4wa9:B (ASN336) to (LEU387) THE CRYSTAL STRUCTURE OF HUMAN ABL1 WILD TYPE KINASE DOMAIN IN COMPLEX WITH AXITINIB | KINASE, KINASE INHIBITOR, AXITINIB, ACTIVATION LOOP, DFG-OUT, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4wbo:A (GLU288) to (ALA341) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH AMLEXANOX | G-PROTEIN-COUPLED RECEPTOR KINASE 1, AMLEXANOX, PHOSPHORYLATION, PROTEIN CONFORMATION, PROTEIN KINASE INHIBITORS, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4wbo:B (GLU288) to (ALA341) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH AMLEXANOX | G-PROTEIN-COUPLED RECEPTOR KINASE 1, AMLEXANOX, PHOSPHORYLATION, PROTEIN CONFORMATION, PROTEIN KINASE INHIBITORS, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4wbo:C (GLU288) to (ALA341) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH AMLEXANOX | G-PROTEIN-COUPLED RECEPTOR KINASE 1, AMLEXANOX, PHOSPHORYLATION, PROTEIN CONFORMATION, PROTEIN KINASE INHIBITORS, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4wbo:D (GLU288) to (LEU339) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH AMLEXANOX | G-PROTEIN-COUPLED RECEPTOR KINASE 1, AMLEXANOX, PHOSPHORYLATION, PROTEIN CONFORMATION, PROTEIN KINASE INHIBITORS, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2obj:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH INHIBITOR | PIM, PIM-1, PIM1, HUMAN PIM-1 KINASE, SERINE/THREONINE KINASE, KINASE INHIBITOR COMPLEX, PYRIDONE, KINASE INHIBITOR, TRANSFERASE
4gw8:A (GLN140) to (LEU192) HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND LEUCETTINE L41 | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE, CELL CYCLE, CELL MEMBRANE
3rp9:A (LEU156) to (VAL206) CRYSTAL STRUCTURE OF THE APO MAPK FROM TOXOPLASMA GONDII, 25.M01780 OR TGME49_007820 | STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3rps:A (THR129) to (PHE181) STRUCTURE OF HUMAN CK2ALPHA IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 3-(4,5,6,7-TETRABROMO-1H-BENZOTRIAZOL-1-YL)PROPAN-1-OL | EUKARYOTIC PROTEIN KINASE FOLD, ATP CK2BETA, PHOSPHORYLATION, CYTOPLASM NUCLEUS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rps:B (THR129) to (PHE181) STRUCTURE OF HUMAN CK2ALPHA IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 3-(4,5,6,7-TETRABROMO-1H-BENZOTRIAZOL-1-YL)PROPAN-1-OL | EUKARYOTIC PROTEIN KINASE FOLD, ATP CK2BETA, PHOSPHORYLATION, CYTOPLASM NUCLEUS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2oic:B (TRP285) to (SER336) CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH STAUROSPORINE | KINASE, TRANSFERASE
2oic:D (TRP285) to (GLU337) CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH STAUROSPORINE | KINASE, TRANSFERASE
2as0:A (ASP341) to (ARG396) CRYSTAL STRUCTURE OF PH1915 (APC 5817): A HYPOTHETICAL RNA METHYLTRANSFERASE | RNA METHYLTRANSFERASE, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, MIDWEST CENTER FOR STRUCTURAL GENOMICS, MCSG
2as0:B (GLN343) to (ARG396) CRYSTAL STRUCTURE OF PH1915 (APC 5817): A HYPOTHETICAL RNA METHYLTRANSFERASE | RNA METHYLTRANSFERASE, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, MIDWEST CENTER FOR STRUCTURAL GENOMICS, MCSG
2ayp:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHK1 WITH AN INDOL INHIBITOR | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
4wnp:A (LEU119) to (GLN173) STRUCTURE OF ULK1 BOUND TO A POTENT INHIBITOR | KINASE, AUTOPHAGY, INHIBITOR
4wnp:D (LEU119) to (GLN173) STRUCTURE OF ULK1 BOUND TO A POTENT INHIBITOR | KINASE, AUTOPHAGY, INHIBITOR
4h58:A (GLU548) to (LYS600) BRAF IN COMPLEX WITH COMPOUND 3 | PROTEIN KINASE, STRUCTURE BASED DRUG DISCOVERY, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2ow3:B (VAL155) to (GLN206) GLYCOGEN SYNTHASE KINASE-3 BETA IN COMPLEX WITH BIS- (INDOLE)MALEIMIDE PYRIDINOPHANE INHIBITOR | KINASE-INHIBITOR COMPLEX, TRANSFERASE
1atp:E (SER139) to (ARG190) 2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR | TRANSFERASE(PHOSPHOTRANSFERASE)
4wrs:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH AN AZASPIRO PYRAZINYL-INDAZOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE
1nvq:A (GLU104) to (ARG156) THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/UCN-01 | CHK1-UCN-01 COMPLEX, TRANSFERASE
1nvr:A (GLU104) to (ARG156) THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/STAUROSPORINE | CHK1-STAUROSPORINE COMPLEX, TRANSFERASE
1nvs:A (GLU104) to (ARG156) THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/SB218078 | CHK1-SB218078 COMPLEX, TRANSFERASE
4wsy:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A THIAZOLAMINE-INDAZOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2bil:B (GLN140) to (LEU192) THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE | PIM1, KINASE, CANCER, LEUKEMIA, TRANSFERASE
3f2a:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 IN COMPLEX WITH DAPPA | POTEIN KINASE FOLD, ALTERNATIVE INITIATION, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, KINASE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3f3z:A (LYS130) to (PHE176) CRYSTAL STRUCTURE OF CRYPTOSPORIDIUM PARVUM CALCIUM DEPENDENT PROTEIN KINASE CGD7_1840 IN PRESENCE OF INDIRUBIN E804 | CALCIUM DEPENDENT PROTEIN KINASE, STRUCTURAL GENOMICS CONSORTIUM, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SGC
2br1:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | TRANSFERASE, DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, X-RAY CRYSTALLOGRAPHY, KINASE
3f6x:A (LEU360) to (ILE411) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3f6x:B (GLN362) to (ILE411) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3f6x:C (PRO361) to (ILE411) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
2brb:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, TRANSFERASE
2brg:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, ATP-BINDING, CELL CYCLE, DNA DAMAGE, KINASE, NUCLEAR PROTEIN, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2brh:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, ATP-BINDING, CELL CYCLE, DNA DAMAGE, KINASE, NUCLEAR PROTEIN, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2brm:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, ATP-BINDING, CELL CYCLE, DNA DAMAGE, KINASE, NUCLEAR PROTEIN, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2brn:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, ATP-BINDING, CELL CYCLE, DNA DAMAGE, KINASE, NUCLEAR PROTEIN, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3f88:B (MET162) to (GLN206) GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR COMPLEX | ENZYME, PROTEIN KINASE, INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
3f9n:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHK1 KINASE IN COMPLEX WITH INHIBITOR 38 | CHEK1, CHK1, KINASE, CELL CYCLE CHECKPOINT, ATP-BINDING, CYTOPLASM, DNA DAMAGE, DNA REPAIR, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE, UBL CONJUGATION
3say:A (VAL155) to (GLN206) CRYSTAL STRUCTURE OF HUMAN GLYCOGEN SYNTHASE KINASE 3 BETA (GSK3B) IN COMPLEX WITH INHIBITOR 142 | KINASE, ATP HYDROLYSIS, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3fbv:A (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:B (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:C (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:D (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:E (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:F (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:G (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:H (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:I (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:J (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:K (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:L (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:M (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:N (PRO774) to (SER837) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3sdj:A (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:B (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:C (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:D (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:E (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:F (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:G (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:H (ILE775) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:I (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:J (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:K (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:L (ILE775) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:M (ILE775) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:N (PRO774) to (SER837) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
4hyh:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 39 BOUND TO HUMAN CHK1 KINASE DOMAIN | SERINE/THREONINE-PROTEIN KINASE CHK1 INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4hyi:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 40 BOUND TO HUMAN CHK1 KINASE DOMAIN | SERINE/THREONINE-PROTEIN KINASE CHK1 INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2pml:X (PRO144) to (TYR196) CRYSTAL STRUCTURE OF PFPK7 IN COMPLEX WITH AN ATP ANALOGUE | SER/THR PROTEIN KINASE; PLASMODIUM FALCIPARUM; PHOSPHORYLATION; TRANSFERASE, TRANSFERASE
2bzh:B (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1 | PIM1, KINASE, CANCER, LEUKEMIA, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE
2bzi:B (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2 | PIM1, KINASE, CANCER, LEUKEMIA, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE
2bzj:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU3 | PIM1, KINASE, CANCER, LEUKEMIA, NUCLEAR PROTEIN, NUCLEOTIDE- BINDING, TRANSFERASE
2bzk:B (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE | TRANSFERASE-PEPTIDE COMPLEX, COMPLEX TRANSFERASE/PEPTIDE, PIM1, KINASE, CANCER, LEUKEMIA, ATP-BINDING, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4xh6:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PROTO-ONCOGENE KINASE PIM1 BOUND TO HISPIDULIN | PIM1, HISPIDULIN, INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xhk:B (GLN140) to (LEU192) PIM1 KINASE IN COMPLEX WITH COMPOUND 1S | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3she:A (GLY151) to (GLU193) NOVEL ATP-COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICAL AND CELL- BASED ACTIVITY THROUGHOUT THE SERIES | KINASE DOMAIN WITH BOUND INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2c3i:B (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I | TRANSFERASE-PEPTIDE COMPLEX, COMPLEX TRANSFERASE/PEPTIDE, PIM1, KINASE, CANCER, LEUKEMIA, ATP-BINDING, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2c3j:A (GLU104) to (ARG156) IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION | DRUG DESIGN, MOLECULAR MODELING, MOLECULAR RECOGNITION, ONCOLOGY, TRANSFERASE, CELL CYCLE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, KINASE, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, UBL CONJUGATION
2c3k:A (GLU104) to (ARG156) IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION | DRUG DESIGN, MOLECULAR MODELING, MOLECULAR RECOGNITION, ONCOLOGY, ATP-BINDING, CELL CYCLE, DNA DAMAGE, DNA REPAIR, KINASE, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, UBL CONJUGATION
4i41:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE | SER/THR KINASE, MITOXANTRONE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2q0n:A (GLU414) to (SER466) STRUCTURE OF HUMAN P21 ACTIVATING KINASE 4 (PAK4) IN COMPLEX WITH A CONSENSUS PEPTIDE | PROTEIN KINASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, PAK4, STE20, KINASE, TRANSFERASE, ATP-BINDING, SERINE/THREONINE-PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
4iaa:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH THIORIDAZINE | PIM1 KINASE/ONCOGENE/THIORIDAZINE, SER/THR KINASE, THIORIDAZINE, TRANSFERASE
3fwq:A (THR129) to (PHE181) INACTIVE CONFORMATION OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT | CASEIN KINASE 2, PROTEIN KINASE CK2, EUKARYOTIC PROTEIN KINASES, INACTIVE CONFORMATION, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
3fwq:B (THR129) to (PHE181) INACTIVE CONFORMATION OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT | CASEIN KINASE 2, PROTEIN KINASE CK2, EUKARYOTIC PROTEIN KINASES, INACTIVE CONFORMATION, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
3fxz:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH RUTHENIUM COMPLEX LAMBDA-FL172 | TRANSFERASE, KINASE, ATP-BINDING, PHOSPHORYLATION, ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, APOPTOSIS, CELL JUNCTION, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE
3fy0:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH RUTHENIUM COMPLEX DW1 | TRANSFERASE, KINASE, ATP-BINDING, PHOSPHORYLATION, ALLOSTERIC ENZYME, APOPTOSIS, CELL JUNCTION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE
2cgw:A (GLU104) to (ARG156) IDENTIFICATION OF CHEMICALLY DIVERSE CHK1 INHIBITORS BY RECEPTOR-BASED VIRTUAL SCREENING | TRANSFERASE, DOCKING, DRUG DESIGN, ONCOLOGY, VIRTUAL SCREENING, ATP- BINDING, CELL CYCLE, DNA DAMAGE, DNA REPAIR, KINASE, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, UBL CONJUGATION
2cjm:A (LEU101) to (ALA151) MECHANISM OF CDK INHIBITION BY ACTIVE SITE PHOSPHORYLATION: CDK2 Y15P T160P IN COMPLEX WITH CYCLIN A STRUCTURE | PHOSPHORYLATION, NUCLEOTIDE-BINDING, MITOSIS, CELL CYCLE, REGULATION, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, TRANSFERASE, CELL DIVISION, CYCLIN-DEPENDENT KINASE, COMPLEX (TRANSFERASE/CELL DIVISION)
2qg5:A (GLU122) to (LYS177) CRYPTOSPORIDIUM PARVUM CALCIUM DEPENDENT PROTEIN KINASE CGD7_1840 | MALARIA, CALCIUM DEPENDENT KINASE, SGC, STRUCTURAL GENOMICS CONSORTIUM, TRANSFERASE
2qg5:D (ARG121) to (ARG175) CRYPTOSPORIDIUM PARVUM CALCIUM DEPENDENT PROTEIN KINASE CGD7_1840 | MALARIA, CALCIUM DEPENDENT KINASE, SGC, STRUCTURAL GENOMICS CONSORTIUM, TRANSFERASE
2qhm:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 2A | CHEK1, KINASE, CELL CYCLE CHECKPOINT, TRANSFERASE
2qhn:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 1A | CHEK1, KINASE, CELL CYCLE CHECKPOINT, TRANSFERASE
2cn8:A (GLU321) to (LEU375) CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH DEBROMOHYMENIALDISINE | ATP-BINDING, TRANSFERASE, KINASE DOMAIN, PHOSPHORYLATION, TUMOUR SUPPRESSOR, ACTIVATION SEGMENT, LI-FRAUMENI SYNDROME, SERINE/THREONINE-PROTEIN KINASE, CHK2, CDS1, RAD53, CHEK2, KINASE, CANCER, CHECKPOINT, NUCLEOTIDE-BINDING, HYPOTHETICAL PROTEIN
2qkw:B (SER137) to (THR190) STRUCTURAL BASIS FOR ACTIVATION OF PLANT IMMUNITY BY BACTERIAL EFFECTOR PROTEIN AVRPTO | THREE-HELIX BUNDLE MOTIF, AVRPTO-PTO DUPLEX, LAYERED BETA- SHEETS, KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4iq6:A (VAL155) to (GLN206) GSK-3BETA WITH INHIBITOR 6-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3- B]PYRIDIN-3-YL)PYRIDIN-2-AMINE | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4iq6:B (VAL155) to (GLN206) GSK-3BETA WITH INHIBITOR 6-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3- B]PYRIDIN-3-YL)PYRIDIN-2-AMINE | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3geq:B (PRO361) to (ILE411) STRUCTURAL BASIS FOR THE CHEMICAL RESCUE OF SRC KINASE ACTIVITY | KINASE, CHEMICAL RESCUE, PP2, ALTERNATIVE SPLICING, ATP- BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3t8o:A (GLU288) to (ALA341) RHODOPSIN KINASE (GRK1) L166K MUTANT AT 2.5A RESOLUTION | KINASE DOMAIN, RGS HOMOLOGY (RH) DOMAIN, G-PROTEIN RECEPTOR KINASE (GPCR), TRANSFERASE
4j1r:A (VAL155) to (GLN206) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH INHIBITOR 15R | STRUCTURAL GENOMICS, PSI-BIOLOGY, NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM, NYSGRC, KINASE, PHOSPHORYLATION, TRANSFERASE
4j1r:B (VAL155) to (GLN206) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH INHIBITOR 15R | STRUCTURAL GENOMICS, PSI-BIOLOGY, NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM, NYSGRC, KINASE, PHOSPHORYLATION, TRANSFERASE
4j1r:C (VAL155) to (GLN206) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH INHIBITOR 15R | STRUCTURAL GENOMICS, PSI-BIOLOGY, NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM, NYSGRC, KINASE, PHOSPHORYLATION, TRANSFERASE
4j1r:D (VAL155) to (GLN206) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH INHIBITOR 15R | STRUCTURAL GENOMICS, PSI-BIOLOGY, NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM, NYSGRC, KINASE, PHOSPHORYLATION, TRANSFERASE
2r0u:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 54 | CHEK1, KINASE, CELL CYCLE CHECK POINT, ATP-BINDING, CYTOPLASM, DNA DAMAGE, DNA REPAIR, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE, UBL CONJUGATION
1pyx:B (VAL155) to (GLN206) GSK-3 BETA COMPLEXED WITH AMP-PNP | KINASE, INSULIN PATHWAY, TRANSFERASE
4j71:B (MET162) to (GLN206) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH INHIBITOR 1R | STRUCTURAL GENOMICS, PSI-BIOLOGY, NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM, NYSGRC, KINASE, PHOSPHORYLATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4j7b:A (ARG144) to (ILE187) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 | FIRST COMPLEX STRUCTURE OF KD AND PBD DOMAIN, REGULATOR OF MITOSIS, PHOSPHORYLATED TARGET PROTEIN, TRANSFERASE
4j7b:D (ARG144) to (LYS186) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 | FIRST COMPLEX STRUCTURE OF KD AND PBD DOMAIN, REGULATOR OF MITOSIS, PHOSPHORYLATED TARGET PROTEIN, TRANSFERASE
4j8n:B (ASP229) to (HIS280) AURORA A KINASE APO | AURORA A, KINASE DOMAIN, TRANSFERASE
4j8n:D (ASP229) to (HIS280) AURORA A KINASE APO | AURORA A, KINASE DOMAIN, TRANSFERASE
4j97:B (THR599) to (ASN652) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC GAIN-OF-FUNCTION K659E MUTATION IDENTIFIED IN ENDOMETRIAL CANCER. | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, RECEPTOR TYROSINE KINASE, ATP BINDING, TRANSFERASE
3thb:A (THR149) to (TYR203) STRUCTURE OF PLK1 KINASE DOMAIN IN COMPLEX WITH A BENZOLACTAM-DERIVED INHIBITOR | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1q3d:B (VAL155) to (GLN206) GSK-3 BETA COMPLEXED WITH STAUROSPORINE | KINASE, INSULIN PATHWAY, TRANSFERASE
4y83:C (GLU227) to (GLN276) CRYSTAL STRUCTURE OF COT KINASE DOMAIN IN COMPLEX WITH 5-(2-AMINO-5- (QUINOLIN-3-YL)PYRIDIN-3-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE | COT, TPL-2, MAP3K8, KINASE, INHIBITOR, COMPLEX, TRANSFERASE
3tki:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHK1 IN COMPLEX WITH INHIBITOR S25 | CHK1, KINASE, CELL CHECKPOINT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tl8:A (ASP386) to (ASP442) THE AVRPTOB-BAK1 COMPLEX REVEALS TWO STRUCTURALLY SIMILAR KINASEINTERACTING DOMAINS IN A SINGLE TYPE III EFFECTOR | PLANT IMMUNITY, PSEUDOMONAS SYRINGAE, SOLANUM LYCOPERSICUM, PAMP- TRIGGERED IMMUNITY, BACTERIAL PATHOGENESIS, TRANSFERASE-LIGASE COMPLEX
3tl8:G (TRP387) to (ASP442) THE AVRPTOB-BAK1 COMPLEX REVEALS TWO STRUCTURALLY SIMILAR KINASEINTERACTING DOMAINS IN A SINGLE TYPE III EFFECTOR | PLANT IMMUNITY, PSEUDOMONAS SYRINGAE, SOLANUM LYCOPERSICUM, PAMP- TRIGGERED IMMUNITY, BACTERIAL PATHOGENESIS, TRANSFERASE-LIGASE COMPLEX
3tl8:H (TRP387) to (ASP442) THE AVRPTOB-BAK1 COMPLEX REVEALS TWO STRUCTURALLY SIMILAR KINASEINTERACTING DOMAINS IN A SINGLE TYPE III EFFECTOR | PLANT IMMUNITY, PSEUDOMONAS SYRINGAE, SOLANUM LYCOPERSICUM, PAMP- TRIGGERED IMMUNITY, BACTERIAL PATHOGENESIS, TRANSFERASE-LIGASE COMPLEX
4jik:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 22A (R)-2-(4-CHLOROPHENYL)-8- (PIPERIDIN-3-YLAMINO)IMIDAZO[1,2-C]PYRIMIDINE-5-CARBOXAMIDE BOUND TO HUMAN CHK1 KINASE DOMAIN | KINASE PHOSPHATASE TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yff:A (LEU560) to (PHE612) TNNI3K COMPLEXED WITH INHIBITOR 2 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yff:D (GLN561) to (PHE612) TNNI3K COMPLEXED WITH INHIBITOR 2 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yfi:A (LEU560) to (PHE612) TNNI3K COMPLEXED WITH INHIBITOR 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yfi:B (LEU560) to (PHE612) TNNI3K COMPLEXED WITH INHIBITOR 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yfi:C (LEU560) to (PHE612) TNNI3K COMPLEXED WITH INHIBITOR 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yfi:D (LEU560) to (PHE612) TNNI3K COMPLEXED WITH INHIBITOR 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2rio:A (PRO117) to (SER180) STRUCTURE OF THE DUAL ENZYME IRE1 REVEALS THE BASIS FOR CATALYSIS AND REGULATION OF NON-CONVENTIONAL SPLICING | PROTEIN-NUCLEOTIDE COMPLEX, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, KINASE, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE- BINDING, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
2rio:B (PRO117) to (SER180) STRUCTURE OF THE DUAL ENZYME IRE1 REVEALS THE BASIS FOR CATALYSIS AND REGULATION OF NON-CONVENTIONAL SPLICING | PROTEIN-NUCLEOTIDE COMPLEX, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, KINASE, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE- BINDING, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3h30:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF HUMAN PROTEIN KINASE CK2 WITH 5,6-DICHLORO-1-BETA-D- RIBOFURANOSYLBENZIMIDAZOLE | PROTEIN KINASE CK2, CASEIN KINASE 2, CASEIN KINASE II, ATP- BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
1qpe:A (ILE338) to (ASP391) STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS | ALPHA BETA FOLD, TRANSFERASE
1qpj:A (ILE338) to (GLU390) CRYSTAL STRUCTURE OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH STAUROSPORINE. | ALPHA BETA FOLD, TRANSFERASE
4yhj:A (ASP285) to (PRO338) STRUCTURE AND FUNCTION OF THE HYPERTENSION VARIANT A486V OF G PROTEIN- COUPLED RECEPTOR KINASE 4 (GRK4) | TRANSFERASE
4yht:A (GLU548) to (VAL599) BRAF COMPLEXED WITH AN INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yht:B (GLU548) to (VAL599) BRAF COMPLEXED WITH AN INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4jrn:A (PHE381) to (ASN434) ROP18 KINASE DOMAIN IN COMPLEX WITH AMP-PNP AND SUCROSE | PROTEIN KINASE, KINASE, MEMBRANE, TRANSFERASE
2e9n:A (GLU104) to (ARG156) STRUCTURE OF H-CHK1 COMPLEXED WITH A767085 | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
2e9o:A (GLU104) to (ARG156) STRUCTURE OF H-CHK1 COMPLEXED WITH AA582939 | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
2e9u:A (GLU104) to (ARG156) STRUCTURE OF H-CHK1 COMPLEXED WITH A780125 | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
4jx7:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR 2-[(TRANS- 4-AMINOCYCLOHEXYL)AMINO]-4-{[3-(TRIFLUOROMETHYL) PHENYL]AMINO}PYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE | SERINE/THREONINE-PROTEIN KINASES, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3u9n:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 1 BOUND TO HUMAN CHK1 KINASE DOMAIN | PROTEIN KINASE DOMAIN, ATPASE, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3hgk:A (SER137) to (THR190) CRYSTAL STRUCTURE OF EFFECT PROTEIN AVRPTOB COMPLEXED WITH KINASE PTO | FIVE HELICES, PTO P+1 LOOP, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, HYPERSENSITIVE RESPONSE ELICITATION, LIGASE, SECRETED, UBL CONJUGATION, UBL CONJUGATION PATHWAY, VIRULENCE, TRANSFERASE
3hgk:B (GLU139) to (THR190) CRYSTAL STRUCTURE OF EFFECT PROTEIN AVRPTOB COMPLEXED WITH KINASE PTO | FIVE HELICES, PTO P+1 LOOP, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, HYPERSENSITIVE RESPONSE ELICITATION, LIGASE, SECRETED, UBL CONJUGATION, UBL CONJUGATION PATHWAY, VIRULENCE, TRANSFERASE
3hgk:C (SER137) to (THR190) CRYSTAL STRUCTURE OF EFFECT PROTEIN AVRPTOB COMPLEXED WITH KINASE PTO | FIVE HELICES, PTO P+1 LOOP, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, HYPERSENSITIVE RESPONSE ELICITATION, LIGASE, SECRETED, UBL CONJUGATION, UBL CONJUGATION PATHWAY, VIRULENCE, TRANSFERASE
3hgk:D (SER137) to (GLY189) CRYSTAL STRUCTURE OF EFFECT PROTEIN AVRPTOB COMPLEXED WITH KINASE PTO | FIVE HELICES, PTO P+1 LOOP, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, HYPERSENSITIVE RESPONSE ELICITATION, LIGASE, SECRETED, UBL CONJUGATION, UBL CONJUGATION PATHWAY, VIRULENCE, TRANSFERASE
4k0y:A (GLN140) to (LEU192) STRUCTURE OF PIM-1 KINASE BOUND TO N-(4-FLUOROPHENYL)-7-HYDROXY-5- (PIPERIDIN-4-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | PIM-1, KINASE, SER/THR KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4k18:A (GLN140) to (LEU192) STRUCTURE OF PIM-1 KINASE BOUND TO 5-(4-CYANOBENZYL)-N-(4- FLUOROPHENYL)-7-HYDROXYPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | PIM-1, KINASE DOMAIN, SER/THR KINASE, ATP-COMPETITIVE, STRUCTURE- BASED DRUG DESIGN, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4k1b:A (GLN140) to (LEU192) STRUCTURE OF PIM-1 KINASE BOUND TO N-(5-(2-FLUOROPHENYL)-1H-PYRROLO[2, 3-B]PYRIDIN-3-YL)-5-((((3R,4R)-3-FLUOROPIPERIDIN-4-YL)METHYL)AMINO) PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | PIM-1, KINASE DOMAIN, SER/THR KINASE, ATP-COMPETITIVE, STRUCTURE- BASED DRUG DESIGN, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3hko:A (ASP144) to (GLU201) CRYSTAL STRUCTURE OF A CDPK KINASE DOMAIN FROM CRYPTOSPORIDIUM PARVUM, CGD7_40 | STRUCTURAL GENOMICS, PROTIST PARASITE, CRYPTOSPORIDIUM PARVUM, CDPK, ZINC FINGER, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3uix:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL MOLECULE INHIBITOR | PIM-1, LEUKEMIA CELL LETHALITY, SUBSTRATE-PEPTIDE-BINDING RESIDUE, FLUORESCENT CORRELATION SPECTROSCOPY, INHIBITOR COMPLEX, IN SILICO SCREENING, TRANSFERASE-INHIBITOR COMPLEX
2f4j:A (ASN336) to (MET388) STRUCTURE OF THE KINASE DOMAIN OF AN IMATINIB-RESISTANT ABL MUTANT IN COMPLEX WITH THE AURORA KINASE INHIBITOR VX-680 | KINASE, KINASE INHIBITOR, ABL, TRANSFERASE
3ulz:A (TRP387) to (ASP442) CRYSTAL STRUCTURE OF APO BAK1 | KINASE, TRANSFERASE
2f57:B (ASN541) to (SER594) CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 5 | PAK5, KINASE DOMAINS, GROUPII PAKS, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3umw:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR (Z)-2-[(1H- INDAZOL-3-YL)METHYLENE]-6-METHOXY-7-(PIPERAZIN-1-YLMETHYL)BENZOFURAN- 3(2H)-ONE | PIM1, KINASE INHIBITOR, RATIONAL DRUG DESIGN, LEUKEMIA, TRANSFERASE- INHIBITOR COMPLEX
3umx:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR (Z)-2-[(1H- INDOL-3-YL)METHYLENE]-7-(AZEPAN-1-YLMETHYL)-6-HYDROXYBENZOFURAN- 3(2H)-ONE | PIM-1, KINASE, P-LOOP, KINASE INHIBITOR, RATIONAL DRUG DESIGN, TRANSFERASE-INHIBITOR COMPLEX
4yzn:A (TRP1126) to (SER1184) HUMANIZED ROCO4 BOUND TO COMPOUND 19 | ROCO-PROTEIN, KINASE, LRRK2, INHIBITOR, ROCO4, TRANSFERASE
2f7x:E (ALA147) to (VAL191) PROTEIN KINASE A BOUND TO (S)-2-(1H-INDOL-3-YL)-1-[5-((E)-2- PYRIDIN-4-YL-VINYL)-PYRIDIN-3-YLOXYMETHYL]-ETHYLAMINE | PROTEIN KINASE A, AKT INHIBITORS, TRANSFERASE
3uqg:A (PRO361) to (ILE411) C-SRC KINASE DOMAIN IN COMPLEX WITH BUMPLESS BKI ANALOG UW1243 | TYROSINE PROTEIN KINASE, ATP-BINDING, KINASE DOMAIN, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3uqg:B (PRO361) to (ILE411) C-SRC KINASE DOMAIN IN COMPLEX WITH BUMPLESS BKI ANALOG UW1243 | TYROSINE PROTEIN KINASE, ATP-BINDING, KINASE DOMAIN, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4z7h:A (GLU664) to (VAL720) CRYSTAL STRUCTURE OF HUMAN IRE1 CYTOPLASMIC KINASE-RNASE REGION - COMPLEX WITH IMIDAZOPYRIDINE COMPOUND 3 | TRANSFERASE, KINASE, RNASE, UNFOLDED PROTEIN RESPONSE
4z7h:B (GLU664) to (ALA719) CRYSTAL STRUCTURE OF HUMAN IRE1 CYTOPLASMIC KINASE-RNASE REGION - COMPLEX WITH IMIDAZOPYRIDINE COMPOUND 3 | TRANSFERASE, KINASE, RNASE, UNFOLDED PROTEIN RESPONSE
3v5w:A (SER290) to (SER343) HUMAN G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH SOLUBLE GBETAGAMMA SUBUNITS AND PAROXETINE | INHIBITOR COMPLEX, PROTEIN KINASE, BETA PROPELLER, RGS HOMOLOGY DOMAIN, PLECKSTRIN HOMOLOGY DOMAIN, KINASE, SIGNAL TRANSDUCTION, PERIPHERAL MEMBRANE PROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1gng:B (MET162) to (GLN206) GLYCOGEN SYNTHASE KINASE-3 BETA (GSK3) COMPLEX WITH FRATTIDE PEPTIDE | TRANSFERASE, PROTEIN KINASE, GSK3/FRATTIDE COMPLEX, PHOSPHORYLATED, ACTIVE
2g2h:A (ASN355) to (ARG405) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
2g2h:B (ASN355) to (MET407) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
3vbq:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, ROSSMANN FOLD, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbt:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbv:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbw:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbx:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vby:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vc4:A (GLN140) to (LEU192) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3i6w:B (LYS320) to (LEU375) STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA-DAMAGE CHECKPOINT KINASE | SER/THR PROTEIN KINASE, FHA DOMAIN, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, KINASE, LI-FRAUMENI SYNDROME, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3i6w:D (LYS320) to (LEU375) STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA-DAMAGE CHECKPOINT KINASE | SER/THR PROTEIN KINASE, FHA DOMAIN, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, KINASE, LI-FRAUMENI SYNDROME, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3i6w:F (LYS320) to (LEU375) STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA-DAMAGE CHECKPOINT KINASE | SER/THR PROTEIN KINASE, FHA DOMAIN, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, KINASE, LI-FRAUMENI SYNDROME, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3i6w:H (LYS320) to (LEU375) STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA-DAMAGE CHECKPOINT KINASE | SER/THR PROTEIN KINASE, FHA DOMAIN, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, KINASE, LI-FRAUMENI SYNDROME, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2gdo:A (PRO103) to (ARG156) 4-(AMINOALKYLAMINO)-3-BENZIMIDAZOLE-QUINOLINONES AS POTENT CHK1 INHIBITORS | DRUG DESIGN, ATP-BINDING, CELL CYCLE, DNA DAMAGE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4l67:A (GLU415) to (SER466) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF PAK4 | CATALYTIC DOMAIN OF PAK4, TRANSFERASE
2w04:A (ASP412) to (THR471) CO-COMPLEX STRUCTURE OF ACHROMOBACTIN SYNTHETASE PROTEIN D ( ACSD) WITH CITRATE IN ATP BINDING SITE FROM PECTOBACTERIUM CHRYSANTHEMI | ACSD, PECTOBACTERIUM CHRYSANTHEMI, ACHROMOBACTIN BIOSYNTHESIS, SSPF, METAL TRANSPORT
2w04:B (ASP411) to (THR471) CO-COMPLEX STRUCTURE OF ACHROMOBACTIN SYNTHETASE PROTEIN D ( ACSD) WITH CITRATE IN ATP BINDING SITE FROM PECTOBACTERIUM CHRYSANTHEMI | ACSD, PECTOBACTERIUM CHRYSANTHEMI, ACHROMOBACTIN BIOSYNTHESIS, SSPF, METAL TRANSPORT
2w0j:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR | CHK2 INHIBITOR, ONCOLOGY, KINASE, STRUCTURE-ASSISTED DRUG DESIGN, TRANSFERASE, NUCLEOTIDE-BINDING, LI-FRAUMENI SYNDROME, SERINE/THREONINE-PROTEIN KINASE
4zog:A (ASN336) to (MET388) VX-680/MK-0457 BINDS TO HUMAN ABL1 ALSO IN INACTIVE DFG CONFORMATIONS. | KINASE, TRANSFERASE, ABL1, DFG CONFORMATIONS
4zog:B (ASN336) to (THR389) VX-680/MK-0457 BINDS TO HUMAN ABL1 ALSO IN INACTIVE DFG CONFORMATIONS. | KINASE, TRANSFERASE, ABL1, DFG CONFORMATIONS
4l9i:A (GLU288) to (ALA341) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH PAROXETINE | AGC FAMILY KINASE, SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, SSRI, HYDROLYASE, GPCR, PHOSPHORYLATION, TRANSFERASE, MEMBRANE PROTEIN- INHIBITOR COMPLEX
4l9i:B (GLU288) to (LEU339) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH PAROXETINE | AGC FAMILY KINASE, SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, SSRI, HYDROLYASE, GPCR, PHOSPHORYLATION, TRANSFERASE, MEMBRANE PROTEIN- INHIBITOR COMPLEX
1tqm:A (PRO195) to (VAL242) CRYSTAL STRUCTURE OF A. FULGIDUS RIO2 SERINE PROTEIN KINASE BOUND TO AMPPNP | SERINE KINASE, AMPPNP, ANP, RIBOSOME
4zy4:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF P21 ACTIVATED KINASE 1 IN COMPLEX WITH AN INHIBITOR COMPOUND 4 | KINASE, INHIBITOR, COMPLEX
4zy5:A (GLY364) to (THR415) CRYSTAL STRUCTURE OF P21-ACTIVATED KINASE 1 IN COMPLEX WITH AN INHIBITOR COMPOUND 17 | KINASE, INHIBITOR, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ll5:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM-1 IN COMPLEX WITH THE FLUORESCENT COMPOUND SKF86002 | CO-CRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lmu:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH THE INHIBITOR QUERCETIN (RESULTING FROM DISPLACEMENT OF SKF86002) | CO-CRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1i09:B (VAL155) to (LEU207) STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B) | KINASE, BETA BARREL, TRANSFERASE
2wmq:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
2wmr:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
2wms:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
2wmt:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
2wmu:A (PRO103) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
2wmw:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
4lrm:A (GLY813) to (GLY866) EGFR D770_N771INSNPG IN COMPLEX WITH PD168393 | EGFR, KINASE, PD168393, 34-JAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lrm:D (SER814) to (GLY866) EGFR D770_N771INSNPG IN COMPLEX WITH PD168393 | EGFR, KINASE, PD168393, 34-JAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1i2s:B (GLY217) to (PRO254) BETA-LACTAMASE FROM BACILLUS LICHENIFORMIS BS3 | SERINE BETA-LACTAMASE, HYDROLASE, ANTIBIOTIC RESISTANCE
1u59:A (VAL435) to (GLY487) CRYSTAL STRUCTURE OF THE ZAP-70 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE | TRANSFERASE
2hxq:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 2 | CHEK1, KINASE, CELL CYCLE CHECKPOINT, TRANSFERASE
2hzi:B (ASN336) to (LEU387) ABL KINASE DOMAIN IN COMPLEX WITH PD180970 | TYROSINE KINASE, TRANSFERASE
1ia8:A (GLU104) to (ARG156) THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1 | PROTEIN KINASE, TRANSFERASE
2wtc:A (GLU321) to (LEU375) CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, KINASE, CELL CYCLE, LI-FRAUMENI SYNDROME
2wtd:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, KINASE, CELL CYCLE, LI-FRAUMENI SYNDROME
2wtk:B (GLU169) to (ILE221) STRUCTURE OF THE HETEROTRIMERIC LKB1-STRADALPHA-MO25ALPHA COMPLEX | TRANSFERASE-METAL-BINDING PROTEIN COMPLEX, TRANSFERASE METAL-BINDING PROTEIN COMPLEX, KINASE, NUCLEUS, SERINE/THREONINE-PROTEIN KINASE, PSEUDOKINASE, PHOSPHOPROTEIN, SIGNAL TRANSDUCTION, TRANSFERASE, NUCLEOTIDE-BINDING
2wtk:C (CYS151) to (HIS202) STRUCTURE OF THE HETEROTRIMERIC LKB1-STRADALPHA-MO25ALPHA COMPLEX | TRANSFERASE-METAL-BINDING PROTEIN COMPLEX, TRANSFERASE METAL-BINDING PROTEIN COMPLEX, KINASE, NUCLEUS, SERINE/THREONINE-PROTEIN KINASE, PSEUDOKINASE, PHOSPHOPROTEIN, SIGNAL TRANSDUCTION, TRANSFERASE, NUCLEOTIDE-BINDING
2wtk:F (PRO149) to (HIS202) STRUCTURE OF THE HETEROTRIMERIC LKB1-STRADALPHA-MO25ALPHA COMPLEX | TRANSFERASE-METAL-BINDING PROTEIN COMPLEX, TRANSFERASE METAL-BINDING PROTEIN COMPLEX, KINASE, NUCLEUS, SERINE/THREONINE-PROTEIN KINASE, PSEUDOKINASE, PHOSPHOPROTEIN, SIGNAL TRANSDUCTION, TRANSFERASE, NUCLEOTIDE-BINDING
2i6l:A (LEU125) to (ILE177) CRYSTAL STRUCTURE OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE 6 (MAPK6) | MAPK6, ERK3, MITOGEN ACTIVATED PROTEIN KINASE 6, EXTRACELLULAR SIGNAL REGULATED KINASE 3, SERINE PHOSPHORYLATION, THREONINE PHOSPHORYLATION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4mbi:A (GLU141) to (LEU192) DISCOVERY OF PYRAZOLO[1,5A]PYRIMIDINE-BASED PIM1 INHIBITORS | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mbl:A (GLN140) to (LEU192) DISCOVERY OF PYRAZOLO[1,5A]PYRIMIDINE-BASED PIM1 INHIBITORS | KINASE, PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3we8:A (GLN140) to (LEU192) PIM-1 KINASE IN COMPLEX WITH RUTHENIUM-BASED INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4md8:G (THR129) to (PHE181) CRYSTAL STRUCTURE OF FULL-LENGTH SYMMETRIC CK2 HOLOENZYME WITH MUTATED ALPHA SUBUNIT (F121E) | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4md8:H (THR129) to (PHE181) CRYSTAL STRUCTURE OF FULL-LENGTH SYMMETRIC CK2 HOLOENZYME WITH MUTATED ALPHA SUBUNIT (F121E) | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
2x0q:A (LEU432) to (ASN478) CO-COMPLEX STRUCTURE OF ALCALIGIN BIOSYNTHESIS PROTEIN C (ALCC) WITH ATP FROM BORDETELLA BRONCHISEPTICA | ALCALIGIN BIOSYNTHESIS, ADENYLATION, SIDEROPHORES, IRON ACQUISITION, BIOSYNTHETIC PROTEIN
4med:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH THIORIDAZINE DERIVATIVES | PROTEIN-LIGAND COMPLEX, KINASE, ONCOGENE, ATP BINDING, PHOSPHORYLATION, NUCLEUS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1j1b:B (MET662) to (GLN706) BINARY COMPLEX STRUCTURE OF HUMAN TAU PROTEIN KINASE I WITH AMPPNP | COMPLEX, TAU, KINASE, AMPPNP, TRANSFERASE
1j1c:A (VAL155) to (GLN206) BINARY COMPLEX STRUCTURE OF HUMAN TAU PROTEIN KINASE I WITH ADP | COMPLEX, TAU, KINASE, ADP, TRANSFERASE
1j1c:B (VAL655) to (GLN706) BINARY COMPLEX STRUCTURE OF HUMAN TAU PROTEIN KINASE I WITH ADP | COMPLEX, TAU, KINASE, ADP, TRANSFERASE
3wi6:A (GLU160) to (THR215) CRYSTAL STRUCTURE OF MAPKAP KINASE-2 (MK2) IN COMPLEX WITH NON- SELECTIVE INHIBITOR | GLY-RICH LOOP FORMED, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3wi6:B (GLU160) to (THR215) CRYSTAL STRUCTURE OF MAPKAP KINASE-2 (MK2) IN COMPLEX WITH NON- SELECTIVE INHIBITOR | GLY-RICH LOOP FORMED, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3wi6:C (GLU160) to (THR215) CRYSTAL STRUCTURE OF MAPKAP KINASE-2 (MK2) IN COMPLEX WITH NON- SELECTIVE INHIBITOR | GLY-RICH LOOP FORMED, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3wi6:E (GLU160) to (THR215) CRYSTAL STRUCTURE OF MAPKAP KINASE-2 (MK2) IN COMPLEX WITH NON- SELECTIVE INHIBITOR | GLY-RICH LOOP FORMED, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3wi6:F (GLU160) to (THR215) CRYSTAL STRUCTURE OF MAPKAP KINASE-2 (MK2) IN COMPLEX WITH NON- SELECTIVE INHIBITOR | GLY-RICH LOOP FORMED, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2x8d:A (GLU104) to (ARG156) DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION | NUCLEOTIDE-BINDING, CYTOSKELETON, PHOSPHOPROTEIN, ISOPEPTIDE BOND, CELL CYCLE, TRANSFERASE, DNA DAMAGE, DNA REPAIR
2x8e:A (PRO103) to (ARG156) DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION | NUCLEOTIDE-BINDING, CYTOSKELETON, PHOSPHOPROTEIN, ISOPEPTIDE BOND, CELL CYCLE, TRANSFERASE, DNA DAMAGE, DNA REPAIR
2x8i:A (GLU104) to (ARG156) DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION | NUCLEOTIDE-BINDING, CYTOSKELETON, PHOSPHOPROTEIN, ISOPEPTIDE BOND, CELL CYCLE, TRANSFERASE, DNA DAMAGE, DNA REPAIR
2iwi:A (GLY136) to (LEU188) CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1 | NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, PIM2, KINASE, CANCER, LEUKEMIA, TRANSFERASE, ATP-BINDING, PROTO- ONCOGENE, PHOSPHORYLATION
4mne:F (MET550) to (LYS601) CRYSTAL STRUCTURE OF THE BRAF:MEK1 COMPLEX | RAF, MAPK, KINASE DOMAIN, ATP-BINDING, ERK, RAS, PAK, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4mnf:A (MET550) to (GLU600) CRYSTAL STRUCTURE OF BRAF-V600E BOUND TO GDC0879 | RAF, MAPK, KINASE DOMAIN, ATP-BINDING, ERK, RAS, PAK, ACTIVE CONFORMATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2xbj:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, DNA REPAIR, PARP
2j2i:B (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAB PIM1 IN COMPLEX WITH LY333531 | TRANSFERASE, NUCLEOTIDE-BINDING, ALTERNATIVE INITIATION, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, METAL-BINDING, PROTO-ONCOGENE, KINASE, CANCER, LEUKEMIA, MANGANESE, NUCLEAR PROTEIN, PROTO- ONCOGENE, PHOSPHORYLATION
5ar5:A (TRP118) to (ARG171) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BENZIMIDAZOLE | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
1jkk:A (LEU120) to (ASP169) 2.4A X-RAY STRUCTURE OF TERNARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE AND MG. | TRANSFERASE
5ar2:A (TRP118) to (ARG171) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar3:A (TRP118) to (MET172) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH AMP-PCP | TRANSFERASE, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar3:B (TRP118) to (MET172) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH AMP-PCP | TRANSFERASE, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
2xey:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, CELL CYCLE
2xez:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, CELL CYCLE
5auu:A (THR112) to (ASP169) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH LUTEOLIN. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
5av0:A (LEU120) to (ASP169) CRYSTAL STRUCTURE OF DAPK1 IN COMPLEX WITH 7,3',4'- TRIHYDROXYISOFLAVONE. | DEATH-ASSOCIATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE, NATURAL FLAVONOID
2xix:A (GLN140) to (LEU192) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-1 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | ATP-BINDING, PHOSPHORYLATION, TRANSFERASE
2xiy:A (GLN140) to (LEU192) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-2 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | PHOSPHORYLATION, TRANSFERASE
2xiz:A (GLN140) to (LEU192) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-3 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | PHOSPHORYLATION, TRANSFERASE
2xj1:A (GLN140) to (LEU192) PROTEIN KINASE PIM-1 IN COMPLEX WITH SMALL MOLECULE INIBITOR | PHOSPHORYLATION, TRANSFERASE
2xk9:A (LYS320) to (GLU377) STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 (CHK2) IN COMPLEX WITH INHIBITOR PV1533 | STRUCTURE-BASED DRUG DESIGN, TRANSFERASE
4mxz:B (PRO361) to (ILE411) SRC M314L T338M DOUBLE MUTANT BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1jsu:A (LEU101) to (ALA151) P27(KIP1)/CYCLIN A/CDK2 COMPLEX | COMPLEX (TRANSFERASE/CYCLIN/INHIBITOR), KINASE, CELL CYCLE, CELL DIVISION, CDK, CYCLIN, INHIBITOR
2xm8:A (LYS320) to (LEU375) CO-CRYSTAL STRUCTURE OF A SMALL MOLECULE INHIBITOR BOUND TO THE KINASE DOMAIN OF CHK2 | TRANSFERASE, CANCER
2xm9:A (LYS320) to (GLU377) STRUCTURE OF A SMALL MOLECULE INHIBITOR WITH THE KINASE DOMAIN OF CHK2 | TRANSFERASE, CANCER
2jdv:A (ALA147) to (VAL191) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH A-443654 | CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION
4n6z:A (GLN140) to (LEU192) PIM1 COMPLEXED WITH A PYRIDYLCARBOXAMIDE | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4n70:A (GLN140) to (LEU192) PIM1 COMPLEXED WITH A PYRIDYLCARBOXAMIDE | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2jgz:A (LEU101) to (ALA151) CRYSTAL STRUCTURE OF PHOSPHO-CDK2 IN COMPLEX WITH CYCLIN B | PROTEIN KINASE, UBL CONJUGATION, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, KINASE, CYCLIN, MITOSIS, CELL CYCLE, TRANSFERASE, ATP-BINDING, POLYMORPHISM, CELL DIVISION, NUCLEOTIDE-BINDING, SUBSTRATE SPECIFICITY
2y4p:D (GLU113) to (ILE168) DIMERIC STRUCTURE OF DAPK-1 CATALYTIC DOMAIN | CALMODULIN-BINDING, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, APOPTOSIS, TRANSFERASE, ATP-BINDING
3zmm:A (ASP949) to (GLN1003) INHIBITORS OF JAK2 KINASE DOMAIN | TRANSFERASE
4nm0:A (MET162) to (GLN206) CRYSTAL STRUCTURE OF PEPTIDE INHIBITOR-FREE GSK-3/AXIN COMPLEX | WNT, LRP6, AUTO-INHIBITED, GSK-3, AXIN, KINASE, PRIMED SUBSTRATE, TRANSFERASE-PEPTIDE COMPLEX
4nm5:A (MET162) to (GLN206) CRYSTAL STRUCTURE OF GSK-3/AXIN COMPLEX BOUND TO PHOSPHORYLATED WNT RECEPTOR LRP6 C-MOTIF | WNT, LRP6, AUTO-INHIBITED, GSK-3, AXIN, KINASE, PRIMED SUBSTRATE, PHOSPHORYLATED WNT RECEPTOR LRP6 C-MOTIF, TRANSFERASE-PEPTIDE COMPLEX
4nm7:A (MET162) to (GLN206) CRYSTAL STRUCTURE OF GSK-3/AXIN COMPLEX BOUND TO PHOSPHORYLATED WNT RECEPTOR LRP6 E-MOTIF | WNT, LRP6, AUTO-INHIBITED, GSK-3, PRIMED SUBSTRATE, KINASE, AXIN, PHOSPHORYLATED WNT RECEPTOR LRP6 E-MOTIF, TRANSFERASE-PEPTIDE COMPLEX
5c1q:B (GLU141) to (LEU192) SERINE/THREONINE-PROTEIN KINASE PIM-1 | PROTEIN-LIGAND COMPLEX, TRANSFERASE
2lav:A (SER150) to (CYS205) NMR SOLUTION STRUCTURE OF HUMAN VACCINIA-RELATED KINASE 1 | VRK1, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, MITOSIS, CELL CYCLE
2yac:A (GLU150) to (TYR203) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH NMS-P937 | TRANSFERASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, NUCLEUS
3zrk:A (VAL155) to (GLN206) IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
3zrk:B (MET162) to (GLN206) IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
3zrl:A (MET162) to (GLN206) IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
3zrl:B (MET162) to (GLN206) IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
3zrm:A (VAL155) to (GLN206) IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK- 3BETA INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
3zrm:B (MET162) to (GLN206) IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK- 3BETA INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
2ycf:A (LYS320) to (GLU377) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV1531 | TRANSFERASE, ANTICANCER, ANTICANCER DRUG DESIGN
2ycq:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV1115 | TRANSFERASE, ANTICANCER DRUG DESIGN
2ycr:A (LYS320) to (GLU377) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV976 | TRANSFERASE, ANTICANCER DRUG DESIGN
2ycs:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 2 IN COMPLEX WITH PV788 | TRANSFERASE, ANTICANCER DRUG DESIGN
2ydi:A (GLU104) to (ARG156) DISCOVERY OF CHECKPOINT KINASE INHIBITOR AZD7762 BY STRUCTURE BASED DESIGN AND OPTIMIZATION OF THIOPHENE CARBOXAMIDE UREAS | TRANSFERASE, CHK
2ydj:A (GLU104) to (ARG156) DISCOVERY OF CHECKPOINT KINASE INHIBITOR AZD7762 BY STRUCTURE BASED DESIGN AND OPTIMIZATION OF THIOPHENE CARBOXAMIDE UREAS | TRANSFERASE
2ydj:B (GLU104) to (ARG156) DISCOVERY OF CHECKPOINT KINASE INHIBITOR AZD7762 BY STRUCTURE BASED DESIGN AND OPTIMIZATION OF THIOPHENE CARBOXAMIDE UREAS | TRANSFERASE
2ydk:A (GLU104) to (ARG156) DISCOVERY OF CHECKPOINT KINASE INHIBITOR AZD7762 BY STRUCTURE BASED DESIGN AND OPTIMIZATION OF THIOPHENE CARBOXAMIDE UREAS | TRANSFERASE
4nts:A (ALA147) to (ARG190) APO STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE | PROTEIN KINASE FOLD, PHOSPHORYL TRANSFERASE, KINASE, REGULATORY SUBUNIT OF PKA, PKI, PHOSPHORYLATION, TRANSFERASE
4o0t:A (GLU363) to (THR415) BACK POCKET FLEXIBILITY PROVIDES GROUP-II PAK SELECTIVITY FOR TYPE 1 KINASE INHIBITORS | PAK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4o0x:A (GLU414) to (SER466) BACK POCKET FLEXIBILITY PROVIDES GROUP-II PAK SELECTIVITY FOR TYPE 1 KINASE INHIBITORS | PAK4, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2yiq:A (LYS320) to (GLU377) STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV1322 | TRANSFERASE
2yit:A (LYS320) to (GLY376) STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 IN COMPLEX WITH PV1162, A NOVEL INHIBITOR | TRANSFERASE, STRUCTURE-BASED DRUG DESIGN, CELL CYCLE
4o1o:A (GLU457) to (TRP507) CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH 2-5A | ANKYRIN REPEAT-KINASE-RNASE, 2-5A, TRANSFERASE, TRANSFERASE,HYDROLASE
4o1o:B (SER458) to (TRP507) CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH 2-5A | ANKYRIN REPEAT-KINASE-RNASE, 2-5A, TRANSFERASE, TRANSFERASE,HYDROLASE
4o1o:C (GLU457) to (TRP507) CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH 2-5A | ANKYRIN REPEAT-KINASE-RNASE, 2-5A, TRANSFERASE, TRANSFERASE,HYDROLASE
4o1o:D (GLU457) to (TRP507) CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH 2-5A | ANKYRIN REPEAT-KINASE-RNASE, 2-5A, TRANSFERASE, TRANSFERASE,HYDROLASE
2ym5:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR
2ym7:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, CELL CYCLE
2ym8:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, SERINE/THREONINE KINASE
3juh:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF A MUTANT OF HUMAN PROTEIN KINASE CK2ALPHA WITH ALTERED COSUBSTRATE SPECIFICITY | EUKARYOTIC PROTEIN KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
3jvs:A (GLU104) to (ARG156) CHARACTERIZATION OF THE CHK1 ALLOSTERIC INHIBITOR BINDING SITE | PROTEIN KINASE, ATP-BINDING, CELL CYCLE, CYTOPLASM, DNA DAMAGE, DNA REPAIR, ISOPEPTIDE BOND, KINASE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, UBL CONJUGATION
3jya:A (GLN140) to (LEU192) DISCOVERY OF 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONES AS POTENT, HIGHLY SELECTIVE AND ORALLY BIOAVAILABLE PIM KINASES INHIBITORS | PIM-1, ALTERNATIVE INITIATION, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, KINASE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2ywp:A (PRO103) to (ARG156) CRYSTAL STRUCTURE OF CHK1 WITH A UREA INHIBITOR | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
5clp:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH 3,4-DICHLOROPHENETHYLAMINE BOUND | TRANSFERASE, CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION
4oh4:B (SER981) to (SER1035) CRYSTAL STRUCTURE OF BRI1 IN COMPLEX WITH BKI1 | KINASE DOMAIN, TRANSFERASE, ATP BINDING, PHOSPHORYLATION, MEMBRANE, TRANSFERASE-SIGNALING PROTEIN COMPLEX
2z60:A (SER336) to (MET388) CRYSTAL STRUCTURE OF THE T315I MUTANT OF ABL KINASE BOUND WITH PPY-A | ABL, KINASE, MUTANT, T315I, ALTERNATIVE SPLICING, ATP- BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHORYLATION, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
2o3p:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 WITH QUERCETIN | PIM1, QUERCETIN, TRANSFERASE
5cqu:A (THR129) to (PHE181) MONOCLINIC COMPLEX STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH A BENZOTRIAZOLE-BASED INHIBITOR GENERATED BY CLICK-CHEMISTRY | TRANSFERASE, ATP-COMPETITIVE INHIBITOR, PROTEIN KINASE CK2, CASEIN KINASE 2
4a5r:A (LEU220) to (PRO254) CRYSTAL STRUCTURE OF CLASS A BETA-LACTAMASE FROM BACILLUS LICHENIFORMIS BS3 WITH TAZOBACTAM | HYDROLASE
5cs6:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH COMPOUND 3 BOUND | TRANSFERASE, CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION
5cs6:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH COMPOUND 3 BOUND | TRANSFERASE, CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION
5csh:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH COMPOUND 4 BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
2o63:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 WITH MYRICETIN | PIM1, MYRICETIN, TRANSFERASE
2o64:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 WITH QUERCETAGETIN | PIM1, QUERCETAGETIN, TRANSFERASE
2o65:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 WITH PENTAHYDROXYFLAVONE | PIM1, PENTAHYDROXYFLAVONE, TRANSFERASE
5csp:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH COMPOUND 5 BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
5csv:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH COMPOUND 6 BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
5ct0:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH 3-(3-CHLORO-4-(PHENYL)BENZYLAMINO) PROPAN-1-OL BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
1xqz:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HPIM-1 KINASE AT 2.1 A RESOLUTION | PROTEIN KINASE FOLD, TRANSFERASE
1xr1:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HPIM-1 KINASE IN COMPLEX WITH AMP-PNP AT 2.1 A RESOLUTION | PROTEIN KINASE FOLD, TRANSFERASE
5cu2:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH 2-HYDROXY-5-METHYLBENZOIC ACID AND (METHYL 4-((3-(3-CHLORO-4-(PHENYL)BENZYLAMINO)PROPYL)AMINO)-4- OXOBUTANOAT BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
5cvg:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH A NOVEL CLOSED CONFORMATION OF THE AD LOOP | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
4a9r:A (GLU321) to (LEU375) CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR | TRANSFERASE, KINASE
4a9s:A (GLU321) to (LEU375) CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR | TRANSFERASE
4a9t:A (LYS320) to (GLY376) CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR | TRANSFERASE
4a9u:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR | TRANSFERASE
3kf4:A (SER336) to (MET388) STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE | ABL, CML, DRUG RESISTANCE, INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, ONCOGENE, TYROSINE-PROTEIN KINASE, TRANSFERASE
3kf4:B (SER336) to (MET388) STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE | ABL, CML, DRUG RESISTANCE, INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, ONCOGENE, TYROSINE-PROTEIN KINASE, TRANSFERASE
5cx9:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH (METHYL 4-((3-(3-CHLORO-4-(PHENYL) BENZYLAMINO)PROPYL)AMINO)-4-OXOBUTANOATE BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
2zv7:A (LEU341) to (ILE392) LYN TYROSINE KINASE DOMAIN, APO FORM | LYN KINASE, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2zv8:A (LEU341) to (ILE392) LYN TYROSINE KINASE DOMAIN-AMP-PNP COMPLEX | LYN KINASE AMPPNP, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2zv9:A (LEU341) to (VAL391) LYN TYROSINE KINASE DOMAIN-PP2 COMPLEX | LYN KINASE PP2, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2zva:A (LEU341) to (ILE392) LYN TYROSINE KINASE DOMAIN-DASATINIB COMPLEX | LYN KINASE DASATINIB, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4afj:A (MET162) to (GLN206) 5-ARYL-4-CARBOXAMIDE-1,3-OXAZOLES: POTENT AND SELECTIVE GSK-3 INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
4afj:B (MET162) to (GLN206) 5-ARYL-4-CARBOXAMIDE-1,3-OXAZOLES: POTENT AND SELECTIVE GSK-3 INHIBITORS | TRANSFERASE-PEPTIDE COMPLEX, KINASE
3kmm:A (ILE338) to (ILE389) STRUCTURE OF HUMAN LCK KINASE WITH A SMALL MOLECULE INHIBITOR | TYROSINE KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2zyb:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF PHENYLIMIDAZO PYRAZIN 2 BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, KINASE, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, CELL MEMBRANE, POLYMORPHISM
1yhs:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM-1 BOUND TO STAUROSPORINE | PROTEIN KINASE, PROTO-ONCOGENE, TRANSFERASE
1yhw:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH ONE POINT MUTATIONS (K299R) | KINASE; ACTIVE CONFORMATION; ACTIVATION LOOP; ATP BINDING SITE, SIGNALING PROTEIN, TRANSFERASE
1yi3:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM-1 BOUND TO LY294002 | PROTEIN KINASE, PI3K, TRANSFERASE
3a7h:A (ASP117) to (THR170) HUMAN MST3 KINASE IN COMPLEX WITH ATP | TWO-LOBE PROTEIN KINASE FOLD, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, TRANSFERASE
3a7h:B (ASP117) to (THR170) HUMAN MST3 KINASE IN COMPLEX WITH ATP | TWO-LOBE PROTEIN KINASE FOLD, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, TRANSFERASE
3a7g:A (GLU118) to (THR170) HUMAN MST3 KINASE | TWO-LOBE PROTEIN KINASE FOLD, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, TRANSFERASE
3a7i:A (GLU118) to (THR170) HUMAN MST3 KINASE IN COMPLEX WITH ADENINE | TWO-LOBE PROTEIN KINASE FOLD, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, TRANSFERASE
3a7j:A (ASP117) to (ASP171) HUMAN MST3 KINASE IN COMPLEX WITH MNADP | TWO-LOBE PROTEIN KINASE FOLD ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, TRANSFERASE
3a8w:B (PRO342) to (GLY394) CRYSTAL STRUCTURE OF PKCIOTA KINASE DOMAIN | PROTEIN KINASE C IOTA, KINASE DOMAIN, ATP COMPLEX, TRANSFERASE
3a99:A (GLN140) to (LEU192) STRUCTURE OF PIM-1 KINASE CRYSTALLIZED IN THE PRESENCE OF P27KIP1 CARBOXY-TERMINAL PEPTIDE | PIM-1, P27KIP1, PEPTIDE DRUG, PROSTATE CANCER, TRANSFERASE
3kxx:A (SER596) to (HIS649) STRUCTURE OF THE MUTANT FIBROBLAST GROWTH FACTOR RECEPTOR 1 | KINASE, RTK, INTERFACE, PHOSPHORYLATION, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, CRANIOSYNOSTOSIS, DISEASE MUTATION, DISULFIDE BOND, DWARFISM, GLYCOPROTEIN, HEPARIN-BINDING, HYPOGONADOTROPIC HYPOGONADISM, IMMUNOGLOBULIN DOMAIN, KALLMANN SYNDROME, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3kxz:A (THR337) to (GLU390) THE COMPLEX CRYSTAL STRUCTURE OF LCK WITH A PROBE MOLECULE W259 | LCK, ACETYLATION, ATP-BINDING, CELL MEMBRANE, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, KINASE, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, TRANSFERASE, TYROSINE-PROTEIN KINASE, STRUCTURAL GENOMICS, PROTEIN STRUCTURE FACTORY, PSF
3ac3:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF PYRAZOLO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ac5:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF TRIAZOLO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ac8:A (ILE338) to (GLU390) CRYSTAL STRUCTURE OF PYRAZOLO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3acj:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF IMIDAZO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ack:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF PYRROLO PYRAZINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ad4:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF METHOXY BENZOFURAN DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3l0r:A (ALA15) to (PRO62) CRYSTAL STRUCTURE OF SALIVARY CYSTATIN FROM THE SOFT TICK ORNITHODOROS MOUBATA | SOFT TICK, CYSTATIN, PROTEASE INHIBITOR, THIOL PROTEASE INHIBITOR, HYDROLASE INHIBITOR
3l0r:B (ALA15) to (PRO62) CRYSTAL STRUCTURE OF SALIVARY CYSTATIN FROM THE SOFT TICK ORNITHODOROS MOUBATA | SOFT TICK, CYSTATIN, PROTEASE INHIBITOR, THIOL PROTEASE INHIBITOR, HYDROLASE INHIBITOR
5dfp:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF PAK1 IN COMPLEX WITH AN INHIBITOR COMPOUND FRAX1036 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dgz:A (GLN140) to (LEU192) DISCOVERY OF 3,5-SUBSTITUTED 6-AZAINDAZOLES AS POTENT PAN-PIM INHIBITORS | PIM-1, KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dh3:B (LYS128) to (ASP173) CRYSTAL STRUCTURE OF MST2 IN COMPLEX WITH XMU-MP-1 | MST2, MST1, HIPPO PATHWAY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dhj:A (GLN140) to (LEU192) PIM1 IN COMPLEX WITH CPD4 (3-METHYL-5-(PYRIDIN-3-YL)-1H-PYRAZOLO[3,4- C]PYRIDINE) | PIM-1, KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dia:A (GLN140) to (LEU192) PIM1 IN COMPLEX WITH CPD36 ((1S,3S)-N1-(6-(5-(PYRIDIN-3-YL)-1H- PYRAZOLO[3,4-C]PYRIDIN-3-YL)PYRIDIN-2-YL)CYCLOHEXANE-1,3-DIAMINE) | PIM-1, KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3agl:A (ALA147) to (ARG190) COMPLEX OF PKA WITH THE BISUBSTRATE PROTEIN KINASE INHIBITOR ARC-1039 | PKA, PROTEIN KINASE A, BISUBSTRATE INHIBITOR, ARC-1039, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
1ywv:A (GLU141) to (LEU192) CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA | SER/THR PROTEIN KINASE, TRANSFERASE
1yxs:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION | SER/THR PROTEIN KINASE, TRANSFERASE
1yxt:A (GLU141) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMPPNP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:B (GLN140) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:C (GLN140) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:D (GLU141) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxv:A (GLU141) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH 3,4-DIHYDROXY-1- METHYLQUINOLIN-2(1H)-ONE | SER/THR PROTEIN KINASE, TRANSFERASE
1yxx:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH (3E)-3-[(4- HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | SER/THR PROTEIN KINASE, TRANSFERASE
5dls:A (GLU104) to (ARG156) IDENTIFICATION OF NOVEL, IN VIVO ACTIVE CHK1 INHIBITORS UTILIZING STRUCTURE GUIDED DRUG DESIGN | CHK1, V158411, FRAGMENT, KINASE, TRANSFERASE
4pni:A (PRO289) to (ALA341) BOVINE G PROTEIN-COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH GSK2163632A | AGC FAMILY KINASE, SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, HYDROLYASE, GPCR, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4alu:A (GLN140) to (LEU192) BENZOFUROPYRIMIDINONE INHIBITORS OF PIM-1 | PROTO-ONCOGENE, TRANSFERASE
4alv:A (GLU141) to (LEU192) BENZOFUROPYRIMIDINONE INHIBITORS OF PIM-1 | PROTO-ONCOGENE, TRANSFERASE
4alw:A (GLN140) to (LEU192) BENZOFUROPYRIMIDINONE INHIBITORS OF PIM-1 | TRANSFERASE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1
3lh4:A (GLU18) to (GLU67) CRYSTAL STRUCTURE OF SIALOSTATIN L2 | BETA SHEET, CYSTATIN, PROTEASE INHIBITOR, THIOL PROTEASE INHIBITOR, HYDROLASE INHIBITOR
1zar:A (PRO195) to (VAL242) CRYSTAL STRUCTURE OF A.FULGIDUS RIO2 KINASE COMPLEXED WITH ADP AND MANGANESE IONS | SERINE KINASE, WINGED-HELIX, RIO DOMAIN, ADP-MN COMPLEX, RRNA PROCESSING, TRANSFERASE
3lj1:A (ILE775) to (SER837) IRE1 COMPLEXED WITH CDK1/2 INHIBITOR III | KINASE, KINASE INHIBITOR, NUCLEASE ACTIVATOR, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3lj1:B (ILE775) to (SER837) IRE1 COMPLEXED WITH CDK1/2 INHIBITOR III | KINASE, KINASE INHIBITOR, NUCLEASE ACTIVATOR, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3lm5:A (SER131) to (ILE186) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE 17B (STK17B) IN COMPLEX WITH QUERCETIN | STK17B, SERINE/THREONINE KINASE 17B, DRAK2, DAP KINASE RELATED APOPTOSIS-INDUCING PROTEIN KINASE 2, DEATH-ASSOCIATED PROTEIN KINASE-RELATED 2, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, APOPTOSIS, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
5dwr:A (GLN140) to (LEU192) IDENTIFICATION OF N-(4-((1R,3S,5S)-3-AMINO-5-METHYLCYCLOHEXYL)PYRIDIN- 3-YL)-6-(2,6-DIFLUOROPHENYL)-5-FLUOROPICOLINAMIDE (PIM447), A POTENT AND SELECTIVE PROVIRAL INSERTION SITE OF MOLONEY MURINE LEUKEMIA (PIM) 1,2 AND 3 KINASE INHIBITOR IN CLINICAL TRIALS FOR HEMATOLOGICAL MALIGNANCIES | PIM1, MOLONEY MURINE LEUKEMIA, PIM447, KINASE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4as0:A (GLU141) to (LEU192) CYCLOMETALATED PHTHALIMIDES AS PROTEIN KINASE INHIBITORS | TRANSFERASE, PIM1, OCTASPORINE, RUTHENIUM, KINASE INHIBITOR
1zlt:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHK1 COMPLEXED WITH A HYMENALDISINE ANALOG | KINASE, TRANSFERASE
1zp9:A (VAL172) to (LEU219) CRYSTAL STRUCTURE OF FULL-LEGNTH A.FULGIDUS RIO1 SERINE KINASE BOUND TO ATP AND MN2+ IONS. | RIO1, RIOK1, SERINE KINASE, PROTEIN KINASE, MANGANESE, RIBOSOME BIOGENESIS, TRANSFERASE
1zp9:C (ASP171) to (LEU219) CRYSTAL STRUCTURE OF FULL-LEGNTH A.FULGIDUS RIO1 SERINE KINASE BOUND TO ATP AND MN2+ IONS. | RIO1, RIOK1, SERINE KINASE, PROTEIN KINASE, MANGANESE, RIBOSOME BIOGENESIS, TRANSFERASE
1zp9:D (ASP171) to (LEU219) CRYSTAL STRUCTURE OF FULL-LEGNTH A.FULGIDUS RIO1 SERINE KINASE BOUND TO ATP AND MN2+ IONS. | RIO1, RIOK1, SERINE KINASE, PROTEIN KINASE, MANGANESE, RIBOSOME BIOGENESIS, TRANSFERASE
4q5j:A (TRP980) to (SER1035) CRYSTAL STRUCTURE OF SEMET DERIVATIVE BRI1 IN COMPLEX WITH BKI1 | KINASE DOMAIN, ATP BINDING, PHOSPHORYLATION, SEMET LABELLED, MEMBRANE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4q5j:B (TRP980) to (SER1035) CRYSTAL STRUCTURE OF SEMET DERIVATIVE BRI1 IN COMPLEX WITH BKI1 | KINASE DOMAIN, ATP BINDING, PHOSPHORYLATION, SEMET LABELLED, MEMBRANE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5e1e:A (LEU977) to (THR1030) HUMAN JAK1 KINASE IN COMPLEX WITH COMPOUND 30 AT 2.30 ANGSTROMS RESOLUTION | KINASE, TRANSFERASE
1zth:A (VAL172) to (LEU219) CRYSTAL STRUCTURE OF A.FULGIDUS RIO1 SERINE PROTEIN KINASE BOUND TO ADP AND MANGANESE ION | PROTEIN KINASE, RIBOSOME BIOGENESIS, RRNA, ADP, MANGANESE, TRANSFERASE
1zth:C (ASP171) to (LEU219) CRYSTAL STRUCTURE OF A.FULGIDUS RIO1 SERINE PROTEIN KINASE BOUND TO ADP AND MANGANESE ION | PROTEIN KINASE, RIBOSOME BIOGENESIS, RRNA, ADP, MANGANESE, TRANSFERASE
1zys:A (GLU104) to (ARG156) CO-CRYSTAL STRUCTURE OF CHECKPOINT KINASE CHK1 WITH A PYRROLO-PYRIDINE INHIBITOR | CHK1; CRYSTAL STRUCTURE, SIGNALING PROTEIN, TRANSFERASE
3av5:A (SER1421) to (TRP1521) CRYSTAL STRUCTURE OF MOUSE DNA METHYLTRANSFERASE 1 WITH ADOHCY | CXXC-TYPE ZINC FINGER/C5-METHYLTRANSFERASE FAMILY, METHYLATES CPG RESIDUES, PREFERENTIALLY METHYLATES HEMIMETHYLATED DNA, DNA BINDING, HEMI-METHYLATION, NUCLEUS, TRANSFERASE
3av6:A (SER1421) to (TRP1521) CRYSTAL STRUCTURE OF MOUSE DNA METHYLTRANSFERASE 1 WITH ADOMET | CXXC-TYPE ZINC FINGER/C5-METHYLTRANSFERASE FAMILY, METHYLATES CPG RESIDUES, PREFERENTIALLY METHYLATES HEMIMETHYLATED DNA, DNA BINDING, HEMI-METHYLATION, NUCLEUS, TRANSFERASE
2a2a:B (GLU113) to (ASP170) HIGH-RESOLUTION CRYSTALLOGRAPHIC ANALYSIS OF THE AUTOINHIBITED CONFORMATION OF A HUMAN DEATH-ASSOCIATED PROTEIN KINASE | PROTEIN KINASE, AUTOINHIBITION, TRANSFERASE
4b99:A (LEU156) to (LEU207) CRYSTAL STRUCTURE OF MAPK7 (ERK5) WITH INHIBITOR | TRANSFERASE, INHIBITOR
3ma3:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A NAPHTHO-DIFURAN LIGAND | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE, CELL CYCLE, CELL MEMBRANE
4qml:A (GLU118) to (ASP171) MST3 IN COMPLEX WITH AMP-PNP | PROTEIN KINASE, MST3, STK24, STERILE 20-LIKE KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qmn:A (GLU118) to (THR170) MST3 IN COMPLEX WITH BOSUTINIB | PROTEIN KINASE, MST3, STK24, STERILE 20-LIKE KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qmy:A (GLU118) to (THR170) MST3 IN COMPLEX WITH STAUROSPORINE | PROTEIN KINASE, MST3, STK24, STERILE 20-LIKE KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qna:A (GLU118) to (THR170) MST3 IN COMPLEX WITH 2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)PHENOL | PROTEIN KINASE, MST3, STK24, STERILE 20-LIKE KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qo9:B (GLU118) to (THR170) MST3 IN COMPLEX WITH DANUSERTIB | PROTEIN KINASE, MST3, STK24, STERILE 20-LIKE KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4bda:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
4bdb:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
4bdc:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
4bdd:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE, INHIBITOR
4bde:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
4bdf:A (LYS320) to (GLU377) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE, INHIBITOR
4bdg:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE, INHIBITOR
4bdh:A (LYS320) to (GLY376) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
4bdk:A (LYS320) to (GLY376) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
5eol:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A MACROCYCLIC QUINOXALINE-PYRROLODIHYDROPIPERIDINONE INHIBITOR | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3bgq:A (GLN140) to (LEU192) HUMAN PIM-1 KINASE IN COMPLEX WITH AN TRIAZOLO PYRIDAZINE INHIBITOR VX2 | KINASE INHIBITOR PHOSPHORYLATION, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3bgz:A (GLN140) to (LEU192) HUMAN PIM-1 KINASE IN COMPLEX WITH DIPHENYL INDOLE INHIBITOR VX3 | KINASE INHIBITOR PHOSPHORYLATION, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3bqc:A (THR129) to (PHE181) HIGH PH-VALUE CRYSTAL STRUCTURE OF EMODIN IN COMPLEX WITH THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 | PROTEIN KINASE CK2, CASEIN KINASE 2, EUKARYOTIC PROTEIN KINASES, EMODIN, ATP-COMPETITIVE INHIBITOR, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
3bqr:A (LEU120) to (ALA170) CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND | DEATH ASSOCIATED KINASE, DAPK3, ZIP KINASE, ZIPK, DAP KINASE 3, DAP LIKE KINASE, DLK, STRUCTURAL GENOMICS CONSORTIUM, SGC, APOPTOSIS, ATP-BINDING, CHROMATIN REGULATOR, NUCLEOTIDE-BINDING, NUCLEUS, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4qye:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN IN COMPLEX WITH DIARYLPYRAZINE COMPOUND 1 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qyf:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN IN COMPLEX WITH AMINOPYRAZINE COMPOUND 13 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5f4n:A (GLU104) to (ARG156) MULTI-PARAMETER LEAD OPTIMIZATION TO GIVE AN ORAL CHK1 INHIBITOR CLINICAL CANDIDATE: (R)-5-((4-((MORPHOLIN-2-YLMETHYL)AMINO)-5- (TRIFLUOROMETHYL)PYRIDIN-2-YL)AMINO)PYRAZINE-2-CARBONITRILE (CCT245737) | INHIBITOR DNA-DAMAGE CHK1-POTENCY HERG-ACTIVITY, TRANSFERASE
4qyg:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN IN COMPLEX WITH DIAZACARBAZOLE COMPOUND 14 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qyg:B (GLU104) to (ARG156) CHK1 KINASE DOMAIN IN COMPLEX WITH DIAZACARBAZOLE COMPOUND 14 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qyh:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN IN COMPLEX WITH DIAZACARBAZOLE GNE-783 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qyh:B (GLU104) to (ARG156) CHK1 KINASE DOMAIN IN COMPLEX WITH DIAZACARBAZOLE GNE-783 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3mwz:A (GLU19) to (GLU68) CRYSTAL STRUCTURE OF THE SELENOMETHIONINE DERIVATIVE OF THE L 22,47, 100 M MUTANT OF SIALOSTATIN L2 | ANTIPARALLEL BETA-SHEET, HYDROLASE INHIBITOR
5f94:A (MET162) to (GLN206) CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH COMPOUND 15: 2- [(CYCLOPROPYLCARBONYL)AMINO]-N-(4-METHOXYPYRIDIN-3-YL)PYRIDINE-4- CARBOXAMIDE | GSK3B, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3bwf:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AN OSMIUM COMPOUND | TRANSFERASE, PIM1, KINASE, ATP-BINDING, PHOSPHORYLATION, ALTERNATIVE INITIATION, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE
3byo:A (ILE338) to (ILE389) X-RAY CO-CRYSTAL STRUCTURE OF 2-AMINO-6-PHENYLPYRIMIDO[5', 4':5,6]PYRIMIDO[1,2-A]BENZIMIDAZOL-5(6H)-ONE 25 BOUND TO LCK | LCK, KINASE DOMAIN, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3c4e:A (GLU141) to (LEU192) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4e:B (GLN140) to (LEU192) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4e:C (GLN140) to (LEU192) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4e:D (GLN140) to (LEU192) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4x:A (GLU288) to (ALA341) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ATP AND MAGNESIUM CHLORIDE AT 2.9A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4x:B (GLU288) to (ALA341) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ATP AND MAGNESIUM CHLORIDE AT 2.9A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4y:A (PRO289) to (LYS340) CRYSTAL STRUCTURE OF APO FORM OF G PROTEIN COUPLED RECEPTOR KINASE 1 AT 7.51A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4y:B (PRO289) to (LYS340) CRYSTAL STRUCTURE OF APO FORM OF G PROTEIN COUPLED RECEPTOR KINASE 1 AT 7.51A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c50:A (GLU288) to (ALA341) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ADP AND MAGNESIUM CHLORIDE AT 2.6A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ADP, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c50:B (GLU288) to (LEU339) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ADP AND MAGNESIUM CHLORIDE AT 2.6A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ADP, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c51:A (GLU288) to (LEU339) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ADP AND MAGNESIUM CHLORIDE AT 3.55A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ADP, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4bzn:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH A PYRROLO(1,2-A) PYRAZINONE INHIBITOR | PIM1, ATP BINDING, KINASE INHIBITOR, TRANSFERASE
4rbl:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
4rc2:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
4rc3:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE DOMAIN, KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
4rc4:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
4c3p:D (ASP229) to (HIS280) STRUCTURE OF DEPHOSPHORYLATED AURORA A (122-403) BOUND TO TPX2 AND AMPPCP | TRANSFERASE, ACTIVATION, ALLOSTERY, CELL CYCLE, CANCER
4rix:D (SER787) to (GLY839) CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-Q790R MUTATION | RECEPTOR TYROSINE KINASE, PSEUDOKINASE, KINASE, ATP BINDING, MEMBRANE, TRANSFERASE
4rll:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF HUMAN CK2ALPHA IN COMPLEX WITH THE ATP- COMPETITIVE INHIBITOR 4-[(E)-(FLUOREN-9-YLIDENEHYDRAZINYLIDENE)- METHYL] BENZOATE | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3com:B (THR122) to (THR175) CRYSTAL STRUCTURE OF MST1 KINASE | KINASE, MST1, SERINE/THREONINE-PROTEIN KINASE 4, STE20-LIKE KINASE, PSI, STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC, ALTERNATIVE SPLICING, APOPTOSIS, ATP- BINDING, COILED COIL, CYTOPLASM, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, TRANSFERASE
4rpv:A (GLN140) to (LEU192) CO-CRYSTAL STRUCTURE OF PIM1 WITH COMPOUND 3 | PIM1, KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3nyn:A (GLU285) to (PRO337) CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 6 IN COMPLEX WITH SANGIVAMYCIN | KINASE, GRK, RGS HOMOLOGY DOMAIN, G PROTEIN-COUPLED RECEPTOR KINASE, TRANSFERASE
3nyn:B (PRO284) to (PRO337) CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 6 IN COMPLEX WITH SANGIVAMYCIN | KINASE, GRK, RGS HOMOLOGY DOMAIN, G PROTEIN-COUPLED RECEPTOR KINASE, TRANSFERASE
3nyo:A (PRO284) to (PRO337) CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 6 IN COMPLEX WITH AMP | KINASE, GRK, RGS HOMOLOGY DOMAIN, G PROTEIN-COUPLED RECEPTOR KINASE, TRANSFERASE
3nyo:B (PRO284) to (PRO337) CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 6 IN COMPLEX WITH AMP | KINASE, GRK, RGS HOMOLOGY DOMAIN, G PROTEIN-COUPLED RECEPTOR KINASE, TRANSFERASE
4rvk:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN WITH DIAZACARBAZOLE COMPOUND 8: N-[3-(6-CYANO-9H- PYRROLO[2,3-B:5,4-C']DIPYRIDIN-3-YL)PHENYL]ACETAMIDE | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rvm:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN WITH DIAZACARBAZOLE COMPOUND 19 | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3cxw:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A BETA CARBOLINE LIGAND I | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE
3cy2:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A BETA CARBOLINE LIGAND II | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE
3cy3:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND THE JNK INHIBITOR V | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE
3d5u:A (ARG144) to (PHE189) CRYSTAL STRUCTURE OF A WILDTYPE POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN. | POLO-LIKE KINASE 1, PLK1, CATALYTIC DOMAIN, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
3d5v:A (ARG144) to (GLU188) CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN. | POLO-LIKE KINASE 1, PLK1, CATALYTIC DOMAIN, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
3d5w:A (ARG144) to (GLU188) CRYSTAL STRUCTURE OF A PHOSPHORYLATED POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH ADP. | POLO-LIKE KINASE 1, PLK1, CATALYTIC DOMAIN, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
3d5x:A (ARG144) to (PHE189) CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH WORTMANNIN. | POLO-LIKE KINASE 1, PLK1, CATALYTIC DOMAIN, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
3d7t:B (LEU360) to (ARG409) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK SRC TYROSINE KINASE, ATP-BINDING, CYTOPLASM, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, PROTO- ONCOGENE
3dcv:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM1 KINASE COMPLEXED WITH 4-(4- HYDROXY-3-METHYL-PHENYL)-6-PHENYLPYRIMIDIN-2(1H)-ONE | SER/THR PROTEIN KINASE, NUCLEOTIDE-BINDING, PHSPHORYLATION, ATP-BINDING, CANCER, ONCOGENE, ALTERNATIVE INITIATION, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4cxa:C (SER832) to (LEU883) CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLIN K COMPLEX BOUND TO AMPPNP | TRANSFERASE, KINASE
3ofm:A (THR130) to (PHE182) STRUCTURE OF A HUMAN CK2ALPHA PRIME, THE PARALOG ISOFORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM HOMO SAPIENS | EUKARYPTIC PROTEIN KINASE FOLD, PHOSPHO TRANSFERASE, ATP BINDING, PHOSPHORYLATION, CYTOPLASM AND NUCLEUS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3dk3:B (SER336) to (THR389) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3dk6:B (SER336) to (THR389) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
4d2v:B (PHE113) to (LYS158) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN
4txc:A (LEU120) to (PHE170) CRYSTAL STRUCTURE OF DAPK1 KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR | PROTEIN-LIGAND COMPLEX, KINASE, SMALL-MOLECULE, CATALYTIC DOMAIN, PROTEIN KINASE, PROTEIN BINDING, PROTEIN KINASE INHIBITORS, TRANSFERASE
4ty1:A (GLU141) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH AN AMINOOXADIAZOLE-INDOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
3dqx:A (PRO361) to (ILE411) CHICKEN C-SRC KINASE DOMAIN IN COMPLEX WITH ATPGS | SRC, KINASE, ACTIVE, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3ot3:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 22K BOUND TO HUMAN CHK1 KINASE DOMAIN | KINASE, PHOSPHATASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ot8:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 17R BOUND TO HUMAN CHK1 KINASE DOMAIN | KINASE, PHOSPHATASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5he0:A (SER290) to (SER343) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG215022 | RGS, KINASE, PH, WD-40, INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4dhf:A (ASP229) to (ALA281) STRUCTURE OF AURORA A MUTANT BOUND TO BIOGENIDEC CPD 15 | SER/THR KINASE MITOTIC KINASE PYRAZOLOPYRIMIDINE, PHOSPHORYLATION, TPX2, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u6r:A (GLU664) to (LEU718) CRYSTAL STRUCTURE OF HUMAN IRE1 CYTOPLASMIC DOMAINS IN COMPLEX WITH A SULFONAMIDE INHIBITOR. | TRANSFERASE, KINASE, HYDROLASE, ENDORIBONUCLEASE
3pa3:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 70 BOUND TO HUMAN CHK1 KINASE DOMAIN | KINASE, PHOSPHATASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pa4:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 2A BOUND TO HUMAN CHK1 KINASE DOMAIN | KINASE, PHOSPHATASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pa5:A (GLU104) to (ARG156) X-RAY CRYSTAL STRUCTURE OF COMPOUND 1 BOUND TO HUMAN CHK1 KINASE DOMAIN | KINASE, PHOSPHATASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4dtk:A (GLN140) to (LEU192) NOVEL AND SELECTIVE PAN-PIM KINASE INHIBITOR | PIM1, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4un0:D (SER832) to (TYR884) CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX | TRANSFERASE
4e26:B (GLU549) to (LYS601) BRAF IN COMPLEX WITH AN ORGANIC INHIBITOR 7898734 | KINASE, INHIBITOR, ONCOPROTEIN, MELANOMA, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e3c:C (ILE122) to (LEU173) X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVE CONFORMATION | KANASE, AUTO-PHOSPHORYLATION, NEMO BINDING, TRANSFERASE
4e3c:D (ILE122) to (LEU173) X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVE CONFORMATION | KANASE, AUTO-PHOSPHORYLATION, NEMO BINDING, TRANSFERASE
4e3c:E (ILE122) to (GLU172) X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVE CONFORMATION | KANASE, AUTO-PHOSPHORYLATION, NEMO BINDING, TRANSFERASE
4e3c:F (ILE122) to (LEU173) X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVE CONFORMATION | KANASE, AUTO-PHOSPHORYLATION, NEMO BINDING, TRANSFERASE
3ppk:B (GLU549) to (VAL600) HUMAN B-RAF KINASE IN COMPLEX WITH A NON-OXIME FUROPYRIDINE INHIBITOR | PROTEIN KINASE, B-RAF ATP-COMPETITIVE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3ppz:A (ASP647) to (ALA702) CRYSTAL STRUCTURE OF CTR1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE | KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE
3prf:A (GLU549) to (VAL600) CRYSTAL STRUCTURE OF HUMAN B-RAF KINASE DOMAIN IN COMPLEX WITH A NON- OXIME FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3prf:B (GLU549) to (VAL600) CRYSTAL STRUCTURE OF HUMAN B-RAF KINASE DOMAIN IN COMPLEX WITH A NON- OXIME FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5iis:A (GLN140) to (LEU192) DESIGN, SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP OF POTENT PAN- PIM KINASE INHIBITORS DERIVED FROM THE PYRIDYL-AMIDE SCAFFOLD | PIM1, MOLONEY MURINE LEUKEMIA, PIM447, KINASE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3psd:A (GLU549) to (VAL600) NON-OXIME PYRAZOLE BASED INHIBITORS OF B-RAF KINASE | KINASE, ATP-BINDING, CARDIOMYOPATHY, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, ZINC-FINGER, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3psd:B (GLU549) to (VAL600) NON-OXIME PYRAZOLE BASED INHIBITORS OF B-RAF KINASE | KINASE, ATP-BINDING, CARDIOMYOPATHY, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, ZINC-FINGER, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3pt9:A (SER1421) to (TRP1521) CRYSTAL STRUCTURE OF MOUSE DNMT1(731-1602) IN THE FREE STATE | MAINTENANCE DNA METHYLATION, TRANSFERASE
3pvu:A (SER290) to (SER343) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND A SELECTIVE KINASE INHIBITOR (CMPD101) | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, INHIBITOR, MEMBRANE, TRANSFERASE-SIGNALING PROTEIN-INHIBITOR COMPLEX
5ime:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF P21-ACTIVATED KINASE 1 (PAK1) IN COMPLEX WITH COMPOUND 9 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5ipj:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A QUINAZOLINONE-PYRROLOPYRROLONE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q1f:B (GLY217) to (GLN252) CTX-M-9 S70G IN COMPLEX WITH HYDROLYZED PIPERACILLIN | BETA-LACTAMASE, ESBL, CTX-M, CTX-M-9, BETA-LACTAM, PIPERACILLIN, MICHAELIS, ANTIBIOTIC RESISTANCE, HYDROLASE, ALPHA BETA FOLD, HYDROLASE-ANTIBIOTIC COMPLEX
4enx:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM-1 KINASE IN COMPLEX WITH INHIBITOR (2E,5Z)-2- (2-CHLOROPHENYLIMINO)-5-(4-HYDROXY-3-NITROBENZYLIDENE)THIAZOLIDIN-4- ONE | PIM-1 KINASE, TRANSFERASE-INHIBITOR COMPLEX
4eny:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM-1 KINASE IN COMPLEX WITH (2E,5Z)-2-(2- CHLOROPHENYLIMINO)-5-(4-HYDROXY-3-METHOXYBENZYLIDENE)THIAZOLIDIN-4- ONE | PIM-1 KINASE, TRANSFERASE-INHIBITOR COMPLEX
3q4c:B (MET549) to (VAL599) CRYSTAL STRUCTURE OF WILD TYPE BRAF KINASE DOMAIN IN COMPLEX WITH ORGANOMETALLIC INHIBITOR CNS292 | KINASE, INHIBITOR, ONCOPROTEIN, MELANOMA, KINASE-KINASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4eqc:A (ASP362) to (THR415) CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN IN COMPLEX WITH FRAX597 INHIBITOR | SERINE/THREONINE KINASE, PHOSPHORYLATION, ATP-BINDING, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3q52:A (GLU363) to (THR415) STRUCTURE OF PHOSPHORYLATED PAK1 KINASE DOMAIN | KINASE DOMAIN, SIGNALLING PATHWAY, TRANSFERASE
4euu:A (GLU109) to (LEU164) STRUCTURE OF BX-795 COMPLEXED WITH HUMAN TBK1 KINASE DOMAIN PHOSPHORYLATED ON SER172 | KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4euu:B (GLU109) to (LEU164) STRUCTURE OF BX-795 COMPLEXED WITH HUMAN TBK1 KINASE DOMAIN PHOSPHORYLATED ON SER172 | KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q9w:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH EMODIN AT PH 8.5 | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q9z:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH QUINALIZARIN AT PH 6.5 | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qa0:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF THE APO-FORM OF HUMAN CK2 ALPHA AT PH 6.5 | PROTEIN KINASE, APO-FORM, TRANSFERASE
4ewh:B (LEU229) to (GLN279) CO-CRYSTAL STRUCTURE OF ACK1 WITH INHIBITOR | DRUG DESIGN, ENZYME INHIBITORS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qc9:A (PRO289) to (ALA341) CRYSTAL STRUCTURE OF CROSS-LINKED BOVINE GRK1 T8C/N480C DOUBLE MUTANT COMPLEXED WITH ADP AND MG | ENKARYOTIC PROTEIN KINASE FOLD, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
3qc9:B (PRO289) to (ALA341) CRYSTAL STRUCTURE OF CROSS-LINKED BOVINE GRK1 T8C/N480C DOUBLE MUTANT COMPLEXED WITH ADP AND MG | ENKARYOTIC PROTEIN KINASE FOLD, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
3qc9:C (PRO289) to (ALA341) CRYSTAL STRUCTURE OF CROSS-LINKED BOVINE GRK1 T8C/N480C DOUBLE MUTANT COMPLEXED WITH ADP AND MG | ENKARYOTIC PROTEIN KINASE FOLD, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
3qc9:D (PRO289) to (ALA341) CRYSTAL STRUCTURE OF CROSS-LINKED BOVINE GRK1 T8C/N480C DOUBLE MUTANT COMPLEXED WITH ADP AND MG | ENKARYOTIC PROTEIN KINASE FOLD, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4f0f:A (TRP1126) to (SER1184) CRYSTAL STRUCTURE OF THE ROCO4 KINASE DOMAIN BOUND TO APPCP FROM D. DISCOIDEUM | PROTEIN KINASE, LRRK2, ROCO, KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SIGNALING PROTEIN
3qf9:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A FURAN- THIAZOLIDINEDIONE LIGAND | TRANSFERASE/PEPTIDE, COMPLEX TRANSFERASE-PEPTIDE, PIM1,KINASE, CANCER, LEUKEMIA, ATP-BINDING, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
5j79:A (TRP118) to (ARG171) THE IDENTIFICATION AND PHARMACOLOGICAL CHARACTERIZATION OF 6-(TERT- BUTYLSULFONYL)-N-(5-FLUORO-1H-INDAZOL-3-YL)QUINOLIN-4-AMINE (GSK583), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF RIP2 KINASE, COMPOUND 3 COMPLEX | KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5j79:B (TRP118) to (ARG171) THE IDENTIFICATION AND PHARMACOLOGICAL CHARACTERIZATION OF 6-(TERT- BUTYLSULFONYL)-N-(5-FLUORO-1H-INDAZOL-3-YL)QUINOLIN-4-AMINE (GSK583), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF RIP2 KINASE, COMPOUND 3 COMPLEX | KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fif:B (GLU414) to (SER466) CATALYTIC DOMAIN OF HUMAN PAK4 WITH RPKPLVDP PEPTIDE | SERINE/THREONINE-PROTEIN KINASE PAK4, KINASE DOMAIN, PROTEIN KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-PEPTIDE COMPLEX
3r00:A (GLN140) to (LEU192) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r01:A (GLU141) to (LEU192) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINASE, PIM1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r02:A (GLN140) to (LEU192) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINASE, PIM1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r04:A (GLN140) to (LEU192) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINAE, PIM1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r1n:A (THR139) to (THR195) MK3 KINASE BOUND TO COMPOUND 5B | KINASE DOMAIN WITH BOUND INHIBITOR, KINASE DOMAIN, PHOSPHOTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3re4:A (ASP171) to (LEU219) CRYSTAL STRUCTURE OF ARCHAEOGLOBUS FULGIDUS RIO1 KINASE BOUND TO TOYOCAMYCIN. | ATYPICAL KINASE, TRANSFERASE-ANTIBIOTIC COMPLEX
5jm8:D (THR391) to (PRO453) THE STRUCTURE OF ATP-BOUND AEROBACTIN SYNTHETASE IUCA FROM A HYPERVIRULENT PATHOTYPE OF KLEBSIELLA PNEUMONIAE | AEROBACTIN NIS SYNTHETASE, LIGASE
5jm8:G (THR391) to (PRO453) THE STRUCTURE OF ATP-BOUND AEROBACTIN SYNTHETASE IUCA FROM A HYPERVIRULENT PATHOTYPE OF KLEBSIELLA PNEUMONIAE | AEROBACTIN NIS SYNTHETASE, LIGASE
5jm8:H (THR391) to (PRO453) THE STRUCTURE OF ATP-BOUND AEROBACTIN SYNTHETASE IUCA FROM A HYPERVIRULENT PATHOTYPE OF KLEBSIELLA PNEUMONIAE | AEROBACTIN NIS SYNTHETASE, LIGASE
4fsm:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsq:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsr:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fst:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsw:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsy:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsz:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ft0:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ft3:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ft5:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ft7:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fta:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftc:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftj:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftl:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftm:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftn:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fto:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftq:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftr:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftt:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftu:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4g3f:A (PRO490) to (CYS542) CRYSTAL STRUCTURE OF MURINE NF-KAPPAB INDUCING KINASE (NIK) BOUND TO A 2-(AMINOTHIAZOLY)PHENOL (CMP2) | NON-RD KINASE, PROTEIN SERINE/THREONINE KINASE, NF-KAPPAB, STRUCTURE- BASED DRUG DESIGN, MAP3K14, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5kbq:A (GLU363) to (THR415) PAK1 IN COMPLEX WITH BIS-ANILINO PYRIMIDINE INHIBITOR | SERINE/THREONINE-PROTEIN KINASE PAK1, KINASE, TRANSFERASE
4gh2:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5lpb:A (TRP980) to (SER1035) CRYSTAL STRUCTURE OF THE BRI1 KINASE DOMAIN (865-1160) IN COMPLEX WITH ADP FROM ARABIDOPSIS THALIANA | BRASSINOSTEROID RECEPTOR, KINASE DOMAIN, DUAL-SPECIFICIFY KINASE, MEMBRANE RECEPTOR KINASE, PLASMA MEMBRANE, TRANSFERASE
5lpv:A (TRP980) to (SER1035) CRYSTAL STRUCTURE OF THE BRI1 KINASE DOMAIN (865-1160) IN COMPLEX WITH AMPPNP AND MN FROM ARABIDOPSIS THALIANA | BRASSINOSTEROID RECEPTOR, KINASE DOMAIN, DUAL-SPECIFICIFY KINASE, MEMBRANE RECEPTOR KINASE, PLASMA MEMBRANE, TRANSFERASE
5tf9:A (LYS320) to (LYS375) CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH MN2+AMPPNP AND WNK476 | SERINE-THREONINE-PROTEIN KINASE, INHIBITOR, TERNARY, COMPLEX, ALLOSTERIC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2oi4:X (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH FLUORINATED RUTHENIUM PYRIDOCARBAZOLE | TRANSFERASE,PIM1,KINASE, ATP-BINDING,PHOSPHORYLATION
4wt6:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A THIADIAZOLAMINE-INDOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE
2bik:B (GLN140) to (LEU192) HUMAN PIM1 PHOSPHORYLATED ON SER261 | KINASE, CANCER, LEUKEMIA, TRANSFERASE, ATP-BINDING
2bro:A (GLU104) to (ARG156) STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY | DRUG DESIGN, FURANOPYRIMIDINE, MOLECULAR RECOGNITION, ONCOLOGY, PYRROLOPYRIMIDINE, ATP-BINDING, CELL CYCLE, DNA DAMAGE, KINASE, NUCLEAR PROTEIN, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3sdm:A (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:B (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:C (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:D (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:E (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:F (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:G (PRO774) to (SER837) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
2c3l:A (GLU104) to (ARG156) IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION | DRUG DESIGN, MOLECULAR MODELING, MOLECULAR RECOGNITION, ONCOLOGY, ATP-BINDING, CELL CYCLE, DNA DAMAGE, DNA REPAIR, KINASE, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, UBL CONJUGATION
2pvf:A (THR599) to (ILE651) CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED ACTIVATED FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN IN COMPLEX WITH ATP ANALOG AND SUBSTRATE PEPTIDE | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, TRANSFERASE
2pzi:B (ALA251) to (ILE300) CRYSTAL STRUCTURE OF PROTEIN KINASE PKNG FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH TETRAHYDROBENZOTHIOPHENE AX20017 | SERINE/THREONINE-PROTEIN KINASE, ATP-RECOGNITION, KINASE-INHIBITOR COMPLEX, RUBREDOXIN FOLD, TPR DOMAIN, TRANSFERASE
3g6h:A (PRO361) to (ILE411) SRC THR338ILE INHIBITED IN THE DFG-ASP-OUT CONFORMATION | CANCER, IMATINIB RESISTANCE, DSA COMPOUNDS, KINASE, DFG-ASP- OUT, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
2cn5:A (GLU321) to (LEU375) CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP | TRANSFERASE, KINASE, KINASE DOMAIN, CHECKPOINT, CANCER, TUMOUR SUPPRESSOR, CHEK2, CHK2, CDS1, RAD53, PHOSPHORYLATION, ACTIVATION SEGMENT, LI-FRAUMENI SYNDROME, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, MAGNESIUM, METAL-BINDING, NUCLEAR PROTEIN, NUCLEOTIDE- BINDING, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE
2qoh:A (SER336) to (MET388) CRYSTAL STRUCTURE OF ABL KINASE BOUND WITH PPY-A | ABL, KINASE, INHIBITOR, TRANSFERASE
3t9i:A (GLN140) to (LEU192) PIM1 COMPLEXED WITH A NOVEL 3,6-DISUBSTITUTED INDOLE AT 2.6 ANG RESOLUTION | KINASE, PHOSPHOTRANSFERASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tkh:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHK1 IN COMPLEX WITH INHIBITOR S01 | CHK1, KINASE, CELL CHECKPOINT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4jdh:A (GLU414) to (SER466) CRYSTAL STRUCTURE OF SERINE/THREONINE-PROTEIN KINASE PAK 4 IN COMPLEX WITH PAKTIDE T PEPTIDE SUBSTRATE | TRANSFERASE-PEPTIDE COMPLEX, TRANSFERASE/PEPTIDE, SERINE/THREONINE- PROTEIN KINASE PAK4, ATP BINDING, PHOSPHORYLATION
3to3:A (ILE407) to (TYR464) CRYSTAL STRUCTURE OF PETROBACTIN BIOSYNTHESIS PROTEIN ASBB FROM BACILLUS ANTHRACIS STR. STERNE | STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER FOR STRUCTURAL GENOMICS, MCSG, ALPHA-BETA STRUCTURE, ADENYLATION, CYTOSOL, BIOSYNTHETIC PROTEIN
3to3:B (GLU408) to (TYR464) CRYSTAL STRUCTURE OF PETROBACTIN BIOSYNTHESIS PROTEIN ASBB FROM BACILLUS ANTHRACIS STR. STERNE | STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER FOR STRUCTURAL GENOMICS, MCSG, ALPHA-BETA STRUCTURE, ADENYLATION, CYTOSOL, BIOSYNTHETIC PROTEIN
2e9p:A (GLU104) to (ARG156) STRUCTURE OF H-CHK1 COMPLEXED WITH A771129 | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
2v5q:A (LEU157) to (TYR203) CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN | DESIGN ANKYRIN REPEAT PROTEIN, TRANSFERASE COMPLEX, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, KINASE, NUCLEUS, TRANSFERASE, ATP-BINDING, SERINE/THREONINE PROTEIN KINASE
2v5q:B (GLU150) to (TYR203) CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN | DESIGN ANKYRIN REPEAT PROTEIN, TRANSFERASE COMPLEX, PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, KINASE, NUCLEUS, TRANSFERASE, ATP-BINDING, SERINE/THREONINE PROTEIN KINASE
3hmi:A (THR382) to (LEU433) THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH 5-AMINO-3-{[4- (AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4- TRIAZOLE-1-CARBOTHIOAMIDE | TYROSINE KINASE, ABL, ABL2, ABELSON MURINE LEUKEMIA VIRAL ONCOGENE, ATP-BINDING, CELL ADHESION, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
4yzc:A (ILE666) to (LEU718) CRYSTAL STRUCTURE OF PIRE1ALPHA IN COMPLEX WITH STAUROSPORINE | IRE1, INHIBITOR, STAUROSPORINE, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yzc:B (ILE666) to (LEU718) CRYSTAL STRUCTURE OF PIRE1ALPHA IN COMPLEX WITH STAUROSPORINE | IRE1, INHIBITOR, STAUROSPORINE, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2g2f:B (ASN336) to (THR389) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
2vwb:A (ASP430) to (ILE473) STRUCTURE OF THE ARCHAEAL KAE1-BUD32 FUSION PROTEIN MJ1130: A MODEL FOR THE EUKARYOTIC EKC-KEOPS SUBCOMPLEX INVOLVED IN TRANSCRIPTION AND TELOMERE HOMEOSTASIS. | HYDROLASE, EKC, KAE1, BUD32, KEOPS, MJ1130, PROTEASE, TELOMERE, METALLOPROTEASE
2ghg:A (PRO103) to (ARG156) H-CHK1 COMPLEXED WITH A431994 | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
2w03:A (ASP412) to (ASP473) CO-COMPLEX STRUCTURE OF ACHROMOBACTIN SYNTHETASE PROTEIN D ( ACSD) WITH ADENOSINE, SULFATE AND CITRATE FROM PECTOBACTERIUM CHRYSANTHEMI | SSPF, ACSD, ACHROMOBACTIN BIOSYNTHESIS, METAL TRANSPORT, PECTOBACTERIUM CHRYSANTHEMI
2w7x:A (LYS320) to (GLY376) CELLULAR INHIBITION OF CHECKPOINT KINASE 2 AND POTENTIATION OF CYTOTOXIC DRUGS BY NOVEL CHK2 INHIBITOR PV1019 | CO-CRYSTAL STRUCTURE, KINASE, NUCLEUS, MAGNESIUM, CELL CYCLE, ATP-BINDING, LI-FRAUMENI SYNDROME, SERINE/THREONINE-PROTEIN KINASE, DISEASE MUTATION, NUCLEOTIDE-BINDING, TRANSFERASE, POTENTIATION, METAL-BINDING, PROTO-ONCOGENE, PHOSPHOPROTEIN, CHK2 INHIBITOR
1tqp:A (PRO195) to (VAL242) CRYSTAL STRUCTURE OF A. FULGIDUS RIO2 SERINE PROTEIN KINASE BOUND TO ATP | SERINE KINASE, RIBOSOME
4zy6:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF P21-ACTIVATED KINASE 1 IN COMPLEX WITH AN INHIBITOR COMPOUND 29 | PAK1, KINASE, INHIBITOR, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lm5:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH 2-{4-[(3-AMINOPROPYL) AMINO]QUINAZOLIN-2-YL}PHENOL (RESULTING FROM DISPLACEMENT OF SKF86002) | CO-CRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2wk0:A (GLY217) to (PRO254) CRYSTAL STRUCTURE OF THE CLASS A BETA-LACTAMASE BS3 INHIBITED BY 6-BETA-IODOPENICILLANATE. | HYDROLASE, BETA- LACTAMASE, IODOPENICILLANATE, ANTIBIOTIC RESISTANCE, BACILLUS LICHENIFORMIS
2hog:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 20 | CHEK1, KINASE, CELL CYCLE CHECKPOINT, TRANSFERASE
2wmx:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | SERINE/THREONINE-PROTEIN KINASE, POLYMORPHISM, PHOSPHOPROTEIN, UBL CONJUGATION, ISOPEPTIDE BOND, CHECKPOINT KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE KINASE, DNA DAMAGE, DNA REPAIR, ATP-BINDING, TRANSFERASE, CHK1, KINASE, NUCLEUS, CYTOPLASM, CELL CYCLE
2hxl:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 1 | CHEK1, KINASE, CELL CYCLE CHECKPOINT, TRANSFERASE
2hy0:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHEK1 IN COMPLEX WITH INHIBITOR 22 | CHEK1, KINASE, CELL CYCLE CHECKPOINT, TRANSFERASE
2hy8:1 (GLU363) to (THR415) PAK1 COMPLEX WITH ST2001 | TYPICAL FOLD OF SER/THR KINASES. INHIBITOR IS BOUND BETWEEN THE N-TERMINAL AND C-TERMINAL DOMAINS., TRANSFERASE
2wti:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, KINASE, CELL CYCLE, LI-FRAUMENI SYNDROME
2wtj:A (LYS320) to (LEU375) CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, KINASE, CELL CYCLE, LI-FRAUMENI SYNDROME
2x0g:A (GLU113) to (LYS167) X-RAY STRUCTURE OF A DAP-KINASE CALMODULIN COMPLEX | TRANSFERASE-SIGNALING PROTEIN COMPLEX, TRANSFERASE SIGNALING PROTEIN COMPLEX, PHOSPHOPROTEIN, CALMODULIN-BINDING, DAPK, KINASE, ANK REPEAT, CALMODULIN, TRANSFERASE, ATP-BINDING
4md7:E (THR129) to (PHE181) CRYSTAL STRUCTURE OF FULL-LENGTH SYMMETRIC CK2 HOLOENZYME | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4md7:F (THR129) to (PHE181) CRYSTAL STRUCTURE OF FULL-LENGTH SYMMETRIC CK2 HOLOENZYME | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4md7:G (THR129) to (PHE181) CRYSTAL STRUCTURE OF FULL-LENGTH SYMMETRIC CK2 HOLOENZYME | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4md7:H (THR129) to (PHE181) CRYSTAL STRUCTURE OF FULL-LENGTH SYMMETRIC CK2 HOLOENZYME | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
2x0o:A (THR433) to (ASN478) APO STRUCTURE OF THE ALCALIGIN BIOSYNTHESIS PROTEIN C (ALCC) FROM BORDETELLA BRONCHISEPTICA | BIOSYNTHETIC PROTEIN, ALCALIGIN BIOSYNTHESIS, ADENYLATION, SIDEROPHORES, IRON ACQUISITION
4md9:G (THR129) to (PHE181) CRYSTAL STRUCTURE OF SYMMETRIC CK2 HOLOENZYME WITH MUTATED ALPHA SUBUNIT (F121E TRUNCATED AT AA 336) | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4md9:K (THR129) to (PHE181) CRYSTAL STRUCTURE OF SYMMETRIC CK2 HOLOENZYME WITH MUTATED ALPHA SUBUNIT (F121E TRUNCATED AT AA 336) | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
4md9:M (THR129) to (PHE181) CRYSTAL STRUCTURE OF SYMMETRIC CK2 HOLOENZYME WITH MUTATED ALPHA SUBUNIT (F121E TRUNCATED AT AA 336) | PROTEIN SERINE/THREONINE KINASE, TRANSFERASE
2xf0:A (PRO103) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, CELL CYCLE
4mta:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM-1 KINASE DOMAIN IN COMPLEX WITH 2-METHYL-5- PHENYLFURAN-3-CARBOXYLIC ACID | SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, TRANSFERASE
2xj0:A (GLN140) to (LEU192) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-4 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | PHOSPHORYLATION, TRANSFERASE
2xj2:A (GLN140) to (LEU192) PROTEIN KINASE PIM-1 IN COMPLEX WITH SMALL MOLECULE INHIBITOR | TRANSFERASE, PHOSPHORYLATION, PROTEIN KINASE FOLD
4mxo:A (LEU360) to (ILE411) HUMAN SRC KINASE BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mxy:B (PRO361) to (ILE411) SRC M314L T338M DOUBLE MUTANT BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4n6y:A (GLN140) to (LEU192) PIM1 COMPLEXED WITH A PHENYLCARBOXAMIDE | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4nm3:A (VAL155) to (GLN206) CRYSTAL STRUCTURE OF GSK-3/AXIN COMPLEX BOUND TO PHOSPHORYLATED N- TERMINAL AUTO-INHIBITORY PS9 PEPTIDE | WNT, LRP6, AUTO-INHIBITED, GSK-3, AXIN, KINASE, PRIMED SUBSTRATE, PHOSPHORYLATED N-TERMINAL AUTO-INHIBITORY PS9 PEPTIDE, TRANSFERASE- PEPTIDE COMPLEX
2y7j:A (ARG135) to (GLU179) STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2 | TRANSFERASE
2yer:A (PRO103) to (ARG156) SYNTHESIS AND EVALUATION OF TRIAZOLONES AS CHECKPOINT KINASE 1 INHIBITORS | TRANSFERASE
2yex:A (GLU104) to (ARG156) SYNTHESIS AND EVALUATION OF TRIAZOLONES AS CHECKPOINT KINASE 1 INHIBITORS | TRANSFERASE, CELL CYCLE, CHK
2yir:A (LYS320) to (GLY376) STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 IN COMPLEX WITH INHIBITOR PV1352 | TRANSFERASE, STRUCTURE-BASED DRUG DESIGN
3jpv:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A PYRROLO[2,3- A]CARBAZOLE LIGAND | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, PYRROLO[2,3-A]CARBAZOLE, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP- BINDING, CELL MEMBRANE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, TRANSFERASE - TRANSFERASE INHIBITOR COMPLEX
2ym3:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR
2ym4:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, SERINE/THREONINE KINASE
2ym6:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS | TRANSFERASE, DNA REPAIR, CELL CYCLE
3jvr:A (GLU104) to (ARG156) CHARACTERIZATION OF THE CHK1 ALLOSTERIC INHIBITOR BINDING SITE | PROTEIN KINASE, ATP-BINDING, CELL CYCLE, CYTOPLASM, DNA DAMAGE, DNA REPAIR, ISOPEPTIDE BOND, KINASE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, UBL CONJUGATION
3jy0:A (GLN140) to (LEU192) DISCOVERY OF 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONES AS POTENT, HIGHLY SELECTIVE AND ORALLY BIOAVAILABLE PIM KINASES INHIBITORS | PIM-1, ALTERNATIVE INITIATION, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, KINASE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
1lr4:A (THR129) to (PHE181) ROOM TEMPERATURE CRYSTAL STRUCTURE OF THE APO-FORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM ZEA MAYS | PROTEIN KINASE, CK2, CASEIN KINASE 2, DUAL-COSUBSTRATE SPECIFICITY, TRANSFERASE
4a4l:A (LEU157) to (TYR203) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO-PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR | TRANSFERASE
4a7c:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 KINASE WITH ETP46546 | TRANSFERASE, PROTEIN KINASE, INHIBITOR
3kc3:G (GLY171) to (THR215) MK2 COMPLEXED TO INHIBITOR N4-(7-(BENZOFURAN-2-YL)-1H-INDAZOL-5-YL) PYRIMIDINE-2,4-DIAMINE | MAPKAP-K2, MK2, TNFALPHA, DIAMINOPYRIMIDINE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3kc3:I (GLU172) to (THR214) MK2 COMPLEXED TO INHIBITOR N4-(7-(BENZOFURAN-2-YL)-1H-INDAZOL-5-YL) PYRIMIDINE-2,4-DIAMINE | MAPKAP-K2, MK2, TNFALPHA, DIAMINOPYRIMIDINE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3kc3:K (THR159) to (THR214) MK2 COMPLEXED TO INHIBITOR N4-(7-(BENZOFURAN-2-YL)-1H-INDAZOL-5-YL) PYRIMIDINE-2,4-DIAMINE | MAPKAP-K2, MK2, TNFALPHA, DIAMINOPYRIMIDINE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
5ctp:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH N-(3-(3-CHLORO-4-(PHENYL) BENZYLAMINO)PROPYL)ACETAMIDE BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
5cu4:A (THR129) to (PHE181) CRYSTAL STRUCTURE OF CK2ALPHA WITH COMPOUND 10 BOUND | CK2ALPHA, CK2A, FRAGMENT BASED DRUG DISCOVERY, HIGH CONCENTRATION SCREENING, SELECTIVE ATP COMPETITIVE INHIBITORS, SURFACE ENTROPHY REDUCTION, TRANSFERASE
2zm4:A (ILE338) to (GLU390) CRYSTAL STRUCTURE OF IMIDAZO QUINOXALINE 1 BOUND TO THE KINASE DOMAIN OF HUMAN LCK, ACTIVATED FORM (AUTO- PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE- BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
1xws:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN | PIM1, KINASE, CANCER, LEUKEMIA, TRANSFERASE
3a2c:D (GLU160) to (THR215) CRYSTAL STRUCTURE OF A PYRAZOLOPYRIMIDINE INHIBITOR COMPLEX BOUND TO MAPKAP KINASE-2 (MK2) | GLY-RICH LOOP FORMED, AIPHA-HELIX, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
5dey:A (GLU363) to (THR415) CRYSTAL STRUCTURE OF PAK1 IN COMPLEX WITH AN INHIBITOR COMPOUND G-5555 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ad6:A (ILE338) to (ILE389) CRYSTAL STRUCTURE OF PYRAZOLO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
1yrp:A (LEU120) to (GLU169) CATALYTIC DOMAIN OF HUMAN ZIP KINASE PHOSPHORYLATED AT THR265 | KINASE FOLD, PHOSPHOTHREONINE, TRANSFERASE
1yrp:B (LEU120) to (GLU169) CATALYTIC DOMAIN OF HUMAN ZIP KINASE PHOSPHORYLATED AT THR265 | KINASE FOLD, PHOSPHOTHREONINE, TRANSFERASE
3lj2:A (ILE775) to (LEU835) IRE1 COMPLEXED WITH JAK INHIBITOR I | KINASE, KINASE INHIBITOR, NUCLEASE ACTIVATOR, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3lm0:A (GLU132) to (ILE186) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE 17B (STK17B) | STK17B, SERINE/THREONINE KINASE 17B, DRAK2, DAP KINASE RELATED APOPTOSIS-INDUCING PROTEIN KINASE 2, DEATH-ASSOCIATED PROTEIN KINASE-RELATED 2, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, APOPTOSIS, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4bdi:A (LYS320) to (GLY376) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
4bdj:A (LYS320) to (LEU375) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
3bgp:A (GLN140) to (LEU192) HUMAN PIM-1 COMPLEXED WITH A BENZOISOXAZOLE INHIBITOR VX1 | KINASE INHIBITOR PHOSPHORYLATION, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c13:A (THR129) to (PHE181) LOW PH-VALUE CRYSTAL STRUCTURE OF EMODIN IN COMPLEX WITH THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 | PROTEIN KINASE CK2, CASEIN KINASE 2, EUKARYOTIC PROTEIN KINASES, EMODIN, ATP-COMPETITIVE INHIBITOR, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, WNT SIGNALING PATHWAY
3c4z:A (PRO289) to (LEU339) CRYSTAL STRUCTURE OF G PROTEIN COUPLED RECEPTOR KINASE 1 BOUND TO ADP AND MAGNESIUM CHLORIDE AT 1.84A | SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, P-LOOP, AUTOPHOSPHORYLATION, ADP, ATP-BINDING, LIPOPROTEIN, MEMBRANE, METHYLATION, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4bzo:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH A PYRROLO- PYRAZINONE INHIBITOR | PIM1, ATP BINDING, KINASE INHIBITOR, TRANSFERASE
3ckx:A (GLU103) to (THR155) CRYSTAL STRUCTURE OF STERILE 20-LIKE KINASE 3 (MST3, STK24) IN COMPLEX WITH STAUROSPORINE | STRUCTURAL GENOMICS, PSI-2, PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER FOR STRUCTURAL GENOMICS, NYSGXRC, PROTEIN KINASE, MST3, STK24, STERILE 20-LIKE KINASE, STAUROSPORINE, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3nlb:A (PRO103) to (ARG156) NOVEL KINASE PROFILE HIGHLIGHTS THE TEMPORAL BASIS OF CONTEXT DEPENDENT CHECKPOINT PATHWAYS TO CELL DEATH | KINASE DOMAIN, CHECKPOINT KINASE, ATP BINDING, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rvl:A (GLU104) to (ARG156) CHK1 KINASE DOMAIN WITH DIAZACARBAZOLE COMPOUND 7: 3-(2- HYDROXYPHENYL)-9H-PYRROLO[2,3-B:5,4-C']DIPYRIDINE-6-CARBONITRILE | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4d0x:A (ILE951) to (GLN1003) PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS | TRANSFERASE, DRUG DISCOVERY, PROTEIN KINASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, POLYCYTHEMIA VERA, TUMOUR CELL PROLIFERATION INHIBITION, ANTI-CANCER AGENTS
3dk7:A (SER336) to (LEU387) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3dk7:B (SER336) to (LEU387) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
4d2t:A (PHE113) to (ALA171) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN, KINASE
4d2t:B (PHE113) to (LYS158) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN, KINASE
4d2t:C (PHE113) to (LYS156) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN, KINASE
4u8z:A (GLU118) to (THR170) CRYSTAL STRUCTURE OF MST3 WITH A PYRROLOPYRIMIDINE INHIBITOR (PF- 06447475) | MST3, PYRROLOPYRIMIDINE, INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ppj:A (GLU549) to (VAL600) HUMAN B-RAF KINASE IN COMPLEX WITH A FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ppj:B (GLU549) to (VAL600) HUMAN B-RAF KINASE IN COMPLEX WITH A FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3psb:A (GLU549) to (VAL600) FURO[2,3-C]PYRIDINE-BASED INDANONE OXIMES AS POTENT AND SELECTIVE B- RAF INHIBITORS | KINASE, ATP-BINDING, CARDIOMYOPATHY, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, ZINC-FINGER, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3q9x:B (THR129) to (PHE181) CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH EMODIN AT PH 6.5 | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r2b:E (GLY171) to (THR215) MK2 KINASE BOUND TO COMPOUND 5B | KINASE DOMAIN WITH BOUND INHIBITOR, KINASE DOMAIN, PHOSPHOTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r2y:A (THR159) to (THR215) MK2 KINASE BOUND TO COMPOUND 1 | KINASE DOMAIN, PHOSPHOTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsn:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fsu:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ft9:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fti:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ftk:A (GLU104) to (ARG156) CRYSTAL STRUCTURE OF THE CHK1 | TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5kzi:A (GLN140) to (LEU192) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH AN IMIDAZOPYRIDAZINE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX