3ro9:A (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3ro9:B (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3roa:A (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-[(3R)-3-[3-METHOXY-5-(MORPHOLIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1004) | ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
2anq:A (MET1) to (SER63) CRYSTAL STRUCTURE OF E.COLI DHFR IN COMPLEX WITH NADPH AND THE INHIBITOR COMPOUND 10A. | DHFR, PROTEIN INHIBITOR COMPLEX, OXIDOREDUCTASE
2oip:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:B (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:C (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:D (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:E (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
3eel:A (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH 2,4-DIAMINO-5- [3-METHYL-3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL)PHENYL)PROP-1-YNYL]-6- METHYLPYRIMIDINE(UCP11153TM) AND NADPH | ENZYME, OXIDOREDUCTASE
3eem:B (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH 2,4-DIAMINO-5- [3-METHYL-3-(3-METHOXY-5-(2,6-DIMETHYLPHENYL)PHENYL)PROP-1-YNYL]-6- METHYLPYRIMIDINE(UCP111D26M) AND NADPH | ENZYME, OXIDOREDUCTASE
1ao8:A (THR1) to (THR63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES | OXIDOREDUCTASE, INHIBITOR/ENZYME COMPLEX
2b3z:D (TYR147) to (VAL222) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN AND REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4h95:A (VAL6) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-{3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL}PYRIMIDINE-2,4-DIAMINE (UCP1006) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4h95:B (LEU17) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ETHYL-5-{3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL}PYRIMIDINE-2,4-DIAMINE (UCP1006) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4h97:A (LEU17) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-METHOXY-5-(4-METHYLPHENYL)PHENYL]BUT-1-YN-1-YL}-6- METHYLPYRIMIDINE-2,4-DIAMINE (UCP111D4M) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4h97:B (VAL6) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-METHOXY-5-(4-METHYLPHENYL)PHENYL]BUT-1-YN-1-YL}-6- METHYLPYRIMIDINE-2,4-DIAMINE (UCP111D4M) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4h98:A (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018) | ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4h98:B (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018) | ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
2oz5:A (ARG26) to (PRO81) CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEIN TYROSINE PHOSPHATASE PTPB IN COMPLEX WITH THE SPECIFIC INHIBITOR OMTS | PROTEIN TYROSINE PHOSPHATASE IN COMPLEX WITH SMALL MOLECULE INHIBITOR, STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, UNKNOWN FUNCTION
4ha9:A (VAL32) to (ILE105) STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7 | REDUCTASE, NADPH BINDING, OXIDOREDUCTASE
3ex8:C (TYR147) to (THR221) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE
3ex8:D (VAL148) to (LEU219) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG REDUCTION MECHANISM IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NADP, RIBOFLAVIN BIOSYNTHESIS, ZINC, HYDROLASE, OXIDOREDUCTASE
3s3v:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE Q35K/N64F DOUBLE MUTANT BINARY COMPLEX WITH TRIMETHOPRIM | NOVEL SECOND BINDING SITE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3f0b:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-PHENYLPHENYL)BUT-1-YNYL]-6- METHYLPYRIMIDINE | OXIDOREDUCTASE
3f0s:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL)PHENYL)BUT-1-YNYL]- 6-METHYLPYRIMIDINE | OXIDOREDUCTASE
3f0u:X (THR1) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-PHENYLPHENYL)BUT-1- YNYL]-6-METHYLPYRIMIDINE | OXIDOREDUCTASE
4x5f:A (ILE14) to (LEU62) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 0.1 MPA | OXIDOREDUCTASE
4x5f:B (ILE14) to (SER63) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 0.1 MPA | OXIDOREDUCTASE
4x5g:A (ILE14) to (LEU62) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 270 MPA | OXIDOREDUCTASE
4x5g:B (ILE14) to (SER63) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 270 MPA | OXIDOREDUCTASE
4x5h:A (ILE14) to (LEU62) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 500 MPA | OXIDOREDUCTASE
4x5i:A (ILE14) to (LEU62) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 660 MPA | OXIDOREDUCTASE
1boz:A (LEU4) to (SER76) STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4- DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS | OXIDOREDUCTASE
4hog:B (VAL6) to (SER78) CANDIDA GLABRATA DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- [3-(2-METHOXY-4-PHENYLPHENYL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4- DIAMINE (UCP111H) | ANTIFUNGAL AGENTS, CANDIDA GLABRATA, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3f8z:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE STRUCTURAL DATA WITH ACTIVE SITE MUTANT ENZYME COMPLEXES | ACTIVE SITE MUTANTS LIGAND COMPLEX HUMAN DIHYDROFOLATE REDUCTASE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
3s9u:A (ARG2) to (THR64) BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP120J | OXIDOREDUCTASE
3sa1:B (VAL3) to (THR64) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1021 | OXIDOREDUCTASE
3sa2:A (VAL3) to (THR64) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1014 | OXIDOREDUCTASE
3sa2:B (VAL3) to (THR64) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND PROPARGYL-LINKED TMP ANALOG, UCP1014 | OXIDOREDUCTASE
3saf:B (GLU336) to (ASP388) CRYSTAL STRUCTURE OF THE HUMAN RRP6 CATALYTIC DOMAIN WITH D313N MUTATION IN THE ACTIVE SITE | EXORIBONUCLEASE, RNA EXOSOME, HYDROLASE
3sai:A (ARG2) to (THR64) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP1015 | OXIDOREDUCTASE
3sai:B (VAL3) to (THR64) BACUILLS ANTHRACIS DIHYDROFOLATE REDUCTASE BOUND TO PROPARGYL-LINKED TMP ANALOG, UCP1015 | OXIDOREDUCTASE
1bzf:A (THR1) to (THR63) NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES | OXIDOREDUCTASE, INHIBITOR/ENZYME COMPLEX
4xe6:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1061) | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4xec:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1061) | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS, ANTIFOLATES, ENANTIOPURE INHIBITORS, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4i1n:A (MET1) to (SER63) R104A-CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX | ALPHA/BETA FOLD, IMMUNOGLOBULIN FOLD, REDUCTASE, NADPH, FOLATE DERIVATIVES, HYDRIDE TRANSFER, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
1ohk:A (ILE16) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM | OXIDOREDUCTASE
3sh2:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(4-METHOXYBIPHENYL-3-YL)PROP-1-YNYL)PYRIMIDINE-2,4- DIAMINE (UCP120J) | OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3sh2:B (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(4-METHOXYBIPHENYL-3-YL)PROP-1-YNYL)PYRIMIDINE-2,4- DIAMINE (UCP120J) | OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
2c2s:A (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4- DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, A NOVEL BORON CONTAINING, NONCLASSICAL ANTIFOLATE | NONCLASSICAL ANTIFOLATES, LIPOPHILIC ANTIFOLATES, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE, REDUCTASE
2c2t:A (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4- DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6- METHYLPYRIMIDINE, A NOVEL BORON CONTAINING, NONCLASSICAL ANTIFOLATE | NONCLASSICAL ANTIFOLATES, LIPOPHILIC ANTIFOLATES, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE, REDUCTASE
3fl8:A (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:B (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:C (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:D (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:E (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:F (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:G (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl8:H (VAL3) to (ARG65) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH RAB1, A TMP-DIHYDROPHTHALAZINE DERIVATIVE | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:A (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:B (VAL3) to (ARG65) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:C (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:D (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:E (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:F (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:G (VAL3) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fl9:H (ARG13) to (THR64) CRYSTAL STRUCTURE OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE (DHFR) WITH TRIMETHOPRIM | OXIDOREDUCTASE, PYRIMIDINE, DIHYDROPHTHALAZINE
3fq0:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
3fqc:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]-6- METHYLPYRIMIDINE (UCP115A) | OXIDOREDUCTASE
3fqc:B (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]-6- METHYLPYRIMIDINE (UCP115A) | OXIDOREDUCTASE
3fqf:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YNYL]- 6-METHYLPYRIMIDINE (UCP115A) | OXIDOREDUCTASE
3fqz:A (ILE14) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-4-PHENYLPHENYL)BUT-1-YNYL]-6- METHYLPYRIMIDINE | OXIDOREDUCTASE
3frb:X (LEU2) to (THR63) S. AUREUS F98Y DHFR COMPLEXED WITH TMP | S. AUREUS DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3frd:X (LEU2) to (THR63) S. AUREUS DHFR COMPLEXED WITH NADPH AND FOLATE | S AUREUS DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3fre:X (THR1) to (THR63) S. AUREUS DHFR COMPLEXED WITH NADPH AND TMP | DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3frf:X (THR1) to (THR63) S. AUREUS DHFR COMPLEXED WITH NADPH AND ICLAPRIM | DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3sqy:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3sr5:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srq:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srr:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srs:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3sru:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3srw:X (LEU3) to (THR64) S. AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NOVEL 7-ARYL-2,4- DIAMINOQUINAZOLINES | DIHYDROFOLATE REDUCTASE, DHFR, DRUG DESIGN, ENZYME INHIBITORS, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3fy9:X (LEU2) to (THR63) STAPH. AUREUS DHFR F98Y COMPLEXED WITH AR-102 | DHFR, AR-102, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3fy8:X (LEU2) to (THR63) CRYSTAL STRUCTURE OF STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR- 101 | DHFR, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
3fyv:X (LEU2) to (THR63) STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR-102 | DHFR, STAPH.AUREUS, AR-102, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3fyw:X (LEU2) to (THR63) STAPH. AUREUS DHFR COMPLEXED WITH NADPH AND AR-101 | STAPH. AUREUS DHFR, AR-101, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
1cz3:A (LYS2) to (LEU63) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1cz3:B (LYS2) to (LEU63) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
2cd2:A (SER6) to (THR81) LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+ | OXIDO-REDUCTASE, FOLATE, NADPH, OXIDOREDUCTASE
1daj:A (SER6) to (THR81) COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS CARINII AND WILD TYPE HUMAN DIHYDROFOLATE REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3D]PYRIMIDINE ANTIFOLATE | OXIDOREDUCTASE
2cig:A (MET1) to (SER66) DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS INHIBITED BY THE ACYCLIC 4R ISOMER OF INH-NADP A DERIVATIVE OF THE PRODRUG ISONIAZID. | NADP, ISONIAZID, REDUCTASE, INHIBITOR, BISUBSTRATE, TUBERCULOSIS, OXIDOREDUCTASE, ONE-CARBON METABOLISM
1pd8:A (LEU4) to (SER76) ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE | HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEX, OXIDOREDUCTASE
1pd9:A (LEU4) to (SER76) ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE | HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEXES, OXIDOREDUCTASE
1pdb:A (LEU4) to (VAL74) ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE | HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEXES, OXIDOREDUCTASE
1df7:A (VAL2) to (LEU65) DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE | DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, METHOTREXATE, TUBERCULOSIS, OXIDOREDUCTASE
1dg5:A (ILE14) to (LEU65) DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM | DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, TRIMETHOPRIM, TUBERCULOSIS, OXIDOREDUCTASE
1dg7:A (MET1) to (LEU65) DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210 | DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, WR99210, ANTI-MALARIA AGENT, TUBERCULOSIS, OXIDOREDUCTASE
1dg8:A (ILE14) to (LEU65) DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH | DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, TUBERCULOSIS, OXIDOREDUCTASE
1dhi:A (MET1) to (SER63) LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
1dhi:B (ILE14) to (SER63) LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
1dhj:A (MET1) to (SER63) LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
1dhj:B (ILE14) to (SER63) LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
1dis:A (THR1) to (THR63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE | INHIBITOR/ENZYME COMPLEX, OXIDO-REDUCTASE
1dra:A (MET1) to (SER63) CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING | OXIDOREDUCTASE
1dra:B (ILE14) to (SER63) CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING | OXIDOREDUCTASE
1dre:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1drh:A (MET1) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
3ghv:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE Q35K/N64F DOUBLE MUTANT INHIBITOR COMPLEX | DIHYDROFOLATE REDUCTASE, FOLATE ENZYME, ACTIVE SITE MUTANTS, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
3ghw:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE INHIBITOR COMPLEX | HUMAN DIHYDROFOALTE REDUCTASE INHIBITOR COMPLEX, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE
4ixf:X (SER6) to (THR81) PCDHFR-269 F69N VARIANT | PCDHFR-269-NADPH F69N TERNARY COMPLEX, REDUCTASE, OXIDOREDUCTASE- INHIBITOR COMPLEX
2d0k:A (ILE14) to (SER63) METHIONINE-FREE MUTANT OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE | ALPHA + BETA, OXIDOREDUCTASE
2d0k:B (ILE14) to (SER63) METHIONINE-FREE MUTANT OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE | ALPHA + BETA, OXIDOREDUCTASE
1dyh:A (MET1) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyh:B (ILE14) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyi:A (MET1) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyi:B (ILE14) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyj:A (MET1) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyj:B (ILE14) to (SER63) ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5- DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | OXIDOREDUCTASE
1dyr:A (SER6) to (THR81) THE STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TO 1.9 ANGSTROMS RESOLUTION | OXIDO-REDUCTASE
1e26:A (SER6) to (THR81) DESIGN, SYNTHESIS AND X-RAY CRYSTAL STRUCTURE OF A POTENT DUAL INHIBITOR OF THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE AS AN ANTITUMOR AGENT. | OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, THYMIDYLATE SYNTHASE
2d5n:B (VAL148) to (LEU219) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE
2d5n:D (VAL148) to (VAL222) CRYSTAL STRUCTURE OF A BIFUNCTIONAL DEAMINASE AND REDUCTASE INVOLVED IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA; TWO SEPARATE FUNCTIONAL DOMAINS, HYDROLASE, OXIDOREDUCTASE
3td8:A (ILE19) to (THR81) STRUCTURAL ANALYSIS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEX WITH NADPH AND 2,4-DIAMINO-5-METHYL-6-[2'-(4-CARBOXY-1- PENTYNYL)-5'-METHOXYBENZYL]PYRIDO[2,3-D]PYRIMIDINE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
2drc:A (MET1) to (SER63) INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS | OXIDOREDUCTASE
2drc:B (ILE14) to (SER63) INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS | OXIDOREDUCTASE
3gyf:A (LEU4) to (SER76) HUMAN DHFR WITH Z-ISOMER IN ORTHORHOMBIC LATTICE | HUMAN DIHYDROFOLATE REDUCTASE PACKING, Z-ISOMER FUROPYRIMIDINE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
3tq8:A (ILE3) to (THR64) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH TRIMETHOPRIM | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3tq9:A (ILE3) to (THR64) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH METHOTREXATE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3tqb:A (ILE3) to (THR64) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH FOLATE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3tqa:A (ILE3) to (THR64) STRUCTURE OF THE DIHYDROFOLATE REDUCTASE (FOLA) FROM COXIELLA BURNETII IN COMPLEX WITH NADPH | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
2e0z:B (ILE214) to (LEU286) CRYSTAL STRUCTURE OF VIRUS-LIKE PARTICLE FROM PYROCOCCUS FURIOSUS | VIRUS-LIKE PARTICLE, VIRUS, BACTERIOPHAGE, HK97, T4, VIRUS LIKE PARTICLE
2e0z:C (ILE214) to (THR285) CRYSTAL STRUCTURE OF VIRUS-LIKE PARTICLE FROM PYROCOCCUS FURIOSUS | VIRUS-LIKE PARTICLE, VIRUS, BACTERIOPHAGE, HK97, T4, VIRUS LIKE PARTICLE
1qzf:A (GLU3) to (SER76) CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE
1qzf:B (GLU3) to (SER76) CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE
1qzf:C (GLU3) to (SER76) CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE
1qzf:D (GLU3) to (SER76) CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE
1qzf:E (GLU3) to (SER76) CRYSTAL STRUCTURE OF DHFR-TS FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, OXIDOREDUCTASE, TRANSFERASE
3hbb:A (PHE23) to (LEU99) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hbb:B (PHE23) to (LEU99) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hbb:C (PHE23) to (SER100) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hbb:D (PHE23) to (LEU99) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hj3:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT | TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE
3hj3:B (ILE19) to (ILE75) CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT | TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE
3hj3:D (SER17) to (ILE75) CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT | TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE
1ra1:A (ILE14) to (LEU62) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1ra2:A (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1ra3:A (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1ra8:A (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2- MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1ra9:A (ILE14) to (LEU62) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rb2:B (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rb3:A (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rb3:B (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rd7:A (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rd7:B (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1re7:A (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1re7:B (ILE14) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rf7:A (MET1) to (SER63) STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rh3:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
4kak:A (SER3) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDINE-4-YL)PHENYL]BUT-1- YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kak:B (GLY2) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDINE-4-YL)PHENYL]BUT-1- YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kbn:A (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3-(3,5- PYRIMIDINE)]-PHENYL-PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2,4DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kbn:B (ILE16) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3-(3,5- PYRIMIDINE)]-PHENYL-PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2,4DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kd7:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5(PYRIDINE-4-YL)PHENYL]PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2, 4-DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kd7:B (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5(PYRIDINE-4-YL)PHENYL]PROP-1-YN-1-YL}-6-ETHYL-PYRIMIDINE-2, 4-DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4keb:A (ILE16) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]BUT-1-YN-1-YL}6-ETHYLPYRIMIDINE-2,4- DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4keb:B (GLY2) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]BUT-1-YN-1-YL}6-ETHYLPYRIMIDINE-2,4- DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE, NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kfj:A (ILE16) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]PROP-1-YN-1-YL}6-ETHYLPRIMIDINE-2,4- DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kfj:B (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]PROP-1-YN-1-YL}6-ETHYLPRIMIDINE-2,4- DIAMINE | OXIDOREDUCTASE, 5,6,7,8-TETRAHYDROFOLATE; NADP+, HYDRIDE SHIFT, CYTOSOL, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
1rx1:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx2:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx3:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx5:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE | OXIDO-REDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1rx6:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) | OXIDO-REDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1rx8:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2'- MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDO-REDUCTASE
1rx9:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
4kjj:A (MET1) to (SER63) CRYOGENIC WT DHFR | ROSSMANN FOLD, OXIDOREDUCTASE
4kjk:A (MET1) to (SER63) ROOM TEMPERATURE WT DHFR | ROSSMANN FOLD, OXIDOREDUCTASE
4kjl:A (MET1) to (SER64) ROOM TEMPERATURE N23PPS148A DHFR | ROSSMANN FOLD, OXIDOREDUCTASE
4klx:A (ILE14) to (LEU65) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN AN OPEN CONFORMATION. | REDUCTASE, OXIDOREDUCTASE
4klx:B (VAL2) to (LEU65) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN AN OPEN CONFORMATION. | REDUCTASE, OXIDOREDUCTASE
4km0:A (ILE14) to (LEU65) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PYRIMETHAMINE | REDUCTASE, OXIDOREDUCTASE
4km0:B (SER-1) to (LEU65) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PYRIMETHAMINE | REDUCTASE, OXIDOREDUCTASE
4km2:B (VAL2) to (LEU65) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN AN OPEN CONFORMATION IN COMPLEX WITH TRIMETHOPRIM | REDUCTASE, OXIDOREDUCTASE
1s3v:A (LEU4) to (SER76) STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY | DIHYDROFOLATE REDUCTASE, INHIBITOR, STEREOCHEMISTRY, OXIDOREDUCTASE
1s3w:A (LEU4) to (SER76) STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOALTES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY | DIHYDROFOLATE REDUCTASE, INHIBITOR COMPLEX, STEREOCHEMISTRY, OXIDOREDUCTASE
1s3y:A (SER6) to (THR81) STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY | PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE, INHIBITORS, STEREOCHEMISTRY, OXIDOREDUCTASE
4kne:A (ILE14) to (SER66) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CYCLOGUANIL | REDUCTASE, OXIDOREDUCTASE
4kne:B (ILE14) to (LEU65) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CYCLOGUANIL | REDUCTASE, OXIDOREDUCTASE
1sej:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:B (VAL6) to (ILE75) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:C (VAL6) to (ILE75) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:D (VAL6) to (ILE75) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:E (VAL6) to (ILE75) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2fzi:A (SER6) to (THR81) NEW INSIGHTS INTO DHFR INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES | DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM DERIVATIVES, RING STACKING INTERACTIONS, OXIDOREDUCTASE
2fzj:A (PRO3) to (SER76) NEW INSIGHTS INTO DHFR INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES | DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM DERIVATIVES, RING STACKING INTERACTIONS, OXIDOREDUCTASE
3vco:A (SER-1) to (SER73) SCHISTOSOMA MANSONI DIHYDROFOLATE REDUCTASE | REDUCTASE, OXIDOREDUCTASE
4ky4:A (PRO4) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:B (PRO4) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:C (PRO4) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:D (LYS3) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:E (PRO4) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:F (PRO4) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:G (PRO4) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:H (PRO4) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky8:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:B (VAL6) to (SER76) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:C (VAL6) to (SER76) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:D (VAL6) to (SER76) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:E (VAL6) to (SER76) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
3i8a:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS H30N, F98Y DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6- ETHYLPYRIMIDINE (UCP120B) | NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4kya:B (PRO4) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:C (PRO4) to (SER103) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:D (LYS3) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:E (PRO4) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:F (PRO4) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:H (PRO4) to (VAL102) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
3ia5:A (VAL3) to (SER64) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) | DHFR DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
3ia5:B (VAL3) to (SER64) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) | DHFR DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
2w3a:B (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
2w3b:A (GLY2) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5- METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686) | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
2w3b:B (ILE16) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5- METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686) | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
2w3m:A (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
2w3m:B (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
2w3v:A (VAL6) to (SER70) MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
2w3w:A (ILE18) to (SER70) MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5- METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686) | NONCLASSICAL ANTIFOLATES, ONE-CARBON METABOLISM, LIPOPHILIC ANTIFOLATES, NADP, REDUCTASE, OXIDOREDUCTASE
4lae:X (LEU3) to (THR64) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | DHFR, PROTEIN-INHIBITOR COMPLEX, FOLATE, NADPH, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4lag:X (LEU3) to (THR64) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | PROTEIN-INHIBITOR COMPLEX, FOLATE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4lah:X (LEU3) to (THR64) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | DHFR, PROTEIN-INHIBITOR COMPLEX, FOLATE, NADPH, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
1tdr:A (MET1) to (SER63) EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
1tdr:B (ILE14) to (SER63) EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE
4lek:X (LEU3) to (THR64) STRUCTURE-BASED DESIGN OF NEW DIHYDROFOLATE REDUCTASE ANTIBACTERIAL AGENTS: 7-(BENZIMIDAZOL-1-YL)-2,4-DIAMINOQUINAZOLINES | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3inv:A (PHE23) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH, DUMP AND C-448 ANTIFOLATE | DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE-TRANSFERASE COMPLEX
3inv:B (PHE23) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH, DUMP AND C-448 ANTIFOLATE | DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE-TRANSFERASE COMPLEX
1hfp:A (LEU4) to (SER76) COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE | OXIDOREDUCTASE, ONE-CARBON METABOLISM
2w9s:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9s:B (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9s:C (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9s:D (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9s:E (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9s:F (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR IN COMPLEX WITH TRIMETHOPRIM | ANTIBIOTIC RESISTANCE, DHFR, NADP, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9t:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR | ANTIBIOTIC RESISTANCE, STAPHYLOCOCCUS AUREUS, DHFR, NADP, PLASMID, TRIMETHOPRIM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
2w9t:B (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS S1:DHFR | ANTIBIOTIC RESISTANCE, STAPHYLOCOCCUS AUREUS, DHFR, NADP, PLASMID, TRIMETHOPRIM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE, ONE-CARBON METABOLISM, METHOTREXATE RESISTANCE
3irm:A (SER24) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irm:D (PHE23) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:A (PHE23) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:B (PHE23) to (SER100) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:C (ALA19) to (SER100) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:D (PHE23) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3iro:B (PHE23) to (LEU99) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3iro:C (PHE23) to (SER100) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3ix9:A (ILE5) to (THR67) CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT | CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE
3ix9:B (ILE5) to (THR67) CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE DIHYDROFOLATE REDUCTASE - SP9 MUTANT | CENTRAL BETA SHEET SURROUNDED BY 4 ALPHA HELICES, OXIDOREDUCTASE
1u70:A (PRO3) to (SER76) UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE | VARIANT DHFR MOUSE, HUMAN, OXIDOREDUCTASE
4m6l:A (LEU4) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE (DHFR) BOUND TO NADP+ AND 5,10-DIDEAZATETRAHYDROFOLIC ACID | ROSSMANN FOLD, NADPH BINDING, FOLATE BINDING, OXIDOREDUCTASE
4m6j:A (LEU4) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE (DHFR) BOUND TO NADPH | ROSSMANN FOLD, NADPH BINDING, FOLATE BINDING, OXIDOREDUCTASE
4m6k:A (LEU4) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE (DHFR) BOUND TO NADP+ AND FOLATE | ROSSMANN FOLD, NADPH BINDING, FOLATE BINDING, OXIDOREDUCTASE
4m7u:A (GLN-1) to (THR64) DIHYDROFOLATE REDUCTASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH NADP(H) | OXIDOREDUCTASE, REDUCTION OF DIHYDROFOLATE TO TETRAHYDROFOLATE
4m7v:A (LEU2) to (THR64) DIHYDROFOLATE REDUCTASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH NADP(H)AND RAB-PROPYL | OXIDOREDUCTASE, REDUCTION OF DIHYDROFOLATE TO TETRAHYDROFOLATE
2inq:A (MET1) to (SER63) NEUTRON CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BOUND TO THE ANTI-CANCER DRUG, METHOTREXATE | NEUTRON STRUCTURE; DEUTERIUM EXCHANGE; PSEUDO-ROSSMAN FOLD; NUCLEOTIDE BINDING DOMAIN; CHEMOTHERAPY, OXIDOREDUCTASE
2inq:B (ILE14) to (SER63) NEUTRON CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BOUND TO THE ANTI-CANCER DRUG, METHOTREXATE | NEUTRON STRUCTURE; DEUTERIUM EXCHANGE; PSEUDO-ROSSMAN FOLD; NUCLEOTIDE BINDING DOMAIN; CHEMOTHERAPY, OXIDOREDUCTASE
1jol:A (MET1) to (SER63) THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE | METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1jol:B (ILE14) to (SER63) THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE | METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1k4p:A (ASN38) to (VAL83) CRYSTAL STRUCTURE OF 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE IN COMPLEX WITH ZINC IONS | DIHYDROXYBUTANONE PHOSPHATE SYNTHASE, RIBOFLAVIN BIOSYNTHESIS, ANTIMICROBIAL TARGET, STRUCTURE-BASED DESIGN, ISOMERASE
2jyb:A (GLU2) to (MET64) BINARY HVDHFR1:FOLATE COMPLEX | DHFR, HALOPHILIC, FOLATE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
3zpg:A (TYR152) to (LEU229) ACINETOBACTER BAUMANNII RIBD, FORM 2 | REDUCTASE, DEAMINASE, HYDROLASE
2lf1:A (THR1) to (THR63) SOLUTION STRUCTURE OF L. CASEI DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH, 30 STRUCTURES | OXIDOREDUCTASE, DHFR, POSITIVE COOPERATIVITY, PROTEIN-LIGAND INTERACTIONS
1klk:A (SER6) to (THR81) CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH | STRUCTURE-BASED DESIGN, ANTIFOLATE, AIDS, PROTEIN-INHIBITOR COMPLEX, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
1kms:A (SER3) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3- D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE | OXIDOREDUCTASE, ANTIPARASITIC DRUGS, REDUCTASE, LIPOPHILIC ANTIFOLATES
1kmv:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)- 6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5- METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE | OXIDOREDUCTASE, ANTIPARASITIC DRUGS, REDUCTASE, LIPOPHILIC ANTIFOLATES
4nx6:A (MET1) to (SER63) SINGLE ROOM TEMPERATURE MODEL OF DHFR | FOLATE METABOLISM, OXIDOREDUCTASE
4nx7:A (MET1) to (SER63) SINGLE CRYOGENIC TEMPERATURE MODEL OF DHFR | FOLATE METABOLISM, OXIDOREDUCTASE
5cc9:A (MET1) to (SER63) L28F E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE | FOLATE METABOLISM, OXIDOREDUCTASE
5ccc:A (MET1) to (SER63) WILD-TYPE E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE | FOLATE METABOLISM, OXIDOREDUCTASE
3jw3:A (VAL3) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (F96I) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jw3:B (VAL3) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (F96I) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwc:A (ARG2) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwc:B (ARG2) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwf:A (ARG2) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (R)-2,4-DIAMINO-5-(3-HYDROXY-3-(3, 4,5-TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP113A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwf:B (ARG2) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS (Y102F) DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (R)-2,4-DIAMINO-5-(3-HYDROXY-3-(3, 4,5-TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP113A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwm:A (VAL3) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (S)-2,4-DIAMINO-5-(3-METHOXY-3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP114A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jwm:B (VAL3) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (S)-2,4-DIAMINO-5-(3-METHOXY-3-(3,4,5- TRIMETHOXYPHENYL)PROP-1-YNYL)-6-METHYLPYRIMIDINE (UCP114A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
1lud:A (THR1) to (THR63) SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES | DHFR, INHIBITOR/ENZYME COMPLEX, OXIDOREDUCTASE
1lw3:A (THR280) to (ASP352) CRYSTAL STRUCTURE OF MYOTUBULARIN-RELATED PROTEIN 2 COMPLEXED WITH PHOSPHATE | PROTEIN-PHOSPHATE COMPLEX, HYDROLASE
1ly3:A (SER6) to (THR81) ANALYSIS OF QUINAZOLINE AND PYRIDOPYRIMIDINE N9-C10 REVERSED BRIDGE ANTIFOLATES IN COMPLEX WITH NADP+ AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE | PCDHFR REVERSED BRIDGE ANTIFOLATES, OXIDOREDUCTASE
2o7p:B (TYR148) to (ILE232) THE CRYSTAL STRUCTURE OF RIBD FROM ESCHERICHIA COLI IN COMPLEX WITH THE OXIDISED NADP+ COFACTOR IN THE ACTIVE SITE OF THE REDUCTASE DOMAIN | NADP+ COMPLEX, ALPHA AND BETA CLASS WITH MAINLY PARALLELL BETA STRANDS, STRUCTURAL GENOMICS, HTP-PROTEIN ESCHERICHIA COLI, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, HYDROLASE, OXIDOREDUCTASE
4or7:A (MET1) to (SER63) KLEBSIELLA PNEUMONIAE DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-{3-[3-(PYRIMIDIN-5-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4- DIAMINE | 5,6,7,8-TETRAHYDROFOLATE; 7,8-DIHYDROFOLATE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
1m74:A (LEU352) to (THR391) CRYSTAL STRUCTURE OF MG-ADP-BOUND SECA FROM BACILLUS SUBTILIS | PROTEIN TRANSLOCATION; ATPASE; TRANSMEMBRANE TRANSPORT; HELICASE FAMILY STRUCTURE; MECHANOCHEMISTY, PROTEIN TRANSPORT
4osg:A (MET1) to (ILE62) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:B (MET1) to (SER63) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:C (MET1) to (ILE62) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4osg:D (MET1) to (ILE62) KLEBSIELLA PNEUMONIAE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3R)-3-[3- METHOXYL-5-(PYRIDINE-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, HYDRIDE SHIFT, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
1m7r:B (THR280) to (ASP352) CRYSTAL STRUCTURE OF MYOTUBULARIN-RELATED PROTEIN-2 (MTMR2) COMPLEXED WITH PHOSPHATE | PROTEIN-PHOSPHATE COMPLEX, HYDROLASE
3kfy:A (ILE2) to (SER63) DYNAMIC SWITCHING AND PARTIAL OCCUPANCIES OF A SMALL MOLECULE INHIBITOR COMPLEX OF DHFR | SMALL MOLECULE INHIBITOR, DYNAMICS, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE
3kjs:A (PHE23) to (LEU99) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
3kjs:B (ALA19) to (LEU99) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
3kjs:C (ALA19) to (LEU99) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
3kjs:D (PHE23) to (LEU99) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
4p3q:A (ILE14) to (SER63) ROOM-TEMPERATURE WT DHFR, TIME-AVERAGED ENSEMBLE | ROSSMANN FOLD, OXIDOREDUCTASE
4p3r:A (ILE2) to (SER63) CRYOGENIC WT DHFR, TIME-AVERAGED ENSEMBLE | ROSSMANN FOLD, OXIDOREDUCTASE
2zza:A (VAL3) to (LEU63) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE COMPLEX WITH NADP+ AND FOLATE | DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP, DEEP-SEA, HIGH PRESSURE, LOW TEMPERATURE, MORITELLA PROFUNDA, PIEZOPHILIC, PSYCHROPHILIC, PSYCHROPIEZOPHILIC, OXIDOREDUCTASE
2zza:B (VAL3) to (LEU63) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE COMPLEX WITH NADP+ AND FOLATE | DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP, DEEP-SEA, HIGH PRESSURE, LOW TEMPERATURE, MORITELLA PROFUNDA, PIEZOPHILIC, PSYCHROPHILIC, PSYCHROPIEZOPHILIC, OXIDOREDUCTASE
4p68:A (ILE2) to (LEU62) ELECTROSTATICS OF ACTIVE SITE MICROENVIRONMENTS FOR E. COLI DHFR | ELECTROSTATICS, CATALYSIS, OXIDOREDUCTASE, DHFR
1yho:A (SER3) to (SER76) SOLUTION STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 25 STRUCTURES | DHFR, INHIBITOR/ENZYME COMPLEX, OXIDOREDUCTASE
4pdj:A (MET1) to (SER63) NEUTRON CRYSTAL STRUCTURE OF E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NADP+ | ALPHA BETA ALPHA SANDWICH, OXIDOREDUCTASE
3ky8:B (ASN3) to (SER75) CRYSTAL STRUCTURE OF PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN (YP_001092907.1) FROM SHEWANELLA SP. PV-4 AT 2.12 A RESOLUTION | PUTATIVE RIBOFLAVIN BIOSYNTHESIS PROTEIN, STRUCTURAL GENOMICS, JOINT CENTER FOR STRUCTURAL GENOMICS, JCSG, PROTEIN STRUCTURE INITIATIVE, PSI-2, BIOSYNTHETIC PROTEIN
5dfr:A (MET1) to (SER63) CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING | OXIDO-REDUCTASE, OXIDOREDUCTASE
3l3r:A (LEU4) to (SER76) STRUCTURAL, COMPUTATIONAL AND KINETIC DATA FOR ANTIFOLATE INTERACTIONS AGAINST PNEUMOCYSTIS JIROVECII, PNEUMOCYSTIS CARINII AND HUMAN DIHYDROFOLATE REDUCTASE AND THEIR ACTIVE SITE MUTANTS | DIHYDROFOLATE REDUCTASE, ANTIFOLATE, ACTIVE SITE MUTANTS, NADP, ONE- CARBON METABOLISM, OXIDOREDUCTASE
4pst:A (MET1) to (LEU62) MULTICONFORMER MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 277 K | REDUCTASE, OXIDOREDUCTASE
4psy:A (MET1) to (SER63) 100K CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE | REDUCTASE, OXIDOREDUCTASE
4ptj:A (MET1) to (SER63) ENSEMBLE MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 277K | ROSSMANN FOLD, OXIDOREDUCTASE
3lg4:A (THR1) to (THR63) STAPHYLOCOCCUS AUREUS V31Y, F92I MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-[(3S)-3-(5-METHOXY-2',6'-DIMETHYLBIPHENYL- 3-YL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4-DIAMINE | OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
3lg4:B (THR1) to (THR63) STAPHYLOCOCCUS AUREUS V31Y, F92I MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-[(3S)-3-(5-METHOXY-2',6'-DIMETHYLBIPHENYL- 3-YL)BUT-1-YN-1-YL]-6-METHYLPYRIMIDINE-2,4-DIAMINE | OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
1zdr:A (ILE2) to (THR63) DHFR FROM BACILLUS STEAROTHERMOPHILUS | DHFR, NADP, OXIDOREDUCTASE
1zdr:B (ILE2) to (THR63) DHFR FROM BACILLUS STEAROTHERMOPHILUS | DHFR, NADP, OXIDOREDUCTASE
4q0d:E (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:B (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:C (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:D (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
5dxv:A (VAL30) to (LEU79) CRYSTAL STRUCTURE OF RETHREADED DHFR | PROTEIN DESIGN, DE NOVO PROTEIN
5dxv:B (VAL30) to (SER80) CRYSTAL STRUCTURE OF RETHREADED DHFR | PROTEIN DESIGN, DE NOVO PROTEIN
1zsq:A (THR280) to (ASP352) CRYSTAL STRUCTURE OF MTMR2 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE | PROTEIN-PHOSPHOLIPID COMPLEX, HYDROLASE
4q67:A (THR1) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH | OXIDOREDUCTASE
4q6a:A (THR1) to (THR63) STAPHYLOCOCCUS AUREUS V31L, F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH | OXIDOREDUCTASE
5e8q:B (ILE14) to (SER63) CRYSTAL STRUCTURE OF DHFR IN 20% ISOPROPANOL | DYNAMICS, OXIDOREDUCTASE
5e8q:A (MET1) to (SER63) CRYSTAL STRUCTURE OF DHFR IN 20% ISOPROPANOL | DYNAMICS, OXIDOREDUCTASE
3m09:A (LEU2) to (THR63) F98Y TMP-RESISTANT DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS WITH INHIBITOR RAB1 | FOLATE, DHFR, ANTIMICROBIAL, ANTIBIOTIC RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5eaj:B (ILE14) to (SER63) CRYSTAL STRUCTURE OF DHFR IN 0% ISOPROPANOL | DYNAMICS, OXIDOREDUCTASE
5eaj:A (MET1) to (SER63) CRYSTAL STRUCTURE OF DHFR IN 0% ISOPROPANOL | DYNAMICS, OXIDOREDUCTASE
4qi9:A (ILE3) to (SER64) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qi9:B (ILE3) to (SER64) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qi9:C (ILE3) to (SER64) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEXED WITH METHOTREXATE | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, ALPHA BETA FOLD, NIAID, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4qjz:D (ILE19) to (THR81) PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH NADPH AND THE INHIBITOR 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL) PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE) | ROSSMAN FOLD, HYDROLASE, NADPH AND FOLATE INHIBITOR, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4qle:A (ALA14) to (LEU62) CRYSTAL STRUCTURE OF I14A DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+ | DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE
4qle:B (ALA14) to (LEU62) CRYSTAL STRUCTURE OF I14A DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+ | DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE
4qlf:A (MET1) to (LEU62) CRYSTAL STRUCTURE OF I14G DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+ | DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE
4qlg:A (VAL14) to (LEU62) CRYSTAL STRUCTURE OF I14V DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+ | DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE
4qlg:B (VAL14) to (SER63) CRYSTAL STRUCTURE OF I14V DHFR MUTANT COMPLEXED WITH FOLATE AND NADP+ | DIHYDROFOLATE-REDUCTASE LIKE FOLD/ALPHA AND BETA PROTEINS (A/B), OXIDOREDUCTASE ACTIVITY, NADP(H) BINDING, OXIDOREDUCTASE
4rgc:A (ILE14) to (SER63) 277K CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE | REDUCTASE, OXIDOREDUCTASE
3cl9:A (ALA19) to (SER100) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH MTX | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP, MTX AND DUMP, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE- TRANSFERASE COMPLEX
3clb:A (ALA22) to (SER100) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3clb:B (PHE23) to (LEU99) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3clb:D (PHE23) to (LEU99) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3ntz:A (LEU4) to (SER76) DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTAL STRUCTURES OF NOVEL CLASSICAL 6,5,6-TRICYCLICBENZO[4,5]THIENO[2,3-D]PYRIMIDINES AS DUAL THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE INHIBITORS | DIHYDROFOLATE REDUCTASE, CYCLIZED INHIBITORS, OXIDOREDUCTASE HDHFR- 263-NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3nxx:A (LEU4) to (SER76) PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO-2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE | CHIRAL MIXTURES PREFERENTIAL SELECTION, OXIDOREDUCTASE
3nxy:A (LEU4) to (SER76) PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALERNATE BINDING MODES OBSERVED FRO THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE | CHIRAL MIXTURES PREFERENTIAL BINDING, OXIDOREDUCTASE
3nz6:X (SER6) to (THR81) STRUCTURAL ANALYSIS OF PNEUMOCYSTIS CARINII AND HUMAN DHFR COMPLEXES WITH NADPH AND A SERIES OF FIVE POTENT 5-(OMEGA-CARBOXY(ALKYLOXY) PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES | PNEUMOCYSTIS CARINII DHFR INHIBITOR COMPLEXES, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3nz9:X (ILE19) to (THR81) STRUCTURAL ANALYSIS OF PNEUMOCYSTIS CARINII AND HUMAN DHFR COMPLEXES WITH NADPH AND A SERIES OF FIVE POTENT 5-(OMEGA-CARBOXY(ALKYLOXY) PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES | PNEUMOCYSTIS CARINII DHFR INHIBITOR COMPLEXES, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3oaf:A (LEU4) to (SER76) STRUCTURAL AND KINETIC DATA FOR ANTIFOLATE INTERACTIONS AGAINST PNEUMOCYSTIS JIROVECII, PNEUMOCYSTIS CARINII AND HUMAN DIHYDROFOLATE REDUCTASE AND THIER ACTIVE SITE MUTANTS | HDHFR INHIBITOR COMPLEXES, OXIDOREDUCTASE-INHIBITOR COMPLEX
3och:A (MET1) to (SER63) CHEMICALLY SELF-ASSEMBLED ANTIBODY NANORINGS (CSANS): DESIGN AND CHARACTERIZATION OF AN ANTI-CD3 IGM BIOMIMETIC | OXIDOREDUCTASE
3och:B (ILE214) to (SER263) CHEMICALLY SELF-ASSEMBLED ANTIBODY NANORINGS (CSANS): DESIGN AND CHARACTERIZATION OF AN ANTI-CD3 IGM BIOMIMETIC | OXIDOREDUCTASE
3dat:A (ARG13) to (THR64) CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE | DUAL-SITE INHIBITION, OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, ADENINE NUCLEOTIDE BINDING DOMAIN
3dau:A (ILE14) to (LEU62) CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, ADENINE NUCLEOTIDE BINDING DOMAIN, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE- CARBON METABOLISM, TRIMETHOPRIM RESISTANCE
3dl5:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl5:B (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl5:C (GLU3) to (ILE75) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl5:D (VAL6) to (ILE75) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl5:E (VAL6) to (SER76) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl6:A (VAL6) to (SER76) CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE
3dl6:B (GLU3) to (SER76) CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE
3dl6:C (VAL10) to (SER76) CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE
3dl6:D (VAL9) to (SER76) CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE
3drc:A (MET1) to (SER63) INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS | OXIDOREDUCTASE
3drc:B (ILE14) to (SER63) INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS | OXIDOREDUCTASE
4ddr:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND P218 | ANTIFOLATE, NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4dfr:A (MET1) to (SER63) CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE | OXIDO-REDUCTASE
4dfr:B (ILE14) to (SER63) CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE | OXIDO-REDUCTASE
5hi6:A (ILE3) to (SER64) THE HIGH RESOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM YERSINIA PESTIS COMPLEX WITH METHOTREXATE AS CLOSED FORM | STRUCTURAL GENOMICS, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES, CSGID, DIHYDROFOLATE REDUCTASE, YERSINIA PESTIS, OXIDOREDUCTASE
3e0b:A (ARG2) to (THR64) BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2, 4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
3e0b:B (ARG2) to (THR64) BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2, 4-DIAMINO-5-(3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
4eck:A (LYS3) to (VAL102) CRYSTAL STRUCTURE OF THE TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, TRANSFERASE, OXIDOREDUCTASE
4eck:B (PRO26) to (SER103) CRYSTAL STRUCTURE OF THE TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, TRANSFERASE, OXIDOREDUCTASE
4eig:A (MET1) to (SER63) CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR | NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4eiz:A (MET1) to (SER63) STRUCTURE OF NB113 BOUND TO APODHFR | NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4eiz:B (MET1) to (SER63) STRUCTURE OF NB113 BOUND TO APODHFR | NADP BINDING, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4ej1:A (MET1) to (SER63) BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX | FOLATE, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4ej1:B (MET1) to (SER63) BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX | FOLATE, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
4ele:A (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:B (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:C (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:D (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:E (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:F (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:G (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4ele:H (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:A (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:H (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:C (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:B (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:G (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:F (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:D (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elh:E (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3qfx:A (PHE29) to (LEU105) TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE PYRIMETHAMINE COMPLEX | PYRIMETHAMINE, ANTIFOLATE RESISTANCE, TRYPANOSOME, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3qfx:B (PHE29) to (LEU105) TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE PYRIMETHAMINE COMPLEX | PYRIMETHAMINE, ANTIFOLATE RESISTANCE, TRYPANOSOME, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3ql0:A (ILE14) to (SER63) CRYSTAL STRUCTURE OF N23PP/S148A MUTANT OF E. COLI DIHYDROFOLATE REDUCTASE | ROSSMANN FOLD, OXIDOREDUCTASE
3ql3:A (MET1) to (SER63) RE-REFINED COORDINATES FOR PDB ENTRY 1RX2 | ROSSMANN FOLD, DIHYDROFOLATE, TETRAHYDROFOLATE, NADPH, COFACTOR, OXIDOREDUCTASE
3qlw:A (LEU17) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- [3-(2,5-DIMETHOXYPHENYL)PROP-1-YN-1-YL]-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP120B) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3qlw:B (VAL6) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- [3-(2,5-DIMETHOXYPHENYL)PROP-1-YN-1-YL]-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP120B) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, MODELS, MOLECULAR STRUCTURE, STRUCTURE-ACTIVITY RELATIONSHIP, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4fhb:A (ILE14) to (LEU62) ENHANCING DHFR CATALYSIS BY BINDING OF AN ALLOSTERIC REGULATOR NANOBODY (NB179) | NANOBODY, DIHYDROFOLATE REDUCTASE, ALLOSTERIC ACTIVATOR, REDUCTASE, OXIDOREDUCTASE-PROTEIN BINDING COMPLEX
3qyl:A (ILE2) to (SER63) SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE
3qyo:A (MET1) to (SER63) SENSITIVITY OF RECEPTOR INTERNAL MOTIONS TO LIGAND BINDING AFFINITY AND KINETIC OFF-RATE | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE
5ja3:A (ILE14) to (LEU65) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106) | DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE
5ja3:B (ILE14) to (SER66) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106) | DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE
5ja3:C (ILE14) to (SER66) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106) | DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE
5ja3:D (VAL2) to (SER66) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1- YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106) | DHFR, ANTIFOLATE, FOLATE PATHWAY, OXIDOREDUCTASE
4g3m:D (VAL148) to (LEU219) COMPLEX STRUCTURE OF BACILLUS SUBTILIS RIBG: THE DEAMINATION PROCESS IN RIBOFLAVIN BIOSYNTHESIS | ALPHA/BETA/ALPHA, DEAMINASE DOMAIN, REDUCTASE DOMAIN, HYDROLASE, OXIDOREDUCTASE
4g95:A (LEU4) to (SER76) HDHFR-OAG BINARY COMPLEX | DIHYDROFOLATE REDUCTASE, ANTIFOLATE, OXIDOREDUCTASE
4gh8:A (MET1) to (SER67) CRYSTAL STRUCTURE OF A 'HUMANIZED' E. COLI DIHYDROFOLATE REDUCTASE | TETRAHYDROFOLATE, ENZYME CATALYSIS, EVOLUTION, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE
5t0l:A (PRO4) to (SER103) CRYSTAL STRUCTURE OF TOXOPLASMA GONDII TS-DHFR COMPLEXED WITH NADPH, DUMP, PDDF AND 5-(4-(3,4-DICHLOROPHENYL)PIPERAZIN-1-YL)PYRIMIDINE-2, 4-DIAMINE (TRC-15) | TOXOPLASMA GONDII, DHFR, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5t0l:B (PRO4) to (SER103) CRYSTAL STRUCTURE OF TOXOPLASMA GONDII TS-DHFR COMPLEXED WITH NADPH, DUMP, PDDF AND 5-(4-(3,4-DICHLOROPHENYL)PIPERAZIN-1-YL)PYRIMIDINE-2, 4-DIAMINE (TRC-15) | TOXOPLASMA GONDII, DHFR, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
6dfr:A (MET1) to (SER63) CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE | OXIDO-REDUCTASE
7dfr:A (MET1) to (LEU62) CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE | OXIDO-REDUCTASE
2ano:A (MET1) to (LEU62) CRYSTAL STRUCTURE OF E.COLI DIHYDROFOLATE REDUCTASE IN COMPLEX WITH NADPH AND THE INHIBITOR MS-SH08-17 | DHFR, PROTEIN INHIBITOR COMPLEX, OXIDOREDUCTASE
4h96:A (LEU17) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4h96:B (VAL6) to (SER78) CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5- {3-[3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHOXYPHENYL]PROP-1-YN-1- YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE (UCP1018) | ANTIFUNGAL AGENTS, CANDIDA ALBICANS, DRUG DESIGN, ENZYME INHIBITORS, FUNGAL PROTEINS, TETRAHYDROFOLATE DEHYDROGENASE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3f0v:X (THR1) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(2,6-DIMETHYLPHENYL) PHENYL)BUT-1-YNYL]-6-METHYLPYRIMIDINE | OXIDOREDUCTASE
3f0x:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-5-(3,5-DIMETHYLPHENYL) PHENYL)BUT-1-YNYL]-6-METHYLPYRIMIDINE | OXIDOREDUCTASE
4x5j:A (ILE14) to (LEU62) ECDHFR COMPLEXED WITH FOLATE AND NADP+ AT 750 MPA | OXIDOREDUCTASE
3s7a:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE BINARY COMPLEX WITH PT684 | SINGLE POLYPEPTIDE CHAIN, REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4i13:A (MET1) to (SER63) NANOBODY CA1697 BINDING TO THE DHFR.FOLATE BINARY COMPLEX | ALPHA/BETA FOLD, IMMUNOGLOBULIN FOLD, REDUCTASE, NADPH, FOLATE DERIVATIVES, REDUCTION, OXIDOREDUCTASE-IMMUNE SYSTEM COMPLEX
3sgy:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3sgy:B (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1- YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) | OXIDOREDUCTASE, NADP, NADPH, ONE-CARBON METABOLISM, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
3fqo:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(2,5-DIMETHOXYPHENYL)PROP-1-YNYL]-6- ETHYLPYRIMIDINE (UCP120B) | OXIDOREDUCTASE
3fqv:A (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS F98Y MUTANT DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-[3-(3-METHOXY-4-PHENYLPHENYL)BUT-1- YNYL]-6-METHYLPYRIMIDINE | OXIDOREDUCTASE
3fra:X (LEU2) to (THR63) STAPHYLOCOCCUS AUREUS F98Y DHFR COMPLEXED WITH ICLAPRIM | DHFR, OXIDOREDUCTASE, NADP, ONE-CARBON METABOLISM
1d1g:A (LYS2) to (LEU63) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1d1g:B (LYS2) to (LEU63) DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA | DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
1ddr:A (MET1) to (SER63) MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA | OXIDO-REDUCTASE
1ddr:B (ILE14) to (SER63) MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA | OXIDO-REDUCTASE
1dds:A (MET1) to (SER63) MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE | OXIDO-REDUCTASE
1dds:B (ILE14) to (SER63) MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE | OXIDO-REDUCTASE
2qk8:A (VAL3) to (THR64) CRYSTAL STRUCTURE OF THE ANTHRAX DRUG TARGET, BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE | OXIDOREDUCTASE, METHOTREXATE, PTERIDINE BINDING, NUCLEOTIDE PHOSPHATE BINDING, PSEUDO-ROSSMAN FOLD
1dhf:A (ILE16) to (SER76) CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE | OXIDO-REDUCTASE
1dlr:A (LEU4) to (SER76) METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS | OXIDO-REDUCTASE
1drb:A (MET1) to (SER63) CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING | OXIDOREDUCTASE
1drb:B (ILE14) to (SER63) CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING | OXIDOREDUCTASE
1drf:A (LEU4) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE (CH-NH(D)-NAD OR NADP(A))
3gi2:A (LEU4) to (SER76) HUMAN DIHYDROFOLATE REDUCTASE Q35K MUTANT INHIBITOR COMPLEX | DIHYDROFOLATE REDUCTASE, FOLATE ENZYME, ACTIVE SITE MUTANTS, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE
4ixg:X (SER6) to (THR81) PCDHFR-268-K37S-N69F VARIANT | DIHYDROFOLATE REDUCTASE INHIBITOR TERNARY COMPLEX DOUBLE VARIANT, REDUCTASE, OXIDOREDUCTASE-INHIBITOR COMPLEX
2dhf:A (LEU4) to (SER76) CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE | OXIDO-REDUCTASE
2dhf:B (LEU4) to (SER76) CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE | OXIDO-REDUCTASE
1rc4:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rg7:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1rx4:A (MET1) to (SER63) DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10- DIDEAZATETRAHYDROFOLATE AND 2'-MONOPHOSPHOADENOSINE 5'- DIPHOSPHORIBOSE | OXIDO-REDUCTASE NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM, OXIDOREDUCTASE
1rx7:A (MET1) to (SER63) STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE | OXIDOREDUCTASE, NADP, TRIMETHOPRIM RESISTANCE, METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM
1s3u:A (LEU4) to (SER76) STRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY | DIHYDROFOLATE REDUCTASE, INHIBITOR COMPLEX, OXIDOREDUCTASE
2fzh:A (SER6) to (THR81) NEW INSIGHTS INTO DIHYDROFOLATE REDUCTASE INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES | DIHYDROFOLATE REDUCTASE, TRIMETHOPRIM DERIVATIVES, RING STACKING INTERACTIONS, OXIDOREDUCTASE
3ia4:A (ILE15) to (LEU63) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) | DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
3ia4:B (ILE15) to (LEU63) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) | DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
3ia4:C (VAL3) to (LEU63) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) | DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
3ia4:D (ILE15) to (LEU63) MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE (DHFR) IN COMPLEX WITH NADPH AND METHOTREXATE (MTX) | DHFR DIHYDROFOLATE REDUCTASE, NADPH, METHOTREXATE, OXIDOREDUCTASE
1hfr:A (LEU4) to (SER76) COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE | OXIDOREDUCTASE, ONE-CARBON METABOLISM
2h2q:A (PHE23) to (LEU99) CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND DUMP, OXIDOREDUCTASE, TRANSFERASE
2w9g:A (THR1) to (THR63) WILD-TYPE STAPHYLOCOCCUS AUREUS DHFR IN COMPLEX WITH NADPH AND TRIMETHOPRIM | OXIDOREDUCTASE, ONE-CARBON METABOLISM
2w9h:A (LEU2) to (THR63) WILD-TYPE STAPHYLOCOCCUS AUREUS DHFR IN COMPLEX WITH TRIMETHOPRIM | OXIDOREDUCTASE, ONE-CARBON METABOLISM
2hqp:A (THR1) to (HIS64) SOLUTION STRUCTURE OF L.CASEI DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH, 32 STRUCTURES | OXIDOREDUCTASE, DHFR
1u71:A (LEU4) to (SER76) UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE TERNARY CRYSTAL COMPLEXES WITH METHOTREXATE AND NADPH | HUMAN DHFR L22R VARIANT, OXIDOREDUCTASE
4m2x:A (VAL2) to (LEU65) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4m2x:C (ILE14) to (LEU65) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4m2x:E (ILE14) to (SER66) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4m2x:G (VAL2) to (LEU65) MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETREXATE (TMQ) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, REDUCTASE, NADPH BINDING, HYDRIDE TRANSFER, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
1jom:A (MET1) to (SER63) THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE | METHOTREXATE RESISTANCE, ONE-CARBON METABOLISM OXIDOREDUCTASE
3jvx:A (ARG2) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5-TRIMETHOXYPHENYL) PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3jvx:B (ARG2) to (THR64) CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4-DIAMINO-5-(3-(3,4,5-TRIMETHOXYPHENYL) PROP-1-YNYL)-6-ETHYLPYRIMIDINE (UCP120A) | OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3k74:A (MET1) to (SER63) DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY | IMMUNOGLOBULIN, PROTEIN-NANOBODY COMPLEX, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRIMETHOPRIM RESISTANCE
4om7:A (ILE669) to (LEU735) CRYSTAL STRUCTURE OF TIR DOMAIN OF TLR6 | TIR FOLD, PROTEIN INTERACTION, SIGNALING PROTEIN
1mvs:A (LEU4) to (SER76) ANALYSIS OF TWO POLYMORPHIC FORMS OF A PYRIDO[2,3- D]PYRIMIDINE N9-C10 REVERSE-BRIDGE ANTIFOLATE BINARY COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, HUMAN DHFR, ANTIFOLATE, N9-C10 REVERSE BRIDGE PYROLOPYRIMIDINE, OXIDOREDUCTASE
1mvt:A (LEU4) to (SER76) ANALYSIS OF TWO POLYMORPHIC FORMS OF A PYRIDO[2,3- D]PYRIMIDINE N9-C10 REVERSE-BRIDGE ANTIFOLATE BINARY COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, HUMAN DHFR, ANTIFOLATE, N9-C10 REVERSE BRIDGE PYROLOPYRIMIDINE, OXIDOREDUCTASE
4pss:A (MET1) to (SER63) MULTICONFORMER MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 100K | REDUCTASE, OXIDOREDUCTASE
4pth:A (MET1) to (SER63) ENSEMBLE MODEL FOR ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE AT 100K | ROSSMANN FOLD, OXIDOREDUCTASE
4q0e:A (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:B (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:C (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:D (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:E (VAL6) to (ILE75) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
1zvr:A (THR280) to (ASP352) CRYSTAL STRUCTURE OF MTMR2 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | PROTEIN-PHOSPHOINOSITIDE COMPLEX, HYDROLASE
3m08:A (LEU2) to (THR63) WILD TYPE DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS WITH INHIBITOR RAB1 | FOLATE, DHFR, ANTIMICROBIAL, ANTIBIOTIC RESISTANCE, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE', OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5ecc:A (LYS1) to (THR62) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(2- METHOXY-5-(PYRIDIN-4-YL)PHENYL)PROP-1-YN-1-YL)PYRIMIDINE-2,4-DIAMINE | OXIDOREDUCTASE, ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
5ecx:A (LYS1) to (THR62) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(6- (PYRIDIN-4-YL)BENZO[D][1,3]DIOXOL-4-YL)BUT-1-YN-1-YL)PYRIMIDINE-2,4- DIAMINE | ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
5ecx:B (LYS1) to (ARG63) KLEBSIELLA PNEUMONIAE DFRA1 COMPLEXED WITH NADPH AND 6-ETHYL-5-(3-(6- (PYRIDIN-4-YL)BENZO[D][1,3]DIOXOL-4-YL)BUT-1-YN-1-YL)PYRIMIDINE-2,4- DIAMINE | ANTIFOLATES, DFRA1, PLASMID BORNE RESISTANCE, OXIDOREDUCTASE- OXIDOREDUCTASE INHIBITOR COMPLEX
4qhv:A (LEU4) to (SER76) CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE AS COMPLEX WITH PYRIDOPYRIMIDINE 22 (N~6~-METHYL-N~6~-[4-(PROPAN-2-YL) PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE) | INHIBITOR BINDING, ROSSMAN FOLD, HYDROLASE, INHIBITOR, COFACTOR NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3nxr:A (LEU4) to (SER76) PERFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE | CHIRAL SELECTION E- Z-ISOMERS, OXIDOREDUCTASE
3nxv:A (LEU4) to (SER76) PREFERENTIAL SELECTION OF ISOMER BINDING FROM CHIRAL MIXTURES: ALTERNATE BINDING MODES OBSERVED FOR THE E- AND Z-ISOMERS OF A SERIES OF 5-SUBSTITUTED 2,4-DIAMINOFURO[2,3-D]PYRIMIDINES AS TERNARY COMPLEXES WITH NADPH AND HUMAN DIHYDROFOLATE REDUCTASE | CHIRAL MIXTURE, E-Z-ISOMERS, OXIDOREDUCTASE
4eil:A (PRO4) to (SER103) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:B (PRO4) to (SER103) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:C (PRO4) to (SER103) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:D (PRO4) to (SER103) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:E (PRO4) to (VAL102) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:F (PRO4) to (SER103) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:G (PRO4) to (VAL102) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:H (PRO4) to (VAL102) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4elf:A (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:B (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:C (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:D (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:E (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:F (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:G (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elf:H (VAL3) to (ARG65) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:A (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:H (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:C (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:B (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:G (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:F (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:D (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elb:E (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:A (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:B (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:C (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:D (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:E (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:F (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:G (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4elg:H (VAL3) to (THR64) STRUCTURE-ACTIVITY RELATIONSHIP GUIDES ENANTIOMERIC PREFERENCE AMONG POTENT INHIBITORS OF B. ANTHRACIS DIHYDROFOLATE REDUCTASE | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
4fgg:A (LEU2) to (THR63) S. AUREUS DIHYDROFOLATE REDUCTASE CO-CRYSTALLIZED WITH PROPYL-DAP ISOBUTENYL-DIHYDROPHTHALAZINE INHIBITOR | DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE-INHIBITOR COMPLEX
4fgh:A (VAL6) to (THR63) S. AUREUS DIHYDROFOLATE REDUCTASE CO-CRYSTALLIZED WITH ETHYL-DAP ISOBUTENYL-DIHYDROPHTHALAZINE INHIBITOR | OXIDOREDUCTASE-INHIBITOR COMPLEX
3r33:A (MET1) to (LEU62) EVIDENCE FOR DYNAMIC MOTION IN PROTEINS AS A MECHANISM FOR LIGAND DISSOCIATION | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE
3rg9:A (PHE29) to (SER106) TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE (TBDHFR) IN COMPLEX WITH WR99210 | TRYPANOSOMA BRUCEI, OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, WR99210, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX
3rg9:B (PHE29) to (SER106) TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE (TBDHFR) IN COMPLEX WITH WR99210 | TRYPANOSOMA BRUCEI, OXIDOREDUCTASE, DIHYDROFOLATE REDUCTASE, WR99210, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX