Usages in wwPDB of concept: c_0412
nUsages: 603; SSE string: EEEEEHE
2oah:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
2of0:A    (LEU80) to   (CYS155)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 5  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohk:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH 1- AMINO-ISOQUINOLINE  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohl:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH 2- AMINOQUINOLINE  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohm:A    (LEU80) to   (CYS155)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH N~3~-BENZYLPYRIDINE-2,3-DIAMINE  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohn:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH 4- (4-FLUOROBENZYL)PIPERIDINE  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohp:A    (LEU80) to   (CYS155)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 3  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohq:A    (LEU80) to   (GLY156)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 4  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, TRANSMEMBRANE, ZYMOGEN 
2ohs:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 6B  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2oht:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 7  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2ohu:A    (LEU80) to   (CYS155)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8B  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
2asi:A    (ASP94) to   (THR175)  ASPARTIC PROTEINASE  |   HYDROLASE, ASPARTYL PROTEASE, GLYCOPROTEIN, ZYMOGEN 
3rth:A    (LEU80) to   (GLY156)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 6-(2-(3,3- DIMETHYLBUT-1-YNYL)PHENYL)QUINOLIN-2-AMINE  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3rtm:A    (LEU80) to   (CYS155)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 3-(2- AMINOQUINOLIN-3-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3rtn:A    (LEU80) to   (CYS155)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 3-(2-AMINO-6-O- TOLYLQUINOLIN-3-YL)-N-CYCLOHEXYLPROPANAMIDE  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ru1:A    (LEU80) to   (CYS155)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 3-(2- AMINOQUINOLIN-3-YL)-N-(CYCLOHEXYLMETHYL)PROPANAMIDE  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3rvi:A    (LEU80) to   (CYS155)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 2-((2-AMINO-6-O- TOLYLQUINOLIN-3-YL)METHYL)-N-(CYCLOHEXYLMETHYL)PENTANAMIDE  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1am5:A    (ASP87) to   (GLY157)  THE CRYSTAL STRUCTURE AND PROPOSED AMINO ACID SEQUENCE OF A PEPSIN FROM ATLANTIC COD (GADUS MORHUA)  |   ASPARTYL PROTEASE, ACID PROTEINASE, HYDROLASE 
4h1e:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE-1 BOUND TO (7AR)-6-BENZOYL-7A-(4-(3-CYANOPHENYL) THIOPHEN-2-YL)-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN- 2(3H)-IMINIUM  |   HYDROLASE/HYDROLASE INHIBITOR, BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h1e:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE-1 BOUND TO (7AR)-6-BENZOYL-7A-(4-(3-CYANOPHENYL) THIOPHEN-2-YL)-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN- 2(3H)-IMINIUM  |   HYDROLASE/HYDROLASE INHIBITOR, BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3f:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(6-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3f:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(6-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3g:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-((7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2- YL)-2-IMINO-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-6(2H)- YL)NICOTINONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3g:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-((7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2- YL)-2-IMINO-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-6(2H)- YL)NICOTINONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3i:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(3-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3i:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 3-(5-((7AR)-2-IMINO-6-(3-METHOXYPYRIDIN-2- YL)-3-METHYL-4-OXOOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL) THIOPHEN-3-YL)BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3j:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-FLUORO-5-(5-(2-IMINO-3-METHYL-4-OXO-6- PHENYLOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL)THIOPHEN-2-YL) BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4h3j:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-FLUORO-5-(5-(2-IMINO-3-METHYL-4-OXO-6- PHENYLOCTAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-7A-YL)THIOPHEN-2-YL) BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ha5:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO (S)-3-(5-(2-IMINO-1,4-DIMETHYL-6- OXOHEXAHYDROPYRIMIDIN-4-YL)THIOPHEN-3-YL)BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ha5:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO (S)-3-(5-(2-IMINO-1,4-DIMETHYL-6- OXOHEXAHYDROPYRIMIDIN-4-YL)THIOPHEN-3-YL)BENZONITRILE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2b8l:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
2b8v:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE COMPLEXED WITH L- L000430,469  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
4wtu:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE 3-AZA-4- FLUORO-XANTHENE INHIBITOR 22  |   ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2p4j:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3  |   BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE 
2p4j:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3  |   BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE 
2p4j:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3  |   BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE 
2p4j:D    (LEU80) to   (GLY158)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOND TO AN INHIBITOR WITH ISOPHTHALAMIDE DERIVATIVES AT P2-P3  |   BETA-SECRETASE, MEMAPSIN, BACE, ASP, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, STRUCTURE BASED DRUG DESIGN, HYDROLASE 
1b5f:C    (ASP87) to   (ASN156)  NATIVE CARDOSIN A FROM CYNARA CARDUNCULUS L.  |   HYDROLASE, ASPARTIC PROTEINASE 
4wy1:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO COMPOUND 24B  |   BETA SECRETASE BACE PROTEASE 
4wy6:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO COMPOUND 36  |   BACE BETA SECRETASE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2p83:A    (LEU80) to   (GLY156)  POTENT AND SELECTIVE ISOPHTHALAMIDE S2 HYDROXYETHYLAMINE INHIBITOR OF BACE1  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
2p83:B    (LEU80) to   (ALA157)  POTENT AND SELECTIVE ISOPHTHALAMIDE S2 HYDROXYETHYLAMINE INHIBITOR OF BACE1  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
2p83:C    (LEU80) to   (GLY156)  POTENT AND SELECTIVE ISOPHTHALAMIDE S2 HYDROXYETHYLAMINE INHIBITOR OF BACE1  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
3exo:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 BOUND TO INHIBITOR  |   BETA SECRETASE, BACE 1, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
4x2l:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO COMPOUND 6  |   BETA-SECRETASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1bim:B    (ASP87) to   (ASN156)  CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS  |   ASPARTIC PROTEINASE, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2bkt:B    (ASP90) to   (ASN158)  CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX  |   RENIN, ASPARTYL PROTEASE, HYDROLASE 
2bks:B    (ASP90) to   (ARG159)  CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX  |   HYDROLASE, ASPARTIC PROTEINASE, ASPARTYL PROTEASE, GLYCOPROTEIN, PLASMA, SIGNAL, ZYMOGEN, POLYMORPHISM 
3s7l:A   (LEU142) to   (ALA219)  PYRAZOLYL AND THIENYL AMINOHYDANTOINS AS POTENT BACE1 INHIBITORS  |   ASPARTYL PROTEASE, DISULFIDE BOND, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3s7m:A   (LEU142) to   (ALA219)  PYRAZOLYL AND THIENYL AMINOHYDANTOINS AS POTENT BACE1 INHIBITORS  |   ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4x7i:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2886721  |   BACE, BETA-SECRETASE, INHIBITOR, COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4x7i:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2886721  |   BACE, BETA-SECRETASE, INHIBITOR, COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2ph6:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
2ph8:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
4hzt:A   (LEU141) to   (CYS216)  STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES  |   ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0d:A   (LEU141) to   (GLY217)  DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0e:A   (LEU141) to   (CYS216)  DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0f:A   (GLY142) to   (GLY217)  DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0g:A   (LEU141) to   (GLY217)  DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0h:A    (LEU86) to   (GLY162)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS.  |   BACE, ASP PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0h:B    (LEU86) to   (ALA163)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS.  |   BACE, ASP PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0h:C    (LEU86) to   (GLY162)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS.  |   BACE, ASP PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0i:A    (LEU86) to   (GLY162)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0i:B    (LEU86) to   (ALA163)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0i:C    (LEU86) to   (GLY162)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS  |   BACE, ASPARTIC PROTEASE, HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i0z:A   (LEU141) to   (GLY217)  STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i10:A   (LEU141) to   (GLY217)  STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i11:A   (LEU141) to   (GLY217)  STRUCTURE-BASED DESIGN OF NOVEL DIHYDROISOQUINOLINE BACE-1 INHIBITORS THAT DO NOT ENGAGE THE CATALYTIC ASPARTATES.  |   BACE-1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4i12:A   (LEU141) to   (CYS216)  DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4i1c:A   (LEU141) to   (CYS216)  DESIGN AND SYNTHESIS OF THIOPHENE DIHYDROISOQUINOLINS AS NOVEL BACE-1 INHIBITORS  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3fkt:A   (LEU100) to   (ALA177)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH SPIROPIPERDINE IMINOHYDANTOIN INHIBITOR  |   ASPARTYL PROTEASE, BACE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3skf:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3S)-3-(ACETYLAMINO)-3-(BUTAN-2-YL)-2-OXOPYRROLIDIN-1- YL)-N-((2S,3R)-3-HYDROXY-4-((3-METHOXYBENZYL)AMINO)-1-PHENYLBUTAN-2- YL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3skf:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3S)-3-(ACETYLAMINO)-3-(BUTAN-2-YL)-2-OXOPYRROLIDIN-1- YL)-N-((2S,3R)-3-HYDROXY-4-((3-METHOXYBENZYL)AMINO)-1-PHENYLBUTAN-2- YL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3skg:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3skg:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3skg:D    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3skg:E    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1-PYRROLIDINYL)-N- ((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-(1,2,3,4-TETRAHYDRO-3- ISOQUINOLINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2q11:A    (LEU80) to   (CYS155)  STRUCTURE OF BACE COMPLEXED TO COMPOUND 1  |   BACE INHIBITOR COMPLEX, HYDROLASE 
2q11:B    (LEU80) to   (ALA157)  STRUCTURE OF BACE COMPLEXED TO COMPOUND 1  |   BACE INHIBITOR COMPLEX, HYDROLASE 
2q11:C    (LEU80) to   (ALA157)  STRUCTURE OF BACE COMPLEXED TO COMPOUND 1  |   BACE INHIBITOR COMPLEX, HYDROLASE 
1czi:E    (ASP87) to   (MET155)  CHYMOSIN COMPLEX WITH THE INHIBITOR CP-113972  |   ACID PROTEINASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3g6z:A    (ASP95) to   (ARG164)  DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS  |   RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN 
3g6z:B    (ASP95) to   (ARG164)  DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS  |   RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN 
3g72:A    (ASP95) to   (ARG164)  DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS  |   RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN 
3g72:B    (ASP95) to   (ASN163)  DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS  |   RENIN HUMAN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN 
2qk5:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE1 BOUND TO SCH626485  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qk5:B   (LEU141) to   (GLY217)  STRUCTURE OF BACE1 BOUND TO SCH626485  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qmd:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH722924  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qmd:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH722924  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qmf:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH735310  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qmf:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH735310  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qmg:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH745966  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qmg:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH745966  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qp8:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH734723  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qp8:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH734723  |   BACE1, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
4xxs:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH A PYRAZOLE-SUBSTITUTED TETRAHYDROPYRAN THIOAMIDINE  |   AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ACID ENDOPEPTIDASES, DRUG DESIGN, STRUCTURE-ACTIVITY RELATIONSHIP 
4ivs:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ivt:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2qu2:A   (LEU142) to   (ALA219)  BACE1 WITH COMPOUND 1  |   BACE1, INHIBITOR, ACYLGUANIDINE, STRUCTURE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2qu3:A   (LEU142) to   (ALA219)  BACE1 WITH COMPOUND 2  |   BACE1, ACYLGUANIDINE, INHIBITOR, STRUCTURE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
1psa:A    (ASP87) to   (ASN158)  STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR  |   ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1psn:A    (ASP87) to   (ASP158)  THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN  |   HYDROLASE (ACID PROTEINASE) 
1pso:E    (ASP87) to   (ASP158)  THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN  |   ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j0p:A   (LEU141) to   (GLY217)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((S)-2-AMINO-4-METHYL-5,6-DIHYDRO-4H-[1,3]OXAZIN- 4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j0t:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-ETHOXY-PYRIDINE-2- CARBOXYLIC ACID [3-((R)-2-AMINO-5,5-DIFLUORO-4-METHYL-5,6-DIHYDRO-4H- [1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   POTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j0v:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5R)-2-AMINO-5-FLUORO-4-METHYL-5,6-DIHYDRO-4H- [1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j0y:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5S)-2-AMINO-5-FLUORO-4-METHYL-5,6-DIHYDRO-4H- [1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j0z:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,5R)-2-AMINO-5-FLUORO-4-FLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j17:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((S)-2-AMINO-4-DIFLUOROMETHYL-5,6-DIHYDRO-4H-[1, 3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j1c:A   (LEU141) to   (GLY217)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((S)-2-AMINO-5,5-DIFLUORO-4-FLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j1e:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,6S)-2-AMINO-4-FLUOROMETHYL-6-TRIFLUOROMETHYL- 5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j1f:A   (LEU141) to   (GLY217)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,6S)-2-AMINO-4-METHYL-6-TRIFLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j1h:A   (LEU141) to   (CYS216)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4S,6R)-2-AMINO-4-METHYL-6-TRIFLUOROMETHYL-5,6- DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]-AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j1i:A   (LEU141) to   (CYS216)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5R,6R)-2-AMINO-5-FLUORO-4-METHYL-6- TRIFLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]- AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4j1k:A   (ASP144) to   (GLN214)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-CYANO-PYRIDINE-2- CARBOXYLIC ACID [3-((4R,5R,6S)-2-AMINO-5-FLUORO-4-METHYL-6- TRIFLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-4-FLUORO-PHENYL]- AMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2qzk:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH I21  |   ASPARTYL PROTEASE, BACE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2qzl:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH IXS  |   ASPARTYL PROTEASE, BACE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
4ybi:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2811376  |   INHIBITOR, COMPLEX, ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4ybi:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2811376  |   INHIBITOR, COMPLEX, ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
3tpj:A    (LEU80) to   (ALA157)  APO STRUCTURE OF BACE1  |   HYDROLASE, PROTEASE, MEMAPSIN 2, BACE1 
3tpl:A    (LEU80) to   (ALA157)  APO STRUCTURE OF BACE1  |   HYDROLASE, MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1 
3tpl:B    (LEU80) to   (ALA157)  APO STRUCTURE OF BACE1  |   HYDROLASE, MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1 
3tpl:C    (LEU80) to   (GLY156)  APO STRUCTURE OF BACE1  |   HYDROLASE, MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1 
3tpp:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 COMPLEXED WITH AN INHIBITOR  |   MEMAPSIN 2, PROTEASE, BACE1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3tpr:A    (LEU80) to   (GLN153)  CRYSTAL STRUCTURE OF BACE1 COMPLEXED WITH AN INHIBITOR  |   MEMAPSIN 2, PROTEASE, BETA-SECRETASE 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3h0b:A    (LEU80) to   (ALA157)  DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS  |   ASPARTYL PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3h0b:B    (LEU80) to   (GLY156)  DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS  |   ASPARTYL PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3h0b:C    (LEU80) to   (GLY156)  DISCOVERY OF AMINOHETEROCYCLES AS A NOVEL BETA-SECRETASE INHIBITOR CLASS  |   ASPARTYL PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
4joo:A   (LEU128) to   (PHE207)  SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4jp9:A   (LEU128) to   (PHE207)  SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4jpc:A   (LEU128) to   (PHE207)  SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4jpe:A   (LEU128) to   (PHE207)  SPIROCYCLIC BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1qrp:E    (ASP87) to   (SER156)  HUMAN PEPSIN 3A IN COMPLEX WITH A PHOSPHONATE INHIBITOR IVA-VAL-VAL- LEU(P)-(O)PHE-ALA-ALA-OME  |   ASPARTIC PROTEINASE, PHOSPHONATE INHIBITOR, TRANSITION STATE ANALOGUE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3u6a:A    (LEU80) to   (ALA157)  RATIONAL DESIGN AND SYNTHESIS OF AMINOPIPERAZINONES AS BETA SECRETASE (BACE) INHIBITORS  |   BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3u6a:B    (LEU80) to   (PHE159)  RATIONAL DESIGN AND SYNTHESIS OF AMINOPIPERAZINONES AS BETA SECRETASE (BACE) INHIBITORS  |   BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3u6a:C    (LEU80) to   (PHE159)  RATIONAL DESIGN AND SYNTHESIS OF AMINOPIPERAZINONES AS BETA SECRETASE (BACE) INHIBITORS  |   BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2v10:C    (ASP95) to   (ARG164)  CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 9  |   GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES 
2v10:O    (ASP95) to   (TYR162)  CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 9  |   GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES 
2v11:O    (ASP95) to   (ASN163)  CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 6  |   GLYCOPROTEIN, INHIBITOR-COMPLEX, ASPARTYL PROTEASE, ZYMOGEN, PROTEASE, HYDROLASE, POLYMORPHISM, ALTERNATIVE SPLICING, HYDROLASE(ACID PROTEINASE), CLEAVAGE ON PAIR OF BASIC RESIDUES 
1fkn:A    (LEU80) to   (ALA157)  STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1fkn:B    (LEU80) to   (ALA157)  STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udh:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 1  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udj:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 5  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udk:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 6  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udm:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 8  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udn:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 9  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udq:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 13  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udy:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 11  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2ewy:A    (VAL96) to   (GLY172)  CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR  |   BACE2, ASPARTIC PROTEASE, HYDROLASE 
2ewy:B    (VAL96) to   (GLY172)  CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR  |   BACE2, ASPARTIC PROTEASE, HYDROLASE 
2ewy:C    (VAL96) to   (GLY172)  CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR  |   BACE2, ASPARTIC PROTEASE, HYDROLASE 
2ewy:D    (VAL96) to   (GLY172)  CRYSTAL STRUCTURE OF HUMAN BACE2 IN COMPLEX WITH A HYDROXYETHYLENAMINE TRANSITION-STATE INHIBITOR  |   BACE2, ASPARTIC PROTEASE, HYDROLASE 
4k8s:A    (LEU80) to   (GLY156)  HYDROXYETHYLAMINE-BASED INHIBITORS OF BACE1: P1-P3 MACROCYCLIZATION CAN IMPROVE POTENCY, SELECTIVITY, AND CELL ACTIVITY  |   PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4k8s:B    (LEU80) to   (GLY156)  HYDROXYETHYLAMINE-BASED INHIBITORS OF BACE1: P1-P3 MACROCYCLIZATION CAN IMPROVE POTENCY, SELECTIVITY, AND CELL ACTIVITY  |   PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4k8s:C    (LEU80) to   (ALA157)  HYDROXYETHYLAMINE-BASED INHIBITORS OF BACE1: P1-P3 MACROCYCLIZATION CAN IMPROVE POTENCY, SELECTIVITY, AND CELL ACTIVITY  |   PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2va5:A    (LEU80) to   (CYS155)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 8C  |   BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE 
2va6:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 24  |   BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE 
4k9h:A    (LEU80) to   (GLY156)  BACE-1 INHIBITOR COMPLEX  |   ASPARTIC PROTEASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4k9h:B    (LEU80) to   (GLY156)  BACE-1 INHIBITOR COMPLEX  |   ASPARTIC PROTEASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2f3e:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH AXQ093, A MACROCYCLIC INHIBITOR  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE 
2f3e:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH AXQ093, A MACROCYCLIC INHIBITOR  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE 
2f3e:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH AXQ093, A MACROCYCLIC INHIBITOR  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE 
2f3f:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH BDF488, A MACROCYCLIC INHIBITOR  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE 
2f3f:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH BDF488, A MACROCYCLIC INHIBITOR  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE 
2f3f:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE BACE COMPLEX WITH BDF488, A MACROCYCLIC INHIBITOR  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, MACROCYCLIC PEPTIDOMIMETIC INHIBITOR, HYDROLASE 
1rne:A    (ASP87) to   (ASN156)  THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR  |   HYDROLASE(ACID PROTEINASE) 
4ke0:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 13  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ke0:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 13  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ke0:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 13  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ke1:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE- MACROCYCLIC INHIBITOR 19  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN (APP), HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2fdp:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO- ETHYLENE INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
2fdp:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO- ETHYLENE INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
2fdp:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO- ETHYLENE INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
3uqp:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3uqr:A    (LEU80) to   (GLY158)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3uqr:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3uqr:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3uqu:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, BETA-SECRETASE, BACE1, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3uqx:A    (GLY81) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, BETA-SECRETASE, BACE1, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2vie:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-1-BENZYL-2-HYDROXY- 3-((1,1,5-TRIMETHYLHEXYL)AMINO)PROPYL)-3-(ETHYLAMINO)-5-(2- OXOPYRROLIDIN-1-YL)BENZAMIDE  |   ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2vij:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-( PHENYLMETHYL)-3-(1,2,3,4-TETRAHYDRO-1-NAPHTHALENYLAMINO) PROPYL)BENZAMIDE  |   ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2viy:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(PENTYLSULFONYL)BENZAMIDE  |   ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2viz:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(2-OXO-1-PYRROLIDINYL)-5-(PROPYLOXY) BENZAMIDE  |   ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2vj6:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1- PYRROLIDINYL)BENZAMIDE  |   MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN 
2vj7:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 3-(ETHYLAMINO)-N-((1S,2R)-2- HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL) METHYL)AMINO)PROPYL)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE  |   ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2vj9:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)- 2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO- 1-PYRROLIDINYL)BENZAMIDE  |   ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2fs4:B    (ASP90) to   (ARG159)  KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING  |   PROTEIN-LIGAND COMPLEXES, HYDROLASE 
3hvg:A    (LEU80) to   (GLY156)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN 
3hvg:B    (LEU80) to   (ALA157)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN 
3hvg:C    (LEU80) to   (GLY156)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH EV0  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN 
2vnn:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 7-ETHYL-N-((1S,2R)-2-HYDROXY-1- (PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-1-METHYL-3,4-DIHYDRO-1H-(1,2,5)THIADIAZEPINO(3,4,5- HI)INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE  |   HYDROLASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
2g1s:B    (ASP90) to   (ARG159)  KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING  |   PROTEIN-LIGAND COMPLEXES, HYDROLASE 
2g20:A    (ASP90) to   (ARG159)  KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING  |   PROTEIN-LIGAND COMPLEXES, HYDROLASE 
2g26:B    (ASP90) to   (ARG159)  KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE "C" RING  |   PROTEIN-LIGAND COMPLEXES, HYDROLASE 
2g27:A    (ASP90) to   (ASN158)  KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE "C" RING  |   PROTEIN-LIGAND COMPLEXES, HYDROLASE 
2g94:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR.  |   BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE 
2g94:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR.  |   BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE 
2g94:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR.  |   BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE 
2g94:D    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A POTENT AND HIGHLY SELECTIVE INHIBITOR.  |   BETA SECRETASE, ALZHEIMER'S DISEASE, MEMAPSIN, BACE, ASP2, ASPARTIC PROTEASE, DRUG DESIGN, PROTEASE INHIBITOR, HYDROLASE 
3veu:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-AVI326  |   STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3vf3:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BQQ711  |   STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3vg1:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A SOAKING EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3igb:A   (LEU142) to   (ALA219)  BACE-1 WITH COMPOUND 3  |   BACE-1, STRUCTURE, AMINO-IMIDAZOLES, INHIBITORS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
4l7g:A    (LEU80) to   (GLY156)  DIETHYLAMINOSULFUR TRIFLUORIDE-MEDIATED INTRAMOLECULAR CYCLIZATION OF 2-HYDROXY-BENZYLUREAS TO FUSED BICYCLIC AMINOOXAZOLINE COMPOUNDS AND EVALUATION OF THEIR BIOCHEMICAL ACTIVITY AGAINST BETA-SECRETASE-1 (BACE1)  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4l7j:A    (LEU80) to   (ALA157)  DIETHYLAMINOSULFUR TRIFLUORIDE-MEDIATED INTRAMOLECULAR CYCLIZATION OF 2-HYDROXY-BENZYLUREAS TO FUSED BICYCLIC AMINOOXAZOLINE COMPOUNDS AND EVALUATION OF THEIR BIOCHEMICAL ACTIVITY AGAINST BETA-SECRETASE-1 (BACE-1)  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zpe:A    (LEU80) to   (GLN153)  BACE1 IN COMPLEX WITH 4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-8-(3- ISOPROPOXYBENZYL)-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-2-ONE  |   ALZHEIMER DISEASE, AMYLOID PRECURSOR PROTEIN SECRETASES, AMYLOID BETA-PEPTIDES, ASPARTIC ACID ENDOPEPTIDASES, BINDING SITES, DRUG DESIGN, TRANSGENIC, MODELS, MOLECULAR, PROTEASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zpf:A    (LEU80) to   (GLY156)  BACE1 IN COMPLEX WITH 8-(3-((1-AMINOPROPAN-2-YL)OXY)BENZYL)-4- (CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN- 2-ONE  |   ALZHEIMER DISEASE, AMYLOID PRECURSOR PROTEIN SECRETASES, AMYLOID BETA-PEPTIDES, ASPARTIC ACID ENDOPEPTIDASES, BINDING SITES, DRUG DESIGN, TRANSGENIC, MODELS, MOLECULAR, PROTEASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zpg:A    (LEU80) to   (GLN153)  BACE1 IN COMPLEX WITH 8-BENZYL-4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)- 7-METHYL-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-2-ONE  |   ALZHEIMER DISEASE, AMYLOID PRECURSOR PROTEIN SECRETASES, AMYLOID BETA-PEPTIDES, ASPARTIC ACID ENDOPEPTIDASES, BINDING SITES, DRUG DESIGN, MOLECULAR, PROTEASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4lc7:A   (LEU141) to   (PHE220)  AMINOOXAZOLINE INHIBITOR OF BACE-1  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsm:A    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE FRAGMENT  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsm:B    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE FRAGMENT  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsp:A    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE INHIBITOR  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsp:B    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE INHIBITOR  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsq:A    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsq:B    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsr:A    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4zsr:B    (LEU80) to   (ALA157)  BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR  |   ASPARTYL, PROTEASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3in3:A   (LEU142) to   (ALA219)  BACE1 WITH COMPOUND 30  |   BACE1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3in4:A   (LEU142) to   (ALA219)  BACE1 WITH COMPOUND 38  |   BACE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3ind:A   (LEU142) to   (CYS217)  BACE1 WITH THE AMINOHYDANTOIN COMPOUND 29  |   BACE1, XRAY, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3ine:A   (LEU142) to   (ALA219)  BACE1 WITH THE AMINOHYDANTOIN COMPOUND S-34  |   BACE1, XRAY, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3inf:A   (LEU142) to   (ALA219)  BACE1 WITH THE AMINOHYDANTOIN COMPOUND 37  |   BACE1, INHIBITOR, XRAY, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3inh:A   (LEU142) to   (ALA219)  BACE1 WITH THE AMINOHYDANTOIN COMPOUND R-58  |   BACE1, XRAY, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
1tqf:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
3ivh:A   (LEU141) to   (GLY217)  DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS  |   ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2wez:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH 1-ETHYL-N-((1S,2R)-2-HYDROXY-3- (((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-4-(2-OXO-1-PYRROLIDINYL)-1H-INDOLE-6-CARBOXAMIDE  |   HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME 
2wf0:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH 4-ETHYL-N-((1S,2R)-2-HYDROXY-1- (PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-8-(2-OXO-1-PYRROLIDINYL)-6-QUINOLINECARBOXAMIDE  |   HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME 
2wf1:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 7-ETHYL-N-((1S,2R)-2-HYDROXY-3- (((3-(METHYLOXY)PHENYL(METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4-DIHYDRO-1H-(1,2,5)THIADIAZEPINO(3,4,5- HI)INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE  |   HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME 
3ixj:A   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SECRETASE 1 IN COMPLEX WITH SELECTIVE BETA-SECRETASE 1 INHIBITOR  |   BACE, BETA SECRETASE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND, POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ixj:B   (LEU128) to   (GLY204)  CRYSTAL STRUCTURE OF BETA-SECRETASE 1 IN COMPLEX WITH SELECTIVE BETA-SECRETASE 1 INHIBITOR  |   BACE, BETA SECRETASE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND, POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ixj:C   (LEU128) to   (GLY204)  CRYSTAL STRUCTURE OF BETA-SECRETASE 1 IN COMPLEX WITH SELECTIVE BETA-SECRETASE 1 INHIBITOR  |   BACE, BETA SECRETASE-1, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND, POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2wf2:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 8-ETHYL-N-((1S,2R)-2-HYDROXY-3- (((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-(1,2,5) THIADIAZEPINO(5,4,3-DE)QUINOXALINE-10-CARBOXAMIDE 2,2- DIOXIDE  |   HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME 
2wf3:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 6-(ETHYLAMINO)-N-((1S,2R)-2- HYDROXY-3-(((3-(METHYLOXY)PHENYL)METHYL)AMINO)-1-( PHENYLMETHYL)PROPYL)-1-METHYL-1,3,4,5-TETRAHYDRO-2,1- BENZOTHIAZEPINE-8-CARBOXAMIDE 2,2-DIOXIDE  |   HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME 
2wf4:A   (LEU141) to   (LEU215)  HUMAN BACE-1 IN COMPLEX WITH 6-ETHYL-1-METHYL-N-((1S)-2-OXO- 1-(PHENYLMETHYL)-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL)- 1,3,4,6-TETRAHYDRO(1,2)THIAZEPINO(5,4,3-CD)INDOLE-8- CARBOXAMIDE 2,2-DIOXIDE  |   HYDROLASE, MEMAPSIN-2, POLYMORPHISM, GLYCOPROTEIN, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, TRANSMEMBRANE, BETA-SECRETASE, DISULFIDE BOND, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME 
3ixk:A   (GLY129) to   (ALA205)  POTENT BETA-SECRETASE 1 INHIBITOR  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND 
3ixk:B   (LEU128) to   (GLY204)  POTENT BETA-SECRETASE 1 INHIBITOR  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND 
3ixk:C   (ASP131) to   (GLY204)  POTENT BETA-SECRETASE 1 INHIBITOR  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, DISULFIDE BOND 
1hrn:B    (ASP87) to   (ARG157)  HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS  |   ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2hiz:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
2hiz:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
2hiz:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
2hm1:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE (BACE) IN THE PRESENCE OF AN INHIBITOR (2)  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
3vsw:A    (ASP95) to   (ASN163)  HUMAN RENIN IN COMPLEX WITH COMPOUND 8  |   RAS, HYPERTENSION, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2wjo:A    (LEU80) to   (ALA157)  HUMAN BACE (BETA SECRETASE) IN COMPLEX WITH CYCLOHEXANECARBOXYLIC ACID (2-(2-AM INO-6-PHENOXY-4H- QUINAZOLIN-3-YL)-2-CYCLOHEXYL-ETHYL)-AMIDE  |   ZYMOGEN, MEMBRANE, HYDROLASE, GLYCOPROTEIN, TRANSMEMBRANE 
3vv6:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-3-METHYL-6- ((1S, 2R)-2-PHENYLCYCLOPROPYL)PYRIMIDIN-4(3H)-ONE  |   ASPARTYL PROTEASE, BACE, BATA SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3vv7:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-6-((1S,2R)- 2-(3'-METHOXYBIPHENYL-3-YL)CYCLOPROPYL)-3-METHYLPYRIMIDIN-4(3H)-ONE  |   ASPARTYL PROTEASE, BASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3vyf:A    (ASP95) to   (ASN163)  HUMAN RENIN IN COMPLEX WITH INHIBITOR 9  |   ASPARTYL PROTEASE, RAS, HYPERTENSION, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3vyf:B    (ASP95) to   (ASP165)  HUMAN RENIN IN COMPLEX WITH INHIBITOR 9  |   ASPARTYL PROTEASE, RAS, HYPERTENSION, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4lxa:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11A  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxa:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11A  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxa:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11A  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxk:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11D  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxk:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11D  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxk:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 11D  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxm:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 12A  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxm:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 12A  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
4lxm:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH COMPOUND 12A  |   STRUCTURE-BASED DRUG DESIGN, ASPARTYL PROTEASE, MEMBRANE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
1uh8:A    (ASP90) to   (LYS160)  CRYSTAL STRUCTURE OF RHIZOPUSPEPSIN AT PH 8.0  |   PEPSIN, ASPARTIC PROTEINASE, HYDROLASE 
2i4q:B    (ASP90) to   (ARG159)  HUMAN RENIN/PF02342674 COMPLEX  |   RENIN INHIBITOR, PROTEIN-LIGAND COMPLEX, HYDROLASE 
3wb4:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-3,6- DIMETHYL-6-(2-PHENYLETHYL)-3,4,5,6-TETRAHYDROPYRIMIDIN-4-ONE  |   PROTEASE 2, ASP2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN- 2, HYDROLASE 
2irz:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, HYDROLASE 
2is0:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, HYDROLASE 
2xfi:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE  |   HYDROLASE, PROTEASE, ZYMOGEN 
2xfj:A   (LEU141) to   (GLN214)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1- PYRROLIDINYL)BENZAMIDE  |   ZYMOGEN, PROTEASE, HYDROLASE 
2xfk:A   (LEU141) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-( CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-((METHYLSULFONYL)( PHENYL)AMINO)BENZAMIDE  |   ZYMOGEN, PROTEASE, HYDROLASE 
4n00:A   (LEU141) to   (GLY217)  DISCOVERY OF 7-THP CHROMANS: BACE1 INHIBITORS THAT REDUCE A-BETA IN THE CNS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1w50:A    (LEU80) to   (CYS155)  APO STRUCTURE OF BACE (BETA SECRETASE)  |   ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
3zkg:B    (VAL96) to   (GLY172)  BACE2 MUTANT APO STRUCTURE  |   HYDROLASE 
3zki:A    (VAL96) to   (GLY172)  BACE2 MUTANT STRUCTURE WITH LIGAND  |   HYDROLASE 
3zkm:A    (VAL96) to   (GLY172)  BACE2 FAB COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, HYDROLASE, ASPARTYL PROTEASE/FAB COMPLEX 
3zkm:B    (VAL96) to   (GLY172)  BACE2 FAB COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, HYDROLASE, ASPARTYL PROTEASE/FAB COMPLEX 
3zkn:A    (VAL96) to   (GLY172)  BACE2 FAB INHIBITOR COMPLEX  |   IMMUNE SYSTEM-HYDROLASE COMPLEX, FAB COMPLEX 
3zkn:B    (VAL96) to   (GLY172)  BACE2 FAB INHIBITOR COMPLEX  |   IMMUNE SYSTEM-HYDROLASE COMPLEX, FAB COMPLEX 
3zkq:A    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY 
3zks:A    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX WITH INHIBITOR  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, INHIBITOR, NANOBODY 
3zkx:A    (VAL96) to   (GLY172)  TERNARY BACE2 XAPERONE COMPLEX  |   HYDROLASE 
3zmg:A   (LEU141) to   (PHE220)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND  |   HYDROLASE 
2ntr:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BACE-1 BOUND TO INHIBITOR  |   BACE, ASPARTYL PROTEASE, HYDROLASE 
5clm:A    (LEU80) to   (ALA157)  1,4-OXAZINE BACE1 INHIBITORS  |   BACE1 PROTEASE INHIBITOR, ORALLY BIOAVAILABLE, BRAIN PENETRANT, PROTEROS BIOSTRUCTURES GMBH, HYDROLASE 
3k5c:A    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH NB-216  |   ASPARTYL PROTEINASE; ALZHEIMER'S DISEASE, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5c:B    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH NB-216  |   ASPARTYL PROTEINASE; ALZHEIMER'S DISEASE, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5c:C    (LEU80) to   (ALA157)  HUMAN BACE-1 COMPLEX WITH NB-216  |   ASPARTYL PROTEINASE; ALZHEIMER'S DISEASE, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5d:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH AHM178  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3k5d:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH AHM178  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3k5d:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH AHM178  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, MEMBRANE, PROTEASE, TRANSMEMBRANE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3k5f:A    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH AYH011  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5f:B    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH AYH011  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5f:C    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH AYH011  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
1xn2:A    (LEU80) to   (ALA157)  NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE.  |   BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn2:B    (LEU80) to   (ALA157)  NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE.  |   BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn2:C    (LEU80) to   (ALA157)  NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE.  |   BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn2:D    (LEU80) to   (ALA157)  NEW SUBSTRATE BINDING POCKETS FOR BETA-SECRETASE.  |   BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn3:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES.  |   BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn3:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES.  |   BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn3:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES.  |   BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1xn3:D    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE BOUND TO A LONG INHIBITOR WITH ADDITIONAL UPSTREAM RESIDUES.  |   BACE, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2zdz:A   (ASP145) to   (ALA219)  X-RAY STRUCTURE OF BACE-1 IN COMPLEX WITH COMPOUND 3.B.10  |   BACE, ASPARTYL PROTEASE, ACYLGUANIDINE INHIBITOR, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2ze1:A   (LEU142) to   (ALA219)  X-RAY STRUCTURE OF BACE-1 IN COMPLEX WITH COMPOUND 6G  |   BACE, ASPARTYL PROTEASE, ACYLGUANIDINE INHIBITOR, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
2zhr:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH OM99-2 AT PH 5.0  |   OM99-2 COMPLEX, PH 5.0, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2zhr:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH OM99-2 AT PH 5.0  |   OM99-2 COMPLEX, PH 5.0, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2zhs:A    (GLY81) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 AT PH 4.0  |   PH 4.0, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zht:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 AT PH 4.5  |   PH 4.5, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zhu:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 AT PH 5.0  |   PH 5.0, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zhv:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BACE1 AT PH 7.0  |   PH 7.0, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
1xs7:D    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF A CYCLOAMIDE-URETHANE-DERIVED NOVEL INHIBITOR BOUND TO HUMAN BRAIN MEMAPSIN 2 (BETA-SECRETASE).  |   BETA SECRETASE, MEMAPSIN2, BACE, ASP2, ASPARTIC PROTEASE, ACID PROTEASE, ALZHEIMER'S DISEASE, DRUG DESIGN, CRYSTALLOGRAPHY, HYDROLASE 
2zjh:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-(1-BENZYL-PIPERIDIN-4-YL)-4-MERCAPTO-BUTYRAMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjj:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)- AMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjk:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjk:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjk:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(4-FLUORO-BENZYL)-PIPERAZINE-2-CARBOXYLIC ACID(3-MERCAPTO-PROPYL)-AMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjl:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-BROMO-2,3-DIMETHOXY-BENZYL)-PIPERIDIN- 4-YL]-4-MERCAPTO-BUTYRAMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, TETHERING, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjm:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-CHLORO-2-ISOPROPOXY-3-METHOXY-BENZYL)- PIPERIDIN-4-YL]-2-(4-SULFAMOYL-PHENOXY)-ACETAMIDE  |   BACE, SMALL-MOLECULE INHIBITOR, FRAGMENT-BASED DISCOVERY, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
2zjn:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(5-CHLORO-2-ISOPROPOXY-3-METHOXY-BENZYL)- PIPERIDIN-4-YL]-2-(2-METHYL-4-SULFAMOYL-PHENOXY)-ACETAMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, FRAGMENT-BASED DISCOVERY, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3kmx:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH346572  |   ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3kmx:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH346572  |   ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3kmy:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH12472  |   BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3kmy:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH12472  |   BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3kn0:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH708236  |   BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3kn0:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH708236  |   BACE1, ALZHEIMER'S, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
1mpp:A    (ASP87) to   (THR157)  X-RAY ANALYSES OF ASPARTIC PROTEINASES. V. STRUCTURE AND REFINEMENT AT 2.0 ANGSTROMS RESOLUTION OF THE ASPARTIC PROTEINASE FROM MUCOR PUSILLUS  |   HYDROLASE(ACID PROTEINASE) 
4pep:A    (ASP87) to   (ASN158)  THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION  |   HYDROLASE (ACID PROTEINASE) 
1ym2:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AUR200  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1ym2:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AUR200  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1ym2:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AUR200  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1ym4:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AMK640  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1ym4:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AMK640  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1ym4:C    (GLY81) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH NVP-AMK640  |   BETA-SECRETASE, MEMAPSIN2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3kyr:A    (LEU80) to   (GLY156)  BACE-1 IN COMPLEX WITH A NORSTATINE TYPE INHIBITOR  |   BACE, BETA-SECRETASE, MEMAPSIN-2, ASPARTYL PROTEASE, INHIBITOR, NORSTATINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3kyr:B    (LEU80) to   (GLY156)  BACE-1 IN COMPLEX WITH A NORSTATINE TYPE INHIBITOR  |   BACE, BETA-SECRETASE, MEMAPSIN-2, ASPARTYL PROTEASE, INHIBITOR, NORSTATINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3kyr:C    (LEU80) to   (GLY156)  BACE-1 IN COMPLEX WITH A NORSTATINE TYPE INHIBITOR  |   BACE, BETA-SECRETASE, MEMAPSIN-2, ASPARTYL PROTEASE, INHIBITOR, NORSTATINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3l38:A   (LEU142) to   (ALA219)  BACE1 IN COMPLEX WITH THE AMINOPYRIDINE COMPOUND 44  |   BETA-SECRETASE, BACE-1, AMINOPYRIDINE, INHIBITOR, ASPARTYL PROTEASE, DISULFIDE BOND, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE 
3l58:A   (LEU141) to   (GLY217)  STRUCTURE OF BACE BOUND TO SCH589432  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l58:B   (LEU141) to   (GLY217)  STRUCTURE OF BACE BOUND TO SCH589432  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5b:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH713601  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5b:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH713601  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5c:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH723871  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5d:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH723873  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5d:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH723873  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5e:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH736062  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5e:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH736062  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
5dqc:C    (LEU80) to   (CYS155)  CO-CRYSTAL OF BACE1 WITH COMPOUND 0211  |   B-SECRETASE, INHIBITOR, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3lhg:A   (LEU142) to   (ALA219)  BACE1 IN COMPLEX WITH THE AMINOHYDANTOIN COMPOUND 4G  |   INHIBITOR, AMINOHYDANTOIN, HYDROLASE 
4pyv:B    (ASP87) to   (ARG157)  CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH COMPOUND4  |   RENIN INHIBITOR, 3,5-SUBSTITUTED PIPERIDINES, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4pzw:A   (ASP144) to   (ALA218)  SYNTHESIS, CHARACTERIZATION AND PK/PD STUDIES OF A SERIES OF SPIROCYCLIC PYRANOCHROMENE BACE1 INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4pzx:A   (LEU141) to   (ALA218)  SYNTHESIS, CHARACTERIZATION AND PK/PD STUDIES OF A SERIES OF SPIROCYCLIC PYRANOCHROMENE BACE1 INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3lnk:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH743813  |   ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3lnk:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH743813  |   ALZHEIMER'S, BACE1, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3lpj:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH743641  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE 
3lpj:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH743641  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE 
3lpk:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH747123  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE 
3lpk:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH747123  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE 
4azy:A    (LEU80) to   (GLY156)  DESIGN AND SYNTHESIS OF BACE1 INHIBITORS WITH IN VIVO BRAIN REDUCTION OF BETA-AMYLOID PEPTIDES (COMPOUND 10)  |   HYDROLASE, AMINOISOINDOLE, ALZHEIMER'S DISEASE 
4b00:A    (ASP83) to   (GLY156)  DESIGN AND SYNTHESIS OF BACE1 INHIBITORS WITH IN VIVO BRAIN REDUCTION OF BETA-AMYLOID PEPTIDES (COMPOUND (R)-41)  |   HYDROLASE, AMINOISOINDOLE, ALZHEIMER'S DISEASE 
4b05:A    (LEU80) to   (GLY156)  PRECLINICAL CHARACTERIZATION OF AZD3839, A NOVEL CLINICAL CANDIDATE BACE1 INHIBITOR FOR THE TREATMENT OF ALZHEIMER DISEASE  |   HYDROLASE, AMINOISOINDOLE, ALZHEIMER'S DISEASE 
4b0q:A    (LEU80) to   (GLY156)  LEAD GENERATION OF BACE1 INHIBITORS BY COUPLING NON-AMIDINE NEW WARHEADS TO A KNOWN BINDING SCAFFOLD  |   HYDROLASE, BACE1 INHIBITORS, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN 
4b1c:A    (ASP83) to   (GLY156)  NEW AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM RATIONAL DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN, INHIBITOR 
4b1d:A    (LEU80) to   (ALA157)  NEW AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM RATIONAL DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN, INHIBITOR 
4b1e:A    (ASP83) to   (GLY156)  NEW AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM RATIONAL DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, STRUCTURE-BASED DRUG DESIGN 
4b70:A    (LEU80) to   (GLY156)  AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, HYDROLASE INHIBITOR, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN 
4b72:A    (LEU80) to   (GLY156)  AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, HYDROLASE INHIBITOR, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN 
4b77:A    (ASP83) to   (GLY156)  AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN 
5enk:A   (LEU128) to   (CYS203)  COMPOUND 18  |   BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5enm:A   (LEU128) to   (CYS203)  COMPOUND 10  |   BACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4bek:A   (LEU141) to   (CYS216)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND  |   HYDROLASE 
4bel:A    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY 
4bel:B    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY 
4bfb:A    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX, NANOBODY 
4bfd:A   (LEU141) to   (CYS216)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND  |   HYDROLASE 
3msj:A    (LEU80) to   (GLY156)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH INHIBITOR  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3msj:B    (LEU80) to   (GLY156)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH INHIBITOR  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3msj:C    (LEU80) to   (GLY156)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH INHIBITOR  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3msk:A    (LEU80) to   (ALA157)  FRAGMENT BASED DISCOVERY AND OPTIMISATION OF BACE-1 INHIBITORS  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3msl:A    (LEU80) to   (ALA157)  FRAGMENT BASED DISCOVERY AND OPTIMISATION OF BACE-1 INHIBITORS  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5ezx:A   (LEU141) to   (ALA218)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH {(1R,2R)-2-[(R)-2-AMINO-4- (4-DIFLUOROMETHOXY-PHENYL)-4,5-DIHYDRO-OXAZOL-4-YL]-CYCLOPROPYL}-(5- CHLORO-PYRIDIN-3-YL)-METHANONE  |   PROTEASE INHIBITOR, HYDROLASE, HYDROLASE INHIBITOR COMPLEX, HYDROLASE-INHIBITOR COMPLEX 
5ezz:A   (LEU141) to   (GLY217)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH (4S)-4-[3-(5-CHLORO-3- PYRIDYL)PHENYL]-4-[4-(DIFLUOROMETHOXY)-3-METHYL-PHENYL]-5H-OXAZOL-2- AMINE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE- INHIBITOR COMPLEX 
5f00:A   (LEU141) to   (GLY217)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-[3-[(3-CHLORO-8- QUINOLYL)AMINO]PHENYL]-5-METHYL-2,6-DIHYDRO-1,4-OXAZIN-3-AMINE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE 
5f01:A   (LEU141) to   (PHE220)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH (1SR,2SR)-2-((R)-2-AMINO- 5,5-DIFLUORO-4-METHYL-5,6-DIHYDRO-4H-1,3-OXAZIN-4-YL)-N-(3- CHLOROQUINOLIN-8-YL)CYCLOPROPANECARBOXAMIDE  |   PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE 
3bra:A    (LEU80) to   (CYS155)  BACE-1 COMPLEXED WITH COMPOUND 1  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3buf:A    (LEU80) to   (CYS155)  BACE-1 COMPLEXED WITH COMPOUND 2  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3bug:A    (LEU80) to   (CYS155)  BACE-1 COMPLEXED WITH COMPOUND 3  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3buh:A    (LEU80) to   (CYS155)  BACE-1 COMPLEXED WITH COMPOUND 4  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, FRAGMENT SCREEN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
4r5n:A   (LEU141) to   (GLY217)  8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r8y:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((R)-1-(2- CYCLOPENTYLACETYL)PYRROLIDIN-3-YL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN- 2-IMINIUM  |   ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r8y:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((R)-1-(2- CYCLOPENTYLACETYL)PYRROLIDIN-3-YL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN- 2-IMINIUM  |   ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r91:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (CYCLOPENTYLAMINO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r91:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (CYCLOPENTYLAMINO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r92:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (ISONICOTINAMIDO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r92:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-4-(((1S,3R)-3- (ISONICOTINAMIDO)CYCLOHEXYL)METHYL)-1-METHYL-5-OXOIMIDAZOLIDIN-2- IMINIUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r93:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-1-METHYL-5-OXO-4- (((1S,3R)-3-(3-PHENYLUREIDO)CYCLOHEXYL)METHYL)IMIDAZOLIDIN-2-IMINIUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r93:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (R)-4-(2-CYCLOHEXYLETHYL)-1-METHYL-5-OXO-4- (((1S,3R)-3-(3-PHENYLUREIDO)CYCLOHEXYL)METHYL)IMIDAZOLIDIN-2-IMINIUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r95:A   (GLY142) to   (ALA218)  BACE-1 IN COMPLEX WITH 2-(((1R,3S)-3-(((R)-4-(2-CYCLOHEXYLETHYL)-2- IMINIO-1-METHYL-5-OXOIMIDAZOLIDIN-4-YL)METHYL)CYCLOHEXYL)AMINO) QUINOLIN-1-IUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4r95:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH 2-(((1R,3S)-3-(((R)-4-(2-CYCLOHEXYLETHYL)-2- IMINIO-1-METHYL-5-OXOIMIDAZOLIDIN-4-YL)METHYL)CYCLOHEXYL)AMINO) QUINOLIN-1-IUM  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4rce:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOOXAZOLINE XANTHENE INHIBITOR 2  |   ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, BRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4rcf:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE 4- FLUOROXANTHENE INHIBITOR 49  |   ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, BRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3cib:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH727596  |   BACE1, ASPARTYL PROTEASE, HYDROLASE 
3cib:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH727596  |   BACE1, ASPARTYL PROTEASE, HYDROLASE 
3cid:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH726222  |   BACE1, ASPARTYL PROTEASE, HYDROLASE 
3cid:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH726222  |   BACE1, ASPARTYL PROTEASE, HYDROLASE 
3ckr:A    (LEU80) to   (GLY158)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR  |   BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3ckr:C    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR  |   BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
4rrn:A   (LEU141) to   (GLY217)  8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4rro:A   (LEU141) to   (GLY217)  8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ryg:B    (ASP87) to   (ARG157)  RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(BENZYLSULFONYL) AMINO]PYRROLIDIN-3-YL}METHYL)-4-METHOXY-3-(3-METHOXYPROPOXY)-N- (PROPAN-2-YL)BENZAMIDE INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3d91:B    (ASP95) to   (ARG164)  HUMAN RENIN IN COMPLEX WITH REMIKIREN  |   RENIN, REMIKIREN, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, SECRETED, ZYMOGEN 
4trw:B   (LEU141) to   (PHE220)  STRUCTURE OF BACE1 COMPLEX WITH A SYN-HEA-TYPE INHIBITOR  |   HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4trz:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE1 COMPLEX WITH 2-THIOPHENYL HEA-TYPE INHIBITOR  |   HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ohh:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-681889 AKA N~1~-BUTYL-5-CYANO- N~3~-((1S,2R)-1-(3,5- DIFLUOROBENZYL)-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~- METHYL-1H-INDOLE-1,3- DICARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ohh:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-681889 AKA N~1~-BUTYL-5-CYANO- N~3~-((1S,2R)-1-(3,5- DIFLUOROBENZYL)-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~- METHYL-1H-INDOLE-1,3- DICARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3oot:A    (ASP87) to   (ASN156)  CRYSTAL STRUCTURE ANALYSIS OF RENIN-INDOLE-PIPERAZIN INHIBITOR COMPLEXES  |   RENIN HUMAN, ASPARTYL PROTEASE, RENIN INHIBITION, HYPERTENSION, HYDROLASE 
3oot:B    (ASP87) to   (ASP158)  CRYSTAL STRUCTURE ANALYSIS OF RENIN-INDOLE-PIPERAZIN INHIBITOR COMPLEXES  |   RENIN HUMAN, ASPARTYL PROTEASE, RENIN INHIBITION, HYPERTENSION, HYDROLASE 
3ooz:A   (LEU142) to   (GLY218)  BACE1 IN COMPLEX WITH THE AMINOHYDANTOIN COMPOUND 102  |   INHIBITOR, BETA-SECRETASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d85:A    (LEU82) to   (GLY158)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BVI151  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d88:A    (ASP83) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXQ490  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d89:A   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A SOAKING EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d8c:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d8c:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d8c:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BXD552, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3duy:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-AFJ144  |   BETA-SECRETASE, BACE1, MEMAPSIN2, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3duy:B    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-AFJ144  |   BETA-SECRETASE, BACE1, MEMAPSIN2, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3duy:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-AFJ144  |   BETA-SECRETASE, BACE1, MEMAPSIN2, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3dv1:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-ARV999  |   BETA-SECRETASE, BACE1, MEMAPSIN2, ASPARTIC PROTEASE, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3dv1:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-ARV999  |   BETA-SECRETASE, BACE1, MEMAPSIN2, ASPARTIC PROTEASE, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3dv1:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-ARV999  |   BETA-SECRETASE, BACE1, MEMAPSIN2, ASPARTIC PROTEASE, ENZYME INHIBITOR COMPLEX, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3dv5:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-BAV544  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3dv5:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-BAV544  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3dv5:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA-SECRETASE IN COMPLEX WITH NVP-BAV544  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
5hd0:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUOROPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3,4- D]PYRIMIDIN-2-IMINIUM  |   ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hd0:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUOROPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3,4- D]PYRIMIDIN-2-IMINIUM  |   ASPARTYL PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdv:A   (LEU141) to   (ALA218)  BACE-1 INCOMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdv:B   (LEU141) to   (ALA218)  BACE-1 INCOMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdu:A   (LEU141) to   (ALA218)  BACE-1 INCOMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUORO-4-METHOXYPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdu:B   (LEU141) to   (ALA218)  BACE-1 INCOMPLEX WITH (7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2-YL)-6-(5- FLUORO-4-METHOXYPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdx:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(4-ETHOXY-5- FLUORO-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdx:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(4-ETHOXY-5- FLUORO-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H-PYRROLO[3, 4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdz:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLTHIO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hdz:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLTHIO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5he4:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,6-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5he4:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,6-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5he5:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLAMINO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5he5:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (7AR)-7A-(5-CYANOTHIOPHEN-2-YL)-6-(5-FLUORO-4- METHYL-6-(METHYLAMINO)PYRIMIDIN-2-YL)-3-METHYL-4-OXOOCTAHYDRO-2H- PYRROLO[3,4-D]PYRIMIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5he7:A   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,4-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-2-IMINO-3-METHYLOCTAHYDRO-4H- PYRROLO[3,4-D]PYRIMIDIN-4-ONE  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5he7:B   (LEU141) to   (ALA218)  BACE-1 IN COMPLEX WITH (4AR,7AS)-7A-(2,4-DIFLUOROPHENYL)-6-(5-FLUORO- 4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-2-IMINO-3-METHYLOCTAHYDRO-4H- PYRROLO[3,4-D]PYRIMIDIN-4-ONE  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dh6:A    (LEU80) to   (CYS155)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH (2R)-N-((2S,3R)- 1-(BENZO[D][1,3]DIOXOL-5-YL)-3-HYDROXY-4-((S)-6'-NEOPENTYL-3',4'- DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YLAMINO) BUTAN-2-YL)-2-METHOXYPROPANAMIDE  |   BACE-1, BETA-SECRETASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4di2:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37  |   MEMAPSIN-2, ALZHEIMER'S DISEASE, PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4di2:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37  |   MEMAPSIN-2, ALZHEIMER'S DISEASE, PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4di2:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37  |   MEMAPSIN-2, ALZHEIMER'S DISEASE, PROTEASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dju:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5,5-DIPHENYLIMIDAZOLIDIN- 4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dju:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5,5-DIPHENYLIMIDAZOLIDIN- 4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djv:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-IMINO-5-(3'-METHOXY-[1,1'-BIPHENYL]-3- YL)-3-METHYL-5-PHENYLIMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djv:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-IMINO-5-(3'-METHOXY-[1,1'-BIPHENYL]-3- YL)-3-METHYL-5-PHENYLIMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djw:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5-PHENYL-5-(3-(PYRIDIN-3- YL)PHENYL)IMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djw:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 2-IMINO-3-METHYL-5-PHENYL-5-(3-(PYRIDIN-3- YL)PHENYL)IMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djy:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO (R)-5-CYCLOPROPYL-2-IMINO-3-METHYL-5-(3-(5- (PROP-1-YN-1-YL)PYRIDIN-3-YL)PHENYL)IMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djy:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO (R)-5-CYCLOPROPYL-2-IMINO-3-METHYL-5-(3-(5- (PROP-1-YN-1-YL)PYRIDIN-3-YL)PHENYL)IMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dpf:A   (LEU128) to   (ALA205)  BACE-1 IN COMPLEX WITH A HEA-MACROCYCLIC TYPE INHIBITOR  |   BACE1, ASP2, BACE, MACROCYCLE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dpi:A   (LEU128) to   (GLY204)  BACE-1 IN COMPLEX WITH HEA-MACROCYCLIC INHIBITOR, MV078512  |   BACE1, ASP2, BACE, MACROCYCLE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hu0:A   (LEU141) to   (ALA218)  BACE1 IN COMPLEX WITH 4-(3-(FURAN-2-CARBOXAMIDO)PHENYL)-1-METHYL-5- OXO-4-PHENYLIMIDAZOLIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hu0:B   (LEU141) to   (ALA218)  BACE1 IN COMPLEX WITH 4-(3-(FURAN-2-CARBOXAMIDO)PHENYL)-1-METHYL-5- OXO-4-PHENYLIMIDAZOLIDIN-2-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hu1:A   (LEU141) to   (ALA218)  BACE1 IN COMPLEX WITH (R)-N-(3-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6- DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-4-FLUOROPHENYL)-5- FLUOROPICOLINAMIDE  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5hu1:B   (LEU141) to   (ALA218)  BACE1 IN COMPLEX WITH (R)-N-(3-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6- DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-4-FLUOROPHENYL)-5- FLUOROPICOLINAMIDE  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dus:A    (LEU80) to   (GLN153)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH N-((2S,3R)-1-(4- FLUOROPHENYL)-3-HYDROXY-4-((6'-NEOPENTYL-3',4'- DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDIN]-4'-YL)AMINO) BUTAN-2-YL)ACETAMIDE  |   HYDROLASE, ASPARTYL PROTEASE, APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dv9:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dvf:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4dvf:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3pi5:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH BFG356  |   ENZYME INHIBITOR COMPLEX, ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3pi5:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH BFG356  |   ENZYME INHIBITOR COMPLEX, ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3pi5:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH BFG356  |   ENZYME INHIBITOR COMPLEX, ASPARTIC PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5i3v:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOQUINOLINE COMPOUND 1  |   ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5i3w:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE-3- AZAXANTHENE INHIBITOR 2  |   ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5i3x:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOQUINOLINE INHIBITOR 6  |   ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5i3y:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOQUINOLINE INHIBITOR 9  |   ASPARTIC PROTEASE, AMYLOID PRECURSOR PROTEIN, ALZHEIMER'S DISEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3q4b:A    (ASP87) to   (ARG157)  CLINICALLY USEFUL ALKYL AMINE RENIN INHIBITORS  |   ASPARTATE PROTEASE, HYPERTENSION, RENIN EXPRESSION, RENIN INHIBITOR, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, GLYCOPROTEIN, MEMBRANE, PROTEASE, SECRETED, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4ewo:A   (LEU128) to   (ALA205)  DESIGN AND SYNTHESIS OF POTENT HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
3qbh:A    (LEU80) to   (ALA157)  STRUCTURE BASED DESIGN, SYNTHESIS AND SAR OF CYCLIC HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS  |   ENZYME INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3qbh:B    (LEU80) to   (CYS155)  STRUCTURE BASED DESIGN, SYNTHESIS AND SAR OF CYCLIC HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS  |   ENZYME INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3qbh:C    (LEU80) to   (ALA157)  STRUCTURE BASED DESIGN, SYNTHESIS AND SAR OF CYCLIC HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS  |   ENZYME INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3qi1:A    (LEU86) to   (ALA163)  DESIGN AND SYNTHESIS OF HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS: PRIME SIDE CHROMANE-CONTAINING INHIBITORS  |   ASPARTATE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fco:A   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BACE1 WITH ITS INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fgx:A   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BACE1 WITH NOVEL INHIBITOR  |   HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3r1g:B   (LEU141) to   (ALA218)  STRUCTURE BASIS OF ALLOSTERIC INHIBITION OF BACE1 BY AN EXOSITE- BINDING ANTIBODY  |   ASPARTAL PROTEASE, PROTEIN BINDING 
4fm7:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 14G  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fm8:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 12A  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4frj:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOOXAZOLINE XANTHENE 9L  |   MEMBRANE PROTEIN, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE- INHIBITOR COMPLEX 
4frk:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH AMINOOXAZOLINE XANTHENE 11A  |   MEMBRANE PROTEIN, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE- INHIBITOR COMPLEX 
4frs:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE IN COMPLEX WITH (S)-4-(3-CHLORO-5-(5-(PROP-1-YN-1- YL)PYRIDIN-3-YL)THIOPHEN-2-YL)-1,4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN- 2(1H)-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4frs:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE IN COMPLEX WITH (S)-4-(3-CHLORO-5-(5-(PROP-1-YN-1- YL)PYRIDIN-3-YL)THIOPHEN-2-YL)-1,4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN- 2(1H)-IMINIUM  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fs4:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO (S)-4-(3'-METHOXY-[1,1'-BIPHENYL]-3-YL)-1, 4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN-2(1H)-IMINIUM  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fs4:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO (S)-4-(3'-METHOXY-[1,1'-BIPHENYL]-3-YL)-1, 4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN-2(1H)-IMINIUM  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fsl:A   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4fsl:B   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4fsl:D   (LEU128) to   (GLY204)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4fsl:E   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-DB-MUT) COMPLEX WITH N-(N-(4- ACETAMIDO-3-CHLORO-5-METHYLBENZYL) CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5-METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4gid:A   (LEU128) to   (ALA205)  STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gid:B   (LEU128) to   (ALA205)  STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gid:C   (LEU128) to   (ALA205)  STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gid:D   (LEU128) to   (ALA205)  STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTIC PROTEASE, BETA SECRETASE, APP, BACE, A-BETA, PROTEASE, MEMAPSIN, ALZHEIMER, DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gj5:A    (ASP87) to   (ARG157)  CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AMQ838 (COMPOUND 5)  |   RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gj7:B    (ASP87) to   (ARG157)  CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-BCA079 (COMPOUND 12A)  |   RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gja:A    (ASP87) to   (ARG157)  CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AYL747 (COMPOUND 5)  |   RENIN INHIBITOR, FRAGMENT BASED SCREENING, 3,5-DISUBSTITUTED PIPERIDINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gmi:A    (LEU80) to   (GLY156)  BACE-1 IN COMPLEX WITH HEA-TYPE MACROCYCLIC INHIBITOR, MV078571  |   BACE-1, ASP2, BACE, MACROCYCLE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5t4s:B    (ASP95) to   (ASN163)  NOVEL APPROACH OF FRAGMENT-BASED LEAD DISCOVERY APPLIED TO RENIN INHIBITORS  |   PROTEIN-LIGAND COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5tol:A   (LEU128) to   (CYS203)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 COMPLEXED WITH N- (3-((4AS,7AS)-2-AMINO-4,4A,5,6-TETRAHYDRO-7AH-FURO[2,3-D][1, 3]THIAZIN-7A-YL)-4-FLUOROPHENYL)-5-BROMO-2-PYRIDINECARBOXAMIDE  |   ASPARTYL PROTEASE, BACE1, KIAA1149, ASP2, FLJ90568, BACE, HSPC104, HYDROLASE 
2ohr:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 6A  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, TRANSMEMBRANE, ZYMOGEN 
3rsv:A    (LEU80) to   (ALA157)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH (R)-3-(2-AMINO-6- O-TOLYLQUINOLIN-3-YL)-N-((R)-2,2-DIMETHYLTETRAHYDRO-2H-PYRAN-4-YL)-2- METHYLPROPANAMIDE  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3rsx:A    (LEU80) to   (ALA157)  STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH 6-(THIOPHEN-3- YL)QUINOLIN-2-AMINE  |   ASPARTIC PROTEASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3emy:A    (ASP87) to   (HIS157)  CRYSTAL STRUCTURE OF TRICHODERMA REESEI ASPARTIC PROTEINASE COMPLEXED WITH PEPSTATIN A  |   TRICHODERMA REESEI, ASPARTIC PROTEINASE, ASPARTYL PROTEASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2p8h:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE COMPLEXED WITH INHIBITOR  |   ASPARTYL PROTEASE, BACE, HYDROLASE 
4i0j:A   (LEU141) to   (GLY217)  SPR AND STRUCTURAL ANALYSIS YIELD INSIGHT TOWARDS MECHANISM OF INHIBITION OF BACE INHIBITORS  |   BACE ASP PROTEASE, HYDROLYSIS,, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4xkx:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 2-AMINOOXAZOLINE 3- AZAXANTHENE INHIBITOR 28  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2q15:A    (LEU80) to   (ALA157)  STRUCTURE OF BACE COMPLEXED TO COMPOUND 3A  |   BACE INHIBITOR COMPLEX, HYDROLASE 
3g70:B    (ASP95) to   (ARG164)  DESIGN AND PREPARATION OF POTENT, NON-PEPTIDIC, BIOAVAILABLE RENIN INHIBITORS  |   HUMAN RENIN, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, ZYMOGEN 
3udp:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 12  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3udr:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE WITH COMPOUND 14  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ufl:A    (LEU80) to   (GLY156)  DISCOVERY OF PYRROLIDINE-BASED B-SECRETASE INHIBITORS: LEAD ADVANCEMENT THROUGH CONFORMATIONAL DESIGN FOR MAINTENANCE OF LIGAND BINDING EFFICIENCY  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2va7:A    (LEU80) to   (ALA157)  X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 27  |   BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE 
2vkm:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE)  |   ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN 
2vkm:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE)  |   ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN 
2vkm:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE)  |   ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN 
2vkm:D    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE)  |   ALTERNATIVE SPLICING, ASPARTYL PROTEASE, ASPARTIC PROTEASE, GLYCOPROTEIN, TRANSMEMBRANE, BETA SECRETASE, APP, BACE, A-BETA, X- RAY, ZYMOGEN, MEMBRANE, PROTEASE, MEMAPSIN, HYDROLASE, ALZHEIMER, DRUG DESIGN 
3hw1:A    (LEU80) to   (ALA157)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN 
3hw1:B    (LEU80) to   (GLY156)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN 
3hw1:C    (LEU80) to   (ALA157)  STRUCTURE OF BACE (BETA SECRETASE) IN COMPLEX WITH LIGAND EV2  |   PROTEASE, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, AMYLOID PRECURSOR PROTEIN SECRETASES, ASPARTIC ENDOPEPTIDASES, FRAGMENT- BASED DRUG DESIGN, FLUORESCENCE POLARISATION, DISULFIDE BOND, TRANSMEMBRANE, ZYMOGEN 
2vnm:A   (ASP144) to   (CYS216)  HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-( PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)BENZAMIDE  |   HYDROLASE, ALTERNATIVE SPLICING, BETA-SITE APP CLEAVING ENZYME, BETA-SECRETASE, ASPARTYL PROTEASE, ASP-2, BACE-1, ZYMOGEN, PROTEASE, MEMBRANE, MEMAPSIN-2, GLYCOPROTEIN, TRANSMEMBRANE 
1sgz:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN.  |   BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE 
1sgz:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN.  |   BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE 
1sgz:C    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN.  |   BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE 
1sgz:D    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN.  |   BETA-SECRETASE, MEMAPSIN, BACE, ASPARTIC PROTEASE, PROTEASE FLAP, DRUG DESIGN, ASP2, ALZHEIMER'S DISEASE, HYDROLASE 
2g1r:B    (ASP90) to   (ARG159)  KETOPIPERAZINE-BASED RENIN INHIBITORS: OPTIMIZATION OF THE C RING  |   PROTEIN-LIGAND COMPLEXES, HYDROLASE 
3i25:A    (LEU80) to   (GLY156)  POTENT BETA-SECRETASE 1 HYDROXYETHYLENE INHIBITOR  |   BACE, BETA-SECRETASE, INHIBITOR, ASPARTYL PROTEASE, PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, TRANSMEMBRANE, ZYMOGEN 
3i25:B    (LEU80) to   (GLY156)  POTENT BETA-SECRETASE 1 HYDROXYETHYLENE INHIBITOR  |   BACE, BETA-SECRETASE, INHIBITOR, ASPARTYL PROTEASE, PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, TRANSMEMBRANE, ZYMOGEN 
3i25:C    (LEU80) to   (GLY156)  POTENT BETA-SECRETASE 1 HYDROXYETHYLENE INHIBITOR  |   BACE, BETA-SECRETASE, INHIBITOR, ASPARTYL PROTEASE, PROTEASE, ALTERNATIVE SPLICING, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, TRANSMEMBRANE, ZYMOGEN 
4l7h:A    (LEU80) to   (ALA157)  DIETHYLAMINOSULFUR TRIFLUORIDE-MEDIATED INTRAMOLECULAR CYCLIZATION OF 2-HYDROXY-BENZYLUREAS TO FUSED BICYCLIC AMINOOXAZOLINE COMPOUNDS AND EVALUATION OF THEIR BIOCHEMICAL ACTIVITY AGAINST BETA-SECRETASE-1 (BACE-1)  |   ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ivi:A   (LEU141) to   (GLY217)  DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS  |   ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3ivi:B   (LEU141) to   (GLY217)  DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS  |   ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3ivi:C   (LEU141) to   (GLY217)  DESIGN AND SYNTHESIS OF POTENT BACE-1 INHIBITORS WITH CELLULAR ACTIVITY: STRUCTURE-ACTIVITY RELATIONSHIP OF P1 SUBSTITUENTS  |   ASPARTYL PROTEASE, BACE-1 INHIBITORS, ALZHEIMER'S DISEASE, STRUCTURE- BASED DRUG DESIGN, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3vv8:A    (LEU80) to   (GLN153)  CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH 2-AMINO-3-METHYL-6- ((1S,2R)-2-(3'-METHYLBIPHENYL-4-YL)CYCLOPROPYL)PYRIMIDIN-4(3H)-ONE  |   ASPARTYL PROTEASE, BASE, BETA-SECRETASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3vye:A    (ASP95) to   (ARG164)  HUMAN RENIN IN COMPLEX WITH INHIBITOR 7  |   ASPARTYL PROTEASE, RAS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3wb5:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF BETA SECETASE IN COMPLEX WITH (6S)-2-AMINO-3,6- DIMETHYL-6-[(1R,2R)-2-PHENYLCYCLOPROPYL]-3,4,5,6-TETRAHYDROPYRIMIDIN- 4-ONE  |   PROTEASE 2, ASP2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN- 2, HYDROLASE 
2iqg:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HYDROXYETHYL SECONDARY AMINE-BASED PEPTIDOMIMETIC INHIBITOR OF HUMAN BETA-SECRETASE (BACE)  |   PROTEIN-INHIBITOR COMPLEX, HYDROLASE 
1w51:A    (ASP83) to   (CYS155)  BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON- PEPTIDIC INHIBITOR  |   HYDROLASE/INHIBITOR, HYDROLASE/INHIBITOR COMPLEX, ALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN 
3zlq:A    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX 
3zlq:B    (VAL96) to   (GLY172)  BACE2 XAPERONE COMPLEX  |   HYDROLASE-IMMUNE SYSTEM COMPLEX 
3zov:A   (LEU141) to   (CYS216)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND  |   HYDROLASE 
3k1w:B    (ASP95) to   (ASN163)  NEW CLASSES OF POTENT AND BIOAVAILABLE HUMAN RENIN INHIBITORS  |   RENIN, PROTEASE, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, SECRETED, ZYMOGEN 
3k5g:A    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH BJC060  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5g:B    (LEU80) to   (GLY156)  HUMAN BACE-1 COMPLEX WITH BJC060  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
3k5g:C    (LEU80) to   (ALA157)  HUMAN BACE-1 COMPLEX WITH BJC060  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, STRUCTURE-BASED DESIGN, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, MEMBRANE, PROTEASE, TRANSMEMBRANE 
1m4h:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3  |   MEMAPSIN2, BASE, ASP2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
1m4h:B    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3  |   MEMAPSIN2, BASE, ASP2, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
2zji:A    (LEU80) to   (CYS155)  CRYSTAL STRUCTURE OF THE HUMAN BACE1 CATALYTIC DOMAIN IN COMPLEX WITH N-[1-(2,6-DIMETHOXY-BENZYL)-PIPERIDIN-4-YL]-4-MERCAPTO-BUTYRAMIDE  |   BACE1, SMALL-MOLECULE INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
4acu:A    (ASP83) to   (GLY156)  AMINOIMIDAZOLES AS BACE-1 INHIBITORS. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14  |   HYDROLASE, ALZHEIMER'S DISEASE 
4acx:A    (LEU80) to   (GLY156)  AMINOIMIDAZOLES AS BACE-1 INHIBITORS. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 23  |   HYDROLASE, ALZHEIMER'S DISEASE 
3l3a:A   (LEU142) to   (ALA219)  BACE-1 WITH THE AMINOPYRIDINE COMPOUND 32  |   BETA-SECRETASE, BACE-1, INHIBITOR, AMINOPYRIDINE, ASPARTYL PROTEASE, DISULFIDE BOND, PROTEASE, TRANSMEMBRANE, HYDROLASE 
3l59:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH710413  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l59:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH710413  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5f:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH736201  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3l5f:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH736201  |   BACE1, ALZHEIMERS, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENDOSOME, GLYCOPROTEIN, GOLGI APPARATUS, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
4amt:A   (ASP138) to   (TYR205)  CRYSTAL STRUCTURE AT 2.6A OF HUMAN PRORENIN  |   HYDROLASE, HORMONE, 
3lpi:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH745132  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE 
3lpi:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH745132  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE 
4auc:A    (ASP89) to   (ASP158)  BOVINE CHYMOSIN IN COMPLEX WITH PEPSTATIN A  |   HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE INHIBITOR, PEPTIDASE, INHIBITION 
4b78:A    (LEU80) to   (ALA157)  AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB-LOWERING IN BRAIN  |   HYDROLASE, HYDROLASE INHIBITOR, LEAD GENERATION, STRUCTURE-BASED DRUG DESIGN 
3n4l:B    (LEU86) to   (CYS161)  BACE-1 IN COMPLEX WITH ELN380842  |   BACE, HYDROXYETHYLAMINE, BETA SECRETASE, ALZHEIMER'S DISEASE, AD, BETA-AMYLOID PRECURSOR PROTEIN, BETA-APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3n4l:C    (GLY87) to   (CYS161)  BACE-1 IN COMPLEX WITH ELN380842  |   BACE, HYDROXYETHYLAMINE, BETA SECRETASE, ALZHEIMER'S DISEASE, AD, BETA-AMYLOID PRECURSOR PROTEIN, BETA-APP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4rcd:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH A 2-AMINOOXAZOLINE 4- AZAXANTHENE INHIBITOR  |   ASPARTYL PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, BRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3cic:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH709583  |   BACE1, ASPARTYL PROTEASE, HYDROLASE 
3cic:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO SCH709583  |   BACE1, ASPARTYL PROTEASE, HYDROLASE 
3ckp:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR  |   BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3ckp:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH INHIBITOR  |   BETA-SECRETASE, ASPARTYL PROTEASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, TRANSMEMBRANE, ZYMOGEN 
3nsh:A    (LEU86) to   (GLY162)  BACE-1 IN COMPLEX WITH ELN475957  |   MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE 
3nsh:B    (LEU86) to   (ALA163)  BACE-1 IN COMPLEX WITH ELN475957  |   MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE 
3nsh:C    (LEU86) to   (GLY162)  BACE-1 IN COMPLEX WITH ELN475957  |   MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, HYDROLASE 
4rrs:A   (LEU141) to   (GLY217)  8-TETRAHYDROPYRAN-2-YL CHROMANS: HIGHLY SELECTIVE BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) INHIBITORS  |   ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4try:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE1 COMPLEX WITH A HEA-TYPE INHIBITOR  |   HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4try:B   (LEU141) to   (GLY217)  STRUCTURE OF BACE1 COMPLEX WITH A HEA-TYPE INHIBITOR  |   HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4try:C   (LEU141) to   (GLY217)  STRUCTURE OF BACE1 COMPLEX WITH A HEA-TYPE INHIBITOR  |   HYDRASE PROTEINASE CONVERTING, DESIGNED INHIBITOR, HYDRASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ohf:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-655295 AKA N~3~-((1S,2R)-1- BENZYL-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~, N~1~-DIBUTYL-1H-INDOLE-1,3- DICARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3ohf:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-655295 AKA N~3~-((1S,2R)-1- BENZYL-2-HYDROXY-3-((3- METHOXYBENZYL)AMINO)PROPYL)-N~1~, N~1~-DIBUTYL-1H-INDOLE-1,3- DICARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2,ASPARTIC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3dm6:A    (LEU80) to   (ALA157)  BETA-SECRETASE 1 COMPLEXED WITH STATINE-BASED INHIBITOR  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3dm6:B    (LEU80) to   (ALA157)  BETA-SECRETASE 1 COMPLEXED WITH STATINE-BASED INHIBITOR  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
3dm6:C    (LEU80) to   (ALA157)  BETA-SECRETASE 1 COMPLEXED WITH STATINE-BASED INHIBITOR  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ALTERNATIVE SPLICING, ASPARTYL PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN 
4d83:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d83:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4d83:C    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF HUMAN BETA SECRETASE IN COMPLEX WITH NVP-BUR436, DERIVED FROM A CO-CRYSTALLIZATION EXPERIMENT  |   BETA-SECRETASE, MEMAPSIN2, BACE1, ASPARTIC PROTEINASE, ALZHEIMER'S DISEASE, ENZYME INHIBITOR COMPLEX, STRUCTURE-BASED DRUG DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djx:A   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 5-(3-(5-CHLOROPYRIDIN-3-YL)PHENYL)-5- CYCLOPROPYL-2-IMINO-3-METHYLIMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4djx:B   (LEU141) to   (ALA218)  STRUCTURE OF BACE BOUND TO 5-(3-(5-CHLOROPYRIDIN-3-YL)PHENYL)-5- CYCLOPROPYL-2-IMINO-3-METHYLIMIDAZOLIDIN-4-ONE  |   BACE1, ALZHEIMERS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5htz:A   (LEU141) to   (ALA218)  BACE1 IN COMPLEX WITH (S)-5-(3-CHLORO-5-(5-(PROP-1-YN-1-YL)PYRIDIN-3- YL)THIOPHEN-2-YL)-2,5-DIMETHYL-1,2,4-THIADIAZINAN-3-IMINIUM 1,1- DIOXIDE  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5htz:B   (LEU141) to   (ALA218)  BACE1 IN COMPLEX WITH (S)-5-(3-CHLORO-5-(5-(PROP-1-YN-1-YL)PYRIDIN-3- YL)THIOPHEN-2-YL)-2,5-DIMETHYL-1,2,4-THIADIAZINAN-3-IMINIUM 1,1- DIOXIDE  |   ALZHEIMER'S, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5ie1:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH 3-(2-AMINO-6-(O-TOLYL) QUINOLIN-3-YL)-N-(3,3-DIMETHYLBUTYL)PROPANAMIDE  |   ASPARTIC PROTEASE, ALZHEIMER'S DISEASE, APP, AMYLOID PRECURSOR PROTEIN, HYDROLASE 
4exg:A   (LEU128) to   (CYS203)  DESIGN AND SYNTHESIS OF POTENT HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS  |   BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX 
3r2f:A    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3r2f:B    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3r2f:D    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
3r2f:E    (LEU80) to   (GLY156)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH BMS-693391 AKA (2S)-2-((3R)-3-ACETAMIDO-3-ISOBUTYL-2-OXO-1- PYRROLIDINYL)-N-((1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-((2R,4R)- 4-PROPOXY-2-PYRROLIDINYL)ETHYL)-4-PHENYLBUTANAMIDE  |   ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, BETA-SECRETASE, MEMAPSIN 2, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4fri:A    (LEU80) to   (ALA157)  CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH BIARYLSPIRO AMINOOXAZOLINE 6  |   MEMBRANE PROTEIN, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, HYDROLASE- INHIBITOR COMPLEX 
4fse:A   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4fse:B   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4fse:D   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4fse:E   (LEU128) to   (ALA205)  CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 (BACE-WT) COMPLEX WITH N-(N-(4-AMINO-3,5- DICHLOROBENZYL)CARBAMIMIDOYL)-3-(4- METHOXYPHENYL)-5- METHYL-4-ISOTHIAZOLECARBOXAMIDE  |   ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR COMPLEX 
4gj6:A    (ASP87) to   (ARG157)  CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AYZ832 (COMPOUND 6A)  |   RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
4gj6:B    (ASP87) to   (ASN156)  CRYSTAL STRUCTURE OF RENIN IN COMPLEX WITH NVP-AYZ832 (COMPOUND 6A)  |   RENIN INHIBITOR, PHARMACOPHORE SEARCH, TRANS-3,4-DISUBSTITUTED PYRROLIDINE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5kqf:A   (LEU128) to   (GLY204)  (4~{S},6~{S})-4-[2,4-BIS(FLUORANYL)PHENYL]-4-METHYL-6-PYRIMIDIN-5-YL- 5,6-DIHYDRO-1,3-THIAZIN-2-AMINE (COMPOUND 12) BOUND TO BACE1  |   BACE-1, SMALL MOLECULE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX 
5kr8:A   (LEU128) to   (CYS203)  (4~{S},6~{S})-4-[2,4-BIS(FLUORANYL)PHENYL]-6-(3,5-DIMETHYL-1,2-OXAZOL- 4-YL)-4-METHYL-5,6-DIHYDRO-1,3-THIAZIN-2-AMINE (COMPOUND 5) BOUND TO BACE1  |   BACE-1, SMALL MOLECULE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX