2, ABL, SH3, ADAPTOR PROTEIN, PHOSPHOPEPTIDE, NMR, PROTEIN BINDING/TRANSFERASE COMPLEX
5bo4:G (TRP48) to (LYS134) STRUCTURE OF SOCS2:ELONGIN C:ELONGIN B FROM DMSO-TREATED CRYSTALS | SIGNALING PROTEIN, UBIQUITIN LIGASE, SUPPRESSOR OF CYTOKINE SIGNALLING
5bo4:J (TRP48) to (LYS134) STRUCTURE OF SOCS2:ELONGIN C:ELONGIN B FROM DMSO-TREATED CRYSTALS | SIGNALING PROTEIN, UBIQUITIN LIGASE, SUPPRESSOR OF CYTOKINE SIGNALLING
5bo4:P (TRP48) to (LYS134) STRUCTURE OF SOCS2:ELONGIN C:ELONGIN B FROM DMSO-TREATED CRYSTALS | SIGNALING PROTEIN, UBIQUITIN LIGASE, SUPPRESSOR OF CYTOKINE SIGNALLING
2kno:A (TRP22) to (HIS114) NMR SOLUTION STRUCTURE OF SH2 DOMAIN OF THE HUMAN TENSIN LIKE C1 DOMAIN CONTAINING PHOSPHATASE (TENC1) | SH2 DOMAIN, TENC1, SOLUTION STRUCTURE, TENSIN2, CELL JUNCTION, CELL MEMBRANE, HYDROLASE, MEMBRANE, METAL-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, ZINC-FINGER
2lnx:A (TRP673) to (HIS750) SOLUTION STRUCTURE OF VAV2 SH2 DOMAIN | SIGNALING PROTEIN
2lqn:A (TRP14) to (LYS89) SOLUTION STRUCTURE OF CRKL | SH2, SH3, V-CRK SARCOMA VIRUS CT10 ONCOGENE HOMOLOG (AVIAN)-LIKE, SIGNALING PROTEIN
1x27:A (TRP127) to (ALA212) CRYSTAL STRUCTURE OF LCK SH2-SH3 WITH SH2 BINDING SITE OF P130CAS | LCK-CAS COMPLEX, LCK PHOSPHO-PEPTIDE COMPLEX, HIGH AFFINITY LCK-CAS COMPLEX, SIGNALING PROTEIN
1x27:B (TRP127) to (ALA212) CRYSTAL STRUCTURE OF LCK SH2-SH3 WITH SH2 BINDING SITE OF P130CAS | LCK-CAS COMPLEX, LCK PHOSPHO-PEPTIDE COMPLEX, HIGH AFFINITY LCK-CAS COMPLEX, SIGNALING PROTEIN
1x27:C (TRP127) to (ALA212) CRYSTAL STRUCTURE OF LCK SH2-SH3 WITH SH2 BINDING SITE OF P130CAS | LCK-CAS COMPLEX, LCK PHOSPHO-PEPTIDE COMPLEX, HIGH AFFINITY LCK-CAS COMPLEX, SIGNALING PROTEIN
1x27:E (TRP127) to (ALA212) CRYSTAL STRUCTURE OF LCK SH2-SH3 WITH SH2 BINDING SITE OF P130CAS | LCK-CAS COMPLEX, LCK PHOSPHO-PEPTIDE COMPLEX, HIGH AFFINITY LCK-CAS COMPLEX, SIGNALING PROTEIN
1x27:F (TRP127) to (ALA212) CRYSTAL STRUCTURE OF LCK SH2-SH3 WITH SH2 BINDING SITE OF P130CAS | LCK-CAS COMPLEX, LCK PHOSPHO-PEPTIDE COMPLEX, HIGH AFFINITY LCK-CAS COMPLEX, SIGNALING PROTEIN
2yu7:A (TRP8) to (THR95) SOLUTION STRUCTURE OF THE SHP-1 C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM NKG2A | SH2 DOMAIN, PROTEIN-PEPTIDE COMPLEX, PHOSPHORYLATED PEPTIDE RECOGNITION, PHOSPHOTYROSINE BINDING DOMAIN, SIGNAL TRANSDUCTION, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, SIGNALING PROTEIN
1lcj:A (TRP127) to (ALA212) SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL | COMPLEX (KINASE/PEPTIDE)
1lck:A (TRP127) to (ALA212) SH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA | COMPLEX (KINASE/PEPTIDE)
1lkk:A (TRP127) to (ALA212) HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE) | COMPLEX (TYROSINE KINASE/PEPTIDE)
4ohh:A (TRP6) to (HIS84) LEOPARD SYNDROME-ASSOCIATED SHP2/Q506P MUTANT | SH2 DOMAIN, PHOSPHATASE DOMAIN, HYDROLASE
4ohh:A (TRP112) to (ASN200) LEOPARD SYNDROME-ASSOCIATED SHP2/Q506P MUTANT | SH2 DOMAIN, PHOSPHATASE DOMAIN, HYDROLASE
1m61:A (PHE10) to (ASP90) CRYSTAL STRUCTURE OF THE APO SH2 DOMAINS OF ZAP-70 | APO FORM, TRANSFERASE
1m61:A (TRP163) to (LYS240) CRYSTAL STRUCTURE OF THE APO SH2 DOMAINS OF ZAP-70 | APO FORM, TRANSFERASE
5d0j:B (TRP431) to (GLN513) GRB7 SH2 WITH INHIBITOR PEPTIDE | INHIBITOR, SH2, SIGNALING PROTEIN
5d0j:D (TRP431) to (GLN513) GRB7 SH2 WITH INHIBITOR PEPTIDE | INHIBITOR, SH2, SIGNALING PROTEIN
1zfp:E (TRP60) to (ARG136) GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE | SIGNAL TRANSDUCTION, SH2 DOMAIN, PHOSPHOTYROSYL PEPTIDE, COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
5eel:F (TRP431) to (GLN513) GRB7 SH2 WITH BICYCLIC PEPTIDE INHIBITOR | SH2, INHIBITOR, BICYCLIC, SIGNALING PROTEIN-PEPTIDE COMPLEX
3m7f:A (TRP435) to (LEU518) CRYSTAL STRUCTURE OF THE NEDD4 C2/GRB10 SH2 COMPLEX | NEDD4, C2 DOMAIN, GRB10, SH2 DOMAIN, PHOSPHOPROTEIN, LIGASE, UBL CONJUGATION PATHWAY, SIGNALING PROTEIN-LIGASE COMPLEX
5ehp:A (TRP112) to (PRO201) NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP836 | PHOSPHATASE PTP INHIBITOR PTPN11 ALLOSTERIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5ehp:B (TRP112) to (PRO201) NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP836 | PHOSPHATASE PTP INHIBITOR PTPN11 ALLOSTERIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3mxc:A (TRP60) to (ARG136) STRUCTURES OF GRB2-SH2 DOMAIN AND AICD PEPTIDE COMPLEXES REVEAL A CONFORMATIONAL SWITCH AND THEIR FUNCTIONAL IMPLICATIONS. | PROTEIN-PEPTIDE COMPLEX, AICD, GRB2-SH2, PROTEIN BINDING, ALZHEIMER'S DISEASE, APP
3n7y:A (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A 20-MEMBERED MACROCYCLIC LIGAND HAVING THE SEQUENCE PYVNV | LIGAND PREORGANIZATION, MACROCYCLES, MACROCYCLIC LIGANDS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, PROTEIN BINDING- PEPTIDE COMPLEX
3n7y:B (TRP60) to (HIS135) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A 20-MEMBERED MACROCYCLIC LIGAND HAVING THE SEQUENCE PYVNV | LIGAND PREORGANIZATION, MACROCYCLES, MACROCYCLIC LIGANDS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, PROTEIN BINDING- PEPTIDE COMPLEX
3n84:B (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A 23-MEMBERED MACROCYCLIC LIGAND HAVING THE SEQUENCE PYVNVP | LIGAND PREORGANIZATION, MACROCYCLES, MACROCYCLIC LIGANDS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, PROTEIN BINDING- PEPTIDE COMPLEX
3n84:C (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A 23-MEMBERED MACROCYCLIC LIGAND HAVING THE SEQUENCE PYVNVP | LIGAND PREORGANIZATION, MACROCYCLES, MACROCYCLIC LIGANDS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, PROTEIN BINDING- PEPTIDE COMPLEX
3n84:D (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A 23-MEMBERED MACROCYCLIC LIGAND HAVING THE SEQUENCE PYVNVP | LIGAND PREORGANIZATION, MACROCYCLES, MACROCYCLIC LIGANDS, GOLGI APPARATUS, HOST-VIRUS INTERACTION, PHOSPHOPROTEIN, PROTEIN BINDING- PEPTIDE COMPLEX
4tzi:A (TRP129) to (GLN214) STRUCTURE OF UNLIGANDED LYN SH2 DOMAIN | SH2 DOMAIN, TRANSFERASE
4tzi:B (TRP129) to (GLN214) STRUCTURE OF UNLIGANDED LYN SH2 DOMAIN | SH2 DOMAIN, TRANSFERASE
4d8k:A (TRP127) to (ALA212) CRYSTAL STRUCTURE OF A SH3-SH2 DOMAINS OF A LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (LCK) FROM HOMO SAPIENS AT 2.36 A RESOLUTION | PROTEIN KINASES, SH2 DOMAIN, SH3 DOMAIN, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-BIOLOGY, PARTNERSHIP FOR T-CELL BIOLOGY, TCELL, TRANSFERASE
4u1p:A (TRP23) to (ARG108) HUMAN FYN-SH2 DOMAIN IN COMPLEX WITH A SYNTHETIC HIGH-AFFINITY PHOSPHO-PEPTIDE | SH2 DOMAIN, PROTEIN PEPTIDE INTERACTIONS, ALLOSTERY, TYROSINE PHOSPHORYLATION, FYN, KINASE, TRANSFERASE
3ov1:A (TRP60) to (ARG136) CRYSTAL STRUCTURE OF THE GRB2 SH2 DOMAIN IN COMPLEX WITH A PYXN- DERIVED TRIPEPTIDE | GRB2 SH2 DOMAIN, PHOSPHOTYROSINE BINDING, SIGNALING PROTEIN, SIGNALING PROTEIN-ANTAGONIST COMPLEX
5i6v:A (TRP112) to (ASN200) STRUCTURE OF F285S, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | SHP2, CANCER-ASSOCIATED MUTATION, INHIBITORS, HYDROLASE
5i6v:B (TRP6) to (HIS84) STRUCTURE OF F285S, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | SHP2, CANCER-ASSOCIATED MUTATION, INHIBITORS, HYDROLASE
5ibm:A (TRP6) to (HIS84) STRUCTURE OF S502P, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2 S502P, TYROSINE-PROTEIN PHOSPHATASE NON- RECEPTOR TYPE 11, HYDROLASE
5ibm:A (TRP112) to (PRO201) STRUCTURE OF S502P, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2 S502P, TYROSINE-PROTEIN PHOSPHATASE NON- RECEPTOR TYPE 11, HYDROLASE
5ibm:B (TRP112) to (ASN200) STRUCTURE OF S502P, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2 S502P, TYROSINE-PROTEIN PHOSPHATASE NON- RECEPTOR TYPE 11, HYDROLASE
5ibs:A (TRP112) to (ASN200) STRUCTURE OF E76Q, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11, HYDROLASE
5ibs:B (TRP6) to (HIS84) STRUCTURE OF E76Q, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11, HYDROLASE
5ibs:B (TRP112) to (ASN200) STRUCTURE OF E76Q, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2 | TYROSINE PHOSPHATASE SHP2, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11, HYDROLASE
4ey0:A (TRP550) to (VAL642) STRUCTURE OF TANDEM SH2 DOMAINS FROM PLCGAMMA1 | SH2 DOMAIN, PLCGAMMA SPECIFIC ARRAY, INTERACTION DOMAIN, FIBROBLAST GROWTH FACTOR RECEPTOR 1, HYDROLASE
4ey0:B (TRP550) to (VAL642) STRUCTURE OF TANDEM SH2 DOMAINS FROM PLCGAMMA1 | SH2 DOMAIN, PLCGAMMA SPECIFIC ARRAY, INTERACTION DOMAIN, FIBROBLAST GROWTH FACTOR RECEPTOR 1, HYDROLASE
4ey0:C (TRP550) to (VAL642) STRUCTURE OF TANDEM SH2 DOMAINS FROM PLCGAMMA1 | SH2 DOMAIN, PLCGAMMA SPECIFIC ARRAY, INTERACTION DOMAIN, FIBROBLAST GROWTH FACTOR RECEPTOR 1, HYDROLASE
4ey0:D (TRP550) to (VAL642) STRUCTURE OF TANDEM SH2 DOMAINS FROM PLCGAMMA1 | SH2 DOMAIN, PLCGAMMA SPECIFIC ARRAY, INTERACTION DOMAIN, FIBROBLAST GROWTH FACTOR RECEPTOR 1, HYDROLASE
2aug:B (TRP439) to (LEU522) CRYSTAL STRUCTURE OF THE GRB14 SH2 DOMAIN | PHOSPHORYLATION, SH2 DOMAIN, SIGNALING PROTEIN
1nzl:B (TRP254) to (HIS339) CRYSTAL STRUCTURE OF SRC SH2 DOMAIN BOUND TO DOUBLY PHOSPHORYLATED PEPTIDE PQPYEPYIPI | SH2 DOMAIN, PHOSPHOTYROSINE, TRANSFERASE
1o4f:A (TRP7) to (ALA93) CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073. | SH2 DOMAIN FRAGMENT APPROACH, SIGNALING PROTEIN
1bm2:A (TRP60) to (ARG136) GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791) | SH2 DOMAIN, SIGNAL TRANSDUCTION, ADAPTOR PROTEIN, RAS PATHWAY, CYCLIC PEPTIDE, HORMONE/GROWTH FACTOR COMPLEX
2ptk:A (TRP148) to (HIS233) CHICKEN SRC TYROSINE KINASE | TYROSINE-PROTEIN KINASE, SRC, SH2, SH3
2dly:A (TRP18) to (THR98) SOLUTION STRUCTURE OF THE SH2 DOMAIN OF MURINE FYN-RELATED KINASE | BRK FAMILY KINASE, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, TRANSFERASE
1f1w:A (TRP148) to (HIS233) SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN | SRC, SH2 DOMAIN, PHOSPHOPEPTIDE, SPECIFICITY SWITCH, TRANSFERASE
3hck:A (TRP6) to (GLY91) NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES | HCK, SH2, TYROSINE KINASE, SIGNAL TRANSDUCTION, TRANSFERASE
2eo3:A (TRP21) to (LYS96) SOLUTION STRUCTURE OF THE SH2 DOMAIN FROM HUMAN CRK-LIKE PROTEIN | PHOSPHORYLATION, REPEAT, SH2 DOMAIN, SH3 DOMAIN, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, SIGNALING PROTEIN
2eob:A (TRP21) to (GLU96) SOLUTION STRUCTURE OF THE SECOND SH2 DOMAIN FROM RAT PLC GAMMA-2 | SH2, PHOSPHOINOSITIDE PHOSPHOLIPASE C, PLC-GAMMA-2, PHOSPHOLIPASE C-GAMMA-2, PLC-IV, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, HYDROLASE
1g83:A (TRP149) to (ARG234) CRYSTAL STRUCTURE OF FYN SH3-SH2 | BETA BARREL, ANTIPARALLEL BETA SHEET, ALPHA HELIX, 3-10 HELIX, TRANSFERASE
1is0:A (TRP148) to (HIS233) CRYSTAL STRUCTURE OF A COMPLEX OF THE SRC SH2 DOMAIN WITH CONFORMATIONALLY CONSTRAINED PEPTIDE INHIBITOR | CONFORMATIONALY CONSTRAINED INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1is0:B (TRP148) to (HIS233) CRYSTAL STRUCTURE OF A COMPLEX OF THE SRC SH2 DOMAIN WITH CONFORMATIONALLY CONSTRAINED PEPTIDE INHIBITOR | CONFORMATIONALY CONSTRAINED INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1jyq:B (TRP60) to (ARG136) XRAY STRUCTURE OF GRB2 SH2 DOMAIN COMPLEXED WITH A HIGHLY AFFINE PHOSPHO PEPTIDE | RECEPTOR BINDING, REGULATORY, SIGNALING PROTEIN-SIGNALING PROTEIN INHIBITOR, SIGNALING PROTEIN-PEPTIDE INHIBITOR COMPLEX
2k7a:B (TRP239) to (GLN323) ENSEMBLE STRUCTURES OF THE BINARY COMPLEX BETWEEN THE SH3 AND SH2 DOMAIN OF INTERLEUKIN-2 TYROSINE KINASE. | SH3, SH2, NOVEL, CIS, ATP-BINDING, CELL MEMBRANE, KINASE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ZINC, ZINC-FINGER
1x0n:A (TRP60) to (THR138) NMR STRUCTURE OF GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH THE INHIBITOR | PEPTIDE BINDING PROTEIN
5ehr:A (TRP112) to (ASN200) NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099 | PHOSPHATASE PTP INHIBITOR PTPN11 ALLOSTERIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5ehr:B (TRP112) to (PRO201) NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099 | PHOSPHATASE PTP INHIBITOR PTPN11 ALLOSTERIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dgp:A (TRP112) to (LYS199) THE WILD-TYPE SRC HOMOLOGY 2 (SH2)-DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | HYDROLASE