4gso:A (CYS117) to (ASN185) STRUCTURE OF JARARACUSSIN-I | THROMBIN-LIKE ENZYME, HYDROLASE
3rlw:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH MI328 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, HIRUDIN, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rly:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH MI329 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, HIRUDIN, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rm0:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH MI354 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, HIRUDIN, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3rm2:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH MI003 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, HIRUDIN, BLOOD, GLYCOSYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a3b:H (TYR134) to (SER203) COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1 | COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a5g:H (TYR134) to (SER203) HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN | COMPLEX (SERINE PROTEASE-INHIBITOR),HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ank:H (TYR134) to (SER203) ORALLY ACTIVE THROMBIN INHIBITORS IN COMPLEX WITH THROMBIN AND AN EXOSITE DECAPEPTIDE | BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2anm:H (TYR134) to (SER203) TERNARY COMPLEX OF AN ORALLY ACTIVE THROMBIN INHIBITOR WITH HUMAN THROMBIN AND A C-TERMINAL HIRUDIN DERIVED EXO-SIT INHIBITOR | BLOOD CLOTTING
1nfw:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR209685 | HYDROLASE
1nfy:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR200095 | HYDROLASE
1abj:H (TYR134) to (SER203) STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1afe:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP | COMPLEX (SERINE PROTEASE-INHIBITOR), BLOOD COAGULATION, N- CARBOBENZOXY-PRO-ALFA-AZALYS-P-NITROPHENYLESTER, SERINE PROTEINASE INHIBITION, GLYCOSYLATED PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3egk:H (TYR134) to (SER203) KNOBLE INHIBITOR | BLOOD CLOTTING/HYDROLASE INHIBITOR, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1aix:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL | SERINE PROTEINASE, BLOOD COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, BLOOD COAGULATION-HYDROLASE INHIBITOR COMPLEX
1nm6:A (TYR134) to (SER203) THROMBIN IN COMPLEX WITH SELECTIVE MACROCYCLIC INHIBITOR AT 1.8A | THROMBIN INHIBITOR COMPLEX, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1no9:H (TYR134) to (SER203) DESIGN OF WEAKLY BASIC THROMBIN INHIBITORS INCORPORATING NOVEL P1 BINDING FUNCTIONS: MOLECULAR AND X-RAY CRYSTALLOGRAPHIC STUDIES. | COMPLEX (SERINE PROTEASE-INHIBITOR), BLOOD COAGULATION, SERINE PROTEINASE INHIBITION, N,N-DIPHENYLCARBAMOYL-AMINOGUANIDINE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1amh:A (GLN135) to (ASN202) UNCOMPLEXED RAT TRYPSIN MUTANT WITH ASP 189 REPLACED WITH SER (D189S) | SERINE PROTEASE, ACTIVATION DOMAIN, SUBSTRATE SPECIFICITY HYDROLASE
1amh:B (GLN135) to (ASN202) UNCOMPLEXED RAT TRYPSIN MUTANT WITH ASP 189 REPLACED WITH SER (D189S) | SERINE PROTEASE, ACTIVATION DOMAIN, SUBSTRATE SPECIFICITY HYDROLASE
4h4f:A (PRO135) to (GLU204) CRYSTAL STRUCTURE OF HUMAN CHYMOTRYPSIN C (CTRC) BOUND TO INHIBITOR EGLIN C FROM HIRUDO MEDICINALIS | SERINE PROTEASE, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1nt1:A (TYR134) to (SER203) THROMBIN IN COMPLEX WITH SELECTIVE MACROCYCLIC INHIBITOR | THROMBIN INHIBITOR COMPLEX, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
4h6s:B (TYR134) to (LYS202) CRYSTAL STRUCTURE OF THROMBIN MUTANT E14EA/D14LA/E18A/S195A | SERINE PROTEASE, PRETHROMBIN-2, AUTOACTIVATION, HYDROLASE, HYDROLASE- PEPTIDE COMPLEX
4h6t:A (TYR134) to (PRO204) CRYSTAL STRUCTURE OF PRETHROMBIN-2 MUTANT E14EA/D14LA/E18A/S195A | SERINE PROTEASE, PRETHROMBIN-2, AUTOACTIVATION, HYDROLASE
2b5t:B (TYR134) to (PRO204) 2.1 ANGSTROM STRUCTURE OF A NONPRODUCTIVE COMPLEX BETWEEN ANTITHROMBIN, SYNTHETIC HEPARIN MIMETIC SR123781 AND TWO S195A THROMBIN MOLECULES | BLOOD COAGULATION, BLOOD CLOTTING
1aut:C (THR136) to (HIS204) HUMAN ACTIVATED PROTEIN C | SERINE PROTEINASE, PLASMA CALCIUM BINDING, GLYCOPROTEIN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX, BLOOD CLOTTING
1avg:H (PHE134) to (SER203) THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS | BOVINE THROMBIN, THROMBIN INHIBITOR, COMPLEX (BLOOD COAGULATION/INHIBITOR)
3ens:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH METHYL (2Z)-3-[(3- CHLORO-1H-INDOL-7-YL)AMINO]-2-CYANO-3-{[(3S)-2-OXO-1-(2-OXO-2- PYRROLIDIN-1-YLETHYL)AZEPAN-3-YL]AMINO}ACRYLATE | SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF- LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING
3ens:D (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH METHYL (2Z)-3-[(3- CHLORO-1H-INDOL-7-YL)AMINO]-2-CYANO-3-{[(3S)-2-OXO-1-(2-OXO-2- PYRROLIDIN-1-YLETHYL)AZEPAN-3-YL]AMINO}ACRYLATE | SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF- LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING
1nu9:D (TYR134) to (SER203) STAPHYLOCOAGULASE-PRETHROMBIN-2 COMPLEX | THROMBIN NON-PROTEOLYTIC ACTIVATOR, ENDOCARDITIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, PROTEIN BINDING
1awh:B (TYR134) to (PRO204) NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT | PROTEINASE, BLOOD COAGULATION, TRYPSIN LIKE PROTEINASE, COMPLEX (PROTEASE/INHIBITOR)
1awh:D (TYR134) to (SER203) NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT | PROTEINASE, BLOOD COAGULATION, TRYPSIN LIKE PROTEINASE, COMPLEX (PROTEASE/INHIBITOR)
2b7d:H (SER136) to (ARG204) FACTOR VIIA INHIBITORS: CHEMICAL OPTIMIZATION, PRECLINICAL PHARMACOKINETICS, PHARMACODYNAMICS, AND EFFICACY IN A BABOON THROMBOSIS MODEL | SHORT HYDROGEN BOND, BLOOD CLOTTING
1ay6:H (TYR134) to (SER203) THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF | COMPLEX OF SERINE PROTEASE-INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1azz:B (VAL136) to (TYR201) FIDDLER CRAB COLLAGENASE COMPLEXED TO ECOTIN | COMPLEX (SERINE PROTEASE/INHIBITOR), SERINE PROTEASE, INHIBITOR, COMPLEX, PROTEASE-SUBSTRATE INTERACTIONS, COLLAGEN
2p16:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH THE INHIBITOR APIXABAN (BMS- 562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1- PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4- C]PYRIDINE-3-CARBOXAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING
1nzq:H (TYR134) to (SER203) D-PHE-PRO-ARG-TYPE THROMBIN INHIBITOR | THROMBIN, THROMBIN INHIBITOR, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p3f:H (GLY136) to (PHE203) CRYSTAL STRUCTURE OF THE FACTOR XA/NAP5 COMPLEX | FACTOR XA, NEMATODE ANTICOAGULANT PROTEIN, HYDROLASE
2p3u:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN FACTOR XA COMPLEXED WITH 3- CHLORO-N-(4-CHLORO-2-{[(5-CHLOROPYRIDIN-2-YL) AMINO]CARBONYL}-6-METHOXYPHENYL)-4-[(1-METHYL-1H-IMIDAZOL- 2-YL)METHYL]THIOPHENE-2-CARBOXAMIDE {PFIZER 320663} | PROTEIN INHIBITOR COMPLEX, COAGULATION COFACTOR, PROTEASE, BLOOD CLOTTING
2p4v:D (VAL91) to (VAL156) CRYSTAL STRUCTURE OF THE TRANSCRIPT CLEAVAGE FACTOR, GREB AT 2.6A RESOLUTION | TRANSCRIPTION, TRANSCRIPT CLEAVAGE, GRE-FACTORS, CRYSTAL STRUCTURE, RNA POLYMERASE
2bdy:A (TYR170) to (SER243) THROMBIN IN COMPLEX WITH INHIBITOR | THROMBIN, COMPLEX STRUCTURE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4wxi:A (THR134) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR TRANS-N-{(1S)-1-[4-(3-AMINO- 2H-INDAZOL-6-YL)PYRIDIN-2-YL]-2-PHENYLETHYL}-4-(AMINOMETHYL) CYCLOHEXANECARBOXAMIDE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1o0d:H (GLY136) to (SER203) HUMAN THROMBIN COMPLEXED WITH A D-PHE-PRO-ARG-TYPE INHIBITOR AND A C- TERMINAL HIRUDIN DERIVED EXO-SITE INHIBITOR | TERNARY COMPLEX; THROMBIN-ACTIVE-SITE INHIBITOR-EXO-SITE INHIBITOR, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
4hfp:D (TYR134) to (PRO204) STRUCTURE OF THROMBIN MUTANT S195A BOUND TO THE ACTIVE SITE INHIBITOR ARGATROBAN | SERINE PROTEASE, PRETHROMBIN-2, AUTOACTIVATION, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1ba8:B (TYR134) to (SER203) THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bb0:B (TYR134) to (SER203) THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bbr:K (PHE134) to (SER203) THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION | SERINE PROTEASE
2p93:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 5-CHLORO-N-(2-(4-(2- OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING
3f1s:B (ARG257) to (ARG322) CRYSTAL STRUCTURE OF PROTEIN Z COMPLEXED WITH PROTEIN Z-DEPENDENT INHIBITOR | PZ, ZPI, COMPLEX, SERPIN, PROTEASE INHIBITOR, PROTEASE, GLYCOPROTEIN, SECRETED, SERINE PROTEASE INHIBITOR, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, HYDROXYLATION, SERINE PROTEASE HOMOLOG, HYDROLASE INHIBITOR- HYDROLASE COMPLEX
1o2h:A (CYS136) to (SER202) ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE SITE-DIRECTED SERINE PROTEASE INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, INHIBITION MECHANISM, SHIFT OF PKA, TRYPSIN, THROMBIN, UROKINASE, FACTOR XA, HYDROLASE
2bm2:A (PRO135) to (ASN204) HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL- PHENYL)-PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)- METHANONE | SERINE PROTEASE INHIBITOR, GLYCOPROTEIN, HYDROLASE, POLYMORPHISM, PROTEASE, SERINE PROTEASE
2bm2:C (PRO135) to (ASN204) HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL- PHENYL)-PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)- METHANONE | SERINE PROTEASE INHIBITOR, GLYCOPROTEIN, HYDROLASE, POLYMORPHISM, PROTEASE, SERINE PROTEASE
1o34:A (CYS136) to (SER202) ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE SITE-DIRECTED SERINE PROTEASE INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, INHIBITION MECHANISM, SHIFT OF PKA, TRYPSIN, THROMBIN, UROKINASE, FACTOR XA, HYDROLASE
1o3i:A (CYS136) to (SER202) ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE SITE-DIRECTED SERINE PROTEASE INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, INHIBITION MECHANISM, SHIFT OF PKA, TRYPSIN, THROMBIN, UROKINASE, FACTOR XA, HYDROLASE
1o3j:A (CYS136) to (SER202) ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE SITE-DIRECTED SERINE PROTEASE INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, INHIBITION MECHANISM, SHIFT OF PKA, TRYPSIN, THROMBIN, UROKINASE, FACTOR XA, HYDROLASE
1o5d:H (SER136) to (TYR203) DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA) | ALA190 UPA, S1 SITE, SELECTIVITY, CONSERVED WATER DISPLACEMENT HYDROGEN BOND DEFICIT, TRYPSIN, THROMBIN, HEPSIN, FACTOR VIIA, BLOOD CLOTTING, HYDROLASE
1o5g:H (TYR134) to (SER203) DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA) | ALA190 UPA, S1 SITE, SELECTIVITY, CONSERVED WATER DISPLACEMENT HYDROGEN BOND DEFICIT, TRYPSIN, THROMBIN, HEPSIN, FACTOR VIIA, BLOOD CLOTTING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, BLOOD CLOTTING,HYDROLASE-INHIBITOR COMPLEX
1bml:B (GLU679) to (LYS750) COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE | HUMAN PLASMIN, STREPTOKINASE, BLOOD CLOTTING
1bmm:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-4-[(AMINOIMINOMETHYL) AMINO]-N-[[1-[3-HYDROXY-2-[(2-NAPHTHALENYLSULFONYL)AMINO]-1- OXOPROPYL]-2-PYRROLIDINYL] METHYL]BUTANAMIDE (BMS-186282) | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bmn:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-1-(AMINOIMINOMETHYL)- N-[[1-[N-[(2-NAPHTHALENYLSULFONYL)-L-SERYL]-PYRROLIDINYL]METHYL]-3- PIPERIDENECARBOXAMIDE (BMS-189090) | HYDROLASE, COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bok:A (GLY136) to (PHE203) FACTOR XA - CATION | SERINE PROTEASE, COAGULATION FACTOR, CATION, INHIBITOR, EGF- LIKE DOMAIN, HYDROLASE, PLASMA, PROTEASE
2boh:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND "1" | HYDROLASE/INHIBITOR, COMPLEX (HYDROLASE/INHIBITOR), PROTEIN-INHIBITOR COMPLEX, BLOOD COAGULATION FACTOR, SERINE PROTEINASE, RATIONAL DRUG DESIGN, CALCIUM-BINDING, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, PLASMA, POLYMORPHISM, PROTEASE, REPEAT, SERINE PROTEASE, VITAMIN K, ZYMOGEN, HYDROLASE-INHIBITOR COMPLEX
3s69:A (VAL132) to (CYS201) CRYSTAL STRUCTURE OF SAXTHROMBIN | BETA-BARREL, SERINE ENZYMES, FIBRINOGEN BINDING, GLYCOSYLATION, HYDROLASE
2bq7:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 43 | BLOOD COAGULATION, BLOOD COAGULATION FACTOR, CALCIUM- BINDING, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, PLASMA, POLYMORPHISM, PROTEIN INHIBITOR COMPLEX, SERINE PROTEINASE, SERINE PROTEASE, VITAMIN K, ZYMOGEN
3s7k:B (TYR134) to (SER203) STRUCTURE OF THROMBIN MUTANT Y225P IN THE E FORM | SERINE PROTEASE, HYDROLASE
4x6m:A (THR134) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR 1-{(1S)-1-[4-(3-AMINO-1H- INDAZOL-6-YL)-5-CHLORO-1H-IMIDAZOL-2-YL]-2-PHENYLETHYL}-3-[2- (AMINOMETHYL)-5-CHLOROBENZYL]UREA | SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bth:K (TYR134) to (SER203) STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR | THROMBIN INHIBITOR, SERINE PROTEINASE KUNITZ-LIKE INHIBITOR, (SERINE PROTEASE/INHIBITOR), COMPLEX (SERINE PROTEASE/INHIBITOR) COMPLEX
3s9c:A (CYS136) to (CYS201) RUSSELL'S VIPER VENOM SERINE PROTEINASE, RVV-V IN COMPLEX WITH THE FRAGMENT (RESIDUES 1533-1546) OF HUMAN FACTOR V | SERINE PROTEINASE, DOUBLE SIX-STRANDED BETA-BARRELS, HYDROLASE, GLYCOSYLATION
4x8v:H (SER136) to (ARG204) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (METHYL {3-[(2R)-1-{(2R)-2- (3,4-DIMETHOXYPHENYL)-2-[(1-OXO-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL) AMINO]ACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL) PHENYL}CARBAMATE) | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING
4x8s:H (SER136) to (ARG204) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 4-BROMO-2-METHOXYPHENOL | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING
4x8u:H (SER136) to (ARG204) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 5-CHLORO-1H-INDOLE-2- CARBOXYLIC ACID | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4htc:H (TYR134) to (SER203) THE REFINED STRUCTURE OF THE HIRUDIN-THROMBIN COMPLEX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE
2pgb:B (TYR134) to (SER203) INHIBITOR-FREE HUMAN THROMBIN MUTANT C191A-C220A | SERINE PROTEASE, HYDROLASE
2phb:A (GLY136) to (LYS204) AN ORALLY EFFICACIOUS FACTOR XA INHIBITOR | FXA COAGULATION FACTOR INHIBITOR, BLOOD CLOTTING
2bvs:H (TYR134) to (SER203) HUMAN THROMBIN COMPLEXED WITH FRAGMENT-BASED SMALL MOLECULES OCCUPYING THE S1 POCKET | SERINE PROTEASE, COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c1v:H (TYR134) to (SER209) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE/INHIBITOR, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bxu:H (GLY136) to (SER203) DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4xde:A (LEU480) to (GLU551) COAGULATION FACTOR XII PROTEASE DOMAIN CRYSTAL STRUCTURE | FACTOR XII, CATALYTIC DOMAIN, ZYMOGENS, HYDROLASE, BLOOD CLOTTING
4xe4:A (THR479) to (GLU551) COAGULATION FACTOR XII PROTEASE DOMAIN CRYSTAL STRUCTURE | FACTOR XII, ZYMOGENS, CATALYTIC DOMAIN, ACTIVE SITE, BLOOD CLOTTING
1c4v:2 (TYR134) to (LYS202) SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES. | COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c5l:H (TYR134) to (SER203) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB- MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1c5n:H (TYR134) to (SER203) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB- MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | S1 SITE INHIBITOR, UROKINASE, TRYPSIN, BLOOD CLOTTING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1c5o:H (TYR134) to (SER203) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB- MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
3sha:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH UBTHR97 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3shc:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH UBTHR101 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1c9p:A (CYS136) to (ASN202) COMPLEX OF BDELLASTASIN WITH PORCINE TRYPSIN | COMPLEX (HYDROLASE-INHIBITOR), HYDROLASE, INHIBITOR, ANTISTASIN, PLASMIN, ISOASPARTATE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c9t:B (CYS136) to (SER202) COMPLEX OF BDELLASTASIN WITH BOVINE TRYPSIN | COMPLEX (HYDROLASE/INHIBITOR), HYDROLASE, INHIBITOR, ANTISTASIN, PLASMIN, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1c9t:C (CYS136) to (SER202) COMPLEX OF BDELLASTASIN WITH BOVINE TRYPSIN | COMPLEX (HYDROLASE/INHIBITOR), HYDROLASE, INHIBITOR, ANTISTASIN, PLASMIN, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1c9t:E (CYS136) to (SER202) COMPLEX OF BDELLASTASIN WITH BOVINE TRYPSIN | COMPLEX (HYDROLASE/INHIBITOR), HYDROLASE, INHIBITOR, ANTISTASIN, PLASMIN, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1ca8:B (TYR134) to (SER203) THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3si3:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH UBTHR103 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3si4:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH UBTHR104 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pux:B (TYR134) to (PRO204) CRYSTAL STRUCTURE OF MURINE THROMBIN IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF MURINE PAR3 | SERINE PROTEASE, HYDROLASE
2pv9:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF MURINE THROMBIN IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF MURINE PAR4 | SERINE PROTEASE, HYDROLASE
1cgi:E (THR135) to (LYS202) THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE) | SERINE PROTEASE/INHIBITOR COMPLEX
1cgj:E (CYS136) to (ASN204) THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE) | SERINE PROTEASE/INHIBITOR COMPLEX
1chg:A (THR134) to (LYS202) CHYMOTRYPSINOGEN,2.5 ANGSTROMS CRYSTAL STRUCTURE, COMPARISON WITH ALPHA-CHYMOTRYPSIN,AND IMPLICATIONS FOR ZYMOGEN ACTIVATION | HYDROLASE ZYMOGEN (SERINE PROTEINASE)
1op8:B (CYS136) to (CYS201) CRYSTAL STRUCTURE OF HUMAN GRANZYME A | GRANZYME A, SERINE PROTEINASE, APOPTOSIS, HYDROLASE
3sos:A (ASP513) to (ASN584) BENZOTHIAZINONE INHIBITOR IN COMPLEX WITH FXIA | HYDROLASE, SERINE PROTEASE, COAGULATION FACTOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2q1j:A (GLY136) to (LYS204) THE DISCOVERY OF GLYCINE AND RELATED AMINO ACID-BASED FACTOR XA INHIBITORS | COAGULATION FXA, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, POLYMORPHISM, PROTEASE, SERINE PROTEASE, ZYMOGEN
1owd:A (CYS134) to (SER204) SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE | PLASMINOGEN ACTIVATION, HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, KRINGLE, EGF-LIKE DOMAIN
1owe:A (CYS147) to (SER218) SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE | PLASMINOGEN ACTIVATION, HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, KRINGLE, EGF-LIKE DOMAIN
1owi:A (THR132) to (SER204) SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE | PLASMINOGEN ACTIVATION, HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, KRINGLE, EGF-LIKE DOMAIN
1oxg:A (CYS136) to (LYS202) CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN ORGANIC SOLVENT TREATED BOVINE ALPHA-CHYMOTRYPSIN AND ITS AUTOCATALYTICALLY PRODUCED HIGHLY POTENT 14-RESIDUE PEPTIDE AT 2.2 RESOLUTION | AUTOCATALYSIS, ORGANIC SOLVENT TREATMENT, INHIBITION, HYDROLASE
1oyt:H (TYR134) to (SER203) COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sv2:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH UBTHR105 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, HIRUDIN, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sw2:B (GLY136) to (PHE203) X-RAY CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH 6-CHLORO-N-((3S)- 2-OXO-1-(2-OXO-2-((5S)-8-OXO-5,6-DIHYDRO-1H-1,5-METHANOPYRIDO[1,2- A][1,5]DIAZOCIN-3(2H,4H,8H)-YL)ETHYL)PIPERIDIN-3-YL)NAPHTHALENE-2- SULFONAMIDE | SERINE PROTEASE, EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, HYDROLASE, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1p2m:A (CYS136) to (LYS202) STRUCTURAL CONSEQUENCES OF ACCOMMODATION OF FOUR NON- COGNATE AMINO-ACID RESIDUES IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN | TRYPSIN; CHYMOTRYPSIN; SERINE PROTEINASE; BOVINE PANCREATIC TRYPSIN INHIBITOR; PROTEIN-PROTEIN INTERACTION; NON-COGNATE BINDING; S1 POCKET; PRIMARY SPECIFICITY; CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1p2n:A (THR135) to (LYS202) STRUCTURAL CONSEQUENCES OF ACCOMMODATION OF FOUR NON- COGNATE AMINO-ACID RESIDUES IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN | TRYPSIN; CHYMOTRYPSIN; SERINE PROTEINASE; BOVINE PANCREATIC TRYPSIN INHIBITOR; PROTEIN-PROTEIN INTERACTION; NON-COGNATE BINDING; S1 POCKET; PRIMARY SPECIFICITY; CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1d9i:A (GLY136) to (SER203) STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTOPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1 | GLOBULAR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1p8v:C (TYR134) to (SER213) CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A | PLATELET GLYCOPROTEIN RECEPTOR, LEUCINE RICH REPEAT DOMAIN, MEMBRANE PROTEIN-HYDROLASE COMPLEX
1ddj:B (GLU679) to (LYS750) CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN | PLASMINOGEN, CATALYTIC DOMAIN, BLOOD CLOTTING
1ddj:D (GLU679) to (LYS750) CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN | PLASMINOGEN, CATALYTIC DOMAIN, BLOOD CLOTTING
1de7:H (TYR134) to (SER203) INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX | ENZYME-SUBSTRATE COMPLEX, ALPHA-THROMBIN, FACTOR XIII ACTIVATION PEPTIDE, HYDROLASE/PEPTIDE, BLOOD CLOTTING, HYDROLASE-HYDROLASE SUBSTRATE COMPLEX
1de7:K (TYR134) to (SER203) INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX | ENZYME-SUBSTRATE COMPLEX, ALPHA-THROMBIN, FACTOR XIII ACTIVATION PEPTIDE, HYDROLASE/PEPTIDE, BLOOD CLOTTING, HYDROLASE-HYDROLASE SUBSTRATE COMPLEX
1dic:A (CYS136) to (GLY202) STRUCTURE OF 3,4-DICHLOROISOCOUMARIN-INHIBITED FACTOR D | SERINE PROTEASE, COMPLEMENT, FACTOR D, HYDROLASE
1pfx:C (GLY136) to (GLU204) PORCINE FACTOR IXA | HEMOPHILIA/EGF, BLOOD COAGULATION, PLASMA, SERINE PROTEASE, CALCIUM- BINDING, HYDROLASE, GLYCOPROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1dit:H (TYR134) to (SER203) COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN | HYDROLASE, BLOOD COAGULATION, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3t2n:A (LYS289) to (SER362) HUMAN HEPSIN PROTEASE IN COMPLEX WITH THE FAB FRAGMENT OF AN INHIBITORY ANTIBODY | TYPE II TRANSMEMBRANE SERINE PROTEASE, SRCR DOMAIN, SUBSTRATES INCLUDE PRO-HEPSIN, PRO-HGF, LAMININ-332, TRANSMEMBRANE, HYDROLASE
3t2n:B (LYS289) to (SER362) HUMAN HEPSIN PROTEASE IN COMPLEX WITH THE FAB FRAGMENT OF AN INHIBITORY ANTIBODY | TYPE II TRANSMEMBRANE SERINE PROTEASE, SRCR DOMAIN, SUBSTRATES INCLUDE PRO-HEPSIN, PRO-HGF, LAMININ-332, TRANSMEMBRANE, HYDROLASE
1dle:A (LYS135) to (ARG204) FACTOR B SERINE PROTEASE DOMAIN | SERINE PROTEASE, COMPLEMENT SYSTEM, FACTOR B, PROTEIN- PROTEIN INTERACTION, ACTIVATION MECHANISM, BETA-BARREL FOLD, , HYDROLASE
1dle:B (LYS135) to (ARG204) FACTOR B SERINE PROTEASE DOMAIN | SERINE PROTEASE, COMPLEMENT SYSTEM, FACTOR B, PROTEIN- PROTEIN INTERACTION, ACTIVATION MECHANISM, BETA-BARREL FOLD, , HYDROLASE
2qn5:T (CYS134) to (SER202) CRYSTAL STRUCTURE AND FUNCTIONAL STUDY OF THE BOWMAN-BIRK INHIBITOR FROM RICE BRAN IN COMPLEX WITH BOVINE TRYPSIN | RBTI, BOWMAN-BIRK INHIBITOR, MONOCOTYLEDONOUS PLANT, REACTIVE-SITE LOOP, PROTEASE-INHIBITOR, PLANT-PEST SYSTEMS, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, CALCIUM, DIGESTION, HYDROLASE, METAL-BINDING, SECRETED, ZYMOGEN, HYDROLASE INHIBITOR/HYDROLASE COMPLEX, HETERO-DIMER
1doj:A (TYR134) to (SER203) CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN*RWJ-51438 COMPLEX AT 1.7 A | THROMBIN, SERINE PROTEASE, ENZYME INHIBITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1dst:A (CYS136) to (GLY202) MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY | COMPLEMENT ACTIVATING ENZYME, HYDROLASE, SERINE PROTEASE, FACTOR D, HYDROLASE (SERINE PROTEASE)
1dsu:A (CYS136) to (GLY202) HUMAN FACTOR D, COMPLEMENT ACTIVATING ENZYME | COMPLEMENT ACTIVATING ENZYME, HYDROLASE, SERINE PROTEASE, HYDROLASE (SERINE PROTEASE)
3t62:A (THR135) to (ASN204) CRYSTAL STRUCTURE OF RECOMBINANT KUNITZ TYPE SERINE PROTEASE INHIBITOR-1 FROM THE CARIBBEAN SEA ANEMONE STICHODACTYLA HELIANTHUS IN COMPLEX WITH BOVINE CHYMOTRYPSIN | CHYMOTRYPSIN-INHIBITOR COMPLEX, KUNITZ-TYPE SERINE PROTEASE INHIBITOR, SECRETED, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3t62:B (THR135) to (LYS202) CRYSTAL STRUCTURE OF RECOMBINANT KUNITZ TYPE SERINE PROTEASE INHIBITOR-1 FROM THE CARIBBEAN SEA ANEMONE STICHODACTYLA HELIANTHUS IN COMPLEX WITH BOVINE CHYMOTRYPSIN | CHYMOTRYPSIN-INHIBITOR COMPLEX, KUNITZ-TYPE SERINE PROTEASE INHIBITOR, SECRETED, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3t62:C (CYS136) to (LYS202) CRYSTAL STRUCTURE OF RECOMBINANT KUNITZ TYPE SERINE PROTEASE INHIBITOR-1 FROM THE CARIBBEAN SEA ANEMONE STICHODACTYLA HELIANTHUS IN COMPLEX WITH BOVINE CHYMOTRYPSIN | CHYMOTRYPSIN-INHIBITOR COMPLEX, KUNITZ-TYPE SERINE PROTEASE INHIBITOR, SECRETED, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gis:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF NA-FREE THROMBIN IN COMPLEX WITH THROMBOMODULIN | PROTEIN-PROTEIN COMPLEX, COAGULATION, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, EGF-LIKE DOMAIN, HYDROXYLATION, MEMBRANE, RECEPTOR, THROMBOPHILIA, TRANSMEMBRANE, BLOOD CLOTTING
3gis:D (TYR134) to (SER203) CRYSTAL STRUCTURE OF NA-FREE THROMBIN IN COMPLEX WITH THROMBOMODULIN | PROTEIN-PROTEIN COMPLEX, COAGULATION, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, EGF-LIKE DOMAIN, HYDROXYLATION, MEMBRANE, RECEPTOR, THROMBOPHILIA, TRANSMEMBRANE, BLOOD CLOTTING
3gis:F (TYR134) to (SER203) CRYSTAL STRUCTURE OF NA-FREE THROMBIN IN COMPLEX WITH THROMBOMODULIN | PROTEIN-PROTEIN COMPLEX, COAGULATION, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, EGF-LIKE DOMAIN, HYDROXYLATION, MEMBRANE, RECEPTOR, THROMBOPHILIA, TRANSMEMBRANE, BLOOD CLOTTING
1ppz:A (SER131) to (ASP201) TRYPSIN COMPLEXES AT ATOMIC AND ULTRA-HIGH RESOLUTION | TRYPSIN, SERINE PROTEASE, ATOMIC AND ULTRA-HIGH RESOLUTION, COMPLEX, DFP, HYDROLASE
1dwb:H (TYR134) to (SER203) CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1dwc:H (TYR134) to (PRO204) CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS | SERINE PROTEINASE, HYDROLASE-HYROLASE INHIBITOR COMPLEX
1dwd:H (TYR134) to (SER203) CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS | SERINE PROTEINASE, HYDROLASE-HYROLASE INHIBITOR COMPLEX
1pqa:A (SER131) to (ASP201) TRYPSIN WITH PMSF AT ATOMIC RESOLUTION | TRYPSIN, ATOMIC RESOLUTION, PMSF, CATALYSIS, HYDROLASE
2d26:C (PRO135) to (LEU202) ACTIVE SITE DISTORTION IS SUFFICIENT FOR PROTEINASE INHIBIT SECOND CRYSTAL STRUCTURE OF COVALENT SERPIN-PROTEINASE COMPLEX | SERPINE PROTEINASE, SERPIN, COVALENT SERPIN-PROTEINASE COMP PROTEIN-PROTEIN INTERACTIONS, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
2qxg:A (THR135) to (ARG202) CRYSTAL STRUCTURE OF HUMAN KALLIKREIN 7 IN COMPLEX WITH ALA- ALA-PHE-CHLOROMETHYLKETONE | DIMER, 37 LOOP, ACTIVE SITE INHIBITOR, CHLOROMETHYL KETONE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN
2qxg:B (THR135) to (ARG202) CRYSTAL STRUCTURE OF HUMAN KALLIKREIN 7 IN COMPLEX WITH ALA- ALA-PHE-CHLOROMETHYLKETONE | DIMER, 37 LOOP, ACTIVE SITE INHIBITOR, CHLOROMETHYL KETONE, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN
2r0k:A (LYS135) to (LYS203) PROTEASE DOMAIN OF HGFA WITH INHIBITOR FAB58 | SERINE PROTEASE, ANTIBODY, INHIBITOR, EGF-LIKE DOMAIN, GLYCOPROTEIN, HYDROLASE, KRINGLE, SECRETED, ZYMOGEN, IMMUNE SYSTEM
4y6d:A (GLY136) to (PHE203) FACTOR XA COMPLEX WITH GTC000101 | HYDROLASE, INHIBITOR
1pyt:D (PRO835) to (GLN902) TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C | TERNARY COMPLEX (ZYMOGEN), SERINE PROTEINASE, C-TERMINAL PEPTIDASE
4y76:A (GLY136) to (PHE203) FACTOR XA COMPLEX WITH GTC000401 | HYDROLASE, INHIBITOR
4y79:A (GLY136) to (PHE203) FACTOR XA COMPLEX WITH GTC000406 | HYDROLASE, INHIBITOR
4y7a:A (GLY136) to (PHE203) FACTOR XA COMPLEX WITH GTC000422 | HYDROLASE, INHIBITOR
4y7b:A (GLY136) to (LYS204) FACTOR XA COMPLEX WITH GTC000441 | HYDROLASE, INHIBITOR
3th2:H (SER136) to (ARG204) MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+ | HYDROLASE, BLOOD CLOTTING, SERINE PROTEASE, BLOOD COAGULATION, SOLUBLE TISSUE FACTOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3th4:H (SER136) to (ARG204) MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+ | HYDROLASE, SERINE PROTEASE, BLOOD CLOTTING, SOLUBLE TISSUE FACTOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1eai:B (PRO135) to (CYS201) COMPLEX OF ASCARIS CHYMOTRPSIN/ELASTASE INHIBITOR WITH PORCINE ELASTASE | SERINE PROTEINASE, ELASTASE, ASCARIS SUMM, PROTEIN INHIBITOR
1eaw:A (ILE136) to (ALA204) CRYSTAL STRUCTURE OF THE MTSP1 (MATRIPTASE)-BPTI (APROTININ) COMPLEX | HYDROLASE/INHIBITOR, COMPLEX (SERINE PROTEASE INHIBITOR), SERINE PROTEINASE, MATRIX DEGRADATION, INHIBITOR, GLYCOPROTE HYDROLASE
4y8y:A (CYS136) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR METHYL (4-{4-CHLORO-2-[(1S)- 1-({(2E)-3-[5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL]PROP-2-ENOYL}AMINO)- 3-(MORPHOLIN-4-YL)-3-OXOPROPYL]-1H-IMIDAZOL-5-YL}PHENYL)CARBAMATE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tk5:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH D102-4380 | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD, COAGULATION FACTOR, CALCIUM-BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jew:A (ARG35) to (GLU84) N-ACETYLORNITHINE AMINOTRANSFERASE FROM S. TYPHIMURIUM COMPLEXED WITH L-CANALINE | PLP DEPENDENT FOLD TYPE I SUB CLASS II AMINOTRANSFERASE, TRANSFERASE
4jex:B (ARG35) to (GLU84) Y21K MUTANT OF N-ACETYLORNITHINE AMINOTRANSFERASE COMPLEXED WITH L- CANALINE | PLP DEPENDENT FOLD TYPE I SUB CLASS II AMINOTRANSFERASE, TRANSFERASE
3gyl:B (CYS136) to (GLU204) STRUCTURE OF PROSTASIN AT 1.3 ANGSTROMS RESOLUTION IN COMPLEX WITH A CALCIUM ION. | PROSTASIN, ENAC, ZYMOGEN, DIVALENT CATION, CHANNEL ACTIVATING, CELL MEMBRANE, DISULFIDE BOND, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PROTEASE, SECRETED, SERINE PROTEASE, TRANSMEMBRANE
1eoj:A (TYR134) to (SER203) DESIGN OF P1' AND P3' RESIDUES OF TRIVALENT THROMBIN INHIBITORS AND THEIR CRYSTAL STRUCTURES | THROMBIN INHIBITORS, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1qj5:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, BIOTIN BIOSYNTHESIS
1qj5:B (GLU36) to (ALA86) CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, BIOTIN BIOSYNTHESIS
3tu7:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN COMPLEXED WITH N-(METHYLSULFONYL)-D-PHENYLALANYL- N-((1-CARBAMIMIDOYL-4-PIPERIDINYL)METHYL)-L-PROLINAMIDE (BMS-189664) | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jni:U (CYS136) to (SER202) CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH ITS INHIBITOR 4- BROMOBENZYLAMINE AT PH 4.6 | UPA, HALOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2thf:B (TYR134) to (SER203) STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG- CHLOROMETHYLKETONE | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ezu:C (GLN535) to (ASN602) ECOTIN Y69F, D70P BOUND TO D102N TRYPSIN | MACROMOLECULAR COMPLEX, PROTEASE INHIBITOR, PROTEIN-PROTEIN INTERACTIONS, HYDROLASE/INHIBITOR COMPLEX
2tpi:Z (CYS136) to (SER202) ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY | COMPLEX (PROTEINASE/INHIBITOR), HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1f0r:A (GLY136) to (LYS204) CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
1f0s:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208707 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2uuj:B (TYR134) to (SER203) THROMBIN-HIRUGEN-GW473178 TERNARY COMPLEX AT 1.32A RESOLUTION | BLOOD CLOTTING, GLYCOPROTEIN, SERINE PROTEASE, SERINE PROTEASE INHIBITOR, HIRUGEN, ZYMOGEN, THROMBIN, PROTEASE, SULFATION, HIGH RESOLUTION, SERINE PROTEINASE, BLOOD COAGULATION, PROTEASE INHIBITOR, NON-COVALENT ACTIVE SITE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1qrz:D (GLU679) to (LYS750) CATALYTIC DOMAIN OF PLASMINOGEN | MICROPLASMINOGEN, SERINE PROTEASE, ZYMOGEN, CHYMOTRYPSIN FAMILY, HYDROLASE
1qur:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE-BASED SYNTHETIC INHIBITOR | TRYPSIN LIKE SERINE PROTEASE, BLOOD COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3hat:H (TYR134) to (SER203) ACTIVE SITE MIMETIC INHIBITION OF THROMBIN | COMPLEX (SERINE PROTEASE-INHIBITOR), COMPLEX (SERINE PROTEASE- INHIBITOR) COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u69:H (TYR454) to (SER533) UNLIGANDED WILD-TYPE HUMAN THROMBIN | HYDROLASE
2uwp:A (GLY136) to (PHE203) FACTOR XA INHIBITOR COMPLEX | TARGET HOPPING, SERINE PROTEASE, EGF-LIKE DOMAIN, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE, BLOOD COAGULATION, GAMMA- CARBOXYGLUTAMIC ACID, CLEAVAGE ON PAIR OF BASIC RESIDUES
4jyv:H (SER136) to (TYR203) STRUCTURE OF FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (2R)-2-[3- ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-2-(ISOQUINOLIN-6-YLAMINO)-N-[(3- SULFAMOYLPHENYL)SULFONYL]ETHANAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3u8r:H (TYR454) to (SER533) HUMAN THROMBIN COMPLEXED WITH D-PHE-PRO-D-ARG-ILE | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u8t:H (TYR454) to (SER533) HUMAN THROMBIN COMPLEXED WITH D-PHE-PRO-D-ARG-CYS | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jze:H (SER136) to (ARG204) STRUCTURE OF FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 2-{2-[(1- AMINOISOQUINOLIN-6-YL)CARBAMOYL]-6-METHOXYPYRIDIN-3-YL}-5-{[(2S)-1- HYDROXY-3,3-DIMETHYLBUTAN-2-YL]CARBAMOYL}BENZOIC ACID | GLYCOPROTEIN, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u98:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH MI001 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, HIRUDIN, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ym9:A (PRO135) to (LEU202) CRYSTAL STRUCTURE OF PORCINE PANCREATIC ELASTASE (PPE) IN COMPLEX WITH THE NOVEL INHIBITOR JM102 | PORCINE PANCREATIC ELASTASE, INHIBITOR, HYDROLASE
1fjs:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA | PROTEIN INHIBITOR COMPLEX, COAGULATION COFACTOR, PROTEASE, BLOOD CLOTTING
4k3j:A (SER611) to (GLN681) CRYSTAL STRUCTURE OF ONARTUZUMAB FAB IN COMPLEX WITH MET AND HGF-BETA | ANTIBODY, GLYCOSYLATION, TRANSFERASE-IMMUNE SYSTEM-GROWTH FACTOR COMPLEX
3hkj:B (TYR134) to (CYS191) CRYSTAL STRUCTURE OF HUMAN THROMBIN MUTANT W215A/E217A IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF HUMAN PAR1 | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, ZYMOGEN, CELL MEMBRANE, G-PROTEIN COUPLED RECEPTOR, MEMBRANE, PHOSPHOPROTEIN, RECEPTOR, TRANSDUCER, TRANSMEMBRANE
1rd3:D (TYR134) to (PRO204) 2.5A STRUCTURE OF ANTICOAGULANT THROMBIN VARIANT E217K | HYDROLASE
1fq3:B (CYS136) to (ASN202) CRYSTAL STRUCTURE OF HUMAN GRANZYME B | CHYMOTRYPSIN-LIKE SERINE PROTEINASE, HYDROLASE
4yzu:A (GLY136) to (VAL203) RAPID DEVELOPMENT OF TWO FACTOR IXA INHIBITORS FROM HIT TO LEAD | SERINE PROTEINASE, BLOOD COAGULATION, COAGULATION FACTOR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2f83:A (ASP495) to (ASN566) CRYSTAL STRUCTURE AT 2.9 ANGSTROMS RESOLUTION OF HUMAN PLASMA COAGULATION FACTOR XI ZYMOGEN | PROTEASE, APPLE DOMAIN, HYDROLASE
1rrk:A (LYS604) to (ARG683) CRYSTAL STRUCTURE ANALYSIS OF THE BB SEGMENT OF FACTOR B | FACTOR B, BB, HYDROLASE
4z0k:A (GLY136) to (GLU204) RAPID DEVELOPMENT OF TWO FACTOR IXA INHIBITORS FROM HIT TO LEAD | SERINE PROTEINASE, BLOOD COAGULATION, COAGULATION FACTOR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2f9b:H (SER136) to (ARG204) DISCOVERY OF NOVEL HETEROCYCLIC FACTOR VIIA INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, ACTIVE SITE-DIRECTED INHIBITOR, HYDROLASE/BLOOD CLOTTING COMPLEX
2f9n:A (PRO135) to (ASN204) CRYSTAL STRUCTURE OF THE RECOMBINANT HUMAN ALPHA I TRYPTASE MUTANT K192Q/D216G IN COMPLEX WITH LEUPEPTIN | SERINE PROTEINASE, LEUPEPTIN, TRYPSIN-LIKE, DIFUCOSYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f9n:C (PRO135) to (ASN204) CRYSTAL STRUCTURE OF THE RECOMBINANT HUMAN ALPHA I TRYPTASE MUTANT K192Q/D216G IN COMPLEX WITH LEUPEPTIN | SERINE PROTEINASE, LEUPEPTIN, TRYPSIN-LIKE, DIFUCOSYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f9o:D (PRO135) to (ASN204) CRYSTAL STRUCTURE OF THE RECOMBINANT HUMAN ALPHA I TRYPTASE MUTANT D216G | SERINE PROTEINASE, TRYPSIN-LIKE, DIFUCOSYLATION, HYDROLASE
1rtk:A (LYS604) to (ARG683) CRYSTAL STRUCTURE ANALYSIS OF THE BB SEGMENT OF FACTOR B COMPLEXED WITH 4-GUANIDINOBENZOIC ACID | FACTOR B, BB, FACTOR BB-INHIBITOR COMPLEX, HORMONE/GROWTH FACTOR COMPLEX
1g2l:A (GLY140) to (PHE208) FACTOR XA INHIBITOR COMPLEX | BLOOD COAGULATION, FACTOR XA, INHIBITOR COMPLEXES, SERINE PROTEINASE, BLOOD COAGULATION CASCADE, HYDROLASE
1g32:B (TYR134) to (SER203) THROMBIN INHIBITOR COMPLEX | BLOOD COAGULATION; FACTOR XA; INHIBITOR COMPLEXES, SERINE PROTEINASE, BLOOD COAGULATION CASCADE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1g37:A (TYR134) to (SER203) CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE | PROTEASE, THROMBIN, INHIBITOR, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4kga:A (CYS136) to (ASN202) CRYSTAL STRUCTURE OF KALLIKREIN-RELATED PEPTIDASE 4 | KLK4, KALLIKREIN-4, SERINE PROTEASE, PROTEASE, HYDROLASE
2fes:H (TYR134) to (SER203) ORALLY ACTIVE THROMBIN INHIBITORS | THROMBIN INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1rxp:A (CYS136) to (SER202) STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT- BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO- PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID | TRYPTASE INHIBITOR; SERINE PROTEASE; AZETIDINONE, HYDROLASE
2vh6:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH BIARYL P4 MOTIFS | SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, GAMMA-CARBOXYGLUTAMIC ACID, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE, CLEAVAGE ON PAIR OF BASIC RESIDUES
1s06:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE R253K MUTANT OF 7,8- DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER
1s08:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE D147N MUTANT OF 7,8- DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER
1s0a:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE Y17F MUTANT OF 7,8- DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER
1s0a:B (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE Y17F MUTANT OF 7,8- DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER
2viq:A (CYS136) to (SER202) FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PLASMINOGEN ACTIVATION, EGF-LIKE DOMAIN, BLOOD COAGULATION, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, FIBRINOLYSIS, KRINGLE, ZYMOGEN, SECRETED, PROTEASE, HYDROLASE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, PHARMACEUTICAL, SERINE PROTEASE, PHOSPHORYLATION
4kkd:A (GLY588) to (PHE671) THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDING LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURAL BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE 3MC SYNDROME | PROTEASE, CHYMOTRYPSIN FOLD, SECRETED, HYDROLASE
1gcd:A (THR135) to (LYS203) REFINED CRYSTAL STRUCTURE OF "AGED" AND "NON-AGED" ORGANOPHOSPHORYL CONJUGATES OF GAMMA-CHYMOTRYPSIN | HYDROLASE(SERINE PROTEINASE)
3uwj:H (TYR134) to (SER203) HUMAN THROMBIN IN COMPLEX WITH MI353 | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, HIRUDIN, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3hs0:I (LYS604) to (ARG683) COBRA VENOM FACTOR (CVF) IN COMPLEX WITH HUMAN FACTOR B | SERINE PROTEASE, GLYCOSILATED, MULTI-DOMAIN, COMPLEMENT SYSTEM, CONVERTASE, COMPLEMENT ALTERNATE PATHWAY, COMPLEMENT PATHWAY, DISULFIDE BOND, GLYCOPROTEIN, IMMUNE RESPONSE, INFLAMMATORY RESPONSE, INNATE IMMUNITY, SECRETED, THIOESTER BOND, CLEAVAGE ON PAIR OF BASIC RESIDUES, GLYCATION, HYDROLASE, PROTEASE, SUSHI, ZYMOGEN, IMMUNE SYSTEM
2fs8:A (PRO135) to (LYS202) HUMAN BETA-TRYPTASE II WITH INHIBITOR CRA-29382 | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
2fs9:D (MET134) to (VAL203) HUMAN BETA TRYPTASE II WITH INHIBITOR CRA-28427 | SERINE PROTEASE, SERINE PROTEINASE, 28427, HYDROLASE
1ghx:H (TYR134) to (SER203) A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE | THREE-CENTERED, VERY SHORT HYDROGEN BOND, OXYANION HOLE WATER, SHIFT OF PKA OF HIS57, STRUCTURE-BASED DRUG DESIGN, SPECIFICITY, UROKINASE, TRYPSIN, THROMBIN, ZN+2-MEDIATED INHIBITION, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1gi4:A (CYS136) to (SER202) A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI- CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE | THREE-CENTERED, VERY SHORT HYDROGEN BOND, OXYANION HOLE WATER, SHIFT OF PKA OF HIS57, STRUCTURE-BASED DRUG DESIGN, SPECIFICITY, UROKINASE, TRYPSIN, THROMBIN, ZN+2-MEDIATED INHIBITION, HYDROLASE
1gi8:B (THR134) to (SER202) A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI- CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE | THREE-CENTERED, VERY SHORT HYDROGEN BOND, OXYANION HOLE WATER, SHIFT OF PKA OF HIS57, STRUCTURE-BASED DRUG DESIGN, SPECIFICITY, UROKINASE, TRYPSIN, THROMBIN, ZN+2-MEDIATED INHIBITION, BLOOD CLOTTING, HYDROLASE
1gj4:H (TYR134) to (SER203) SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN | THREE-CENTERED, VERY SHORT HYDROGEN BOND, OXYANION HOLE WATER, SHIFT OF PKA OF HIS57, STRUCTURE-BASED DRUG DESIGN, SPECIFICITY, UROKINASE, TRYPSIN, THROMBIN, ZN+2-MEDIATED INHIBITION, BLOOD CLOTTING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1gj8:B (CYS136) to (SER202) ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS | SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN, BLOOD CLOTTING, HYDROLASE
1gjb:B (CYS136) to (GLN204) ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS | SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN, BLOOD CLOTTING, HYDROLASE
1gjc:B (SER135) to (SER202) ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS | SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN, BLOOD CLOTTING, HYDROLASE
1gl1:A (CYS136) to (LYS202) STRUCTURE OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-C, AN INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA | HYDROLASE/INHIBITOR, COMPLEX (PROTEASE/INHIBITOR), HYDROLASE, SERINE PROTEASE, SERINE PROTEASE INHIBITOR
1gl0:E (CYS136) to (LYS202) STRUCTURE OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-D2V, AN INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA | HYDROLASE/INHIBITOR, COMPLEX (PROTEASE/INHIBITOR), HYDROLASE, SERINE PROTEASE, SERINE PROTEASE INHIBITOR
2fww:D (PRO135) to (LYS202) HUMAN BETA-TRYPTASE II COMPLEXED WITH 4-PIPERIDINEBUTYRATE TO MAKE ACYLENZYME | SERINE PROTEASE, PROTEINASE, 29382, HYDROLASE
2fxr:D (PRO135) to (LYS202) HUMAN BETA TRYPTASE II COMPLEXED WITH ACTIVATED KETONE INHIBITOR CRA-29382 | SERINE PROTEASE, ACTIVATED KETONE INHIBITOR, PYRROLIDINE, CRA-29382, HYDROLASE
1sgi:E (TYR134) to (PRO204) CRYSTAL STRUCTURE OF THE ANTICOAGULANT SLOW FORM OF THROMBIN | THROMBIN, ALLOSTERY, HYDROLASE
1shh:B (TYR134) to (SER203) SLOW FORM OF THROMBIN BOUND WITH PPACK | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2fzz:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(3-AMINO-1,2- BENZISOXAZOL-5-YL)-6-(2'-(((3R)-3-HYDROXY-1-PYRROLIDINYL) METHYL)-4-BIPHENYLYL)-3-(TRIFLUOROMETHYL)-1,4,5,6- TETRAHYDRO-7H-PYRAZOLO[3,4-C]PYRIDIN-7-ONE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING
2g00:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 3-(6-(2'- ((DIMETHYLAMINO)METHYL)-4-BIPHENYLYL)-7-OXO-3- (TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4- C]PYRIDIN-1-YL)BENZAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING
1shy:A (SER611) to (GLN681) THE CRYSTAL STRUCTURE OF HGF BETA-CHAIN IN COMPLEX WITH THE SEMA DOMAIN OF THE MET RECEPTOR. | PROTEASE, SEMA DOMAIN, PSI DOMAIN, RECEPTOR ECTODOMAIN GROWTH FACTOR, GROWTH FACTOR-GROWTH FACTOR RECEPTOR COMPLEX
1slu:B (CYS136) to (ASN202) RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN | SERINE PROTEASE, INHIBITOR, COMPLEX, METAL BINDING SITES, PROTEIN ENGINEERING, PROTEASE-SUBSTRATE INTERACTIONS, METALLOPROTEINS, COMPLEX (SERINE PROTEASE-INHIBITOR) COMPLEX
2g52:A (SER131) to (ASP201) ANOMALOUS SUBSTRUCTURE OF TRYPSIN (P21) | ANOMALOUS SUBSTRUCTURE OF TRYPSIN (P21), HYDROLASE
4zh8:A (GLY136) to (LYS204) FACTOR XA COMPLEX WITH GTC000006 | HYDROLASE, INHIBITOR
4zha:A (GLY136) to (PHE203) FACTOR XA COMPLEX WITH GTC000102 | HYDROLASE, INHIBITOR
2vvc:A (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, ZYMOGEN, PROTEASE, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN
2vvc:B (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, ZYMOGEN, PROTEASE, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN
2vvu:A (GLY136) to (LYS204) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
2vvv:A (GLY136) to (PHE203) AMINOPYRROLIDINE-RELATED TRIAZOLE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
1gvl:A (CYS136) to (GLY202) HUMAN PROKALLIKREIN 6 (HK6)/ PROZYME/ PROPROTEASE M/ PRONEUROSIN | HYDROLASE, ZYMOGEN, HUMAN KALLIKREIN
2vwl:A (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
2vwm:A (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
2vwm:B (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
2vwn:A (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
4zj4:A (THR134) to (HIS203) THE CRYSTAL STRUCTURE OF HUMAN PLASMA KALLIKREIN IN COMPLEX WITH ITS PEPTIDE INHIBITOR PKALIN-1 | PEPTIDE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR
4zj5:A (THR134) to (HIS203) THE CRYSTAL STRUCTURE OF HUMAN PLASMA KALLIKREIN IN COMPLEX WITH ITS PEPTIDE INHIBITOR PKALIN-2 | PEPTIDE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1t4v:H (TYR170) to (SER243) CRYSTAL STRUCTURE ANALYSIS OF A NOVEL OXYGUANIDINE BOUND TO THROMBIN | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1t7c:A (CYS136) to (LYS202) CRYSTAL STRUCTURE OF THE P1 GLU BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | CHYMOTRYPSIN; SERINE PROTEINASE; BOVINE PANCREATIC TRYPSIN INHIBITOR; BPTI; PROTEIN-PROTEIN INTERACTION; NON-COGNATE BINDING; S1 POCKET; PRIMARY SPECIFICITY; CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
2w3i:A (GLY136) to (LYS204) CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 4,4-DISUBSTITUTED PYRROLIDINE-1,2-DICARBOXAMIDE INHIBITOR 2 | DRUG DESIGN, GLYCOPROTEIN, HYDROXYLATION, BLOOD CLOTTING, SERINE PROTEASE, EGF-LIKE DOMAIN, FXA COAGULATION FACTOR INHIBITOR, ZYMOGEN, PROTEASE, SECRETED, HYDROLASE, BLOOD COAGULATION, GAMMA-CARBOXYGLUTAMIC ACID, CLEAVAGE ON PAIR OF BASIC RESIDUES
1t8l:A (THR135) to (LYS202) CRYSTAL STRUCTURE OF THE P1 MET BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | CHYMOTRYPSIN; SERINE PROTEINASE; BOVINE PANCREATIC TRYPSIN INHIBITOR; BPTI; PROTEIN-PROTEIN INTERACTION; NON-COGNATE BINDING; S1 POCKET; PRIMARY SPECIFICITY; CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1t8m:A (CYS136) to (LYS202) CRYSTAL STRUCTURE OF THE P1 HIS BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | CHYMOTRYPSIN, SERINE PROTEINASE, BOVINE PANCREATIC TRYPSIN INHIBITOR, BPTI, PROTEIN-PROTEIN INTERACTION, NON-COGNATE BINDING; S1 POCKET, PRIMARY SPECIFICITY, CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
3iit:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A CIS-1,2-DIAMINOCYCLOHEXANE DERIVATIVE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, HYDROXYLATION, PROTEASE, SECRETED, ZYMOGEN
1h8d:H (TYR134) to (SER203) X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR. | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1h8i:H (TYR134) to (SER203) X-RAY CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR. | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hag:E (TYR134) to (SER203) THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK- THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN | COMPLEX(SERINE PROTEINASE-INHIBITOR),HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hah:H (TYR134) to (SER203) THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK- THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN | COMPLEX(SERINE PROTEINASE-INHIBITOR), COMPLEX(SERINE PROTEINASE- INHIBITOR) COMPLEX
1tb6:H (TYR134) to (SER203) 2.5A CRYSTAL STRUCTURE OF THE ANTITHROMBIN-THROMBIN-HEPARIN TERNARY COMPLEX | HEPARIN, HYDROLASE-BLOOD CLOTTING COMPLEX
1tbq:H (PHE134) to (PRO204) CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN | COMPLEX (SERINE PROTEASE/INHIBITOR), KAZAL-TYPE INHIBITOR, THROMBIN
1tbq:K (PHE134) to (PRO204) CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN | COMPLEX (SERINE PROTEASE/INHIBITOR), KAZAL-TYPE INHIBITOR, THROMBIN
1tbr:H (PHE134) to (PRO204) CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN | COMPLEX (SERINE PROTEASE-INHIBITOR), KAZAL-TYPE INHIBITOR, THROMBIN, COMPLEX (SERINE PROTEASE-INHIBITOR) COMPLEX
1tbr:K (PHE134) to (SER203) CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN | COMPLEX (SERINE PROTEASE-INHIBITOR), KAZAL-TYPE INHIBITOR, THROMBIN, COMPLEX (SERINE PROTEASE-INHIBITOR) COMPLEX
1tfx:B (GLU135) to (ASN202) COMPLEX OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR WITH PORCINE TRYPSIN | COMPLEX (SERINE PROTEASE/INHIBITOR), HYDROLASE, INHIBITOR, BLOOD COAGULATION
1hdt:H (TYR134) to (SER203) STRUCTURE OF A RETRO-BINDING PEPTIDE INHIBITOR COMPLEXED WITH HUMAN ALPHA-THROMBIN | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ths:H (TYR134) to (SER203) STRUCTURES OF THROMBIN COMPLEXES WITH A DESIGNED AND A NATURAL EXOSITE INHIBITOR | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hgt:H (TYR134) to (SER203) STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA- THROMBIN | HYDROLASE(SERINE PROTEASE)
1hlt:H (TYR134) to (SER203) THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hlt:K (TYR134) to (SER203) THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2h9e:H (GLY136) to (LYS204) CRYSTAL STRUCTURE OF FXA/SELECTIDE/NAPC2 TERNARY COMPLEX | FACTOR XA, NAPC2, SELECTIDE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, BLOOD CLOTTING
4zxx:H (SER136) to (TYR203) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1- AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4- (PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1try:A (SER134) to (ASP201) STRUCTURE OF INHIBITED TRYPSIN FROM FUSARIUM OXYSPORUM AT 1.55 ANGSTROMS | HYDROLASE (SERINE PROTEINASE)
2hlc:A (ALA136) to (LEU201) HL COLLAGENASE STRUCTURE AT 1.7A RESOLUTION | SERINE PROTEASE, HYDROLASE, COLLAGEN DEGRADATION
2hlc:B (ALA136) to (LEU201) HL COLLAGENASE STRUCTURE AT 1.7A RESOLUTION | SERINE PROTEASE, HYDROLASE, COLLAGEN DEGRADATION
1hxe:H (TYR134) to (SER203) SERINE PROTEASE | SERINE PROTEASE IN BLOOD COAGULATION, HYDROLASE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASEE-HYDROLASE INHIBITOR COMPLEX
1hxf:H (TYR134) to (MET201) HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT | COMPLEX (SERINE PROTEASE INHIBITOR), SULFATATION, MULTIGENE FAMILY, BLOOD COAGULATION, PLASMA, CALCIUM-BINDING, GLYCOPROTEIN, DUPLICATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2hpq:H (TYR134) to (SER203) STRUCTURES OF THE NONCOVALENT COMPLEXES OF HUMAN AND BOVINE PROTHROMBIN FRAGMENT 2 WITH HUMAN PPACK-THROMBIN | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lxb:H (TYR134) to (SER203) CRYSTAL STRUCTURE ANALYSIS OF THROMBIN IN COMPLEX WITH COMPOUND D58 | SERINE PROTEASES, ANTITHROMBOTIC AGENTS, DUAL THROMBIN/FACTOR XA INHI, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2hwl:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH FIBRINOGEN GAMMA' PEPTIDE | THROMBIN, FIBRINOGEN, GAMMA' PEPTIDE, SERINE PROTEASE STRUCTURE, ALLOSTERY, HYDROLASE
2hwl:D (TYR134) to (SER203) CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH FIBRINOGEN GAMMA' PEPTIDE | THROMBIN, FIBRINOGEN, GAMMA' PEPTIDE, SERINE PROTEASE STRUCTURE, ALLOSTERY, HYDROLASE
4lz4:B (TYR134) to (SER203) X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN THROMBIN AND THE TBA DELETION MUTANT LACKING THYMINE 3 NUCLEOBASE | PROTEIN-DNA COMPLEX, DNA APTAMER, G-QUADRUPLEX, TBA DELETION MUTANT, SERINE PROTEASE, HYDROLASE, BLOOD COAGULATION, BLOOD, HYDROLASE-DNA COMPLEX, HYDROLASE-HYDROLASE INHIBITOR-DNA COMPLEX
1ucy:K (PHE134) to (SER203) THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A ALPHA (RESIDUES 7- 19). THREE COMPLEXES, ONE WITH EPSILON-THROMBIN AND TWO WITH ALPHA-THROMBIN | COMPLEX (SERINE PROTEASE/COAGULATION), SERINE, PROTEASE, THROMBIN
1ucy:N (PHE134) to (SER203) THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A ALPHA (RESIDUES 7- 19). THREE COMPLEXES, ONE WITH EPSILON-THROMBIN AND TWO WITH ALPHA-THROMBIN | COMPLEX (SERINE PROTEASE/COAGULATION), SERINE, PROTEASE, THROMBIN
1ihs:H (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON- HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6 | HYDROLASE(SERINE PROTEINASE), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1iht:H (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON- HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6 | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1uma:H (TYR134) to (SER203) ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)- ALPHA-AZALYSINE | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE, KRINGLE, ALPHA-THROMBIN- HIRUGEN COMPLEX
4m7g:A (ALA119) to (ASN186) STREPTOMYCES ERYTHRAEUS TRYPSIN | SERINE PROTEASE, HYDROLASE
2wyj:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS | BLOOD CLOTTING, SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, HYDROLASE, HYDROXYLATION, ZYMOGEN
1uvt:H (PHE134) to (PRO204) BOVINE THROMBIN--BM14.1248 COMPLEX | SERINE PROTEASE, HYDROLASE, THROMBIN, BLOOD COAGULATION
5af9:H (TYR134) to (SER203) THROMBIN IN COMPLEX WITH 4-METHOXY-N-(2-PYRIDINYL)BENZAMIDE | HYDROLASE, HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, FRAGMENT, GLYCOSYLATION, BLOOD
5ahg:H (TYR134) to (SER203) THROMBIN IN COMPLEX WITH ((4-CHLOROPHENYL)SULFAMOYL)) DIEMETHYLAMINE | HYDROLASE, HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, FRAGMENT, GLYCOSYLATION, BLOOD
1j9c:H (SER136) to (ARG204) CRYSTAL STRUCTURE OF TISSUE FACTOR-FACTOR VIIA COMPLEX | MOBILE LOOP, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2xbv:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION FACTOR, HYDROLASE, HYDROXYLATION, SERINE PROTEASE, ZYMOGEN
2xbw:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION FACTOR, HYDROLASE, HYDROXYLATION, SERINE PROTEASE, ZYMOGEN
2xbx:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION, COAGULATION FACTOR, HYDROLASE, HYDROXYLATION, SERINE PROTEASE, ZYMOGEN
2xby:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION, COAGULATION FACTOR, HYDROLASE, HYDROXYLATION, SERINE PROTEASE, ZYMOGEN
2xc5:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION, COAGULATION FACTOR, HYDROLASE, HYDROXYLATION, SERINE PROTEASE, ZYMOGEN
2j2u:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | GAMMA- CARBOXYGLUTAMIC ACID, SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, GAMMA-CARBOXYGLUTAMIC ACID, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE
2j38:A (GLY136) to (LYS204) CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | GAMMA- CARBOXYGLUTAMIC ACID, SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, GAMMA-CARBOXYGLUTAMIC ACID, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE
4mqa:A (PRO154) to (LYS231) HUMAN BETA-TRYPTASE CO-CRYSTAL STRUCTURE WITH {(1,1,3,3- TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1- DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE) | COFERON, ALPHA-HYDROXYKETONE, SMALL MOLECULE INHIBITOR, DRUG DISCOVERY, SELF-ASSEMBLY, CRYSTAL CATALYSIS, SILANOL, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1jmo:H (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE HEPARIN COFACTOR II-S195A THROMBIN COMPLEX | SERPIN, THROMBIN, PROTEASE, INHIBITION, INHIBITOR, BLOOD CLOTTING
1jou:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF NATIVE S195A THROMBIN WITH AN UNOCCUPIED ACTIVE SITE | PROTEASE, PROTEINASE, THROMBIN, FACTOR IIA, ENZYME, BLOOD CLOTTING
1jou:D (TYR134) to (SER203) CRYSTAL STRUCTURE OF NATIVE S195A THROMBIN WITH AN UNOCCUPIED ACTIVE SITE | PROTEASE, PROTEINASE, THROMBIN, FACTOR IIA, ENZYME, BLOOD CLOTTING
1jou:F (TYR134) to (SER203) CRYSTAL STRUCTURE OF NATIVE S195A THROMBIN WITH AN UNOCCUPIED ACTIVE SITE | PROTEASE, PROTEINASE, THROMBIN, FACTOR IIA, ENZYME, BLOOD CLOTTING
1vr1:H (TYR134) to (SER203) SPECIFITY FOR PLASMINOGEN ACTIVATOR INHIBITOR-1 | THROMBIN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1w0y:H (SER136) to (ARG204) TF7A_3771 COMPLEX | SERINE PROTEASE, HYDROLASE, BLOOD COAGULATION, GLYCOPROTEIN, PLASMA, VITAMIN K, CALCIUM-BINDING, GAMMA-CARBOXYGLUTAMIC ACID, CO-FACTOR, COAGULATION, ENZYME COMPLEX
1jwt:A (GLY172) to (SER243) CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR | HYDROLASE
1w7g:H (TYR134) to (SER203) ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L- ARGININE TEMPLATE INHIBITOR CS107 | BLOOD COAGULATION-INHIBITOR, THROMBIN, ARGATROBAN, SERINE PROTEASE, COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2jh0:D (TYR134) to (SER203) HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX | GLYCOPROTEIN, SERINE PROTEASE, KRINGLE, ZYMOGEN, THROMBIN, PROTEASE, DISEASE MUTATION, BLOOD COAGULATION, GAMMA-CARBOXYGLUTAMIC ACID, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, SULFATION, ACUTE PHASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2jh5:D (TYR134) to (SER203) HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX | GLYCOPROTEIN, SERINE PROTEASE, KRINGLE, ZYMOGEN, THROMBIN, PROTEASE, DISEASE MUTATION, BLOOD COAGULATION, GAMMA-CARBOXYGLUTAMIC ACID, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, SULFATION, ACUTE PHASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2xwb:F (LYS604) to (ARG683) CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTORS B AND D | IMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY
2xwb:H (LYS604) to (LYS682) CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTORS B AND D | IMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY
4na9:H (SER136) to (TYR203) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 3'-AMINO-5'-[(2S,4R)-6- CARBAMIMIDOYL-4-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-2-YL]BIPHENYL-2- CARBOXYLIC ACID | SERINE PROTEASE, HYDROLASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, GLYCOPROTEIN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1k21:H (TYR134) to (SER203) HUMAN THROMBIN-INHIBITOR COMPLEX | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1k22:H (TYR134) to (SER203) HUMAN THROMBIN-INHIBITOR COMPLEX | COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2xwj:I (LYS604) to (LYS682) CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B | IMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY
2xwj:J (LYS604) to (LYS682) CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B | IMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY
2xwj:K (LYS604) to (LYS682) CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B | IMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY
2xwj:L (LYS604) to (LYS682) CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B | IMMUNE SYSTEM, PRO-CONVERTASE, HYDROLASE, SERINE PROTEASE, CONFORMATIONAL CHANGES, ALTERNATIVE PATHWAY
1way:B (TYR134) to (SER203) ACTIVE SITE THROMBIN INHIBITORS | PROTEASE, BLOOD COAGULATION, ACUTE PHASE, CALCIUM-BINDING, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PLASMA, SERINE PROTEASE, VITAMIN K, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2xxl:A (SER258) to (ALA324) CRYSTAL STRUCTURE OF DROSOPHILA GRASS CLIP SERINE PROTEASE OF TOLL PATHWAY | HYDROLASE, INNATE IMMUNITY
2xxl:B (SER258) to (ALA324) CRYSTAL STRUCTURE OF DROSOPHILA GRASS CLIP SERINE PROTEASE OF TOLL PATHWAY | HYDROLASE, INNATE IMMUNITY
1wbg:B (TYR134) to (SER203) ACTIVE SITE THROMBIN INHIBITORS | BLOOD COAGULATION-INHIBITOR, SERINE PROTEASE, BLOOD COAGULATION, ACUTE PHASE, CALCIUM-BINDING, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, POLYMORPHISME, VITAMIN K, ZYMOGEN, SULFATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ng9:H (SER136) to (ARG204) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (2R)-2-[(1-AMINOISOQUINOLIN- 6-YL)AMINO]-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-N-(3- SULFAMOYLBENZYL)ETHANAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4niw:A (GLN135) to (CYS201) CRYSTAL STRUCTURE OF TRYPSILIGASE (K60E/N143H/Y151H/D189K TRYPSIN) ORTHORHOMBIC FORM | TRYPSIN, SERINE PROTEINASE, ENZYME DESIGN, ACTIVATION DOMAIN, ZYMOGEN, PEPTIDE LIGATION, REVERSE PROTEOLYSIS, HYDROLASE
4nix:A (GLN135) to (CYS201) CRYSTAL STRUCTURE OF TRYPSILIGASE (K60E/N143H/Y151H/D189K TRYPSIN) ORTHORHOMBIC FORM, ZINC-BOUND | TRYPSIN, SERINE PROTEINASE, ENZYME DESIGN, ACTIVATION DOMAIN, ZYMOGEN, PEPTIDE LIGATION, REVERSE PROTEOLYSIS, HYDROLASE
1wqv:H (SER136) to (ARG204) HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH PROPYLSULFONAMIDE-D- THR-MET-P-AMINOBENZAMIDINE | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1wss:H (SER136) to (ARG204) HUMAN FACTOR VIIA-TISSUE FACTOR IN COMPLEX WITH PEPTIDE-MIMETIC INHIBITOR THAT HAS TWO CHARGED GROUPS IN P2 AND P4 | SERINE PROTEASE, HYDROLASE-BLOOD CLOTTING COMPLEX
1wtg:H (SER136) to (ARG204) HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-BIPHENYLALANINE-GLN-P-AMINOBENZAMIDINE | SERINE PROTEASE, HYDROLASE/BLOOD CLOTTING COMPLEX
1wu1:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 4-[(5-CHLOROINDOL-2-YL) SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL) PYRIMIDIN-2- YL]CARBONYL]PIPERAZINE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING
2y7x:A (GLY136) to (LYS204) THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS | BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE
2y7z:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS | BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION
2y80:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS | BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION
2y81:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS | BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION PROTEASE
1wv7:H (SER136) to (ARG204) HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-5-PROPOXY-TRP-GLN-P-AMINOBENZAMIDINE | SERINE PROTEASE, HYDROLASE/BLOOD CLOTTING COMPLEX
1kig:H (GLY136) to (PHE203) BOVINE FACTOR XA | GLYCOPROTEIN, SERINE PROTEASE, PLASMA, BLOOD COAGULATION, COMPLEX (PROTEASE/INHIBITOR)
1x7a:C (GLY136) to (GLU204) PORCINE FACTOR IXA COMPLEXED TO 1-{3-[AMINO(IMINO) METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]- 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE | INHIBITION; X-RAY STRUCTURE, BLOOD CLOTTING,HYDROLASE
1ksn:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH FXV673 | HYDROLASE
1kts:B (GLY136) to (SER203) THROMBIN INHIBITOR COMPLEX | BLOOD COAGULATION, INHIBITION, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ktt:B (TYR134) to (SER203) THROMBIN INHIBITOR COMPLEX | BLOOD COAGULATION, INHIBITION, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4nzq:A (TYR454) to (SER533) CRYSTAL STRUCTURE OF CA2+-FREE PROTHROMBIN DELETION MUTANT RESIDUES 146-167 | PROTHROMBIN, KRINGLE, SERINE PROTEASE, COAGULATION, HYDROLASE
1kyn:A (LEU135) to (ASN202) CATHEPSIN-G | SERINE PROTEASE, HYDROLASE
1l2e:A (SER135) to (GLY202) HUMAN KALLIKREIN 6 (HK6) ACTIVE FORM WITH BENZAMIDINE INHIBITOR | SERINE PROTEASE, KALLIKREIN, HUMAN KALLIKREIN 6, BENZAMIDINE, PROTEASE, MYELENCEPHALON SPECIFIC PROTEASE, ZYME, PROTEASE M, NEUROSIN, HYDROLASE
4o3u:A (SER611) to (GLU670) ZYMOGEN HGF-BETA/MET WITH ZYMOGEN ACTIVATOR PEPTIDE ZAP2.3 | TRYPSIN HOMOLOY, RECEPTOR ACTIVATION, TRANSFERASE-GROWTH FACTOR COMPLEX
1l4d:A (GLU679) to (ALA731) CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX | STREPTOKINASE, PLASMINOGEN, PROTEIN COMPLEX, CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE ACTIVATOR COMPLEX
5ce1:A (CYS291) to (SER362) CRYSTAL STRUCTURE OF SERINE PROTEASE HEPSIN IN COMPLEX WITH INHIBITOR | SERINE PROTEASE, HEPSIN, PROSTATE CANCER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3jz2:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF HUMAN THROMBIN MUTANT N143P IN E* FORM | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, ZYMOGEN
1lhg:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO- BOROORNITHINE-OH | BLOOD COAGULATION, PLASMA, CALCIUM-BINDING, GLYCOPROTEIN, DUPLICATION, VITAMIN K, ZYMOGEN, GAMMA-CARBOXYGLUTAMIC ACID, ACUTE PHASE, LIVER, HYDROLASE, SERINE PROTEASE, KRINGLE, SIGNAL, DISEASE MUTATION, COMPLEX (SERINE PROTEASE/INHIBITOR)
5cmx:H (TYR134) to (SER203) X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND A DUPLEX/QUADRUPLEX 31-MER DNA APTAMER | DNA APTAMER, DUPLEX/G-QUADRUPLEX FOLD, THROMBIN, EXOSITE I, HYDROLASE
1lpg:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79. | PROTEIN INHIBITOR COMPLEX, BLOOD COAGULATION FACTOR, SERINE PROTEINASE, HYDROLASE
1lqd:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45. | PROTEIN-INHIBITOR COMPLEX, BLOOD COAGULATION FACTOR, SERINE PROTEINASE, HYDROLASE
3k65:B (TYR454) to (SER533) CRYSTAL STRUCTURE OF PRETHOMBIN-2/FRAGMENT-2 COMPLEX | PROTHROMBIN, COAGULATION, ZYMOGEN, HYDROLASE
1xkb:C (GLY136) to (PHE203) FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'- AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID | BLOOD COAGULATION FACTOR, SERINE PROTEINASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN
1xkb:D (GLY136) to (LYS204) FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'- AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID | BLOOD COAGULATION FACTOR, SERINE PROTEINASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN
1lto:A (PRO135) to (LYS202) HUMAN ALPHA1-TRYPTASE | HYDROLASE
1lto:D (PRO135) to (LYS202) HUMAN ALPHA1-TRYPTASE | HYDROLASE
2za5:B (PRO139) to (LYS216) CRYSTAL STRUCTURE OF HUMAN TRYPTASE WITH POTENT NON-PEPTIDE INHIBITOR | TRYPTASE, SERINE PROTEASE, TETRAMER, HYDROLASE
2za5:D (PRO139) to (LYS216) CRYSTAL STRUCTURE OF HUMAN TRYPTASE WITH POTENT NON-PEPTIDE INHIBITOR | TRYPTASE, SERINE PROTEASE, TETRAMER, HYDROLASE
1xmn:F (TYR134) to (SER203) CRYSTAL STRUCTURE OF THROMBIN BOUND TO HEPARIN | BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4a7i:B (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A POTENT 2-AMINO-ETHANE SULFONAMIDE INHIBITOR | BLOOD COAGULATION FACTOR, CALCIUM- BINDING, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, SERINE PROTEINASE, SERINE PROTEASE
2zda:H (TYR134) to (SER203) EXPLORING THROMBIN S1 POCKET | BLOOD CLOTTING/HYDROLASE INHIBITORS, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
2zec:A (PRO139) to (LYS216) POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TRYPTASE | TRYPTASE, SERINE PROTEASE, HYDROLASE
2zec:D (PRO139) to (LYS216) POTENT, NONPEPTIDE INHIBITORS OF HUMAN MAST CELL TRYPTASE | TRYPTASE, SERINE PROTEASE, HYDROLASE
2zff:H (TYR134) to (SER203) EXPLORING THROMBIN S1-POCKET | BLOOD CLOTTING/HYDROLASE INHIBITORS, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
3k9x:B (GLY136) to (PHE203) X-RAY CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH (S)-N-((2- METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL) ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE | SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF- LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING, BLOOD COAGULATION, DISULFIDE BOND, PROTEASE, SECRETED
2zfq:H (TYR134) to (SER203) EXPLORING THROMBIN S3 POCKET | BLOOD COAGULATION/HYDROLASE INHIBITORS, ACUTE PHASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, SULFATION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2zhq:H (TYR134) to (SER203) THROMBIN INHIBITION | BLOOD CLOTTING, HYDROLASE INHIBITOR, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kcg:H (GLY136) to (VAL203) CRYSTAL STRUCTURE OF THE ANTITHROMBIN-FACTOR IXA- PENTASACCHARIDE COMPLEX | MICHAELIS COMPLEX, BLOOD COAGULATION, CALCIUM, DISULFIDE BOND, EGF-LIKE DOMAIN, GLYCOPROTEIN, HEMOPHILIA, HYDROLASE, PHARMACEUTICAL, PROTEASE, SECRETED, SERINE PROTEASE, SULFATION, ZYMOGEN, HEPARIN-BINDING, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, THROMBOPHILIA
2zks:A (ARG119) to (GLY189) STRUCTURAL INSIGHTS INTO THE PROTEOLYTIC MACHINERY OF APOPTOSIS- INDUCING GRANZYME M | SERINE PROTEASE, GRANZYME, CYTOLYSIS, GLYCOPROTEIN, HYDROLASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xug:A (CYS136) to (SER202) TRYPSIN-BABIM-ZN+2, PH 8.2 | COMPLEX, TRYPSIN-ZN+2-SMALL MOLECULE LIGAND, DESIGNED SMALL MOLECULE LIGAND WITH NANOMOLAR AFFINITY, SERINE PROTEASE
2zp0:H (SER136) to (ARG204) HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH BENZYLSULFONAMIDE-D- ILE-GLN-P-AMINOBENZAMIDINE | SERINE PROTEASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, PROTEASE, ZYMOGEN, LIPOPROTEIN, MEMBRANE, PALMITATE, TRANSMEMBRANE, HYDROLASE-BLOOD CLOTTING COMPLEX
1xx9:A (ASP135) to (LYS202) CRYSTAL STRUCTURE OF THE FXIA CATALYTIC DOMAIN IN COMPLEX WITH ECOTINM84R | FXIA; CATALYTIC DOMAIN; SERINE PROTEIN; ECOTIN, BLOOD CLOTTING- HYDROLASE INHIBITOR COMPLEX
1xxd:A (ASP135) to (HIS202) CRYSTAL STRUCTURE OF THE FXIA CATALYTIC DOMAIN IN COMPLEX WITH MUTATED ECOTIN | FXIA; CATALYTIC DOMAIN; SERINE PROTEIN; ECOTIN, BLOOD CLOTTING/HYDROLASE INHIBITOR COMPLEX
1md8:A (LEU572) to (ARG644) MONOMERIC STRUCTURE OF THE ACTIVE CATALYTIC DOMAIN OF COMPLEMENT PROTEASE C1R | COMPLEMENT, INNATE IMMUNITY, SERINE PROTEASE, ACTIVATION, SUBSTRATE SPECIFICITY, HYDROLASE
1mgv:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE R391A MUTANT OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER, TRANSFERASE
1mgv:B (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE R391A MUTANT OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER, TRANSFERASE
1mkx:K (GLY136) to (PRO204) THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA- THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING | COMPLEX (BLOOD COAGULATION/PROENZYME), THROMBIN, PRETHROMBIN-2, PLASMA, SERINE PROTEASE
1mly:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE IN COMPLEX WITH THE CIS ISOMER OF AMICLENOMYCIN | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, AMICLENOMYCIN, TRANSFERASE
1mly:B (GLU36) to (ALA86) CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE IN COMPLEX WITH THE CIS ISOMER OF AMICLENOMYCIN | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, AMICLENOMYCIN, TRANSFERASE
1mlz:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE IN COMPLEX WITH THE TRANS-ISOMER OF AMICLENOMYCIN. | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, AMICLENOMYCIN, TRANSFERASE
2zzu:H (SER136) to (ARG204) HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-5- (3-CARBOXYBENZYLOXY)-TRP-GLN-P-AMINOBENZAMIDINE | SERINE PROTEASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, PROTEASE, ZYMOGEN, LIPOPROTEIN, MEMBRANE, PALMITATE, TRANSMEMBRANE, HYDROLASE-BLOOD CLOTTING COMPLEX, SECRETED
1mq5:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF 3-CHLORO-N-[4-CHLORO-2-[[(4-CHLOROPHENYL) AMINO]CARBONYL]PHENYL]-4-[(4-METHYL-1-PIPERAZINYL)METHYL]-2- THIOPHENECARBOXAMIDE COMPLEXED WITH HUMAN FACTOR XA | PROTEIN INHIBITOR COMPLEX, COAGULATION COFACTOR, PROTEASE, BLOOD CLOTTING
1mq6:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF 3-CHLORO-N-[4-CHLORO-2-[[(5-CHLORO-2-PYRIDINYL) AMINO]CARBONYL]-6-METHOXYPHENYL]-4-[[(4,5-DIHYDRO-2-OXAZOLYL) METHYLAMINO]METHYL]-2-THIOPHENECARBOXAMIDE COMPLEXED WITH HUMAN FACTOR XA | PROTEIN INHIBITOR COMPLEX, COAGULATION COFACTOR, PROTEASE, BLOOD CLOTTING
3kqe:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 3-METHYL-1-(3-(5- OXO-4,5- DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-6-(2'- (PYRROLIDIN-1-YLMETHYL) BIPHENYL-4-YL)-5,6-DIHYDRO-1H- PYRAZOLO[3,4-C]PYRIDIN-7(4H)-ONE | GLYCOPROTEIN, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, BLOOD COAGULATION, CALCIUM, PROTEASE, SECRETED, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, HYDROLASE
1ybw:A (CYS535) to (ASN607) PROTEASE DOMAIN OF HGFA WITH NO INHIBITOR | HYDROLASE
1ybw:B (CYS535) to (ASN607) PROTEASE DOMAIN OF HGFA WITH NO INHIBITOR | HYDROLASE
1yc0:A (CYS535) to (LYS606) SHORT FORM HGFA WITH FIRST KUNITZ DOMAIN FROM HAI-1 | HYDROLASE/INHIBITOR, HYDROLASE-INHIBITOR COMPLEX
1mu8:B (TYR134) to (SER203) THROMBIN-HIRUGEN_L-378,650 | THROMBIN-HIRUGEN, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1mue:B (TYR134) to (SER203) THROMBIN-HIRUGEN-L405,426 | ALPHA THROMBIN-HIRUGEN, BLOOD CLOTTING COMPLEX,HYDROLASE INHIBITOR COMPLEX, HYDROLASE INHIBITOR
3a82:A (CYS134) to (SER202) CRYSTAL STRUCTURE OF TRYPSIN COMPLEXED WITH PRE-SYNTHESIZED (E)-2-(4- CARBAMIMIDOYLBENZYLIDENEAMINOOXY)ACETIC ACID | IN-CRYSTAL CHEMICAL LIGATION, DIGESTION, DISULFIDE BOND, HYDROLASE, METAL-BINDING, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN
1mza:A (LYS135) to (CYS201) CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYME K | GRANZYME, APOPTOSIS, SERINE PROTEASE, S1 FAMILY, HYDROLASE
1mzd:A (LYS135) to (CYS201) CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYME K | GRANZYME, APOPTOSIS, SERINE PROTEASE, S1 FAMILY, HYDROLASE
1ype:H (TYR134) to (SER203) THROMBIN INHIBITOR COMPLEX | THROMBIN, INHIBITOR COMPLEX, BARREL, 6 STRANDED BETA-SHEET, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1ypg:H (TYR134) to (SER203) THROMBIN INHIBITOR COMPLEX | THROMBIN, INHIBITOR COMPLEX, BARREL, 6 STRANDED BETA-SHEET, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1ypj:H (TYR134) to (SER203) THROMBIN INHIBITOR COMPLEX | THROMBIN, INHIBITOR COMPLEX, BARREL, 6 STRANDED BETA-SHEET, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
1ypk:H (TYR134) to (SER203) THROMBIN INHIBITOR COMPLEX | THROMBIN, INHIBITOR COMPLEX, BARREL, 6 STRANDED BETA-SHEET, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5do4:H (TYR134) to (SER213) THROMBIN-RNA APTAMER COMPLEX | THROMBIN-RNA APTAMER, PHOSPHORODITHIOATE RNA, PS2-RNA, PS2 LINKAGE, HYDROLASE-RNA COMPLEX
3lc3:A (GLY136) to (GLU204) BENZOTHIOPHENE INHIBITORS OF FACTOR IXA | PROTEIN-INHIBITOR COMPLEX, PEPTIDASE S1, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HEMOPHILIA, HYDROLASE, HYDROXYLATION, PHARMACEUTICAL, PHOSPHOPROTEIN, POLYMORPHISM, PROTEASE, SECRETED, SERINE PROTEASE, SULFATION, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3lc3:C (GLY136) to (VAL203) BENZOTHIOPHENE INHIBITORS OF FACTOR IXA | PROTEIN-INHIBITOR COMPLEX, PEPTIDASE S1, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HEMOPHILIA, HYDROLASE, HYDROXYLATION, PHARMACEUTICAL, PHOSPHOPROTEIN, POLYMORPHISM, PROTEASE, SECRETED, SERINE PROTEASE, SULFATION, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1z6e:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(3'-AMINO-1,2-BENZISOXAZOL- 5'-YL)-N-(4-(2'-((DIMETHYLAMINO)METHYL)-1H-IMIDAZOL-1-YL)-2- FLUOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE (RAZAXABAN; DPC906; BMS-561389) | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN
1z71:A (TYR134) to (SER203) THROMBIN AND P2 PYRIDINE N-OXIDE INHIBITOR COMPLEX STRUCTURE | THROMBIN INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1z7k:A (CYS136) to (ASN202) CRYSTAL STRUCTURE OF TRYPSIN- OVOMUCOID TURKEY EGG WHITE INHIBITOR COMPLEX | SERINE PROTEASE, HYDROLASE, PROTEASE INHIBITOR, DI-NAG, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1z8g:A (CYS291) to (SER362) CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE TRANSMEMBRANE SERINE PROTEASE HEPSIN WITH COVALENTLY BOUND PREFERRED SUBSTRATE. | SERINE PROTEASE HEPSIN, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3liw:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH (R)-2-(1-ADAMANTYLCARBAMOYLAMINO)- 3-(3-CARBAMIDOYL-PHENYL)-N-PHENETHYL-PROPIONIC ACID AMIDE | COAGULATION FACTOR INHIBITOR, FACTOR XA, HYDROLASE, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, POLYMORPHISM, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN
1zhm:A (CYS136) to (HIS202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE COAGULATION FACTOR XIA IN COMPLEX WITH BENZAMIDINE (S434A- T475A-K437 MUTANT) | FACTOR XI; BENZAMIDINE, HYDROLASE, BLOOD CLOTTING
1zhr:A (THR134) to (HIS202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH BENZAMIDINE (S434A-T475A-C482S-K437A MUTANT) | FACTOR XI; BENZAMIDINE, HYDROLASE, BLOOD CLOTTING
4q2k:B (CYS136) to (LYS202) BOVINE ALPHA CHYMOTRYPSIN BOUND TO A CYCLIC PEPTIDE INHIBITOR, 5B | CHYMOTRYPSIN, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q2k:C (CYS136) to (ASN204) BOVINE ALPHA CHYMOTRYPSIN BOUND TO A CYCLIC PEPTIDE INHIBITOR, 5B | CHYMOTRYPSIN, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q2k:D (THR135) to (LYS202) BOVINE ALPHA CHYMOTRYPSIN BOUND TO A CYCLIC PEPTIDE INHIBITOR, 5B | CHYMOTRYPSIN, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zmn:A (THR134) to (ASN202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH (R)-1-(4-(4-(HYDROXYMETHYL)-1,3, 2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE | FXI, INHIBITOR, HYDROLASE
1zpc:A (CYS136) to (HIS202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH 2-[2-(3-CHLORO-PHENYL)-2-HYDROXY- ACETYLAMINO]-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]- 3-METHYL-BUTYRAMIDE | FXI, INHIBITOR, HYDROLASE
1zrk:A (CYS136) to (HIS202) FACTOR XI COMPLEXED WITH 3-HYDROXYPROPYL 3-(7- AMIDINONAPHTHALENE-1-CARBOXAMIDO)BENZENESULFONATE | SERINE PROTEASE, COAGULATION, HYDROLASE
1zsj:A (ASP135) to (LYS202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH N-(7-CARBAMIMIDOYL-NAPHTHALEN-1- YL)-3-HYDROXY-2-METHYL-BENZAMIDE | FXIA, INHIBITORS, HYDROLASE
1zsk:A (CYS136) to (HIS202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH 6-CARBAMIMIDOYL-4-(3-HYDROXY-2- METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER | FXIA, INHIBITORS, HYDROLASE
1zsl:A (THR134) to (HIS202) FACTOR XI COMPLEXED WITH A PYRIMIDINONE INHIBITOR | SERINE PROTEASE, COAGULATION, COVALENT COMPLEX, HYDROLASE
1ztk:A (THR134) to (ASN202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF COAGULATION FACTOR XI IN COMPLEX WITH 2-(5-AMINO-6-OXO-2-M-TOLYL-6H- PYRIMIDIN-1-YL)-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)- BUTYL]-ACETAMIDE | FXIA, INHIBITORS, HYDROLASE
5e2o:A (THR134) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[(N-{(2E)-3-[5-CHLORO-2- (1H-TETRAZOL-1-YL)PHENYL]PROP-2-ENOYL}-L-PHENYLALANYL)AMINO]BENZOIC ACID | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5e2p:A (THR134) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR N-[(1S)-1-BENZYL-2-[2-[5- CHLORO-2-(TETRAZOL-1-YL)PHENYL]ETHYLAMINO]-2-OXO-ETHYL]-4-HYDROXY-2- OXO-1H-QUINOLINE-6-CARBOXAMIDE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3lu9:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF HUMAN THROMBIN MUTANT S195A IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF HUMAN PAR1 | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PHARMACEUTICAL, POLYMORPHISM, PROTEASE, SECRETED, ZYMOGEN, CELL MEMBRANE, G-PROTEIN COUPLED RECEPTOR, MEMBRANE, PHOSPHOPROTEIN, RECEPTOR, TRANSDUCER, TRANSMEMBRANE
3atl:A (CYS134) to (SER202) CRYSTAL STRUCTURE OF TRYPSIN COMPLEXED WITH BENZAMIDINE | HYDROLASE, SERINE PROTEASE, PROTEIN, INHIBITOR, BOVINE PANCREAS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3atm:A (CYS134) to (SER202) CRYSTAL STRUCTURE OF TRYPSIN COMPLEXED WITH 2-(1H-INDOL-3-YL) ETHANAMINE | HYDROLASE, SERINE PROTEASE, PROTEIN, INHIBITOR, BOVINE PANCREAS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2a0q:B (TYR134) to (SER203) STRUCTURE OF THROMBIN IN 400 MM POTASSIUM CHLORIDE | SERINE PROTEASE, HYDROLASE
2a0q:D (TYR134) to (SER203) STRUCTURE OF THROMBIN IN 400 MM POTASSIUM CHLORIDE | SERINE PROTEASE, HYDROLASE
2a2x:H (TYR134) to (SER203) ORALLY ACTIVE THROMBIN INHIBITORS IN COMPLEX WITH THROMBIN INH12 | BLOOD CLOTTING, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2a31:A (GLU135) to (ASN202) TRYPSIN IN COMPLEX WITH BORATE | HYDROLASE, TRYPSIN
2a32:A (GLU135) to (CYS201) TRYPSIN IN COMPLEX WITH BENZENE BORONIC ACID | HYDROLASE
2a45:E (GLY136) to (LYS202) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THROMBIN AND THE CENTRAL "E" REGION OF FIBRIN | THROMBIN, FIBRIN, FRAGMENT E, THROMBIN-FIBRIN COMPLEX, COILED COILS, DISULFIDE RINGS, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3m36:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-[3-(AMINOMETHYL) PHENYL]-N-[3-FLUORO-2'-(METHYLSULFONYL)BIPHENYL-4-YL]-3- (TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE (DPC423) | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, POLYMORPHISM, PROTEASE, SECRETED, ZYMOGEN
3m37:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-[2-(AMINOMETHYL) PHENYL]-N-(3-FLUORO-2'-SULFAMOYLBIPHENYL-4-YL)-3- (TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE (DPC602) | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, POLYMORPHISM, PROTEASE, SECRETED, ZYMOGEN
4bah:B (TYR170) to (SER243) THROMBIN IN COMPLEX WITH INHIBITOR | HYDROLASE, SERINE PROTEASE, THROMBIN INHIBITOR
2aei:H (SER136) to (ARG204) CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF FACTOR VIIA/TISSUE FACTOR AND 2-[[6-[3-(AMINOIMINOMETHYL)PHENOXY]-3,5-DIFLURO-4-[(1-METHYL-3- PHENYLPROPYL)AMINO]-2-PYRIDINYL]OXY]-BENZOIC ACID | BLOOD COAGULATION, SERINE PROTEASE, THROMBOSIS, GLA, PYRIDINE, BENZAMIDINE, TISSUE FACTOR, COFACTOR, ENZYME INHIBITOR COMPLEX, HYDROLASE
3b9f:H (TYR134) to (PRO204) 1.6 A STRUCTURE OF THE PCI-THROMBIN-HEPARIN COMPLEX | MICHAELIS COMPLEX, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5eod:A (THR494) to (ASN566) HUMAN PLASMA COAGULATION FXI WITH PEPTIDE LP2 | HUMAN, PLASMA, COAGULATION FACTOR XI, COMPLEX, HYDROLASE
5eok:A (ASP495) to (HIS565) HUMAN PLASMA COAGULATION FACTOR XI IN COMPLEX WITH PEPTIDE P39 | HUMAN, PLASMA, COAGULATION FXI, COMPLEX, HYDROLASE
3bef:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF THROMBIN BOUND TO THE EXTRACELLULAR FRAGMENT OF PAR1 | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, SECRETED, ZYMOGEN, G-PROTEIN COUPLED RECEPTOR, MEMBRANE, PHOSPHOPROTEIN, RECEPTOR, TRANSDUCER, TRANSMEMBRANE
3bef:E (TYR134) to (SER203) CRYSTAL STRUCTURE OF THROMBIN BOUND TO THE EXTRACELLULAR FRAGMENT OF PAR1 | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, SECRETED, ZYMOGEN, G-PROTEIN COUPLED RECEPTOR, MEMBRANE, PHOSPHOPROTEIN, RECEPTOR, TRANSDUCER, TRANSMEMBRANE
3bg8:A (CYS496) to (HIS565) CRYSTAL STRUCTURE OF FACTOR XIA IN COMPLEX WITH CLAVATADINE A | PROTEASE INHIBITOR, FACTOR XIA INHIBITOR COMPLEX, COVALENT INHIBITOR, ALTERNATIVE SPLICING, BLOOD COAGULATION, DISEASE MUTATION, GLYCOPROTEIN, HEPARIN-BINDING, HYDROLASE, POLYMORPHISM, SECRETED, SERINE PROTEASE
5est:E (PRO135) to (LEU202) CRYSTALLOGRAPHIC ANALYSIS OF THE INHIBITION OF PORCINE PANCREATIC ELASTASE BY A PEPTIDYL BORONIC ACID: STRUCTURE OF A REACTION INTERMEDIATE | SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3biu:H (TYR134) to (SER203) HUMAN THROMBIN-IN COMPLEX WITH UB-THR10 | SERINE PROTEASE-INHIBITOR COMPLEX, BLOOD CLOTTING, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3biv:H (TYR134) to (SER203) HUMAN THROMBIN-IN COMPLEX WITH UB-THR11 | SERINE PROTEASE-INHIBITOR COMPLEX, BLOOD CLOTTING, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4boh:A (TYR454) to (SER533) MADANINS (MEROPS I53) ARE CLEAVED BY THROMBIN AND FACTOR XA | HYDROLASE-INHIBITOR COMPLEX, COAGULATION INHIBITOR, PROTEASE, MACROMOLECULAR RECOGNITION
3c27:B (TYR170) to (SER243) CYANOFLUOROPHENYLACETAMIDES AS ORALLY EFFICACIOUS THROMBIN INHIBITORS | THROMBIN, SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, ZYMOGEN, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, SULFATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4bxs:A (ASP300) to (THR368) CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS | BLOOD CLOTTING, BLOOD COAGULATION, PROTHROMBINASE, HYDROLASE
3nps:A (ILE136) to (GLU203) CRYSTAL STRUCTURE OF MEMBRANE-TYPE SERINE PROTEASE 1 (MT-SP1) IN COMPLEX WITH THE FAB INHIBITOR S4 | HYDROLASE, ANTIBODY-PROTEASE COMPLEX, PROTEIN-PROTEIN COMPLEX, ENZYME-INHIBITOR COMPLEX, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, SERINE PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, HYDROLASE - IMMUNE SYSTEM COMPLEX, HYDROLASE-IMMUNE SYSTEM COMPLEX
4cbn:B (CYS123) to (GLY190) CRYSTAL STRUCTURE OF COMPLEMENT FACTOR D MUTANT R202A AFTER CONVENTIONAL REFINEMENT | HYDROLASE, COMPLEMENT SYSTEM, ENSEMBLE REFINEMENT
4cbo:A (CYS123) to (CYS189) CRYSTAL STRUCTURE OF COMPLEMENT FACTOR D MUTANT R202A AFTER ENSEMBLE REFINEMENT | HYDROLASE, FACTOR D, ENSEMBLE REFINEMENT
4rko:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF THROMBIN MUTANT S195T BOUND WITH PPACK | TRYPSIN-LIKE PROTEASES, CATALYSIS, ALLOSTERIC REGULATION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3cs7:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(4-METHOXYPHENYL)- 6-(4-(1-(PYRROLIDIN-1-YLMETHYL)CYCLOPROPYL)PHENYL)-3- (TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, HYDROXYLATION, POLYMORPHISM, ZYMOGEN, BLOOD COAGULATION, CALCIUM, PROTEASE
4ch2:B (TYR454) to (SER533) LOW-SALT CRYSTAL STRUCTURE OF A THROMBIN-GPIBALPHA PEPTIDE COMPLEX | HYDROLASE-PEPTIDE COMPLEX
3d49:H (TYR134) to (SER203) THROMBIN INHIBITION | BLOOD CLOTTING/HYDROLASE INHIBITOR, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
4cr5:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4cr9:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4cra:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4crb:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4crc:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4crd:A (THR134) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4crf:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4crg:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
3dd2:H (TYR134) to (SER203) CRYSTAL STRUCTURE OF AN RNA APTAMER BOUND TO HUMAN THROMBIN | THROMBIN, APTAMER, RNA, DNA, HEPARIN, EXOSITE, PROTEASE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR-RNA COMPLEX
3dfl:A (CYS168) to (PRO245) CRYSTAL STRUCTURE OF HUMAN PROSTASIN COMPLEXED TO 4- GUANIDINOBENZOIC ACID | PROSTASIN, SERINE PROTEASE, GLYCOPROTEIN, HYDROLASE, MEMBRANE, SECRETED, TRANSMEMBRANE, ZYMOGEN
4ty6:A (CYS136) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-{2-[(1S)-1-({[TRANS-4- (AMINOMETHYL)CYCLOHEXYL]CARBONYL}AMINO)-2-PHENYLETHYL]-1H-IMIDAZOL-4- YL}BENZAMIDE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ty7:A (ASP135) to (HIS203) FACTOR XIA IN COMPLEX WITH THE INHIBITOR (2S)-6-AMINO-N-{(1S)-1-[4-(3- AMINO-2H-INDAZOL-6-YL)-5-CHLORO-1H-IMIDAZOL-2-YL]-2-PHENYLETHYL}-2- ETHYLHEXANAMIDE | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4d76:A (THR134) to (HIS202) HUMAN FXIA IN COMPLEX WITH SMALL MOLECULE INHIBITORS. | HYDROLASE, SERINE PROTEASE
4d7f:A (THR134) to (HIS202) HUMAN FXIA IN COMPLEX WITH SMALL MOLECULE INHIBITORS. | HYDROLASE, SERINE PROTEASE
4d8n:A (SER135) to (GLY202) HUMAN KALLIKREIN 6 INHIBITORS WITH A PARA-AMIDOBENZYLANMINE P1 GROUP CARRY A HIGH BINDING EFFICIENCY | HUMAN KALLIKREIN 6, HK6, SERINE PROTEASE, PROTEIN-LIGAND COMPLEX, AMIDINOTHIOPHENE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dt0:H (GLY136) to (PRO204) UNDERSTANDING THROMBIN INHIBITION | BLOOD CLOTTING, HYDROLASE INHIBITOR, ACUTE PHASE, BLOOD COAGULATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dux:H (TYR134) to (SER203) UNDERSTANDING THROMBIN INHIBITION | BLOOD CLOTTING, HYDROLASE INHIBITOR, ACUTE PHASE, BLOOD COAGULATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hcd:B (GLN570) to (ASN641) TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS MICROPLUS RACI2 | COMPLEMENT, INFLAMMATION, INHIBITOR, TICK, IMMUNE SYSTEM
4dih:H (TYR134) to (SER203) X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND THROMBIN BINDING APTAMER IN THE PRESENCE OF SODIUM IONS | PROTEIN-DNA COMPLEX, SERINE PROTEASE, BLOOD COAGULATION, APTAMER, HYDROLASE-HYDROLASE INHIBITOR-DNA COMPLEX, SERINE PROTEASE FOLD, DNA APTAMER, BLOOD, G-QUADRUPLEX
3pb1:E (CYS136) to (SER202) CRYSTAL STRUCTURE OF A MICHAELIS COMPLEX BETWEEN PLASMINOGEN ACTIVATOR INHIBITOR-1 AND UROKINASE-TYPE PLASMINOGEN ACTIVATOR | PAI-1, UPA, MICHAELIS COMPLEX, STRUCTURAL GENOMICS, STRUCTURE 2 FUNCTION PROJECT, S2F, HYDROLASE INHIBITOR-HYDROLASE COMPLEX
4ud9:H (TYR134) to (SER203) THROMBIN IN COMPLEX WITH 5-CHLOROTHIOPHENE-2-CARBOXAMIDE | HYDROLASE, HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, FRAGMENT, GLYCOSYLATION, BLOOD
4ue7:H (TYR134) to (SER203) THROMBIN IN COMPLEX WITH 1-AMIDINOPIPERIDINE | HYDROLASE, HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD
4dur:A (GLU679) to (LYS750) THE X-RAY CRYSTAL STRUCTURE OF FULL-LENGTH TYPE II HUMAN PLASMINOGEN | SERINE PROTEASE, FIBRINOLYSIS, HYDROLASE
4dur:B (GLU679) to (LYS750) THE X-RAY CRYSTAL STRUCTURE OF FULL-LENGTH TYPE II HUMAN PLASMINOGEN | SERINE PROTEASE, FIBRINOLYSIS, HYDROLASE
5i25:A (THR494) to (HIS565) HUMAN RECOMBINANT COAGULATION FXI IN COMPLEX WITH A PEPTIDE DERIVED FROM HUMAN HIGH MOLECULAR WEIGHT KININOGEN (HKP) | COAGULATION FXI, HIGH MOLECULAR WEIGHT KININOGEN, HYDROLASE
5i46:H (SER136) to (ARG204) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (2R,15R)-2-[(1- AMINOISOQUINOLIN-6-YL)AMINO]-8-FLUORO-7-HYDROXY-4,15,17-TRIMETHYL-13- OXA-4,11-DIAZATRICYCLO[14.2.2.1~6,10~]HENICOSA-1(18),6(21),7,9,16,19- HEXAENE-3,12-DIONE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4dy7:B (TYR134) to (SER203) CRYSTAL STRUCTURES OF PROTEASE NEXIN-1 IN COMPLEX WITH S195A THROMBIN | SERPIN, PROTEASE, HEPARIN, CELL SURFACE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pma:B (PHE134) to (PRO204) 2.2 ANGSTROM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN BOVINE THROMBIN AND SUCROSE OCTASULFATE | PROTEASE, THROMBOSIS, FIBRINOLYSIS, AGONIST, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pma:D (PHE134) to (SER203) 2.2 ANGSTROM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN BOVINE THROMBIN AND SUCROSE OCTASULFATE | PROTEASE, THROMBOSIS, FIBRINOLYSIS, AGONIST, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pmb:B (PHE134) to (LYS202) 2.9 ANGSTROM CRYSTAL STRUCTURE OF BOVINE THROMBIN IN TETRAGONAL SPACEGROUP | PROTEASE, THROMBOSIS, FIBRINOLOSYS, HYDROLASE
3pmb:D (PHE134) to (LYS202) 2.9 ANGSTROM CRYSTAL STRUCTURE OF BOVINE THROMBIN IN TETRAGONAL SPACEGROUP | PROTEASE, THROMBOSIS, FIBRINOLOSYS, HYDROLASE
4e7r:G (TYR1134) to (SER1203) THROMBIN IN COMPLEX WITH 3-AMIDINOPHENYLALANINE INHIBITOR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD
4f4o:C (GLY220) to (ASP304) STRUCTURE OF THE HAPTOGLOBIN-HAEMOGLOBIN COMPLEX | GLOBIN FOLD, SERINE PROTEASE FOLD, COMPLEMENT CONTROL PROTEIN, HAEMOGLOBIN SCAVENGING, OXYGEN STORAGE-TRANSPORT COMPLEX, OXYGEN TRANSPORT-TRANSPORT PROTEIN COMPLEX
4f4o:F (GLY220) to (ASP304) STRUCTURE OF THE HAPTOGLOBIN-HAEMOGLOBIN COMPLEX | GLOBIN FOLD, SERINE PROTEASE FOLD, COMPLEMENT CONTROL PROTEIN, HAEMOGLOBIN SCAVENGING, OXYGEN STORAGE-TRANSPORT COMPLEX, OXYGEN TRANSPORT-TRANSPORT PROTEIN COMPLEX
4f4o:I (GLY220) to (ASP304) STRUCTURE OF THE HAPTOGLOBIN-HAEMOGLOBIN COMPLEX | GLOBIN FOLD, SERINE PROTEASE FOLD, COMPLEMENT CONTROL PROTEIN, HAEMOGLOBIN SCAVENGING, OXYGEN STORAGE-TRANSPORT COMPLEX, OXYGEN TRANSPORT-TRANSPORT PROTEIN COMPLEX
4f4o:L (GLY220) to (ASP304) STRUCTURE OF THE HAPTOGLOBIN-HAEMOGLOBIN COMPLEX | GLOBIN FOLD, SERINE PROTEASE FOLD, COMPLEMENT CONTROL PROTEIN, HAEMOGLOBIN SCAVENGING, OXYGEN STORAGE-TRANSPORT COMPLEX, OXYGEN TRANSPORT-TRANSPORT PROTEIN COMPLEX
3qgn:B (TYR134) to (LYS202) THE ALLOSTERIC E*-E EQUILIBRIUM IS A KEY PROPERTY OF THE TRYPSIN FOLD | SERINE PROTEASE, HYDROLASE
3qlp:H (TYR134) to (SER203) X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND A MODIFIED THROMBIN BINDING APTAMER (MTBA) | PROTEIN-DNA COMPLEX, SERINE PROTEASE, BLOOD COAGULATION, APTAMER, SERINE PROTEASE FOLD, HYDROLASE-HYDROLASE INHIBITOR-DNA COMPLEX
3qto:H (TYR134) to (SER203) THROMBIN INHIBITION BY PYRIDIN DERIVATIVES | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qwc:H (TYR134) to (SER203) THROMBIN INHIBITION BY PYRIDIN DERIVATIVES | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3r3g:B (TYR134) to (SER203) STRUCTURE OF HUMAN THROMBIN WITH RESIDUES 145-150 OF MURINE THROMBIN. | SERINE PROTEASE, HYDROLASE
5jb8:S (GLY136) to (VAL203) CRYSTAL STRUCTURE OF FACTOR IXA VARIANT K98T IN COMPLEX WITH EGR- CHLOROMETHYLKETONE | BLOOD CLOTTING, HYDROLASE, GLYCOPROTEIN, HAEMOSTASIS
5jba:S (GLY136) to (GLU204) CRYSTAL STRUCTURE OF FACTOR IXA VARIANT V16I K98T Y177T I212V IN COMPLEX WITH PPACK | BLOOD CLOTTING, HYDROLASE, GLYCOPROTEIN, HAEMOSTASIS
5jbb:S (GLY136) to (VAL203) CRYSTAL STRUCTURE OF FACTOR IXA VARIANT V16I K98T Y177T I213V IN COMPLEX WITH EGR-CHLOROMETHYLKETONE | BLOOD CLOTTING, HYDROLASE, GLYCOPROTEIN, HAEMOSTASIS
5jbc:S (GLY136) to (VAL203) CRYSTAL STRUCTURE OF FACTOR IXA VARIANT V16I K98T Y177T I213V IN COMPLEX WITH PPACK | CRYSTAL STRUCTURE OF FACTOR IXA VARIANT K98T IN COMPLEX WITH EGR- CHLOROMETHYLKETONE, HYDROLASE
5jpm:J (ASP566) to (SER642) STRUCTURE OF THE COMPLEX OF HUMAN COMPLEMENT C4 WITH MASP-2 REBUILT USING IMDFF | COMPLEMENT, IMMUNE SYSTEM, BLOOD
5lpe:A (CYS136) to (CYS201) KALLIKREIN-RELATED PEPTIDASE 10 COMPLEX WITH ZN2+ | SERINE PROTEASE, ZYMOGEN-LIKE ENZYME, ZN2+ INHIBITION, TUMOR SUPPRESSOR, HYDROLASE
5lpe:B (GLN135) to (ASP202) KALLIKREIN-RELATED PEPTIDASE 10 COMPLEX WITH ZN2+ | SERINE PROTEASE, ZYMOGEN-LIKE ENZYME, ZN2+ INHIBITION, TUMOR SUPPRESSOR, HYDROLASE
5lpf:A (CYS136) to (ASP202) KALLIKREIN-RELATED PEPTIDASE 10 | SERINE PROTEASE, ZYMOGEN-LIKE ENZYME, ZN2+ INHIBITION, TUMOR SUPPRESSOR, HYDROLASE
5tca:A (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH3 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tca:B (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH3 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tca:C (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH3 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tca:D (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH3 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tca:E (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH3 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tca:F (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH3 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tcc:B (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH4 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tcc:C (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH4 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tcc:F (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH4 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5tcc:G (CYS138) to (GLY205) COMPLEMENT FACTOR D INHIBITED WITH JH4 | SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a0h:B (PHE454) to (PRO534) THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN | SERINE PROTEASE, COAGULATION, THROMBIN, PROTHROMBIN, MEIZOTHROMBIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ody:B (PHE134) to (SER203) THROMBIN-BOUND BOOPHILIN DISPLAYS A FUNCTIONAL AND ACCESSIBLE REACTIVE-SITE LOOP | KUNITZ-TYPE THROMBIN INHIBITOR, BLOOD CLOTTING-BLOOD CLOTTING INHIBITOR COMPLEX
2ody:D (PHE134) to (SER203) THROMBIN-BOUND BOOPHILIN DISPLAYS A FUNCTIONAL AND ACCESSIBLE REACTIVE-SITE LOOP | KUNITZ-TYPE THROMBIN INHIBITOR, BLOOD CLOTTING-BLOOD CLOTTING INHIBITOR COMPLEX
1abi:H (TYR134) to (SER203) STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS | HYDROLASE(SERINE PROTEINASE), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3edx:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE W215A/E217A MUTANT OF MURINE THROMBIN | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, ZYMOGEN
3edx:D (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE W215A/E217A MUTANT OF MURINE THROMBIN | SERINE PROTEASE, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, KRINGLE, PROTEASE, ZYMOGEN
2olg:A (GLN252) to (ALA324) CRYSTAL STRUCTURE OF THE SERINE PROTEASE DOMAIN OF PROPHENOLOXIDASE ACTIVATING FACTOR-I IN A ZYMOGEN FORM | PROPHENOLOXIDASE ACTIVATING FACTOR-I, PPAF-I, SERINE PROTEASE, HYDROLASE
1ae8:H (TYR134) to (SER203) HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP | COMPLEX (SERINE PROTEASE-INHIBITOR), BLOOD COAGULATION, N- ETHOXYCARBONYL-D-PHE-PRO-ALFA-AZALYS-P-NITROPHENYLESTER, SERINE PROTEINASE INHIBITION, GLYCOSYLATED PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1nu7:B (TYR134) to (SER203) STAPHYLOCOAGULASE-THROMBIN COMPLEX | THROMBIN NON-PROTEOLYTIC ACTIVATOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, PROTEIN BINDING
1ny2:2 (TYR134) to (PRO204) HUMAN ALPHA THROMBIN INHIBITED BY RPPGF AND HIRUGEN | THROMBOSIS, RETRO BINDING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bjv:A (CYS136) to (SER202) BETA-TRYPSIN COMPLEXED WITH APPU | HYDROLASE, SERINE PROTEASE, DIGESTION, PANCREAS, ZYMOGEN
1o3h:A (CYS136) to (SER202) ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE SITE-DIRECTED SERINE PROTEASE INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, INHIBITION MECHANISM, SHIFT OF PKA, TRYPSIN, THROMBIN, UROKINASE, FACTOR XA, HYDROLASE
1o3o:A (CYS136) to (SER202) ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATING BINDING OF ACTIVE SITE-DIRECTED SERINE PROTEASE INHIBITORS | SERINE PROTEASE, SHORT HYDROGEN BOND, INHIBITION MECHANISM, SHIFT OF PKA, TRYPSIN, THROMBIN, UROKINASE, FACTOR XA, HYDROLASE
3s7h:B (TYR134) to (SER203) STRUCTURE OF THROMBIN MUTANT Y225P IN THE E* FORM | SERINE PROTEASE, HYDROLASE
2bvx:H (GLY136) to (SER203) DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER | SERINE PROTEINASE, COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pr3:A (GLY136) to (LYS204) FACTOR XA INHIBITOR | FXA COAGULATION FACTOR INHIBITOR, BLOOD CLOTTING
3sor:A (THR512) to (ASN584) FACTOR XIA IN COMPLEX WITH A CLOROPHENYL-TETRAZOLE INHIBITOR | HYDROLASE, SERINE PROTEASE, COAGULATION FACTOR, SYNTETHIC INHIBITOR, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4igd:A (VAL584) to (ARG655) CRYSTAL STRUCTURE OF THE ZYMOGEN CATALYTIC REGION OF HUMAN MASP-1 | COMPLEMENT, IMMUNE RESPONSE, INNATE IMMUNITY, BETA BARREL, HYDROLASE, SERINE PROTEASE, GLYCOSYLATION
1p2o:A (THR135) to (LYS202) STRUCTURAL CONSEQUENCES OF ACCOMMODATION OF FOUR NON- COGNATE AMINO-ACID RESIDUES IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN | TRYPSIN; CHYMOTRYPSIN; SERINE PROTEINASE; BOVINE PANCREATIC TRYPSIN INHIBITOR; PROTEIN-PROTEIN INTERACTION; NON-COGNATE BINDING; S1 POCKET; PRIMARY SPECIFICITY; CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1p2o:C (THR135) to (LYS202) STRUCTURAL CONSEQUENCES OF ACCOMMODATION OF FOUR NON- COGNATE AMINO-ACID RESIDUES IN THE S1 POCKET OF BOVINE TRYPSIN AND CHYMOTRYPSIN | TRYPSIN; CHYMOTRYPSIN; SERINE PROTEINASE; BOVINE PANCREATIC TRYPSIN INHIBITOR; PROTEIN-PROTEIN INTERACTION; NON-COGNATE BINDING; S1 POCKET; PRIMARY SPECIFICITY; CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
4iw4:F (GLY569) to (ASP654) CRYSTAL STRUCTURE OF THE SERINE PROTEASE DOMAIN OF MASP-3 IN COMPLEX WITH ECOTIN | TRYPSIN-LIKE FOLD, PROTEASE, INHIBITOR, EXTRACELLULAR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4j1y:B (ASP563) to (GLN639) THE X-RAY CRYSTAL STRUCTURE OF HUMAN COMPLEMENT PROTEASE C1S ZYMOGEN | C4, C2, HYDROLYSIS, EXTRACELLULAR, HYDROLASE
1q8m:A (ALA21) to (LEU67) CRYSTAL STRUCTURE OF THE HUMAN MYELOID CELL ACTIVATING RECEPTOR TREM-1 | V-TYPE IG-LIKE DOMAIN, IMMUNOGLOBULIN-LIKE, IMMUNE SYSTEM RECEPTOR
2ra0:A (GLY136) to (PHE203) X-RAY STRUCTURE OF FXA IN COMPLEX WITH 7-FLUOROINDAZOLE | SERINE PROTEASE, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROLASE, HYDROXYLATION, POLYMORPHISM, ZYMOGEN
1ezq:A (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515 | HYDROLASE
2uuf:B (TYR134) to (SER203) THROMBIN-HIRUGEN BINARY COMPLEX AT 1.26A RESOLUTION | SERINE PROTEASE INHIBITOR, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, SERINE PROTEASE, THROMBIN, PROTEASE, SULFATION, ACUTE PHASE, HIGH RESOLUTION, DISEASE MUTATION, SERINE PROTEINASE, BLOOD COAGULATION, PROTEASE INHIBITOR, BLOOD CLOTTING, CLEAVAGE ON PAIR OF BASIC RESIDUES, HIRUGEN, KRINGLE, ZYMOGEN, SECRETED, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jzf:H (SER136) to (ARG204) STRUCTURE OF FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 2-{2-[(3- CARBAMOYLPHENYL)CARBAMOYL]-6-METHOXYPYRIDIN-3-YL}-5-{[(2S)-1-HYDROXY- 3,3-DIMETHYLBUTAN-2-YL]CARBAMOYL}BENZOIC ACID | GLYCOPROTEIN, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uir:B (GLU679) to (LYS750) CRYSTAL STRUCTURE OF THE PLASMIN-TEXTILININ-1 COMPLEX | SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1rjx:B (GLU679) to (LYS750) HUMAN PLASMINOGEN CATALYTIC DOMAIN, K698M MUTANT | MICROPLASMINOGEN, PLASMINOGEN ACTIVATION, STREPTOKINASE, HYDROLASE
2vh0:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: BIARYL PYRROLIDIN-2-ONES INCORPORATING BASIC HETEROCYCLIC MOTIFS | SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, GAMMA-CARBOXYGLUTAMIC ACID, CALCIUM, ZYMOGEN, COMPLEX, PROTEASE, HYDROLASE, CLEAVAGE ON PAIR OF BASIC RESIDUES
1s09:A (GLU36) to (ALA86) CRYSTAL STRUCTURE OF THE Y144F MUTANT OF 7,8- DIAMINOPELARGONIC ACID SYNTHASE | AMINOTRANSFERASE, FOLD TYPE I, SUBCLASS II, HOMODIMER
3hpt:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH (S)-2-CYANO-1-(2- METHYLBENZOFURAN-5-YL)-3-(2-OXO-1-(2-OXO-2-(PYRROLIDIN-1-YL)ETHYL) AZEPAN-3-YL)GUANIDINE | SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF- LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING, BLOOD COAGULATION, DISULFIDE BOND, PROTEASE, SECRETED
3hpt:D (GLY136) to (PHE203) CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH (S)-2-CYANO-1-(2- METHYLBENZOFURAN-5-YL)-3-(2-OXO-1-(2-OXO-2-(PYRROLIDIN-1-YL)ETHYL) AZEPAN-3-YL)GUANIDINE | SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF- LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING, BLOOD COAGULATION, DISULFIDE BOND, PROTEASE, SECRETED
2flr:H (SER136) to (ARG204) NOVEL 5-AZAINDOLE FACTOR VIIA INHIBITORS | SHORT HYDROGEN BOND, 5-AZAINDOLE INHIBITORS, S1 SITE, HYDROLASE/BLOOD CLOTTING COMPLEX
4zae:A (GLY136) to (GLU204) DEVELOPMENT OF A NOVEL CLASS OF POTENT AND SELECTIVE FIXA INHIBITORS | SERINE PROTEINASE, BLOOD COAGULATION, COAGULATION FACTOR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1gi9:B (CYS136) to (SER202) A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE | THREE-CENTERED, VERY SHORT HYDROGEN BOND, OXYANION HOLE WATER, SHIFT OF PKA OF HIS57, STRUCTURE-BASED DRUG DESIGN, SPECIFICITY, UROKINASE, TRYPSIN, THROMBIN, ZN+2-MEDIATED INHIBITION, BLOOD CLOTTING, HYDROLASE
1sg8:B (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE PROCOAGULANT FAST FORM OF THROMBIN | THROMBIN, ALLOSTERY, HYDROLASE
1sg8:E (TYR134) to (SER203) CRYSTAL STRUCTURE OF THE PROCOAGULANT FAST FORM OF THROMBIN | THROMBIN, ALLOSTERY, HYDROLASE
2vnt:A (CYS144) to (SER214) UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7-SULPHOAMIDOISOQUINOLINYL)GUANIDINE | UPA, INHIBITOR COMPLEX, HYDROLASE
2vnt:B (CYS144) to (SER214) UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7-SULPHOAMIDOISOQUINOLINYL)GUANIDINE | UPA, INHIBITOR COMPLEX, HYDROLASE
2vnt:C (CYS144) to (SER214) UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7-SULPHOAMIDOISOQUINOLINYL)GUANIDINE | UPA, INHIBITOR COMPLEX, HYDROLASE
2vnt:D (CYS144) to (SER214) UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7-SULPHOAMIDOISOQUINOLINYL)GUANIDINE | UPA, INHIBITOR COMPLEX, HYDROLASE
2vnt:E (CYS144) to (SER214) UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7-SULPHOAMIDOISOQUINOLINYL)GUANIDINE | UPA, INHIBITOR COMPLEX, HYDROLASE
2vnt:F (CYS144) to (SER214) UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7-SULPHOAMIDOISOQUINOLINYL)GUANIDINE | UPA, INHIBITOR COMPLEX, HYDROLASE
2vwo:A (GLY136) to (PHE203) AMINOPYRROLIDINE FACTOR XA INHIBITOR | HYDROLASE, CATION, PLASMA, CALCIUM, ZYMOGEN, PROTEASE, INHIBITOR, POLYMORPHISM, GLYCOPROTEIN, GAMMA-CARBOXYGLUTAMIC ACID, BLOOD CLOTTING, COAGULATION FACTOR, HYDROXYLATION, SERINE PROTEASE, EGF-LIKE DOMAIN, CLEAVAGE ON PAIR OF BASIC RESIDUES
4zj6:A (THR134) to (HIS203) THE CRYSTAL STRUCTURE OF HUMAN PLASMA KALLIKREIN IN COMPLEX WITH ITS PEPTIDE INHIBITOR PKALIN-3 | PEPTIDE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2w26:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH BAY59-7939 | SERINE PROTEASE, EGF-LIKE DOMAIN, BLOOD COAGULATION, GAMMA-CARBOXYGLUTAMIC ACID, HYDROLASE, POLYMORPHISM, GLYCOPROTEIN, HYDROXYLATION, CALCIUM, ZYMOGEN, PROTEASE, SECRETED, FACTOR XA, CLEAVAGE ON PAIR OF BASIC RESIDUES
1t8n:A (THR135) to (LYS202) CRYSTAL STRUCTURE OF THE P1 THR BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | CHYMOTRYPSIN, SERINE PROTEINASE, BOVINE PANCREATIC TRYPSIN INHIBITOR, BPTI, PROTEIN-PROTEIN INTERACTION, NON-COGNATE BINDING, S1 POCKET, PRIMARY SPECIFICITY, CRYSTAL STRUCTURE, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1tgt:A (CYS136) to (SER202) ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY | HYDROLASE ZYMOGEN (SERINE PROTEINASE)
1toc:B (PHE134) to (SER203) STRUCTURE OF SERINE PROTEINASE | VITAMIN K, ZYMOGEN, GAMMA-CARBOXYGLUTAMIC ACID, ACUTE PHASE, LIVER, HYDROLASE, SERINE PROTEASE KUNITZ-LIKE INHIBITOR, KRINGLE, SIGNAL, COMPLEX (HYDROLASE/INHIBITOR) COMPLEX
1toc:D (GLY136) to (SER203) STRUCTURE OF SERINE PROTEINASE | VITAMIN K, ZYMOGEN, GAMMA-CARBOXYGLUTAMIC ACID, ACUTE PHASE, LIVER, HYDROLASE, SERINE PROTEASE KUNITZ-LIKE INHIBITOR, KRINGLE, SIGNAL, COMPLEX (HYDROLASE/INHIBITOR) COMPLEX
1toc:F (GLY136) to (SER203) STRUCTURE OF SERINE PROTEINASE | VITAMIN K, ZYMOGEN, GAMMA-CARBOXYGLUTAMIC ACID, ACUTE PHASE, LIVER, HYDROLASE, SERINE PROTEASE KUNITZ-LIKE INHIBITOR, KRINGLE, SIGNAL, COMPLEX (HYDROLASE/INHIBITOR) COMPLEX
1toc:H (GLY136) to (SER203) STRUCTURE OF SERINE PROTEINASE | VITAMIN K, ZYMOGEN, GAMMA-CARBOXYGLUTAMIC ACID, ACUTE PHASE, LIVER, HYDROLASE, SERINE PROTEASE KUNITZ-LIKE INHIBITOR, KRINGLE, SIGNAL, COMPLEX (HYDROLASE/INHIBITOR) COMPLEX
1tpa:E (CYS136) to (SER202) THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | COMPLEX (PROTEINASE/INHIBITOR)
1hrt:H (GLY136) to (PRO204) THE STRUCTURE OF A COMPLEX OF BOVINE ALPHA-THROMBIN AND RECOMBINANT HIRUDIN AT 2.8 ANGSTROMS RESOLUTION | HYDROLASE(SERINE PROTEINASE)
1hyl:A (ALA136) to (LEU201) THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM | HYDROLASE (SERINE PROTEASE)
1hyl:B (ALA136) to (LEU201) THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM | HYDROLASE (SERINE PROTEASE)
4loy:H (TYR134) to (SER203) CRYSTAL STRUCTURE ANALYSIS OF THROMBIN IN COMPLEX WITH COMPOUND D57, 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID [(S)-2-[2-METHYL-3-(2- OXOPYRROLIDIN-1-YL)BENZENESULFONYLAMINO]-3-(4-METHYLPIPERAZIN-1- YL)- 3-OXOPROPYL]AMIDE (SAR107375) | SERINE PROTEASES, DUAL THROMBIN/FACTOR XA INHIBITION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1u6q:A (CYS134) to (SER204) SUBSTITUTED 2-NAPHTHAMADINE INHIBITORS OF UROKINASE | HYDROLASE
1id5:H (PHE134) to (PRO204) CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEX WITH PROTEASE INHIBITOR ECOTIN | THROMBIN, ECOTIN M84R, CONFORMATIONAL CHANGES, HYDROLASE
1iqj:A (GLY136) to (LYS204) HUMAN COAGULATION FACTOR XA IN COMPLEX WITH M55124 | HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, COMPLEX
2xc0:A (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR | BLOOD CLOTTING, COAGULATION FACTOR, HYDROLASE, HYDROXYLATION, SERINE PROTEASE, ZYMOGEN
4mpx:A (PRO154) to (LYS231) HUMAN BETA-TRYPTASE CO-CRYSTAL STRUCTURE WITH [(1,1,3,3- TETRAMETHYLDISILOXANE-1,3-DIYL)DI-1-BENZOTHIENE-4,2-DIYL]BIS({4-[3- (AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE) | COFERON, ALPHA-HYDROXYKETONE, SMALL MOLECULE INHIBITOR, DRUG DISCOVERY, SELF-ASSEMBLY, CRYSTAL CATALYSIS, SILANOL, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1vit:H (GLY136) to (SER203) THROMBIN:HIRUDIN 51-65 COMPLEX | COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION, COMPLEX (SERINE PROTEASE-INHIBITOR) COMPLEX
2y6t:A (THR135) to (LYS202) MOLECULAR RECOGNITION OF CHYMOTRYPSIN BY THE SERINE PROTEASE INHIBITOR ECOTIN FROM YERSINIA PESTIS | HYDROLASE-INHIBITOR COMPLEX
2y6t:B (THR135) to (ASN204) MOLECULAR RECOGNITION OF CHYMOTRYPSIN BY THE SERINE PROTEASE INHIBITOR ECOTIN FROM YERSINIA PESTIS | HYDROLASE-INHIBITOR COMPLEX
2y6t:C (THR135) to (LYS202) MOLECULAR RECOGNITION OF CHYMOTRYPSIN BY THE SERINE PROTEASE INHIBITOR ECOTIN FROM YERSINIA PESTIS | HYDROLASE-INHIBITOR COMPLEX
2y6t:D (THR135) to (LYS203) MOLECULAR RECOGNITION OF CHYMOTRYPSIN BY THE SERINE PROTEASE INHIBITOR ECOTIN FROM YERSINIA PESTIS | HYDROLASE-INHIBITOR COMPLEX
2y82:A (GLY136) to (PHE203) STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS | BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION
1lpk:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125. | PROTEIN INHIBITOR COMPLEX, BLOOD COAGULATION FACTOR, SERINE PROTEINASE, HYDROLASE
1lpz:B (GLY136) to (PHE203) CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41. | PROTEIN INHIBITOR COMPLEX, BLOOD COAGULATION FACTOR, SERINE PROTEINASE, HYDROLASE
1xka:C (GLY136) to (PHE203) FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'- AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID | BLOOD COAGULATION FACTOR, SERINE PROTEINASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN
2zg0:H (TYR134) to (SER203) EXPLORING THROMBIN S3 POCKET | BLOOD COAGULATION/HYDROLASE INHIBITORS, ACUTE PHASE, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, ZYMOGEN, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, SULFATION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2zgc:A (ARG119) to (GLY189) CRYSTAL STRUCTURE OF ACTIVE HUMAN GRANZYME M | SERINE PROTEASE, CYTOLYSIS, GLYCOPROTEIN, HYDROLASE, SECRETED, ZYMOGEN
2zi2:H (TYR134) to (SER203) THROMBIN INHIBITION | BLOOD CLOTTING, HYDROLASE INHIBITORS, ACUTE PHASE, BLOOD COAGULATION, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, KRINGLE, PROTEASE, SECRETED, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1m9u:A (CYS136) to (ASN192) CRYSTAL STRUCTURE OF EARTHWORM FIBRINOLYTIC ENZYME COMPONENT A FROM EISENIA FETIDA | HYDROLASE, SERINE PROTEASE (ELASTASE-LIKE), FIBRINOLYTIC ENZYME
1m9u:B (CYS136) to (ASN192) CRYSTAL STRUCTURE OF EARTHWORM FIBRINOLYTIC ENZYME COMPONENT A FROM EISENIA FETIDA | HYDROLASE, SERINE PROTEASE (ELASTASE-LIKE), FIBRINOLYTIC ENZYME
1m9u:C (CYS136) to (ASN192) CRYSTAL STRUCTURE OF EARTHWORM FIBRINOLYTIC ENZYME COMPONENT A FROM EISENIA FETIDA | HYDROLASE, SERINE PROTEASE (ELASTASE-LIKE), FIBRINOLYTIC ENZYME
1mkw:H (PHE134) to (PRO204) THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA- THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING | COMPLEX (BLOOD COAGULATION/PROENZYME), THROMBIN, PRETHROMBIN-2, PLASMA, SERINE PROTEASE
1ypm:H (TYR134) to (SER203) X-RAY CRYSTAL STRUCTURE OF THROMBIN INHIBITED BY SYNTHETIC CYANOPEPTIDE ANALOGUE RA-1014 | THROMBIN, INHIBITOR COMPLEX, BARREL, 6 STRANDED BETA-SHEET, BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX
3lc5:A (GLY136) to (VAL203) SELECTIVE BENZOTHIOPHINE INHIBITORS OF FACTOR IXA | PROTEIN-INHIBITOR COMPLEX, PEPTIDASE S1, BLOOD COAGULATION, CALCIUM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, DISULFIDE BOND, EGF-LIKE DOMAIN, GAMMA- CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HEMOPHILIA, HYDROLASE, HYDROXYLATION, PHARMACEUTICAL, PHOSPHOPROTEIN, POLYMORPHISM, PROTEASE, SECRETED, SERINE PROTEASE, SULFATION, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zlr:A (CYS136) to (HIS202) FACTOR XI CATALYTIC DOMAIN COMPLEXED WITH 2-GUANIDINO-1-(4-(4,4,5,5- TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)ETHYL NICOTINATE | SERINE PROTEASE, BORON, COVALENT INHIBITOR, HYDROLASE
5egm:A (GLY136) to (GLU204) DEVELOPMENT OF A NOVEL TRICYCLIC CLASS OF POTENT AND SELECTIVE FIXA INHIBITORS | SERINE PROTEINASE, BLOOD COAGULATION, COAGULATION FACTOR, HYDROLASE-2 HYDROLASE INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4bti:B (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE DUAL THROMBIN-FXA INHIBITOR 58. | HYDROLASE, SAR107375, FACTOR XA INHIBITOR, THROMBIN INHIBITOR, CHLOROTHIOPHENE P1 FRAGMENT, S3 SUBSITE, MICROSOMES STABILITY, ORAL ANTITHROMBOTIC, DUAL INHIBITOR, IV ANTITHROMBOTIC
4bti:F (GLY136) to (PHE203) FACTOR XA IN COMPLEX WITH THE DUAL THROMBIN-FXA INHIBITOR 58. | HYDROLASE, SAR107375, FACTOR XA INHIBITOR, THROMBIN INHIBITOR, CHLOROTHIOPHENE P1 FRAGMENT, S3 SUBSITE, MICROSOMES STABILITY, ORAL ANTITHROMBOTIC, DUAL INHIBITOR, IV ANTITHROMBOTIC
3cen:A (GLY136) to (LYS204) FACTOR XA IN COMPLEX WITH THE INHIBITOR N-(2-(((5-CHLORO-2- PYRIDINYL) AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)- PYRIDINYL)BENZAMIDE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, HYDROXYLATION, POLYMORPHISM, ZYMOGEN
4cre:A (CYS136) to (HIS202) CREATING NOVEL F1 INHIBITORS THROUGH FRAGMENT BASED LEAD GENERATION AND STRUCTURE AIDED DRUG DESIGN | HYDROLASE
4thn:H (TYR134) to (SER203) THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN-HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE. | COMPLEX (SERINE PROTEASE-INHIBITOR), THROMBIN SYNTHETIC INHIBITORS, ANTITHROMBOTICS, HIRUDIN-LIKE BINDING MODE, HIRUNORMS, THROMBIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5gds:H (TYR134) to (SER203) HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX | SERINE PROTEASE-INHIBITOR COMPLEX, THROMBIN, THROMBIN SYNTHETIC INHIBITORS, ANTITHROMBOTICS, HIRUNORMS, HIRUDIN-LIKE BINDING MODE, BLOOD COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3p70:F (TYR497) to (SER576) STRUCTURAL BASIS OF THROMBIN-MEDIATED FACTOR V ACTIVATION: ESSENTIAL ROLE OF THE HIRUDIN-LIKE SEQUENCE GLU666-GLU672 FOR PROCESSING AT THE HEAVY CHAIN-B DOMAIN JUNCTION | TRYPSIN-LIKE SERINE PROTEINASE, BLOOD COAGULATION, N-GLYCOSYLATION, BLOOD PLASMA, HYDROLASE
3p70:H (TYR497) to (PRO577) STRUCTURAL BASIS OF THROMBIN-MEDIATED FACTOR V ACTIVATION: ESSENTIAL ROLE OF THE HIRUDIN-LIKE SEQUENCE GLU666-GLU672 FOR PROCESSING AT THE HEAVY CHAIN-B DOMAIN JUNCTION | TRYPSIN-LIKE SERINE PROTEINASE, BLOOD COAGULATION, N-GLYCOSYLATION, BLOOD PLASMA, HYDROLASE
3qdz:D (TYR134) to (PRO204) CRYSTAL STRUCTURE OF THE HUMAN THROMBIN MUTANT D102N IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF HUMAN PAR4. | SERINE PROTEASE, PROTEIN FUNCTION, PROTEASE-ACTIVATED RECEPTORS, HYDROLASE-HYDROLASE RECEPTOR COMPLEX
3qx5:H (TYR134) to (SER203) THROMBIN INHIBITION BY PYRIDIN DERIVATIVES | SERINE PROTEASE, KRINGLE, HYDROLASE, BLOOD COAGULATION, BLOOD CLOTTING, CONVERTION OF FIBRINOGEN TO FIBRIN, CLEAVAGE ON PAIRS OF BASIC RESIDUES, BLOOD CLOTTING INHIBITOR, THROMBIN INHIBITOR, GLYCOSYLATION, BLOOD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5jb9:S (GLY136) to (GLU204) CRYSTAL STRUCTURE OF FACTOR IXA K98T VARIANT IN COMPLEX WITH PPACK | BLOOD CLOTTING, HYDROLASE, GLYCOPROTEIN, HAEMOSTASIS
5k0h:A (GLY136) to (PHE203) HUMAN FACTOR XA IN COMPLEX WITH SYNTHETIC INHIBITOR BENZYLSULFONYL- DSER(BENZYL)-GLY-4-AMIDINOBENZYLAMIDE | HUMAN FACTOR XA, INHIBITOR COMPLEX, BENZAMIDINE INHIBITOR, HYDROLASE, CLOTTING FACTOR
5l30:H (SER136) to (ARG204) FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (2R,15R)-2-[(1- AMINOISOQUINOLIN-6-YL)AMINO]-4,15,17-TRIMETHYL-7-[1-(1H-TETRAZOL-5- YL)CYCLOPROPYL]-13-OXA-4,11-DIAZATRICYCLO[14.2.2.1~6,10~]HENICOSA- 1(18),6(21),7,9,16,19-HEXAENE-3,12-DIONE | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX