2oah:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
2of0:A (LEU80) to (CYS155) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 5 | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohk:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH 1- AMINO-ISOQUINOLINE | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohl:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH 2- AMINOQUINOLINE | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohm:A (LEU80) to (CYS155) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH N~3~-BENZYLPYRIDINE-2,3-DIAMINE | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohn:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH 4- (4-FLUOROBENZYL)PIPERIDINE | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohp:A (LEU80) to (CYS155) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 3 | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohq:A (LEU80) to (GLY156) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 4 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, TRANSMEMBRANE, ZYMOGEN
2ohs:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 6B | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2oht:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 7 | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2ohu:A (LEU80) to (CYS155) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8B | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
2asi:A (ASP94) to (THR175) ASPARTIC PROTEINASE | HYDROLASE, ASPARTYL PROTEASE, GLYCOPROTEIN, ZYMOGEN
3rth:A (LEU80) to (GLY156) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 6-(2-(3,3- DIMETHYLBUT-1-YNYL)PHENYL)QUINOLIN-2-AMINE | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rtm:A (LEU80) to (CYS155) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 3-(2- AMINOQUINOLIN-3-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rtn:A (LEU80) to (CYS155) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 3-(2-AMINO-6-O- TOLYLQUINOLIN-3-YL)-N-CYCLOHEXYLPROPANAMIDE | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ru1:A (LEU80) to (CYS155) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 3-(2- AMINOQUINOLIN-3-YL)-N-(CYCLOHEXYLMETHYL)PROPANAMIDE | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rvi:A (LEU80) to (CYS155) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 2-((2-AMINO-6-O- TOLYLQUINOLIN-3-YL)METHYL)-N-(CYCLOHEXYLMETHYL)PENTANAMIDE | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1am5:A (ASP87) to (GLY157) THE CRYSTAL STRUCTURE AND PROPOSED AMINO ACID SEQUENCE OF A PEPSIN FROM ATLANTIC COD (GADUS MORHUA) | ASPARTYL PROTEASE, ACID PROTEINASE, HYDROLASE
4h1e:A (LEU141) to (ALA218) STRUCTURE OF BACE-1 BOUND TO (7AR)-6-BENZOYL-7A-(4-(3-CYANOPHENYL) THIOPHEN-2-YL)-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN- 2(3H)-IMINIUM | HYDROLASE/HYDROLASE INHIBITOR, BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h1e:B (LEU141) to (ALA218) STRUCTURE OF BACE-1 BOUND TO (7AR)-6-BENZOYL-7A-(4-(3-CYANOPHENYL) THIOPHEN-2-YL)-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN- 2(3H)-IMINIUM | HYDROLASE/HYDROLASE INHIBITOR, BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3f:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(6-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3f:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(6-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3g:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-((7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2- YL)-2-IMINO-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-6(2H)- YL)NICOTINONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3g:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-((7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2- YL)-2-IMINO-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-6(2H)- YL)NICOTINONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3i:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(3-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3i:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(3-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3j:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-FLUORO-5-(5-(2-IMINO-3-METHYL-4-OXO-6- PHENYLOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL)THIOPHEN-2-YL) BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3j:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-FLUORO-5-(5-(2-IMINO-3-METHYL-4-OXO-6- PHENYLOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL)THIOPHEN-2-YL) BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ha5:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO (S)-3-(5-(2-IMINO-1,4-DIMETHYL-6- OXOHEXAHYDROPYRIMIDIN-4-YL)THIOPHEN-3-YL)BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ha5:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO (S)-3-(5-(2-IMINO-1,4-DIMETHYL-6- OXOHEXAHYDROPYRIMIDIN-4-YL)THIOPHEN-3-YL)BENZONITRILE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2b8l:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
2b8v:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE COMPLEXED WITH L- L000430,469 | ASPARTYL PROTEASE, BACE, HYDROLASE
4wtu:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE 3-AZA-4- FLUORO-XANTHENE INHIBITOR 22 | ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p4j:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3 | BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE
2p4j:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3 | BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE
2p4j:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3 | BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE
2p4j:D (LEU80) to (GLY158) CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3 | BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE
1b5f:C (ASP87) to (ASN156) NATIVE CARDOSIN A FROM CYNARA CARDUNCULUS L. | HYDROLASE, ASPARTIC PROTEINASE
4wy1:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO COMPOUND 24B | BETA SECRETASE BACE PROTEASE
4wy6:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO COMPOUND 36 | BACE BETA SECRETASE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p83:A (LEU80) to (GLY156) POTENT AND SELECTIVE ISOPHTHALAMIDE S2 HYDROXYETHYLAMINE INHIBITOR OF BACE1 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2p83:B (LEU80) to (ALA157) POTENT AND SELECTIVE ISOPHTHALAMIDE S2 HYDROXYETHYLAMINE INHIBITOR OF BACE1 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2p83:C (LEU80) to (GLY156) POTENT AND SELECTIVE ISOPHTHALAMIDE S2 HYDROXYETHYLAMINE INHIBITOR OF BACE1 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
3exo:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 BOUND TO INHIBITOR | BETA SECRETASE, BACE 1, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
4x2l:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO COMPOUND 6 | BETA-SECRETASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bim:B (ASP87) to (ASN156) CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS | ASPARTIC PROTEINASE, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bkt:B (ASP90) to (ASN158) CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX | RENIN, ASPARTYL PROTEASE, HYDROLASE
2bks:B (ASP90) to (ARG159) CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX | HYDROLASE, ASPARTIC PROTEINASE, ASPARTYL PROTEASE, GLYCOPROTEIN, PLASMA, SIGNAL, ZYMOGEN, POLYMORPHISM
3s7l:A (LEU142) to (ALA219) PYRAZOLYL AND THIENYL AMINOHYDANTOINS AS POTENT BACE1 INHIBITORS | ASPARTYL PROTEASE, DISULFIDE BOND, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s7m:A (LEU142) to (ALA219) PYRAZOLYL AND THIENYL AMINOHYDANTOINS AS POTENT BACE1 INHIBITORS | ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4x7i:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2886721 | BACE, BETA-SECRETASE, INHIBITOR, COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4x7i:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2886721 | BACE, BETA-SECRETASE, INHIBITOR, COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ph6:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
2ph8:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
4hzt:A (LEU141) to (CYS216) STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES | ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0d:A (LEU141) to (GLY217) DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0e:A (LEU141) to (CYS216) DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0f:A (GLY142) to (GLY217) DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0g:A (LEU141) to (GLY217) DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0h:A (LEU86) to (GLY162) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS. | BACE, ASP PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0h:B (LEU86) to (ALA163) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS. | BACE, ASP PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0h:C (LEU86) to (GLY162) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS. | BACE, ASP PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0i:A (LEU86) to (GLY162) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0i:B (LEU86) to (ALA163) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0i:C (LEU86) to (GLY162) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS | BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i0z:A (LEU141) to (GLY217) STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i10:A (LEU141) to (GLY217) STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i11:A (LEU141) to (GLY217) STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES. | BACE-1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4i12:A (LEU141) to (CYS216) DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4i1c:A (LEU141) to (CYS216) DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3fkt:A (LEU100) to (ALA177) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH SPIROPIPERDINE IMINOHYDANTOIN INHIBITOR | ASPARTYL PROTEASE, BACE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3skf:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3S)-3-(ACETYLAMINO)-3-(BUTAN-2-YL)-2-OXOPYRROLIDIN-1- YL)-N-((2S,3R)-3-HYDROXY-4-((3-METHOXYBENZYL)AMINO)-1-PHENYLBUTAN-2- YL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3skf:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3S)-3-(ACETYLAMINO)-3-(BUTAN-2-YL)-2-OXOPYRROLIDIN-1- YL)-N-((2S,3R)-3-HYDROXY-4-((3-METHOXYBENZYL)AMINO)-1-PHENYLBUTAN-2- YL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3skg:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3skg:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3skg:D (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3skg:E (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2q11:A (LEU80) to (CYS155) STRUCTURE OF BACE COMPLEXED TO COMPOUND 1 | BACE INHIBITOR COMPLEX, HYDROLASE
2q11:B (LEU80) to (ALA157) STRUCTURE OF BACE COMPLEXED TO COMPOUND 1 | BACE INHIBITOR COMPLEX, HYDROLASE
2q11:C (LEU80) to (ALA157) STRUCTURE OF BACE COMPLEXED TO COMPOUND 1 | BACE INHIBITOR COMPLEX, HYDROLASE
1czi:E (ASP87) to (MET155) CHYMOSIN COMPLEX WITH THE INHIBITOR CP-113972 | ACID PROTEINASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3g6z:A (ASP95) to (ARG164) DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS | RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN
3g6z:B (ASP95) to (ARG164) DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS | RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN
3g72:A (ASP95) to (ARG164) DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS | RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN
3g72:B (ASP95) to (ASN163) DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS | RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN
2qk5:A (LEU141) to (ALA218) STRUCTURE OF BACE1 BOUND TO SCH626485 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qk5:B (LEU141) to (GLY217) STRUCTURE OF BACE1 BOUND TO SCH626485 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qmd:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH722924 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qmd:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH722924 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qmf:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH735310 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qmf:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH735310 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qmg:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH745966 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qmg:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH745966 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qp8:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH734723 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qp8:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH734723 | BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
4xxs:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH A PYRAZOLE-SUBSTITUTED TETRAHYDROPYRAN THIOAMIDINE | AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ACID ENDOPEPTIDASES, DRUG DESIGN, STRUCTURE-ACTIVITY RELATIONSHIP
4ivs:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ivt:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2qu2:A (LEU142) to (ALA219) BACE1 WITH COMPOUND 1 | BACE1, INHIBITOR, ACYLGUANIDINE, STRUCTURE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2qu3:A (LEU142) to (ALA219) BACE1 WITH COMPOUND 2 | BACE1, ACYLGUANIDINE, INHIBITOR, STRUCTURE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
1psa:A (ASP87) to (ASN158) STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1psn:A (ASP87) to (ASP158) THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN | HYDROLASE (ACID PROTEINASE)
1pso:E (ASP87) to (ASP158) THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j0p:A (LEU141) to (GLY217) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((S)-2-AMINO-4-METHYL-5,6-DIHYDRO-4H-[1,3]OXAZIN- 4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j0t:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-ETHOXY-PYRIDINE-2- CARBOXYLIC ACID [3-((R)-2-AMINO-5,5-DIFLUORO-4-METHYL-5,6-DIHYDRO-4H- [1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | POTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j0v:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5R)-2-AMINO-5-FLUORO-4-METHYL-5,6-DIHYDRO-4H- [1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j0y:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5S)-2-AMINO-5-FLUORO-4-METHYL-5,6-DIHYDRO-4H- [1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j0z:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,5R)-2-AMINO-5-FLUORO-4-FLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j17:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((S)-2-AMINO-4-DIFLUOROMETHYL-5,6-DIHYDRO-4H-[1, 3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j1c:A (LEU141) to (GLY217) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((S)-2-AMINO-5,5-DIFLUORO-4-FLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j1e:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,6S)-2-AMINO-4-FLUOROMETHYL-6-TRIFLUOROMETHYL- 5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j1f:A (LEU141) to (GLY217) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,6S)-2-AMINO-4-METHYL-6-TRIFLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j1h:A (LEU141) to (CYS216) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,6R)-2-AMINO-4-METHYL-6-TRIFLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j1i:A (LEU141) to (CYS216) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5R,6R)-2-AMINO-5-FLUORO-4-METHYL-6- TRIFLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]- AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j1k:A (ASP144) to (GLN214) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5R,6S)-2-AMINO-5-FLUORO-4-METHYL-6- TRIFLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]- AMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2qzk:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH I21 | ASPARTYL PROTEASE, BACE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2qzl:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH IXS | ASPARTYL PROTEASE, BACE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
4ybi:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2811376 | INHIBITOR, COMPLEX, ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4ybi:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2811376 | INHIBITOR, COMPLEX, ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3tpj:A (LEU80) to (ALA157) APO STRUCTURE OF BACE1 | HYDROLASE, PROTEASE, MEMAPSIN 2, BACE1
3tpl:A (LEU80) to (ALA157) APO STRUCTURE OF BACE1 | HYDROLASE, MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1
3tpl:B (LEU80) to (ALA157) APO STRUCTURE OF BACE1 | HYDROLASE, MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1
3tpl:C (LEU80) to (GLY156) APO STRUCTURE OF BACE1 | HYDROLASE, MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1
3tpp:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 COMPLEXED WITH AN INHIBITOR | MEMAPSIN 2, PROTEASE, BACE1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tpr:A (LEU80) to (GLN153) CRYSTAL STRUCTURE OF BACE1 COMPLEXED WITH AN INHIBITOR | MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3h0b:A (LEU80) to (ALA157) DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS | ASPARTYL PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3h0b:B (LEU80) to (GLY156) DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS | ASPARTYL PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3h0b:C (LEU80) to (GLY156) DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS | ASPARTYL PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
4joo:A (LEU128) to (PHE207) SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jp9:A (LEU128) to (PHE207) SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jpc:A (LEU128) to (PHE207) SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jpe:A (LEU128) to (PHE207) SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1qrp:E (ASP87) to (SER156) HUMAN PEPSIN 3A IN COMPLEX WITH A PHOSPHONATE INHIBITOR IVA-VAL-VAL- LEU(P)-(O)PHE-ALA-ALA-OME | ASPARTIC PROTEINASE, PHOSPHONATE INHIBITOR, TRANSITION STATE ANALOGUE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u6a:A (LEU80) to (ALA157) RATIONAL DESIGN AND SYNTHESIS OF AMINOPIPERAZINONES AS BETA SECRETASE (BACE) INHIBITORS | BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u6a:B (LEU80) to (PHE159) RATIONAL DESIGN AND SYNTHESIS OF AMINOPIPERAZINONES AS BETA SECRETASE (BACE) INHIBITORS | BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u6a:C (LEU80) to (PHE159) RATIONAL DESIGN AND SYNTHESIS OF AMINOPIPERAZINONES AS BETA SECRETASE (BACE) INHIBITORS | BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2v10:C (ASP95) to (ARG164) CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 9 | GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES
2v10:O (ASP95) to (TYR162) CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 9 | GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES
2v11:O (ASP95) to (ASN163) CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 6 | GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES
1fkn:A (LEU80) to (ALA157) STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1fkn:B (LEU80) to (ALA157) STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udh:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 1 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udj:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 5 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udk:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 6 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udm:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 8 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udn:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 9 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udq:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 13 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udy:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 11 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ewy:A (VAL96) to (GLY172) CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR | BACE2, ASPARTIC PROTEASE, HYDROLASE
2ewy:B (VAL96) to (GLY172) CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR | BACE2, ASPARTIC PROTEASE, HYDROLASE
2ewy:C (VAL96) to (GLY172) CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR | BACE2, ASPARTIC PROTEASE, HYDROLASE
2ewy:D (VAL96) to (GLY172) CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR | BACE2, ASPARTIC PROTEASE, HYDROLASE
4k8s:A (LEU80) to (GLY156) HYDROXYETHYLAMINE-BASED INHIBITORS OF BACE1: P1-P3 MACROCYCLIZATION CAN IMPROVE POTENCY, SELECTIVITY, AND CELL ACTIVITY | PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4k8s:B (LEU80) to (GLY156) HYDROXYETHYLAMINE-BASED INHIBITORS OF BACE1: P1-P3 MACROCYCLIZATION CAN IMPROVE POTENCY, SELECTIVITY, AND CELL ACTIVITY | PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4k8s:C (LEU80) to (ALA157) HYDROXYETHYLAMINE-BASED INHIBITORS OF BACE1: P1-P3 MACROCYCLIZATION CAN IMPROVE POTENCY, SELECTIVITY, AND CELL ACTIVITY | PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2va5:A (LEU80) to (CYS155) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8C | BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE
2va6:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 24 | BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE
4k9h:A (LEU80) to (GLY156) BACE-1 INHIBITOR COMPLEX | ASPARTIC PROTEASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4k9h:B (LEU80) to (GLY156) BACE-1 INHIBITOR COMPLEX | ASPARTIC PROTEASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f3e:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH AXQ093, A MACROCYCLIC INHIBITOR | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE
2f3e:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH AXQ093, A MACROCYCLIC INHIBITOR | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE
2f3e:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH AXQ093, A MACROCYCLIC INHIBITOR | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE
2f3f:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH BDF488, A MACROCYCLIC INHIBITOR | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE
2f3f:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH BDF488, A MACROCYCLIC INHIBITOR | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE
2f3f:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH BDF488, A MACROCYCLIC INHIBITOR | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE
1rne:A (ASP87) to (ASN156) THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR | HYDROLASE(ACID PROTEINASE)
4ke0:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 13 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ke0:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 13 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ke0:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 13 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ke1:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 19 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2fdp:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO- ETHYLENE INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
2fdp:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO- ETHYLENE INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
2fdp:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO- ETHYLENE INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
3uqp:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uqr:A (LEU80) to (GLY158) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uqr:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uqr:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uqu:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, BETA-SECRETASE, BACE1, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uqx:A (GLY81) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, BETA-SECRETASE, BACE1, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2vie:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-1-BENZYL-2-HYDROXY- 3-((1,1,5-TRIMETHYLHEXYL)AMINO)PROPYL)-3-(ETHYLAMINO)-5-(2- OXOPYRROLIDIN-1-YL)BENZAMIDE | ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2vij:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-( PHENYLMETHYL)-3-(1,2,3,4-TETRAHYDRO-1-NAPHTHALENYLAMINO) PROPYL)BENZAMIDE | ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2viy:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(PENTYLSULFONYL)BENZAMIDE | ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2viz:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(2-OXO-1-PYRROLIDINYL)-5-(PROPYLOXY) BENZAMIDE | ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2vj6:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1- PYRROLIDINYL)BENZAMIDE | MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN
2vj7:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 3-(ETHYLAMINO)-N-((1S,2R)-2- HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL) METHYL)AMINO)PROPYL)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE | ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2vj9:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)- 2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO- 1-PYRROLIDINYL)BENZAMIDE | ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2fs4:B (ASP90) to (ARG159) KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING | PROTEIN-LIGAND COMPLEXES, HYDROLASE
3hvg:A (LEU80) to (GLY156) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0 | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN
3hvg:B (LEU80) to (ALA157) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0 | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN
3hvg:C (LEU80) to (GLY156) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0 | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN
2vnn:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 7-ETHYL-N-((1S,2R)-2-HYDROXY-1- (PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-1-METHYL-3,4-DIHYDRO-1H-(1,2,5)THIADIAZEPINO(3,4,5- HI)INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE | HYDROLASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
2g1s:B (ASP90) to (ARG159) KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING | PROTEIN-LIGAND COMPLEXES, HYDROLASE
2g20:A (ASP90) to (ARG159) KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING | PROTEIN-LIGAND COMPLEXES, HYDROLASE
2g26:B (ASP90) to (ARG159) KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE "C" RING | PROTEIN-LIGAND COMPLEXES, HYDROLASE
2g27:A (ASP90) to (ASN158) KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE "C" RING | PROTEIN-LIGAND COMPLEXES, HYDROLASE
2g94:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR. | BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE
2g94:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR. | BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE
2g94:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR. | BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE
2g94:D (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR. | BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE
3veu:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-AVI326 | STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vf3:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BQQ711 | STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vg1:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A SOAKING EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3igb:A (LEU142) to (ALA219) BACE-1 WITH COMPOUND 3 | BACE-1, STRUCTURE, AMINO-IMIDAZOLES, INHIBITORS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
4l7g:A (LEU80) to (GLY156) DIETHYLAMINOSULFUR TRIFLUORIDE-MEDIATED INTRAMOLECULAR CYCLIZATION OF 2-HYDROXY-BENZYLUREAS TO FUSED BICYCLIC AMINOOXAZOLINE COMPOUNDS AND EVALUATION OF THEIR BIOCHEMICAL ACTIVITY AGAINST BETA-SECRETASE-1 (BACE1) | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4l7j:A (LEU80) to (ALA157) DIETHYLAMINOSULFUR TRIFLUORIDE-MEDIATED INTRAMOLECULAR CYCLIZATION OF 2-HYDROXY-BENZYLUREAS TO FUSED BICYCLIC AMINOOXAZOLINE COMPOUNDS AND EVALUATION OF THEIR BIOCHEMICAL ACTIVITY AGAINST BETA-SECRETASE-1 (BACE-1) | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zpe:A (LEU80) to (GLN153) BACE1 IN COMPLEX WITH 4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-8-(3- ISOPROPOXYBENZYL)-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-2-ONE | ALZHEIMER DISEASE, AMYLOID PRECURSOR PROTEIN SECRETASES, AMYLOID BETA-PEPTIDES, ASPARTIC ACID ENDOPEPTIDASES, BINDING SITES, DRUG DESIGN, TRANSGENIC, MODELS, MOLECULAR, PROTEASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zpf:A (LEU80) to (GLY156) BACE1 IN COMPLEX WITH 8-(3-((1-AMINOPROPAN-2-YL)OXY)BENZYL)-4- (CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN- 2-ONE | ALZHEIMER DISEASE, AMYLOID PRECURSOR PROTEIN SECRETASES, AMYLOID BETA-PEPTIDES, ASPARTIC ACID ENDOPEPTIDASES, BINDING SITES, DRUG DESIGN, TRANSGENIC, MODELS, MOLECULAR, PROTEASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zpg:A (LEU80) to (GLN153) BACE1 IN COMPLEX WITH 8-BENZYL-4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)- 7-METHYL-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-2-ONE | ALZHEIMER DISEASE, AMYLOID PRECURSOR PROTEIN SECRETASES, AMYLOID BETA-PEPTIDES, ASPARTIC ACID ENDOPEPTIDASES, BINDING SITES, DRUG DESIGN, MOLECULAR, PROTEASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lc7:A (LEU141) to (PHE220) AMINOOXAZOLINE INHIBITOR OF BACE-1 | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsm:A (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE FRAGMENT | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsm:B (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE FRAGMENT | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsp:A (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE INHIBITOR | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsp:B (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE INHIBITOR | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsq:A (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsq:B (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsr:A (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4zsr:B (LEU80) to (ALA157) BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR | ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3in3:A (LEU142) to (ALA219) BACE1 WITH COMPOUND 30 | BACE1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3in4:A (LEU142) to (ALA219) BACE1 WITH COMPOUND 38 | BACE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3ind:A (LEU142) to (CYS217) BACE1 WITH THE AMINOHYDANTOIN COMPOUND 29 | BACE1, XRAY, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3ine:A (LEU142) to (ALA219) BACE1 WITH THE AMINOHYDANTOIN COMPOUND S-34 | BACE1, XRAY, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3inf:A (LEU142) to (ALA219) BACE1 WITH THE AMINOHYDANTOIN COMPOUND 37 | BACE1, INHIBITOR, XRAY, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3inh:A (LEU142) to (ALA219) BACE1 WITH THE AMINOHYDANTOIN COMPOUND R-58 | BACE1, XRAY, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
1tqf:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
3ivh:A (LEU141) to (GLY217) DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS | ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2wez:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH 1-ETHYL-N-((1S,2R)-2-HYDROXY-3- (((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-4-(2-OXO-1-PYRROLIDINYL)-1H-INDOLE-6-CARBOXAMIDE | HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME
2wf0:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH 4-ETHYL-N-((1S,2R)-2-HYDROXY-1- (PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-8-(2-OXO-1-PYRROLIDINYL)-6-QUINOLINECARBOXAMIDE | HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME
2wf1:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 7-ETHYL-N-((1S,2R)-2-HYDROXY-3- (((3-(METHYLOXY)PHENYL(METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4-DIHYDRO-1H-(1,2,5)THIADIAZEPINO(3,4,5- HI)INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE | HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME
3ixj:A (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SECRETASE 1 IN COMPLEX WITH SELECTIVE BETA-SECRETASE 1 INHIBITOR | BACE, BETA SECRETASE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND, POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ixj:B (LEU128) to (GLY204) CRYSTAL STRUCTURE OF BETA-SECRETASE 1 IN COMPLEX WITH SELECTIVE BETA-SECRETASE 1 INHIBITOR | BACE, BETA SECRETASE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND, POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ixj:C (LEU128) to (GLY204) CRYSTAL STRUCTURE OF BETA-SECRETASE 1 IN COMPLEX WITH SELECTIVE BETA-SECRETASE 1 INHIBITOR | BACE, BETA SECRETASE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND, POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2wf2:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 8-ETHYL-N-((1S,2R)-2-HYDROXY-3- (((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-(1,2,5) THIADIAZEPINO(5,4,3-DE)QUINOXALINE-10-CARBOXAMIDE 2,2- DIOXIDE | HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME
2wf3:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 6-(ETHYLAMINO)-N-((1S,2R)-2- HYDROXY-3-(((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-( PHENYLMETHYL)PROPYL)-1-METHYL-1,3,4,5-TETRAHYDRO-2,1- BENZOTHIAZEPINE-8-CARBOXAMIDE 2,2-DIOXIDE | HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME
2wf4:A (LEU141) to (LEU215) HUMAN BACE-1 IN COMPLEX WITH 6-ETHYL-1-METHYL-N-((1S)-2-OXO- 1-(PHENYLMETHYL)-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL)- 1,3,4,6-TETRAHYDRO(1,2)THIAZEPINO(5,4,3-CD)INDOLE-8- CARBOXAMIDE 2,2-DIOXIDE | HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME
3ixk:A (GLY129) to (ALA205) POTENT BETA-SECRETASE 1 INHIBITOR | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND
3ixk:B (LEU128) to (GLY204) POTENT BETA-SECRETASE 1 INHIBITOR | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND
3ixk:C (ASP131) to (GLY204) POTENT BETA-SECRETASE 1 INHIBITOR | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND
1hrn:B (ASP87) to (ARG157) HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS | ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2hiz:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2hiz:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2hiz:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2hm1:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR (2) | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
3vsw:A (ASP95) to (ASN163) HUMAN RENIN IN COMPLEX WITH COMPOUND 8 | RAS, HYPERTENSION, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2wjo:A (LEU80) to (ALA157) HUMAN BACE (BETA SECRETASE) IN COMPLEX WITH CYCLOHEXANECARBOXYLIC ACID (2-(2-AM INO-6-PHENOXY-4H- QUINAZOLIN-3-YL)-2-CYCLOHEXYL-ETHYL)-AMIDE | ZYMOGEN, MEMBRANE, HYDROLASE, GLYCOPROTEIN, TRANSMEMBRANE
3vv6:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-3-METHYL-6- ((1S, 2R)-2-PHENYLCYCLOPROPYL)PYRIMIDIN-4(3H)-ONE | ASPARTYL PROTEASE, BACE, BATA SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vv7:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-6-((1S,2R)- 2-(3'-METHOXYBIPHENYL-3-YL)CYCLOPROPYL)-3-METHYLPYRIMIDIN-4(3H)-ONE | ASPARTYL PROTEASE, BASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vyf:A (ASP95) to (ASN163) HUMAN RENIN IN COMPLEX WITH INHIBITOR 9 | ASPARTYL PROTEASE, RAS, HYPERTENSION, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vyf:B (ASP95) to (ASP165) HUMAN RENIN IN COMPLEX WITH INHIBITOR 9 | ASPARTYL PROTEASE, RAS, HYPERTENSION, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lxa:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11A | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxa:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11A | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxa:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11A | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxk:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11D | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxk:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11D | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxk:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11D | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxm:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 12A | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxm:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 12A | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4lxm:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 12A | STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1uh8:A (ASP90) to (LYS160) CRYSTAL STRUCTURE OF RHIZOPUSPEPSIN AT PH 8.0 | PEPSIN, ASPARTIC PROTEINASE, HYDROLASE
2i4q:B (ASP90) to (ARG159) HUMAN RENIN/PF02342674 COMPLEX | RENIN INHIBITOR, PROTEIN-LIGAND COMPLEX, HYDROLASE
3wb4:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-3,6- DIMETHYL-6-(2-PHENYLETHYL)-3,4,5,6-TETRAHYDROPYRIMIDIN-4-ONE | PROTEASE 2, ASP2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN- 2, HYDROLASE
2irz:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, HYDROLASE
2is0:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, HYDROLASE
2xfi:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE | HYDROLASE, PROTEASE, ZYMOGEN
2xfj:A (LEU141) to (GLN214) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1- PYRROLIDINYL)BENZAMIDE | ZYMOGEN, PROTEASE, HYDROLASE
2xfk:A (LEU141) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-((METHYLSULFONYL)( PHENYL)AMINO)BENZAMIDE | ZYMOGEN, PROTEASE, HYDROLASE
4n00:A (LEU141) to (GLY217) DISCOVERY OF 7-THP CHROMANS: BACE1 INHIBITORS THAT REDUCE A-BETA IN THE CNS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1w50:A (LEU80) to (CYS155) APO STRUCTURE OF BACE (BETA SECRETASE) | ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
3zkg:B (VAL96) to (GLY172) BACE2 MUTANT APO STRUCTURE | HYDROLASE
3zki:A (VAL96) to (GLY172) BACE2 MUTANT STRUCTURE WITH LIGAND | HYDROLASE
3zkm:A (VAL96) to (GLY172) BACE2 FAB COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX, HYDROLASE, ASPARTYL PROTEASE/FAB COMPLEX
3zkm:B (VAL96) to (GLY172) BACE2 FAB COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX, HYDROLASE, ASPARTYL PROTEASE/FAB COMPLEX
3zkn:A (VAL96) to (GLY172) BACE2 FAB INHIBITOR COMPLEX | IMMUNE SYSTEM-HYDROLASE COMPLEX, FAB COMPLEX
3zkn:B (VAL96) to (GLY172) BACE2 FAB INHIBITOR COMPLEX | IMMUNE SYSTEM-HYDROLASE COMPLEX, FAB COMPLEX
3zkq:A (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY
3zks:A (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX WITH INHIBITOR | HYDROLASE-IMMUNE SYSTEM COMPLEX, INHIBITOR, NANOBODY
3zkx:A (VAL96) to (GLY172) TERNARY BACE2 XAPERONE COMPLEX | HYDROLASE
3zmg:A (LEU141) to (PHE220) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | HYDROLASE
2ntr:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO INHIBITOR | BACE, ASPARTYL PROTEASE, HYDROLASE
5clm:A (LEU80) to (ALA157) 1,4-OXAZINE BACE1 INHIBITORS | BACE1 PROTEASE INHIBITOR, ORALLY BIOAVAILABLE, BRAIN PENETRANT, PROTEROS BIOSTRUCTURES GMBH, HYDROLASE
3k5c:A (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH NB-216 | ASPARTYL PROTEINASE; ALZHEIMER'S DISEASE, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5c:B (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH NB-216 | ASPARTYL PROTEINASE; ALZHEIMER'S DISEASE, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5c:C (LEU80) to (ALA157) HUMAN BACE-1 COMPLEX WITH NB-216 | ASPARTYL PROTEINASE; ALZHEIMER'S DISEASE, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5d:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH AHM178 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3k5d:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH AHM178 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3k5d:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH AHM178 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3k5f:A (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH AYH011 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5f:B (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH AYH011 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5f:C (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH AYH011 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
1xn2:A (LEU80) to (ALA157) NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE. | BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn2:B (LEU80) to (ALA157) NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE. | BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn2:C (LEU80) to (ALA157) NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE. | BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn2:D (LEU80) to (ALA157) NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE. | BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn3:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES. | BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn3:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES. | BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn3:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES. | BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xn3:D (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES. | BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2zdz:A (ASP145) to (ALA219) X-RAY STRUCTURE OF BACE-1 IN COMPLEX WITH COMPOUND 3.B.10 | BACE, ASPARTYL PROTEASE, ACYLGUANIDINE INHIBITOR, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2ze1:A (LEU142) to (ALA219) X-RAY STRUCTURE OF BACE-1 IN COMPLEX WITH COMPOUND 6G | BACE, ASPARTYL PROTEASE, ACYLGUANIDINE INHIBITOR, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
2zhr:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH OM99-2 AT PH 5.0 | OM99-2 COMPLEX, PH 5.0, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2zhr:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH OM99-2 AT PH 5.0 | OM99-2 COMPLEX, PH 5.0, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2zhs:A (GLY81) to (ALA157) CRYSTAL STRUCTURE OF BACE1 AT PH 4.0 | PH 4.0, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zht:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 AT PH 4.5 | PH 4.5, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zhu:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 AT PH 5.0 | PH 5.0, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zhv:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BACE1 AT PH 7.0 | PH 7.0, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
1xs7:D (LEU80) to (ALA157) CRYSTAL STRUCTURE OF A CYCLOAMIDE-URETHANE-DERIVED NOVEL INHIBITOR BOUND TO HUMAN BRAIN MEMAPSIN 2 (BETA-SECRETASE). | BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, CRYSTALLOGRAPHY, HYDROLASE
2zjh:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-(1-BENZYL-PIPERIDIN-4-YL)-4-MERCAPTO-BUTYRAMIDE | BACE1, SMALL-MOLECULE INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjj:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)- AMIDE | BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjk:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE | BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjk:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE | BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjk:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE | BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjl:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-BROMO-2,3-DIMETHOXY-BENZYL)-PIPERIDIN- 4-YL]-4-MERCAPTO-BUTYRAMIDE | BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjm:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-CHLORO-2-ISOPROPOXY-3-METHOXY-BENZYL)- PIPERIDIN-4-YL]-2-(4-SULFAMOYL-PHENOXY)-ACETAMIDE | BACE, SMALL-MOLECULE INHIBITOR, FRAGMENT-BASED DISCOVERY, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
2zjn:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-CHLORO-2-ISOPROPOXY-3-METHOXY-BENZYL)- PIPERIDIN-4-YL]-2-(2-METHYL-4-SULFAMOYL-PHENOXY)-ACETAMIDE | BACE1, SMALL-MOLECULE INHIBITOR, FRAGMENT-BASED DISCOVERY, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3kmx:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH346572 | ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3kmx:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH346572 | ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3kmy:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH12472 | BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3kmy:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH12472 | BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3kn0:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH708236 | BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3kn0:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH708236 | BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
1mpp:A (ASP87) to (THR157) X-RAY ANALYSES OF ASPARTIC PROTEINASES. V. STRUCTURE AND REFINEMENT AT 2.0 ANGSTROMS RESOLUTION OF THE ASPARTIC PROTEINASE FROM MUCOR PUSILLUS | HYDROLASE(ACID PROTEINASE)
4pep:A (ASP87) to (ASN158) THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION | HYDROLASE (ACID PROTEINASE)
1ym2:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AUR200 | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ym2:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AUR200 | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ym2:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AUR200 | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ym4:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AMK640 | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ym4:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AMK640 | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ym4:C (GLY81) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AMK640 | BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kyr:A (LEU80) to (GLY156) BACE-1 IN COMPLEX WITH A NORSTATINE TYPE INHIBITOR | BACE, BETA-SECRETASE, MEMAPSIN-2, ASPARTYL PROTEASE, INHIBITOR, NORSTATINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kyr:B (LEU80) to (GLY156) BACE-1 IN COMPLEX WITH A NORSTATINE TYPE INHIBITOR | BACE, BETA-SECRETASE, MEMAPSIN-2, ASPARTYL PROTEASE, INHIBITOR, NORSTATINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kyr:C (LEU80) to (GLY156) BACE-1 IN COMPLEX WITH A NORSTATINE TYPE INHIBITOR | BACE, BETA-SECRETASE, MEMAPSIN-2, ASPARTYL PROTEASE, INHIBITOR, NORSTATINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3l38:A (LEU142) to (ALA219) BACE1 IN COMPLEX WITH THE AMINOPYRIDINE COMPOUND 44 | BETA-SECRETASE, BACE-1, AMINOPYRIDINE, INHIBITOR, ASPARTYL PROTEASE, DISULFIDE BOND, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE
3l58:A (LEU141) to (GLY217) STRUCTURE OF BACE BOUND TO SCH589432 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l58:B (LEU141) to (GLY217) STRUCTURE OF BACE BOUND TO SCH589432 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5b:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH713601 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5b:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH713601 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5c:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH723871 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5d:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH723873 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5d:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH723873 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5e:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH736062 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5e:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH736062 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
5dqc:C (LEU80) to (CYS155) CO-CRYSTAL OF BACE1 WITH COMPOUND 0211 | B-SECRETASE, INHIBITOR, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3lhg:A (LEU142) to (ALA219) BACE1 IN COMPLEX WITH THE AMINOHYDANTOIN COMPOUND 4G | INHIBITOR, AMINOHYDANTOIN, HYDROLASE
4pyv:B (ASP87) to (ARG157) CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH COMPOUND4 | RENIN INHIBITOR, 3,5-SUBSTITUTED PIPERIDINES, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4pzw:A (ASP144) to (ALA218) SYNTHESIS, CHARACTERIZATION AND PK/PD STUDIES OF A SERIES OF SPIROCYCLIC PYRANOCHROMENE BACE1 INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4pzx:A (LEU141) to (ALA218) SYNTHESIS, CHARACTERIZATION AND PK/PD STUDIES OF A SERIES OF SPIROCYCLIC PYRANOCHROMENE BACE1 INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3lnk:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH743813 | ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3lnk:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH743813 | ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3lpj:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH743641 | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE
3lpj:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH743641 | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE
3lpk:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH747123 | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE
3lpk:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH747123 | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE
4azy:A (LEU80) to (GLY156) DESIGN AND SYNTHESIS OF BACE1 INHIBITORS WITH IN VIVO BRAIN REDUCTION OF BETA-AMYLOID PEPTIDES (COMPOUND 10) | HYDROLASE, AMINOISOINDOLE, ALZHEIMER'S DISEASE
4b00:A (ASP83) to (GLY156) DESIGN AND SYNTHESIS OF BACE1 INHIBITORS WITH IN VIVO BRAIN REDUCTION OF BETA-AMYLOID PEPTIDES (COMPOUND (R)-41) | HYDROLASE, AMINOISOINDOLE, ALZHEIMER'S DISEASE
4b05:A (LEU80) to (GLY156) PRECLINICAL CHARACTERIZATION OF AZD3839, A NOVEL CLINICAL CANDIDATE BACE1 INHIBITOR FOR THE TREATMENT OF ALZHEIMER DISEASE | HYDROLASE, AMINOISOINDOLE, ALZHEIMER'S DISEASE
4b0q:A (LEU80) to (GLY156) LEAD GENERATION OF BACE1 INHIBITORS BY COUPLING NON-AMIDINE NEW WARHEADS TO A KNOWN BINDING SCAFFOLD | HYDROLASE, BACE1 INHIBITORS, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN
4b1c:A (ASP83) to (GLY156) NEW AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM RATIONAL DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN, INHIBITOR
4b1d:A (LEU80) to (ALA157) NEW AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM RATIONAL DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN, INHIBITOR
4b1e:A (ASP83) to (GLY156) NEW AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM RATIONAL DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, STRUCTURE-BASED DRUG DESIGN
4b70:A (LEU80) to (GLY156) AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, HYDROLASE INHIBITOR, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN
4b72:A (LEU80) to (GLY156) AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, HYDROLASE INHIBITOR, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN
4b77:A (ASP83) to (GLY156) AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN
5enk:A (LEU128) to (CYS203) COMPOUND 18 | BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5enm:A (LEU128) to (CYS203) COMPOUND 10 | BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4bek:A (LEU141) to (CYS216) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | HYDROLASE
4bel:A (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY
4bel:B (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY
4bfb:A (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY
4bfd:A (LEU141) to (CYS216) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | HYDROLASE
3msj:A (LEU80) to (GLY156) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH INHIBITOR | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3msj:B (LEU80) to (GLY156) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH INHIBITOR | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3msj:C (LEU80) to (GLY156) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH INHIBITOR | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3msk:A (LEU80) to (ALA157) FRAGMENT BASED DISCOVERY AND OPTIMISATION OF BACE-1 INHIBITORS | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3msl:A (LEU80) to (ALA157) FRAGMENT BASED DISCOVERY AND OPTIMISATION OF BACE-1 INHIBITORS | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5ezx:A (LEU141) to (ALA218) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH {(1R,2R)-2-[(R)-2-AMINO-4- (4-DIFLUOROMETHOXY-PHENYL)-4,5-DIHYDRO-OXAZOL-4-YL]-CYCLOPROPYL}-(5- CHLORO-PYRIDIN-3-YL)-METHANONE | PROTEASE INHIBITOR, HYDROLASE, HYDROLASE INHIBITOR COMPLEX, HYDROLASE-INHIBITOR COMPLEX
5ezz:A (LEU141) to (GLY217) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH (4S)-4-[3-(5-CHLORO-3- PYRIDYL)PHENYL]-4-[4-(DIFLUOROMETHOXY)-3-METHYL-PHENYL]-5H-OXAZOL-2- AMINE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE- INHIBITOR COMPLEX
5f00:A (LEU141) to (GLY217) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-[3-[(3-CHLORO-8- QUINOLYL)AMINO]PHENYL]-5-METHYL-2,6-DIHYDRO-1,4-OXAZIN-3-AMINE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE
5f01:A (LEU141) to (PHE220) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH (1SR,2SR)-2-((R)-2-AMINO- 5,5-DIFLUORO-4-METHYL-5,6-DIHYDRO-4H-1,3-OXAZIN-4-YL)-N-(3- CHLOROQUINOLIN-8-YL)CYCLOPROPANECARBOXAMIDE | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE
3bra:A (LEU80) to (CYS155) BACE-1 COMPLEXED WITH COMPOUND 1 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3buf:A (LEU80) to (CYS155) BACE-1 COMPLEXED WITH COMPOUND 2 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3bug:A (LEU80) to (CYS155) BACE-1 COMPLEXED WITH COMPOUND 3 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3buh:A (LEU80) to (CYS155) BACE-1 COMPLEXED WITH COMPOUND 4 | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
4r5n:A (LEU141) to (GLY217) 8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r8y:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((R)-1-(2- CYCLOPENTYLACETYL)PYRROLIDIN-3-YL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN- 2-IMINIUM | ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r8y:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((R)-1-(2- CYCLOPENTYLACETYL)PYRROLIDIN-3-YL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN- 2-IMINIUM | ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r91:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (CYCLOPENTYLAMINO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r91:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (CYCLOPENTYLAMINO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r92:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (ISONICOTINAMIDO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r92:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (ISONICOTINAMIDO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r93:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-1-METHYL-5-OXO-4- (((1S,3R)-3-(3-PHENYLUREIDO)CYCLOHEXYL)METHYL)IMIDAZOLIDIN-2-IMINIUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r93:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-1-METHYL-5-OXO-4- (((1S,3R)-3-(3-PHENYLUREIDO)CYCLOHEXYL)METHYL)IMIDAZOLIDIN-2-IMINIUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r95:A (GLY142) to (ALA218) BACE-1 IN COMPLEX WITH 2-(((1R,3S)-3-(((R)-4-(2-CYCLOHEXYLETHYL)-2- IMINIO-1-METHYL-5-OXOIMIDAZOLIDIN-4-YL)METHYL)CYCLOHEXYL)AMINO) QUINOLIN-1-IUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r95:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH 2-(((1R,3S)-3-(((R)-4-(2-CYCLOHEXYLETHYL)-2- IMINIO-1-METHYL-5-OXOIMIDAZOLIDIN-4-YL)METHYL)CYCLOHEXYL)AMINO) QUINOLIN-1-IUM | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rce:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOOXAZOLINE XANTHENE INHIBITOR 2 | ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, BRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rcf:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE 4- FLUOROXANTHENE INHIBITOR 49 | ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, BRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3cib:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH727596 | BACE1, ASPARTYL PROTEASE, HYDROLASE
3cib:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH727596 | BACE1, ASPARTYL PROTEASE, HYDROLASE
3cid:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH726222 | BACE1, ASPARTYL PROTEASE, HYDROLASE
3cid:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH726222 | BACE1, ASPARTYL PROTEASE, HYDROLASE
3ckr:A (LEU80) to (GLY158) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR | BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3ckr:C (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR | BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
4rrn:A (LEU141) to (GLY217) 8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rro:A (LEU141) to (GLY217) 8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ryg:B (ASP87) to (ARG157) RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(BENZYLSULFONYL) AMINO]PYRROLIDIN-3-YL}METHYL)-4-METHOXY-3-(3-METHOXYPROPOXY)-N- (PROPAN-2-YL)BENZAMIDE INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3d91:B (ASP95) to (ARG164) HUMAN RENIN IN COMPLEX WITH REMIKIREN | RENIN, REMIKIREN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, SECRETED, ZYMOGEN
4trw:B (LEU141) to (PHE220) STRUCTURE OF BACE1 COMPLEX WITH A SYN-HEA-TYPE INHIBITOR | HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4trz:A (LEU141) to (ALA218) STRUCTURE OF BACE1 COMPLEX WITH 2-THIOPHENYL HEA-TYPE INHIBITOR | HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ohh:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-681889 AKA N~1~-BUTYL-5-CYANO- N~3~-((1S,2R)-1-(3,5- DIFLUOROBENZYL)-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~- METHYL-1H-INDOLE-1,3- DICARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ohh:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-681889 AKA N~1~-BUTYL-5-CYANO- N~3~-((1S,2R)-1-(3,5- DIFLUOROBENZYL)-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~- METHYL-1H-INDOLE-1,3- DICARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oot:A (ASP87) to (ASN156) CRYSTAL STRUCTURE ANALYSIS OF RENIN-INDOLE-PIPERAZIN INHIBITOR COMPLEXES | RENIN HUMAN, ASPARTYL PROTEASE, RENIN INHIBITION, HYPERTENSION, HYDROLASE
3oot:B (ASP87) to (ASP158) CRYSTAL STRUCTURE ANALYSIS OF RENIN-INDOLE-PIPERAZIN INHIBITOR COMPLEXES | RENIN HUMAN, ASPARTYL PROTEASE, RENIN INHIBITION, HYPERTENSION, HYDROLASE
3ooz:A (LEU142) to (GLY218) BACE1 IN COMPLEX WITH THE AMINOHYDANTOIN COMPOUND 102 | INHIBITOR, BETA-SECRETASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d85:A (LEU82) to (GLY158) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BVI151 | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d88:A (ASP83) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXQ490 | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d89:A (LEU128) to (ALA205) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A SOAKING EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d8c:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d8c:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d8c:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3duy:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-AFJ144 | BETA-SECRETASE, BACE1, MEMAPSIN2, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3duy:B (LEU80) to (CYS155) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-AFJ144 | BETA-SECRETASE, BACE1, MEMAPSIN2, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3duy:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-AFJ144 | BETA-SECRETASE, BACE1, MEMAPSIN2, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3dv1:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-ARV999 | BETA-SECRETASE, BACE1, MEMAPSIN2, ASPARTIC PROTEASE, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3dv1:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-ARV999 | BETA-SECRETASE, BACE1, MEMAPSIN2, ASPARTIC PROTEASE, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3dv1:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-ARV999 | BETA-SECRETASE, BACE1, MEMAPSIN2, ASPARTIC PROTEASE, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3dv5:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-BAV544 | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3dv5:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-BAV544 | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3dv5:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-BAV544 | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
5hd0:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUOROPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3,4- D]PYRIMIDIN-2-IMINIUM | ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hd0:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUOROPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3,4- D]PYRIMIDIN-2-IMINIUM | ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdv:A (LEU141) to (ALA218) BACE-1 INCOMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdv:B (LEU141) to (ALA218) BACE-1 INCOMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdu:A (LEU141) to (ALA218) BACE-1 INCOMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUORO-4-METHOXYPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdu:B (LEU141) to (ALA218) BACE-1 INCOMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUORO-4-METHOXYPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdx:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(4-ETHOXY-5- FLUORO-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdx:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(4-ETHOXY-5- FLUORO-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdz:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLTHIO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hdz:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLTHIO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5he4:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,6-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5he4:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,6-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5he5:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLAMINO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5he5:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLAMINO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5he7:A (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,4-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-2-IMINO-3-METHYLOCTAHYDRO-4H- PYRROLO[3,4-D]PYRIMIDIN-4-ONE | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5he7:B (LEU141) to (ALA218) BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,4-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-2-IMINO-3-METHYLOCTAHYDRO-4H- PYRROLO[3,4-D]PYRIMIDIN-4-ONE | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dh6:A (LEU80) to (CYS155) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH (2R)-N-((2S,3R)- 1-(BENZO[D][1,3]DIOXOL-5-YL)-3-HYDROXY-4-((S)-6'-NEOPENTYL-3',4'- DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YLAMINO) BUTAN-2-YL)-2-METHOXYPROPANAMIDE | BACE-1, BETA-SECRETASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4di2:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37 | MEMAPSIN-2, ALZHEIMER'S DISEASE, PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4di2:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37 | MEMAPSIN-2, ALZHEIMER'S DISEASE, PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4di2:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37 | MEMAPSIN-2, ALZHEIMER'S DISEASE, PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dju:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5,5-DIPHENYLIMIDAZOLIDIN- 4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dju:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5,5-DIPHENYLIMIDAZOLIDIN- 4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djv:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-IMINO-5-(3'-METHOXY-[1,1'-BIPHENYL]-3- YL)-3-METHYL-5-PHENYLIMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djv:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-IMINO-5-(3'-METHOXY-[1,1'-BIPHENYL]-3- YL)-3-METHYL-5-PHENYLIMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djw:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5-PHENYL-5-(3-(PYRIDIN-3- YL)PHENYL)IMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djw:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5-PHENYL-5-(3-(PYRIDIN-3- YL)PHENYL)IMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djy:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO (R)-5-CYCLOPROPYL-2-IMINO-3-METHYL-5-(3-(5- (PROP-1-YN-1-YL)PYRIDIN-3-YL)PHENYL)IMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djy:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO (R)-5-CYCLOPROPYL-2-IMINO-3-METHYL-5-(3-(5- (PROP-1-YN-1-YL)PYRIDIN-3-YL)PHENYL)IMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dpf:A (LEU128) to (ALA205) BACE-1 IN COMPLEX WITH A HEA-MACROCYCLIC TYPE INHIBITOR | BACE1, ASP2, BACE, MACROCYCLE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dpi:A (LEU128) to (GLY204) BACE-1 IN COMPLEX WITH HEA-MACROCYCLIC INHIBITOR, MV078512 | BACE1, ASP2, BACE, MACROCYCLE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hu0:A (LEU141) to (ALA218) BACE1 IN COMPLEX WITH 4-(3-(FURAN-2-CARBOXAMIDO)PHENYL)-1-METHYL-5- OXO-4-PHENYLIMIDAZOLIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hu0:B (LEU141) to (ALA218) BACE1 IN COMPLEX WITH 4-(3-(FURAN-2-CARBOXAMIDO)PHENYL)-1-METHYL-5- OXO-4-PHENYLIMIDAZOLIDIN-2-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hu1:A (LEU141) to (ALA218) BACE1 IN COMPLEX WITH (R)-N-(3-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6- DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-4-FLUOROPHENYL)-5- FLUOROPICOLINAMIDE | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hu1:B (LEU141) to (ALA218) BACE1 IN COMPLEX WITH (R)-N-(3-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6- DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-4-FLUOROPHENYL)-5- FLUOROPICOLINAMIDE | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dus:A (LEU80) to (GLN153) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH N-((2S,3R)-1-(4- FLUOROPHENYL)-3-HYDROXY-4-((6'-NEOPENTYL-3',4'- DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDIN]-4'-YL)AMINO) BUTAN-2-YL)ACETAMIDE | HYDROLASE, ASPARTYL PROTEASE, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dv9:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dvf:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dvf:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pi5:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH BFG356 | ENZYME INHIBITOR COMPLEX, ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pi5:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH BFG356 | ENZYME INHIBITOR COMPLEX, ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pi5:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH BFG356 | ENZYME INHIBITOR COMPLEX, ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5i3v:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOQUINOLINE COMPOUND 1 | ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5i3w:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE-3- AZAXANTHENE INHIBITOR 2 | ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5i3x:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOQUINOLINE INHIBITOR 6 | ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5i3y:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOQUINOLINE INHIBITOR 9 | ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3q4b:A (ASP87) to (ARG157) CLINICALLY USEFUL ALKYL AMINE RENIN INHIBITORS | ASPARTATE PROTEASE, HYPERTENSION, RENIN EXPRESSION, RENIN INHIBITOR, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, GLYCOPROTEIN, MEMBRANE, PROTEASE, SECRETED, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ewo:A (LEU128) to (ALA205) DESIGN AND SYNTHESIS OF POTENT HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3qbh:A (LEU80) to (ALA157) STRUCTURE BASED DESIGN, SYNTHESIS AND SAR OF CYCLIC HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS | ENZYME INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qbh:B (LEU80) to (CYS155) STRUCTURE BASED DESIGN, SYNTHESIS AND SAR OF CYCLIC HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS | ENZYME INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qbh:C (LEU80) to (ALA157) STRUCTURE BASED DESIGN, SYNTHESIS AND SAR OF CYCLIC HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS | ENZYME INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qi1:A (LEU86) to (ALA163) DESIGN AND SYNTHESIS OF HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS: PRIME SIDE CHROMANE-CONTAINING INHIBITORS | ASPARTATE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fco:A (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fgx:A (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BACE1 WITH NOVEL INHIBITOR | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3r1g:B (LEU141) to (ALA218) STRUCTURE BASIS OF ALLOSTERIC INHIBITION OF BACE1 BY AN EXOSITE- BINDING ANTIBODY | ASPARTAL PROTEASE, PROTEIN BINDING
4fm7:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 14G | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fm8:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 12A | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4frj:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOOXAZOLINE XANTHENE 9L | MEMBRANE PROTEIN, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE- INHIBITOR COMPLEX
4frk:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOOXAZOLINE XANTHENE 11A | MEMBRANE PROTEIN, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE- INHIBITOR COMPLEX
4frs:A (LEU141) to (ALA218) STRUCTURE OF BACE IN COMPLEX WITH (S)-4-(3-CHLORO-5-(5-(PROP-1-YN-1- YL)PYRIDIN-3-YL)THIOPHEN-2-YL)-1,4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN- 2(1H)-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4frs:B (LEU141) to (ALA218) STRUCTURE OF BACE IN COMPLEX WITH (S)-4-(3-CHLORO-5-(5-(PROP-1-YN-1- YL)PYRIDIN-3-YL)THIOPHEN-2-YL)-1,4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN- 2(1H)-IMINIUM | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fs4:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO (S)-4-(3'-METHOXY-[1,1'-BIPHENYL]-3-YL)-1, 4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN-2(1H)-IMINIUM | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fs4:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO (S)-4-(3'-METHOXY-[1,1'-BIPHENYL]-3-YL)-1, 4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN-2(1H)-IMINIUM | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fsl:A (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4fsl:B (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4fsl:D (LEU128) to (GLY204) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4fsl:E (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4gid:A (LEU128) to (ALA205) STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR | ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gid:B (LEU128) to (ALA205) STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR | ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gid:C (LEU128) to (ALA205) STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR | ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gid:D (LEU128) to (ALA205) STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR | ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gj5:A (ASP87) to (ARG157) CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AMQ838 (COMPOUND 5) | RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gj7:B (ASP87) to (ARG157) CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-BCA079 (COMPOUND 12A) | RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gja:A (ASP87) to (ARG157) CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AYL747 (COMPOUND 5) | RENIN INHIBITOR, FRAGMENT BASED SCREENING, 3,5-DISUBSTITUTED PIPERIDINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gmi:A (LEU80) to (GLY156) BACE-1 IN COMPLEX WITH HEA-TYPE MACROCYCLIC INHIBITOR, MV078571 | BACE-1, ASP2, BACE, MACROCYCLE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5t4s:B (ASP95) to (ASN163) NOVEL APPROACH OF FRAGMENT-BASED LEAD DISCOVERY APPLIED TO RENIN INHIBITORS | PROTEIN-LIGAND COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tol:A (LEU128) to (CYS203) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 COMPLEXED WITH N- (3-((4AS,7AS)-2-AMINO-4,4A,5,6-TETRAHYDRO-7AH-FURO[2,3-D][1, 3]THIAZIN-7A-YL)-4-FLUOROPHENYL)-5-BROMO-2-PYRIDINECARBOXAMIDE | ASPARTYL PROTEASE, BACE1, KIAA1149, ASP2, FLJ90568, BACE, HSPC104, HYDROLASE
2ohr:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 6A | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, TRANSMEMBRANE, ZYMOGEN
3rsv:A (LEU80) to (ALA157) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH (R)-3-(2-AMINO-6- O-TOLYLQUINOLIN-3-YL)-N-((R)-2,2-DIMETHYLTETRAHYDRO-2H-PYRAN-4-YL)-2- METHYLPROPANAMIDE | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rsx:A (LEU80) to (ALA157) STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 6-(THIOPHEN-3- YL)QUINOLIN-2-AMINE | ASPARTIC PROTEASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3emy:A (ASP87) to (HIS157) CRYSTAL STRUCTURE OF TRICHODERMA REESEI ASPARTIC PROTEINASE COMPLEXED WITH PEPSTATIN A | TRICHODERMA REESEI, ASPARTIC PROTEINASE, ASPARTYL PROTEASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p8h:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR | ASPARTYL PROTEASE, BACE, HYDROLASE
4i0j:A (LEU141) to (GLY217) SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS | BACE ASP PROTEASE, HYDROLYSIS,, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4xkx:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE 3- AZAXANTHENE INHIBITOR 28 | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2q15:A (LEU80) to (ALA157) STRUCTURE OF BACE COMPLEXED TO COMPOUND 3A | BACE INHIBITOR COMPLEX, HYDROLASE
3g70:B (ASP95) to (ARG164) DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS | HUMAN RENIN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN
3udp:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 12 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3udr:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE WITH COMPOUND 14 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ufl:A (LEU80) to (GLY156) DISCOVERY OF PYRROLIDINE-BASED B-SECRETASE INHIBITORS: LEAD ADVANCEMENT THROUGH CONFORMATIONAL DESIGN FOR MAINTENANCE OF LIGAND BINDING EFFICIENCY | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2va7:A (LEU80) to (ALA157) X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 27 | BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE
2vkm:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE) | ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN
2vkm:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE) | ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN
2vkm:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE) | ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN
2vkm:D (LEU80) to (ALA157) CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE) | ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN
3hw1:A (LEU80) to (ALA157) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2 | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN
3hw1:B (LEU80) to (GLY156) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2 | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN
3hw1:C (LEU80) to (ALA157) STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2 | PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN
2vnm:A (ASP144) to (CYS216) HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-( PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)BENZAMIDE | HYDROLASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE
1sgz:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN. | BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE
1sgz:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN. | BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE
1sgz:C (LEU80) to (ALA157) CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN. | BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE
1sgz:D (LEU80) to (ALA157) CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN. | BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE
2g1r:B (ASP90) to (ARG159) KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING | PROTEIN-LIGAND COMPLEXES, HYDROLASE
3i25:A (LEU80) to (GLY156) POTENT BETA-SECRETASE 1 HYDROXYETHYLENE INHIBITOR | BACE, BETA-SECRETASE, INHIBITOR, ASPARTYL PROTEASE, PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, TRANSMEMBRANE, ZYMOGEN
3i25:B (LEU80) to (GLY156) POTENT BETA-SECRETASE 1 HYDROXYETHYLENE INHIBITOR | BACE, BETA-SECRETASE, INHIBITOR, ASPARTYL PROTEASE, PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, TRANSMEMBRANE, ZYMOGEN
3i25:C (LEU80) to (GLY156) POTENT BETA-SECRETASE 1 HYDROXYETHYLENE INHIBITOR | BACE, BETA-SECRETASE, INHIBITOR, ASPARTYL PROTEASE, PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, TRANSMEMBRANE, ZYMOGEN
4l7h:A (LEU80) to (ALA157) DIETHYLAMINOSULFUR TRIFLUORIDE-MEDIATED INTRAMOLECULAR CYCLIZATION OF 2-HYDROXY-BENZYLUREAS TO FUSED BICYCLIC AMINOOXAZOLINE COMPOUNDS AND EVALUATION OF THEIR BIOCHEMICAL ACTIVITY AGAINST BETA-SECRETASE-1 (BACE-1) | ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ivi:A (LEU141) to (GLY217) DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS | ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3ivi:B (LEU141) to (GLY217) DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS | ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3ivi:C (LEU141) to (GLY217) DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS | ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3vv8:A (LEU80) to (GLN153) CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-3-METHYL-6- ((1S,2R)-2-(3'-METHYLBIPHENYL-4-YL)CYCLOPROPYL)PYRIMIDIN-4(3H)-ONE | ASPARTYL PROTEASE, BASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vye:A (ASP95) to (ARG164) HUMAN RENIN IN COMPLEX WITH INHIBITOR 7 | ASPARTYL PROTEASE, RAS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wb5:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH (6S)-2-AMINO-3,6- DIMETHYL-6-[(1R,2R)-2-PHENYLCYCLOPROPYL]-3,4,5,6-TETRAHYDROPYRIMIDIN- 4-ONE | PROTEASE 2, ASP2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN- 2, HYDROLASE
2iqg:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HYDROXYETHYL SECONDARY AMINE-BASED PEPTIDOMIMETIC INHIBITOR OF HUMAN BETA-SECRETASE (BACE) | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
1w51:A (ASP83) to (CYS155) BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON- PEPTIDIC INHIBITOR | HYDROLASE/INHIBITOR, HYDROLASE/INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
3zlq:A (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX
3zlq:B (VAL96) to (GLY172) BACE2 XAPERONE COMPLEX | HYDROLASE-IMMUNE SYSTEM COMPLEX
3zov:A (LEU141) to (CYS216) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | HYDROLASE
3k1w:B (ASP95) to (ASN163) NEW CLASSES OF POTENT AND BIOAVAILABLE HUMAN RENIN INHIBITORS | RENIN, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, SECRETED, ZYMOGEN
3k5g:A (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH BJC060 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5g:B (LEU80) to (GLY156) HUMAN BACE-1 COMPLEX WITH BJC060 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
3k5g:C (LEU80) to (ALA157) HUMAN BACE-1 COMPLEX WITH BJC060 | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE
1m4h:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3 | MEMAPSIN2, BASE, ASP2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1m4h:B (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3 | MEMAPSIN2, BASE, ASP2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2zji:A (LEU80) to (CYS155) CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(2,6-DIMETHOXY-BENZYL)-PIPERIDIN-4-YL]-4-MERCAPTO-BUTYRAMIDE | BACE1, SMALL-MOLECULE INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
4acu:A (ASP83) to (GLY156) AMINOIMIDAZOLES AS BACE-1 INHIBITORS. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14 | HYDROLASE, ALZHEIMER'S DISEASE
4acx:A (LEU80) to (GLY156) AMINOIMIDAZOLES AS BACE-1 INHIBITORS. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 23 | HYDROLASE, ALZHEIMER'S DISEASE
3l3a:A (LEU142) to (ALA219) BACE-1 WITH THE AMINOPYRIDINE COMPOUND 32 | BETA-SECRETASE, BACE-1, INHIBITOR, AMINOPYRIDINE, ASPARTYL PROTEASE, DISULFIDE BOND, PROTEASE, TRANSMEMBRANE, HYDROLASE
3l59:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH710413 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l59:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH710413 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5f:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH736201 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3l5f:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH736201 | BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN
4amt:A (ASP138) to (TYR205) CRYSTAL STRUCTURE AT 2.6A OF HUMAN PRORENIN | HYDROLASE, HORMONE,
3lpi:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH745132 | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE
3lpi:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH745132 | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE
4auc:A (ASP89) to (ASP158) BOVINE CHYMOSIN IN COMPLEX WITH PEPSTATIN A | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE INHIBITOR, PEPTIDASE, INHIBITION
4b78:A (LEU80) to (ALA157) AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN | HYDROLASE, HYDROLASE INHIBITOR, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN
3n4l:B (LEU86) to (CYS161) BACE-1 IN COMPLEX WITH ELN380842 | BACE, HYDROXYETHYLAMINE, BETA SECRETASE, ALZHEIMER'S DISEASE, AD, BETA-AMYLOID PRECURSOR PROTEIN, BETA-APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3n4l:C (GLY87) to (CYS161) BACE-1 IN COMPLEX WITH ELN380842 | BACE, HYDROXYETHYLAMINE, BETA SECRETASE, ALZHEIMER'S DISEASE, AD, BETA-AMYLOID PRECURSOR PROTEIN, BETA-APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rcd:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH A 2-AMINOOXAZOLINE 4- AZAXANTHENE INHIBITOR | ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, BRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3cic:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH709583 | BACE1, ASPARTYL PROTEASE, HYDROLASE
3cic:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO SCH709583 | BACE1, ASPARTYL PROTEASE, HYDROLASE
3ckp:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR | BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3ckp:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR | BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN
3nsh:A (LEU86) to (GLY162) BACE-1 IN COMPLEX WITH ELN475957 | MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE
3nsh:B (LEU86) to (ALA163) BACE-1 IN COMPLEX WITH ELN475957 | MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE
3nsh:C (LEU86) to (GLY162) BACE-1 IN COMPLEX WITH ELN475957 | MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE
4rrs:A (LEU141) to (GLY217) 8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4try:A (LEU141) to (ALA218) STRUCTURE OF BACE1 COMPLEX WITH A HEA-TYPE INHIBITOR | HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4try:B (LEU141) to (GLY217) STRUCTURE OF BACE1 COMPLEX WITH A HEA-TYPE INHIBITOR | HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4try:C (LEU141) to (GLY217) STRUCTURE OF BACE1 COMPLEX WITH A HEA-TYPE INHIBITOR | HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ohf:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-655295 AKA N~3~-((1S,2R)-1- BENZYL-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~, N~1~-DIBUTYL-1H-INDOLE-1,3- DICARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ohf:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-655295 AKA N~3~-((1S,2R)-1- BENZYL-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~, N~1~-DIBUTYL-1H-INDOLE-1,3- DICARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dm6:A (LEU80) to (ALA157) BETA-SECRETASE 1 COMPLEXED WITH STATINE-BASED INHIBITOR | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3dm6:B (LEU80) to (ALA157) BETA-SECRETASE 1 COMPLEXED WITH STATINE-BASED INHIBITOR | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
3dm6:C (LEU80) to (ALA157) BETA-SECRETASE 1 COMPLEXED WITH STATINE-BASED INHIBITOR | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN
4d83:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d83:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d83:C (LEU80) to (GLY156) CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT | BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djx:A (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 5-(3-(5-CHLOROPYRIDIN-3-YL)PHENYL)-5- CYCLOPROPYL-2-IMINO-3-METHYLIMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djx:B (LEU141) to (ALA218) STRUCTURE OF BACE BOUND TO 5-(3-(5-CHLOROPYRIDIN-3-YL)PHENYL)-5- CYCLOPROPYL-2-IMINO-3-METHYLIMIDAZOLIDIN-4-ONE | BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5htz:A (LEU141) to (ALA218) BACE1 IN COMPLEX WITH (S)-5-(3-CHLORO-5-(5-(PROP-1-YN-1-YL)PYRIDIN-3- YL)THIOPHEN-2-YL)-2,5-DIMETHYL-1,2,4-THIADIAZINAN-3-IMINIUM 1,1- DIOXIDE | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5htz:B (LEU141) to (ALA218) BACE1 IN COMPLEX WITH (S)-5-(3-CHLORO-5-(5-(PROP-1-YN-1-YL)PYRIDIN-3- YL)THIOPHEN-2-YL)-2,5-DIMETHYL-1,2,4-THIADIAZINAN-3-IMINIUM 1,1- DIOXIDE | ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5ie1:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 3-(2-AMINO-6-(O-TOLYL) QUINOLIN-3-YL)-N-(3,3-DIMETHYLBUTYL)PROPANAMIDE | ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, HYDROLASE
4exg:A (LEU128) to (CYS203) DESIGN AND SYNTHESIS OF POTENT HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3r2f:A (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3r2f:B (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3r2f:D (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3r2f:E (LEU80) to (GLY156) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE | ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fri:A (LEU80) to (ALA157) CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH BIARYLSPIRO AMINOOXAZOLINE 6 | MEMBRANE PROTEIN, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE- INHIBITOR COMPLEX
4fse:A (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4fse:B (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4fse:D (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4fse:E (LEU128) to (ALA205) CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX
4gj6:A (ASP87) to (ARG157) CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AYZ832 (COMPOUND 6A) | RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gj6:B (ASP87) to (ASN156) CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AYZ832 (COMPOUND 6A) | RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kqf:A (LEU128) to (GLY204) (4~{S},6~{S})-4-[2,4-BIS(FLUORANYL)PHENYL]-4-METHYL-6-PYRIMIDIN-5-YL- 5,6-DIHYDRO-1,3-THIAZIN-2-AMINE (COMPOUND 12) BOUND TO BACE1 | BACE-1, SMALL MOLECULE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr8:A (LEU128) to (CYS203) (4~{S},6~{S})-4-[2,4-BIS(FLUORANYL)PHENYL]-6-(3,5-DIMETHYL-1,2-OXAZOL- 4-YL)-4-METHYL-5,6-DIHYDRO-1,3-THIAZIN-2-AMINE (COMPOUND 5) BOUND TO BACE1 | BACE-1, SMALL MOLECULE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX