Usages in wwPDB of concept: c_0781
nUsages: 523; SSE string: EHEHE
3ro9:A     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3ro9:B     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3roa:A     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-[(3R)-3-[3-METHOXY-5-(MORPHOLIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1004)  |   ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
2anq:A     (MET1) to    (SER63)  CRYSTAL STRUCTURE OF E.COLI DHFR IN COMPLEX WITH NADPH AND THE INHIBITOR COMPOUND 10A.  |   DHFR, PROTEIN INHIBITOR COMPLEX, OXIDOREDUCTASE 
2oip:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:B     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:C     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:D     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:E     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
3eel:A     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH 2,4-DIAMINO-5- [3-METHYL-3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL)PHENYL)PROP-1-YNYL]-6- METHYLPYRIMIDINE(UCP11153TM) AND NADPH  |   ENZYME, OXIDOREDUCTASE 
3eem:B     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH 2,4-DIAMINO-5- [3-METHYL-3-(3-METHOXY-5-(2,6-DIMETHYLPHENYL)PHENYL)PROP-1-YNYL]-6- METHYLPYRIMIDINE(UCP111D26M) AND NADPH  |   ENZYME, OXIDOREDUCTASE 
1ao8:A     (THR1) to    (THR63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES  |   OXIDOREDUCTASE, INHIBITOR/ENZYME COMPLEX 
2b3z:D   (TYR147) to   (VAL222)  CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS  |   ALPHA/BETA/ALPHA, DEAMINASE DOMAIN AND REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE 
4h95:A     (VAL6) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-{3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL}PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4h95:B    (LEU17) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-{3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL}PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4h97:A    (LEU17) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-METHOXY-5-(4-METHYLPHENYL)PHENYL]BUT-1-YN-1-YL}-6- METHYLPYRIMIDINE-2,4-DIAMINE (UCP111D4M)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4h97:B     (VAL6) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-METHOXY-5-(4-METHYLPHENYL)PHENYL]BUT-1-YN-1-YL}-6- METHYLPYRIMIDINE-2,4-DIAMINE (UCP111D4M)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4h98:A     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018)  |   ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4h98:B     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018)  |   ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
2oz5:A    (ARG26) to    (PRO81)  CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEIN TYROSINE PHOSPHATASE PTPB IN COMPLEX WITH THE SPECIFIC INHIBITOR OMTS  |   PROTEIN TYROSINE PHOSPHATASE IN COMPLEX WITH SMALL MOLECULE INHIBITOR, STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, UNKNOWN FUNCTION 
4ha9:A    (VAL32) to   (ILE105)  STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7  |   REDUCTASE, NADPH BINDING, OXIDOREDUCTASE 
3ex8:C   (TYR147) to   (THR221)  COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS  |   ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE 
3ex8:D   (VAL148) to   (LEU219)  COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS  |   ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE 
3s3v:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE Q35K/N64F DOUBLE MUTANT BINARY COMPLEX WITH TRIMETHOPRIM  |   NOVEL SECOND BINDING SITE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3f0b:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-PHENYLPHENYL)BUT-1-YNYL]-6- METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
3f0s:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL)PHENYL)BUT-1-YNYL]- 6-METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
3f0u:X     (THR1) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-PHENYLPHENYL)BUT-1- YNYL]-6-METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
4x5f:A    (ILE14) to    (LEU62)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 0.1 MPA  |   OXIDOREDUCTASE 
4x5f:B    (ILE14) to    (SER63)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 0.1 MPA  |   OXIDOREDUCTASE 
4x5g:A    (ILE14) to    (LEU62)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 270 MPA  |   OXIDOREDUCTASE 
4x5g:B    (ILE14) to    (SER63)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 270 MPA  |   OXIDOREDUCTASE 
4x5h:A    (ILE14) to    (LEU62)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 500 MPA  |   OXIDOREDUCTASE 
4x5i:A    (ILE14) to    (LEU62)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 660 MPA  |   OXIDOREDUCTASE 
1boz:A     (LEU4) to    (SER76)  STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4- DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS  |   OXIDOREDUCTASE 
4hog:B     (VAL6) to    (SER78)  CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- [3-(2-METHOXY-4-PHENYLPHENYL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4- DIAMINE (UCP111H)  |   ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3f8z:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE STRUCTURAL DATA WITH ACTIVE SITE MUTANT ENZYME COMPLEXES  |   ACTIVE SITE MUTANTS LIGAND COMPLEX HUMAN DIHYDROFOLATE REDUCTASE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
3s9u:A     (ARG2) to    (THR64)  BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP120J  |   OXIDOREDUCTASE 
3sa1:B     (VAL3) to    (THR64)  BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1021  |   OXIDOREDUCTASE 
3sa2:A     (VAL3) to    (THR64)  BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1014  |   OXIDOREDUCTASE 
3sa2:B     (VAL3) to    (THR64)  BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1014  |   OXIDOREDUCTASE 
3saf:B   (GLU336) to   (ASP388)  CRYSTAL STRUCTURE OF THE HUMAN RRP6 CATALYTIC DOMAIN WITH D313N MUTATION IN THE ACTIVE SITE  |   EXORIBONUCLEASE, RNA EXOSOME, HYDROLASE 
3sai:A     (ARG2) to    (THR64)  BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP1015  |   OXIDOREDUCTASE 
3sai:B     (VAL3) to    (THR64)  BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP1015  |   OXIDOREDUCTASE 
1bzf:A     (THR1) to    (THR63)  NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES  |   OXIDOREDUCTASE, INHIBITOR/ENZYME COMPLEX 
4xe6:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1061)  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4xec:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1061)  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4i1n:A     (MET1) to    (SER63)  R104A-CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX  |   ALPHA/BETA FOLD, IMMUNOGLOBULIN FOLD, REDUCTASE, NADPH, FOLATE DERIVATIVES, HYDRIDE TRANSFER, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
1ohk:A    (ILE16) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM  |   OXIDOREDUCTASE 
3sh2:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(4-METHOXYBIPHENYL-3-YL)PROP-1-YNYL)PYRIMIDINE-2,4- DIAMINE (UCP120J)  |   OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3sh2:B     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(4-METHOXYBIPHENYL-3-YL)PROP-1-YNYL)PYRIMIDINE-2,4- DIAMINE (UCP120J)  |   OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
2c2s:A     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4- DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, A NOVEL BORON CONTAINING, NONCLASSICAL ANTIFOLATE  |   NONCLASSICAL ANTIFOLATES, LIPOPHILIC ANTIFOLATES, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE, REDUCTASE 
2c2t:A     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4- DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6- METHYLPYRIMIDINE, A NOVEL BORON CONTAINING, NONCLASSICAL ANTIFOLATE  |   NONCLASSICAL ANTIFOLATES, LIPOPHILIC ANTIFOLATES, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE, REDUCTASE 
3fl8:A     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:B     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:C     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:D     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:E     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:F     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:G     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl8:H     (VAL3) to    (ARG65)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:A     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:B     (VAL3) to    (ARG65)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:C     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:D     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:E     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:F     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:G     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fl9:H    (ARG13) to    (THR64)  CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE 
3fq0:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B)  |   OXIDOREDUCTASE 
3fqc:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]-6- METHYLPYRIMIDINE (UCP115A)  |   OXIDOREDUCTASE 
3fqc:B     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]-6- METHYLPYRIMIDINE (UCP115A)  |   OXIDOREDUCTASE 
3fqf:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]- 6-METHYLPYRIMIDINE (UCP115A)  |   OXIDOREDUCTASE 
3fqz:A    (ILE14) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-4-PHENYLPHENYL)BUT-1-YNYL]-6- METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
3frb:X     (LEU2) to    (THR63)  S. AUREUS F98Y DHFR COMPLEXED WITH TMP  |   S. AUREUS DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3frd:X     (LEU2) to    (THR63)  S. AUREUS DHFR COMPLEXED WITH NADPH AND FOLATE  |   S AUREUS DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3fre:X     (THR1) to    (THR63)  S. AUREUS DHFR COMPLEXED WITH NADPH AND TMP  |   DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3frf:X     (THR1) to    (THR63)  S. AUREUS DHFR COMPLEXED WITH NADPH AND ICLAPRIM  |   DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3sqy:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3sr5:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3srq:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3srr:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3srs:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3sru:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3srw:X     (LEU3) to    (THR64)  S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES  |   DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3fy9:X     (LEU2) to    (THR63)  STAPH. AUREUS DHFR F98Y COMPLEXED WITH AR-102  |   DHFR, AR-102, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3fy8:X     (LEU2) to    (THR63)  CRYSTAL STRUCTURE OF STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR- 101  |   DHFR, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
3fyv:X     (LEU2) to    (THR63)  STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR-102  |   DHFR, STAPH.AUREUS, AR-102, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3fyw:X     (LEU2) to    (THR63)  STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR-101  |   STAPH. AUREUS DHFR, AR-101, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
1cz3:A     (LYS2) to    (LEU63)  DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA  |   DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE 
1cz3:B     (LYS2) to    (LEU63)  DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA  |   DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE 
2cd2:A     (SER6) to    (THR81)  LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+  |   OXIDO-REDUCTASE, FOLATE, NADPH, OXIDOREDUCTASE 
1daj:A     (SER6) to    (THR81)  COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS CARINII AND WILD TYPE HUMAN DIHYDROFOLATE REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3D]PYRIMIDINE ANTIFOLATE  |   OXIDOREDUCTASE 
2cig:A     (MET1) to    (SER66)  DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INHIBITED BY THE ACYCLIC 4R ISOMER OF INH-NADP A DERIVATIVE OF THE PRODRUG ISONIAZID.  |   NADP, ISONIAZID, REDUCTASE, INHIBITOR, BISUBSTRATE, TUBERCULOSIS, OXIDOREDUCTASE, ONE-CARBON METABOLISM 
1pd8:A     (LEU4) to    (SER76)  ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE  |   HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEX, OXIDOREDUCTASE 
1pd9:A     (LEU4) to    (SER76)  ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE  |   HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEXES, OXIDOREDUCTASE 
1pdb:A     (LEU4) to    (VAL74)  ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE  |   HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEXES, OXIDOREDUCTASE 
1df7:A     (VAL2) to    (LEU65)  DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE  |   DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, METHOTREXATE, TUBERCULOSIS, OXIDOREDUCTASE 
1dg5:A    (ILE14) to    (LEU65)  DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM  |   DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, TRIMETHOPRIM, TUBERCULOSIS, OXIDOREDUCTASE 
1dg7:A     (MET1) to    (LEU65)  DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210  |   DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, WR99210, ANTI-MALARIA AGENT, TUBERCULOSIS, OXIDOREDUCTASE 
1dg8:A    (ILE14) to    (LEU65)  DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH  |   DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, TUBERCULOSIS, OXIDOREDUCTASE 
1dhi:A     (MET1) to    (SER63)  LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE 
1dhi:B    (ILE14) to    (SER63)  LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE 
1dhj:A     (MET1) to    (SER63)  LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE 
1dhj:B    (ILE14) to    (SER63)  LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE 
1dis:A     (THR1) to    (THR63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE  |   INHIBITOR/ENZYME COMPLEX, OXIDO-REDUCTASE 
1dra:A     (MET1) to    (SER63)  CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING  |   OXIDOREDUCTASE 
1dra:B    (ILE14) to    (SER63)  CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING  |   OXIDOREDUCTASE 
1dre:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1drh:A     (MET1) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
3ghv:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE Q35K/N64F DOUBLE MUTANT INHIBITOR COMPLEX  |   DIHYDROFOLATE REDUCTASE, FOLATE ENZYME, ACTIVE SITE MUTANTS, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
3ghw:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEX  |   HUMAN DIHYDROFOALTE REDUCTASE INHIBITOR COMPLEX, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE 
4ixf:X     (SER6) to    (THR81)  PCDHFR-269 F69N VARIANT  |   PCDHFR-269-NADPH F69N TERNARY COMPLEX, REDUCTASE, OXIDOREDUCTASE- INHIBITOR COMPLEX 
2d0k:A    (ILE14) to    (SER63)  METHIONINE-FREE MUTANT OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE  |   ALPHA + BETA, OXIDOREDUCTASE 
2d0k:B    (ILE14) to    (SER63)  METHIONINE-FREE MUTANT OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE  |   ALPHA + BETA, OXIDOREDUCTASE 
1dyh:A     (MET1) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
1dyh:B    (ILE14) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
1dyi:A     (MET1) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
1dyi:B    (ILE14) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
1dyj:A     (MET1) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
1dyj:B    (ILE14) to    (SER63)  ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS  |   OXIDOREDUCTASE 
1dyr:A     (SER6) to    (THR81)  THE STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TO 1.9 ANGSTROMS RESOLUTION  |   OXIDO-REDUCTASE 
1e26:A     (SER6) to    (THR81)  DESIGN, SYNTHESIS AND X-RAY CRYSTAL STRUCTURE OF A POTENT DUAL INHIBITOR OF THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE AS AN ANTITUMOR AGENT.  |   OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, THYMIDYLATE SYNTHASE 
2d5n:B   (VAL148) to   (LEU219)  CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS  |   ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE 
2d5n:D   (VAL148) to   (VAL222)  CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS  |   ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE 
3td8:A    (ILE19) to    (THR81)  STRUCTURAL ANALYSIS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEX WITH NADPH AND 2,4-DIAMINO-5-METHYL-6-[2'-(4-CARBOXY-1- PENTYNYL)-5'-METHOXYBENZYL]PYRIDO[2,3-D]PYRIMIDINE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE 
2drc:A     (MET1) to    (SER63)  INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS  |   OXIDOREDUCTASE 
2drc:B    (ILE14) to    (SER63)  INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS  |   OXIDOREDUCTASE 
3gyf:A     (LEU4) to    (SER76)  HUMAN DHFR WITH Z-ISOMER IN ORTHORHOMBIC LATTICE  |   HUMAN DIHYDROFOLATE REDUCTASE PACKING, Z-ISOMER FUROPYRIMIDINE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
3tq8:A     (ILE3) to    (THR64)  STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH TRIMETHOPRIM  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3tq9:A     (ILE3) to    (THR64)  STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH METHOTREXATE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3tqb:A     (ILE3) to    (THR64)  STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH FOLATE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3tqa:A     (ILE3) to    (THR64)  STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH NADPH  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE 
2e0z:B   (ILE214) to   (LEU286)  CRYSTAL STRUCTURE OF VIRUS-LIKE PARTICLE FROM PYROCOCCUS FURIOSUS  |   VIRUS-LIKE PARTICLE, VIRUS, BACTERIOPHAGE, HK97, T4, VIRUS LIKE PARTICLE 
2e0z:C   (ILE214) to   (THR285)  CRYSTAL STRUCTURE OF VIRUS-LIKE PARTICLE FROM PYROCOCCUS FURIOSUS  |   VIRUS-LIKE PARTICLE, VIRUS, BACTERIOPHAGE, HK97, T4, VIRUS LIKE PARTICLE 
1qzf:A     (GLU3) to    (SER76)  CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE 
1qzf:B     (GLU3) to    (SER76)  CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE 
1qzf:C     (GLU3) to    (SER76)  CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE 
1qzf:D     (GLU3) to    (SER76)  CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE 
1qzf:E     (GLU3) to    (SER76)  CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE 
3hbb:A    (PHE23) to    (LEU99)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hbb:B    (PHE23) to    (LEU99)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hbb:C    (PHE23) to   (SER100)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hbb:D    (PHE23) to    (LEU99)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hj3:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT  |   TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE 
3hj3:B    (ILE19) to    (ILE75)  CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT  |   TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE 
3hj3:D    (SER17) to    (ILE75)  CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT  |   TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE 
1ra1:A    (ILE14) to    (LEU62)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1ra2:A    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1ra3:A    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1ra8:A    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2- MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1ra9:A    (ILE14) to    (LEU62)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rb2:B    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rb3:A    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rb3:B    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rd7:A    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rd7:B    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1re7:A    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1re7:B    (ILE14) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rf7:A     (MET1) to    (SER63)  STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rh3:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
4kak:A     (SER3) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDINE-4-YL)PHENYL]BUT-1- YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kak:B     (GLY2) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDINE-4-YL)PHENYL]BUT-1- YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kbn:A     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3-(3,5- PYRIMIDINE)]-PHENYL-PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2,4DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kbn:B    (ILE16) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3-(3,5- PYRIMIDINE)]-PHENYL-PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2,4DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kd7:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5(PYRIDINE-4-YL)PHENYL]PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2, 4-DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kd7:B     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5(PYRIDINE-4-YL)PHENYL]PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2, 4-DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4keb:A    (ILE16) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]BUT-1-YN-1-YL}6-ETHYLPYRIMIDINE-2,4- DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4keb:B     (GLY2) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]BUT-1-YN-1-YL}6-ETHYLPYRIMIDINE-2,4- DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kfj:A    (ILE16) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]PROP-1-YN-1-YL}6-ETHYLPRIMIDINE-2,4- DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kfj:B     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]PROP-1-YN-1-YL}6-ETHYLPRIMIDINE-2,4- DIAMINE  |   OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
1rx1:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rx2:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rx3:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rx5:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE  |   OXIDO-REDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
1rx6:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)  |   OXIDO-REDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
1rx8:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2'- MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDO-REDUCTASE 
1rx9:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
4kjj:A     (MET1) to    (SER63)  CRYOGENIC WT DHFR  |   ROSSMANN FOLD, OXIDOREDUCTASE 
4kjk:A     (MET1) to    (SER63)  ROOM TEMPERATURE WT DHFR  |   ROSSMANN FOLD, OXIDOREDUCTASE 
4kjl:A     (MET1) to    (SER64)  ROOM TEMPERATURE N23PPS148A DHFR  |   ROSSMANN FOLD, OXIDOREDUCTASE 
4klx:A    (ILE14) to    (LEU65)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN AN OPEN CONFORMATION.  |   REDUCTASE, OXIDOREDUCTASE 
4klx:B     (VAL2) to    (LEU65)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN AN OPEN CONFORMATION.  |   REDUCTASE, OXIDOREDUCTASE 
4km0:A    (ILE14) to    (LEU65)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PYRIMETHAMINE  |   REDUCTASE, OXIDOREDUCTASE 
4km0:B    (SER-1) to    (LEU65)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PYRIMETHAMINE  |   REDUCTASE, OXIDOREDUCTASE 
4km2:B     (VAL2) to    (LEU65)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN AN OPEN CONFORMATION IN COMPLEX WITH TRIMETHOPRIM  |   REDUCTASE, OXIDOREDUCTASE 
1s3v:A     (LEU4) to    (SER76)  STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY  |   DIHYDROFOLATE REDUCTASE, INHIBITOR, STEREOCHEMISTRY, OXIDOREDUCTASE 
1s3w:A     (LEU4) to    (SER76)  STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOALTES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY  |   DIHYDROFOLATE REDUCTASE, INHIBITOR COMPLEX, STEREOCHEMISTRY, OXIDOREDUCTASE 
1s3y:A     (SER6) to    (THR81)  STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY  |   PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE, INHIBITORS, STEREOCHEMISTRY, OXIDOREDUCTASE 
4kne:A    (ILE14) to    (SER66)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CYCLOGUANIL  |   REDUCTASE, OXIDOREDUCTASE 
4kne:B    (ILE14) to    (LEU65)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CYCLOGUANIL  |   REDUCTASE, OXIDOREDUCTASE 
1sej:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:B     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:C     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:D     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:E     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2fzi:A     (SER6) to    (THR81)  NEW INSIGHTS INTO DHFR INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES  |   DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM DERIVATIVES, RING STACKING INTERACTIONS, OXIDOREDUCTASE 
2fzj:A     (PRO3) to    (SER76)  NEW INSIGHTS INTO DHFR INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES  |   DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM DERIVATIVES, RING STACKING INTERACTIONS, OXIDOREDUCTASE 
3vco:A    (SER-1) to    (SER73)  SCHISTOSOMA MANSONI DIHYDROFOLATE REDUCTASE  |   REDUCTASE, OXIDOREDUCTASE 
4ky4:A     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:B     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:C     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:D     (LYS3) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:E     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:F     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:G     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:H     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky8:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:B     (VAL6) to    (SER76)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:C     (VAL6) to    (SER76)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:D     (VAL6) to    (SER76)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:E     (VAL6) to    (SER76)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
3i8a:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS H30N, F98Y DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6- ETHYLPYRIMIDINE (UCP120B)  |   NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4kya:B     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:C     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:D     (LYS3) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:E     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:F     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:H     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
3ia5:A     (VAL3) to    (SER64)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR)  |   DHFR DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE 
3ia5:B     (VAL3) to    (SER64)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR)  |   DHFR DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE 
2w3a:B     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
2w3b:A     (GLY2) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5- METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
2w3b:B    (ILE16) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5- METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
2w3m:A     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
2w3m:B     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
2w3v:A     (VAL6) to    (SER70)  MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
2w3w:A    (ILE18) to    (SER70)  MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5- METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)  |   NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE 
4lae:X     (LEU3) to    (THR64)  STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES  |   DHFR, PROTEIN-INHIBITOR COMPLEX, FOLATE, NADPH, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4lag:X     (LEU3) to    (THR64)  STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES  |   PROTEIN-INHIBITOR COMPLEX, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4lah:X     (LEU3) to    (THR64)  STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES  |   DHFR, PROTEIN-INHIBITOR COMPLEX, FOLATE, NADPH, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
1tdr:A     (MET1) to    (SER63)  EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE 
1tdr:B    (ILE14) to    (SER63)  EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE 
4lek:X     (LEU3) to    (THR64)  STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3inv:A    (PHE23) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH, DUMP AND C-448 ANTIFOLATE  |   DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE-TRANSFERASE COMPLEX 
3inv:B    (PHE23) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH, DUMP AND C-448 ANTIFOLATE  |   DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE-TRANSFERASE COMPLEX 
1hfp:A     (LEU4) to    (SER76)  COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE  |   OXIDOREDUCTASE, ONE-CARBON METABOLISM 
2w9s:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM  |   ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9s:B     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM  |   ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9s:C     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM  |   ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9s:D     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM  |   ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9s:E     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM  |   ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9s:F     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM  |   ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9t:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR  |   ANTIBIOTIC RESISTANCE, STAPHYLOCOCCUS AUREUS, DHFR, NADP, PLASMID, TRIMETHOPRIM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
2w9t:B     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS S1:DHFR  |   ANTIBIOTIC RESISTANCE, STAPHYLOCOCCUS AUREUS, DHFR, NADP, PLASMID, TRIMETHOPRIM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE 
3irm:A    (SER24) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irm:D    (PHE23) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:A    (PHE23) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:B    (PHE23) to   (SER100)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:C    (ALA19) to   (SER100)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:D    (PHE23) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3iro:B    (PHE23) to    (LEU99)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3iro:C    (PHE23) to   (SER100)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3ix9:A     (ILE5) to    (THR67)  CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT  |   CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE 
3ix9:B     (ILE5) to    (THR67)  CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT  |   CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE 
1u70:A     (PRO3) to    (SER76)  UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE  |   VARIANT DHFR MOUSE, HUMAN, OXIDOREDUCTASE 
4m6l:A     (LEU4) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE (DHFR) BOUND TO NADP+ AND 5,10-DIDEAZATETRAHYDROFOLIC ACID  |   ROSSMANN FOLD, NADPH BINDING, FOLATE BINDING, OXIDOREDUCTASE 
4m6j:A     (LEU4) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE (DHFR) BOUND TO NADPH  |   ROSSMANN FOLD, NADPH BINDING, FOLATE BINDING, OXIDOREDUCTASE 
4m6k:A     (LEU4) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE (DHFR) BOUND TO NADP+ AND FOLATE  |   ROSSMANN FOLD, NADPH BINDING, FOLATE BINDING, OXIDOREDUCTASE 
4m7u:A    (GLN-1) to    (THR64)  DIHYDROFOLATE REDUCTASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH NADP(H)  |   OXIDOREDUCTASE, REDUCTION OF DIHYDROFOLATE TO TETRAHYDROFOLATE 
4m7v:A     (LEU2) to    (THR64)  DIHYDROFOLATE REDUCTASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH NADP(H)AND RAB-PROPYL  |   OXIDOREDUCTASE, REDUCTION OF DIHYDROFOLATE TO TETRAHYDROFOLATE 
2inq:A     (MET1) to    (SER63)  NEUTRON CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BOUND TO THE ANTI-CANCER DRUG, METHOTREXATE  |   NEUTRON STRUCTURE; DEUTERIUM EXCHANGE; PSEUDO-ROSSMAN FOLD; NUCLEOTIDE BINDING DOMAIN; CHEMOTHERAPY, OXIDOREDUCTASE 
2inq:B    (ILE14) to    (SER63)  NEUTRON CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BOUND TO THE ANTI-CANCER DRUG, METHOTREXATE  |   NEUTRON STRUCTURE; DEUTERIUM EXCHANGE; PSEUDO-ROSSMAN FOLD; NUCLEOTIDE BINDING DOMAIN; CHEMOTHERAPY, OXIDOREDUCTASE 
1jol:A     (MET1) to    (SER63)  THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE  |   METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
1jol:B    (ILE14) to    (SER63)  THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE  |   METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
1k4p:A    (ASN38) to    (VAL83)  CRYSTAL STRUCTURE OF 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE IN COMPLEX WITH ZINC IONS  |   DIHYDROXYBUTANONE PHOSPHATE SYNTHASE, RIBOFLAVIN BIOSYNTHESIS, ANTIMICROBIAL TARGET, STRUCTURE-BASED DESIGN, ISOMERASE 
2jyb:A     (GLU2) to    (MET64)  BINARY HVDHFR1:FOLATE COMPLEX  |   DHFR, HALOPHILIC, FOLATE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
3zpg:A   (TYR152) to   (LEU229)  ACINETOBACTER BAUMANNII RIBD, FORM 2  |   REDUCTASE, DEAMINASE, HYDROLASE 
2lf1:A     (THR1) to    (THR63)  SOLUTION STRUCTURE OF L. CASEI DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH, 30 STRUCTURES  |   OXIDOREDUCTASE, DHFR, POSITIVE COOPERATIVITY, PROTEIN-LIGAND INTERACTIONS 
1klk:A     (SER6) to    (THR81)  CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH  |   STRUCTURE-BASED DESIGN, ANTIFOLATE, AIDS, PROTEIN-INHIBITOR COMPLEX, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
1kms:A     (SER3) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3- D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE  |   OXIDOREDUCTASE, ANTIPARASITIC DRUGS, REDUCTASE, LIPOPHILIC ANTIFOLATES 
1kmv:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)- 6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5- METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE  |   OXIDOREDUCTASE, ANTIPARASITIC DRUGS, REDUCTASE, LIPOPHILIC ANTIFOLATES 
4nx6:A     (MET1) to    (SER63)  SINGLE ROOM TEMPERATURE MODEL OF DHFR  |   FOLATE METABOLISM, OXIDOREDUCTASE 
4nx7:A     (MET1) to    (SER63)  SINGLE CRYOGENIC TEMPERATURE MODEL OF DHFR  |   FOLATE METABOLISM, OXIDOREDUCTASE 
5cc9:A     (MET1) to    (SER63)  L28F E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE  |   FOLATE METABOLISM, OXIDOREDUCTASE 
5ccc:A     (MET1) to    (SER63)  WILD-TYPE E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE  |   FOLATE METABOLISM, OXIDOREDUCTASE 
3jw3:A     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (F96I) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jw3:B     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (F96I) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jwc:A     (ARG2) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jwc:B     (ARG2) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jwf:A     (ARG2) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (R)-2,4-DIAMINO-5-(3-HYDROXY-3-(3, 4,5-TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP113A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jwf:B     (ARG2) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (R)-2,4-DIAMINO-5-(3-HYDROXY-3-(3, 4,5-TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP113A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jwm:A     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (S)-2,4-DIAMINO-5-(3-METHOXY-3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP114A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jwm:B     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (S)-2,4-DIAMINO-5-(3-METHOXY-3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP114A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
1lud:A     (THR1) to    (THR63)  SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES  |   DHFR, INHIBITOR/ENZYME COMPLEX, OXIDOREDUCTASE 
1lw3:A   (THR280) to   (ASP352)  CRYSTAL STRUCTURE OF MYOTUBULARIN-RELATED PROTEIN 2 COMPLEXED WITH PHOSPHATE  |   PROTEIN-PHOSPHATE COMPLEX, HYDROLASE 
1ly3:A     (SER6) to    (THR81)  ANALYSIS OF QUINAZOLINE AND PYRIDOPYRIMIDINE N9-C10 REVERSED BRIDGE ANTIFOLATES IN COMPLEX WITH NADP+ AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE  |   PCDHFR REVERSED BRIDGE ANTIFOLATES, OXIDOREDUCTASE 
2o7p:B   (TYR148) to   (ILE232)  THE CRYSTAL STRUCTURE OF RIBD FROM ESCHERICHIA COLI IN COMPLEX WITH THE OXIDISED NADP+ COFACTOR IN THE ACTIVE SITE OF THE REDUCTASE DOMAIN  |   NADP+ COMPLEX, ALPHA AND BETA CLASS WITH MAINLY PARALLELL BETA STRANDS, STRUCTURAL GENOMICS, HTP-PROTEIN ESCHERICHIA COLI, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, HYDROLASE, OXIDOREDUCTASE 
4or7:A     (MET1) to    (SER63)  KLEBSIELLA PNEUMONIAE DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-{3-[3-(PYRIMIDIN-5-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4- DIAMINE  |   5,6,7,8-TETRAHYDROFOLATE; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
1m74:A   (LEU352) to   (THR391)  CRYSTAL STRUCTURE OF MG-ADP-BOUND SECA FROM BACILLUS SUBTILIS  |   PROTEIN TRANSLOCATION; ATPASE; TRANSMEMBRANE TRANSPORT; HELICASE FAMILY STRUCTURE; MECHANOCHEMISTY, PROTEIN TRANSPORT 
4osg:A     (MET1) to    (ILE62)  KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4osg:B     (MET1) to    (SER63)  KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4osg:C     (MET1) to    (ILE62)  KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4osg:D     (MET1) to    (ILE62)  KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
1m7r:B   (THR280) to   (ASP352)  CRYSTAL STRUCTURE OF MYOTUBULARIN-RELATED PROTEIN-2 (MTMR2) COMPLEXED WITH PHOSPHATE  |   PROTEIN-PHOSPHATE COMPLEX, HYDROLASE 
3kfy:A     (ILE2) to    (SER63)  DYNAMIC SWITCHING AND PARTIAL OCCUPANCIES OF A SMALL MOLECULE INHIBITOR COMPLEX OF DHFR  |   SMALL MOLECULE INHIBITOR, DYNAMICS, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE 
3kjs:A    (PHE23) to    (LEU99)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
3kjs:B    (ALA19) to    (LEU99)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
3kjs:C    (ALA19) to    (LEU99)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
3kjs:D    (PHE23) to    (LEU99)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
4p3q:A    (ILE14) to    (SER63)  ROOM-TEMPERATURE WT DHFR, TIME-AVERAGED ENSEMBLE  |   ROSSMANN FOLD, OXIDOREDUCTASE 
4p3r:A     (ILE2) to    (SER63)  CRYOGENIC WT DHFR, TIME-AVERAGED ENSEMBLE  |   ROSSMANN FOLD, OXIDOREDUCTASE 
2zza:A     (VAL3) to    (LEU63)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE COMPLEX WITH NADP+ AND FOLATE  |   DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP, DEEP-SEA, HIGH PRESSURE, LOW TEMPERATURE, MORITELLA PROFUNDA, PIEZOPHILIC, PSYCHROPHILIC, PSYCHROPIEZOPHILIC, OXIDOREDUCTASE 
2zza:B     (VAL3) to    (LEU63)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE COMPLEX WITH NADP+ AND FOLATE  |   DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP, DEEP-SEA, HIGH PRESSURE, LOW TEMPERATURE, MORITELLA PROFUNDA, PIEZOPHILIC, PSYCHROPHILIC, PSYCHROPIEZOPHILIC, OXIDOREDUCTASE 
4p68:A     (ILE2) to    (LEU62)  ELECTROSTATICS OF ACTIVE SITE MICROENVIRONMENTS FOR E. COLI DHFR  |   ELECTROSTATICS, CATALYSIS, OXIDOREDUCTASE, DHFR 
1yho:A     (SER3) to    (SER76)  SOLUTION STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 25 STRUCTURES  |   DHFR, INHIBITOR/ENZYME COMPLEX, OXIDOREDUCTASE 
4pdj:A     (MET1) to    (SER63)  NEUTRON CRYSTAL STRUCTURE OF E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NADP+  |   ALPHA BETA ALPHA SANDWICH, OXIDOREDUCTASE 
3ky8:B     (ASN3) to    (SER75)  CRYSTAL STRUCTURE OF PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN (YP_001092907.1) FROM SHEWANELLA SP. PV-4 AT 2.12 A RESOLUTION  |   PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, BIOSYNTHETIC PROTEIN 
5dfr:A     (MET1) to    (SER63)  CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING  |   OXIDO-REDUCTASE, OXIDOREDUCTASE 
3l3r:A     (LEU4) to    (SER76)  STRUCTURAL, COMPUTATIONAL AND KINETIC DATA FOR ANTIFOLATE INTERACTIONS AGAINST PNEUMOCYSTIS JIROVECII, PNEUMOCYSTIS CARINII AND HUMAN DIHYDROFOLATE REDUCTASE AND THEIR ACTIVE SITE MUTANTS  |   DIHYDROFOLATE REDUCTASE, ANTIFOLATE, ACTIVE SITE MUTANTS, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE 
4pst:A     (MET1) to    (LEU62)  MULTICONFORMER MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 277 K  |   REDUCTASE, OXIDOREDUCTASE 
4psy:A     (MET1) to    (SER63)  100K CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE  |   REDUCTASE, OXIDOREDUCTASE 
4ptj:A     (MET1) to    (SER63)  ENSEMBLE MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 277K  |   ROSSMANN FOLD, OXIDOREDUCTASE 
3lg4:A     (THR1) to    (THR63)  STAPHYLOCOCCUS AUREUS V31Y, F92I MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-[(3S)-3-(5-METHOXY-2',6'-DIMETHYLBIPHENYL- 3-YL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4-DIAMINE  |   OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
3lg4:B     (THR1) to    (THR63)  STAPHYLOCOCCUS AUREUS V31Y, F92I MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-[(3S)-3-(5-METHOXY-2',6'-DIMETHYLBIPHENYL- 3-YL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4-DIAMINE  |   OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
1zdr:A     (ILE2) to    (THR63)  DHFR FROM BACILLUS STEAROTHERMOPHILUS  |   DHFR, NADP, OXIDOREDUCTASE 
1zdr:B     (ILE2) to    (THR63)  DHFR FROM BACILLUS STEAROTHERMOPHILUS  |   DHFR, NADP, OXIDOREDUCTASE 
4q0d:E     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:B     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:C     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:D     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
5dxv:A    (VAL30) to    (LEU79)  CRYSTAL STRUCTURE OF RETHREADED DHFR  |   PROTEIN DESIGN, DE NOVO PROTEIN 
5dxv:B    (VAL30) to    (SER80)  CRYSTAL STRUCTURE OF RETHREADED DHFR  |   PROTEIN DESIGN, DE NOVO PROTEIN 
1zsq:A   (THR280) to   (ASP352)  CRYSTAL STRUCTURE OF MTMR2 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE  |   PROTEIN-PHOSPHOLIPID COMPLEX, HYDROLASE 
4q67:A     (THR1) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH  |   OXIDOREDUCTASE 
4q6a:A     (THR1) to    (THR63)  STAPHYLOCOCCUS AUREUS V31L, F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH  |   OXIDOREDUCTASE 
5e8q:B    (ILE14) to    (SER63)  CRYSTAL STRUCTURE OF DHFR IN 20% ISOPROPANOL  |   DYNAMICS, OXIDOREDUCTASE 
5e8q:A     (MET1) to    (SER63)  CRYSTAL STRUCTURE OF DHFR IN 20% ISOPROPANOL  |   DYNAMICS, OXIDOREDUCTASE 
3m09:A     (LEU2) to    (THR63)  F98Y TMP-RESISTANT DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS WITH INHIBITOR RAB1  |   FOLATE, DHFR, ANTIMICROBIAL, ANTIBIOTIC RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
5eaj:B    (ILE14) to    (SER63)  CRYSTAL STRUCTURE OF DHFR IN 0% ISOPROPANOL  |   DYNAMICS, OXIDOREDUCTASE 
5eaj:A     (MET1) to    (SER63)  CRYSTAL STRUCTURE OF DHFR IN 0% ISOPROPANOL  |   DYNAMICS, OXIDOREDUCTASE 
4qi9:A     (ILE3) to    (SER64)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE  |   STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4qi9:B     (ILE3) to    (SER64)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE  |   STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4qi9:C     (ILE3) to    (SER64)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE  |   STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4qjz:D    (ILE19) to    (THR81)  PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH NADPH AND THE INHIBITOR 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL) PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)  |   ROSSMAN FOLD, HYDROLASE, NADPH AND FOLATE INHIBITOR, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4qle:A    (ALA14) to    (LEU62)  CRYSTAL STRUCTURE OF I14A DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+  |   DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE 
4qle:B    (ALA14) to    (LEU62)  CRYSTAL STRUCTURE OF I14A DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+  |   DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE 
4qlf:A     (MET1) to    (LEU62)  CRYSTAL STRUCTURE OF I14G DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+  |   DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE 
4qlg:A    (VAL14) to    (LEU62)  CRYSTAL STRUCTURE OF I14V DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+  |   DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE 
4qlg:B    (VAL14) to    (SER63)  CRYSTAL STRUCTURE OF I14V DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+  |   DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE 
4rgc:A    (ILE14) to    (SER63)  277K CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE  |   REDUCTASE, OXIDOREDUCTASE 
3cl9:A    (ALA19) to   (SER100)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH MTX  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP, MTX AND DUMP, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE- TRANSFERASE COMPLEX 
3clb:A    (ALA22) to   (SER100)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3clb:B    (PHE23) to    (LEU99)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3clb:D    (PHE23) to    (LEU99)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3ntz:A     (LEU4) to    (SER76)  DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTAL STRUCTURES OF NOVEL CLASSICAL 6,5,6-TRICYCLICBENZO[4,5]THIENO[2,3-D]PYRIMIDINES AS DUAL THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE INHIBITORS  |   DIHYDROFOLATE REDUCTASE, CYCLIZED INHIBITORS, OXIDOREDUCTASE HDHFR- 263-NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3nxx:A     (LEU4) to    (SER76)  PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO-2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE  |   CHIRAL MIXTURES PREFERENTIAL SELECTION, OXIDOREDUCTASE 
3nxy:A     (LEU4) to    (SER76)  PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALERNATE BINDING MODES OBSERVED FRO THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE  |   CHIRAL MIXTURES PREFERENTIAL BINDING, OXIDOREDUCTASE 
3nz6:X     (SER6) to    (THR81)  STRUCTURAL ANALYSIS OF PNEUMOCYSTIS CARINII AND HUMAN DHFR COMPLEXES WITH NADPH AND A SERIES OF FIVE POTENT 5-(OMEGA-CARBOXY(ALKYLOXY) PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES  |   PNEUMOCYSTIS CARINII DHFR INHIBITOR COMPLEXES, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3nz9:X    (ILE19) to    (THR81)  STRUCTURAL ANALYSIS OF PNEUMOCYSTIS CARINII AND HUMAN DHFR COMPLEXES WITH NADPH AND A SERIES OF FIVE POTENT 5-(OMEGA-CARBOXY(ALKYLOXY) PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES  |   PNEUMOCYSTIS CARINII DHFR INHIBITOR COMPLEXES, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3oaf:A     (LEU4) to    (SER76)  STRUCTURAL AND KINETIC DATA FOR ANTIFOLATE INTERACTIONS AGAINST PNEUMOCYSTIS JIROVECII, PNEUMOCYSTIS CARINII AND HUMAN DIHYDROFOLATE REDUCTASE AND THIER ACTIVE SITE MUTANTS  |   HDHFR INHIBITOR COMPLEXES, OXIDOREDUCTASE-INHIBITOR COMPLEX 
3och:A     (MET1) to    (SER63)  CHEMICALLY SELF-ASSEMBLED ANTIBODY NANORINGS (CSANS): DESIGN AND CHARACTERIZATION OF AN ANTI-CD3 IGM BIOMIMETIC  |   OXIDOREDUCTASE 
3och:B   (ILE214) to   (SER263)  CHEMICALLY SELF-ASSEMBLED ANTIBODY NANORINGS (CSANS): DESIGN AND CHARACTERIZATION OF AN ANTI-CD3 IGM BIOMIMETIC  |   OXIDOREDUCTASE 
3dat:A    (ARG13) to    (THR64)  CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DUAL-SITE INHIBITION, OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, ADENINE NUCLEOTIDE BINDING DOMAIN 
3dau:A    (ILE14) to    (LEU62)  CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, ADENINE NUCLEOTIDE BINDING DOMAIN, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE- CARBON METABOLISM, TRIMETHOPRIM RESISTANCE 
3dl5:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl5:B     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl5:C     (GLU3) to    (ILE75)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl5:D     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl5:E     (VAL6) to    (SER76)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl6:A     (VAL6) to    (SER76)  CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE 
3dl6:B     (GLU3) to    (SER76)  CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE 
3dl6:C    (VAL10) to    (SER76)  CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE 
3dl6:D     (VAL9) to    (SER76)  CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE 
3drc:A     (MET1) to    (SER63)  INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS  |   OXIDOREDUCTASE 
3drc:B    (ILE14) to    (SER63)  INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS  |   OXIDOREDUCTASE 
4ddr:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND P218  |   ANTIFOLATE, NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4dfr:A     (MET1) to    (SER63)  CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE  |   OXIDO-REDUCTASE 
4dfr:B    (ILE14) to    (SER63)  CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE  |   OXIDO-REDUCTASE 
5hi6:A     (ILE3) to    (SER64)  THE HIGH RESOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEX WITH METHOTREXATE AS CLOSED FORM  |   STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, DIHYDROFOLATE REDUCTASE, YERSINIA PESTIS, OXIDOREDUCTASE 
3e0b:A     (ARG2) to    (THR64)  BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2, 4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B)  |   OXIDOREDUCTASE 
3e0b:B     (ARG2) to    (THR64)  BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2, 4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B)  |   OXIDOREDUCTASE 
4eck:A     (LYS3) to   (VAL102)  CRYSTAL STRUCTURE OF THE TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, TRANSFERASE, OXIDOREDUCTASE 
4eck:B    (PRO26) to   (SER103)  CRYSTAL STRUCTURE OF THE TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, TRANSFERASE, OXIDOREDUCTASE 
4eig:A     (MET1) to    (SER63)  CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR  |   NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
4eiz:A     (MET1) to    (SER63)  STRUCTURE OF NB113 BOUND TO APODHFR  |   NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
4eiz:B     (MET1) to    (SER63)  STRUCTURE OF NB113 BOUND TO APODHFR  |   NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
4ej1:A     (MET1) to    (SER63)  BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX  |   FOLATE, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
4ej1:B     (MET1) to    (SER63)  BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX  |   FOLATE, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
4ele:A     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:B     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:C     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:D     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:E     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:F     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:G     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4ele:H     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:A     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:H     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:C     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:B     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:G     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:F     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:D     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elh:E     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3qfx:A    (PHE29) to   (LEU105)  TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE PYRIMETHAMINE COMPLEX  |   PYRIMETHAMINE, ANTIFOLATE RESISTANCE, TRYPANOSOME, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3qfx:B    (PHE29) to   (LEU105)  TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE PYRIMETHAMINE COMPLEX  |   PYRIMETHAMINE, ANTIFOLATE RESISTANCE, TRYPANOSOME, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3ql0:A    (ILE14) to    (SER63)  CRYSTAL STRUCTURE OF N23PP/S148A MUTANT OF E. COLI DIHYDROFOLATE REDUCTASE  |   ROSSMANN FOLD, OXIDOREDUCTASE 
3ql3:A     (MET1) to    (SER63)  RE-REFINED COORDINATES FOR PDB ENTRY 1RX2  |   ROSSMANN FOLD, DIHYDROFOLATE, TETRAHYDROFOLATE, NADPH, COFACTOR, OXIDOREDUCTASE 
3qlw:A    (LEU17) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- [3-(2,5-DIMETHOXYPHENYL)PROP-1-YN-1-YL]-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP120B)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3qlw:B     (VAL6) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- [3-(2,5-DIMETHOXYPHENYL)PROP-1-YN-1-YL]-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP120B)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4fhb:A    (ILE14) to    (LEU62)  ENHANCING DHFR CATALYSIS BY BINDING OF AN ALLOSTERIC REGULATOR NANOBODY (NB179)  |   NANOBODY, DIHYDROFOLATE REDUCTASE, ALLOSTERIC ACTIVATOR, REDUCTASE, OXIDOREDUCTASE-PROTEIN BINDING COMPLEX 
3qyl:A     (ILE2) to    (SER63)  SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE  |   ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE 
3qyo:A     (MET1) to    (SER63)  SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE  |   ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE 
5ja3:A    (ILE14) to    (LEU65)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106)  |   DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE 
5ja3:B    (ILE14) to    (SER66)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106)  |   DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE 
5ja3:C    (ILE14) to    (SER66)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106)  |   DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE 
5ja3:D     (VAL2) to    (SER66)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106)  |   DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE 
4g3m:D   (VAL148) to   (LEU219)  COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG: THE DEAMINATION PROCESS IN RIBOFLAVIN BIOSYNTHESIS  |   ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE 
4g95:A     (LEU4) to    (SER76)  HDHFR-OAG BINARY COMPLEX  |   DIHYDROFOLATE REDUCTASE, ANTIFOLATE, OXIDOREDUCTASE 
4gh8:A     (MET1) to    (SER67)  CRYSTAL STRUCTURE OF A 'HUMANIZED' E. COLI DIHYDROFOLATE REDUCTASE  |   TETRAHYDROFOLATE, ENZYME CATALYSIS, EVOLUTION, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE 
5t0l:A     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF TOXOPLASMA GONDII TS-DHFR COMPLEXED WITH NADPH, DUMP, PDDF AND 5-(4-(3,4-DICHLOROPHENYL)PIPERAZIN-1-YL)PYRIMIDINE-2, 4-DIAMINE (TRC-15)  |   TOXOPLASMA GONDII, DHFR, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
5t0l:B     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF TOXOPLASMA GONDII TS-DHFR COMPLEXED WITH NADPH, DUMP, PDDF AND 5-(4-(3,4-DICHLOROPHENYL)PIPERAZIN-1-YL)PYRIMIDINE-2, 4-DIAMINE (TRC-15)  |   TOXOPLASMA GONDII, DHFR, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
6dfr:A     (MET1) to    (SER63)  CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE  |   OXIDO-REDUCTASE 
7dfr:A     (MET1) to    (LEU62)  CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE  |   OXIDO-REDUCTASE 
2ano:A     (MET1) to    (LEU62)  CRYSTAL STRUCTURE OF E.COLI DIHYDROFOLATE REDUCTASE IN COMPLEX WITH NADPH AND THE INHIBITOR MS-SH08-17  |   DHFR, PROTEIN INHIBITOR COMPLEX, OXIDOREDUCTASE 
4h96:A    (LEU17) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4h96:B     (VAL6) to    (SER78)  CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018)  |   ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3f0v:X     (THR1) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(2,6-DIMETHYLPHENYL) PHENYL)BUT-1-YNYL]-6-METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
3f0x:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL) PHENYL)BUT-1-YNYL]-6-METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
4x5j:A    (ILE14) to    (LEU62)  ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 750 MPA  |   OXIDOREDUCTASE 
3s7a:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE BINARY COMPLEX WITH PT684  |   SINGLE POLYPEPTIDE CHAIN, REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4i13:A     (MET1) to    (SER63)  NANOBODY CA1697 BINDING TO THE DHFR.FOLATE BINARY COMPLEX  |   ALPHA/BETA FOLD, IMMUNOGLOBULIN FOLD, REDUCTASE, NADPH, FOLATE DERIVATIVES, REDUCTION, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX 
3sgy:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3sgy:B     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)  |   OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
3fqo:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL]-6- ETHYLPYRIMIDINE (UCP120B)  |   OXIDOREDUCTASE 
3fqv:A     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-4-PHENYLPHENYL)BUT-1- YNYL]-6-METHYLPYRIMIDINE  |   OXIDOREDUCTASE 
3fra:X     (LEU2) to    (THR63)  STAPHYLOCOCCUS AUREUS F98Y DHFR COMPLEXED WITH ICLAPRIM  |   DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM 
1d1g:A     (LYS2) to    (LEU63)  DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA  |   DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE 
1d1g:B     (LYS2) to    (LEU63)  DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA  |   DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE 
1ddr:A     (MET1) to    (SER63)  MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA  |   OXIDO-REDUCTASE 
1ddr:B    (ILE14) to    (SER63)  MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA  |   OXIDO-REDUCTASE 
1dds:A     (MET1) to    (SER63)  MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE  |   OXIDO-REDUCTASE 
1dds:B    (ILE14) to    (SER63)  MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE  |   OXIDO-REDUCTASE 
2qk8:A     (VAL3) to    (THR64)  CRYSTAL STRUCTURE OF THE ANTHRAX DRUG TARGET, BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE  |   OXIDOREDUCTASE, METHOTREXATE, PTERIDINE BINDING, NUCLEOTIDE PHOSPHATE BINDING, PSEUDO-ROSSMAN FOLD 
1dhf:A    (ILE16) to    (SER76)  CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE  |   OXIDO-REDUCTASE 
1dlr:A     (LEU4) to    (SER76)  METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS  |   OXIDO-REDUCTASE 
1drb:A     (MET1) to    (SER63)  CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING  |   OXIDOREDUCTASE 
1drb:B    (ILE14) to    (SER63)  CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING  |   OXIDOREDUCTASE 
1drf:A     (LEU4) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE  |   OXIDOREDUCTASE (CH-NH(D)-NAD OR NADP(A)) 
3gi2:A     (LEU4) to    (SER76)  HUMAN DIHYDROFOLATE REDUCTASE Q35K MUTANT INHIBITOR COMPLEX  |   DIHYDROFOLATE REDUCTASE, FOLATE ENZYME, ACTIVE SITE MUTANTS, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
4ixg:X     (SER6) to    (THR81)  PCDHFR-268-K37S-N69F VARIANT  |   DIHYDROFOLATE REDUCTASE INHIBITOR TERNARY COMPLEX DOUBLE VARIANT, REDUCTASE, OXIDOREDUCTASE-INHIBITOR COMPLEX 
2dhf:A     (LEU4) to    (SER76)  CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE  |   OXIDO-REDUCTASE 
2dhf:B     (LEU4) to    (SER76)  CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE  |   OXIDO-REDUCTASE 
1rc4:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rg7:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1rx4:A     (MET1) to    (SER63)  DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND 2'-MONOPHOSPHOADENOSINE 5'- DIPHOSPHORIBOSE  |   OXIDO-REDUCTASE NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE 
1rx7:A     (MET1) to    (SER63)  STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE  |   OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM 
1s3u:A     (LEU4) to    (SER76)  STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY  |   DIHYDROFOLATE REDUCTASE, INHIBITOR COMPLEX, OXIDOREDUCTASE 
2fzh:A     (SER6) to    (THR81)  NEW INSIGHTS INTO DIHYDROFOLATE REDUCTASE INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES  |   DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM DERIVATIVES, RING STACKING INTERACTIONS, OXIDOREDUCTASE 
3ia4:A    (ILE15) to    (LEU63)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX)  |   DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE 
3ia4:B    (ILE15) to    (LEU63)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX)  |   DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE 
3ia4:C     (VAL3) to    (LEU63)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX)  |   DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE 
3ia4:D    (ILE15) to    (LEU63)  MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX)  |   DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE 
1hfr:A     (LEU4) to    (SER76)  COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE  |   OXIDOREDUCTASE, ONE-CARBON METABOLISM 
2h2q:A    (PHE23) to    (LEU99)  CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND DUMP, OXIDOREDUCTASE, TRANSFERASE 
2w9g:A     (THR1) to    (THR63)  WILD-TYPE STAPHYLOCOCCUS AUREUS DHFR IN COMPLEX WITH NADPH AND TRIMETHOPRIM  |   OXIDOREDUCTASE, ONE-CARBON METABOLISM 
2w9h:A     (LEU2) to    (THR63)  WILD-TYPE STAPHYLOCOCCUS AUREUS DHFR IN COMPLEX WITH TRIMETHOPRIM  |   OXIDOREDUCTASE, ONE-CARBON METABOLISM 
2hqp:A     (THR1) to    (HIS64)  SOLUTION STRUCTURE OF L.CASEI DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH, 32 STRUCTURES  |   OXIDOREDUCTASE, DHFR 
1u71:A     (LEU4) to    (SER76)  UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE TERNARY CRYSTAL COMPLEXES WITH METHOTREXATE AND NADPH  |   HUMAN DHFR L22R VARIANT, OXIDOREDUCTASE 
4m2x:A     (VAL2) to    (LEU65)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ)  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4m2x:C    (ILE14) to    (LEU65)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ)  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4m2x:E    (ILE14) to    (SER66)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ)  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4m2x:G     (VAL2) to    (LEU65)  MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ)  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
1jom:A     (MET1) to    (SER63)  THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE  |   METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM OXIDOREDUCTASE 
3jvx:A     (ARG2) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5-TRIMETHOXYPHENYL) PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3jvx:B     (ARG2) to    (THR64)  CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5-TRIMETHOXYPHENYL) PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A)  |   OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3k74:A     (MET1) to    (SER63)  DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY  |   IMMUNOGLOBULIN, PROTEIN-NANOBODY COMPLEX, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE 
4om7:A   (ILE669) to   (LEU735)  CRYSTAL STRUCTURE OF TIR DOMAIN OF TLR6  |   TIR FOLD, PROTEIN INTERACTION, SIGNALING PROTEIN 
1mvs:A     (LEU4) to    (SER76)  ANALYSIS OF TWO POLYMORPHIC FORMS OF A PYRIDO[2,3- D]PYRIMIDINE N9-C10 REVERSE-BRIDGE ANTIFOLATE BINARY COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, HUMAN DHFR, ANTIFOLATE, N9-C10 REVERSE BRIDGE PYROLOPYRIMIDINE, OXIDOREDUCTASE 
1mvt:A     (LEU4) to    (SER76)  ANALYSIS OF TWO POLYMORPHIC FORMS OF A PYRIDO[2,3- D]PYRIMIDINE N9-C10 REVERSE-BRIDGE ANTIFOLATE BINARY COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, HUMAN DHFR, ANTIFOLATE, N9-C10 REVERSE BRIDGE PYROLOPYRIMIDINE, OXIDOREDUCTASE 
4pss:A     (MET1) to    (SER63)  MULTICONFORMER MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 100K  |   REDUCTASE, OXIDOREDUCTASE 
4pth:A     (MET1) to    (SER63)  ENSEMBLE MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 100K  |   ROSSMANN FOLD, OXIDOREDUCTASE 
4q0e:A     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:B     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:C     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:D     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:E     (VAL6) to    (ILE75)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
1zvr:A   (THR280) to   (ASP352)  CRYSTAL STRUCTURE OF MTMR2 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE  |   PROTEIN-PHOSPHOINOSITIDE COMPLEX, HYDROLASE 
3m08:A     (LEU2) to    (THR63)  WILD TYPE DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS WITH INHIBITOR RAB1  |   FOLATE, DHFR, ANTIMICROBIAL, ANTIBIOTIC RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE', OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
5ecc:A     (LYS1) to    (THR62)  KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(2- METHOXY-5-(PYRIDIN-4-YL)PHENYL)PROP-1-YN-1-YL)PYRIMIDINE-2,4-DIAMINE  |   OXIDOREDUCTASE, ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
5ecx:A     (LYS1) to    (THR62)  KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(6- (PYRIDIN-4-YL)BENZO[D][1,3]DIOXOL-4-YL)BUT-1-YN-1-YL)PYRIMIDINE-2,4- DIAMINE  |   ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
5ecx:B     (LYS1) to    (ARG63)  KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(6- (PYRIDIN-4-YL)BENZO[D][1,3]DIOXOL-4-YL)BUT-1-YN-1-YL)PYRIMIDINE-2,4- DIAMINE  |   ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX 
4qhv:A     (LEU4) to    (SER76)  CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE AS COMPLEX WITH PYRIDOPYRIMIDINE 22 (N~6~-METHYL-N~6~-[4-(PROPAN-2-YL) PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)  |   INHIBITOR BINDING, ROSSMAN FOLD, HYDROLASE, INHIBITOR, COFACTOR NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3nxr:A     (LEU4) to    (SER76)  PERFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE  |   CHIRAL SELECTION E- Z-ISOMERS, OXIDOREDUCTASE 
3nxv:A     (LEU4) to    (SER76)  PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE  |   CHIRAL MIXTURE, E-Z-ISOMERS, OXIDOREDUCTASE 
4eil:A     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:B     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:C     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:D     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:E     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:F     (PRO4) to   (SER103)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:G     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:H     (PRO4) to   (VAL102)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4elf:A     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:B     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:C     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:D     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:E     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:F     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:G     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elf:H     (VAL3) to    (ARG65)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:A     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:H     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:C     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:B     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:G     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:F     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:D     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elb:E     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:A     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:B     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:C     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:D     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:E     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:F     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:G     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4elg:H     (VAL3) to    (THR64)  STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
4fgg:A     (LEU2) to    (THR63)  S. AUREUS DIHYDROFOLATE REDUCTASE CO-CRYSTALLIZED WITH PROPYL-DAP ISOBUTENYL-DIHYDROPHTHALAZINE INHIBITOR  |   DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-INHIBITOR COMPLEX 
4fgh:A     (VAL6) to    (THR63)  S. AUREUS DIHYDROFOLATE REDUCTASE CO-CRYSTALLIZED WITH ETHYL-DAP ISOBUTENYL-DIHYDROPHTHALAZINE INHIBITOR  |   OXIDOREDUCTASE-INHIBITOR COMPLEX 
3r33:A     (MET1) to    (LEU62)  EVIDENCE FOR DYNAMIC MOTION IN PROTEINS AS A MECHANISM FOR LIGAND DISSOCIATION  |   ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE 
3rg9:A    (PHE29) to   (SER106)  TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE (TBDHFR) IN COMPLEX WITH WR99210  |   TRYPANOSOMA BRUCEI, OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, WR99210, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX 
3rg9:B    (PHE29) to   (SER106)  TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE (TBDHFR) IN COMPLEX WITH WR99210  |   TRYPANOSOMA BRUCEI, OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, WR99210, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX