2o8t:A (GLN192) to (THR242) CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q) IN COMPLEX WITH INHIBITORS | UROKINASE-TYPE PLASMINOGEN ACTIVATOR, BENZAMIDINE, PHENYLGUANIDINE, CONTACT AREA, HYDROLASE
2o8w:A (GLN192) to (THR242) CRYSTAL STRUCTURE AND BINDING EPITOPES OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (C122A/N145Q/S195A) IN COMPLEX WITH INHIBITORS | UROKINASE-TYPE PLASMINOGEN ACTIVATOR, BENZAMIDINE, PHENYLGUANIDINE, CONTACT AREA, HYDROLASE
1a7s:A (ASN172) to (ASN219) ATOMIC RESOLUTION STRUCTURE OF HBP | SERINE PROTEASE HOMOLOG, ENDOTOXIN BINDING, HEPARIN
1ao5:A (ARG192) to (ALA246) MOUSE GLANDULAR KALLIKREIN-13 (PRORENIN CONVERTING ENZYME) | GLANDULAR KALLIKREIN, SERINE PROTEASE, PROTEIN MATURATION
1ao5:B (ARG192) to (ALA246) MOUSE GLANDULAR KALLIKREIN-13 (PRORENIN CONVERTING ENZYME) | GLANDULAR KALLIKREIN, SERINE PROTEASE, PROTEIN MATURATION
1arb:A (PRO191) to (GLY236) THE PRIMARY STRUCTURE AND STRUCTURAL CHARACTERISTICS OF ACHROMOBACTER LYTICUS PROTEASE I, A LYSINE-SPECIFIC SERINE PROTEASE | HYDROLASE(SERINE PROTEASE)
2bdb:A (GLN192) to (TYR234) PORCINE PANCREATIC ELASTASE COMPLEXED WITH ASN-PRO-ILE AND ALA-ALA AT PH 5.0 | SERINE PROTEINASE, HYDROLASE
2bdh:A (ASN192) to (VAL242) HUMAN KALLIKREIN 4 COMPLEX WITH ZINC AND P-AMINOBENZAMIDINE | SERINE PROTEINASE, S1 SUBSITE, 70-80 LOOP, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
2bdh:C (ASN192) to (VAL242) HUMAN KALLIKREIN 4 COMPLEX WITH ZINC AND P-AMINOBENZAMIDINE | SERINE PROTEINASE, S1 SUBSITE, 70-80 LOOP, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
2bdi:A (ASN192) to (ALA244) HUMAN KALLIKREIN 4 COMPLEX WITH COBALT AND P- AMINOBENZAMIDINE | SERINE PROTEINASE, S1 SUBSITE, 70-80 LOOP, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
2bdi:J (ASN192) to (GLN243) HUMAN KALLIKREIN 4 COMPLEX WITH COBALT AND P- AMINOBENZAMIDINE | SERINE PROTEINASE, S1 SUBSITE, 70-80 LOOP, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
2bdi:M (ASN192) to (ALA244) HUMAN KALLIKREIN 4 COMPLEX WITH COBALT AND P- AMINOBENZAMIDINE | SERINE PROTEINASE, S1 SUBSITE, 70-80 LOOP, STRUCTURAL PROTEOMICS IN EUROPE, SPINE, STRUCTURAL GENOMICS, HYDROLASE
2pfe:A (GLY192) to (PHE238) CRYSTAL STRUCTURE OF THERMOBIFIDA FUSCA PROTEASE A (TFPA) | BETA-BARRELS; SERINE PROTEASE; THERMOPHILE; KINETIC STABILITY; THERMOSTABILITY; PROTEIN FOLDING; ALPHA-LYTIC PROTEASE; FOLDING TRANSITION STATE STRUCTURE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pfe:B (GLY192) to (PHE238) CRYSTAL STRUCTURE OF THERMOBIFIDA FUSCA PROTEASE A (TFPA) | BETA-BARRELS; SERINE PROTEASE; THERMOPHILE; KINETIC STABILITY; THERMOSTABILITY; PROTEIN FOLDING; ALPHA-LYTIC PROTEASE; FOLDING TRANSITION STATE STRUCTURE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bma:A (GLN200) to (ASN255) BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE | SERINE PROTEASE,METAL-BINDING, PROTEASE, SECRETED, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c1m:A (GLN192) to (ASN245) PORCINE ELASTASE UNDER XENON PRESSURE (8 BAR) | SERINE PROTEASE, HYDROLASE, PANCREAS ELASTASE, XENON
1c1n:A (GLN192) to (VAL235) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c1q:A (GLN192) to (ASN245) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c1r:A (GLN192) to (VAL235) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pka:B (MET192) to (THR243) REFINED 2 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF PORCINE PANCREATIC KALLIKREIN A, A SPECIFIC TRYPSIN-LIKE SERINE PROTEINASE. CRYSTALLIZATION, STRUCTURE DETERMINATION, CRYSTALLOGRAPHIC REFINEMENT, STRUCTURE AND ITS COMPARISON WITH BOVINE TRYPSIN | SERINE PROTEINASE
2pka:Y (MET192) to (THR243) REFINED 2 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF PORCINE PANCREATIC KALLIKREIN A, A SPECIFIC TRYPSIN-LIKE SERINE PROTEINASE. CRYSTALLIZATION, STRUCTURE DETERMINATION, CRYSTALLOGRAPHIC REFINEMENT, STRUCTURE AND ITS COMPARISON WITH BOVINE TRYPSIN | SERINE PROTEINASE
1c2d:A (GLN192) to (ASN245) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1c2f:A (GLN192) to (VAL235) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c2l:A (GLN192) to (VAL235) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c2m:A (GLN192) to (ASN245) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c5s:A (GLN192) to (VAL235) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1- BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, HYDROLASE
1c5t:A (GLN192) to (ASN245) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1- BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, HYDROLASE
1c5v:A (GLN192) to (ASN245) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1- BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, HYDROLASE
2cv3:A (GLN200) to (TYR244) CRYSTAL STRUCTURE OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH A MACROCLYCLIC PEPTIDE INHIBITOR | PROTEIN-INHIBITOR INTERACTION, MACROCYCLIC PEPTIDE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1dpo:A (GLN192) to (ASN245) STRUCTURE OF RAT TRYPSIN | HYDROLASE, SERINE PROTEASE, DIGESTION, PANCREAS, ZYMOGEN, SIGNAL, MULTIGENE FAMILY
1e35:B (GLN192) to (TYR234) PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-TOLUENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR TWO MINUTES | HYDROLASE(SERINE PROTEASE), SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1e37:B (GLN192) to (ASN245) PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR 1 MINUTE | HYDROLASE(SERINE PROTEASE), SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1eas:A (GLN192) to (TYR234) NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN- 2-ONE TRIFLUOROMETHYL KETONES | HYDROLASE (SERINE PROTEASE)
1eat:A (GLN192) to (ILE242) NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5- AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES | HYDROLASE (SERINE PROTEASE)
1eau:A (GLN192) to (ASN245) NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE | HYDROLASE (SERINE PROTEASE)
1qgf:A (GLN192) to (ASN245) PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3R, 4S)N-PARA- TOLUENESULPHONYL-3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2- ONE | SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1elf:A (GLN200) to (ASN255) NATURE OF THE INACTIVATION OF ELASTASE BY N-PEPTIDYL-O- AROYL HYDROXYLAMINE AS A FUNCTION OF PH | COMPLEX (HYDROLASE/INHIBITOR)
4jk5:A (GLN192) to (LEU235) HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) IN COMPLEX WITH A BICYCLIC PEPTIDE INHIBITOR (UK18-D-SER) | SERINE PROTEASE, CHYMOTRYPSIN FOLD, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, BICYCLIC PEPTIDE INHIBITOR, D-AMINO ACID, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3h5x:A (ASP354) to (TYR416) CRYSTAL STRUCTURE OF 2'-AMINO-2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE BOUND TO NOROVIRUS GII RNA POLYMERASE | POLYMERASE-RNA COMPLEX, NON-NATURAL NUCLEOSIDE TRIPHOSPHATE ANALOG, CALICIVIRUS, HYDROLASE, NUCLEOTIDE-BINDING, NUCLEOTIDYLTRANSFERASE, PROTEASE, RNA REPLICATION, RNA-DIRECTED RNA POLYMERASE, THIOL PROTEASE, TRANSFERASE, TRANSFERASE-RNA COMPLEX
3h5y:A (ASP354) to (TYR416) NOROVIRUS POLYMERASE+PRIMER/TEMPLATE+CTP COMPLEX AT 6 MM MNCL2 | CALICIVIRUSES, VIRAL RNA POLYMERASE, HYDROLASE, NUCLEOTIDE-BINDING, NUCLEOTIDYLTRANSFERASE, PROTEASE, RNA REPLICATION, RNA-DIRECTED RNA POLYMERASE, THIOL PROTEASE, TRANSFERASE, TRANSFERASE-RNA COMPLEX
2ea3:A (PRO134) to (TYR176) CRYSTAL STRUCTURE OF CELLULOMONAS BOGORIENSIS CHYMOTRYPSIN | CELLOULOMONAS, CHYMOTRYPSIN, PROTEASE, HYDROLASE
4jz1:A (GLN192) to (ASN241) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR | MATRIPTASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3hgn:A (GLN192) to (TYR234) STRUCTURE OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH A POTENT PEPTIDYL INHIBITOR FR130180 DETERMINED BY NEUTRON CRYSTALLOGRAPHY | CHYMOTRYPSIN FAMILY, HYDROLASE, SERINE PROTEASE, DISULFIDE BOND, METAL-BINDING, PROTEASE, SECRETED, ZYMOGEN
2v0b:A (GLN185) to (TYR229) SAD STRUCTURE SOLUTION PORCINE PANCREATIC ELASTASE FROM A SELENATE DERIVATIVE | HYDROLASE, SERINE PROTEASE, CRYSTALLIZATION, SUBSTITUTION, METAL-BINDING, SE, SAD, CALCIUM, ZYMOGEN, PROTEASE, SELENATE
1fiz:A (GLN192) to (LYS241) THREE DIMENSIONAL STRUCTURE OF BETA-ACROSIN FROM BOAR SPERMATOZOA | ANTI-PARALLEL BETA-BARREL, HYDROLASE
4k5z:A (LYS192) to (ASN245) CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH FRAGMENT INHIBITOR 6-CHLORO-2,3-DIHYDRO-1H-ISOINDOL-1-ONE | SERINE PROTEASE, GLYCOSYLATED, MAST CELLS, SECRETED, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4k60:A (LYS192) to (GLN243) CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH FRAGMENT 6-BROMO-1, 3-DIHYDRO-2H-INDOL-2-ONE | SERINE PROTEASE, GLYCOSYLATED, MAST CELLS, SECRETED, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4k69:A (LYS192) to (ASN245) CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH FRAGMENT LINKED BENZIMIDAZOLONE INHIBITOR: (3S)-3-{3-[(6-BROMO-2-OXO-2,3-DIHYDRO-1H- INDOL-4-YL)METHYL]-2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOL-1-YL}HEXANOIC ACID | SERINE PROTEASE, GLYCOSYLATED, MAST CELLS, SECRETED, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1fuj:A (PHE192) to (ARG243) PR3 (MYELOBLASTIN) | HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, ZYMOGEN, HYDROLASE (SERINE PROTEASE)
1fuj:D (PHE192) to (ARG243) PR3 (MYELOBLASTIN) | HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, ZYMOGEN, HYDROLASE (SERINE PROTEASE)
1fy1:A (ASN172) to (PRO220) [R23S,F25E]HBP, A MUTANT OF HUMAN HEPARIN BINDING PROTEIN (CAP37) | SERINE PROTEASE HOMOLOG, ENDOTOXIN (LIPID A) BINDING SITE, ANTIMICROBIAL PROTEIN
4kga:B (ASN192) to (ALA244) CRYSTAL STRUCTURE OF KALLIKREIN-RELATED PEPTIDASE 4 | KLK4, KALLIKREIN-4, SERINE PROTEASE, PROTEASE, HYDROLASE
2vid:B (SER154) to (ILE202) SERINE PROTEASE SPLB FROM STAPHYLOCOCCUS AUREUS AT 1.8A RESOLUTION | PROTEASE, SERINE PROTEASE, STAPHYLOCOCCUS AUREUS, HYDROLASE
3uuz:A (GLN192) to (ASN245) BOVINE TRYPSIN VARIANT X(TRIPLEPHE227) IN COMPLEX WITH SMALL MOLECULE INHIBITOR | TRYPSIN-LIKE SERINE PROTEASE, HYDROLASE, PROTEIN BINDING, DUODENUM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uwi:A (GLN192) to (ASN245) BOVINE TRYPSIN VARIANT X(TRIPLEGLU217PHE227) IN COMPLEX WITH SMALL MOLECULE INHIBITOR | TRYPSIN-LIKE SERINE PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2fo9:A (GLN200) to (ASN255) STRUCTURE OF PORCINE PANCREATIC ELASTASE IN 95% ACETONE | ELASTASE; SOLVENT MAPPING; ORGANIC SOLVENTS; PROTEIN BINDING SITES; MULTIPLE SOLVENT CRYSTAL STRUCTURES, HYDROLASE
2foa:A (GLN200) to (ASN255) STRUCTURE OF PORCINE PANCREATIC ELASTASE IN 40/50/10 % BENZENE | ELASTASE; SOLVENT MAPPING; ORGANIC SOLVENTS; PROTEIN BINDING SITES; MULTIPLE SOLVENT CRYSTAL STRUCTURES, HYDROLASE
2fob:A (GLN200) to (ASN255) STRUCTURE OF PORCINE PANCREATIC ELASTASE IN 40/50/10 CYCLOHEXANE | ELASTASE; SOLVENT MAPPING; ORGANIC SOLVENTS; PROTEIN BINDING SITES; MULTIPLE SOLVENT CRYSTAL STRUCTURES, HYDROLASE
2fof:A (GLN200) to (ASN255) STRUCTURE OF PORCINE PANCREATIC ELASTASE IN 80% ISOPROPANOL | ELASTASE; SOLVENT MAPPING; ORGANIC SOLVENTS; PROTEIN BINDING SITES; MULTIPLE SOLVENT CRYSTAL STRUCTURES, HYDROLASE
1gj9:B (GLN192) to (LEU235) ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS | SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN, BLOOD CLOTTING, HYDROLASE
3v0x:A (GLN192) to (ASN245) BOVINE TRYPSIN VARIANT X(TRIPLEGLU217PHE227) IN COMPLEX WITH SMALL MOLECULE INHIBITOR | TRYPSIN-LIKE SERINE PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2g4u:A (GLN185) to (TYR229) ANOMALOUS SUBSTRUCTURE OF PORCINE PANCREATIC ELASTAASE (CA) | ANOMALOUS SUBSTRUCTURE OF PORCINE PANCREATIC ELASTASE (CA), HYDROLASE
1gyt:D (GLY446) to (GLY498) E. COLI AMINOPEPTIDASE A (PEPA) | HYDROLASE, PEPTIDASE, DNA RECOMBINATION, AMINOPEPTIDASE
1gyt:F (GLY446) to (GLY498) E. COLI AMINOPEPTIDASE A (PEPA) | HYDROLASE, PEPTIDASE, DNA RECOMBINATION, AMINOPEPTIDASE
1gyt:J (GLY446) to (ALA497) E. COLI AMINOPEPTIDASE A (PEPA) | HYDROLASE, PEPTIDASE, DNA RECOMBINATION, AMINOPEPTIDASE
5a0b:A (PHE192) to (ILE242) CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE IN COMPLEX WITH A DIHYDROPYRIMIDONE INHIBITOR | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE- INHIBITOR COMPLEX
5a8y:A (PHE192) to (ILE241) CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE IN COMPLEX WITH A DIHYDROPYRIMIDONE INHIBITOR | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE-INHIBITOR COMPLEX
5abw:A (PHE192) to (ILE241) NEUTROPHIL ELASTASE INHIBITORS FOR THE TREATMENT OF (CARDIO) PULMONARY DISEASES | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE-INHIBITOR COMPLEX
1uto:A (GLN192) to (VAL235) TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS | HYDROLASE, TRYPSIN, INHIBITOR SPECIFICITY, ELECTROSTATIC INTERACTIONS, COLD-ADAPTATION, MOLECULAR DYNAMICS, BINDING FREE ENERGY
1utq:A (GLN192) to (VAL235) TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS | HYDROLASE, TRYPSIN, INHIBITOR SPECIFICITY, ELECTROSTATIC INTERACTIONS, COLD-ADAPTATION, MOLECULAR DYNAMICS, BINDING FREE ENERGY HYDROLASE
2iot:A (GLN192) to (ASN245) CLAVULANIC ACID BOUND TO ELASTASE | ELASTASE CLAVULANIC ACID, HYDROLASE
1j15:A (GLN192) to (ASN245) BENZAMIDINE IN COMPLEX WITH RAT TRYPSIN MUTANT X99/175/190RT | SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1v2l:T (GLN192) to (ASN245) BENZAMIDINE IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(TRIPLE.GLU)BT.D1 | SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1v2m:T (GLN192) to (ASN245) BENZAMIDINE IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(TRIPLE.GLU)BT.A1 | SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1jim:A (GLN192) to (ASN245) STEREOSPECIFIC REACTION OF 3-METHOXY-4-CHLORO-7- AMINOISOCOUMARIN WITH CRYSTALLINE PORCINE PANCREATIC ELASTASE | HYDROLASE(SERINE PROTEINASE)
1w13:U (GLN192) to (THR242) UROKINASE TYPE PLASMINOGEN ACTIVATOR | UROKINASE, HYDROLASE, PLASMINOGEN ACTIVATOR
2k1q:A (LYS136) to (SER182) NMR STRUCTURE OF HEPATITIS C VIRUS NS3 SERINE PROTEASE COMPLEXED WITH THE NON-COVALENTLY BOUND PHENETHYLAMIDE INHIBITOR | SERINE PROTEASE, NS3, HEPATITIS C VIRUS, NON COVALENT INHIBITOR, ENVELOPE PROTEIN, HELICASE, HYDROLASE, NUCLEOTIDE-BINDING, RNA REPLICATION, TRANSMEMBRANE, VIRAL PROTEIN
4nzl:A (PHE199) to (ILE245) EXTRACELLULAR PROTEINS OF STAPHYLOCOCCUS AUREUS INHIBIT THE NEUTROPHIL SERINE PROTEASES | PRIMARILY BETA, SERINE PROTEASE, PROTEASE INHIBITOR, INNATE IMMUNITY, AZUROPHILIC GRANULES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4o97:A (GLN192) to (PHE234) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR | MATRIPTASE, TRYPSIN-LIKE SERINE PROTEINASE FOLD, PROTEASE, SMALL MOLECULE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4o9v:A (GLN192) to (ASN241) CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR | MATRIPTASE, TRYPSIN-LIKE SERINE PROTEINASE FOLD, PROTEASE, SMALL MOLECULE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2z9i:B (PRO166) to (GLY224) CRYSTAL STRUCTURE OF RV0983 FROM MYCOBACTERIUM TUBERCULOSIS- PROTEOLYTICALLY ACTIVE FORM | SERINE PROTEASE, HTRA, HYDROLASE
1lvy:A (GLN192) to (ASN245) PORCINE ELASTASE | SERINE PROTEASE, HYDROLASE, ZYMOGEN, PANCREAS
4afs:A (LYS179) to (ASN226) HUMAN CHYMASE - FYNOMER COMPLEX | HYDROLASE-DE NOVO PROTEIN COMPLEX, INHIBITOR, SERINE PROTEASE
3l33:D (GLN192) to (SER246) HUMAN MESOTRYPSIN COMPLEXED WITH AMYLOID PRECURSOR PROTEIN INHIBITOR(APPI) | HUMAN MESOTRYPSIN, ALZHEIMER'S AMYLOID PRECURSOR PROTEIN INHIBITOR, APPI, SERINE PROTEASE INHIBITOR, HYDROLASE-CELL ADHESION COMPLEX
4pro:B (ARG140) to (TYR191) ALPHA-LYTIC PROTEASE COMPLEXED WITH PRO REGION | PRO REGION, FOLDASE, PROTEIN FOLDING, SERINE PROTEASE
5eg4:A (GLN192) to (ASN245) BOVINE TRYPSIN IN COMPLEX WITH CYCLIC INHIBITOR | METAL-BINDING, DIGESTION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE
4qpx:A (ASP354) to (TYR416) NV POLYMERASE POST-INCORPORATION-LIKE COMPLEX | RNA-DEPEDENT RNA POLYMERASE, HYDROLASE-RNA COMPLEX
3mmg:A (ASP148) to (ALA193) CRYSTAL STRUCTURE OF TOBACCO VEIN MOTTLING VIRUS PROTEASE | 3C-TYPE PROTEASE, TEV, TVMV, VIRAL PROTEIN, HYDROLASE
3mmg:B (ASP148) to (ALA193) CRYSTAL STRUCTURE OF TOBACCO VEIN MOTTLING VIRUS PROTEASE | 3C-TYPE PROTEASE, TEV, TVMV, VIRAL PROTEIN, HYDROLASE
5etx:C (LYS1136) to (MET1179) CRYSTAL STRUCTURE OF HCV NS3/4A PROTEASE A156T VARIANT IN COMPLEX WITH 5172-LINEAR (MK-5172 LINEAR ANALOGUE) | MACROCYCLIZATION, MK-5172 ANALOGUE, GRAZOPREVIR, HCV PROTEASE INHIBITOR RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3bsn:A (ASP354) to (TYR416) NORWALK VIRUS POLYMERASE BOUND TO 5-NITROCYTIDINE TRIPHOSPHATE AND PRIMER-TEMPLATE RNA | RNA-DEPENDENT RNA POLYMERASE, VIRAL REPLICATION, ANTIVIRAL ENZYME INHIBITOR, HELICASE, HYDROLASE, NUCLEOTIDE-BINDING, NUCLEOTIDYLTRANSFERASE, RNA REPLICATION, RNA-DIRECTED RNA POLYMERASE, TRANSFERASE, TRANSFERASE-RNA COMPLEX
3bso:A (ASP354) to (TYR416) NORWALK VIRUS POLYMERASE BOUND TO CYTIDINE 5'-TRIPHOSPHATE AND PRIMER- TEMPLATE RNA | RNA-DEPENDENT RNA POLYMERASE, VIRAL REPLICATION, ANTIVIRAL ENZYME INHIBITOR, HELICASE, HYDROLASE, NUCLEOTIDE-BINDING, NUCLEOTIDYLTRANSFERASE, RNA REPLICATION, RNA-DIRECTED RNA POLYMERASE, TRANSFERASE, TRANSFERASE-RNA COMPLEX
3bsq:A (ASN188) to (HIS238) CRYSTAL STRUCTURE OF HUMAN KALLIKREIN 7 PRODUCED AS A SECRETION PROTEIN IN E.COLI | SERINE PROTEASES, KALLIKREINS, LD6, X-RAY CRYSTAL STRUCTURE, GLYCOPROTEIN, HYDROLASE, SECRETED, ZYMOGEN
4tyd:E (VAL132) to (THR177) STRUCTURE-BASED DESIGN OF A NOVEL SERIES OF AZETIDINE INHIBITORS OF THE HEPATITIS C VIRUS NS3/4A SERINE PROTEASE | STRUCTURE-BASED DESIGN, HCV NS3/4A SERINE PROTEASE, AZETIDINE INHIBITORS, PROTEROS BIOSTRUCTURES GMBH, HYDROLASE
5gxp:A (GLN192) to (ASN245) CATIONIC TRYPSIN WITH GOL/PGE AS DIMER AT PH 4.6 | CATIONIC TRYPSIN, GOL, PGE, HYDROLASE
4u32:A (GLN192) to (VAL235) HUMAN MESOTRYPSIN COMPLEXED WITH HAI-2 KUNITZ DOMAIN 1 | SERINE PROTEASE, PROTEASE INHIBITOR, PROTEIN-PROTEIN INTERACTION, PROTEIN DEGRADATION, PROTEOLYSIS, SUBSTRATE SPECIFICITY, ENZYME KINETICS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dg4:A (GLN192) to (SER246) HUMAN MESOTRYPSIN-S39Y COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) | HUMAN MESOTRYPSIN, CANONICAL INHIBITOR, BPTI, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4e7n:A (LYS192) to (GLY244) CRYSTAL STRUCTURE OF AHV_TL-I, A GLYCOSYLATED SNAKE-VENOM THROMBIN- LIKE ENZYME FROM AGKISTRODON HALYS | BETA-BARREL, HYDROLASE, ARGININE ESTERASE, GLYCOSYLATION, EXTRACELLULAR
3pro:A (ARG140) to (TYR191) ALPHA-LYTIC PROTEASE COMPLEXED WITH C-TERMINAL TRUNCATED PRO REGION | PRO REGION, FOLDASE, PROTEIN FOLDING, SERINE PROTEASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3q76:B (PHE192) to (VAL235) STRUCTURE OF HUMAN NEUTROPHIL ELASTASE (UNCOMPLEXED) | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE
4fuj:A (GLN195) to (THR245) CRYSTAL STRUCTURE OF THE UROKINASE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1nes:E (GLN192) to (TYR234) STRUCTURE OF THE PRODUCT COMPLEX OF ACETYL-ALA-PRO-ALA WITH PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION | SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2oua:A (PRO192) to (ASN239) CRYSTAL STRUCTURE OF NOCARDIOPSIS PROTEASE (NAPASE) | SERINE PROTEASE; KINETIC STABILITY; ACID STABILITY; ELECTROSTATICS, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2oua:B (PRO192) to (ASN239) CRYSTAL STRUCTURE OF NOCARDIOPSIS PROTEASE (NAPASE) | SERINE PROTEASE; KINETIC STABILITY; ACID STABILITY; ELECTROSTATICS, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c1p:A (GLN192) to (ASN245) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c1t:A (GLN192) to (ASN245) RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES | ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c5p:A (GLN192) to (ASN245) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1- BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, HYDROLASE
1c5r:A (GLN192) to (ASN245) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1- BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, HYDROLASE
1c5u:A (GLN192) to (ASN245) STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB- MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR | SELECTIVE, S1 SITE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, UROKINASE, TRYPSIN, THROMBIN, HYDROLASE
1owj:A (GLN194) to (LEU237) SUBSTITUTED 2-NAPHTHAMIDINE INHIBITORS OF UROKINASE | PLASMINOGEN ACTIVATION, HYDROLASE, SERINE PROTEASE, GLYCOPROTEIN, KRINGLE, EGF-LIKE DOMAIN
1e36:B (GLN192) to (ASN245) PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE | HYDROLASE(SERINE PROTEASE), SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
2r2w:U (GLN192) to (THR242) UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-GPPE COMPLEX | UROKINASE, INHIBITOR, SERINE PROTEASE, EGF-LIKE DOMAIN, HYDROLASE, KRINGLE
2r9p:A (GLN192) to (SER246) HUMAN MESOTRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR(BPTI) | HUMAN MESOTRYPSIN, SERINE PROTEASE, BOVINE PANCREATIC TRYPSIN INHIBITOR, BPTI, ALTERNATIVE SPLICING, CALCIUM, DIGESTION, HYDROLASE, METAL-BINDING, SECRETED, SULFATION, ZYMOGEN, PHARMACEUTICAL, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
2r9p:C (GLN192) to (ASN245) HUMAN MESOTRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR(BPTI) | HUMAN MESOTRYPSIN, SERINE PROTEASE, BOVINE PANCREATIC TRYPSIN INHIBITOR, BPTI, ALTERNATIVE SPLICING, CALCIUM, DIGESTION, HYDROLASE, METAL-BINDING, SECRETED, SULFATION, ZYMOGEN, PHARMACEUTICAL, PROTEASE INHIBITOR, SERINE PROTEASE INHIBITOR, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1elc:A (GLN200) to (ASN255) ANALOGOUS INHIBITORS OF ELASTASE DO NOT ALWAYS BIND ANALOGOUSLY | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SERINE PROTEINASE
1gi0:A (GLN192) to (ASN245) A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE | THREE-CENTERED, VERY SHORT HYDROGEN BOND, OXYANION HOLE WATER, SHIFT OF PKA OF HIS57, STRUCTURE-BASED DRUG DESIGN, SPECIFICITY, UROKINASE, TRYPSIN, THROMBIN, ZN+2-MEDIATED INHIBITION, HYDROLASE
5a0c:A (PHE199) to (PHE243) CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE IN COMPLEX WITH A DIHYDROPYRIMIDONE INHIBITOR | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE- INHIBITOR COMPLEX
5a0c:B (PHE199) to (PHE243) CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE IN COMPLEX WITH A DIHYDROPYRIMIDONE INHIBITOR | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE- INHIBITOR COMPLEX
5a8z:A (PHE192) to (ILE242) CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE IN COMPLEX WITH A DIHYDROPYRIMIDONE INHIBITOR | TRYPSIN FAMILY FOLD, PROTEASE, HYDROLASE, HYDROLASE- INHIBITOR COMPLEX
1utp:A (GLN192) to (VAL235) TRYPSIN SPECIFICITY AS ELUCIDATED BY LIE CALCULATIONS, X-RAY STRUCTURES AND ASSOCIATION CONSTANT MEASUREMENTS | HYDROLASE, TRYPSIN, INHIBITOR SPECIFICITY, ELECTROSTATIC INTERACTIONS, COLD-ADAPTATION, MOLECULAR DYNAMICS, BINDING FREE ENERGY HYDROLASE
1v2r:T (GLN192) to (ASN245) TRYPSIN INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSRI)BT.B4 | SERINE PROTEASE, HYDROLASE, SERINE PROTEINASE
1k1o:A (GLN192) to (ASN245) BOVINE TRYPSIN-INHIBITOR COMPLEX | HYDROLASE, SERINE PROTEINASE
1y8t:A (PRO166) to (THR223) CRYSTAL STRUCTURE OF RV0983 FROM MYCOBACTERIUM TUBERCULOSIS- PROTEOLYTICALLY ACTIVE FORM | SERINE PROTEASE, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, UNKNOWN FUNCTION
1y8t:B (PRO166) to (THR223) CRYSTAL STRUCTURE OF RV0983 FROM MYCOBACTERIUM TUBERCULOSIS- PROTEOLYTICALLY ACTIVE FORM | SERINE PROTEASE, STRUCTURAL GENOMICS, PSI, PROTEIN STRUCTURE INITIATIVE, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, UNKNOWN FUNCTION
1zml:A (LYS192) to (LYS241) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF FACTOR XI IN COMPLEX WITH (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2- DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE | FXI, INHIBITOR, TRANSFERASE
3qdz:B (GLU192) to (LYS235) CRYSTAL STRUCTURE OF THE HUMAN THROMBIN MUTANT D102N IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF HUMAN PAR4. | SERINE PROTEASE, PROTEIN FUNCTION, PROTEASE-ACTIVATED RECEPTORS, HYDROLASE-HYDROLASE RECEPTOR COMPLEX
3qo6:A (PRO279) to (ARG328) CRYSTAL STRUCTURE ANALYSIS OF THE PLANT PROTEASE DEG1 | PROTEASE, HTRA, PH-SENSOR, HYDROLASE, PHOTOSYNTHESIS
3qo6:B (PRO279) to (PHE329) CRYSTAL STRUCTURE ANALYSIS OF THE PLANT PROTEASE DEG1 | PROTEASE, HTRA, PH-SENSOR, HYDROLASE, PHOTOSYNTHESIS
3qo6:C (PRO279) to (ARG328) CRYSTAL STRUCTURE ANALYSIS OF THE PLANT PROTEASE DEG1 | PROTEASE, HTRA, PH-SENSOR, HYDROLASE, PHOTOSYNTHESIS
4fue:A (GLN195) to (THR245) CRYSTAL STRUCTURE OF THE UROKINASE | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX