2obc:A (THR266) to (VAL365) THE CRYSTAL STRUCTURE OF RIBD FROM ESCHERICHIA COLI IN COMPLEX WITH A SUBSTRATE ANALOGUE, RIBOSE 5-PHOSPHATE (BETA FORM), BOUND TO THE ACTIVE SITE OF THE REDUCTASE DOMAIN | ALPHA AND BETA CLASS OF PROTEINS WITH MAINLY PARALLELL STRANDS, SUBSTRATE ANALOGUE COMPLEX (RIBOSE 5-PHOSPHATE, BETA-FORM), STRUCTURAL GENOMICS, HTP ESCHERICHIA COLI PROTEINS, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, HYDROLASE, OXIDOREDUCTASE
2anq:A (VAL72) to (ARG158) CRYSTAL STRUCTURE OF E.COLI DHFR IN COMPLEX WITH NADPH AND THE INHIBITOR COMPOUND 10A. | DHFR, PROTEIN INHIBITOR COMPLEX, OXIDOREDUCTASE
1ao8:A (ALA73) to (LYS160) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES | OXIDOREDUCTASE, INHIBITOR/ENZYME COMPLEX
2b3z:A (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN AND REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
2b3z:B (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN AND REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
2b3z:C (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN AND REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
2b3z:D (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN AND REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4ha9:A (ASP146) to (ALA239) STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7 | REDUCTASE, NADPH BINDING, OXIDOREDUCTASE
4ha9:B (ASP146) to (ASP243) STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7 | REDUCTASE, NADPH BINDING, OXIDOREDUCTASE
3s1a:C (LEU343) to (VAL455) CRYSTAL STRUCTURE OF THE PHOSPHORYLATION-SITE DOUBLE MUTANT S431E/T432E OF THE KAIC CIRCADIAN CLOCK PROTEIN | HEXAMER, ATP BINDING, AUTO-KINASE, PHOPHATASE, SERINE THREONINE KINASE, MG BINDING, PHOSPHORYLATION, TRANSFERASE
3ex8:A (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE
3ex8:B (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE
3ex8:C (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE
3ex8:D (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE
3f0b:X (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-PHENYLPHENYL)BUT-1-YNYL]-6- METHYLPYRIMIDINE | OXIDOREDUCTASE
3f0q:X (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(2,6-DIMETHYLPHENYL)PHENYL)BUT-1-YNYL]- 6-METHYLPYRIMIDINE | OXIDOREDUCTASE
3f0s:X (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL)PHENYL)BUT-1-YNYL]- 6-METHYLPYRIMIDINE | OXIDOREDUCTASE
3f0u:X (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-PHENYLPHENYL)BUT-1- YNYL]-6-METHYLPYRIMIDINE | OXIDOREDUCTASE
2bla:A (VAL149) to (SER236) SP21 DOUBLE MUTANT P. VIVAX DIHYDROFOLATE REDUCTASE IN COMPLEX WITH PYRIMETHAMINE | DIHYDROFOLATE REDUCTASE, PLASMODIUM VIVAX, PYRIMETHAMINE, MALARIA, DRUG RESISTANCE, OXIDOREDUCTASE
2bl9:A (LYS148) to (LYS237) X-RAY CRYSTAL STRUCTURE OF PLASMODIUM VIVAX DIHYDROFOLATE REDUCTASE IN COMPLEX WITH PYRIMETHAMINE AND ITS DERIVATIVE | DIHYDROFOLATE REDUCTASE, PLAMODIUM VIVAX, PYRIMETHAMINE, MALARIA, DRUG RESISTANCE, OXIDOREDUCTASE
3s9u:A (GLU75) to (GLN162) BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP120J | OXIDOREDUCTASE
3sa1:B (GLU75) to (GLN162) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1021 | OXIDOREDUCTASE
3sa2:A (GLU75) to (GLN162) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1014 | OXIDOREDUCTASE
3sa2:B (GLU75) to (GLN162) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1014 | OXIDOREDUCTASE
3sai:A (GLU75) to (GLN162) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP1015 | OXIDOREDUCTASE
3sai:B (GLU75) to (GLN162) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP1015 | OXIDOREDUCTASE
1bzf:A (VAL74) to (ALA162) NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES | OXIDOREDUCTASE, INHIBITOR/ENZYME COMPLEX
4xe6:X (ASP74) to (LYS157) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1061) | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4xec:X (ASP74) to (LYS157) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1061) | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4i1n:A (VAL72) to (ARG159) R104A-CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX | ALPHA/BETA FOLD, IMMUNOGLOBULIN FOLD, REDUCTASE, NADPH, FOLATE DERIVATIVES, HYDRIDE TRANSFER, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
3fl8:A (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:B (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:C (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:D (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:E (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:F (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:G (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:H (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:A (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:B (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:C (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:D (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:E (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:F (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:G (GLU75) to (LYS160) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fq0:A (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
3fqc:B (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]-6- METHYLPYRIMIDINE (UCP115A) | OXIDOREDUCTASE
3fqf:A (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]- 6-METHYLPYRIMIDINE (UCP115A) | OXIDOREDUCTASE
3frb:X (VAL73) to (ARG156) S. AUREUS F98Y DHFR COMPLEXED WITH TMP | S. AUREUS DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3frd:X (ASP74) to (ARG156) S. AUREUS DHFR COMPLEXED WITH NADPH AND FOLATE | S AUREUS DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3fre:X (ASP74) to (ARG156) S. AUREUS DHFR COMPLEXED WITH NADPH AND TMP | DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3sqy:X (ASP75) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3sr5:X (VAL74) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srq:X (ASP75) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srr:X (ASP75) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srs:X (ASP75) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3sru:X (ASP75) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srw:X (ASP75) to (ARG157) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3fy8:X (VAL73) to (ARG156) CRYSTAL STRUCTURE OF STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR- 101 | DHFR, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
3fyw:X (VAL73) to (ARG156) STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR-101 | STAPH. AUREUS DHFR, AR-101, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
1cz3:A (SER74) to (VAL163) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1cz3:B (SER74) to (VAL163) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1dhj:A (VAL72) to (ARG159) LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
1dis:A (ALA73) to (LYS160) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE | INHIBITOR/ENZYME COMPLEX, OXIDO-REDUCTASE
4xt4:A (ALA160) to (LYS257) CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTEIRUM TUBERCULOSIS IN COMPLEX WITH DIHYDROPTERIDINE RING OF DIHYDROPTEROIC ACID | REDUCTASE, PTERIDINE, STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, OXIDOREDUCTASE
4xt5:A (GLU161) to (LYS257) CRYSTAL STRUCTURE OF RV2671 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH NADP+ | REDUCTASE, COFACTOR, STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, OXIDOREDUCTASE
1dre:A (VAL72) to (ARG159) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1drh:A (VAL72) to (ARG158) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyh:A (VAL72) to (ARG158) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyj:A (VAL72) to (ARG159) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
2d5n:A (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE
2d5n:B (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE
2d5n:C (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE
2d5n:D (ASN261) to (LYS357) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE
2drc:A (VAL72) to (ARG159) INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS | OXIDOREDUCTASE
3tq8:A (ASP75) to (ASN163) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH TRIMETHOPRIM | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3tq9:A (ASP75) to (ARG160) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH METHOTREXATE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3tqb:A (ASP75) to (ARG160) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH FOLATE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3tqa:A (ASP75) to (ARG160) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH NADPH | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
1rf7:A (VAL72) to (ARG158) STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rh3:A (VAL72) to (ARG159) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx1:A (VAL72) to (ARG158) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx5:A (VAL72) to (ARG158) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE | OXIDO-REDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1rx6:A (VAL72) to (ARG159) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDO-REDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1rx9:A (VAL72) to (ARG158) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
4kjj:A (VAL72) to (ARG158) CRYOGENIC WT DHFR | ROSSMANN FOLD, OXIDOREDUCTASE
4kjl:A (VAL73) to (ARG159) ROOM TEMPERATURE N23PPS148A DHFR | ROSSMANN FOLD, OXIDOREDUCTASE
2g6v:A (THR266) to (VAL365) THE CRYSTAL STRUCTURE OF RIBD FROM ESCHERICHIA COLI | RIBD APO STRUCTURE, STRUCTURAL GENOMICS, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, HYDROLASE, OXIDOREDUCTASE
3ia5:B (VAL74) to (LYS162) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) | DHFR DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
2w3v:A (ALA80) to (ARG166) MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
4lae:X (ASP75) to (ARG157) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | DHFR, PROTEIN-INHIBITOR COMPLEX, FOLATE, NADPH, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4lag:X (ASP75) to (ARG157) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | PROTEIN-INHIBITOR COMPLEX, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4lah:X (ASP75) to (ARG157) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | DHFR, PROTEIN-INHIBITOR COMPLEX, FOLATE, NADPH, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4lek:X (ASP75) to (ARG157) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
2w9s:C (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9s:E (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
3ix9:A (ALA78) to (ARG165) CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT | CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE
2hm9:A (VAL74) to (ALA162) SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM, 33 STRUCTURES | OXIDOREDUCTASE, DHFR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
2hxv:A (VAL254) to (PRO344) CRYSTAL STRUCTURE OF A DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE/ 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (TM1828) FROM THERMOTOGA MARITIMA AT 1.80 A RESOLUTION | OXIDOREDUCTASE, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, BIOSYNTHETIC PROTEIN
1j3i:B (TYR141) to (LYS228) WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH WR99210, NADPH, AND DUMP | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
1vdr:B (THR75) to (ARG157) DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, HALOPHILIC ENZYME
2xw7:A (GLN87) to (LYS169) STRUCTURE OF MYCOBACTERIUM SMEGMATIS PUTATIVE REDUCTASE MS0308 | OXIDOREDUCTASE, NADPH
2xw7:B (GLN87) to (LYS169) STRUCTURE OF MYCOBACTERIUM SMEGMATIS PUTATIVE REDUCTASE MS0308 | OXIDOREDUCTASE, NADPH
3zpc:A (GLY262) to (GLN358) ACINETOBACTER BAUMANNII RIBD, FORM 1 | OXIDOREDUCTASE, REDUCTASE, DEAMINASE
3zpc:B (VAL263) to (GLN358) ACINETOBACTER BAUMANNII RIBD, FORM 1 | OXIDOREDUCTASE, REDUCTASE, DEAMINASE
2l28:A (ALA73) to (ALA162) SOLUTION STRUCTURE OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE APO- FORM, 25 CONFORMERS | OXIDOREDUCTASE, DHFR, ANTIFOLATES, CO-OPERATIVE BINDING
2lf1:A (VAL74) to (LYS160) SOLUTION STRUCTURE OF L. CASEI DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH, 30 STRUCTURES | OXIDOREDUCTASE, DHFR, POSITIVE COOPERATIVITY, PROTEIN-LIGAND INTERACTIONS
4nx7:A (VAL72) to (ARG158) SINGLE CRYOGENIC TEMPERATURE MODEL OF DHFR | FOLATE METABOLISM, OXIDOREDUCTASE
5cc9:A (VAL72) to (ARG158) L28F E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE | FOLATE METABOLISM, OXIDOREDUCTASE
5ccc:A (VAL72) to (ARG159) WILD-TYPE E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE | FOLATE METABOLISM, OXIDOREDUCTASE
3jsu:B (VAL140) to (LYS228) QUADRUPLE MUTANT(N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE(PFDHFR-TS) COMPLEXED WITH QN254, NADPH, AND DUMP | ROSSMANN FOLD, OXIDOREDUCTASE, TRANSFERASE
3jtw:B (ILE90) to (GLN175) CRYSTAL STRUCTURE OF PUTATIVE DIHYDROFOLATE REDUCTASE (YP_805003.1) FROM PEDIOCOCCUS PENTOSACEUS ATCC 25745 AT 1.90 A RESOLUTION | YP_805003.1, PUTATIVE DIHYDROFOLATE REDUCTASE, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, RIBD C-TERMINAL DOMAIN, OXIDOREDUCTASE
3jw3:A (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (F96I) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jw3:B (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (F96I) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwc:A (GLU75) to (ASP146) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwc:B (GLU75) to (ASP146) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwf:A (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (R)-2,4-DIAMINO-5-(3-HYDROXY-3-(3, 4,5-TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP113A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwf:B (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (R)-2,4-DIAMINO-5-(3-HYDROXY-3-(3, 4,5-TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP113A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwm:A (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (S)-2,4-DIAMINO-5-(3-METHOXY-3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP114A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwm:B (GLU75) to (ASP146) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (S)-2,4-DIAMINO-5-(3-METHOXY-3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP114A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3k0a:E (LEU343) to (VAL455) CRYSTAL STRUCTURE OF THE PHOSPHORYLATION-SITE MUTANT S431A OF THE KAIC CIRCADIAN CLOCK PROTEIN | KAIC, CIRCADIAN CLOCK PROTEIN, KINASE, HEXAMER, ATP-BINDING, BIOLOGICAL RHYTHMS, DNA-BINDING, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, REPRESSOR, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE
3k0c:A (LEU343) to (VAL455) CRYSTAL STRUCTURE OF THE PHOSPHORYLATION-SITE DOUBLE MUTANT S431A/T432E OF THE KAIC CIRCADIAN CLOCK PROTEIN | KAIC, CIRCADIAN CLOCK PROTEIN, KINASE, HEXAMER, ATP-BINDING, BIOLOGICAL RHYTHMS, DNA-BINDING, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, REPRESSOR, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE
3k45:A (PHE88) to (LYS185) ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF 2,4- DIAMINOFURO[2,3D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND MOUSE DIHYDROFOLATE REDUCTASE | PROTEIN LIGAND COFACTOR TERNARY COMPLEX, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1lud:A (ALA73) to (ALA162) SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES | DHFR, INHIBITOR/ENZYME COMPLEX, OXIDOREDUCTASE
2o7p:A (THR266) to (VAL365) THE CRYSTAL STRUCTURE OF RIBD FROM ESCHERICHIA COLI IN COMPLEX WITH THE OXIDISED NADP+ COFACTOR IN THE ACTIVE SITE OF THE REDUCTASE DOMAIN | NADP+ COMPLEX, ALPHA AND BETA CLASS WITH MAINLY PARALLELL BETA STRANDS, STRUCTURAL GENOMICS, HTP-PROTEIN ESCHERICHIA COLI, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, HYDROLASE, OXIDOREDUCTASE
4or7:A (VAL72) to (HIS162) KLEBSIELLA PNEUMONIAE DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-{3-[3-(PYRIMIDIN-5-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4- DIAMINE | 5,6,7,8-TETRAHYDROFOLATE; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:A (VAL72) to (ARG158) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:B (VAL72) to (ARG158) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:C (VAL72) to (ARG159) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:D (VAL72) to (ARG158) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3kfy:A (VAL72) to (ARG158) DYNAMIC SWITCHING AND PARTIAL OCCUPANCIES OF A SMALL MOLECULE INHIBITOR COMPLEX OF DHFR | SMALL MOLECULE INHIBITOR, DYNAMICS, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE
3kgy:A (GLY120) to (ARG211) CRYSTAL STRUCTURE OF PUTATIVE DIHYDROFOLATE REDUCTASE (YP_001636057.1) FROM CHLOROFLEXUS AURANTIACUS J-10-FL AT 1.50 A RESOLUTION | PUTATIVE DIHYDROFOLATE REDUCTASE, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, OXIDOREDUCTASE
3kgy:B (GLY120) to (ARG211) CRYSTAL STRUCTURE OF PUTATIVE DIHYDROFOLATE REDUCTASE (YP_001636057.1) FROM CHLOROFLEXUS AURANTIACUS J-10-FL AT 1.50 A RESOLUTION | PUTATIVE DIHYDROFOLATE REDUCTASE, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, OXIDOREDUCTASE
4p66:A (VAL72) to (ARG159) ELECTROSTATICS OF ACTIVE SITE MICROENVIRONMENTS OF E. COLI DHFR | OXIDOREDUCTASE, CATALYSIS, ELECTROSTATICS, CATALYTIC CYCLE
3ky8:A (PHE90) to (ARG175) CRYSTAL STRUCTURE OF PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN (YP_001092907.1) FROM SHEWANELLA SP. PV-4 AT 2.12 A RESOLUTION | PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, BIOSYNTHETIC PROTEIN
3ky8:B (PHE90) to (ARG175) CRYSTAL STRUCTURE OF PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN (YP_001092907.1) FROM SHEWANELLA SP. PV-4 AT 2.12 A RESOLUTION | PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, BIOSYNTHETIC PROTEIN
5dfr:A (VAL72) to (ARG158) CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING | OXIDO-REDUCTASE, OXIDOREDUCTASE
4pst:A (VAL72) to (ARG158) MULTICONFORMER MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 277 K | REDUCTASE, OXIDOREDUCTASE
4psy:A (VAL72) to (ARG158) 100K CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE | REDUCTASE, OXIDOREDUCTASE
4ptj:A (VAL72) to (ARG158) ENSEMBLE MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 277K | ROSSMANN FOLD, OXIDOREDUCTASE
4q67:A (VAL73) to (ARG156) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH | OXIDOREDUCTASE
4q6a:A (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS V31L, F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH | OXIDOREDUCTASE
5e8q:A (VAL72) to (ARG158) CRYSTAL STRUCTURE OF DHFR IN 20% ISOPROPANOL | DYNAMICS, OXIDOREDUCTASE
3m09:A (ASP74) to (ARG156) F98Y TMP-RESISTANT DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS WITH INHIBITOR RAB1 | FOLATE, DHFR, ANTIMICROBIAL, ANTIBIOTIC RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qi9:A (VAL73) to (ARG159) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qi9:B (VAL73) to (GLY161) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qi9:C (THR74) to (ARG159) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qlf:A (VAL72) to (ARG158) CRYSTAL STRUCTURE OF I14G DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+ | DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE
3n0h:A (HIS87) to (ASN185) HDHFR DOUBLE MUTANT Q35S/N64F TRIMETHOPRIM BINARY COMPLEX | DOUBLE MUTANT HUMAN DIHYDROFOLATE REDUCTASE TRIMETHOPRIM, OXIDOREDUCTASE
5fda:A (THR74) to (ARG159) THE HIGH RESOLUTION STRUCTURE OF APO FORM DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS AT 1.55 A | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, DIHYDROFOLATE REDUCTASE, YERSINIA PESTIS, OXIDOREDUCTASE
3och:A (VAL72) to (ARG159) CHEMICALLY SELF-ASSEMBLED ANTIBODY NANORINGS (CSANS): DESIGN AND CHARACTERIZATION OF AN ANTI-CD3 IGM BIOMIMETIC | OXIDOREDUCTASE
3dga:B (ASP139) to (LYS228) WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF01302, NADPH, AND DUMP | ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE
4tu5:X (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1062) | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4dfr:A (VAL72) to (ARG159) CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE | OXIDO-REDUCTASE
5hi6:A (VAL73) to (ARG159) THE HIGH RESOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEX WITH METHOTREXATE AS CLOSED FORM | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, DIHYDROFOLATE REDUCTASE, YERSINIA PESTIS, OXIDOREDUCTASE
3e0b:A (GLU75) to (GLN162) BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2, 4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
3e0b:B (GLU75) to (GLN162) BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2, 4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
4eck:B (GLN121) to (LYS250) CRYSTAL STRUCTURE OF THE TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, TRANSFERASE, OXIDOREDUCTASE
4eig:A (ARG71) to (ARG158) CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR | NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4eiz:A (VAL72) to (ARG158) STRUCTURE OF NB113 BOUND TO APODHFR | NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4eiz:B (VAL72) to (ARG158) STRUCTURE OF NB113 BOUND TO APODHFR | NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4ele:A (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:B (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:C (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:D (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:E (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:F (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:G (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:H (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:A (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:H (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:C (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:B (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:G (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:F (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:D (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:E (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3q3i:A (ASP313) to (PRO404) CRYSTAL STRUCTURE OF THE ACTINOBACILLUS PLEUROPNEUMONIAE HMW1C GLYCOSYLTRANSFERASE IN THE PRESENCE OF PEPTIDE N1131 | HMW1C, HMW1, N-GLYCOSYLATION, TRANSFERASE
3qyl:A (VAL72) to (ARG158) SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE
3qyo:A (VAL72) to (ARG158) SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE
4g3m:A (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG: THE DEAMINATION PROCESS IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4g3m:B (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG: THE DEAMINATION PROCESS IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4g3m:C (ASN261) to (LYS357) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG: THE DEAMINATION PROCESS IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4g3m:D (ASN261) to (PRO358) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG: THE DEAMINATION PROCESS IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4gh8:B (VAL76) to (ARG162) CRYSTAL STRUCTURE OF A 'HUMANIZED' E. COLI DIHYDROFOLATE REDUCTASE | TETRAHYDROFOLATE, ENZYME CATALYSIS, EVOLUTION, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
5t0l:B (ARG123) to (LYS250) CRYSTAL STRUCTURE OF TOXOPLASMA GONDII TS-DHFR COMPLEXED WITH NADPH, DUMP, PDDF AND 5-(4-(3,4-DICHLOROPHENYL)PIPERAZIN-1-YL)PYRIMIDINE-2, 4-DIAMINE (TRC-15) | TOXOPLASMA GONDII, DHFR, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
6dfr:A (VAL72) to (ARG158) CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE | OXIDO-REDUCTASE
7dfr:A (VAL72) to (ARG158) CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE | OXIDO-REDUCTASE
8dfr:A (TYR88) to (SER185) REFINED CRYSTAL STRUCTURES OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE. 3 ANGSTROMS APO-ENZYME AND 1.7 ANGSTROMS NADPH HOLO-ENZYME COMPLEX | OXIDOREDUCTASE(CHNH(D)-NAD+ OR NADP+(A))
2ano:A (VAL72) to (ARG159) CRYSTAL STRUCTURE OF E.COLI DIHYDROFOLATE REDUCTASE IN COMPLEX WITH NADPH AND THE INHIBITOR MS-SH08-17 | DHFR, PROTEIN INHIBITOR COMPLEX, OXIDOREDUCTASE
4ha7:A (ASP146) to (ALA239) STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7 | REDUCTASE, NADPH BINDING, OXIDOREDUCTASE
4ha7:B (ASP146) to (ASP243) STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7 | REDUCTASE, NADPH BINDING, OXIDOREDUCTASE
3f0v:X (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(2,6-DIMETHYLPHENYL) PHENYL)BUT-1-YNYL]-6-METHYLPYRIMIDINE | OXIDOREDUCTASE
4i13:A (VAL72) to (ARG158) NANOBODY CA1697 BINDING TO THE DHFR.FOLATE BINARY COMPLEX | ALPHA/BETA FOLD, IMMUNOGLOBULIN FOLD, REDUCTASE, NADPH, FOLATE DERIVATIVES, REDUCTION, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
3fqo:A (ASP74) to (ARG156) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL]-6- ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
1d1g:A (SER74) to (SER162) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1d1g:B (SER74) to (GLU164) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1ddr:A (VAL72) to (ARG158) MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA | OXIDO-REDUCTASE
1dds:A (VAL72) to (GLU157) MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE | OXIDO-REDUCTASE
2qk8:A (GLU75) to (GLN162) CRYSTAL STRUCTURE OF THE ANTHRAX DRUG TARGET, BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE, METHOTREXATE, PTERIDINE BINDING, NUCLEOTIDE PHOSPHATE BINDING, PSEUDO-ROSSMAN FOLD
1rc4:A (VAL72) to (ARG158) DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx4:A (VAL72) to (ARG158) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND 2'-MONOPHOSPHOADENOSINE 5'- DIPHOSPHORIBOSE | OXIDO-REDUCTASE NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1rx7:A (VAL72) to (ARG158) STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
2w9g:A (ASP74) to (LYS157) WILD-TYPE STAPHYLOCOCCUS AUREUS DHFR IN COMPLEX WITH NADPH AND TRIMETHOPRIM | OXIDOREDUCTASE, ONE-CARBON METABOLISM
2w9h:A (ASP74) to (ARG156) WILD-TYPE STAPHYLOCOCCUS AUREUS DHFR IN COMPLEX WITH TRIMETHOPRIM | OXIDOREDUCTASE, ONE-CARBON METABOLISM
2hqp:A (VAL74) to (LYS160) SOLUTION STRUCTURE OF L.CASEI DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH, 32 STRUCTURES | OXIDOREDUCTASE, DHFR
1jom:A (VAL72) to (GLU129) THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE | METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM OXIDOREDUCTASE
3jvx:A (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5-TRIMETHOXYPHENYL) PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jvx:B (GLU75) to (GLN162) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5-TRIMETHOXYPHENYL) PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3k74:A (VAL72) to (ARG158) DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY | IMMUNOGLOBULIN, PROTEIN-NANOBODY COMPLEX, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE
4pss:A (VAL72) to (ARG158) MULTICONFORMER MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 100K | REDUCTASE, OXIDOREDUCTASE
3m08:A (ASP74) to (ARG156) WILD TYPE DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS WITH INHIBITOR RAB1 | FOLATE, DHFR, ANTIMICROBIAL, ANTIBIOTIC RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE', OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5ecc:A (ASN72) to (GLY156) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(2- METHOXY-5-(PYRIDIN-4-YL)PHENYL)PROP-1-YN-1-YL)PYRIMIDINE-2,4-DIAMINE | OXIDOREDUCTASE, ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5ecc:B (ASN72) to (GLY156) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(2- METHOXY-5-(PYRIDIN-4-YL)PHENYL)PROP-1-YN-1-YL)PYRIMIDINE-2,4-DIAMINE | OXIDOREDUCTASE, ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5ecx:A (ASN72) to (GLY156) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(6- (PYRIDIN-4-YL)BENZO[D][1,3]DIOXOL-4-YL)BUT-1-YN-1-YL)PYRIMIDINE-2,4- DIAMINE | ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
5ecx:B (ASN72) to (LYS155) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(6- (PYRIDIN-4-YL)BENZO[D][1,3]DIOXOL-4-YL)BUT-1-YN-1-YL)PYRIMIDINE-2,4- DIAMINE | ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4dph:B (VAL140) to (LYS228) QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P65 AND NADPH | PLASMODIUM FALCIPARUM, ANTIFOLATE, ROSSMANN FOLD, REDUCTASE, NADPH BINDING, OXIDOREDUCTASE, TRANSFERASE
4elf:A (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:B (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:C (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:D (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:E (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:F (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:G (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:H (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:A (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:H (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:C (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:B (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:G (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:F (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:D (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:E (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:A (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:B (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:C (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:D (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:E (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:F (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:G (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:H (GLU75) to (LYS160) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3q1h:A (THR74) to (ARG159) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, CYTOSOL, OXIDOREDUCTASE
4fgg:A (ASP74) to (ARG156) S. AUREUS DIHYDROFOLATE REDUCTASE CO-CRYSTALLIZED WITH PROPYL-DAP ISOBUTENYL-DIHYDROPHTHALAZINE INHIBITOR | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-INHIBITOR COMPLEX
4fgh:A (ASP74) to (ARG156) S. AUREUS DIHYDROFOLATE REDUCTASE CO-CRYSTALLIZED WITH ETHYL-DAP ISOBUTENYL-DIHYDROPHTHALAZINE INHIBITOR | OXIDOREDUCTASE-INHIBITOR COMPLEX
3r33:A (VAL72) to (ARG158) EVIDENCE FOR DYNAMIC MOTION IN PROTEINS AS A MECHANISM FOR LIGAND DISSOCIATION | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE