4guy:A (ASN126) to (TYR262) HUMAN MMP12 CATALYTIC DOMAIN IN COMPLEX WITH*N*-HYDROXY-2-(2-(4- METHOXYPHENYL)ETHYLSULFONAMIDO)ACETAMIDE | MMP-12, MATRIX, METALLOPROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rts:A (ASN126) to (TYR262) HUMAN MMP-12 CATALYTIC DOMAIN IN COMPLEX WITH*N*-HYDROXY-2-(2- PHENYLETHYLSULFONAMIDO)ACETAMIDE | MMP-12, MATRIX METALLOPROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rtt:A (ASN126) to (TYR262) HUMAN MMP-12 CATALYTIC DOMAIN IN COMPLEX WITH*(R)-N*-HYDROXY-1- (PHENETHYLSULFONYL)PYRROLIDINE-2-CARBOXAMIDE | MMP-12, MATRIX, METALLOPROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ehy:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR (R)-2-(4- METHOXYPHENYLSULFONAMIDO)PROPANOIC ACID | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE,, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3ehx:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR (R)-2-(BIPHENYL-4- YLSULFONAMIDO)-4-METHYLPENTANOIC ACID | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE,, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
4h1q:A (PRO133) to (TYR268) CRYSTAL STRUCTURE OF MUTANT MMP-9 CATALYTIC DOMAIN IN COMPLEX WITH A TWIN INHIBITOR. | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h1q:B (ARG134) to (TYR268) CRYSTAL STRUCTURE OF MUTANT MMP-9 CATALYTIC DOMAIN IN COMPLEX WITH A TWIN INHIBITOR. | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h2e:B (ARG134) to (TYR268) CRYSTAL STRUCTURE OF AN MMP TWIN INHIBITOR COMPLEXING TWO MMP-9 CATALYTIC DOMAINS | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h30:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. | DIVALENT INHIBITOR, CARBOXYLIC TWIN INHIBITOR, DIMERISATION, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBTIOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h30:B (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. | DIVALENT INHIBITOR, CARBOXYLIC TWIN INHIBITOR, DIMERISATION, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBTIOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3x:A (ARG134) to (TYR268) CRYSTAL STRUCTURE OF AN MMP BROAD SPECTRUM HYDROXAMATE BASED INHIBITOR CC27 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN | HYDROLASE/HYDROXAMATE INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h3x:B (PRO133) to (GLY269) CRYSTAL STRUCTURE OF AN MMP BROAD SPECTRUM HYDROXAMATE BASED INHIBITOR CC27 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN | HYDROLASE/HYDROXAMATE INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h49:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. | DIVALENT INHIBITOR, CARBOXYLIC TWIN INHIBITOR, DIMERISATION, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h49:B (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. | DIVALENT INHIBITOR, CARBOXYLIC TWIN INHIBITOR, DIMERISATION, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h49:C (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. | DIVALENT INHIBITOR, CARBOXYLIC TWIN INHIBITOR, DIMERISATION, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h49:D (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. | DIVALENT INHIBITOR, CARBOXYLIC TWIN INHIBITOR, DIMERISATION, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ovx:A (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH BARBITURATE INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ovx:B (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH BARBITURATE INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ovz:A (ARG134) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH PHOSPHINATE INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ovz:B (ARG134) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH PHOSPHINATE INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ow0:A (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH IODINE-LABELED CARBOXYLATE INHIBITOR | MATRIX METALLOPROTEINASE, HYDROLASE, S1-PRIME POCKET
2ow0:B (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH IODINE-LABELED CARBOXYLATE INHIBITOR | MATRIX METALLOPROTEINASE, HYDROLASE, S1-PRIME POCKET
2ow1:A (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH TRIFLUOROMETHYL HYDROXAMATE INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ow1:B (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH TRIFLUOROMETHYL HYDROXAMATE INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ow2:A (ARG134) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH DIFLUORO BUTANOIC ACID INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ow2:B (PRO133) to (TYR443) MMP-9 ACTIVE SITE MUTANT WITH DIFLUORO BUTANOIC ACID INHIBITOR | MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ow9:A (THR109) to (TYR245) CRYSTAL STRUCTURE ANALYSIS OF THE MMP13 CATALYTIC DOMAIN IN COMPLEX WITH SPECIFIC INHIBITOR | COMPLEX CRYSTAL STRUCTURE, MARTIX METALLOPROTEINASE, MMP13, SPECIFIC MMP13 INHIBITOR, S1' MMP13 INHIBITOR, HYDROLASE
2ow9:B (THR109) to (TYR245) CRYSTAL STRUCTURE ANALYSIS OF THE MMP13 CATALYTIC DOMAIN IN COMPLEX WITH SPECIFIC INHIBITOR | COMPLEX CRYSTAL STRUCTURE, MARTIX METALLOPROTEINASE, MMP13, SPECIFIC MMP13 INHIBITOR, S1' MMP13 INHIBITOR, HYDROLASE
3elm:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF MMP-13 COMPLEXED WITH INHIBITOR 24F | METALLO-ENZYME, MMP-13, CARBOXYLATE INHIBITOR, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3elm:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF MMP-13 COMPLEXED WITH INHIBITOR 24F | METALLO-ENZYME, MMP-13, CARBOXYLATE INHIBITOR, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
4h76:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH A BROAD SPECTRUM HYDROXAMATE INHIBITOR | BROAD SPECTRUM MMP HYDROXAMATE INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2oxu:A (ASN126) to (TYR262) UNINHIBITED FORM OF HUMAN MMP-12 | MMP-12, MATRIX METALLOPROTEINASE, HYDROLASE
2oxw:A (ASN126) to (TYR262) HUMAN MMP-12 COMPLEXED WITH THE PEPTIDE IAG | MMP-12, MATRIX METALLOPROTEINASE, HYDROLASE
4h84:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH A SELECTIVE CARBOXYLATE BASED INHIBITOR. | SELECTIVE CARBOXYLATE BASED MMP-12 INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h84:B (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH A SELECTIVE CARBOXYLATE BASED INHIBITOR. | SELECTIVE CARBOXYLATE BASED MMP-12 INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2oy4:A (SER105) to (TYR241) UNINHIBITED HUMAN MMP-8 | MMP-8, MATRIX METALLOPROTEINASE, HYDROLASE
2oy4:F (SER105) to (GLY242) UNINHIBITED HUMAN MMP-8 | MMP-8, MATRIX METALLOPROTEINASE, HYDROLASE
2ozr:A (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:B (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:C (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:D (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:E (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:F (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:G (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
2ozr:H (THR109) to (TYR245) MMP13 CATALYTIC DOMAIN COMPLEXED WITH 4-{[1-METHYL-2,4-DIOXO-6-(3- PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CRYSTAL COMPLEX STRUCTURE, MATRIX METALLOPROTEINASE, MMP13 CATALYTIC DOMAIN, MMP13 SPECIFIC INHIBITOR, HYDROLASE
1b3d:B (LYS110) to (TYR246) STROMELYSIN-1 | STROMELYSIN, MATRIX METALLOPROTEINASE, OSTEOARTHRITIS, PROTEIN CRYSTAL STRUCTURE, STRUCTURE-BASED DRUG DESIGN, PROTEIN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4wzv:A (PRO133) to (GLY269) CRYSTAL STRUCTURE OF A HYDROXAMATE BASED INHIBITOR EN140 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN | MMP9 INHIBITOR COMPLEX, THYROID HORMONE-BINDING PROTEIN, HYDROLASE
4wzv:B (PRO133) to (TYR268) CRYSTAL STRUCTURE OF A HYDROXAMATE BASED INHIBITOR EN140 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN | MMP9 INHIBITOR COMPLEX, THYROID HORMONE-BINDING PROTEIN, HYDROLASE
1biw:A (PRO109) to (TYR246) DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS | STROMELYSIN, MATRIX METALLOPROTEASE, OSTEOARTHRITIS, STRUCTURE-BASED DRUG DESIGN, PROTEIN CRYSTAL STRUCTURE, HYDROLASE
1biw:B (LYS110) to (TYR246) DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS | STROMELYSIN, MATRIX METALLOPROTEASE, OSTEOARTHRITIS, STRUCTURE-BASED DRUG DESIGN, PROTEIN CRYSTAL STRUCTURE, HYDROLASE
4hma:A (PRO133) to (TYR268) CRYSTAL STRUCTURE OF AN MMP TWIN CARBOXYLATE BASED INHIBITOR LC20 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hma:B (PRO133) to (GLY269) CRYSTAL STRUCTURE OF AN MMP TWIN CARBOXYLATE BASED INHIBITOR LC20 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3f16:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR (R)-N-(3-HYDROXY-1-NITROSO-1- OXOPROPAN-2-YL)-4-METHOXYBENZENESULFONAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3f17:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR N-(2-NITROSO-2-OXOETHYL) BIPHENYL-4-SULFONAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3f18:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR 4-FLUORO-N-(2-HYDROXYETHYL)-N- (2-NITROSO-2-OXOETHYL)BENZENESULFONAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3f19:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR 4-FLUORO-N-(2-NITROSO-2- OXOETHYL)BENZENESULFONAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3f1a:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR N-(2-NITROSO-2-OXOETHYL) BENZENESULFONAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
1bqo:B (ALA112) to (TYR246) DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS | STROMELYSIN, MATRIX METALLOPROTEASE, OSTEOARTHRITIS, STRUCTURE-BASED DRUG DESIGN, METALLOPROTEASE
1bzs:A (SER105) to (GLY242) CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909 | METALLO PROTEINASE, HYDROXAMATE, MATRIX DEGRADATION, HYDROLASE
2pjt:A (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-344 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1',P1' GROUP, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, POLYMORPHISM, SECRETED, ZYMOGEN
2pjt:B (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-344 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1',P1' GROUP, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, POLYMORPHISM, SECRETED, ZYMOGEN
2pjt:C (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-344 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1',P1' GROUP, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, POLYMORPHISM, SECRETED, ZYMOGEN
2pjt:D (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-344 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1',P1' GROUP, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, POLYMORPHISM, SECRETED, ZYMOGEN
4xct:A (ARG134) to (TYR268) CRYSTAL STRUCTURE OF A HYDROXAMATE BASED INHIBITOR ARP101 (EN73) IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN. | INHIBITOR-COMPLEX, METALLOPROTEASE, HYDROLASE
1c3i:A (LYS110) to (TYR246) HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | STROMELYSIN-1, SITE MUTANT (GLU202-GLN), HYDROLASE
1c3i:B (LYS110) to (TYR246) HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | STROMELYSIN-1, SITE MUTANT (GLU202-GLN), HYDROLASE
4i03:A (ASN126) to (TYR262) HUMAN MMP12 IN COMPLEX WITH A PEG-LINKED BIFUNCTIONAL L-GLUTAMATE MOTIF INHIBITOR | SELECTIVE CARBOXYLATE BASED MMP-12 BIFUNCTIONAL INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2poj:A (ASN126) to (TYR262) NMR SOLUTION STRUCTURE OF THE INHIBITOR-FREE STATE OF MACROPHAGE METALLOELASTASE (MMP-12) | INHIBITOR-FREE SOLUTION STRUCTURE, MATRIX METALOPROTEINASE, MACROPHAGE METALLOELASTASE, MMP-12, HYDROLASE
1c8t:A (LYS110) to (TYR246) HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | PROTEIN-INHIBITOR COMPLEX, MUTANT PROTEIN, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1c8t:B (LYS110) to (TYR246) HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | PROTEIN-INHIBITOR COMPLEX, MUTANT PROTEIN, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
3shi:A (ARG127) to (TYR260) CRYSTAL STRUCTURE OF HUMAN MMP1 CATALYTIC DOMAIN AT 2.2 A RESOLUTION | MATRIX METALLOPROTEINASE, PARAMAGNETIC RESTRAINTS, PARAMAGNETIC TAG, LANTHANIDES, PROTEIN REFINEMENT, RESIDUAL DIPOLAR COUPLINGS, HYDROLASE
3shi:G (ARG127) to (TYR260) CRYSTAL STRUCTURE OF HUMAN MMP1 CATALYTIC DOMAIN AT 2.2 A RESOLUTION | MATRIX METALLOPROTEINASE, PARAMAGNETIC RESTRAINTS, PARAMAGNETIC TAG, LANTHANIDES, PROTEIN REFINEMENT, RESIDUAL DIPOLAR COUPLINGS, HYDROLASE
3shi:M (ARG127) to (TYR260) CRYSTAL STRUCTURE OF HUMAN MMP1 CATALYTIC DOMAIN AT 2.2 A RESOLUTION | MATRIX METALLOPROTEINASE, PARAMAGNETIC RESTRAINTS, PARAMAGNETIC TAG, LANTHANIDES, PROTEIN REFINEMENT, RESIDUAL DIPOLAR COUPLINGS, HYDROLASE
1cge:A (ARG127) to (TYR260) CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF | HYDROLASE (METALLOPROTEASE)
1cgf:A (PRO126) to (TYR260) CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF | HYDROLASE (METALLOPROTEASE)
1cgl:B (PRO126) to (TYR260) STRUCTURE OF THE CATALYTIC DOMAIN OF FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR | METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1oo9:A (PRO109) to (TYR246) ORIENTATION IN SOLUTION OF MMP-3 CATALYTIC DOMAIN AND N- TIMP-1 FROM RESIDUAL DIPOLAR COUPLINGS | PROTEIN-PROTEIN COMPLEX, HYDROLASE
1ciz:A (LYS110) to (TYR246) X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY | MATRIX METALLOPROTEINASE, MMP-3, NON-PEPTIDE INHIBITOR, METALLOPROTEINASE
1os2:A (ASN126) to (TYR262) TERNARY ENZYME-PRODUCT-INHIBITOR COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os2:B (ASN126) to (TYR262) TERNARY ENZYME-PRODUCT-INHIBITOR COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os2:C (ASN126) to (TYR262) TERNARY ENZYME-PRODUCT-INHIBITOR COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os2:D (ASN126) to (TYR262) TERNARY ENZYME-PRODUCT-INHIBITOR COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os2:F (ASN126) to (TYR262) TERNARY ENZYME-PRODUCT-INHIBITOR COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os9:A (ASN126) to (TYR262) BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os9:B (ASN126) to (TYR262) BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os9:C (ASN126) to (TYR262) BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os9:D (ASN126) to (TYR262) BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os9:E (ASN126) to (TYR262) BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1os9:F (ASN126) to (TYR262) BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12 | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, HYDROLASE
1cqr:B (PRO109) to (TYR246) CRYSTAL STRUCTURE OF THE STROMELYSIN CATALYTIC DOMAIN AT 2.0 A RESOLUTION | ACTIVE, TRUNCATED NATIVE ENZYME, HYDROLASE
1cxv:A (SER109) to (TYR245) STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13) | METALLOPROTEASE, GLYCOPROTEIN, COLLAGEN DEGRADATION, HYDROLASE
1cxv:B (SER409) to (TYR545) STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13) | METALLOPROTEASE, GLYCOPROTEIN, COLLAGEN DEGRADATION, HYDROLASE
1d5j:A (PRO109) to (TYR246) CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR. | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1d5j:B (LYS610) to (TYR746) CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR. | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
4ijo:A (ASN126) to (TYR262) UNRAVELING HIDDEN ALLOSTERIC REGULATORY SITES IN STRUCTURALLY HOMOLOGUES METALLOPROTEASES | MATRIX METALLOPROTEINASE, HYDROLASE, DEGRADATION OF THE EXTRACELLULAR MATRIX PROTEINS, AMPHIPHOLS, REGULATORY SITES, EXTRACELLULAR
4ilw:D (ARG126) to (TYR262) COMPLEX OF MATRIX METALLOPROTEINASE-10 CATALYTIC DOMAIN (MMP-10CD) WITH TISSUE INHIBITOR OF METALLOPROTEINASES-2 (TIMP-2) | METZINCIN, OB-FOLD, METALLOPROTEINASE, PROTEASE INHIBITOR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4ilw:F (ARG126) to (TYR262) COMPLEX OF MATRIX METALLOPROTEINASE-10 CATALYTIC DOMAIN (MMP-10CD) WITH TISSUE INHIBITOR OF METALLOPROTEINASES-2 (TIMP-2) | METZINCIN, OB-FOLD, METALLOPROTEINASE, PROTEASE INHIBITOR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2clt:A (ARG108) to (TYR241) CRYSTAL STRUCTURE OF THE ACTIVE FORM (FULL-LENGTH) OF HUMAN FIBROBLAST COLLAGENASE. | EXTRACELLULAR MATRIX, FIBROBLAST COLLAGENASE, ZINC, CALCIUM, ZYMOGEN, PROTEASE, COLLAGEN, AUTOCATALYTIC CLEAVAGE, MATRIX METALLOPROTEINASES, HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, INHIBITOR-FREE, METALLOPROTEASE, COLLAGEN DEGRADATION
2clt:B (ARG108) to (TYR241) CRYSTAL STRUCTURE OF THE ACTIVE FORM (FULL-LENGTH) OF HUMAN FIBROBLAST COLLAGENASE. | EXTRACELLULAR MATRIX, FIBROBLAST COLLAGENASE, ZINC, CALCIUM, ZYMOGEN, PROTEASE, COLLAGEN, AUTOCATALYTIC CLEAVAGE, MATRIX METALLOPROTEINASES, HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, INHIBITOR-FREE, METALLOPROTEASE, COLLAGEN DEGRADATION
2d1n:A (THR130) to (TYR266) COLLAGENASE-3 (MMP-13) COMPLEXED TO A HYDROXAMIC ACID INHIBITOR | HYDOROLASE METALLOPROTEASE, HYDROLASE
2d1n:B (THR130) to (TYR266) COLLAGENASE-3 (MMP-13) COMPLEXED TO A HYDROXAMIC ACID INHIBITOR | HYDOROLASE METALLOPROTEASE, HYDROLASE
2d1o:A (LYS110) to (TYR246) STROMELYSIN-1 (MMP-3) COMPLEXED TO A HYDROXAMIC ACID INHIBITOR | HYDOROLASE METALLOPROTEASE, HYDROLASE
2d1o:B (LYS110) to (TYR246) STROMELYSIN-1 (MMP-3) COMPLEXED TO A HYDROXAMIC ACID INHIBITOR | HYDOROLASE METALLOPROTEASE, HYDROLASE
1q3a:A (ARG126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MATRIX METALLOPROTEINASE 10 | MMP-10, METALLOPROTEINASE, INHIBITORS, NNGH, STROMELYSIN-2, HYDROXAMIC ACID, HYDROLASE
1q3a:B (PRO125) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MATRIX METALLOPROTEINASE 10 | MMP-10, METALLOPROTEINASE, INHIBITORS, NNGH, STROMELYSIN-2, HYDROXAMIC ACID, HYDROLASE
4ja1:A (LYS110) to (TYR246) STRUCTURE OF MMP3 COMPLEXED WITH A PLATINUM-BASED INHIBITOR | MATRIX METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ja1:B (LYS110) to (TYR246) STRUCTURE OF MMP3 COMPLEXED WITH A PLATINUM-BASED INHIBITOR | MATRIX METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ts4:A (ARG127) to (TYR262) HUMAN MMP12 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR | PSEUDO DIPEPTIDES, POTENT INHIBITORS, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tsk:A (ARG127) to (TYR262) HUMAN MMP12 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR | PSEUDO DIPEPTIDES, POTENT INHIBITORS, METZINCIN, ZINC METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1qia:B (PRO109) to (TYR246) CRYSTAL STRUCTURE OF STROMELYSIN CATALYTIC DOMAIN | INHIBITOR, MATRIXIN, MATRIX METALLOPROTEINASE-3 (MMP-3), STROMELYSIN- 1, METZINCIN, HYDROLASE
1qia:C (LYS110) to (TYR246) CRYSTAL STRUCTURE OF STROMELYSIN CATALYTIC DOMAIN | INHIBITOR, MATRIXIN, MATRIX METALLOPROTEINASE-3 (MMP-3), STROMELYSIN- 1, METZINCIN, HYDROLASE
3tvc:A (THR130) to (TYR266) HUMAN MMP13 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR | PSEUDO DIPEPTIDES, POTENT INHIBITORS, METZINCIN, ZINC METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jp4:A (THR130) to (TYR266) MMP13 IN COMPLEX WITH A REVERSE HYDROXAMATE ZN-BINDER | MATRIX METALLOPROTEASE, CALCIUM BINDING, ZINC BINDING, HYDROLASE
4jp4:B (THR130) to (TYR266) MMP13 IN COMPLEX WITH A REVERSE HYDROXAMATE ZN-BINDER | MATRIX METALLOPROTEASE, CALCIUM BINDING, ZINC BINDING, HYDROLASE
4jpa:A (THR130) to (TYR266) MMP13 IN COMPLEX WITH A PIPERAZINE HYDANTOIN LIGAND | MATRIX METALLOPROTEASE, CALCIUM BINDING, ZINC BINDING, HYDROLASE
4jpa:B (THR130) to (TYR266) MMP13 IN COMPLEX WITH A PIPERAZINE HYDANTOIN LIGAND | MATRIX METALLOPROTEASE, CALCIUM BINDING, ZINC BINDING, HYDROLASE
2tcl:A (ARG27) to (TYR160) STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR | HYDROLASE (METALLOPROTEASE)
1fbl:A (ARG127) to (TYR260) STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE (MMP1) REVEALS A C-TERMINAL DOMAIN CONTAINING A CALCIUM-LINKED, FOUR-BLADED BETA- PROPELLER | METALLOPROTEASE
1fls:A (HIS28) to (GLY164) SOLUTION STRUCTURE OF THE CATALYTIC FRAGMENT OF HUMAN COLLAGENASE-3 (MMP-13) COMPLEXED WITH A HYDROXAMIC ACID INHIBITOR | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, HUMAN COLLAGENASE-3, MMP-13, HYDROLASE
1rm8:A (ASP145) to (TYR290) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-16/MT3- MMP: CHARACTERIZATION OF MT-MMP SPECIFIC FEATURES | MMP-16, MT3-MMP, MT-MMP, MEMBRANE TYPE - MATRIX METALLOPROTEINASE, BATIMASTAT, HYDROXAMATE INHIBITOR, PROTEASE, HYDROLASE
1rmz:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR NNGH AT 1.3 A RESOLUTION | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, NNGH, HYDROLASE
1ros:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2-(1,3-DIOXO-1,3- DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4- YL)-4-OXOBUTANOIC ACID | MACROPHAGE METALLOELASTASE, NON-ZINC CHELATOR, MMP-12, MMP12 INHIBITOR, HYDROLASE
1ros:B (ARG127) to (TYR262) CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2-(1,3-DIOXO-1,3- DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4- YL)-4-OXOBUTANOIC ACID | MACROPHAGE METALLOELASTASE, NON-ZINC CHELATOR, MMP-12, MMP12 INHIBITOR, HYDROLASE
1g05:A (LYS110) to (TYR246) HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1g05:B (LYS610) to (TYR746) HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1g49:A (LYS110) to (TYR246) A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1g49:B (LYS610) to (TYR746) A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1g4k:A (LYS110) to (TYR246) X-RAY STRUCTURE OF A NOVEL MATRIX METALLOPROTEINASE INHIBITOR COMPLEXED TO STROMELYSIN | STOMELYSIN, MMP, ZINC LIGAND, HYDROLASE
1g4k:B (LYS110) to (TYR246) X-RAY STRUCTURE OF A NOVEL MATRIX METALLOPROTEINASE INHIBITOR COMPLEXED TO STROMELYSIN | STOMELYSIN, MMP, ZINC LIGAND, HYDROLASE
1g4k:C (PRO109) to (TYR246) X-RAY STRUCTURE OF A NOVEL MATRIX METALLOPROTEINASE INHIBITOR COMPLEXED TO STROMELYSIN | STOMELYSIN, MMP, ZINC LIGAND, HYDROLASE
3uvc:A (ARG127) to (TYR262) MMP12 IN A COMPLEX WITH THE DIMERIC ADDUCT: 5-(5-PHENYLHYDANTOIN)-5- PHENYLHYDANTOIN | HYDROLASE, METALLOPROTEASE
3uvc:B (ASN126) to (TYR262) MMP12 IN A COMPLEX WITH THE DIMERIC ADDUCT: 5-(5-PHENYLHYDANTOIN)-5- PHENYLHYDANTOIN | HYDROLASE, METALLOPROTEASE
1gkc:A (ARG134) to (TYR443) MMP9-INHIBITOR COMPLEX | MATRIX METALLOPROTEASE, HYDROLASE, GLYCOPROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1gkc:B (PRO133) to (TYR443) MMP9-INHIBITOR COMPLEX | MATRIX METALLOPROTEASE, HYDROLASE, GLYCOPROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1gkd:A (ARG134) to (TYR443) MMP9 ACTIVE SITE MUTANT-INHIBITOR COMPLEX | MATRIX METALLOPROTEASE, HYDROLASE, GLYCOPROTEIN
1gkd:B (PRO133) to (TYR443) MMP9 ACTIVE SITE MUTANT-INHIBITOR COMPLEX | MATRIX METALLOPROTEASE, HYDROLASE, GLYCOPROTEIN
3v96:B (ARG126) to (TYR262) COMPLEX OF MATRIX METALLOPROTEINASE-10 CATALYTIC DOMAIN (MMP-10CD) WITH TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) | METZINCIN, OB-FOLD, METALLOPROTEINASE, PROTEASE INHIBITOR, HYDROLASE INHIBITOR-HYDROLASE COMPLEX
1slm:A (LYS110) to (TYR246) CRYSTAL STRUCTURE OF FIBROBLAST STROMELYSIN-1: THE C-TRUNCATED HUMAN PROENZYME | HYDROLASE, METALLOPROTEASE, FIBROBLAST, COLLAGEN DEGRADATION
1sln:A (LYS110) to (TYR246) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-702,842 | HYDROLASE, METALLOPROTEASE, FIBROBLAST, COLLAGEN DEGRADATION
1su3:A (ARG127) to (TYR260) X-RAY STRUCTURE OF HUMAN PROMMP-1: NEW INSIGHTS INTO COLLAGENASE ACTION | PRODOMAIN, HEMOPEXIN DOMAIN, EXOCITE, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
1su3:B (ARG127) to (TYR260) X-RAY STRUCTURE OF HUMAN PROMMP-1: NEW INSIGHTS INTO COLLAGENASE ACTION | PRODOMAIN, HEMOPEXIN DOMAIN, EXOCITE, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
3i7i:A (THR130) to (TYR266) MMP-13 IN COMPLEX WITH A NON ZINC-CHELATING INHIBITOR | PROTEASE, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, SECRETED, ZINC, ZYMOGEN
3i7i:B (THR130) to (TYR266) MMP-13 IN COMPLEX WITH A NON ZINC-CHELATING INHIBITOR | PROTEASE, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, SECRETED, ZINC, ZYMOGEN
4l19:A (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH SELECTIVE INHIBITOR COMPOUND Q1 | METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, EXOSITE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4l19:B (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH SELECTIVE INHIBITOR COMPOUND Q1 | METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, EXOSITE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hfc:A (ARG127) to (TYR260) 1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE | METALLOPROTEASE
1hfs:A (PRO109) to (TYR246) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-764,004 | HYDROLASE, METALLOPROTEASE, MATRIX METALLOPROTEASE-3, PROTEOGLYCANASE
1hov:A (GLU30) to (TYR162) SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 | ENZYME-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1hy7:A (LYS110) to (TYR246) A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1hy7:B (LYS610) to (TYR746) A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
2wo9:A (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2wo9:B (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2wo9:C (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2wo9:D (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2woa:A (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, DISULFIDE BOND, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZINC, CALCIUM, ZYMOGEN, PROTEASE, SECRETED
2woa:B (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, DISULFIDE BOND, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZINC, CALCIUM, ZYMOGEN, PROTEASE, SECRETED
2woa:C (ASN126) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, DISULFIDE BOND, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZINC, CALCIUM, ZYMOGEN, PROTEASE, SECRETED
2woa:D (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, DISULFIDE BOND, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZINC, CALCIUM, ZYMOGEN, PROTEASE, SECRETED
2hu6:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF HUMAN MMP-12 IN COMPLEX WITH ACETOHYDROXAMIC ACID AND A BICYCLIC INHIBITOR | MMP-12, MATRIX METALLOPROTEINASE, MACROPHAGE METALLOELASTASE, INHIBITOR, HYDROXAMIC ACID, DRUG DESIGN, HYDROLASE
1i73:A (SER105) to (TYR241) COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | METALLOPROTEASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1i76:A (SER105) to (ALA239) COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO- ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | HYDROLASE, COMPLEX (METALLOPROTEASE/INHIBITOR)
1umt:A (LYS110) to (GLY247) STROMELYSIN-1 CATALYTIC DOMAIN WITH HYDROPHOBIC INHIBITOR BOUND, PH 7.0, 32OC, 20 MM CACL2, 15% ACETONITRILE; NMR AVERAGE OF 20 STRUCTURES MINIMIZED WITH RESTRAINTS | ZINC HYDROLASE, METZINCIN, MATRIX METALLOPROTEINASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1utt:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2- (1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4- (4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID | MACROPHAGE METALLOELASTASE, NON-ZINC CHELATOR, MMP-12, MMP INHIBITOR, HYDROLASE, METALLOPROTEASE
1utz:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO (2R)-3-({[4-[(PYRI DIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID | MACROPHAGE METALLOELASTASE, NON-ZINC CHELATOR, MMP-12, MMP INHIBITOR, HYDROLASE, METALLOPROTEASE
1utz:B (ASN126) to (TYR262) CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO (2R)-3-({[4-[(PYRI DIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID | MACROPHAGE METALLOELASTASE, NON-ZINC CHELATOR, MMP-12, MMP INHIBITOR, HYDROLASE, METALLOPROTEASE
1jan:A (SER105) to (TYR241) COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM) | METALLOPROTEASE, ZINC-ENDOPEPTIDASE, METZINCINS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1jap:A (SER105) to (TYR241) COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | METALLOPROTEASE, ZINC-ENDOPEPTIDASE, METZINCINS, COMPLEX (METALLOPROTEASE/INHIBITOR) COMPLEX
1jaq:A (SER105) to (TYR241) COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | METALLOPROTEASE, ZINC-ENDOPEPTIDASE, METZINCINS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2j0t:A (ARG127) to (TYR260) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-1 IN COMPLEX WITH THE INHIBITORY DOMAIN OF TIMP-1 | EXTRACELLULAR MATRIX, ERYTHROCYTE MATURATION, AUTOCATALYTIC CLEAVAGE, COLLAGEN DEGRADATION, HYDROLASE,
2j0t:B (PRO126) to (TYR260) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-1 IN COMPLEX WITH THE INHIBITORY DOMAIN OF TIMP-1 | EXTRACELLULAR MATRIX, ERYTHROCYTE MATURATION, AUTOCATALYTIC CLEAVAGE, COLLAGEN DEGRADATION, HYDROLASE,
2j0t:C (PRO126) to (TYR260) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-1 IN COMPLEX WITH THE INHIBITORY DOMAIN OF TIMP-1 | EXTRACELLULAR MATRIX, ERYTHROCYTE MATURATION, AUTOCATALYTIC CLEAVAGE, COLLAGEN DEGRADATION, HYDROLASE,
1jiz:A (ASN27) to (TYR163) CRYSTAL STRUCTURE ANALYSIS OF HUMAN MACROPHAGE ELASTASE MMP- 12 | MATRIX METALLOPROTEINASE, MMP-12, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, HYDROLASE
1jiz:B (ASN27) to (TYR163) CRYSTAL STRUCTURE ANALYSIS OF HUMAN MACROPHAGE ELASTASE MMP- 12 | MATRIX METALLOPROTEINASE, MMP-12, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, HYDROLASE
1jj9:A (SER105) to (GLY242) CRYSTAL STRUCTURE OF MMP8-BARBITURATE COMPLEX REVEALS MECHANISM FOR COLLAGEN SUBSTRATE RECOGNITION | MMP-8, SUBSTRATE RECOGNITION, CIS-PEPTIDE BOND, CONFORMATIONAL TRANSITION, HYDROLASE
3wv2:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH N- (3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXAMIDE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wv2:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH N- (3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXAMIDE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wv3:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH N- (3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-2- CARBOXAMIDE | MMP-13, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wv3:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH N- (3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-2- CARBOXAMIDE | MMP-13, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5bot:A (THR130) to (TYR266) X-RAY CO-STRUCTURE OF MMP-13 WITH ETHYL 5-CARBAMOYL-1H-INDOLE-2- CARBOXYLATE | RIDGEFIELD, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5bot:B (THR130) to (TYR266) X-RAY CO-STRUCTURE OF MMP-13 WITH ETHYL 5-CARBAMOYL-1H-INDOLE-2- CARBOXYLATE | RIDGEFIELD, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5boy:B (THR130) to (TYR266) X-RAY CO-STRUCTURE OF MMP-13 WITH ETHYL 5-(1-METHYL-1H-IMIDAZOL-5-YL)- 1H-INDOLE-2-CARBOXYLATE | RIDGEFIELD, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5bpa:A (THR130) to (TYR266) X-RAY CO-STRUCTURE OF MMP-13 WITH 4-[({5-[2-(ETHOXYCARBONYL)-1H-INDOL- 5-YL]-1-METHYL-1H-PYRAZOL-3-YL}FORMAMIDO)METHYL]BENZOATE | RIDGEFIELD, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5bpa:B (THR130) to (TYR266) X-RAY CO-STRUCTURE OF MMP-13 WITH 4-[({5-[2-(ETHOXYCARBONYL)-1H-INDOL- 5-YL]-1-METHYL-1H-PYRAZOL-3-YL}FORMAMIDO)METHYL]BENZOATE | RIDGEFIELD, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2jnp:A (PRO109) to (TYR246) SOLUTION STRUCTURE OF MATRIX METALLOPROTEINASE 3 (MMP-3) IN THE PRESENCE OF N-ISOBUTYL-N-[4- METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID (NNGH) | METALLOPROTEINASE, NMR, MMP, HYDROLASE
1kbc:A (SER105) to (TYR241) PROCARBOXYPEPTIDASE TERNARY COMPLEX | HYDROLYTIC ENZYME, METALLOPROTEINASE, COLLAGENASE, MATRIXIN, MMP-8, HNC, INHIBITOR, HYDROLASE
1kbc:B (GLU106) to (TYR241) PROCARBOXYPEPTIDASE TERNARY COMPLEX | HYDROLYTIC ENZYME, METALLOPROTEINASE, COLLAGENASE, MATRIXIN, MMP-8, HNC, INHIBITOR, HYDROLASE
2mze:A (ASN114) to (GLY239) NMR SOLUTION STRUCTURE OF THE PRO FORM OF HUMAN MATRILYSIN (PROMMP-7) | ZYMOGEN, HYDROLASE, METALLOENZYME
2mzi:A (HIS102) to (TYR238) NMR SOLUTION STRUCTURE OF THE PRO FORM OF HUMAN MATRILYSIN (PROMMP-7) IN COMPLEX WITH ANIONIC MEMBRANE | ZYMOGEN, HYDROLASE, MEMBRANE-BOUND FORM, METALLOENZYME, ANIONIC
3zxh:A (THR130) to (TYR266) MMP-13 COMPLEXED WITH 2-NAPTHYLSULFONAMIDE HYDROXAMIC ACID INHIBITOR | METALLO-ENZYME, CARBOXYLATE INHIBITOR, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, HYDROLASE, METAL-BINDING, METALLOPROTEASE
3zxh:B (THR130) to (TYR266) MMP-13 COMPLEXED WITH 2-NAPTHYLSULFONAMIDE HYDROXAMIC ACID INHIBITOR | METALLO-ENZYME, CARBOXYLATE INHIBITOR, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, HYDROLASE, METAL-BINDING, METALLOPROTEASE
2yig:A (THR130) to (TYR266) MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR | HYDROLASE, COLLAGENASE 3, MMP-13, MATRIXMETALLOPROTEASE
2yig:B (THR130) to (TYR266) MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR | HYDROLASE, COLLAGENASE 3, MMP-13, MATRIXMETALLOPROTEASE
456c:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID | HYDROLASE, MATRIX METALLOPROTEASE
456c:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID | HYDROLASE, MATRIX METALLOPROTEASE
2z2d:A (ASN126) to (TYR262) SOLUTION STRUCTURE OF HUMAN MACROPHAGE ELASTASE (MMP-12) CATALYTIC DOMAIN COMPLEXED WITH A GAMMA-KETO BUTANOIC ACID INHIBITOR | HUMAN MACROPHAGE ELASTASE,COMPLEX, SOLUTION STRUCTURE, HYDROLASE
4a7b:A (THR130) to (TYR266) MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD22 | HYDROLASE
4a7b:B (THR130) to (TYR266) MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD22 | HYDROLASE
5cuh:A (ARG134) to (GLY269) CRYSTAL STRUCTURE MMP-9 COMPLEXES WITH A CONSTRAINED HYDROXAMATE BASED INHIBITOR LT4 | MMP-9 HYDROXAMATE-BASED INHIBITOR GELATINASE, HYDROLASE
5cuh:B (ARG134) to (TYR268) CRYSTAL STRUCTURE MMP-9 COMPLEXES WITH A CONSTRAINED HYDROXAMATE BASED INHIBITOR LT4 | MMP-9 HYDROXAMATE-BASED INHIBITOR GELATINASE, HYDROLASE
3kec:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH A PHENYL-2H-TETRAZOLE COMPOUND | S1' INHIBITOR; SELECTIVE MMP-13 INHIBITOR; S1' SPECIFICITY POCKET; NO CONTACT TO ZN, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kec:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH A PHENYL-2H-TETRAZOLE COMPOUND | S1' INHIBITOR; SELECTIVE MMP-13 INHIBITOR; S1' SPECIFICITY POCKET; NO CONTACT TO ZN, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kej:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH A (PYRIDIN-4-YL)-2H- TETRAZOLE COMPOUND | S1' INHIBITOR, SELECTIVE MMP-13 INHIBITOR, S1' SPECIFICITY POCKET, NO CONTACT TO ZN, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kej:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH A (PYRIDIN-4-YL)-2H- TETRAZOLE COMPOUND | S1' INHIBITOR, SELECTIVE MMP-13 INHIBITOR, S1' SPECIFICITY POCKET, NO CONTACT TO ZN, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kek:A (THR130) to (GLY267) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH A (PYRIDIN-4-YL)-2H- TETRAZOLE COMPOUND | S1' INHIBITOR; SELECTIVE MMP-13 INHIBITOR; S1' SPECIFICITY, NO CONTACT TO ZN, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kek:B (THR130) to (GLY267) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH A (PYRIDIN-4-YL)-2H- TETRAZOLE COMPOUND | S1' INHIBITOR; SELECTIVE MMP-13 INHIBITOR; S1' SPECIFICITY, NO CONTACT TO ZN, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xuc:A (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH NON-ZINC BINDING INHIBITOR | MATRIX METALLOPROTEINASE, NON-ZINC BINDING INHIBITOR, HYDROLASE
1xuc:B (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH NON-ZINC BINDING INHIBITOR | MATRIX METALLOPROTEINASE, NON-ZINC BINDING INHIBITOR, HYDROLASE
1xud:A (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH NON-ZINC BINDING INHIBITOR | MATRIX METALLOPROTEINASE, NON-ZINC BINDING INHIBITOR, HYDROLASE
1xud:B (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH NON-ZINC BINDING INHIBITOR | MATRIX METALLOPROTEINASE, NON-ZINC BINDING INHIBITOR, HYDROLASE
1xur:A (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH NON-ZINC BINDING INHIBITOR | MATRIX METALLOPROTEINASE, NON-ZINC BINDING INHIBITOR, HYDROLASE
1xur:B (THR130) to (TYR266) MATRIX METALLOPROTEINASE-13 COMPLEXED WITH NON-ZINC BINDING INHIBITOR | MATRIX METALLOPROTEINASE, NON-ZINC BINDING INHIBITOR, HYDROLASE
1mmb:A (SER105) to (TYR241) COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8 | HYDROLASE, METALLOPROTEASE, METZINCINS, COLLAGEN DEGRADATION, HYDROLASE (METALLOPROTEASE)
1mmp:A (PRO126) to (TYR262) MATRILYSIN COMPLEXED WITH CARBOXYLATE INHIBITOR | METALLOPROTEASE
1mmp:B (PRO126) to (TYR262) MATRILYSIN COMPLEXED WITH CARBOXYLATE INHIBITOR | METALLOPROTEASE
1mnc:A (SER126) to (TYR262) STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET | HYDROLASE (METALLOPROTEASE)
1y93:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH ACETOHYDROXAMIC ACID AT ATOMIC RESOLUTION | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE- INHIBITOR), METALLO ELASTASE, ACETOHYDROXAMIC ACID, HYDROLASE
1you:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH A POTENT PYRIMIDINETRIONE INHIBITOR | HYDROLASE, METALLOPROTEASE
1you:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH A POTENT PYRIMIDINETRIONE INHIBITOR | HYDROLASE, METALLOPROTEASE
3lik:A (ARG127) to (TYR262) HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR | MMP12 ELASTASE NON-CHELATING INHIBITOR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3lil:A (ASN126) to (TYR262) HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR | MMP12 ELASTASE NON-CHELATING INHIBITOR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3lir:A (ARG127) to (TYR262) HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR | MMP12 ELASTASE NON-CHELATING INHIBITOR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ljg:A (ASN126) to (TYR262) HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR | MMP12 ELASTASE NON-CHELATING INHIBITOR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ljz:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH AN AMINO-2-INDANOL COMPOUND | MMP-13 INHIBITOR; ZINC CHELATING AGENT; S1' POCKET, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ljz:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH AN AMINO-2-INDANOL COMPOUND | MMP-13 INHIBITOR; ZINC CHELATING AGENT; S1' POCKET, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ljz:C (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH AN AMINO-2-INDANOL COMPOUND | MMP-13 INHIBITOR; ZINC CHELATING AGENT; S1' POCKET, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ljz:D (THR130) to (TYR266) CRYSTAL STRUCTURE OF HUMAN MMP-13 COMPLEXED WITH AN AMINO-2-INDANOL COMPOUND | MMP-13 INHIBITOR; ZINC CHELATING AGENT; S1' POCKET, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3lk8:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR PARAMETHOXY-SULFONYL-GLYCINE HYDROXAMATE | MATRIX METALLOPROTEINASE, METALLO ELASTASE, ELASTASE INHIBITOR, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE
3lka:A (ASN126) to (TYR262) CATALYTIC DOMAIN OF HUMAN MMP-12 COMPLEXED WITH HYDROXAMIC ACID AND PARAMETHOXY-SULFONYL AMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE- INHIBITOR), METALLO ELASTASE, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE
1zs0:A (SER105) to (TYR241) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (S-ENANTIOMER) | PHOSPHONIC INHIBITOR, SULPHONAMIDE JUNCTION, STEREOSELECTIVE INHIBITION, HYDROLASE
1ztq:A (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-033 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1', P1' GROUP
1ztq:B (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-033 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1', P1' GROUP
1ztq:C (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-033 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1', P1' GROUP
1ztq:D (THR105) to (TYR241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH WAY-033 | MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1', P1' GROUP
4qkz:A (SER105) to (ALA239) X-RAY STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-8 WITH THE INHIBITOR ML115 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3n2u:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR N-HYDROXY-2-(4-METHOXY-N(2-(3,4,5-TRIHYDROXY-6- (HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YLOXY)ETHYL)PHENYLSULFONAMIDO) ACETAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE- INHIBITOR), METALLO ELASTASE, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-INDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3n2v:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR N-HYDROXY-2-(N-HYDROXYETHYL)BIPHENYL-4- YLSULFONAMIDO)ACETAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE- INHIBITOR), METALLO ELASTASE, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-INDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4r3v:A (THR59) to (TYR196) STRUCTURE OF KARILYSIN PROPEPTIDE AND CATALYTIC MMP DOMAIN | METZINCIN METALLOPEPTIDASE, MATRIX METALLOPROTEINASE WITH UNIQUE PROPEPTIDE, BACTERIAL MATRIX METALLOPROTEINASE-LIKE ENZYME, HYDROLASE
4r3v:B (THR59) to (GLY197) STRUCTURE OF KARILYSIN PROPEPTIDE AND CATALYTIC MMP DOMAIN | METZINCIN METALLOPEPTIDASE, MATRIX METALLOPROTEINASE WITH UNIQUE PROPEPTIDE, BACTERIAL MATRIX METALLOPROTEINASE-LIKE ENZYME, HYDROLASE
4c7g:A (SER36) to (LYS118) STRUCTURE AND ACTIVITY OF THE GH20 BETA-N- ACETYLHEXOSAMINIDASE FROM STREPTOMYCES COELICOLOR A3(2) | HYDROLASE, BETA-N-ACETYLHEXOSAMINIDASE, N-ACETYLHEXOSAMINIDES, CHITIN DEGRADATION, STREPTOMYCES COELICOLOR
3nx7:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR N-HYDROXY-2-(N-(2-HYDROXYETHYL)4- METHOXYPHENYLSULFONAMIDO)ACETAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE- INHIBITOR), HYDROLASE
3o2x:A (THR1130) to (TYR1266) MMP-13 IN COMPLEX WITH SELECTIVE TETRAZOLE CORE INHIBITOR | HYDROLASE
3o2x:B (THR2130) to (TYR2266) MMP-13 IN COMPLEX WITH SELECTIVE TETRAZOLE CORE INHIBITOR | HYDROLASE
3o2x:C (THR1130) to (TYR1266) MMP-13 IN COMPLEX WITH SELECTIVE TETRAZOLE CORE INHIBITOR | HYDROLASE
3o2x:D (THR2130) to (TYR2266) MMP-13 IN COMPLEX WITH SELECTIVE TETRAZOLE CORE INHIBITOR | HYDROLASE
3ohl:A (LYS110) to (TYR246) CATALYTIC DOMAIN OF STROMELYSIN-1 IN COMPLEX WITH N-HYDROXY-2-(4- METHOXY-N-(PYRIDINE-3-YLMETHYL)PHENYLSULFONAMIDO)ACETAMIDE | MATRIXMETALLOPROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oho:A (LYS110) to (TYR246) CATALYTIC DOMAIN OF STROMELYSIN-1 IN COMPLEX WITH N-HYDROXY-2-(4- METHYLPHENYLSULFONAMIDO)ACETAMIDE | MATRIXMETALLOPROTEINASE, HYDROLASE
3dng:A (SER105) to (GLY242) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON- ZINC CHELATING INHIBITOR | HYDROLASE, SELECTIVE INHIBITION, NON-ZINC CHELATING INHIBITORS, CALCIUM, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3dng:B (SER105) to (GLY242) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON- ZINC CHELATING INHIBITOR | HYDROLASE, SELECTIVE INHIBITION, NON-ZINC CHELATING INHIBITORS, CALCIUM, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3dpe:A (SER105) to (GLY242) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON- ZINC CHELATING INHIBITOR | HYDROLASE, SELECTIVE INHIBITION, NON-ZINC CHELATING INHIBITORS, CALCIUM, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3dpf:A (SER105) to (GLY242) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON- ZINC CHELATING INHIBITOR | HYDROLASE, SELECTIVE INHIBITION, NON-ZINC CHELATING INHIBITORS, CALCIUM, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
3dpf:B (SER105) to (GLY242) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON- ZINC CHELATING INHIBITOR | HYDROLASE, SELECTIVE INHIBITION, NON-ZINC CHELATING INHIBITORS, CALCIUM, COLLAGEN DEGRADATION, EXTRACELLULAR MATRIX, GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
5i12:A (ARG134) to (TYR268) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-9 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED ARYLSULFONAMIDE CARBOXYLATE WATER-SOLUBLE INHIBITOR (DC27). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i2z:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATING WATER-SOLUBLE INHIBITOR (DC24). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i2z:B (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATING WATER-SOLUBLE INHIBITOR (DC24). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i2z:C (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATING WATER-SOLUBLE INHIBITOR (DC24). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i2z:D (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATING WATER-SOLUBLE INHIBITOR (DC24). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i3m:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED THIOUREA-LINKED CARBOXYLATE ZINC-CHELATOR WATER-SOLUBLE INHIBITOR (DC31). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i3m:B (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED THIOUREA-LINKED CARBOXYLATE ZINC-CHELATOR WATER-SOLUBLE INHIBITOR (DC31). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i3m:C (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED THIOUREA-LINKED CARBOXYLATE ZINC-CHELATOR WATER-SOLUBLE INHIBITOR (DC31). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i3m:D (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED THIOUREA-LINKED CARBOXYLATE ZINC-CHELATOR WATER-SOLUBLE INHIBITOR (DC31). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i43:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATOR WATER-SOLUBLE INHIBITOR (DC32). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i43:B (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATOR WATER-SOLUBLE INHIBITOR (DC32). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i43:D (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE CHELATOR WATER-SOLUBLE INHIBITOR (DC32). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i4o:C (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE ZINC-CHELATOR WATER-SOLUBLE INHIBITOR (DC28). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i4o:D (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED TRIAZOLE-LINKED CARBOXYLATE ZINC-CHELATOR WATER-SOLUBLE INHIBITOR (DC28). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
4fu4:B (THR130) to (TYR266) HUMAN COLLAGENASE 3 (MMP-13) WITH PEPTIDE FROM PRO-DOMAIN | PROTEIN-PEPTIDE COMPLEX, COLLAGENASE, COLLAGEN, CLEAVAGE WITH MMP3, HYDROLASE, PRO-PEPTIDE, METZINCIN, ZINC METALLOPROTEASE, COLLAGEN CLEAVAGE
4fvl:A (THR130) to (TYR266) HUMAN COLLAGENASE 3 (MMP-13) FULL FORM WITH PEPTIDES FROM PRO-DOMAIN | PROTEIN-PEPTIDE COMPLEX, COLLAGENASE, CLEAVAGE WITH MMP3, HYDROLASE, PRO-PEPTIDE, METZINCIN, ZINC METALLOPROTEASE, COLLAGEN CLEAVAGE, COLLAGEN
4fvl:B (THR130) to (TYR266) HUMAN COLLAGENASE 3 (MMP-13) FULL FORM WITH PEPTIDES FROM PRO-DOMAIN | PROTEIN-PEPTIDE COMPLEX, COLLAGENASE, CLEAVAGE WITH MMP3, HYDROLASE, PRO-PEPTIDE, METZINCIN, ZINC METALLOPROTEASE, COLLAGEN CLEAVAGE, COLLAGEN
4g0d:B (THR130) to (TYR266) HUMAN COLLAGENASE 3 (MMP-13) FULL FORM WITH PEPTIDES FROM PRO-DOMAIN | PROTEIN-PEPTIDE COMPLEX, COLLAGENASE, CLEAVAGE WITH MMP3, HYDROLASE, PRO-PEPTIDE, METZINCIN, ZINC METALLOPROTEASE, COLLAGEN CLEAVAGE, COLLAGEN
4g0d:C (THR130) to (TYR266) HUMAN COLLAGENASE 3 (MMP-13) FULL FORM WITH PEPTIDES FROM PRO-DOMAIN | PROTEIN-PEPTIDE COMPLEX, COLLAGENASE, CLEAVAGE WITH MMP3, HYDROLASE, PRO-PEPTIDE, METZINCIN, ZINC METALLOPROTEASE, COLLAGEN CLEAVAGE, COLLAGEN
4g9l:A (LYS110) to (TYR246) STRUCTURE OF MMP3 COMPLEXED WITH NNGH INHIBITOR. | MATRIX METALLOPROTEASE, NNGH, PROTEASE, HYDROXAMIC ZINC-CHELATING INHIBITOR, EXTRACELLULAR MATRIX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4g9l:B (LYS110) to (TYR246) STRUCTURE OF MMP3 COMPLEXED WITH NNGH INHIBITOR. | MATRIX METALLOPROTEASE, NNGH, PROTEASE, HYDROXAMIC ZINC-CHELATING INHIBITOR, EXTRACELLULAR MATRIX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gql:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470.1 | POTENT SELECTIVE PHOSPHINIC INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gr0:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470B | POTENT SELECTIVE PHOSPHINIC INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gr3:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470A | POTENT SELECTIVE PHOSPHINIC INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5l7f:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF MMP12 MUTANT K421A IN COMPLEX WITH RXP470.1 CONJUGATED WITH FLUOROPHORE CY5,5 IN SPACE GROUP P21. | PROBES FOR OPTICAL IMAGING, MMP-12, METALLOPROTEASE, INFLAMMATION, ANEURYSM, FLUOROPHORE, CY5, 5, CYANINE, HYDROLASE
5l7f:B (ASN126) to (TYR262) CRYSTAL STRUCTURE OF MMP12 MUTANT K421A IN COMPLEX WITH RXP470.1 CONJUGATED WITH FLUOROPHORE CY5,5 IN SPACE GROUP P21. | PROBES FOR OPTICAL IMAGING, MMP-12, METALLOPROTEASE, INFLAMMATION, ANEURYSM, FLUOROPHORE, CY5, 5, CYANINE, HYDROLASE
830c:A (THR130) to (TYR266) COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID | MATRIX METALLOPROTEASE
830c:B (THR130) to (TYR266) COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID | MATRIX METALLOPROTEASE
1a85:A (SER105) to (TYR241) MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR | COLLAGENASE, MATRIX METALLOPROTEINASE, MALONIC ACID, MMP8, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1a86:A (SER105) to (TYR241) MMP8 WITH MALONIC AND ASPARTIC ACID BASED INHIBITOR | COLLAGENASE, MATRIX METALLOPROTEINASE, MALONIC ACID, MMP8, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4h82:A (ALA135) to (HIS266) CRYSTAL STRUCTURE OF MUTANT MMP-9 CATALYTIC DOMAIN IN COMPLEX WITH A TWIN INHIBITOR. | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h82:B (PRO133) to (TYR268) CRYSTAL STRUCTURE OF MUTANT MMP-9 CATALYTIC DOMAIN IN COMPLEX WITH A TWIN INHIBITOR. | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4h82:D (PRO133) to (GLY269) CRYSTAL STRUCTURE OF MUTANT MMP-9 CATALYTIC DOMAIN IN COMPLEX WITH A TWIN INHIBITOR. | HYDROLASE/TWIN INHIBITOR, ZINCIN-LIKE, GELATINASE, COLLAGENASE (CATALYTIC DOMAIN), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2oxz:A (ASN126) to (TYR262) HUMAN MMP-12 IN COMPLEX WITH TWO PEPTIDES PQG AND IAG | MMP-12, MATRIX METALLOPROTEINASE, HYDROLASE
3f15:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR (S)-N-(2,3-DIHYDROXYPROPYL)-4- METHOXY-N-(2-NITROSO-2-OXOETHYL)BENZENESULFONAMIDE | MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL- BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, ZYMOGEN
1d7x:A (LYS110) to (TYR246) CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR. | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1d8f:A (LYS110) to (TYR246) CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR. | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
1d8f:B (ASP611) to (TYR746) CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR. | MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
3tt4:A (SER105) to (GLY242) HUMAN MMP8 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR | PSEUDO DIPEPTIDES, POTENT INHIBITORS, METZINCIN, ZINC METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2e2d:A (THR130) to (TYR266) FLEXIBILITY AND VARIABILITY OF TIMP BINDING: X-RAY STRUCTURE OF THE COMPLEX BETWEEN COLLAGENASE-3/MMP-13 AND TIMP-2 | MATRIX METALLOPROTEINASE/MMP; COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASES/TIMP; COMPLEX, FLEXIBILITY, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
2usn:A (LYS110) to (TYR246) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-141803 | HYDROLASE, METALLOPROTEASE, FIBROBLAST, COLLAGEN DEGRADATION
1fm1:A (HIS28) to (GLY164) SOLUTION STRUCTURE OF THE CATALYTIC FRAGMENT OF HUMAN COLLAGENASE-3 (MMP-13) COMPLEXED WITH A HYDROXAMIC ACID INHIBITOR | MATRIX METALLOPROTEINASE, HYDROXAMIC ACID, HUMAN COLLAGENASE-3, MMP-13, HYDROLASE
3i7g:A (THR130) to (TYR266) MMP-13 IN COMPLEX WITH A NON ZINC-CHELATING INHIBITOR | PROTEASE, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, SECRETED, ZINC, ZYMOGEN
3i7g:B (THR130) to (TYR266) MMP-13 IN COMPLEX WITH A NON ZINC-CHELATING INHIBITOR | PROTEASE, CALCIUM, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, SECRETED, ZINC, ZYMOGEN
2w0d:A (ARG127) to (TYR262) DOES A FAST NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY- AND X-RAY CRYSTALLOGRAPHY HYBRID APPROACH PROVIDE RELIABLE STRUCTURAL INFORMATION OF LIGAND-PROTEIN COMPLEXES? A CASE STUDY OF METALLOPROTEINASES. | GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, SECRETED, HYDROLASE, HYDROXAMATE, EXTRACELLULAR MATRIX, COPD, MMP-12, ZYMOGEN
2w0d:B (ASN126) to (TYR262) DOES A FAST NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY- AND X-RAY CRYSTALLOGRAPHY HYBRID APPROACH PROVIDE RELIABLE STRUCTURAL INFORMATION OF LIGAND-PROTEIN COMPLEXES? A CASE STUDY OF METALLOPROTEINASES. | GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, SECRETED, HYDROLASE, HYDROXAMATE, EXTRACELLULAR MATRIX, COPD, MMP-12, ZYMOGEN
2w0d:C (ARG127) to (TYR262) DOES A FAST NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY- AND X-RAY CRYSTALLOGRAPHY HYBRID APPROACH PROVIDE RELIABLE STRUCTURAL INFORMATION OF LIGAND-PROTEIN COMPLEXES? A CASE STUDY OF METALLOPROTEINASES. | GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, SECRETED, HYDROLASE, HYDROXAMATE, EXTRACELLULAR MATRIX, COPD, MMP-12, ZYMOGEN
2w0d:D (ARG127) to (TYR262) DOES A FAST NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY- AND X-RAY CRYSTALLOGRAPHY HYBRID APPROACH PROVIDE RELIABLE STRUCTURAL INFORMATION OF LIGAND-PROTEIN COMPLEXES? A CASE STUDY OF METALLOPROTEINASES. | GLYCOPROTEIN, METAL-BINDING, METALLOPROTEASE, SECRETED, HYDROLASE, HYDROXAMATE, EXTRACELLULAR MATRIX, COPD, MMP-12, ZYMOGEN
1hv5:A (ARG127) to (TYR261) CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR | STROMELYSIN-3, INHIBITION, PHOSPHINIC INHIBITOR, HYDROLASE
1hv5:B (ARG127) to (TYR261) CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR | STROMELYSIN-3, INHIBITION, PHOSPHINIC INHIBITOR, HYDROLASE
1hv5:C (ARG127) to (GLY262) CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR | STROMELYSIN-3, INHIBITION, PHOSPHINIC INHIBITOR, HYDROLASE
1hv5:D (VAL126) to (GLY262) CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR | STROMELYSIN-3, INHIBITION, PHOSPHINIC INHIBITOR, HYDROLASE
1hv5:E (ARG127) to (TYR261) CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR | STROMELYSIN-3, INHIBITION, PHOSPHINIC INHIBITOR, HYDROLASE
2wo8:A (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2wo8:B (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2wo8:C (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
2wo8:D (ARG127) to (TYR262) MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID | HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE, METALLOPROTEASE, EXTRACELLULAR MATRIX, ZYMOGEN, PROTEASE, SECRETED
1uea:A (PRO109) to (TYR246) MMP-3/TIMP-1 COMPLEX | PROTEINASE, ZINC-ENDOPEPTIDASE, PROTEINASE INHIBITOR, COMPLEX, MMPS (MATRIX METALLO PROTEINASES) TIMPS (TISSUE INHIBITOR OF METALLO PROTEINASES), METZINCINS, COMPLEX (METALLOPROTEASE/INHIBITOR)
1uea:C (PRO109) to (TYR246) MMP-3/TIMP-1 COMPLEX | PROTEINASE, ZINC-ENDOPEPTIDASE, PROTEINASE INHIBITOR, COMPLEX, MMPS (MATRIX METALLO PROTEINASES) TIMPS (TISSUE INHIBITOR OF METALLO PROTEINASES), METZINCINS, COMPLEX (METALLOPROTEASE/INHIBITOR)
1jao:A (SER105) to (TYR241) COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | METALLOPROTEASE, ZINC-ENDOPEPTIDASE, METZINCINS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1jh1:A (SER105) to (TYR241) CRYSTAL STRUCTURE OF MMP-8 COMPLEXED WITH A 6H-1,3,4- THIADIAZINE DERIVED INHIBITOR | COLLAGENASE, INHIBITOR, THIADIAZINE, HYDROLASE
1jk3:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF HUMAN MMP-12 (MACROPHAGE ELASTASE) AT TRUE ATOMIC RESOLUTION | MATRIX METALLOPROTEINASE, BATIMASTAT, BB94, HYDROXAMIC ACID, MMP12, ELASTASE, COMPLEX (ELASTASE-INHIBITOR), METALLO ELASTASE, HYDROLASE
3wv1:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH 4- (2-((6-FLUORO-2-((3-METHOXYBENZYL)CARBAMOYL)-4-OXO-3,4- DIHYDROQUINAZOLIN-5-YL)OXY)ETHYL)BENZOIC ACID | MMP-13, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wv1:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-13 COMPLEXED WITH 4- (2-((6-FLUORO-2-((3-METHOXYBENZYL)CARBAMOYL)-4-OXO-3,4- DIHYDROQUINAZOLIN-5-YL)OXY)ETHYL)BENZOIC ACID | MMP-13, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2xs4:A (THR59) to (TYR196) STRUCTURE OF KARILYSIN CATALYTIC MMP DOMAIN IN COMPLEX WITH MAGNESIUM | HYDROLASE, BACTERIAL MMP, VIRULENCE FACTOR, METALLOPROTEASE, ZINC- DEPENDENT, PEPTIDASE
2jsd:A (SER134) to (LEU269) SOLUTION STRUCTURE OF MMP20 COMPLEXED WITH NNGH | MMP-NNGH, STRUCTURAL GENOMICS, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, SPINE-2, SPINE2-COMPLEXES, HYDROLASE
5d2b:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF A MUTATED CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH AN HYDROXAMATE ANALOGUE OF RXP470 | METZINCIN, MATRIX METALLO ELASTASE, MMP12, HUMAN, RXP470, MACROPHAGE, HYDROLASE, HYDROXAMATE BASED INHIBITOR
3kry:A (THR130) to (TYR266) CRYSTAL STRUCTURE OF MMP-13 IN COMPLEX WITH SC-78080 | COLLAGENASE, COLLAGENASE-3, MMP-13, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED
3kry:B (THR130) to (TYR266) CRYSTAL STRUCTURE OF MMP-13 IN COMPLEX WITH SC-78080 | COLLAGENASE, COLLAGENASE-3, MMP-13, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED
3kry:C (THR130) to (TYR266) CRYSTAL STRUCTURE OF MMP-13 IN COMPLEX WITH SC-78080 | COLLAGENASE, COLLAGENASE-3, MMP-13, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED
3kry:D (THR130) to (TYR266) CRYSTAL STRUCTURE OF MMP-13 IN COMPLEX WITH SC-78080 | COLLAGENASE, COLLAGENASE-3, MMP-13, COLLAGEN DEGRADATION, DISEASE MUTATION, DISULFIDE BOND, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, PROTEASE, SECRETED
1zvx:A (SER105) to (TYR241) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (R-ENANTIOMER) | STEREOSELECTIVE INHIBITION, PHOSPHONIC INHIBITORS, HYDROLASE, SULFONAMIDE JUNCTION
4dpe:A (LYS110) to (TYR246) STRUCTURE OF MMP3 COMPLEXED WITH A PLATINUM-BASED INHIBITOR. | MATRIX METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dpe:B (LYS110) to (TYR246) STRUCTURE OF MMP3 COMPLEXED WITH A PLATINUM-BASED INHIBITOR. | MATRIX METALLOPROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5i0l:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED ARYLSULFONAMIDE CARBOXYLATE WATER-SOLUBLE INHIBITOR (DC27). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
5i0l:B (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A SELECTIVE SUGAR-CONJUGATED ARYLSULFONAMIDE CARBOXYLATE WATER-SOLUBLE INHIBITOR (DC27). | INHIBITOR, COMPLEX, GLYCOCONJUGATE, METALLOPROTEASE, HYDROLASE
4efs:A (ASN126) to (TYR262) HUMAN MMP12 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR | PSEUDO PEPTIDES, POTENT INHIBITORS, METZINCIN, ZINC PROTEASE, L- GLUTAMATE MOTIF INHIBITORS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gr8:A (ASN126) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470C | POTENT SELECTIVE PHOSPHINIC INHIBITOR, METZINCIN, ZINC PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5l79:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF MMP12 IN COMPLEX WITH RXP470.1 CONJUGATED WITH FLUOROPHORE CY5,5 IN SPACE GROUP P21212. | PROBES FOR OPTICAL IMAGING, MMP-12, METALLOPROTEASE, INFLAMMATION, ANEURYSM, FLUOROPHORE, CY5, 5, CYANINE, HYDROLASE
5lab:A (ARG127) to (TYR262) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR NNGH | HYDROLASE MMP-12, HYDROLASE
966c:A (ARG127) to (TYR260) CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID | MATRIX METALLOPROTEASE