3e62:A (VAL1033) to (ALA1131) FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS | DRUG DISCOVERY, JAK2, FRAGMENT BASED, ATP-BINDING, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3e63:A (VAL1033) to (ALA1131) FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS | DRUG DISCOVERY, JAK2, FRAGMENT BASED, ATP-BINDING, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3e64:A (VAL1033) to (ALA1131) FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS | DRUG DISCOVERY, JAK2, FRAGMENT BASED, ATP-BINDING, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4gvj:A (ALA1081) to (TYR1176) TYK2 (JH1) IN COMPLEX WITH ADENOSINE DI-PHOSPHATE | KINASE, HYDROLASE
3efj:B (THR1261) to (THR1343) STRUCTURE OF C-MET WITH PYRIMIDONE INHIBITOR 7 | C-MET, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3efk:A (THR1261) to (PHE1344) STRUCTURE OF C-MET WITH PYRIMIDONE INHIBITOR 50 | C-MET, KINASE INHIBITOR PYRIMIDONE, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
4wo5:A (SER634) to (ALA718) CRYSTAL STRUCTURE OF A BRAF KINASE DOMAIN MONOMER | KINASE, MONOMER, INHIBITOR, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2b7a:A (VAL1033) to (ALA1131) THE STRUCTURAL BASIS OF JANUS KINASE 2 INHIBITION BY A POTENT AND SPECIFIC PAN-JANUS KINASE INHIBITOR | KINASE, TRANSFERASE
4hge:A (VAL1033) to (GLY1132) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 8 | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4hge:B (VAL1033) to (GLY1132) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 8 | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3eyg:A (ILE1060) to (LEU1153) CRYSTAL STRUCTURES OF JAK1 AND JAK2 INHIBITOR COMPLEXES | JAK KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
1byg:A (THR365) to (HIS446) KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE | PROTEIN KINASE, C-TERMINAL SRC KINASE, PHOSPHORYLATION, STAUROSPORINE, TRANSFERASE
4hvg:A (SER1005) to (GLY1101) JAK3 KINASE DOMAIN IN COMPLEX WITH 2-CYCLOPROPYL-5H-PYRROLO[2,3- B]PYRAZINE-7-CARBOXYLIC ACID ((S)-2-HYDROXY-1,2-DIMETHYL-PROPYL)- AMIDE | KINASE-INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4hvh:A (SER1005) to (SER1102) JAK3 KINASE DOMAIN IN COMPLEX WITH 2-CYCLOPROPYL-5H-PYRROLO[2,3- B]PYRAZINE-7-CARBOXYLIC ACID ((R)-2-HYDROXY-1,2-DIMETHYL-PROPYL | KINASE-INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4hvi:A (SER1005) to (GLY1101) JAK3 KINASE DOMAIN IN COMPLEX WITH 2-CYCLOPROPYL-5H-PYRROLO[2,3- B]PYRAZINE-7-CARBOXYLIC ACID ((R)-1-METHYL-2-OXO-2-PIPERIDIN-1-YL- ETHYL)-AMIDE | KINASE-INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4i5c:A (ILE1060) to (LYS1154) THE JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR | KINASE, TRANSFERASE
4i5c:B (ILE1060) to (LYS1154) THE JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR | KINASE, TRANSFERASE
4i6q:A (SER1005) to (GLY1101) JAK3 KINASE DOMAIN IN COMPLEX WITH 2-PHENOXY-5H-PYRROLO[2,3- B]PYRAZINE-7-CARBOXYLIC ACID ((S)-1-CYCLOPROPYL-ETHYL)-AMIDE | KINASE-INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1opk:A (ILE437) to (THR514) STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE | TRANSFERASE
1opl:A (ILE437) to (THR514) STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE | TRANSFERASE
3fpq:A (SER214) to (HIS288) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF WNK1 | WNK1, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTEIN KINASE INHIBITOR, SERINE/THREONINE-PROTEIN KINASE
3fpq:B (SER214) to (HIS288) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF WNK1 | WNK1, PROTEIN SERINE/THREONINE KINASE, TRANSFERASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTEIN KINASE INHIBITOR, SERINE/THREONINE-PROTEIN KINASE
3ggf:A (LYS199) to (HIS271) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE MST4 IN COMPLEX WITH AN QUINAZOLIN | SERINE/THREONINE-PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, APOPTOSIS, ATP-BINDING, GOLGI APPARATUS, KINASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE
3ggf:B (LYS199) to (HIS271) CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE MST4 IN COMPLEX WITH AN QUINAZOLIN | SERINE/THREONINE-PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, APOPTOSIS, ATP-BINDING, GOLGI APPARATUS, KINASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE
4iva:A (VAL1033) to (ASN1129) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-[(8AS)- 2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)- YL]CYCLOHEXANECARBONITRILE | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ivb:A (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-{2- [(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)- YL}CYCLOHEXANECARBONITRILE | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ivb:B (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-{2- [(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)- YL}CYCLOHEXANECARBONITRILE | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ivd:A (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 34 | PROTEIN KINASE, PHOSPHO TRANSFER, PHOSPHO TYROSINE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ivd:B (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 34 | PROTEIN KINASE, PHOSPHO TRANSFER, PHOSPHO TYROSINE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tcp:B (SER779) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC569 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE- BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3gt8:D (THR868) to (MET947) CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP | INACTIVE KINASE, DIMER, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, CELL MEMBRANE, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, ISOPEPTIDE BOND, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, UBL CONJUGATION
3tjc:A (VAL1033) to (ALA1131) CO-CRYSTAL STRUCTURE OF JAK2 WITH THIENOPYRIDINE 8 | JAK2, KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tjd:A (VAL1033) to (ALA1131) CO-CRYSTAL STRUCTURE OF JAK2 WITH THIENOPYRIDINE 19 | JAK2, KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3gvu:A (ILE464) to (SER546) THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH GLEEVEC | TYROSINE KINASE, ABL, ABELSON MURINE LEUKEMIA VIRAL ONCOGENE, ATP- BINDING, CELL ADHESION, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
4ji9:A (VAL1033) to (GLY1132) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH TG101209 | PROTEIN KINASE, PHOSPHO-TRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ji9:B (VAL1033) to (GLY1132) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH TG101209 | PROTEIN KINASE, PHOSPHO-TRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2rfn:A (THR1261) to (PHE1344) X-RAY STRUCTURE OF C-MET WITH INHIBITOR. | C-MET HGF RECEPTOR TYROSINE KINSE KINASE DOMAIN, ATP-BINDING, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO- ONCOGENE, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
2rfn:B (THR1261) to (PHE1344) X-RAY STRUCTURE OF C-MET WITH INHIBITOR. | C-MET HGF RECEPTOR TYROSINE KINSE KINASE DOMAIN, ATP-BINDING, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO- ONCOGENE, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
2dyl:A (ASP316) to (HIS393) CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 ACTIVATED MUTANT (S287D, T291D) | MKK7, KINASE, ACTIVATED MUTANT, ATP-BINDING, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, TRANSFERASE
3tv6:A (PHE635) to (LEU721) HUMAN B-RAF KINASE DOMAIN IN COMPLEX WITH A METHOXYPYRAZOLOPYRIDINYL BENZAMIDE INHIBITOR | B-RAF, KINASE, KINASE INHIBITOR, TRANSFERASE, C-RAF, RAS, MEK, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3hgk:D (LYS221) to (GLU318) CRYSTAL STRUCTURE OF EFFECT PROTEIN AVRPTOB COMPLEXED WITH KINASE PTO | FIVE HELICES, PTO P+1 LOOP, ATP-BINDING, KINASE, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, HYPERSENSITIVE RESPONSE ELICITATION, LIGASE, SECRETED, UBL CONJUGATION, UBL CONJUGATION PATHWAY, VIRULENCE, TRANSFERASE
3ugc:A (VAL1033) to (ASN1129) STRUCTURAL BASIS OF JAK2 INHIBITION BY THE TYPE II INHIBTOR NVP-BBT594 | SMALL MOLECULE INHIBITOR, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ytc:A (VAL1033) to (MET1130) DISCOVERY OF VX-509 (DECERNOTINIB): A POTENT AND SELECTIVE JANUS KINASE (JAK) 3 INHIBITOR FOR THE TREATMENT OF AUTOIMMUNE DISEASE | JANUS KINASE, KINASE, INHIBITOR, AUTOIMMUNE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ytf:A (VAL1033) to (MET1130) DISCOVERY OF VX-509 (DECERNOTINIB): A POTENT AND SELECTIVE JANUS KINASE (JAK) 3 INHIBITOR FOR THE TREATMENT OF AUTOIMMUNE DISEASES | JANUS KINASE, KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yth:A (VAL1033) to (MET1130) DISCOVERY OF VX-509 (DECERNOTINIB): A POTENT AND SELECTIVE JANUS KINASE (JAK) 3 INHIBITOR FOR THE TREATMENT OF AUTOIMMUNE DISEASES | JAK3 KINASE, JAK2 KINASE, INHIBITOR, AUTOIMMUNE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4k6z:A (ILE1060) to (LYS1154) THE JAK1 KINASE DOMAIN IN COMPLEX WITH COMPOUND 37 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4k77:A (ALA1061) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 6 | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4k77:B (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 6 | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4z16:A (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN COVALENTLY BOUND TO N-(3- (((5-CHLORO-2-((2-METHOXY-4-(4-METHYLPIPERAZIN-1-YL)PHENYL)AMINO) PYRIMIDIN-4-YL)AMINO)METHYL)PHENYL)ACRYLAMIDE | TYROSINE KINASE, KINASE DOMAIN, COVALENT INHIBITOR COMPLEX, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4z16:B (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN COVALENTLY BOUND TO N-(3- (((5-CHLORO-2-((2-METHOXY-4-(4-METHYLPIPERAZIN-1-YL)PHENYL)AMINO) PYRIMIDIN-4-YL)AMINO)METHYL)PHENYL)ACRYLAMIDE | TYROSINE KINASE, KINASE DOMAIN, COVALENT INHIBITOR COMPLEX, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4z16:C (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN COVALENTLY BOUND TO N-(3- (((5-CHLORO-2-((2-METHOXY-4-(4-METHYLPIPERAZIN-1-YL)PHENYL)AMINO) PYRIMIDIN-4-YL)AMINO)METHYL)PHENYL)ACRYLAMIDE | TYROSINE KINASE, KINASE DOMAIN, COVALENT INHIBITOR COMPLEX, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4z16:D (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN COVALENTLY BOUND TO N-(3- (((5-CHLORO-2-((2-METHOXY-4-(4-METHYLPIPERAZIN-1-YL)PHENYL)AMINO) PYRIMIDIN-4-YL)AMINO)METHYL)PHENYL)ACRYLAMIDE | TYROSINE KINASE, KINASE DOMAIN, COVALENT INHIBITOR COMPLEX, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4knb:A (THR1262) to (PHE1344) C-MET IN COMPLEX WITH OSI LIGAND | PROTEIN KINASE, TRANSFERASE
2g2h:B (ILE437) to (GLU518) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
4ksq:B (GLN635) to (SER719) CRYSTAL STRUCTURE OF HUMAN B-RAF BOUND TO A DFG-OUT INHIBITOR 5B | HUMAN SERINE/THERONINE PROTEIN KINASE, KINASE DRUG COMPLEX,, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4zim:A (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH A 9H-CARBAZOLE-1- CARBOXAMIDE INHIBITOR | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4zim:B (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH A 9H-CARBAZOLE-1- CARBOXAMIDE INHIBITOR | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2vwi:B (ASP205) to (HIS288) STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET | KINASE, STE KINASE, HYPERTENSION, TRANSFERASE
4zk5:A (ASP211) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR GNE-495 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4zk5:B (ARG213) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR GNE-495 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2w1i:A (VAL1033) to (GLY1132) STRUCTURE DETERMINATION OF AURORA KINASE IN COMPLEX WITH INHIBITOR | CHROMOSOMAL REARRANGEMENT, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE, PROTO-ONCOGENE, PHOSPHOPROTEIN, DISEASE MUTATION, SH2 DOMAIN, TRANSFERASE, ATP-BINDING, POLYMORPHISM, KINASE, CANCER, AURORA, MEMBRANE, INHIBITOR
2w1i:B (SER1032) to (GLY1132) STRUCTURE DETERMINATION OF AURORA KINASE IN COMPLEX WITH INHIBITOR | CHROMOSOMAL REARRANGEMENT, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE, PROTO-ONCOGENE, PHOSPHOPROTEIN, DISEASE MUTATION, SH2 DOMAIN, TRANSFERASE, ATP-BINDING, POLYMORPHISM, KINASE, CANCER, AURORA, MEMBRANE, INHIBITOR
4zp5:A (ASP211) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR | KINASE, INHIBITOR, TRANSFERASE-INHIBITOR COMPLEX
4zp5:B (ARG213) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR | KINASE, INHIBITOR, TRANSFERASE-INHIBITOR COMPLEX
3io7:A (VAL1033) to (MET1130) 2-AMINOPYRAZOLO[1,5-A]PYRIMIDINES AS POTENT AND SELECTIVE INHIBITORS OF JAK2 | KINASE, INHIBITOR, JAK2, JANUS KINASE, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2wd1:A (THR1261) to (THR1343) HUMAN C-MET KINASE IN COMPLEX WITH AZAINDOLE INHIBITOR | HUMAN KINASE, C-MET, AZAINDOLE, INHIBITOR, TRANSFERASE, KINASE, NUCLEOTIDE-BINDING, ATP-BINDING, TYROSINE-PROTEIN KINASE
4ll0:A (THR892) to (PRO975) EGFR L858R/T790M IN COMPLEX WITH PD168393 | KINASE, PD168393, 34-JAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ll0:B (THR892) to (PRO975) EGFR L858R/T790M IN COMPLEX WITH PD168393 | KINASE, PD168393, 34-JAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2wgj:A (THR1261) to (SER1342) X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET | C-MET, KINASE, INHIBITOR, TRANSFERASE, ATP-BINDING, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE
2wkm:A (THR1261) to (SER1342) X-RAY STRUCTURE OF PHA-00665752 BOUND TO THE KINASE DOMAIN OF C-MET | HEPATOCYTE GROWTH FACTOR RECEPTOR, C-MET, KINASE, INHIBITOR, TRANSFERASE
3w2r:A (THR892) to (ARG973) EGFR KINASE DOMAIN T790M/L858R MUTANT WITH COMPOUND 4 | ANTI-ONCOGENE, CELL CYCLE, DISEASE MUTATION, KINASE DOMAIN, RECEPTOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1iep:B (SER417) to (MET496) CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. | KINASE, KINASE INHIBITOR, STI-571, ACTIVATION LOOP, TRANSFERASE
4mh7:A (SER779) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1896 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mh7:B (SER779) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1896 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mha:A (THR778) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1817 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE- BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mha:B (SER779) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1817 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE- BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2x7f:A (ASP211) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, PHOSPHOPROTEIN, KINASE, TRANSFERASE
2x7f:B (ASP211) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, PHOSPHOPROTEIN, KINASE, TRANSFERASE
2x7f:C (LYS213) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, PHOSPHOPROTEIN, KINASE, TRANSFERASE
2x7f:D (ASP211) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITOR | SERINE/THREONINE-PROTEIN KINASE, PHOSPHOPROTEIN, KINASE, TRANSFERASE
2itw:A (THR892) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AFN941 | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, AFN941, EGFR, KINASE, STAUROSPORINE, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
2xa4:A (VAL1033) to (MET1130) INHIBITORS OF JAK2 KINASE DOMAIN | KINASE, MEMBRANE, TRANSFERASE, ATP-BINDING, PROTO-ONCOGENE, PHOSPHOPROTEIN
2xa4:B (VAL1033) to (ALA1131) INHIBITORS OF JAK2 KINASE DOMAIN | KINASE, MEMBRANE, TRANSFERASE, ATP-BINDING, PROTO-ONCOGENE, PHOSPHOPROTEIN
5ap3:A (LYS714) to (HIS788) NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. | TRANSFERASE, MPS1, PROTEIN KINASE, MITOSIS, DRUG RESISTANCE
5ap2:A (LYS714) to (HIS788) NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. | TRANSFERASE, MPS1, PROTEIN KINASE, MITOSIS, DRUG RESISTANCE
5ap4:A (LYS714) to (HIS788) NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. | TRANSFERASE, MPS1, PROTEIN KINASE, MITOSIS, DRUG RESISTANCE
5ap5:A (SER712) to (HIS788) NATURALLY OCCURRING MUTATIONS IN THE MPS1 GENE PREDISPOSE CELLS TO KINASE INHIBITOR DRUG RESISTANCE. | TRANSFERASE, MPS1, PROTEIN KINASE, MITOSIS, DRUG RESISTANCE
3zc5:A (THR1261) to (THR1343) X-RAY STRUCTURE OF C-MET KINASE IN COMPLEX WITH INHIBITOR ( S)-6-(1-(6-(1-METHYL-1H-PYRAZOL-4-YL)-(1,2,4)TRIAZOLO(4,3- B)PYRIDAZIN-3-YL)ETHYL)QUINOLINE. | TRANSFERASE, KINASE, INHIBITOR
3zc6:A (SER1005) to (LEU1098) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH AN INDAZOLE SUBSTITUTED PYRROLOPYRAZINE INHIBITOR | TRANSFERASE, SCID, SEVERE COMBINED IMMUNODEFICIENCY, STAT5, STAT6, INTERLEUKIN-2, COMMON-GAMMA CHAIN, ATP SITE KINASE INHIBITOR, CANCER
3zc6:B (SER1005) to (LEU1098) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH AN INDAZOLE SUBSTITUTED PYRROLOPYRAZINE INHIBITOR | TRANSFERASE, SCID, SEVERE COMBINED IMMUNODEFICIENCY, STAT5, STAT6, INTERLEUKIN-2, COMMON-GAMMA CHAIN, ATP SITE KINASE INHIBITOR, CANCER
3zc6:C (SER1005) to (LEU1098) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH AN INDAZOLE SUBSTITUTED PYRROLOPYRAZINE INHIBITOR | TRANSFERASE, SCID, SEVERE COMBINED IMMUNODEFICIENCY, STAT5, STAT6, INTERLEUKIN-2, COMMON-GAMMA CHAIN, ATP SITE KINASE INHIBITOR, CANCER
3zc6:D (SER1005) to (LEU1098) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH AN INDAZOLE SUBSTITUTED PYRROLOPYRAZINE INHIBITOR | TRANSFERASE, SCID, SEVERE COMBINED IMMUNODEFICIENCY, STAT5, STAT6, INTERLEUKIN-2, COMMON-GAMMA CHAIN, ATP SITE KINASE INHIBITOR, CANCER
3zcl:A (THR1261) to (SER1342) X-RAY STRUCTURE OF C-MET KINASE IN COMPLEX WITH INHIBITOR ( S)-3-(1-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)ETHYL)-N-ISOPROPYL-( 1,2,4)TRIAZOLO(4,3-B)PYRIDAZIN-6-AMINE | TRANSFERASE, INHIBITOR
1k9a:F (THR365) to (GLU447) CRYSTAL STRUCTURE ANALYSIS OF FULL-LENGTH CARBOXYL-TERMINAL SRC KINASE AT 2.5 A RESOLUTION | CARBOXYL-TERMINAL SRC KINASE, COOH-TERMINAL SRC KINASE, CSK, SRC, SFK, SIGNAL TRANSDUCTION, SH2, SH3, SRC HOMOLOGY, TYROSINE KINASE, CYTOPLASMIC TYROSINE KINASE, CBP, ONCOGENE, CANCER, TRANSFERASE
3zmm:A (VAL1033) to (MET1130) INHIBITORS OF JAK2 KINASE DOMAIN | TRANSFERASE
3zmm:B (SER1032) to (ALA1131) INHIBITORS OF JAK2 KINASE DOMAIN | TRANSFERASE
3zze:A (THR1261) to (THR1343) CRYSTAL STRUCTURE OF C-MET KINASE DOMAIN IN COMPLEX WITH N'- ((3Z)-4-CHLORO-7-METHYL-2-OXO-1,2-DIHYDRO-3H-INDOL-3- YLIDENE)-2-(4-HYDROXYPHENYL)PROPANOHYDRAZIDE | TRANSFERASE, INHIBITOR
5cf4:A (SER1032) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10- TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf4:B (VAL1033) to (GLY1132) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10- TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf5:A (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 7-[(DIMETHYL-1,3-THIAZOL-2-YL)AMINO]-10-ETHYL-3-METHYL-3,5,8,10- TETRAAZATRICYCLO[7.3.0.02,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf5:B (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 7-[(DIMETHYL-1,3-THIAZOL-2-YL)AMINO]-10-ETHYL-3-METHYL-3,5,8,10- TETRAAZATRICYCLO[7.3.0.02,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf6:A (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(METHYLAMINO)-3,5,8,10- TETRAAZATRICYCLO [7.3.0.02,6]DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf6:B (VAL1033) to (MET1130) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(METHYLAMINO)-3,5,8,10- TETRAAZATRICYCLO [7.3.0.02,6]DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf8:A (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10- TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5cf8:B (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL- 10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10- TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11- CARBOXAMIDE | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3jy9:A (VAL1033) to (MET1130) JANUS KINASE 2 INHIBITORS | KINASE, INHIBITOR, JAK2, JANUS KINASE, ATP-BINDING, DISEASE MUTATION, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4obo:A (ARG213) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 22), 6-(3-CHLOROPHENYL) QUINAZOLIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4obo:B (ARG213) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 22), 6-(3-CHLOROPHENYL) QUINAZOLIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4obq:A (ASP211) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 31), N-[3-(4- AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4obq:B (ASP215) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 31), N-[3-(4- AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4oli:A (SER792) to (GLN870) THE PSEUDOKINASE/KINASE PROTEIN FROM JAK-FAMILY MEMBER TYK2 | PROTEIN KINASE, PHOSPHO-TRANSFER, TRANSFERASE
4oli:A (ALA1081) to (TYR1176) THE PSEUDOKINASE/KINASE PROTEIN FROM JAK-FAMILY MEMBER TYK2 | PROTEIN KINASE, PHOSPHO-TRANSFER, TRANSFERASE
3kck:A (VAL1033) to (MET1130) A NOVEL CHEMOTYPE OF KINASE INHIBITORS | KINASE, INHIBITOR, JAK2, JANUS KINASE, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
5cyz:A (SER191) to (PHE273) STRUCTURE OF S. CEREVISIAE HRR25:MAM1 COMPLEX, FORM 1 | CASEIN KINASE, MONOPOLIN, TRANSFERASE
4p7e:A (VAL1033) to (ALA1131) TRIAZOLOPYRIDINE COMPOUNDS AS SELECTIVE JAK1 INHIBITORS: FROM HIT IDENTIFICATION TO GLPG0634 | TRANSFERASE, JAK1 INHIBITOR, TRIAZOLOPYRIDINE
4p7e:B (VAL1033) to (ALA1131) TRIAZOLOPYRIDINE COMPOUNDS AS SELECTIVE JAK1 INHIBITORS: FROM HIT IDENTIFICATION TO GLPG0634 | TRANSFERASE, JAK1 INHIBITOR, TRIAZOLOPYRIDINE
1mrv:A (VAL331) to (HIS406) CRYSTAL STRUCTURE OF AN INACTIVE AKT2 KINASE DOMAIN | AGC SERINE THREONINE KINASE, AKT PKB KINASE DOMAIN, TUMORIGENESIS, X-RAY CRYSTAL STRUCTURE, SIGNAL TRANSDUCTION, TRANSFERASE
1mry:A (ALA330) to (HIS406) CRYSTAL STRUCTURE OF AN INACTIVE AKT2 KINASE DOMAIN | AGC SERINE THREONINE KINASE, AKT PKB KINASE DOMAIN, TUMORIGENESIS, X-RAY CRYSTAL STRUCTURE, SIGNAL TRANSDUCTION, TRANSFERASE
5dg5:B (THR1261) to (PHE1344) CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP- 4157 | TYROSINE KINASE DOMAIN, HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET, C- MET, ALTIRATINIB ANALOG, DP-4157, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5di1:A (ASP215) to (HIS286) MAP4K4 IN COMPLEX WITH AN INHIBITOR | KINASE, INHIBITOR, COMPLEX, MEDICINAL CHEMISTRY, TRANSFERASE- INHIBITOR COMPLEX
5di1:B (SER214) to (HIS286) MAP4K4 IN COMPLEX WITH AN INHIBITOR | KINASE, INHIBITOR, COMPLEX, MEDICINAL CHEMISTRY, TRANSFERASE- INHIBITOR COMPLEX
1yvj:A (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN IN COMPLEX WITH A STAUROSPORINE ANALOGUE | TYROSINE KINASE; SCID; SEVERE COMBINED IMMUNODEFICIENCY; STAT5; STAT6; INTERLEUKIN-2; COMMON-GAMMA CHAIN, TRANSFERASE
5drb:A (SER402) to (HIS476) CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH WNK463 | KINASE, INHIBITOR, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4aoi:A (THR1261) to (THR1343) CRYSTAL STRUCTURE OF C-MET KINASE DOMAIN IN COMPLEX WITH 4-( 3-((1H- PYRROLO(2,3-B)PYRIDIN-3-YL)METHYL)-(1,2,4)TRIAZOLO( 4,3-B)(1,2,4) TRIAZIN-6-YL)BENZONITRILE | TRANSFERASE, KINASE INHIBITOR
4ap7:A (THR1261) to (THR1343) CRYSTAL STRUCTURE OF C-MET KINASE DOMAIN IN COMPLEX WITH 4-( (6-(4- FLUOROPHENYL)-(1,2,4)TRIAZOLO(4,3-B)(1,2,4)TRIAZIN-3-YL)METHYL) PHENOL | TRANSFERASE
4py1:A (TYR1080) to (TYR1176) CRYSTAL STRUCTURE OF TYK2 IN COMPLEX WITH COMPOUND 15, 6-((2,5- DIMETHOXYPHENYL)THIO)-3-(1-METHYL-1H-PYRAZOL-4-YL)-[1,2,4]TRIAZOLO[4, 3-B]PYRIDAZINE | KINASE, TRANSFERASE
4q2a:A (SER402) to (HIS476) WNK1: A CHLORIDE SENSOR VIA AUTOPHOSPHORYLATION | PROTEIN SERINE/THREONINE KINASE, KINASE, ATP-BINDING, UNPHOSPHORYLATED, TRANSFERASE
3lpb:A (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JAK2 COMPLEXED WITH A POTENT 2,8-DIARYL- QUINOXALINE INHIBITOR | SMALL MOLECULE INHIBITOR, ATP SITE KINASE INHIBITOR, NOVARTIS PRODUCT NVP-BLU040, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3lpb:B (VAL1033) to (ALA1131) CRYSTAL STRUCTURE OF JAK2 COMPLEXED WITH A POTENT 2,8-DIARYL- QUINOXALINE INHIBITOR | SMALL MOLECULE INHIBITOR, ATP SITE KINASE INHIBITOR, NOVARTIS PRODUCT NVP-BLU040, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
5e1e:A (ILE1060) to (LEU1153) HUMAN JAK1 KINASE IN COMPLEX WITH COMPOUND 30 AT 2.30 ANGSTROMS RESOLUTION | KINASE, TRANSFERASE
5e1e:B (ILE1060) to (LEU1153) HUMAN JAK1 KINASE IN COMPLEX WITH COMPOUND 30 AT 2.30 ANGSTROMS RESOLUTION | KINASE, TRANSFERASE
3lxl:A (SER1005) to (LEU1098) STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6 | TYK2, JAK3, INFLAMMATION, CANCER, PAN INHIBITOR, ATP-BINDING, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SCID, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3lxn:A (TYR1080) to (TYR1176) STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6 | TYK2, JAK3, INFLAMMATION, CANCER, PAN INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3lxp:A (ALA1081) to (GLY1178) STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6 | TYK2, JAK3, INFLAMMATION, CANCER, PAN INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
5ei2:A (PRO713) to (HIS788) RAPID DISCOVERY OF PYRIDO[3,4-D]PYRIMIDINE INHIBITORS OF MONOPOLAR SPINDLE KINASE 1 (MPS1) USING A STRUCTURE-BASED HYDRIDIZATION APPROACH | SPINDLE ASSEMBLY CHECKPOINT (SAC), ONCOLOGY TARGET PYRIDO[3, 4- D]PYRIMIDINE BASED INHIBITORS SELECTIVE AGAINST MPS1, TRANSFERASE
4bbe:A (VAL1033) to (ASP1128) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4bbe:B (VAL1033) to (ASP1128) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4bbe:C (VAL1033) to (ASP1128) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4bbe:D (VAL1033) to (ASP1128) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4qps:A (SER1005) to (TRP1099) CRYSTAL STRUCTURE OF JAK3 COMPLEXED TO N-[3-(6-PHENYLAMINO-PYRAZIN-2- YL)-3H-BENZOIMIDAZOL-5-YL]-ACRYLAMIDE | KINASE CATALYTIC DOMAIN, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qps:C (SER1005) to (SER1102) CRYSTAL STRUCTURE OF JAK3 COMPLEXED TO N-[3-(6-PHENYLAMINO-PYRAZIN-2- YL)-3H-BENZOIMIDAZOL-5-YL]-ACRYLAMIDE | KINASE CATALYTIC DOMAIN, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5eob:A (THR1261) to (THR1343) CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH NOVEL INHIBITOR | CMET INHIBITOR, TRANSFERASE
4bhz:A (LYS714) to (HIS788) SCAFFOLD FOCUSED VIRTUAL SCREENING: PROSPECTIVE APPLICATION TO THE DISCOVERY OF TTK INHIBITOR | TRANSFERASE, MITOSIS
4qt1:A (ARG1006) to (SER1102) JAK3 KINASE DOMAIN IN COMPLEX WITH 1-[(3S)-1-ISOBUTYLSULFONYL-3- PIPERIDYL]-3-(5H-PYRROLO[2,3-B]PYRAZIN-2-YL)UREA | KINASE-INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5f1z:A (ALA1081) to (TYR1176) STRUCTURE OF TYK2 WITH INHIBITOR 16: 3-AZANYL-5-[(2~{S})-3- METHYLBUTAN-2-YL]-7-[1-METHYL-5-(2-OXIDANYLPROPAN-2-YL)PYRAZOL-3-YL]- 1~{H}-PYRAZOLO[4,3-C]PYRIDIN-4-ONE | KINASE, COMPLEX, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5f20:A (ALA1081) to (TYR1176) STRUCTURE OF TYK2 WITH INHIBITOR 4: 3-AZANYL-5-(2-METHYLPHENYL)-7-(1- METHYLPYRAZOL-3-YL)-1~{H}-PYRAZOLO[4,3-C]PYRIDIN-4-ONE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3brb:B (SER779) to (LEU861) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE- PROTEIN KINASE MER IN COMPLEX WITH ADP | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, IMMUNOGLOBULIN DOMAIN, MEMBRANE, PHOSPHOPROTEIN, TRANSMEMBRANE
4r1y:A (THR1261) to (THR1343) IDENTIFICATION AND OPTIMIZATION OF PYRIDAZINONES AS POTENT AND SELECTIVE C-MET KINASE INHIBITOR | TRANSFERASE INHIBITOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4c4f:A (LYS714) to (HIS788) STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1 | TRANSFERASE, PROTEIN KINASE, MITOSIS, STRUCTURE-BASED DESIGN
4c4j:A (LYS714) to (HIS788) STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1 | TRANSFERASE, MITOSIS, STRUCTURE-BASED DRUG DESIGN
4c61:A (VAL1033) to (MET1130) INHIBITORS OF JAK2 KINASE DOMAIN | KINASE, TRANSFERASE
4c61:B (VAL1033) to (ALA1131) INHIBITORS OF JAK2 KINASE DOMAIN | KINASE, TRANSFERASE
4c62:A (VAL1033) to (MET1130) INHIBITORS OF JAK2 KINASE DOMAIN | TRANSFERASE
4c62:B (VAL1033) to (ALA1131) INHIBITORS OF JAK2 KINASE DOMAIN | TRANSFERASE
3nyx:A (ALA1081) to (TYR1176) NON-PHOSPHORYLATED TYK2 JH1 DOMAIN WITH QUINOLINE-THIADIAZOLE- THIOPHENE INHIBITOR | PROTEIN KINASE, TYROSINE PHOSPHORYLATION, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3nz0:A (ALA1081) to (TYR1176) NON-PHOSPHORYLATED TYK2 KINASE WITH CMP6 | PROTEIN KINASE, TYROSINE PHOSPHORYLATION, TRANSFERASE
4rzv:B (SER634) to (SER722) CRYSTAL STRUCTURE OF THE BRAF (R509H) KINASE DOMAIN MONOMER BOUND TO VEMURAFENIB | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3d7t:A (THR365) to (GLU447) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK SRC TYROSINE KINASE, ATP-BINDING, CYTOPLASM, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, PROTO- ONCOGENE
4cv8:A (LYS714) to (HIS788) MPS1 KINASE WITH 3-AMINOPYRIDIN-2-ONE INHIBITORS | TRANSFERASE, INHIBITOR
4cva:A (LYS714) to (HIS788) MPS1 KINASE WITH 3-AMINOPYRIDIN-2-ONE INHIBITORS | TRANSFERASE, FRAGMENT, INHIBITOR
3dak:A (ASP205) to (HIS288) CRYSTAL STRUCTURE OF DOMAIN-SWAPPED OSR1 KINASE DOMAIN | SERINE/THREONINE PROTEIN KINASE, STE20, DOMAIN-SWAPPING, ATP-BINDING, KINASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE
3dbq:A (PRO713) to (HIS788) CRYSTAL STRUCTURE OF TTK KINASE DOMAIN | MPS1 STRUCTURE, KINASE ACTIVATION, PHOSPHORYLATION, ATP- BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, TYROSINE-PROTEIN KINASE
4d0w:A (VAL1033) to (MET1130) PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS | TRANSFERASE, DRUG DISCOVERY, PROTEIN KINASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, POLYCYTHEMIA VERA, TUMOUR CELL PROLIFERATION INHIBITION, ANTI-CANCER AGENTS
4u3z:B (SER214) to (HIS286) APO MAP4K4 T181E PHOSPHOMIMETIC MUTANT | KINASE, TRANSFERASE
4u40:A (TYR212) to (HIS286) MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (MAP4K4) BOUND TO AMPPNP | KINASE, TRANSFERASE
4u40:B (ARG213) to (HIS286) MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (MAP4K4) BOUND TO AMPPNP | KINASE, TRANSFERASE
4u41:A (ASP211) to (HIS286) MAP4K4 BOUND TO INHIBITOR COMPOUND 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u41:B (ARG213) to (HIS286) MAP4K4 BOUND TO INHIBITOR COMPOUND 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u43:A (ASP215) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 6) | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u44:A (ASP211) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 16) | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u44:B (ASP215) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 16) | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u45:A (ASP211) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 25) | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u45:B (ARG213) to (HIS286) MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 25) | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5he1:A (SER370) to (SER450) HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG224062 | RGS, KINASE, PH, WD-40, INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hx8:A (ILE1060) to (LYS1154) JAK1 COMPLEX WITH 4-[(4-AMINOCYCLOHEXYL)AMINO]-3-(1H-BENZIMIDAZOL-2- YL)-1H-PYRIDIN-2-ONE | KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hx8:B (ILE1060) to (LYS1154) JAK1 COMPLEX WITH 4-[(4-AMINOCYCLOHEXYL)AMINO]-3-(1H-BENZIMIDAZOL-2- YL)-1H-PYRIDIN-2-ONE | KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pjc:A (SER1005) to (SER1100) CRYSTAL STRUCTURE OF JAK3 COMPLEXED WITH A POTENT ATP SITE INHIBITOR SHOWING HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY | SMALL MOLECULE INHIBITOR, ATP SITE KINASE INHIBITOR, ATP-BINDING, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e1z:A (TYR1076) to (GLN1173) STRUCTURE OF MOUSE TYK-2 COMPLEXED TO A 3-AMINOINDAZOLE INHIBITOR | KINASE CATALYTIC DOMAIN, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e20:A (TYR1076) to (TYR1172) STRUCTURE OF MOUSE TYK-2 COMPLEXED TO A 3-AMINOINDAZOLE INHIBITOR | KINASE CATALYTIC DOMAIN, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ppk:A (PHE635) to (LEU721) HUMAN B-RAF KINASE IN COMPLEX WITH A NON-OXIME FUROPYRIDINE INHIBITOR | PROTEIN KINASE, B-RAF ATP-COMPETITIVE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4e4l:A (ILE1060) to (GLY1148) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4l:B (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4l:E (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4l:D (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4m:A (VAL1033) to (MET1130) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4m:B (VAL1033) to (ASN1129) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4m:D (SER1032) to (MET1130) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4m:E (VAL1033) to (ASN1129) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 30 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4n:A (ALA1061) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 49 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e4n:B (ALA1061) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 49 | O-PHOSPHOTYROSINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e5w:A (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 26 | JAK1, KINASE DOMAIN, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e5w:B (ILE1060) to (LEU1153) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 26 | JAK1, KINASE DOMAIN, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pri:A (PHE635) to (LEU721) CRYSTAL STRUCTURE OF HUMAN B-RAF KINASE IN COMPLEX WITH A NON-OXIME FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pri:B (PHE635) to (LEU721) CRYSTAL STRUCTURE OF HUMAN B-RAF KINASE IN COMPLEX WITH A NON-OXIME FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ehg:A (PHE635) to (LEU721) B-RAF KINASE DOMAIN IN COMPLEX WITH AN AMINOPYRIDIMINE-BASED INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ehg:B (PHE635) to (LEU721) B-RAF KINASE DOMAIN IN COMPLEX WITH AN AMINOPYRIDIMINE-BASED INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ehz:A (ILE1060) to (LYS1154) THE JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ehz:B (ILE1060) to (LEU1153) THE JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ehz:C (ILE1060) to (LEU1153) THE JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ehz:D (ILE1060) to (LYS1154) THE JAK1 KINASE DOMAIN IN COMPLEX WITH INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ei4:A (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 20 | PROTEIN KINASE, PHOSPHO-TRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ei4:B (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 20 | PROTEIN KINASE, PHOSPHO-TRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pyy:B (ILE437) to (LEU529) DISCOVERY AND CHARACTERIZATION OF A CELL-PERMEABLE, SMALL-MOLECULE C- ABL KINASE ACTIVATOR THAT BINDS TO THE MYRISTOYL BINDING SITE | TYROSINE KINASE, TRANSFERASE
3q32:A (VAL1033) to (ALA1131) STRUCTURE OF JANUS KINASE 2 WITH A PYRROLOTRIAZINE INHIBITOR | ATP-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q32:B (VAL1033) to (ALA1131) STRUCTURE OF JANUS KINASE 2 WITH A PYRROLOTRIAZINE INHIBITOR | ATP-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q6w:A (THR1262) to (THR1343) STRUCTURE OF DUALLY-PHOSPHORYLATED MET RECEPTOR KINASE IN COMPLEX WITH AN MK-2461 ANALOG WITH SPECIFICITY FOR THE ACTIVATED RECEPTOR | TYROSINE KINASE, TWO PHOSPHOTYROSINE RESIUDES, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4f08:A (VAL1033) to (ALA1131) DISCOVERY AND OPTIMIZATION OF C-2 METHYL IMIDAZO-PYRROLOPYRIDINES AS POTENT AND ORALLY BIOAVAILABLE JAK1 INHIBITORS WITH SELECTIVITY OVER JAK2 | JAK2, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4f08:B (VAL1033) to (ALA1131) DISCOVERY AND OPTIMIZATION OF C-2 METHYL IMIDAZO-PYRROLOPYRIDINES AS POTENT AND ORALLY BIOAVAILABLE JAK1 INHIBITORS WITH SELECTIVITY OVER JAK2 | JAK2, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4f09:A (VAL1033) to (MET1130) DISCOVERY AND OPTIMIZATION OF C-2 METHYL IMIDAZO-PYRROLOPYRIDINES AS POTENT AND ORALLY BIOAVAILABLE JAK1 INHIBITORS WITH SELECTIVITY OVER JAK2 | JAK2, KINASE DOMAIN, JH1 DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5j5t:A (ASN192) to (HIS270) GLK CO-CRYSTAL STRUCTURE WITH AMINOPYRROLOPYRIMIDINE INHIBITOR | PROTEIN KINSAE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4v0g:B (SER1005) to (LEU1098) JAK3 IN COMPLEX WITH A COVALENT EGFR INHIBITOR | TRANSFERASE, EGFR MUTANT, T790M
3qrk:A (ILE418) to (MET496) THE CRYSTAL STRUCTURE OF HUMAN ABL1 KINASE DOMAIN IN COMPLEX WITH DP- 987 | ABL1, KINASE, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fk6:A (ALA1061) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 72 | PROTEIN KINASE, PHOSPHO TRANSFER, PHOSPHO TYROSINE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3rcd:C (THR900) to (PRO983) HER2 KINASE DOMAIN COMPLEXED WITH TAK-285 | KINASE DOMAIN, RECEPTOR, TRANSFERASE, TYROSINE-PROTEIN KINASE, TYROSINE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, ANTI-ONCOGENE, CELL CYCLE, DISEASE, MUTATION, ATP-BINDING, NUCLEOTIDE-BINDING, GLYCOPROTEIN, PHOSPHOPROTEIN, MEMBRANE, SECRETED
5jsm:A (SER634) to (LEU721) BRAFV600E KINASE DOMAIN IN COMPLEX WITH CHEMICALLY LINKED VEMURAFENIB INHIBITOR VEM-3-VEM | KINASE, DIMER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fzf:B (ASP201) to (HIS271) CRYSTAL STRUCTURE OF MST4-MO25 COMPLEX WITH DKI | SCAFFOLD PROTEIN, PROTEIN SER/THR KINASE, ATP BINDING, SIGNALING PROTEIN-TRANSFERASE-INHIBITOR COMPLEX
4g9r:B (PHE635) to (LEU721) B-RAF V600E KINASE DOMAIN BOUND TO A TYPE II DIHYDROQUINAZOLINE INHIBITOR | INHIBITOR, TYPE II, TRANSFERASE, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gfo:A (TYR1080) to (TYR1176) TYK2 KINASE (JH1 DOMAIN) WITH 2,6-DICHLORO-N-(2-OXO-2,5- DIHYDROPYRIDIN-4-YL)BENZAMIDE | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gih:A (ALA1081) to (TYR1176) TYK2 (JH1) IN COMPLEX WITH 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL) AMINO]PYRIDIN-4-YL}BENZAMIDE | TYROSINE KINASE, KINASE, ATP BINDING, INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4gii:A (ALA1081) to (TYR1176) TYK2 (JH1) IN COMPLEX WITH 2,6-DICHLORO-4-CYANO-N-{2- [(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE | AMINOPYRIDINE, BENZAMIDE, KINASE, ENZYME INHIBITOR, TYROSINE KINASE, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gj2:A (TYR1080) to (TYR1176) TYK2 (JH1) IN COMPLEX WITH 2,6-DICHLORO-N-[2-({[(1R,2R)-2- FLUOROCYCLOPROPYL]CARBONYL}AMINO)PYRIDIN-4-YL]BENZAMIDE | KINASE, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gl9:D (VAL1033) to (ILE1130) CRYSTAL STRUCTURE OF INHIBITORY PROTEIN SOCS3 IN COMPLEX WITH JAK2 KINASE DOMAIN AND FRAGMENT OF GP130 INTRACELLULAR DOMAIN | KINASE INHIBITOR RECEPTOR CYTOKINE SIGNALLING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gmy:A (VAL1033) to (ASN1129) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH 2,6-DICHLORO-N-{2- [(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE | JAK2, JH1 KINASE DOMAIN, TYROSINE KINASE, PHOSPHOTRANSFERASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5l3a:A (VAL1033) to (ASN1129) FRAGMENT-BASED DISCOVERY OF 6-ARYLINDAZOLE JAK INHIBITORS | DOUBLE F MUTANT, TRANSFERASE
5lwm:A (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF JAK3 IN COMPLEX WITH COMPOUND 4 (FM381) | TRANSFERASE, KINASE, JAK3, COVALENT INHIBITOR, REVERSIBLE COVALENT INHIBITOR, INDUCED POCKET, ARGININE POCKET, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
5tf9:A (SER402) to (HIS476) CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH MN2+AMPPNP AND WNK476 | SERINE-THREONINE-PROTEIN KINASE, INHIBITOR, TERNARY, COMPLEX, ALLOSTERIC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5tf9:B (SER402) to (HIS476) CRYSTAL STRUCTURE OF WNK1 IN COMPLEX WITH MN2+AMPPNP AND WNK476 | SERINE-THREONINE-PROTEIN KINASE, INHIBITOR, TERNARY, COMPLEX, ALLOSTERIC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5toz:A (SER1005) to (LEU1098) JAK3 WITH COVALENT INHIBITOR PF-06651600 | JAK3 COVALENT KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rvg:A (SER1032) to (MET1130) CRYSTALS STRUCTURE OF JAK2 WITH A 1-AMINO-5H-PYRIDO[4,3-B]INDOL-4- CARBOXAMIDE INHIBITOR | TYROSINE KINASE, JANUS KINASE 2, ENZYME INHIBITORS, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2p0c:A (SER779) to (LEU861) CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
3eyh:A (ILE1060) to (LEU1153) CRYSTAL STRUCTURES OF JAK1 AND JAK2 INHIBITOR COMPLEXES | JAK KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3fup:A (VAL1033) to (ALA1131) CRYSTAL STRUCTURES OF JAK1 AND JAK2 INHIBITOR COMPLEXES | KINASE, PTK DOMAIN, PROTEIN-INHIBITOR COMPLEX, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3fup:B (VAL1033) to (MET1130) CRYSTAL STRUCTURES OF JAK1 AND JAK2 INHIBITOR COMPLEXES | KINASE, PTK DOMAIN, PROTEIN-INHIBITOR COMPLEX, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO- ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4ivc:A (ALA1061) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR (TRANS-4-{2- [(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)- YL}CYCLOHEXYL)ACETONITRILE | PROTEIN KINASE, PHOSPHO TRANSFER, PHOSPHO TYROSINE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ivc:B (ILE1060) to (LYS1154) JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR (TRANS-4-{2- [(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)- YL}CYCLOHEXYL)ACETONITRILE | PROTEIN KINASE, PHOSPHO TRANSFER, PHOSPHO TYROSINE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4jia:A (VAL1033) to (ASN1129) JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 9 | PROTEIN KINASE, PHOSPHOTRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yti:A (VAL1033) to (MET1130) DISCOVERY OF VX-509 (DECERNOTINIB): A POTENT AND SELECTIVE JANUS KINASE (JAK) 3 INHIBITOR FOR THE TREATMENT OF AUTOIMMUNE DISEASE | JANUS KINASE, JAK2, JAK3, KINASE, INHIBITOR, AUTOIMMUNE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2g2f:B (ILE418) to (SER500) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
3iok:A (VAL1033) to (MET1130) 2-AMINOPYRAZOLO[1,5-A]PYRIMIDINES AS POTENT AND SELECTIVE INHIBITORS OF JAK2 | KINASE, INHIBITOR, JAK2, JANUS KINASE, ATP-BINDING, DISEASE MUTATION, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
5aep:A (VAL1033) to (MET1130) NOVEL PYRROLE CARBOXAMIDE INHIBITORS OF JAK2 AS POTENTIAL TREATMENT OF MYELOPROLIFERATIVE DISORDERS | TRANSFERASE, PROTEIN KINASE, JAK2, MYELOPROLIFERATIVE DISORDERS, TUMOUR CELL PROLIFERATION INHIBITION, ANTI-CANCER AGENTS
5ax9:A (ASP211) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2 AND NCK- INTERACTING PROTEIN KINASE IN COMPLEX WITH COMPUND 9 | INHIBITOR, KINASE, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5ax9:C (LYS213) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2 AND NCK- INTERACTING PROTEIN KINASE IN COMPLEX WITH COMPUND 9 | INHIBITOR, KINASE, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3wyy:A (LYS714) to (HIS788) CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH (E)- 3-(4-((6-(((3S,5S,7S)-ADAMANTAN-1-YL)AMINO)-4-AMINO-5-CYANOPYRIDIN-2- YL)AMINO)-2-(CYANOMETHOXY)PHENYL)-N-(2-METHOXYETHYL)ACRYLAMIDE | KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, INHIBITOR COMPLEX, ATP BINDING
3zep:A (SER1005) to (LEU1098) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRAZINE-2-PHENYL ETHER INHIBITOR | TRANSFERASE, STAT5, STAT6, INTERLEUKIN-2, COMMON-GAMMA CHAIN, ATP SITE KINASE INHIBITOR, CANCER, SCID, SEVERE COMBINED IMMUNODEFICIENCY
3zep:D (SER1005) to (TRP1099) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRAZINE-2-PHENYL ETHER INHIBITOR | TRANSFERASE, STAT5, STAT6, INTERLEUKIN-2, COMMON-GAMMA CHAIN, ATP SITE KINASE INHIBITOR, CANCER, SCID, SEVERE COMBINED IMMUNODEFICIENCY
5cwz:B (LYS213) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2 AND NCK- INTERACTING PROTEIN KINASE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5d7a:A (LYS213) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF TRAF2 AND NCK-INTERACTING PROTEIN KINASE WITH NCB-0846 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5d7a:C (ASP211) to (HIS286) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF TRAF2 AND NCK-INTERACTING PROTEIN KINASE WITH NCB-0846 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4aqc:A (VAL1033) to (ALA1131) TRIAZOLOPYRIDINE-BASED INHIBITOR OF JANUS KINASE 2 | TRANSFERASE, ATP-BINDING
4aqc:B (VAL1033) to (GLY1132) TRIAZOLOPYRIDINE-BASED INHIBITOR OF JANUS KINASE 2 | TRANSFERASE, ATP-BINDING
3lxk:A (SER1005) to (LEU1098) STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6 | TYK2, JAK3, INFLAMMATION, CANCER, PAN INHIBITOR, ATP-BINDING, DISEASE MUTATION, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SCID, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
5ehl:A (SER712) to (HIS788) RAPID DISCOVERY OF PYRIDO[3,4-D]PYRIMIDINE INHIBITORS OF MONOPOLAR SPINDLE KINASE 1 (MPS1) USING A STRUCTURE-BASED HYDRIDIZATION APPROACH | SPINDLE ASSEMBLY CHECKPOINT (SAC), ONCOLOGY TARGET PYRIDO[3, 4- D]PYRIMIDINE BASED INHIBITORS SELECTIVE AGAINST MPS1, TRANSFERASE
5ei8:A (SER712) to (HIS788) RAPID DISCOVERY OF PYRIDO[3,4-D]PYRIMIDINE INHIBITORS OF MONOPOLAR SPINDLE KINASE 1 (MPS1) USING A STRUCTURE-BASED HYDRIDIZATION APPROACH | SPINDLE ASSEMBLY CHECKPOINT (SAC), ONCOLOGY TARGET PYRIDO[3, 4- D]PYRIMIDINE BASED INHIBITORS SELECTIVE AGAINST MPS1, TRANSFERASE
4bbf:A (VAL1033) to (ASP1128) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4bbf:B (VAL1033) to (ARG1127) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4bbf:C (VAL1033) to (ARG1127) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4bbf:D (VAL1033) to (ASP1128) AMINOALKYLPYRIMIDINE INHIBITOR COMPLEXES WITH JAK2 | TRANSFERASE, INHIBITOR
4c4i:A (LYS714) to (HIS788) STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1 | TRANSFERASE, MITOSIS, STRUCTURE-BASED DRUG DESIGN
4rio:A (SER1005) to (TRP1099) CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRIDAZINE CARBOXAMIDE INHIBITOR | TRANSFERASE, TRANSFERASE-INHIBITOR COMPLEX
4rvt:B (ARG213) to (HIS286) MAP4K4 IN COMPLEX WITH A PYRIDIN-2(1H)-ONE DERIVATIVE | PYRIDIN-2(1H)-ONE LIGAND, TYPE I, DFG-IN, SERINE/THREONINE KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4d0x:A (VAL1033) to (MET1130) PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS | TRANSFERASE, DRUG DISCOVERY, PROTEIN KINASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, POLYCYTHEMIA VERA, TUMOUR CELL PROLIFERATION INHIBITION, ANTI-CANCER AGENTS
4d1s:A (VAL1033) to (MET1130) PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS | TRANSFERASE, KINASE, JAK2, DRUG DISCOVERY, PROTEIN KINASE INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, POLYCYTHEMIA VERA, TUMOUR CELL PROLIFERATION INHIBITION, ANTI-CANCER AGENTS
4u42:A (ASP211) to (HIS286) MAP4K4 T181E MUTANT BOUND TO INHIBITOR COMPOUND 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4u42:B (ARG213) to (HIS286) MAP4K4 T181E MUTANT BOUND TO INHIBITOR COMPOUND 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hez:A (SER1032) to (MET1130) JAK2 KINASE (JH1 DOMAIN) MUTANT P1057A IN COMPLEX WITH TG101209 | PROTEIN KINASE, INHIBITOR, MUTATION, TYK2, SURROGATE, P1104A, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hez:B (VAL1033) to (MET1130) JAK2 KINASE (JH1 DOMAIN) MUTANT P1057A IN COMPLEX WITH TG101209 | PROTEIN KINASE, INHIBITOR, MUTATION, TYK2, SURROGATE, P1104A, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hez:C (SER1032) to (MET1130) JAK2 KINASE (JH1 DOMAIN) MUTANT P1057A IN COMPLEX WITH TG101209 | PROTEIN KINASE, INHIBITOR, MUTATION, TYK2, SURROGATE, P1104A, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hez:D (VAL1033) to (MET1130) JAK2 KINASE (JH1 DOMAIN) MUTANT P1057A IN COMPLEX WITH TG101209 | PROTEIN KINASE, INHIBITOR, MUTATION, TYK2, SURROGATE, P1104A, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ppj:A (GLN636) to (LEU721) HUMAN B-RAF KINASE IN COMPLEX WITH A FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ppj:B (PHE635) to (LEU721) HUMAN B-RAF KINASE IN COMPLEX WITH A FUROPYRIDINE INHIBITOR | PROTEIN KINASE, ATP-COMPETITIVE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e6d:B (VAL1033) to (GLY1132) JAK2 KINASE (JH1 DOMAIN) TRIPLE MUTANT IN COMPLEX WITH COMPOUND 7 | JAK2, KINASE, TRANSFERASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e6q:A (VAL1033) to (GLY1132) JAK2 KINASE (JH1 DOMAIN) TRIPLE MUTANT IN COMPLEX WITH COMPOUND 12 | JAK2, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4e6q:B (VAL1033) to (MET1130) JAK2 KINASE (JH1 DOMAIN) TRIPLE MUTANT IN COMPLEX WITH COMPOUND 12 | JAK2, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r7o:A (THR1261) to (THR1343) STRUCTURE OF DUALLY PHOSPHORYLATED C-MET RECEPTOR KINASE IN COMPLEX WITH AN MK-2461 ANALOG | TYROSINE KINASE, PHOSPHOTYROSINE, 1234, 1235, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gj3:A (ALA1081) to (TYR1176) TYK2 (JH1) IN COMPLEX WITH 2,6-DICHLORO-4-CYANO-N-[2-({[(1R,2R)-2- FLUOROCYCLOPROPYL]CARBONYL}AMINO)PYRIDIN-4-YL]BENZAMIDE | KINASE, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5khx:A (ILE1060) to (LEU1153) CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH PF-4950736 | JAK1, KINASE, INHIBITOR, COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5lwn:A (SER1005) to (ARG1103) CRYSTAL STRUCTURE OF JAK3 IN COMPLEX WITH COMPOUND 5 (FM409) | TRANSFERASE, JAK3, COVALENT INHIBITOR, REVERSIBLE COVALENT INHIBITOR, INDUCED POCKET, ARGININE POCKET, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC