4w9w:A (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH SMALL MOLECULE AZD-7762 | KINASE, SMALL-MOLECULE, CATALYTIC DOMAIN, PROTEIN BINDING, INHIBITOR, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4w9x:A (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH BARICITINIB | KINASE, SMALL-MOLECULE, CATALYTIC DOMAIN, PROTEIN BINDING, INHIBITOR, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
4gs6:A (LYS209) to (PRO292) IRREVERSIBLE INHIBITION OF TAK1 KINASE BY 5Z-7-OXOZEAENOL | KINASE FOLD, TAB1 BINDING, CYTOSOL, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4wa9:B (ILE418) to (GLU507) THE CRYSTAL STRUCTURE OF HUMAN ABL1 WILD TYPE KINASE DOMAIN IN COMPLEX WITH AXITINIB | KINASE, KINASE INHIBITOR, AXITINIB, ACTIVATION LOOP, DFG-OUT, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4wa9:A (ILE418) to (ASP504) THE CRYSTAL STRUCTURE OF HUMAN ABL1 WILD TYPE KINASE DOMAIN IN COMPLEX WITH AXITINIB | KINASE, KINASE INHIBITOR, AXITINIB, ACTIVATION LOOP, DFG-OUT, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4wbb:B (ALA218) to (ALA298) SINGLE TURNOVER AUTOPHOSPHORYLATION CYCLE OF THE PKA RIIB HOLOENZYME | PKA, COMPLEX, SINGLE TURNOVER, OSCILLATIONS, TRANSFERASE
2obj:A (GLY220) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH INHIBITOR | PIM, PIM-1, PIM1, HUMAN PIM-1 KINASE, SERINE/THREONINE KINASE, KINASE INHIBITOR COMPLEX, PYRIDONE, KINASE INHIBITOR, TRANSFERASE
3e8e:A (ALA218) to (ALA298) CRYSTAL STRUCTURES OF THE KINASE DOMAIN OF PKA IN COMPLEX WITH ATP- COMPETITIVE INHIBITORS | PKA, AKT2, KINASE, PKI, BOVINE, INHIBITOR, ATP-BINDING, CAMP, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4gu6:A (THR600) to (GLN686) FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-{3-[(5-CYANO- 2-PHENYL-1H-PYRROLO[2,3-B]PYRIDIN-4-YLAMINO)- METHYL]-PYRIDIN-2-YL}- N-METHYL-METHANESULFONAMIDE | PROTEIN TYROSINE KINASE, ATP BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2ofv:A (ILE419) to (PHE497) CRYSTAL STRUCTURE OF AMINOQUINAZOLINE 1 BOUND TO LCK | LCK, KINASE DOMAIN, TRANSFERASE
4gw8:A (ARG221) to (HIS287) HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND LEUCETTINE L41 | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE, CELL CYCLE, CELL MEMBRANE
2ogv:A (THR833) to (GLN915) CRYSTAL STRUCTURE OF THE AUTOINHIBITED HUMAN C-FMS KINASE DOMAIN | RECEPTOR TYROSINE KINASE, MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR, TRANSFERASE
4wih:A (ASN217) to (ALA299) CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE A FROM CRICETULUS GRISEUS | PKA, KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ATP- BINDING, CAMP, NUCLEOTIDE-BINDING
2oj9:A (THR1161) to (ILE1236) STRUCTURE OF IGF-1R KINASE DOMAIN COMPLEXED WITH A BENZIMIDAZOLE INHIBITOR | HORMONE/GROWTH FACTOR, IGF-1R, KINASE DOMAIN, TRANSFERASE
1ad5:A (ILE441) to (PHE519) SRC FAMILY KINASE HCK-AMP-PNP COMPLEX | TYROSINE-PROTEIN KINASE, TRANSFERASE, SIGNAL TRANSDUCTION, SH2, SH3, PHOSPHORYLATION
4h1m:A (THR603) to (ILE689) CRYSTAL STRUCTURE OF PYK2 WITH THE INDOLE 10C | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4wot:A (GLU274) to (LYS355) ROCK2 IN COMPLEX WITH 1426382-07-1 | TRANSFERASE
4wov:A (ASP796) to (LEU869) CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)- 3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN- 11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE | KINASE, TYK2, PSEUDOKINASE, TRANSFERASE-INHIBITOR COMPLEX
4wov:B (SER792) to (THR867) CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)- 3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN- 11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE | KINASE, TYK2, PSEUDOKINASE, TRANSFERASE-INHIBITOR COMPLEX
4h58:A (PHE634) to (LEU720) BRAF IN COMPLEX WITH COMPOUND 3 | PROTEIN KINASE, STRUCTURE BASED DRUG DISCOVERY, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2b4s:D (THR1187) to (LEU1263) CRYSTAL STRUCTURE OF A COMPLEX BETWEEN PTP1B AND THE INSULIN RECEPTOR TYROSINE KINASE | HYDROLASE/TRANSFERASE, PHOSPHORYLATION, TYROSINE PROTEIN KINASE
3ekn:A (THR1187) to (LEU1263) INSULIN RECEPTOR KINASE COMPLEXED WITH AN INHIBITOR | INSULIN, TYROSINE KINASE, ATP-BINDING, CARBOHYDRATE METABOLISM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DIABETES MELLITUS, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE
3el8:B (ILE441) to (TYR519) CRYSTAL STRUCTURE OF C-SRC IN COMPLEX WITH PYRAZOLOPYRIMIDINE 5 | C-SRC, KINASE, PYRAZOLOPYRIMIDINE 5, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4wrs:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH AN AZASPIRO PYRAZINYL-INDAZOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE
3en5:A (THR440) to (TYR519) TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH PP494, A MULTITARGETED KINASE INHIBITOR | SRC, TYROSINE, KINASE, POLYPHARMACOLOGY, INHIBITOR, MULTITARGET, PHOSPHOINOSITIDE, TRANSFERASE, SIGNALING, PYRAZOLOPYRIMIDINE, KINASE-INHIBITOR COMPLEX, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TYROSINE-PROTEIN KINASE
3en6:A (THR440) to (TYR519) TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH PP102, A MULTITARGETED KINASE INHIBITOR | SRC, TYROSINE, KINASE, POLYPHARMACOLOGY, INHIBITOR, MULTITARGET, PHOSPHOINOSITIDE, TRANSFERASE, SIGNALING, PYRAZOLOPYRIMIDINE, KINASE-INHIBITOR COMPLEX, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TYROSINE-PROTEIN KINASE
3en6:B (ILE441) to (TYR519) TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH PP102, A MULTITARGETED KINASE INHIBITOR | SRC, TYROSINE, KINASE, POLYPHARMACOLOGY, INHIBITOR, MULTITARGET, PHOSPHOINOSITIDE, TRANSFERASE, SIGNALING, PYRAZOLOPYRIMIDINE, KINASE-INHIBITOR COMPLEX, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TYROSINE-PROTEIN KINASE
3en7:B (THR440) to (TYR519) TARGETED POLYPHARMACOLOGY: CRYSTAL STRUCTURE OF THE C-SRC KINASE DOMAIN IN COMPLEX WITH S1, A MULTITARGETED KINASE INHIBITOR | SRC, TYROSINE, KINASE, POLYPHARMACOLOGY, INHIBITOR, MULTITARGET, PHOSPHOINOSITIDE, TRANSFERASE, SIGNALING, PYRAZOLOPYRIMIDINE, KINASE-INHIBITOR COMPLEX, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TYROSINE-PROTEIN KINASE
4wsq:A (THR240) to (LYS316) CRYSTAL STRUCTURE OF ADAPTOR PROTEIN 2 ASSOCIATED KINASE (AAK1) IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, SMALL-MOLECULE, CATALYTIC DOMAIN, PROTEIN KINASE, PROTEIN BINDING, PROTEIN KINASE INHIBITORS, TRANSFERASE
4wsq:B (THR240) to (LYS316) CRYSTAL STRUCTURE OF ADAPTOR PROTEIN 2 ASSOCIATED KINASE (AAK1) IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, SMALL-MOLECULE, CATALYTIC DOMAIN, PROTEIN KINASE, PROTEIN BINDING, PROTEIN KINASE INHIBITORS, TRANSFERASE
3eqp:A (HIS309) to (GLN389) CRYSTAL STRUCTURE OF ACK1 WITH COMPOUND T95 | ACK1, ALTERNATIVE SPLICING, ATP-BINDING, CELL MEMBRANE, KINASE, MAGNESIUM, MEMBRANE, METAL-BINDING, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2bdj:A (ILE441) to (TYR519) SRC KINASE IN COMPLEX WITH INHIBITOR AP23464 | SRC KINASE INHIBITOR, TRANSFERASE
3et7:A (THR603) to (ALA690) CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH PF-2318841 | KINASE, ALTERNATIVE SPLICING, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, TRANSFERASE, TYROSINE-PROTEIN KINASE, SIGNALING PROTEIN
3eta:A (THR1188) to (LEU1263) KINASE DOMAIN OF INSULIN RECEPTOR COMPLEXED WITH A PYRROLO PYRIDINE INHIBITOR | ATP-BINDING, CARBOHYDRATE METABOLISM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DIABETES MELLITUS, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, SIGNALING PROTEIN
3eta:B (THR1188) to (LEU1263) KINASE DOMAIN OF INSULIN RECEPTOR COMPLEXED WITH A PYRROLO PYRIDINE INHIBITOR | ATP-BINDING, CARBOHYDRATE METABOLISM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DIABETES MELLITUS, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, SIGNALING PROTEIN
4hjo:A (THR868) to (ARG949) CRYSTAL STRUCTURE OF THE INACTIVE EGFR TYROSINE KINASE DOMAIN WITH ERLOTINIB | INACTIVE TYROSINE KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2bil:B (ARG221) to (HIS287) THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE | PIM1, KINASE, CANCER, LEUKEMIA, TRANSFERASE
2biy:A (SER262) to (HIS339) STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN | AGC KINASE, AC-HELIX, ATP-BINDING, PHOSPHORYLATION, PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE, PI3-KINASE SIGNALLING, PIF-POCKET, PKA, PKB, T-LOOP MUTANT, SERINE- THREONINE-PROTEIN KINASE, TRANSFERASE
3f2a:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 IN COMPLEX WITH DAPPA | POTEIN KINASE FOLD, ALTERNATIVE INITIATION, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, KINASE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3f3a:A (LYS398) to (HIS510) CRYSTAL STRUCTURE OF LEUT BOUND TO L-TRYPTOPHAN AND SODIUM | SLC6, NSS, TRANSMEMBRANE, SODIUM-COUPLED, TRANSPORTER, SYMPORT, TRANSPORT PROTEIN
3f3t:A (ILE441) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH INHIBITOR RL38 (TYPE III) | ALLOSTERIC, TYPE III, DFG-OUT, ALTERNATIVE SPLICING, ATP- BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
1o6l:A (GLY328) to (HIS406) CRYSTAL STRUCTURE OF AN ACTIVATED AKT/PROTEIN KINASE B (PKB-PIF CHIMERA) TERNARY COMPLEX WITH AMP-PNP AND GSK3 PEPTIDE | PROTEIN KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
3f5p:F (THR1191) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:G (THR1191) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:I (THR1191) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f5p:L (THR1191) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND 3- CYANOQUINOLINE INHIBITOR | IGF-1R, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3f61:A (ARG196) to (GLY279) CRYSTAL STRUCTURE OF M. TUBERCULOSIS PKNB LEU33ASP/VAL222ASP DOUBLE MUTANT IN COMPLEX WITH ADP | PROTEIN KINASE, PKNB, MYCOBACTERIUM TUBERCULOSIS, STRUCTURAL GENOMICS, PKNB KD DOUBLE MUTANT BOUND TO ADP, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, ATP-BINDING, KINASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3f6x:A (ILE441) to (TYR519) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3f6x:B (ILE441) to (TYR519) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3f6x:C (ILE441) to (TYR519) C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR | KINASE, ATP-BINDING, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
4hpt:E (VAL219) to (ALA298) CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE DISPLAYING COMPLETE PHOSPHORYL TRANSFER OF AMP-PNP ONTO A SUBSTRATE PEPTIDE | PROTEIN KINASE, PHOSPHOTRANSFERASE, REGULATORY SUBUNITS, PKI, MAGNESIUM, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3fbv:A (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:B (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:C (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:D (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:E (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:F (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:G (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:H (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:I (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:J (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:K (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:L (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:M (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3fbv:N (SER900) to (TRP981) CRYSTAL STRUCTURE OF THE OLIGOMER FORMED BY THE KINASE-RIBONUCLEASE DOMAIN OF IRE1 | IRE1, RNASE, RIBONUCLEASE, COMPLEX, KINASE, INHIBITOR, OLIGOMER, CYTOPLASMIC, APY29, AMINOPYRAZOLE, ATP-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HYDROLASE, MAGNESIUM, MEMBRANE, METAL- BINDING, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UNFOLDED PROTEIN RESPONSE
3sdj:D (SER900) to (TRP981) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:E (SER900) to (TRP981) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:J (SER900) to (TRP981) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:L (SER900) to (TRP981) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
3sdj:M (SER900) to (TRP981) STRUCTURE OF RNASE-INACTIVE POINT MUTANT OF OLIGOMERIC KINASE/RNASE IRE1 | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, TRANSFERASE, HYDROLASE
2pml:X (ASN224) to (ALA322) CRYSTAL STRUCTURE OF PFPK7 IN COMPLEX WITH AN ATP ANALOGUE | SER/THR PROTEIN KINASE; PLASMODIUM FALCIPARUM; PHOSPHORYLATION; TRANSFERASE, TRANSFERASE
4xey:B (ILE437) to (ASP523) CRYSTAL STRUCTURE OF AN SH2-KINASE DOMAIN CONSTRUCT OF C-ABL TYROSINE KINASE | TYROSINE KINASE, KINASE DOMAIN, SH2 DOMAIN, DASATINIB, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4xey:A (ILE437) to (SER522) CRYSTAL STRUCTURE OF AN SH2-KINASE DOMAIN CONSTRUCT OF C-ABL TYROSINE KINASE | TYROSINE KINASE, KINASE DOMAIN, SH2 DOMAIN, DASATINIB, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2bzh:B (ARG221) to (HIS287) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1 | PIM1, KINASE, CANCER, LEUKEMIA, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE
2bzi:B (ARG221) to (HIS287) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2 | PIM1, KINASE, CANCER, LEUKEMIA, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, TRANSFERASE
2bzk:B (ARG221) to (HIS287) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE | TRANSFERASE-PEPTIDE COMPLEX, COMPLEX TRANSFERASE/PEPTIDE, PIM1, KINASE, CANCER, LEUKEMIA, ATP-BINDING, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2c0i:A (ILE415) to (PHE493) SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983 | TYROSINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHORYLATION, SH2 DOMAIN, SH3 DOMAIN
2c0i:B (ILE415) to (PHE493) SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983 | TYROSINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHORYLATION, SH2 DOMAIN, SH3 DOMAIN
2c0o:A (ILE415) to (PHE493) SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-770041 | TYROSINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHORYLATION, SH2 DOMAIN, SH3 DOMAIN
4xh6:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PROTO-ONCOGENE KINASE PIM1 BOUND TO HISPIDULIN | PIM1, HISPIDULIN, INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xhk:B (ARG221) to (HIS287) PIM1 KINASE IN COMPLEX WITH COMPOUND 1S | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2c3i:B (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I | TRANSFERASE-PEPTIDE COMPLEX, COMPLEX TRANSFERASE/PEPTIDE, PIM1, KINASE, CANCER, LEUKEMIA, ATP-BINDING, NUCLEAR PROTEIN, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4i4f:A (SER601) to (GLN686) STRUCTURE OF FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH AN ALLOSTERIC BINDING PYRAZOLOBENZOTHIAZINE COMPOUND. | PHOSPHORYLATED ON TYROSINES, LOCALIZED TO FOCAL ADHESIONS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3fme:A (VAL236) to (HIS311) CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (MEK6) ACTIVATED MUTANT (S207D, T211D) | KINASE, ACTIVE MUTANT, STRUCTURAL GENOMICS CONSORTIUM, SCG, SGC, ATP- BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE, TYROSINE-PROTEIN KINASE
1opj:A (SER436) to (THR514) STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE | TRANSFERASE
1opj:B (ILE437) to (THR514) STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE | TRANSFERASE
3soc:A (ARG379) to (LEU485) CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH A QUINAZOLIN | STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE, PROTEIN KINASE
4iaa:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH THIORIDAZINE | PIM1 KINASE/ONCOGENE/THIORIDAZINE, SER/THR KINASE, THIORIDAZINE, TRANSFERASE
4iaf:A (VAL219) to (ALA298) ROOM TEMPERATURE X-RAY STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH HIGH MG2+ CONCENTRATION, ADP AND PHOSPHORYLATED PEPTIDE PSP20 | KINASE ENZYME, PHOSPHOTRANSFER, PHOSPHORYLATION, TRANSFERASE-PEPTIDE COMPLEX
4iay:A (ALA218) to (ALA298) ROOM TEMPERATURE X-RAY STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH HIGH SR2+ CONCENTRATION, ADP AND PHOSPHORYLATED PEPTIDE PSP20 | KINASE ENZYME, PHOSPHOTRANSFER, PHOSPHORYLATION, TRANSFERASE-PEPTIDE COMPLEX
4ib3:A (VAL219) to (ALA298) STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH ADP, PHOSPHORYLATED PEPTIDE PSP20, AND NO METAL | KINASE ENZYME, PHOSPHOTRANSFER, PHOSPHORYLATED, TRANSFERASE-PEPTIDE COMPLEX
4ibm:A (THR1187) to (LEU1263) CRYSTAL STRUCTURE OF INSULIN RECEPTOR KINASE DOMAIN IN COMPLEX WITH AN INHIBITOR IRFIN-1 | IRK, KINASE, ATP BINDING, PHOSPHORYLATION, MEMBRANE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4ibm:B (THR1188) to (LEU1263) CRYSTAL STRUCTURE OF INSULIN RECEPTOR KINASE DOMAIN IN COMPLEX WITH AN INHIBITOR IRFIN-1 | IRK, KINASE, ATP BINDING, PHOSPHORYLATION, MEMBRANE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4idt:A (LYS576) to (GLY659) CRYSTAL STRUCTURE OF NIK WITH 11-BROMO-5,6,7,8-TETRAHYDROPYRIMIDO[4', 5':3,4]CYCLOHEPTA[1,2-B]INDOL-2-AMINE (T28) | NIK, NUCLEAR FACTOR (NF)-KB, P100 PROCESSING, 2-AMINOPYRIMIDINE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xmo:A (THR1261) to (SER1342) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH (R)-5-(8-FLUORO-3-(1- FLUORO-1-(3-METHOXYQUINOLIN-6-YL)ETHYL)-[1,2,4]TRIAZOLO[4,3- A]PYRIDIN-6-YL)-3-METHYLISOXAZOLE | RECEPTOR TYROSINE KINASE, INTRACELLULAR CATALYTIC DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1p14:A (THR1187) to (LEU1262) CRYSTAL STRUCTURE OF A CATALYTIC-LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE | RECEPTOR, TYROSINE KINASE, CATALYSIS, MUTANT, TRANSFERASE
3svv:A (ILE441) to (TYR519) CRYSTAL STRUCTURE OF T338C C-SRC COVALENTLY BOUND TO VINYLSULFONAMIDE- PYRAZOLOPYRIMIDINE 9 | COVALENTLY BOUND LIGAND, CYSTEINE GATEKEEPER, SRC, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3fzs:A (THR603) to (ALA690) CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH BIRB796 | PYK2, KINASE, DFG, ALTERNATIVE SPLICING, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, TRANSFERASE, TYROSINE-PROTEIN KINASE
3g0e:A (THR847) to (SER931) KIT KINASE DOMAIN IN COMPLEX WITH SUNITINIB | KIT KINASE DOMAIN, SUTENT BINDING, DRUG RESISTANCE, ATP- BINDING, DISEASE MUTATION, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE
2qcs:A (VAL219) to (ALA298) A COMPLEX STRUCTURE BETWEEN THE CATALYTIC AND REGULATORY SUBUNIT OF PROTEIN KINASE A THAT REPRESENTS THE INHIBITED STATE | CYCLIC ADENOSINE MONOPHOSPHATE, CAMP-DEPENDENT PROTEIN KINASE, PKA HOLOENZYME, CYCLIC NUCLEOTIDE BINDING DOMAIN, PROTEIN-PROTEIN INTERACTION, CONFORMATIONAL CHANGE, PROTEIN BINDING, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3g5d:A (ILE441) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH DASATINIB | TYPE II, DFG-OUT, TYROSINE-PROTEIN KINASE, DASATINIB, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
2qg5:A (GLY202) to (HIS279) CRYPTOSPORIDIUM PARVUM CALCIUM DEPENDENT PROTEIN KINASE CGD7_1840 | MALARIA, CALCIUM DEPENDENT KINASE, SGC, STRUCTURAL GENOMICS CONSORTIUM, TRANSFERASE
3g6g:B (ILE441) to (TYR519) EQUALLY POTENT INHIBITION OF C-SRC AND ABL BY COMPOUNDS THAT RECOGNIZE INACTIVE KINASE CONFORMATIONS | CANCER, IMATINIB RESISTANCE, DSA COMPOUNDS, KINASE, DFG-ASP-OUT, ATP- BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
2qq7:A (ILE441) to (TYR519) CRYSTAL STRUCTURE OF DRUG RESISTANT SRC KINASE DOMAIN WITH IRREVERSIBLE INHIBITOR | SRC KINASE DOMAIN, DRUG RESISTANCE, IRREVERSIBLE INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2qq7:B (THR440) to (TYR519) CRYSTAL STRUCTURE OF DRUG RESISTANT SRC KINASE DOMAIN WITH IRREVERSIBLE INHIBITOR | SRC KINASE DOMAIN, DRUG RESISTANCE, IRREVERSIBLE INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4itj:B (LYS208) to (LYS284) CRYSTAL STRUCTURE OF RIP1 KINASE IN COMPLEX WITH NECROSTATIN-4 | ALPHA/BETA, RIP1 KINASE, NECROPTOSIS, NECROSTATINS, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4xx9:A (SER262) to (HIS339) CRYSTAL STRUCTURE OF PDK1 IN COMPLEX WITH ATP AND THE PIF-POCKET LIGAND RF4 | PROTEIN KINASE, ALLOSTERY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2r2p:A (SER857) to (ASN938) KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5 (EPHA5) | ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, RECEPTOR, SIGNAL, TRANSFERASE, PHOSPHORYLATION, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
1pxp:A (ALA183) to (GLN287) HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]- N',N'-DIMETHYL-BENZENE-1,4-DIAMINE | PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.
3tcp:A (SER779) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC569 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE- BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3gt8:C (THR868) to (ARG949) CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP | INACTIVE KINASE, DIMER, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, CELL MEMBRANE, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, ISOPEPTIDE BOND, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, UBL CONJUGATION
4j7b:A (SER215) to (SER293) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 | FIRST COMPLEX STRUCTURE OF KD AND PBD DOMAIN, REGULATOR OF MITOSIS, PHOSPHORYLATED TARGET PROTEIN, TRANSFERASE
4j95:A (HIS682) to (LEU763) CRYSTAL STRUCURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K659N MUTATION RESPONSIBLE FOR AN UNCLASSIFIED CRANIOSYNOSTOSIS SYNDROME IN SPACE GROUP C2. | KINASE DOMAIN FOLD CONSISTING OF N- AND C-LOBES, RECEPTOR TYROSINE KINASE, ATP BINDING, TRANSFERASE
3thb:A (GLU231) to (ASP302) STRUCTURE OF PLK1 KINASE DOMAIN IN COMPLEX WITH A BENZOLACTAM-DERIVED INHIBITOR | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tku:B (GLY259) to (HIS339) MRCK BETA IN COMPLEX WITH FASUDIL | PROTEIN KINASE, SERINE THREONINE KINASE, MRCK, MRCK BETA, CD BINDING PROTEIN KINASE BETA, FASUDIL, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3tnp:C (ALA218) to (ALA298) STRUCTURE AND ALLOSTERY OF THE PKA RIIB TETRAMERIC HOLOENZYME | PKA RIIB TETRAMERIC HOLOENZYME, TRANSFERASE
3tnp:F (ALA218) to (ALA298) STRUCTURE AND ALLOSTERY OF THE PKA RIIB TETRAMERIC HOLOENZYME | PKA RIIB TETRAMERIC HOLOENZYME, TRANSFERASE
3gxl:A (GLU194) to (GLN298) ALK-5 KINASE COMPLEX WITH GW857175 | TGF-BETA, ALK5, KINASE, INHIBITOR, QUINAZOLINE, AORTIC ANEURYSM, ATP-BINDING, CRANIOSYNOSTOSIS, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, MAGNESIUM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, TRANSMEMBRANE
4jg7:A (ALA586) to (HIS676) STRUCTURE OF RSK2 CTD BOUND TO 3-(3-(1H-PYRROLO[2,3-B]PYRIDINE-3- CARBONYL)PHENYL)-2-CYANOACRYLAMIDE | PROTEIN KINASE, PHOSPHORYLATION, COVALENT INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4yc8:A (ILE418) to (SER501) C-HELIX-OUT BINDING OF DASATINIB ANALOG TO C-ABL KINASE | KINASE, C-HELIX-OUT, TRANSFERASE
4yc8:B (ILE418) to (ILE502) C-HELIX-OUT BINDING OF DASATINIB ANALOG TO C-ABL KINASE | KINASE, C-HELIX-OUT, TRANSFERASE
2rei:A (THR814) to (PRO897) KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7 (EPHA7) | ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, RECEPTOR, SIGNAL, TRANSFERASE, PHOSPHORYLATION, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, ALTERNATIVE SPLICING, GLYCOPROTEIN, STRUCTURAL GENOMICS CONSORTIUM, SGC, POLYMORPHISM
2rf9:B (THR868) to (ARG949) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE | KINASE DOMAIN, INHIBITION, DIMER, PEPTIDE, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, UBL CONJUGATION, CYTOPLASM
2rfe:B (THR868) to (ASP950) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE | KINASE DOMAIN, INHIBITION, DIMER, PEPTIDE, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, UBL CONJUGATION, CYTOPLASM
4yff:A (THR643) to (ASN725) TNNI3K COMPLEXED WITH INHIBITOR 2 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yff:B (THR643) to (ILE726) TNNI3K COMPLEXED WITH INHIBITOR 2 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yff:C (THR643) to (CYS724) TNNI3K COMPLEXED WITH INHIBITOR 2 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yff:D (LYS645) to (CYS724) TNNI3K COMPLEXED WITH INHIBITOR 2 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yfi:B (LYS645) to (MET729) TNNI3K COMPLEXED WITH INHIBITOR 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4yfi:D (LYS645) to (MET729) TNNI3K COMPLEXED WITH INHIBITOR 1 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2e2b:A (ILE418) to (SER500) CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH INNO-406 | C-ABL, KINASE, INNO-406, TRANSFERASE
2e2b:B (ILE418) to (PHE497) CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH INNO-406 | C-ABL, KINASE, INNO-406, TRANSFERASE
3tv4:A (PHE635) to (LEU721) HUMAN B-RAF KINASE DOMAIN IN COMPLEX WITH AN BROMOPYRIDINE BENZAMIDE INHIBITOR | KINASE, KINASE INHIBITOR, TRANSFERASE, RAS, C-RAF, MEK, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4joa:A (LYS1309) to (ASP1389) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 7-AZAINDOLE BASED INHIBITOR | ANAPLASTIC LYMPHOMA KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1qpc:A (ILE419) to (THR501) STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS | ALPHA BETA FOLD, TRANSFERASE
1qpj:A (ILE419) to (THR501) CRYSTAL STRUCTURE OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH STAUROSPORINE. | ALPHA BETA FOLD, TRANSFERASE
3u4w:A (ILE441) to (TYR519) SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC4B | PROTEIN KINASE, SRC-LIKE INACTIVE CONFORMATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2uzb:A (ALA183) to (GLN287) CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR | TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
2uzv:A (VAL219) to (ALA298) PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS | CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, PHOSPHORYLATION, PROTEIN KINASE A, NUCLEOTIDE-BINDING, ATP-BINDING, AKT INHIBITORS, NUCLEAR PROTEIN
4k0y:A (ARG221) to (HIS287) STRUCTURE OF PIM-1 KINASE BOUND TO N-(4-FLUOROPHENYL)-7-HYDROXY-5- (PIPERIDIN-4-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | PIM-1, KINASE, SER/THR KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4k11:A (THR440) to (TYR519) THE STRUCTURE OF 1NA IN COMPLEX WITH SRC T338G | 1NA, C-SRC, KINASE, PHOSPHORYLATION, TRANSFERASE
4k18:A (ARG221) to (HIS287) STRUCTURE OF PIM-1 KINASE BOUND TO 5-(4-CYANOBENZYL)-N-(4- FLUOROPHENYL)-7-HYDROXYPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | PIM-1, KINASE DOMAIN, SER/THR KINASE, ATP-COMPETITIVE, STRUCTURE- BASED DRUG DESIGN, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4k1b:A (ARG221) to (HIS287) STRUCTURE OF PIM-1 KINASE BOUND TO N-(5-(2-FLUOROPHENYL)-1H-PYRROLO[2, 3-B]PYRIDIN-3-YL)-5-((((3R,4R)-3-FLUOROPIPERIDIN-4-YL)METHYL)AMINO) PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE | PIM-1, KINASE DOMAIN, SER/THR KINASE, ATP-COMPETITIVE, STRUCTURE- BASED DRUG DESIGN, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2erz:E (VAL219) to (ALA298) CRYSTAL STRUCTURE OF C-AMP DEPENDENT KINASE (PKA) BOUND TO HYDROXYFASUDIL | FASUDIL KINASE, TRANSFERASE
1fmo:E (ALA218) to (ALA298) CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE | COMPLEX (PHOSPHOTRANSFERASE/INHIBITOR), PHOSPHORYLATION, POLYHISTIDINE-TAG, PROTEIN KINASE
3ue4:A (ILE418) to (ILE502) STRUCTURAL AND SPECTROSCOPIC ANALYSIS OF THE KINASE INHIBITOR BOSUTINIB BINDING TO THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3ue4:B (ILE418) to (ILE502) STRUCTURAL AND SPECTROSCOPIC ANALYSIS OF THE KINASE INHIBITOR BOSUTINIB BINDING TO THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1fpu:A (ILE418) to (PHE497) CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR | KINASE, KINASE INHIBITOR, STI-571, ACTIVATION LOOP, TRANSFERASE
1fpu:B (ILE418) to (PHE497) CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR | KINASE, KINASE INHIBITOR, STI-571, ACTIVATION LOOP, TRANSFERASE
1rej:A (VAL219) to (ALA298) CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 1 | PROTEIN KINASE, NATURAL PRODUCT INHIBITOR, LIGAND BINDING, SPECIFICITY DETERMINANTS, CONFORMATIONAL MALLEABILITY, TRANSFERASE
3uix:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL MOLECULE INHIBITOR | PIM-1, LEUKEMIA CELL LETHALITY, SUBSTRATE-PEPTIDE-BINDING RESIDUE, FLUORESCENT CORRELATION SPECTROSCOPY, INHIBITOR COMPLEX, IN SILICO SCREENING, TRANSFERASE-INHIBITOR COMPLEX
4k9y:A (THR600) to (ALA685) FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-[4-(6-AMINO- PURIN-9-YL)-PHENYL]-3-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-UREA | TYROSINE PROTEIN KINASE, TRANSFERASE, ATP BINDING, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4yxr:A (VAL219) to (ALA298) CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH INHIBITOR. | COMPLEX (PHOSPHOTRANSFERASE-INHIBITOR) COMPLEX, TRANSFERASE
3umw:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR (Z)-2-[(1H- INDAZOL-3-YL)METHYLENE]-6-METHOXY-7-(PIPERAZIN-1-YLMETHYL)BENZOFURAN- 3(2H)-ONE | PIM1, KINASE INHIBITOR, RATIONAL DRUG DESIGN, LEUKEMIA, TRANSFERASE- INHIBITOR COMPLEX
4yzd:C (THR754) to (TRP833) CRYSTAL STRUCTURE OF HUMAN PHOSPHORYLATED IRE1ALPHA IN COMPLEX WITH ADP-MG | ACTIVE, ADP, COMPLEX, IRE1, TRANSFERASE
1rqq:A (THR1188) to (LEU1262) CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH THE SH2 DOMAIN OF APS | PROTEIN TYROSINE KINASE, ADAPTOR PROTEIN, SH2 DOMAIN, TRANSFERASE/SIGNALING PROTEIN COMPLEX
1rqq:B (THR1188) to (LEU1262) CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH THE SH2 DOMAIN OF APS | PROTEIN TYROSINE KINASE, ADAPTOR PROTEIN, SH2 DOMAIN, TRANSFERASE/SIGNALING PROTEIN COMPLEX
4yzn:A (LYS1213) to (LEU1292) HUMANIZED ROCO4 BOUND TO COMPOUND 19 | ROCO-PROTEIN, KINASE, LRRK2, INHIBITOR, ROCO4, TRANSFERASE
2f7x:E (VAL219) to (ALA298) PROTEIN KINASE A BOUND TO (S)-2-(1H-INDOL-3-YL)-1-[5-((E)-2- PYRIDIN-4-YL-VINYL)-PYRIDIN-3-YLOXYMETHYL]-ETHYLAMINE | PROTEIN KINASE A, AKT INHIBITORS, TRANSFERASE
3uo4:A (LYS309) to (HIS380) AURORA A IN COMPLEX WITH RPM1680 | PROTEIN KINASE, AURORA A, INHIBITOR, DFG-IN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3uoj:B (ASP311) to (HIS380) AURORA A IN COMPLEX WITH RPM1715 | PROTEIN KINASE, AURORA A, INHIBITOR, DFG-OUT, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3up7:A (LYS309) to (SER387) AURORA A IN COMPLEX WITH YL1-038-09 | PROTEIN KINASE, AURORA A, INHIBITOR, DFG-IN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3uqg:A (ILE441) to (TYR519) C-SRC KINASE DOMAIN IN COMPLEX WITH BUMPLESS BKI ANALOG UW1243 | TYROSINE PROTEIN KINASE, ATP-BINDING, KINASE DOMAIN, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3uqg:B (ILE441) to (TYR519) C-SRC KINASE DOMAIN IN COMPLEX WITH BUMPLESS BKI ANALOG UW1243 | TYROSINE PROTEIN KINASE, ATP-BINDING, KINASE DOMAIN, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4kio:A (SER537) to (ALA616) KINASE DOMAIN MUTANT OF HUMAN ITK IN COMPLEX WITH A COVALENTLY-BINDING INHIBITOR | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4z7h:A (THR754) to (TRP833) CRYSTAL STRUCTURE OF HUMAN IRE1 CYTOPLASMIC KINASE-RNASE REGION - COMPLEX WITH IMIDAZOPYRIDINE COMPOUND 3 | TRANSFERASE, KINASE, RNASE, UNFOLDED PROTEIN RESPONSE
4z7h:B (THR754) to (TRP833) CRYSTAL STRUCTURE OF HUMAN IRE1 CYTOPLASMIC KINASE-RNASE REGION - COMPLEX WITH IMIDAZOPYRIDINE COMPOUND 3 | TRANSFERASE, KINASE, RNASE, UNFOLDED PROTEIN RESPONSE
3hrc:A (SER262) to (HIS339) CRYSTAL STRUCTURE OF A MUTANT OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ATP | AGC KINASE, PHOSPHORYLATION, ALLOSTERY, PDK1, ACTIVATION LOOP, ATP BINDING, ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3hrf:A (SER262) to (HIS339) CRYSTAL STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH AN ALLOSTERIC ACTIVATOR BOUND TO THE PIF-POCKET | AGC KINASE, PHOSPHORYLATION, ALLOSTERY, PDK1, PIF-POCKET, ALPHA-C HELIX, ACTIVATION LOOP, ATP BINDING, ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4knb:B (THR1261) to (PHE1344) C-MET IN COMPLEX WITH OSI LIGAND | PROTEIN KINASE, TRANSFERASE
4knb:C (THR1262) to (SER1342) C-MET IN COMPLEX WITH OSI LIGAND | PROTEIN KINASE, TRANSFERASE
3v5w:A (ASP369) to (SER450) HUMAN G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH SOLUBLE GBETAGAMMA SUBUNITS AND PAROXETINE | INHIBITOR COMPLEX, PROTEIN KINASE, BETA PROPELLER, RGS HOMOLOGY DOMAIN, PLECKSTRIN HOMOLOGY DOMAIN, KINASE, SIGNAL TRANSDUCTION, PERIPHERAL MEMBRANE PROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2g1t:A (ILE418) to (SER500) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | KINASE, TRANSFERASE
2g1t:B (ILE418) to (ILE502) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | KINASE, TRANSFERASE
2g1t:C (ILE418) to (GLU507) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | KINASE, TRANSFERASE
2g1t:D (SER417) to (ILE502) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | KINASE, TRANSFERASE
2g2h:A (ILE437) to (ASP523) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
2g2i:A (LYS419) to (MET496) A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
3v8t:B (SER536) to (GLY619) CRYSTAL STRUCTURE OF INTERLEUKIN-2 INDUCIBLE T-CELL KINASE ITK CATALYTIC DOMAIN WITH THIENOPYRAZOLYLINDOLE INHIBITOR 477 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbq:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, ROSSMANN FOLD, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbt:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbv:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbw:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vbx:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vby:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vc4:A (ARG221) to (HIS287) EXPLOITATION OF HYDROGEN BONDING CONSTRAINTS AND FLAT HYDROPHOBIC ENERGY LANDSCAPES IN PIM-1 KINASE NEEDLE SCREENING AND INHIBITOR DESIGN | PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1snx:A (SER537) to (GLU617) CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | PROTEIN KINASE, IMMUNOLOGY, TRANSFERASE
1snx:B (SER537) to (GLU617) CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | PROTEIN KINASE, IMMUNOLOGY, TRANSFERASE
2vtr:A (ALA183) to (GLN287) IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6- DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT- BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN. | TRANSFERASE, MITOSIS, CELL CYCLE, SERINE/THREONINE PROTEIN KINASE
3i5n:A (THR1262) to (THR1343) CRYSTAL STRUCTURE OF C-MET WITH TRIAZOLOPYRIDAZINE INHIBITOR 13 | PROTO-ONCOGENE, RTK, RECEPTOR TYROSINE KINASE, SCATTER FACTOR RECEPTOR, HGF/SF, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
2vwi:A (LYS207) to (HIS288) STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET | KINASE, STE KINASE, HYPERTENSION, TRANSFERASE
3i81:A (THR1161) to (SER1235) CRYSTAL STRUCTURE OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF-1R-WT) COMPLEX WITH BMS-754807 [1-(4-((5-CYCLOPROPYL- 1H-PYRAZOL-3-YL)AMINO)PYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)-N- (6-FLUORO-3-PYRIDINYL)-2-METHYL-L-PROLINAMIDE] | HORMONE/GROWTH FACTOR, IGF-1R, KINASE DOMAIN, ATP-BINDING, DISEASE MUTATION, DISULFIDE BOND, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
1gzn:A (ALA330) to (HIS406) STRUCTURE OF PKB KINASE DOMAIN | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING
1gzo:A (ALA330) to (HIS406) STRUCTURE OF PROTEIN KINASE B UNPHOSPHORYLATED | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING
4l00:A (ALA773) to (GLU850) CRYSTAL STRUCTURE OF THE APO JAK1 PSEUDOKINASE DOMAIN | KINASE DOMAIN FOLD, REGULATORY, TRANSFERASE
4l00:B (SER771) to (GLU850) CRYSTAL STRUCTURE OF THE APO JAK1 PSEUDOKINASE DOMAIN | KINASE DOMAIN FOLD, REGULATORY, TRANSFERASE
4l01:A (ALA773) to (GLU850) CRYSTAL STRUCTURE OF THE V658F APO JAK1 PSEUDOKINASE DOMAIN | KINASE DOMAIN FOLD, REGULATORY, TRANSFERASE
4l01:B (SER771) to (GLU849) CRYSTAL STRUCTURE OF THE V658F APO JAK1 PSEUDOKINASE DOMAIN | KINASE DOMAIN FOLD, REGULATORY, TRANSFERASE
1h1w:A (SER262) to (HIS339) HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN | TRANSFERASE, PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE, PKA, AGC KINASE ACTIVATION, PIF-POCKET, PI3-KINASE SIGNALLING, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING
4l3j:A (ASP252) to (HIS326) CRYSTAL STRUCTURES OF HUMAN P70S6K1 KINASE DOMAIN | PROTEIN KINASE, TRANSFERASE
4l42:A (ASP252) to (HIS326) CRYSTAL STRUCTURES OF HUMAN P70S6K1-PIF | PROTEIN KINASE, TRANSFERASE
4zly:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE BOUND TO A CINNOLINE FRAGMENT | CYTOPLASMIC TYROSINE KINASE, TRANSCRIPTIONAL REGULATION, NUCLEAR FACTOR-KAPPAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4zlz:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH A SUBSTITUTED CINNOLINE | CYTOPLASMIC TYROSINE KINASE, TRANSCRIPTIONAL REGULATION, NUCLEAR FACTOR-KAPPAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2gni:A (VAL219) to (ALA298) PKA FIVEFOLD MUTANT MODEL OF RHO-KINASE WITH INHIBITOR FASUDIL (HA1077) | PKA, MUTANT, RHO-KINASE, SURROGATE, INHIBITOR, FASUDIL, HA1077, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
4l6q:A (ASP276) to (HIS351) ROCK2 IN COMPLEX WITH BENZOXABOROLE | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2gqg:A (ILE418) to (GLU499) X-RAY CRYSTAL STRUCTURE OF DASATINIB (BMS-354825) BOUND TO ACTIVATED ABL KINASE DOMAIN | KINASE, TRANSFERASE
2gqg:B (ILE418) to (PHE497) X-RAY CRYSTAL STRUCTURE OF DASATINIB (BMS-354825) BOUND TO ACTIVATED ABL KINASE DOMAIN | KINASE, TRANSFERASE
4zog:A (ILE418) to (SER501) VX-680/MK-0457 BINDS TO HUMAN ABL1 ALSO IN INACTIVE DFG CONFORMATIONS. | KINASE, TRANSFERASE, ABL1, DFG CONFORMATIONS
4zog:B (SER417) to (SER500) VX-680/MK-0457 BINDS TO HUMAN ABL1 ALSO IN INACTIVE DFG CONFORMATIONS. | KINASE, TRANSFERASE, ABL1, DFG CONFORMATIONS
2gs7:A (THR868) to (ARG949) CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP | EGFR, KINASE, INACTIVE, AMP-PNP, TRANSFERASE
2gs7:B (THR868) to (ARG949) CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP | EGFR, KINASE, INACTIVE, AMP-PNP, TRANSFERASE
4l9i:B (ASP367) to (HIS449) BOVINE G PROTEIN COUPLED RECEPTOR KINASE 1 IN COMPLEX WITH PAROXETINE | AGC FAMILY KINASE, SER/THR KINASE, RGS HOMOLOGY DOMAIN, G PROTEIN COUPLED RECEPTOR KINASE, GRK, GRK1, RHODOPSIN KINASE, SSRI, HYDROLYASE, GPCR, PHOSPHORYLATION, TRANSFERASE, MEMBRANE PROTEIN- INHIBITOR COMPLEX
3ik3:A (ILE418) to (LYS512) AP24534, A PAN-BCR-ABL INHIBITOR FOR CHRONIC MYELOID LEUKEMIA, POTENTLY INHIBITS THE T315I MUTANT AND OVERCOMES MUTATION-BASED RESISTANCE | BCR-ABL, CML, T315I, INHIBITOR, MUTATION, DRUG RESISTANCE, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ik3:B (ILE418) to (GLY511) AP24534, A PAN-BCR-ABL INHIBITOR FOR CHRONIC MYELOID LEUKEMIA, POTENTLY INHIBITS THE T315I MUTANT AND OVERCOMES MUTATION-BASED RESISTANCE | BCR-ABL, CML, T315I, INHIBITOR, MUTATION, DRUG RESISTANCE, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
4zse:B (THR892) to (ARG973) CRYSTAL STRUCTURE OF EGFR 696-1022 T790M/V948R, CRYSTAL FORM II | EGFR, T790M, V948R, TRANSFERASE
2w5b:A (ASN194) to (ASN268) HUMAN NEK2 KINASE ATPGAMMAS-BOUND | TRANSFERASE, MEIOSIS, MITOSIS, CYTOPLASM, METAL-BINDING, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, MAGNESIUM, CELL CYCLE, ATP-BINDING, CENTROSOME SPLITTING, CELL DIVISION
2w5h:A (ASN194) to (GLU267) HUMAN NEK2 KINASE APO | SER/THR PROTEIN KINASE, KINASE, NUCLEUS, MEIOSIS, MITOSIS, CYTOPLASM, SERINE/THREONINE-PROTEIN KINASE, METAL-BINDING, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING, MAGNESIUM, CELL CYCLE, ATP-BINDING, TRANSFERASE, CENTROSOME SPLITTING, ALTERNATIVE SPLICING, COILED COIL, POLYMORPHISM, CELL DIVISION
4lgg:A (ILE441) to (TYR519) STRUCTURE OF 3MB-PP1 BOUND TO ANALOG-SENSITIVE SRC KINASE | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lgh:A (ILE441) to (TYR519) CRYSTAL STRUCTURE OF 1NM-PP1 BOUND TO ANALOG-SENSITIVE SRC KINASE | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lgh:B (THR440) to (TYR519) CRYSTAL STRUCTURE OF 1NM-PP1 BOUND TO ANALOG-SENSITIVE SRC KINASE | KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3is5:E (CYS317) to (HIS390) CRYSTAL STRUCTURE OF CDPK KINASE DOMAIN FROM TOXOPLASMA GONDII, TGME49_018720 | TOXOPLASMA GONDII, CDPK, STRUCTURAL GENOMICS, PARASITOLOGY, STRUCTURAL GENOMICS CONSORTIUM, SGC, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
2hck:A (ILE441) to (PHE519) SRC FAMILY KINASE HCK-QUERCETIN COMPLEX | TRANSFERASE, PROTEIN TYROSINE KINASE, SIGNAL TRANSDUCTION, SH2, SH3
4ll5:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM-1 IN COMPLEX WITH THE FLUORESCENT COMPOUND SKF86002 | CO-CRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2hiw:A (SER435) to (PHE515) CRYSTAL STRUCTURE OF INACTIVE CONFORMATION ABL KINASE CATALYTIC DOMAIN COMPLEXED WITH TYPE II INHIBITOR | KINASE DOMAIN, TRANSFERASE
2hiw:B (ILE436) to (MET514) CRYSTAL STRUCTURE OF INACTIVE CONFORMATION ABL KINASE CATALYTIC DOMAIN COMPLEXED WITH TYPE II INHIBITOR | KINASE DOMAIN, TRANSFERASE
3vrz:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 1-[4-(4-AMINO-7-CYCLOPENTYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)PHENYL]- 3-BENZYLUREA | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vrz:B (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 1-[4-(4-AMINO-7-CYCLOPENTYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)PHENYL]- 3-BENZYLUREA | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs1:A (THR440) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 1-[4-(4-AMINO-7-CYCLOPENTYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)PHENYL]- 3-PHENYLUREA | TYROSINE KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs2:A (THR440) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 7-[CIS-4-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL]-5-(4-PHENOXYPHENYL)-7H- PYRROLO[2,3-D]PYRIMIDIN-4-AMINE | TYROSINE KINASE, SRC-FAMILY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs2:B (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 7-[CIS-4-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL]-5-(4-PHENOXYPHENYL)-7H- PYRROLO[2,3-D]PYRIMIDIN-4-AMINE | TYROSINE KINASE, SRC-FAMILY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs3:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 7-[TRANS-4-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL]-5-(4-PHENOXYPHENYL)- 7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2hk5:A (ILE419) to (PHE497) HCK KINASE IN COMPLEX WITH LCK TARGETTED INHIBITOR PG-1009247 | HCK, SRC-FAMILY, KINASE DOMAIN, TRANSFERASE
4lmu:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH THE INHIBITOR QUERCETIN (RESULTING FROM DISPLACEMENT OF SKF86002) | CO-CRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs5:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 7-(1-METHYLPIPERIDIN-4-YL)-5-(4-PHENOXYPHENYL)-7H-PYRROLO[2,3- D]PYRIMIDIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs5:B (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 7-(1-METHYLPIPERIDIN-4-YL)-5-(4-PHENOXYPHENYL)-7H-PYRROLO[2,3- D]PYRIMIDIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs7:A (THR440) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRAZOLO-PYRIMIDINE INHIBITOR 1-CYCLOPENTYL-3-(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-1H- PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lqp:A (GLN590) to (HIS669) CRYSTAL STRUCTURE OF THE CBK1(T743E)-MOB2 KINASE-COACTIVATOR COMPLEX, IN CRYSTAL FORM A | KINASE, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
4lrm:A (THR895) to (ARG976) EGFR D770_N771INSNPG IN COMPLEX WITH PD168393 | EGFR, KINASE, PD168393, 34-JAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4lrm:D (HIS896) to (ARG976) EGFR D770_N771INSNPG IN COMPLEX WITH PD168393 | EGFR, KINASE, PD168393, 34-JAB, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2wnt:A (LYS587) to (HIS672) CRYSTAL STRUCTURE OF THE HUMAN RIBOSOMAL PROTEIN S6 KINASE | ATP-BINDING, POLYMORPHISM, METAL-BINDING, HUMAN, KINASE, RIBOSOMAL, MAGNESIUM, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PHOSPHOPROTEIN, NUCLEOTIDE-BINDING
1i44:A (THR1187) to (LEU1262) CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE | PROTEIN TYROSINE KINASE, PHOSPHOTRANSFERASE
1u3d:A (TRP217) to (GLY279) CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA WITH AMPPNP BOUND | PHOTOLYASE, AMPPNP, SIGNALING PROTEIN
1u59:A (SER517) to (VAL604) CRYSTAL STRUCTURE OF THE ZAP-70 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE | TRANSFERASE
4lue:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH 7-[TRANS-4-(4- METHYLPIPERAZIN-1-YL)CYCLOHEXYL]-5-(4-PHENOXYPHENYL)-7H-PYRROLO[2,3- D]PYRIMIDIN-4-AMINE (RESULTING FROM DISPLACEMENT OF SKF86002) | COCRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3w32:A (THR892) to (ARG973) EGFR KINASE DOMAIN COMPLEXED WITH COMPOUND 20A | ANTI-ONCOGENE, CELL CYCLE, DISEASE MUTATION, KINASE DOMAIN, RECEPTOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2hwo:B (ILE441) to (TYR519) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN IN COMPLEX WITH COVALENT INHIBITOR | KINASE, COVALENT, QUINAZOLINE, MODIFICATION, TRANSFERASE
2hyy:A (ILE418) to (PHE497) HUMAN ABL KINASE DOMAIN IN COMPLEX WITH IMATINIB (STI571, GLIVEC) | TYROSINE KINASE, TRANSFERASE
2hyy:B (ILE418) to (GLN498) HUMAN ABL KINASE DOMAIN IN COMPLEX WITH IMATINIB (STI571, GLIVEC) | TYROSINE KINASE, TRANSFERASE
2hyy:C (ILE418) to (GLN498) HUMAN ABL KINASE DOMAIN IN COMPLEX WITH IMATINIB (STI571, GLIVEC) | TYROSINE KINASE, TRANSFERASE
2hyy:D (ILE418) to (GLN498) HUMAN ABL KINASE DOMAIN IN COMPLEX WITH IMATINIB (STI571, GLIVEC) | TYROSINE KINASE, TRANSFERASE
2hz0:A (ILE418) to (THR495) ABL KINASE DOMAIN IN COMPLEX WITH NVP-AEG082 | TYROSINE KINASE, TRANSFERASE
2hz4:A (ILE418) to (SER500) ABL KINASE DOMAIN UNLIGATED AND IN COMPLEX WITH TETRAHYDROSTAUROSPORINE | TYROSINE KINASE, TRANSFERASE
2hz4:C (ILE418) to (SER500) ABL KINASE DOMAIN UNLIGATED AND IN COMPLEX WITH TETRAHYDROSTAUROSPORINE | TYROSINE KINASE, TRANSFERASE
2hzi:A (ILE418) to (SER500) ABL KINASE DOMAIN IN COMPLEX WITH PD180970 | TYROSINE KINASE, TRANSFERASE
2hzi:B (ILE418) to (SER500) ABL KINASE DOMAIN IN COMPLEX WITH PD180970 | TYROSINE KINASE, TRANSFERASE
2hzn:A (ILE418) to (SER501) ABL KINASE DOMAIN IN COMPLEX WITH NVP-AFG210 | TYROSINE KINASE, TRANSFERASE
4m0z:A (SER536) to (SER618) CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 5 {4- (CARBAMOYLAMINO)-1-(7-METHOXYNAPHTHALEN-1-YL)-1H-PYRAZOLE-3- CARBOXAMIDE} | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4m13:A (SER536) to (SER618) CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 8 [4- (CARBAMOYLAMINO)-1-(7-PROPOXYNAPHTHALEN-1-YL)-1H-PYRAZOLE-3- CARBOXAMIDE] | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4m14:A (SER536) to (ALA616) CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 9 [4- (CARBAMOYLAMINO)-1-[7-(PROPAN-2-YLOXY)NAPHTHALEN-1-YL]-1H-PYRAZOLE-3- CARBOXAMIDE] | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4m15:A (SER537) to (ALA616) CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 9 [4- (CARBAMOYLAMINO)-1-[7-(PROPAN-2-YLOXY)NAPHTHALEN-1-YL]-1H-PYRAZOLE-3- CARBOXAMIDE] AND ADP | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1iep:A (ILE418) to (MET496) CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. | KINASE, KINASE INHIBITOR, STI-571, ACTIVATION LOOP, TRANSFERASE
4m3q:A (SER779) to (SER860) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE- BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4m3q:B (SER779) to (LEU861) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917 | TYROSINE KINASE, ACUTE LYMPHOBLASTIC LEUKEMIA, RATIONAL STRUCTURE- BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4m68:A (ILE378) to (SER454) CRYSTAL STRUCTURE OF THE MOUSE MLKL KINASE-LIKE DOMAIN | KINASE-LIKE, SUBSTRATE OF RIP3, RIP3, SIGNALING PROTEIN
5a9u:A (SER1308) to (ASP1389) STRUCTURE OF C1156Y MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10, 16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO) PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3- CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
1irk:A (THR1187) to (LEU1263) CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR | TRANSFERASE (PHOSPHOTRANSFERASE)
5aa9:A (SER1308) to (ASP1389) STRUCTURE OF L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10, 16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO) PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3- CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR, MUTANT
5aab:A (SER1308) to (ASP1389) STRUCTURE OF C1156Y,L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
5aac:A (SER1308) to (ASP1389) STRUCTURE OF C1156Y MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
3wb8:C (ASP1548) to (GLY1677) CRYSTAL STRUCTURE OF MYOVA-GTD | HELIX BUNDLE, MOTOR PROTEIN
4m8t:A (GLU588) to (HIS676) RSK2 T493M C-TERMINAL KINASE DOMAIN IN COMPLEX WITH 3-(3-(1H-PYRAZOL- 4-YL)PHENYL)-2-CYANOACRYLAMIDE | PROTEIN KINASE, PHOSPHORYLATION, COVALENT INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4mao:A (ALA586) to (HIS676) RSK2 T493M C-TERMINAL KINASE DOMAIN IN COMPLEX WITH RMM58 | PROTEIN KINASE, PHOSPHORYLATION, COVALENT INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4mbi:A (ARG221) to (HIS287) DISCOVERY OF PYRAZOLO[1,5A]PYRIMIDINE-BASED PIM1 INHIBITORS | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mbl:A (ARG221) to (HIS287) DISCOVERY OF PYRAZOLO[1,5A]PYRIMIDINE-BASED PIM1 INHIBITORS | KINASE, PIM1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5ack:A (ASP264) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ALLOSTERIC COMPOUND 7 BOUND TO THE PIF-POCKET | TRANSFERASE, KINASE, ALLOSTERY, VIRTUAL SCREENING, PHARMACOPHORE, MULTICOMPONENT REACTION
1uu7:A (SER262) to (HIS339) STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2 | PROTEIN KINASE, PKB, PDK1, INHIBITOR, LY333531, BISINDOLYL MALEIMIDE, BIM-1, DIABETES, CANCER, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
1uu8:A (SER262) to (HIS339) STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1 | PROTEIN KINASE, PKB, PDK1, INHIBITOR, LY333531, BISINDOLYL MALEIMIDE, BIM-1, DIABETES, CANCER, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
1uu9:A (SER262) to (HIS339) STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3 | PROTEIN KINASE, PKB, PDK1, INHIBITOR, LY333531, BISINDOLYL MALEIMIDE, BIM-1, DIABETES, CANCER, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
3we8:A (ARG221) to (HIS287) PIM-1 KINASE IN COMPLEX WITH RUTHENIUM-BASED INHIBITOR | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3wf6:A (VAL274) to (HIS349) CRYSTAL STRUCTURE OF S6K1 KINASE DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE DERIVATIVE 4-[4-(1H-INDOL-3-YL)-3,6- DIHYDROPYRIDIN-1(2H)-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDINE | SERINE/THREONINE PROTEIN KINASE DOMAIN, TRANSFERASE, PHOSPHORYLATION, ATP-BINDING, ZINC-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3wf9:A (VAL274) to (HIS349) CRYSTAL STRUCTURE OF S6K1 KINASE DOMAIN IN COMPLEX WITH A QUINOLINE DERIVATIVE 1-OXO-1-[(4-SULFAMOYLPHENYL)AMINO]PROPAN-2-YL-2-METHYL-1, 2,3,4-TETRAHYDROACRIDINE-9-CARBOXYLATE | SERINE/THREONINE PROTEIN KINASE DOMAIN, TRANSFERASE, PHOSPHORYLATION, ATP-BINDING, ZINC-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mf0:A (SER536) to (SER618) ITK KINASE DOMAIN IN COMPLEX WITH BENZOTHIAZOLE INHIBITOR COMPOUND 12A (1S,2S)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-N-[6-(PYRIDIN-3-YL)-1,3- BENZOTHIAZOL-2-YL]CYCLOPROPANECARBOXAMIDE (12A) | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mf0:B (SER536) to (GLY619) ITK KINASE DOMAIN IN COMPLEX WITH BENZOTHIAZOLE INHIBITOR COMPOUND 12A (1S,2S)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-N-[6-(PYRIDIN-3-YL)-1,3- BENZOTHIAZOL-2-YL]CYCLOPROPANECARBOXAMIDE (12A) | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mf1:A (SER537) to (GLY619) ITK KINASE DOMAIN IN COMPLEX WITH BENZOTHIAZOLE INHIBITOR 12B (1S,2S)- 2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-N-[6-(1H-PYRAZOL-4-YL)-1,3- BENZOTHIAZOL-2-YL]CYCLOPROPANECARBOXAMIDE | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mf1:B (SER537) to (GLY619) ITK KINASE DOMAIN IN COMPLEX WITH BENZOTHIAZOLE INHIBITOR 12B (1S,2S)- 2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-N-[6-(1H-PYRAZOL-4-YL)-1,3- BENZOTHIAZOL-2-YL]CYCLOPROPANECARBOXAMIDE | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2x39:A (GLY328) to (HIS406) STRUCTURE OF 4-AMINO-N-(4-CHLOROBENZYL)-1-(7H-PYRROLO(2,3-D) PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE BOUND TO PKB | SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, WNT SIGNALING PATHWAY, KINASE, TRANSFERASE, PHOSPHOPROTEIN
2itx:A (THR892) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AMP- PNP | RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, POLYMORPHISM, GLYCOPROTEIN, ANTI-ONCOGENE, NUCLEOTIDE- BINDING, ALTERNATIVE SPLICING, ANP, EGFR, KINASE, AMP-PNP, MEMBRANE, TYROSINE-PROTEIN KINASE, EPIDERMAL GROWTH FACTOR
4mk0:A (SER370) to (SER450) CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH A A RATIONALLY DESIGNED PAROXETINE DERIVATIVE | INHIBITOR COMPLEX, PROTEIN KINASE, HYDROLASE, ATP BINDING, PHOSPHORYLATION, PERIPHERAL MEMBRANE PROTEIN, SIGNALING PROTEIN- INHIBITOR COMPLEX
4mkc:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF ANAPLASTIC LYMPHOMA KINASE COMPLEXED WITH LDK378 | KINASE DOMAIN, PHOSPHOTRANSFERASE, ATP BINDING, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mmb:A (LYS398) to (HIS510) CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH SERTRALINE | TRANSPORTER, TRANSPORT PROTEIN
2xba:A (SER1308) to (ASP1389) STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PHA-E429 | ATP-BINDING, RECEPTOR, TRANSFERASE
5ar5:A (SER207) to (THR296) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BENZIMIDAZOLE | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar5:B (SER207) to (ARG295) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BENZIMIDAZOLE | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar2:B (SER207) to (ARG295) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar3:A (LYS209) to (PHE297) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH AMP-PCP | TRANSFERASE, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar3:B (SER207) to (ARG295) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH AMP-PCP | TRANSFERASE, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar4:A (SER207) to (PHE297) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH SB-203580 | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar4:B (SER207) to (THR296) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH SB-203580 | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar7:A (SER207) to (PHE297) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BIARYL UREA | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar7:B (GLY201) to (THR296) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BIARYL UREA | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar8:A (SER207) to (ARG295) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BIPHENYLSULFONAMIDE | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
5ar8:B (LYS209) to (THR296) RIP2 KINASE CATALYTIC DOMAIN (1 - 310) COMPLEX WITH BIPHENYLSULFONAMIDE | TRANSFERASE, KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY
2j4z:A (ASP307) to (HIS380) STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626 | TRANSFERASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, KINASE, CELL CYCLE, ATP-BINDING, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, SERINE-THREONINE-PROTEIN KINASE
2j50:A (VAL310) to (HIS380) STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358 | TRANSFERASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, KINASE, CELL CYCLE, ATP-BINDING, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, SERINE-THREONINE-PROTEIN KINASE
2j50:B (VAL310) to (HIS380) STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358 | TRANSFERASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, KINASE, CELL CYCLE, ATP-BINDING, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, SERINE-THREONINE-PROTEIN KINASE
2xh5:A (GLY328) to (HIS406) STRUCTURE OF 4-(4-TERT-BUTYLBENZYL)-1-(7H-PYRROLO(2,3-D) PYRIMIDIN-4-YL)PIPERIDIN-4-AMINE BOUND TO PKB | SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, WNT SIGNALING PATHWAY, KINASE, TRANSFERASE, PHOSPHOPROTEIN
1jow:B (PRO199) to (HIS297) CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN CDK6 AND A VIRAL CYCLIN | CDK-CYCLIN COMPLEX, CYCLIN FOLD, CELL CYCLE/TRANSFERASE COMPLEX
2xix:A (ARG221) to (HIS287) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-1 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | ATP-BINDING, PHOSPHORYLATION, TRANSFERASE
2xiy:A (ARG221) to (HIS287) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-2 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | PHOSPHORYLATION, TRANSFERASE
2xiz:A (ARG221) to (HIS287) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-3 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | PHOSPHORYLATION, TRANSFERASE
4mxz:B (ILE441) to (TYR519) SRC M314L T338M DOUBLE MUTANT BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2xp2:A (SER1308) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB (PF-02341066) | CRIZOTINIB, TRANSFERASE
2jds:A (ALA218) to (ALA298) STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A- 443654 | CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION
2jdv:A (ALA218) to (ALA298) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH A-443654 | CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION
5b7v:A (HIS679) to (LEU760) HUMAN FGFR1 KINASE IN COMPLEX WITH CH5183284 | PROTEIN KINASE, ATP-BINDING, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4n6z:A (ARG221) to (HIS287) PIM1 COMPLEXED WITH A PYRIDYLCARBOXAMIDE | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4n70:A (ARG221) to (HIS287) PIM1 COMPLEXED WITH A PYRIDYLCARBOXAMIDE | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5bmm:A (THR440) to (TYR519) SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC25B | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5bmm:B (THR440) to (TYR519) SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC25B | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2jgz:A (ALA183) to (PHE286) CRYSTAL STRUCTURE OF PHOSPHO-CDK2 IN COMPLEX WITH CYCLIN B | PROTEIN KINASE, UBL CONJUGATION, PHOSPHORYLATION, SERINE/THREONINE-PROTEIN KINASE, KINASE, CYCLIN, MITOSIS, CELL CYCLE, TRANSFERASE, ATP-BINDING, POLYMORPHISM, CELL DIVISION, NUCLEOTIDE-BINDING, SUBSTRATE SPECIFICITY
5bpy:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE COMPLEXED WITH BMS-824171 AKA 6-[(3R)-3-(4-TERT-BU TYLBENZAMIDO) PIPERIDIN-1-YL]-2-{[4-(MORPHOLINE-4-CARBONYL) PHENYL]AMINO}PYRIDINE- 3-CARBOXAMIDE | KINASE, INHIBITOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5bq0:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE COMPLEXED WITH BMS-824171 AKA 6-[(3R)-3-(4-TERT-BU TYLBENZAMIDO) PIPERIDIN-1-YL]-2-{[4-(MORPHOLINE-4-CARBONYL) PHENYL]AMINO}PYRIDINE- 3-CARBOXAMIDE | KINASE, INHIBITOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2jit:B (THR892) to (ARG973) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN T790M MUTATION | EGFR, T790M, KINASE, RECEPTOR, CELL CYCLE, PHOSPHORYLATION, DISEASE MUTATION, NUCLEOTIDE-BINDING, TYROSINE-PROTEIN KINASE, ANTI-ONCOGENE, EPIDERMAL GROWTH FACTOR, ATP-BINDING, TRANSFERASE
2jiv:B (THR892) to (ALA972) CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN T790M MUTATION IN COMPEX WITH HKI-272 | HKI272, HKI-272, RECEPTOR, CELL CYCLE, ATP-BINDING, TRANSFERASE, TYROSINE-PROTEIN KINASE, TRANSMEMBRANE, PHOSPHORYLATION, DISEASE MUTATION, NUCLEOTIDE-BINDING, ANTI-ONCOGENE, EPIDERMAL GROWTH FACTOR
3zh8:C (SER424) to (HIS510) A NOVEL SMALL MOLECULE APKC INHIBITOR | TRANSFERASE, AGC KINASES, CELL POLARITY, CELL MIGRATION
1k2p:A (SER575) to (ASP653) CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE DOMAIN | BRUTON TRYOSINE KINASE, KINASE DOMAIN, TRANSFERASE
1k2p:B (LYS577) to (VAL654) CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE DOMAIN | BRUTON TRYOSINE KINASE, KINASE DOMAIN, TRANSFERASE
1k3a:A (THR1161) to (ILE1236) STRUCTURE OF THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR KINASE | PROTEIN KINASE, TYROSINE KINASE, TYROSINE PHOSPHORYLATION, PROTEIN-SUBSTRATE COMPLEX, TRANSFERASE
2xyn:A (ILE464) to (ASP545) HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680 | CELL ADHESION, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
2xyn:B (ILE464) to (ASP545) HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680 | CELL ADHESION, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
1k9a:A (THR365) to (GLU447) CRYSTAL STRUCTURE ANALYSIS OF FULL-LENGTH CARBOXYL-TERMINAL SRC KINASE AT 2.5 A RESOLUTION | CARBOXYL-TERMINAL SRC KINASE, COOH-TERMINAL SRC KINASE, CSK, SRC, SFK, SIGNAL TRANSDUCTION, SH2, SH3, SRC HOMOLOGY, TYROSINE KINASE, CYTOPLASMIC TYROSINE KINASE, CBP, ONCOGENE, CANCER, TRANSFERASE
1k9a:C (THR365) to (GLU447) CRYSTAL STRUCTURE ANALYSIS OF FULL-LENGTH CARBOXYL-TERMINAL SRC KINASE AT 2.5 A RESOLUTION | CARBOXYL-TERMINAL SRC KINASE, COOH-TERMINAL SRC KINASE, CSK, SRC, SFK, SIGNAL TRANSDUCTION, SH2, SH3, SRC HOMOLOGY, TYROSINE KINASE, CYTOPLASMIC TYROSINE KINASE, CBP, ONCOGENE, CANCER, TRANSFERASE
1k9a:E (THR365) to (GLU447) CRYSTAL STRUCTURE ANALYSIS OF FULL-LENGTH CARBOXYL-TERMINAL SRC KINASE AT 2.5 A RESOLUTION | CARBOXYL-TERMINAL SRC KINASE, COOH-TERMINAL SRC KINASE, CSK, SRC, SFK, SIGNAL TRANSDUCTION, SH2, SH3, SRC HOMOLOGY, TYROSINE KINASE, CYTOPLASMIC TYROSINE KINASE, CBP, ONCOGENE, CANCER, TRANSFERASE
5bx7:A (ALA218) to (HIS294) PKA IN COMPLEX WITH A BENZOTHIOPHENE FRAGMENT COMPOUND. | INHIBITOR, PROTEIN KINASE, STRUCTURE-GUIDED, FRAGMENT-BASED, TRANSFERASE
2y4i:B (HIS854) to (LEU931) KSR2-MEK1 HETERODIMER | TRANSFERASE, KSR1
5c01:A (SER792) to (ARG868) CRYSTAL STRUCTURE OF KINASE | PSEUDOKINASE DOMAIN, TRANSFERASE
5c01:B (SER792) to (LEU869) CRYSTAL STRUCTURE OF KINASE | PSEUDOKINASE DOMAIN, TRANSFERASE
5c03:A (SER792) to (LEU869) CRYSTAL STRUCTURE OF KINASE | PSEUDOKINASE DOMAIN, TRANSFERASE
5c03:B (SER792) to (GLN870) CRYSTAL STRUCTURE OF KINASE | PSEUDOKINASE DOMAIN, TRANSFERASE
3zo1:A (ALA218) to (ALA298) THE SYNTHESIS AND EVALUATION OF DIAZASPIROCYCLIC PROTEIN KINASE INHIBITORS | TRANSFERASE-INHIBITOR COMPLEX
3zo2:A (ALA218) to (ALA298) THE SYNTHESIS AND EVALUATION OF DIAZASPIROCYCLIC PROTEIN KINASE INHIBITORS | TRANSFERASE-INHIBITOR COMPLEX
3zo3:A (ALA218) to (ALA298) THE SYNTHESIS AND EVALUATION OF DIAZASPIROCYCLIC PROTEIN KINASE INHIBITORS | TRANSFERASE-INHIBITOR COMPLEX
3zon:A (SER792) to (GLN870) HUMAN TYK2 PSEUDOKINASE DOMAIN BOUND TO A KINASE INHIBITOR | TRANSFERASE, JAK
5c1q:B (ARG221) to (HIS287) SERINE/THREONINE-PROTEIN KINASE PIM-1 | PROTEIN-LIGAND COMPLEX, TRANSFERASE
2yac:A (GLU231) to (THR306) CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH NMS-P937 | TRANSFERASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, NUCLEOTIDE-BINDING, NUCLEUS
2yfx:A (LYS1309) to (ASP1389) STRUCTURE OF L1196M MUTANT ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | NUCLEOTIDE-BINDING, TRANSFERASE, RECEPTOR
2yhv:A (SER1308) to (ASP1389) STRUCTURE OF L1196M MUTANT ANAPLASTIC LYMPHOMA KINASE | TRANSFERASE, RECEPTOR
3zxz:A (THR1261) to (THR1343) X-RAY STRUCTURE OF PF-04217903 BOUND TO THE KINASE DOMAIN OF C-MET | TRANSFERASE, INHIBITOR
3zzw:A (ILE671) to (TRP749) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF ROR2 | TRANSFERASE, NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 2, ROR2, NTRKR2, KINASE, STRUCTURAL GENOMICS CONSORTIUM, SGC
3zzw:B (ILE671) to (TRP749) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF ROR2 | TRANSFERASE, NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 2, ROR2, NTRKR2, KINASE, STRUCTURAL GENOMICS CONSORTIUM, SGC
4a06:A (SER262) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ALLOSTERIC ACTIVATOR PS114 BOUND TO THE PIF-POCKET | TRANSFERASE, ALLOSTERIC SITE
4a07:A (SER262) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ALLOSTERIC ACTIVATOR PS171 BOUND TO THE PIF-POCKET | TRANSFERASE, ALLOSTERIC SITE
4o21:A (VAL219) to (ALA298) PRODUCT COMPLEX OF METAL-FREE PKAC, ATP-GAMMA-S AND SP20. | SER/THR KINASE, PHOSPHORYL TRANSFER, NUCLEOTIDE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4o22:A (VAL219) to (ALA298) BINARY COMPLEX OF METAL-FREE PKAC WITH SP20. | SER/THR KINASE, PHOSPHORYL TRANSFER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2yjs:A (LYS1309) to (ASP1389) STRUCTURE OF C1156Y MUTANT ANAPLASTIC LYMPHOMA KINASE | TRANSFERASE, CRIZOTINIB
4o2p:A (THR440) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH A SUBSTITUTED PYRAZOLOPYRIMIDINE | PYRAZOLO-PYRIMIDINE LIGAND, TYPE I, DFG-IN, TYROSINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1l3r:E (VAL219) to (ALA298) CRYSTAL STRUCTURE OF A TRANSITION STATE MIMIC OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE | PROTEIN KINASE, PROTEIN-ALF3 COMPLEX, TRANSITION STATE MIMIC, TRANSFERASE
3jya:A (ARG221) to (HIS287) DISCOVERY OF 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONES AS POTENT, HIGHLY SELECTIVE AND ORALLY BIOAVAILABLE PIM KINASES INHIBITORS | PIM-1, ALTERNATIVE INITIATION, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, KINASE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
5cnn:B (THR868) to (ARG949) CRYSTAL STRUCTURE OF THE EGFR KINASE DOMAIN MUTANT I682Q | KINASE EGFR, TRANSFERASE
2z60:A (ILE418) to (GLY511) CRYSTAL STRUCTURE OF THE T315I MUTANT OF ABL KINASE BOUND WITH PPY-A | ABL, KINASE, MUTANT, T315I, ALTERNATIVE SPLICING, ATP- BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHORYLATION, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
2o3p:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 WITH QUERCETIN | PIM1, QUERCETIN, TRANSFERASE
2o63:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 WITH MYRICETIN | PIM1, MYRICETIN, TRANSFERASE
2o64:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 WITH QUERCETAGETIN | PIM1, QUERCETAGETIN, TRANSFERASE
2o65:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 WITH PENTAHYDROXYFLAVONE | PIM1, PENTAHYDROXYFLAVONE, TRANSFERASE
1xqz:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HPIM-1 KINASE AT 2.1 A RESOLUTION | PROTEIN KINASE FOLD, TRANSFERASE
1xr1:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HPIM-1 KINASE IN COMPLEX WITH AMP-PNP AT 2.1 A RESOLUTION | PROTEIN KINASE FOLD, TRANSFERASE
1m52:A (ILE418) to (ILE502) CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH PD173955 | KINASE, KINASE INHIBITOR, PD173955, ACTIVATION LOOP, TRANSFERASE
1m52:B (ILE418) to (SER503) CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH PD173955 | KINASE, KINASE INHIBITOR, PD173955, ACTIVATION LOOP, TRANSFERASE
3kex:A (THR870) to (ALA950) CRYSTAL STRUCTURE OF THE CATALYTICALLY INACTIVE KINASE DOMAIN OF THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) | KINASE DOMAIN, INACTIVE KINASE, HER3, ERBB3, ATP-BINDING, CELL MEMBRANE, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TYROSINE-PROTEIN KINASE
3kex:B (THR870) to (ALA950) CRYSTAL STRUCTURE OF THE CATALYTICALLY INACTIVE KINASE DOMAIN OF THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) | KINASE DOMAIN, INACTIVE KINASE, HER3, ERBB3, ATP-BINDING, CELL MEMBRANE, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TYROSINE-PROTEIN KINASE
3kf4:A (ILE418) to (ARG513) STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE | ABL, CML, DRUG RESISTANCE, INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, ONCOGENE, TYROSINE-PROTEIN KINASE, TRANSFERASE
3kf4:B (ILE418) to (SER501) STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE | ABL, CML, DRUG RESISTANCE, INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, ONCOGENE, TYROSINE-PROTEIN KINASE, TRANSFERASE
3kfa:A (ILE418) to (LEU510) STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE | ABL, CML, DRUG RESISTANCE, INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, ONCOGENE, TYROSINE-PROTEIN KINASE, TRANSFERASE
3kfa:B (ILE418) to (LEU510) STRUCTURAL ANALYSIS OF DFG-IN AND DFG-OUT DUAL SRC-ABL INHIBITORS SHARING A COMMON VINYL PURINE TEMPLATE | ABL, CML, DRUG RESISTANCE, INHIBITOR, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, ONCOGENE, TYROSINE-PROTEIN KINASE, TRANSFERASE
2zm1:A (ILE419) to (THR501) CRYSTAL STRUCTURE OF IMIDAZO PYRAZIN 1 BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE- BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
2zm3:A (THR1191) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND ISOQUINOLINEDIONE INHIBITOR | IGFR, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP- BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
2zm3:C (THR1191) to (ILE1266) COMPLEX STRUCTURE OF INSULIN-LIKE GROWTH FACTOR RECEPTOR AND ISOQUINOLINEDIONE INHIBITOR | IGFR, PROTEIN-INHIBITOR COMPLEX, TYROSINE KINASE, ATP- BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
1m7n:A (THR1187) to (ILE1263) CRYSTAL STRUCTURE OF UNACTIVATED APO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE DOMAIN | TRANSFERASE
1m7n:B (THR1188) to (ILE1263) CRYSTAL STRUCTURE OF UNACTIVATED APO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE DOMAIN | TRANSFERASE
4ot6:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 4- METHANESULFONYL-N-(3-{8-[4-(MORPHOLINE-4-CARBONYL)-PHENYLAMINO]- IMIDAZO[1,2-A]PYRAZIN-6-YL}-PHENYL)-BENZAMIDE | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4otd:A (THR799) to (GLN877) CRYSTAL STRUCTURE OF PRK1 CATALYTIC DOMAIN | PRK1, PKN1, PROTEIN KINASE C RELATED KINASE 1, KINASE, PROTEIN KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE
2zv7:A (ILE422) to (PHE500) LYN TYROSINE KINASE DOMAIN, APO FORM | LYN KINASE, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2zv8:A (ILE422) to (PHE500) LYN TYROSINE KINASE DOMAIN-AMP-PNP COMPLEX | LYN KINASE AMPPNP, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2zv9:A (ILE422) to (PHE500) LYN TYROSINE KINASE DOMAIN-PP2 COMPLEX | LYN KINASE PP2, ALTERNATIVE SPLICING, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2zva:A (ILE422) to (PHE500) LYN TYROSINE KINASE DOMAIN-DASATINIB COMPLEX | LYN KINASE DASATINIB, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4ae6:B (VAL219) to (HIS294) STRUCTURE AND FUNCTION OF THE HUMAN SPERM-SPECIFIC ISOFORM OF PROTEIN KINASE A (PKA) CATALYTIC SUBUNIT CALPHA 2 | TRANSFERASE
5d11:B (ILE441) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH RL235 | KINASE INHIBITOR, DRUG RESISTANCE, TRANSFERASE
4af3:A (LYS253) to (HIS324) HUMAN AURORA B KINASE IN COMPLEX WITH INCENP AND VX-680 | TRANSFERASE-INHIBITOR COMPLEX, AURKB
4ag8:A (THR1083) to (ALA1168) CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-METHYL-2-(3-((E)-2-PYRIDIN-2- YL-VINYL)-1H-INDAZOL-6-YLSULFANYL)-BENZAMIDE) | TRANSFERASE, ANGIOGENESIS, NUCLEOTIDE-BINDING, INHIBITOR, PHOSPHORYLATION, TRANSMEMBRANE
4agd:A (THR1083) to (ASN1167) CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2- DIETHYLAMINOETHYL)-5-((Z)-(5-FLUORO-2-OXO-1H-INDOL-3- YLIDENE)METHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE) | TRANSFERASE, ANGIOGENESIS, NUCLEOTIDE-BINDING, INHIBITOR, PHOSPHORYLATION, TRANSMEMBRANE
1y57:A (ILE441) to (TYR519) STRUCTURE OF UNPHOSPHORYLATED C-SRC IN COMPLEX WITH AN INHIBITOR | KINASE STRUCTURE, SH3, SH2, TRANSFERASE
4agw:A (THR440) to (TYR519) DISCOVERY OF A SMALL MOLECULE TYPE II INHIBITOR OF WILD- TYPE AND GATEKEEPER MUTANTS OF BCR-ABL, PDGFRALPHA, KIT, AND SRC KINASES | ATP-BINDING, LIPOPROTEIN, MYRISTATE, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
4agw:B (THR440) to (TYR519) DISCOVERY OF A SMALL MOLECULE TYPE II INHIBITOR OF WILD- TYPE AND GATEKEEPER MUTANTS OF BCR-ABL, PDGFRALPHA, KIT, AND SRC KINASES | ATP-BINDING, LIPOPROTEIN, MYRISTATE, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3kmm:A (ILE419) to (THR501) STRUCTURE OF HUMAN LCK KINASE WITH A SMALL MOLECULE INHIBITOR | TYROSINE KINASE, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
2zyb:A (ILE419) to (THR501) CRYSTAL STRUCTURE OF PHENYLIMIDAZO PYRAZIN 2 BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, KINASE, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, CELL MEMBRANE, POLYMORPHISM
5d7v:A (THR366) to (THR445) CRYSTAL STRUCTURE OF PTK6 KINASE DOMAIN | TRANSFERASE, KINASE, BRK, APO
5d7v:B (THR366) to (ARG440) CRYSTAL STRUCTURE OF PTK6 KINASE DOMAIN | TRANSFERASE, KINASE, BRK, APO
5d7v:C (THR366) to (THR445) CRYSTAL STRUCTURE OF PTK6 KINASE DOMAIN | TRANSFERASE, KINASE, BRK, APO
5d7v:D (SER365) to (THR445) CRYSTAL STRUCTURE OF PTK6 KINASE DOMAIN | TRANSFERASE, KINASE, BRK, APO
3krj:A (VAL834) to (ALA914) CFMS TYROSINE KINASE IN COMPLEX WITH 4-CYANO-1H-IMIDAZOLE-2-CARBOXYLIC ACID (2-CYCLOHEX-1-ENYL-4-PIPERIDIN-4-YL-PHENYL)-AMIDE | KINASE, INHIBITOR, CHIMERA, ATP-BINDING, DISULFIDE BOND, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3a60:A (ARG267) to (HIS349) CRYSTAL STRUCTURE OF UNPHOSPHORYLATED P70S6K1 (FORM I) | KINASE, KINASE DOMAIN, INACTIVE, ACTIVE, RIBOSOMAL S6 KINASE, ACTIVATION, ALTERNATIVE INITIATION, ATP-BINDING, CELL JUNCTION, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, SYNAPSE, SYNAPTOSOME, TRANSFERASE
3a62:A (ASP275) to (HIS349) CRYSTAL STRUCTURE OF PHOSPHORYLATED P70S6K1 | KINASE, KINASE DOMAIN, INACTIVE, ACTIVE, RIBOSOMAL S6 KINASE, ACTIVATION, ALTERNATIVE INITIATION, ATP-BINDING, CELL JUNCTION, CYTOPLASM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, SYNAPSE, SYNAPTOSOME, TRANSFERASE
1yhs:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM-1 BOUND TO STAUROSPORINE | PROTEIN KINASE, PROTO-ONCOGENE, TRANSFERASE
1yi3:A (GLY220) to (HIS287) CRYSTAL STRUCTURE OF PIM-1 BOUND TO LY294002 | PROTEIN KINASE, PI3K, TRANSFERASE
1yi4:A (GLY220) to (HIS287) STRUCTURE OF PIM-1 BOUND TO ADENOSINE | PROTEIN KINASE, PROTO ONCOGENE, TRANSFERASE
1yi6:A (ILE441) to (TYR519) C-TERM TAIL SEGMENT OF HUMAN TYROSINE KINASE (258-533) | SRC, TYROSINE KINASE, PHOSPHORYLATION, REGULATION, SH2, SH3, TRANSFERASE
1yi6:B (ILE441) to (TYR519) C-TERM TAIL SEGMENT OF HUMAN TYROSINE KINASE (258-533) | SRC, TYROSINE KINASE, PHOSPHORYLATION, REGULATION, SH2, SH3, TRANSFERASE
3kul:A (SER817) to (ARG897) KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 8 (EPHA8) | ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, RECEPTOR, TRANSFERASE, PHOSPHORYLATION, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, STRUCTURAL GENOMICS CONSORTIUM, SGC, GLYCOPROTEIN, MEMBRANE, PHOSPHOPROTEIN
3a8w:A (VAL425) to (HIS510) CRYSTAL STRUCTURE OF PKCIOTA KINASE DOMAIN | PROTEIN KINASE C IOTA, KINASE DOMAIN, ATP COMPLEX, TRANSFERASE
3a99:A (ARG221) to (HIS287) STRUCTURE OF PIM-1 KINASE CRYSTALLIZED IN THE PRESENCE OF P27KIP1 CARBOXY-TERMINAL PEPTIDE | PIM-1, P27KIP1, PEPTIDE DRUG, PROSTATE CANCER, TRANSFERASE
3kxz:A (ILE419) to (THR501) THE COMPLEX CRYSTAL STRUCTURE OF LCK WITH A PROBE MOLECULE W259 | LCK, ACETYLATION, ATP-BINDING, CELL MEMBRANE, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, KINASE, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, TRANSFERASE, TYROSINE-PROTEIN KINASE, STRUCTURAL GENOMICS, PROTEIN STRUCTURE FACTORY, PSF
1yoj:A (ILE443) to (TYR521) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN | PROTEIN TYROSINE KINASE, TRANSFERASE
1yoj:B (THR442) to (TYR521) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN | PROTEIN TYROSINE KINASE, TRANSFERASE
1yom:A (THR442) to (TYR521) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN IN COMPLEX WITH PURVALANOL A | PROTEIN TYROSINE KINASE, TRANSFERASE
1yom:B (THR442) to (TYR521) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN IN COMPLEX WITH PURVALANOL A | PROTEIN TYROSINE KINASE, TRANSFERASE
3ac5:A (ILE419) to (THR501) CRYSTAL STRUCTURE OF TRIAZOLO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ac8:A (ILE419) to (THR501) CRYSTAL STRUCTURE OF PYRAZOLO PYRIMIDINE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, ALTERNATIVE SPLICING, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3ad5:A (ILE419) to (THR501) CRYSTAL STRUCTURE OF TRIAZOLONE DERIVATIVE BOUND TO THE KINASE DOMAIN OF HUMAN LCK, (AUTO-PHOSPHORYLATED ON TYR394) | TYROSINE-PROTEIN KINASE, ATP-BINDING, PHOSPHORYLATION, SIGNAL TRANSDUCTION, KINASE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
5dgz:A (ARG221) to (HIS287) DISCOVERY OF 3,5-SUBSTITUTED 6-AZAINDAZOLES AS POTENT PAN-PIM INHIBITORS | PIM-1, KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5dia:A (ARG221) to (HIS287) PIM1 IN COMPLEX WITH CPD36 ((1S,3S)-N1-(6-(5-(PYRIDIN-3-YL)-1H- PYRAZOLO[3,4-C]PYRIDIN-3-YL)PYRIDIN-2-YL)CYCLOHEXANE-1,3-DIAMINE) | PIM-1, KINASE, ATP-COMPETITIVE, STRUCTURE-BASED DRUG DESIGN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3agl:B (ALA218) to (ALA298) COMPLEX OF PKA WITH THE BISUBSTRATE PROTEIN KINASE INHIBITOR ARC-1039 | PKA, PROTEIN KINASE A, BISUBSTRATE INHIBITOR, ARC-1039, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
1ywv:A (ARG221) to (HIS287) CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA | SER/THR PROTEIN KINASE, TRANSFERASE
1yxs:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION | SER/THR PROTEIN KINASE, TRANSFERASE
1yxt:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMPPNP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:B (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:C (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxu:D (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP | SER/THR PROTEIN KINASE, TRANSFERASE
1yxv:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH 3,4-DIHYDROXY-1- METHYLQUINOLIN-2(1H)-ONE | SER/THR PROTEIN KINASE, TRANSFERASE
1yxx:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH (3E)-3-[(4- HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | SER/THR PROTEIN KINASE, TRANSFERASE
4pl5:D (THR754) to (TRP833) CRYSTAL STRUCTURE OF MURINE IRE1 IN COMPLEX WITH OICR573 INHIBITOR | SCHIFF BASE, HYDROXY ARYL ALDEHYDES (HAA), INHIBITOR COMPLEX, UNFOLDED PROTEIN RESPONSE, ENDORIBONUCLEASE
4pnk:A (SER370) to (SER450) G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH GSK180736A | PROTEIN KINASE, HYDROLASE, ATP BINDING, PHOSPHORYLATION, PERIPHERAL MEMBRANE PROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ppa:B (SER536) to (GLY619) ITK KINASE DOMAIN WITH COMPOUND 11 (N-[1-(3-CYANOBENZYL)-1H-PYRAZOL-4- YL]-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE) | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ppb:A (SER537) to (GLY619) ITK KINASE DOMAIN WITH COMPOUND 28 (N-{1-[(1S)-3-(DIMETHYLAMINO)-1- PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3- CARBOXAMIDE) | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ppc:A (SER536) to (SER618) ITK KINASE DOMAIN WITH COMPOUND 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1- PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3- CARBOXAMIDE) | PROTEIN KINASE, PHOSPHO-TRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ppc:B (SER536) to (GLN611) ITK KINASE DOMAIN WITH COMPOUND 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1- PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3- CARBOXAMIDE) | PROTEIN KINASE, PHOSPHO-TRANSFER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4alu:A (GLY220) to (HIS287) BENZOFUROPYRIMIDINONE INHIBITORS OF PIM-1 | PROTO-ONCOGENE, TRANSFERASE
3lct:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF THE ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | KINASE CATALYTIC DOMAIN, ATP-BINDING, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE
4anl:A (SER1308) to (ASP1389) STRUCTURE OF G1269A MUTANT ANAPLASTIC LYMPHOMA KINASE | TRANSFERASE, CRIZOTINIB
4anq:A (SER1308) to (ASP1389) STRUCTURE OF G1269A MUTANT ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE
4ans:A (LYS1309) to (ASP1389) STRUCTURE OF L1196M,G1269A DOUBLE MUTANT ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE
5dwr:A (ARG221) to (HIS287) IDENTIFICATION OF N-(4-((1R,3S,5S)-3-AMINO-5-METHYLCYCLOHEXYL)PYRIDIN- 3-YL)-6-(2,6-DIFLUOROPHENYL)-5-FLUOROPICOLINAMIDE (PIM447), A POTENT AND SELECTIVE PROVIRAL INSERTION SITE OF MOLONEY MURINE LEUKEMIA (PIM) 1,2 AND 3 KINASE INHIBITOR IN CLINICAL TRIALS FOR HEMATOLOGICAL MALIGNANCIES | PIM1, MOLONEY MURINE LEUKEMIA, PIM447, KINASE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4as0:A (ARG221) to (HIS287) CYCLOMETALATED PHTHALIMIDES AS PROTEIN KINASE INHIBITORS | TRANSFERASE, PIM1, OCTASPORINE, RUTHENIUM, KINASE INHIBITOR
4ase:A (ILE1084) to (ALA1168) CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951) | TRANSFERASE, ANGIOGENESIS, SIGNALING PROTEIN, PHOSPHORYLATION, RECEPTOR, INHIBITOR
3lok:A (THR440) to (TYR519) DRUG RESISTANT CSRC KINASE DOMAIN IN COMPLEX WITH COVALENT INHIBITOR PD168393 | SRC KINASE DOMAIN, DRUG RESISTANCE, IRREVERSIBLE INHIBITOR, COVALENT INHIBITOR, PD168393, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TYROSINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3lok:B (ILE441) to (TYR519) DRUG RESISTANT CSRC KINASE DOMAIN IN COMPLEX WITH COVALENT INHIBITOR PD168393 | SRC KINASE DOMAIN, DRUG RESISTANCE, IRREVERSIBLE INHIBITOR, COVALENT INHIBITOR, PD168393, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TYROSINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4at4:A (THR747) to (SER830) CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429 | TRANSFERASE
5e1s:A (THR1187) to (LEU1262) THE CRYSTAL STRUCTURE OF INSR TYROSINE KINASE IN COMPLEX WITH THE INHIBITOR BI 885578 | KINASE, INSR, IGF-1R, INHIBITOR, TRANSFERASE
4aw1:A (SER262) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ALLOSTERIC COMPOUND PS210 BOUND TO THE PIF-POCKET | TRANSFERASE, ALLOSTERIC REGULATION, ALLOSTERIC SITE, PHOSPHORYLATION, AGC PROTEIN KINASE
3lw0:A (THR1190) to (ILE1266) IGF-1RK IN COMPLEX WITH LIGAND MSC1609119A-1 | PROTEIN KINASE, TRANSFERASE
3lw0:B (THR1191) to (ILE1266) IGF-1RK IN COMPLEX WITH LIGAND MSC1609119A-1 | PROTEIN KINASE, TRANSFERASE
3lw0:C (THR1191) to (ILE1266) IGF-1RK IN COMPLEX WITH LIGAND MSC1609119A-1 | PROTEIN KINASE, TRANSFERASE
3lw0:D (THR1191) to (ILE1266) IGF-1RK IN COMPLEX WITH LIGAND MSC1609119A-1 | PROTEIN KINASE, TRANSFERASE
3lzb:A (THR868) to (ARG949) EGFR KINASE DOMAIN COMPLEXED WITH AN IMIDAZO[2,1-B]THIAZOLE INHIBITOR | EPIDERMAL GROWTH FACTOR KINASE DOMAIN, MULTITARGETED SMALL MOLECULE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3lzb:B (THR868) to (ARG949) EGFR KINASE DOMAIN COMPLEXED WITH AN IMIDAZO[2,1-B]THIAZOLE INHIBITOR | EPIDERMAL GROWTH FACTOR KINASE DOMAIN, MULTITARGETED SMALL MOLECULE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3lzb:C (THR868) to (ARG949) EGFR KINASE DOMAIN COMPLEXED WITH AN IMIDAZO[2,1-B]THIAZOLE INHIBITOR | EPIDERMAL GROWTH FACTOR KINASE DOMAIN, MULTITARGETED SMALL MOLECULE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3lzb:D (THR868) to (ARG949) EGFR KINASE DOMAIN COMPLEXED WITH AN IMIDAZO[2,1-B]THIAZOLE INHIBITOR | EPIDERMAL GROWTH FACTOR KINASE DOMAIN, MULTITARGETED SMALL MOLECULE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4qd6:B (SER536) to (SER618) ITK KINASE DOMAIN IN COMPLEX WITH INHIBITOR COMPOUND | PROTEIN KINASE, PHOSPHOTRANSFER CATALYST, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3b2w:A (ILE419) to (ALA500) CRYSTAL STRUCTURE OF PYRIMIDINE AMIDE 11 BOUND TO LCK | LCK, KINASE DOMAIN, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHORYLATION, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3b8q:B (ILE1084) to (GLN1165) CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A NAPHTHAMIDE INHIBITOR | RECEPTOR TYROSINE KINASE, ANGIOGENESIS, ATP-BINDING, DEVELOPMENTAL PROTEIN, DIFFERENTIATION, GLYCOPROTEIN, HOST- VIRUS INTERACTION, IMMUNOGLOBULIN DOMAIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, POLYMORPHISM, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
5ek7:A (SER796) to (ILE875) STRUCTURE OF THE AUTOINHIBITED EPHA2 JMS-KD | EPHA2, KINASE, AUTOINHIBITION, TRANSFERASE
4bdk:A (TYR404) to (HIS483) FRAGMENT-BASED SCREENING IDENTIFIES A NEW AREA FOR INHIBITOR BINDING TO CHECKPOINT KINASE 2 (CHK2) | TRANSFERASE
3bbw:B (THR873) to (ALA953) CRYSTAL STRUCTURE OF THE ERBB4 KINASE IN ITS INACTIVE CONFORMATION | INACTIVE KINASE CONFORMATION, ALTERNATIVE SPLICING, ATP- BINDING, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3bbw:A (THR873) to (ALA953) CRYSTAL STRUCTURE OF THE ERBB4 KINASE IN ITS INACTIVE CONFORMATION | INACTIVE KINASE CONFORMATION, ALTERNATIVE SPLICING, ATP- BINDING, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3mj1:A (SER537) to (ILE615) X-RAY CRYSTAL STRUCTURE OF ITK COMPLEXED WITH INHIBITOR RO5191614 | HELIX C-OUT, TRANSFERASE
3bel:A (THR892) to (ARG973) X-RAY STRUCTURE OF EGFR IN COMPLEX WITH OXIME INHIBITOR | KINASE DOMAIN, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP- BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, UBL CONJUGATION
3mpm:A (ILE419) to (PHE497) LCK COMPLEXED WITH A PYRAZOLOPYRIMIDINE | KINASE DOMAIN, TRANSFERASE
3bgq:A (ARG221) to (HIS287) HUMAN PIM-1 KINASE IN COMPLEX WITH AN TRIAZOLO PYRIDAZINE INHIBITOR VX2 | KINASE INHIBITOR PHOSPHORYLATION, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4bid:A (ALA861) to (ASP935) CRYSTAL STRUCTURES OF ASK1-INHIBITOR COMPLEXES | TRANSFERASE
3bgz:A (ARG221) to (HIS287) HUMAN PIM-1 KINASE IN COMPLEX WITH DIPHENYL INDOLE INHIBITOR VX3 | KINASE INHIBITOR PHOSPHORYLATION, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3ms9:A (ILE418) to (GLN498) ABL KINASE IN COMPLEX WITH IMATINIB AND A FRAGMENT (FRAG1) IN THE MYRISTATE POCKET | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE REGULATOR COMPLEX
3ms9:B (SER417) to (GLN498) ABL KINASE IN COMPLEX WITH IMATINIB AND A FRAGMENT (FRAG1) IN THE MYRISTATE POCKET | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE REGULATOR COMPLEX
3mss:A (ILE418) to (GLN498) ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3mss:B (ILE418) to (GLN498) ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3mss:C (ILE418) to (GLN498) ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3mss:D (ILE418) to (GLN498) ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE | KINASE, FRAGMENT-BASED SCREENING, FBS, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3bkb:A (SER739) to (HIS821) CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V- FES) | FES, V-FES, FUJINAMI, AVIAN SARCOMA, VIRAL, ONCOGENE, FELINE SARCOMA VIRUS, SGC, STRUCTURAL GENOMICS CONSORTIUM, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
5eyd:A (THR1262) to (THR1343) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH AMG 337 | PHOSPHOTRANSFERASE, INHIBITOR, CANCER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3bpr:A (SER779) to (LEU861) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE- PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR C52 | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, IMMUNOGLOBULIN DOMAIN, MEMBRANE, PHOSPHOPROTEIN, POLYMORPHISM, TRANSMEMBRANE
3bpr:B (SER779) to (LEU861) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE- PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR C52 | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, IMMUNOGLOBULIN DOMAIN, MEMBRANE, PHOSPHOPROTEIN, POLYMORPHISM, TRANSMEMBRANE
3bpr:C (SER779) to (LEU861) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE- PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR C52 | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, IMMUNOGLOBULIN DOMAIN, MEMBRANE, PHOSPHOPROTEIN, POLYMORPHISM, TRANSMEMBRANE
3bpr:D (SER779) to (LEU861) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE- PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR C52 | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, IMMUNOGLOBULIN DOMAIN, MEMBRANE, PHOSPHOPROTEIN, POLYMORPHISM, TRANSMEMBRANE
3br5:B (THR45) to (ASN113) CRYSTAL STRUCTURE OF THE COMPLEX OF RHODAMINE 6G BOUND TO QACR(E90Q), A MUTANT OF A MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR | QACR, MULTIDRUG RESISTANCE, TETR, RHODAMINE 6G, DNA-BINDING, PLASMID, REPRESSOR, TRANSCRIPTION, TRANSCRIPTION REGULATION
3mvj:A (ALA218) to (ALA298) HUMAN CYCLIC AMP-DEPENDENT PROTEIN KINASE PKA INHIBITOR COMPLEX | KINASE INHIBITOR, TRANSFERASE
3brb:A (SER779) to (LEU861) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE- PROTEIN KINASE MER IN COMPLEX WITH ADP | ATP-BINDING, DISEASE MUTATION, GLYCOPROTEIN, KINASE, NUCLEOTIDE- BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, RECEPTOR, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, TRANSFERASE, TYROSINE-PROTEIN KINASE, VISION, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, IMMUNOGLOBULIN DOMAIN, MEMBRANE, PHOSPHOPROTEIN, TRANSMEMBRANE
3bu6:A (THR1188) to (LEU1263) CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH IRS2 KRLB PHOSPHOPEPTIDE | IR, IRK, IRS-2, KRLB, INSULIN RECEPTOR, PHOSPHOPEPTIDE, ALTERNATIVE SPLICING, ATP-BINDING, CARBOHYDRATE METABOLISM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DIABETES MELLITUS, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSDUCER
3my0:K (GLU391) to (GLN490) CRYSTAL STRUCTURE OF THE ACVRL1 (ALK1) KINASE DOMAIN BOUND TO LDN- 193189 | PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE RECEPTOR, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3my0:S (GLU391) to (ILE492) CRYSTAL STRUCTURE OF THE ACVRL1 (ALK1) KINASE DOMAIN BOUND TO LDN- 193189 | PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE RECEPTOR, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3my0:W (GLU391) to (SER493) CRYSTAL STRUCTURE OF THE ACVRL1 (ALK1) KINASE DOMAIN BOUND TO LDN- 193189 | PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE RECEPTOR, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3my0:X (GLU391) to (THR488) CRYSTAL STRUCTURE OF THE ACVRL1 (ALK1) KINASE DOMAIN BOUND TO LDN- 193189 | PROTEIN KINASE, SERINE/THREONINE-PROTEIN KINASE RECEPTOR, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE
3bwf:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AN OSMIUM COMPOUND | TRANSFERASE, PIM1, KINASE, ATP-BINDING, PHOSPHORYLATION, ALTERNATIVE INITIATION, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE
4btf:A (ASP377) to (ALA455) STRUCTURE OF MLKL | TRANSFERASE, PSEDUOKINASE, NECROPTOSIS
3bys:A (ILE419) to (THR501) CO-CRYSTAL STRUCTURE OF LCK AND AMINOPYRIMIDINE AMIDE 10B | LCK, KINASE DOMAIN, ALTERNATIVE SPLICING, ATP-BINDING, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, DISEASE MUTATION, HOST-VIRUS INTERACTION, LIPOPROTEIN, MEMBRANE, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3c4c:A (SER634) to (ALA718) B-RAF KINASE IN COMPLEX WITH PLX4720 | B-RAF, BRAF, RAF, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ATP-BINDING, CARDIOMYOPATHY, CYTOPLASM, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ZINC, ZINC-FINGER
3c4e:A (ARG221) to (HIS287) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4e:B (ARG221) to (HIS287) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4e:C (ARG221) to (HIS287) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3c4e:D (ARG221) to (HIS287) PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7- AZAINDOLE | PIM-1, PROTO-ONCOGENE, SERINE/THREONINE KINASE, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4bzn:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH A PYRROLO(1,2-A) PYRAZINONE INHIBITOR | PIM1, ATP BINDING, KINASE INHIBITOR, TRANSFERASE
3cbl:A (SER739) to (HIS821) CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V- FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE | FES, V-FES, FUJINAMI, AVIAN SARCOMA, VIRAL, ONCOGENE, FELINE SARCOMA VIRUS, SGC, STRUCTURAL GENOMICS CONSORTIUM, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3nax:A (ASP264) to (HIS339) PDK1 IN COMPLEX WITH INHIBITOR MP7 | KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
3nay:A (LYS261) to (HIS339) PDK1 IN COMPLEX WITH INHIBITOR MP6 | KINASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE
3ccn:A (THR1261) to (THR1343) X-RAY STRUCTURE OF C-MET WITH TRIAZOLOPYRIDAZINE INHIBITOR. | C-MET KINASE TRIAZOLOPYRIDAZINE, ATP-BINDING, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE
3cd3:A (SER738) to (HIS821) CRYSTAL STRUCTURE OF PHOSPHORYLATED HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE | FES, V-FES, FUJINAMI, AVIAN SARCOMA, VIRAL, ONCOGENE, FELINE SARCOMA VIRUS, ACTIVE, SGC, STRUCTURAL GENOMICS CONSORTIUM, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
4rbl:A (GLY220) to (HIS287) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
4rc2:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
4rc4:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF SER/THR KINASE PIM1 IN COMPLEX WITH MITOXANTRONE DERIVATIVES | KINASE, PHOSPHORYLATION, SIGNALING PROTEIN
3ncz:C (GLU258) to (LYS339) X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A POTENT 2H-ISOQUINOLIN-1-ONE INHIBITOR | RHO KINASE, DIMER, PHOSPHORYLATION, TRANSFERASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4c38:A (ALA218) to (ALA298) PKA-S6K1 CHIMERA WITH COMPOUND 21E (CCT239066) BOUND | TRANSFERASE-INHIBITOR COMPLEX
4c3f:A (ILE419) to (PHE497) STRUCTURE OF LCK IN COMPLEX WITH A COMPOUND DISCOVERED BY VIRTUAL FRAGMENT LINKING | TRANSFERASE
4rfm:A (SER537) to (ALA617) ITK KINASE DOMAIN IN COMPLEX WITH COMPOUND 1 N-{1-[(1,1-DIOXO-1-THIAN- 2-YL)(PHENYL)METHYL]-1H- PYRAZOL-4-YL}-5,5-DIFLUORO-5A-METHYL-1H,4H, 4AH,5H,5AH,6H-CYCLOPROPA[F]INDAZOLE-3-CARBOXAMIDE | KINASE, TRANSFERASE-INHIBITOR COMPLEX
4rfz:A (LYS577) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 6- (DIMETHYLAMINO)-8-FLUORO-2-[2-(HYDROXYMETHYL)-3-[1-METHYL-5-[[5- (MORPHOLINE-4-CARBONYL)-2-PYRIDYL]AMINO]-6-OXO-3- PYRIDYL]PHENYL]ISOQUINOLIN-1-ONE | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3cik:A (SER370) to (SER450) HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS | PROTEIN KINASE, COMPLEX, G PROTEIN, RECEPTOR, WD40 REPEAT, ATP- BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, TRANSDUCER, WD REPEAT, LIPOPROTEIN, MEMBRANE, PHOSPHOPROTEIN, PRENYLATION, TRANSFERASE-SIGNALING PROTEIN COMPLEX
4c57:A (GLY241) to (ASN321) STRUCTURE OF GAK KINASE IN COMPLEX WITH A NANOBODY | TRANSFERASE, KINASE, CONFORMATIONAL PLASTICITY, ACTIVATION
4c8b:A (ASP211) to (ARG295) STRUCTURE OF THE KINASE DOMAIN OF HUMAN RIPK2 IN COMPLEX WITH PONATINIB | TRANSFERASE, STRUCTURAL GENOMICS
4c8b:B (SER207) to (ARG295) STRUCTURE OF THE KINASE DOMAIN OF HUMAN RIPK2 IN COMPLEX WITH PONATINIB | TRANSFERASE, STRUCTURAL GENOMICS
4riw:C (HIS871) to (ARG951) CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER | RECEPTOR TYROSINE KINASE, PSEUDOKINASE, KINASE, ATP BINDING, MEMBRANE, TRANSFERASE
4rix:C (HIS871) to (ARG951) CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-Q790R MUTATION | RECEPTOR TYROSINE KINASE, PSEUDOKINASE, KINASE, ATP BINDING, MEMBRANE, TRANSFERASE
4rix:D (THR868) to (ARG949) CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-Q790R MUTATION | RECEPTOR TYROSINE KINASE, PSEUDOKINASE, KINASE, ATP BINDING, MEMBRANE, TRANSFERASE
4riy:C (HIS871) to (ARG951) CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-E909G MUTATION | RECEPTOR TYROSINE KINASE, PSEUDOKINASE, KINASE, ATP BINDING, MEMBRANE, TRANSFERASE
5frh:A (LEU50) to (ALA95) SOLUTION STRUCTURE OF OXIDISED RSRA | TRANSCRIPTION, ANTI-SIGMA FACTOR, STREPTOMYCES COELICOLOR, REDOX SENSING
4rlo:A (ASN271) to (HIS349) HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR EM5 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rlo:B (ARG267) to (HIS349) HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR EM5 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rlp:A (ASN271) to (HIS349) HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR FL772 | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ccu:A (LYS1309) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPAN-2-OL | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
3cpc:B (ILE1084) to (GLN1165) CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A PYRIDONE INHIBITOR | RECEPTOR TYROSINE KINASE, ANGIOGENESIS, ATP-BINDING, DEVELOPMENTAL PROTEIN, DIFFERENTIATION, GLYCOPROTEIN, HOST-VIRUS INTERACTION, IMMUNOGLOBULIN DOMAIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
5fto:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF THE ALK KINASE DOMAIN IN COMPLEX WITH ENTRECTINIB | TRANSFERASE, KINASE INHIBITORS, CANCER, DRUG DISCOVERY, ALK, TRK, ROS1, ANAPLASTIC LARGE CELL LYMPHOMA (ALCL), NON SMALL CELL LARGE CANCER (NSCLC), NEUROBLASTOMA, COLORECTAL CANCER (CRC)
3nun:A (SER262) to (HIS339) PHOSPHOINOSITIDE-DEPENDENT KINASE-1 (PDK1) WITH LEAD COMPOUND | KINASE DOMAIN, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rqk:A (SER262) to (HIS339) CRYSTAL STRUCTURE OF PDK1 IN COMPLEX WITH ATP AND THE PIF-POCKET LIGAND RS1 | PROTEIN KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rqv:A (SER262) to (HIS339) CRYSTAL STRUCTURE OF PDK1 IN COMPLEX WITH ATP AND THE PIF-POCKET LIGAND RS2 | PROTEIN KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3cs9:A (ILE418) to (SER500) HUMAN ABL KINASE IN COMPLEX WITH NILOTINIB | NILOTINIB, AMN107, KINASE, ABL, ALTERNATIVE SPLICING, ATP- BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ABL KINASE WT IN COMPLEX WITH NVP-AMN107
3cs9:C (SER417) to (PHE497) HUMAN ABL KINASE IN COMPLEX WITH NILOTINIB | NILOTINIB, AMN107, KINASE, ABL, ALTERNATIVE SPLICING, ATP- BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ABL KINASE WT IN COMPLEX WITH NVP-AMN107
3nw5:A (THR1161) to (ILE1236) CRYSTAL STRUCTURE OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF-1R-WT) COMPLEX WITH A CARBON-LINKED PROLINE ISOSTERE INHIBITOR (11B) | HORMONE/GROWTH FACTOR, IGF-1R, KINASE DOMAIN, TRANSFERASE
3nw6:A (THR1160) to (ILE1236) CRYSTAL STRUCTURE OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF-1R-WT) COMPLEX WITH A CARBON-LINKED PROLINE ISOSTERE INHIBITOR (11A) | HORMONE/GROWTH FACTOR, IGF-1R, KINASE DOMAIN, TRANSFERASE
3nw7:A (THR1160) to (SER1235) CRYSTAL STRUCTURE OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF-1R-WT) COMPLEX WITH A CARBON-LINKED PROLINE ISOSTERE INHIBITOR (34) | HORMONE/GROWTH FACTOR, IGF-1R, KINASE DOMAIN, TRANSFERASE
4clj:A (SER1308) to (ASP1389) STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10, 16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO) PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3- CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cmo:A (LYS1309) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 2-((1R)-1-((3-AMINO-6-(2- METHOXYPYRIDIN- -YL)PYRAZIN-2-YL)OXY)ETHYL)-4-FLUORO-N-METHYLBENZAMIDE | TRANSFERASE, RECEPTOR TYROSINE KINASE INHIBITOR
4cmt:A (SER1308) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)-5-(3-(METHYLSULFONYL)PHENYL)PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cmu:A (LYS1309) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (10R)-7-AMINO-12-FLUORO-1,3,10, 16-TETRAMETHYL-16,17-DIHYDRO-1H-8,4-(METHENO)PYRAZOLO(4,3- H)(2,5,11)BENZOXADIAZACYCLOTETRADECIN-15(10H)-ONE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cnh:A (SER1308) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2- METHOXYPHENYL)ETHOXY)-5-(1-METHYL-1H-1,2,3-TRIAZOL-5-YL) PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4cnh:B (SER1308) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2- METHOXYPHENYL)ETHOXY)-5-(1-METHYL-1H-1,2,3-TRIAZOL-5-YL) PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
4rzw:B (PHE635) to (GLU720) CRYSTAL STRUCTURE OF BRAF (R509H) KINASE DOMAIN BOUND TO AZ628 | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3d2k:A (LYS322) to (GLU392) CRYSTAL STRUCTURE OF MOUSE AURORA A (ASN186->GLY, LYS240- >ARG, MET302->LEU) IN COMPLEX WITH [7-(2-{2-[3-(3-CHLORO- PHENYL)-UREIDO]-THIAZOL-5-YL}-ETHYLAMINO)-PYRAZOLO[4,3- D]PYRIMIDIN-1-YL]-ACETIC ACID | AURORA A, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
4crs:A (THR835) to (HIS913) HUMAN PROTEIN KINASE N2 (PKN2, PRKCL2) IN COMPLEX WITH ATPGAMMAS | TRANSFERASE, PRKCL2, PKN2, AGC
4ct1:A (LYS261) to (HIS339) HUMAN PDK1-PKCZETA KINASE CHIMERA IN COMPLEX WITH ALLOSTERIC COMPOUND PS315 BOUND TO THE PIF-POCKET | TRANSFERASE, ALLOSTERIC REGULATION, ALLOSTERIC SITE, PHOSPHORYLATION, AGC PROTEIN KINASE, CHIMERIC PROTEIN
4ct2:A (SER262) to (HIS339) HUMAN PDK1-PKCZETA KINASE CHIMERA | TRANSFERASE, ALLOSTERIC REGULATION, ALLOSTERIC SITE, PHOSPHORYLATION, AGC PROTEIN KINASE, CHIMERIC PROTEIN
3d5x:A (ASP219) to (THR292) CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH WORTMANNIN. | POLO-LIKE KINASE 1, PLK1, CATALYTIC DOMAIN, SMALL-MOLECULE INHIBITOR, KINASE, TRANSFERASE
4ctb:A (LYS1309) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (5R)-8-AMINO-3-FLUORO-5,19-DIMETHYL-20-OXO-5,18,19,20- TETRAHYDRO-7,11-(AZENO)PYRIDO(2',1':2,3)IMIDAZO(4,5-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-14-CARBONITRILE | TRANSFERASE, INHIBITOR
3d7t:B (ILE441) to (ASP518) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK SRC TYROSINE KINASE, ATP-BINDING, CYTOPLASM, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, ALTERNATIVE SPLICING, LIPOPROTEIN, MYRISTATE, PROTO- ONCOGENE
3d7u:A (THR365) to (GLU447) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK C-SRC TYROSINE KINASE, ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, LIPOPROTEIN, MYRISTATE, PROTO-ONCOGENE
3d7u:B (THR440) to (TYR519) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK C-SRC TYROSINE KINASE, ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, LIPOPROTEIN, MYRISTATE, PROTO-ONCOGENE
3d7u:C (THR365) to (GLU447) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK C-SRC TYROSINE KINASE, ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, LIPOPROTEIN, MYRISTATE, PROTO-ONCOGENE
3d7u:D (THR440) to (TYR519) STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK | CSK C-SRC TYROSINE KINASE, ATP-BINDING, KINASE, MEMBRANE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, LIPOPROTEIN, MYRISTATE, PROTO-ONCOGENE
3dcv:A (GLY220) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM1 KINASE COMPLEXED WITH 4-(4- HYDROXY-3-METHYL-PHENYL)-6-PHENYLPYRIMIDIN-2(1H)-ONE | SER/THR PROTEIN KINASE, NUCLEOTIDE-BINDING, PHSPHORYLATION, ATP-BINDING, CANCER, ONCOGENE, ALTERNATIVE INITIATION, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3oez:A (ILE441) to (TYR519) CRYSTAL STRUCTURE OF THE L317I MUTANT OF THE CHICKEN C-SRC TYROSINE KINASE DOMAIN COMPLEXED WITH IMATINIB | C-SRC L317I MUTANT, TYROSINE KINASE, IMATINIB, TRANSFERASE
3of0:A (THR440) to (TYR519) CRYSTAL STRUCTURE OF THE L317I MUTANT OF THE CHICKEN C-SRC TYROSINE KINASE DOMAIN | C-SRC L317I MUTANT, TYROSINE KINASE, TRANSFERASE
3of0:B (THR440) to (TYR519) CRYSTAL STRUCTURE OF THE L317I MUTANT OF THE CHICKEN C-SRC TYROSINE KINASE DOMAIN | C-SRC L317I MUTANT, TYROSINE KINASE, TRANSFERASE
4tt7:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF HUMAN ALK WITH A COVALENT MODIFICATION | ATP-BINDING, RECEPTOR, TRANSFERASE
4d28:C (ASP187) to (ASP261) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SNRK3.11 AT5G35410 | TRANSFERASE, SALT STRESS, SODIUM TRANSPORT, ION HOMEOSTASIS
4d28:D (GLY188) to (ASP261) CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SNRK3.11 AT5G35410 | TRANSFERASE, SALT STRESS, SODIUM TRANSPORT, ION HOMEOSTASIS
3dk3:A (ILE418) to (ILE502) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3dk3:B (ILE418) to (SER500) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3dk6:A (ILE418) to (ILE502) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3dk6:B (ILE418) to (SER500) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
4d2r:A (THR1191) to (ILE1266) HUMAN IGF IN COMPLEX WITH A DYRK1B INHIBITOR | TRANSFERASE, KINASE, INHIBITOR, ONCOLOGY
4d2v:A (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN
4d2v:B (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN
4d2v:C (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN
4d2w:B (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN
4d2w:C (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN
4twp:A (ILE418) to (SER503) THE CRYSTAL STRUCTURE OF HUMAN ABL1 T315I GATEKEEPER MUTANT KINASE DOMAIN IN COMPLEX WITH AXITINIB | GATEKEEPER MUTANT KINASE DOMAIN DFGIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4twp:B (ILE418) to (SER501) THE CRYSTAL STRUCTURE OF HUMAN ABL1 T315I GATEKEEPER MUTANT KINASE DOMAIN IN COMPLEX WITH AXITINIB | GATEKEEPER MUTANT KINASE DOMAIN DFGIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3omv:B (SER526) to (PRO614) CRYSTAL STRUCTURE OF C-RAF (RAF-1) | SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
4ty1:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH AN AMINOOXADIAZOLE-INDOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
3oog:A (VAL219) to (ALA298) HUMAN CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH A SMALL FRAGMENT | TRANSFERASE, ATP BINDING, PHOSPHORYLATION
4tyg:A (HIS668) to (ALA749) STRUCTURAL ANALYSIS OF THE HUMAN FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE | FIBROBLAST GROWTH FACTOR RECEPTOR, KINASE, TRANSFERASE, DOVITINIB, PONATINB, PROTEROS BIOSTRUCTURES GMBH
3dqw:A (ILE441) to (TYR519) C-SRC KINASE DOMAIN THR338ILE MUTANT IN COMPLEX WITH ATPGS | SRC, KINASE, ACTIVE, GATEKEEPER, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3dqx:A (ILE441) to (TYR519) CHICKEN C-SRC KINASE DOMAIN IN COMPLEX WITH ATPGS | SRC, KINASE, ACTIVE, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE- BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3ork:A (ARG196) to (GLY279) MYCOBACTERIUM TUBERCULOSIS PKNB KINASE DOMAIN L33D MUTANT (CRYSTAL FORM 2) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, KINASE DOMAIN, SIGNAL TRANSDUCTION, TRANSFERASE
3oro:A (ARG196) to (GLY279) MYCOBACTERIUM TUBERCULOSIS PKNB KINASE DOMAIN L33D MUTANT (CRYSTAL FORM 4) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, KINASE DOMAIN, SIGNAL TRANSDUCTION, TRANSFERASE
3ort:A (ALA195) to (GLY279) MYCOBACTERIUM TUBERCULOSIS PKNB KINASE DOMAIN L33D MUTANT (CRYSTAL FORM 6) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, KINASE DOMAIN, SIGNAL TRANSDUCTION, TRANSFERASE
3orx:A (LYS261) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT INHIBITOR 1F8 | PIF POCKET, C-HELIX, ACTIVATION LOOP, AGC KINASE, TRANSFERASE, ALLOSTERIC INHIBITOR, PHOSPHORYLATION, ALLOSTERY, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3orx:B (LYS261) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT INHIBITOR 1F8 | PIF POCKET, C-HELIX, ACTIVATION LOOP, AGC KINASE, TRANSFERASE, ALLOSTERIC INHIBITOR, PHOSPHORYLATION, ALLOSTERY, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3orx:C (LYS261) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT INHIBITOR 1F8 | PIF POCKET, C-HELIX, ACTIVATION LOOP, AGC KINASE, TRANSFERASE, ALLOSTERIC INHIBITOR, PHOSPHORYLATION, ALLOSTERY, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3orx:D (LYS261) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT INHIBITOR 1F8 | PIF POCKET, C-HELIX, ACTIVATION LOOP, AGC KINASE, TRANSFERASE, ALLOSTERIC INHIBITOR, PHOSPHORYLATION, ALLOSTERY, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3orx:G (SER262) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT INHIBITOR 1F8 | PIF POCKET, C-HELIX, ACTIVATION LOOP, AGC KINASE, TRANSFERASE, ALLOSTERIC INHIBITOR, PHOSPHORYLATION, ALLOSTERY, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3orz:A (SER262) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT ACTIVATOR 2A2 | C HELIX, SER/THR-KINASE, AGC KINASE, ALLOSTERY, TRANSFERASE, ALLOSTERIC ACTIVATOR, BISINDOLYLMALEIMIDE, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
3orz:C (SER262) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT ACTIVATOR 2A2 | C HELIX, SER/THR-KINASE, AGC KINASE, ALLOSTERY, TRANSFERASE, ALLOSTERIC ACTIVATOR, BISINDOLYLMALEIMIDE, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
3orz:D (SER262) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT ACTIVATOR 2A2 | C HELIX, SER/THR-KINASE, AGC KINASE, ALLOSTERY, TRANSFERASE, ALLOSTERIC ACTIVATOR, BISINDOLYLMALEIMIDE, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
3otu:A (SER262) to (HIS339) PDK1 MUTANT BOUND TO ALLOSTERIC DISULFIDE FRAGMENT ACTIVATOR JS30 | PIF POCKET, ACTIVATION LOOP, C HELIX, SER/THR-KINASE, AGC KINASE, ALLOSTERY, TRANSFERASE, ALLOSTERIC ACTIVATOR, BISINDOLYLMALEIMIDE, PHOSPHORYLATION, DISULFIDE, KINASE, PDK1, TRANSFERASE-TRANSFERASE ACTIVATOR COMPLEX
3ovv:A (ALA218) to (ALA298) HUMAN CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5he0:A (ALA372) to (SER450) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG215022 | RGS, KINASE, PH, WD-40, INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5he2:A (ALA372) to (SER450) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG224406 | RGS, KINASE, PH, WD-40, INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3owp:A (VAL219) to (ALA298) HUMAN CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4dei:A (THR1262) to (THR1343) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH TRIAZOLOPYRIDINONE INHIBITOR 24 | PROTO-ONCOGENE, INHIBITOR, RECEPTOR TYROSINE KINASE, RTK, ATP- BINDING, HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, HGF/SF, PHOSPHOPROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hes:B (THR186) to (ASP266) HUMAN LEUCINE ZIPPER- AND STERILE ALPHA MOTIF-CONTAINING KINASE (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) IN COMPLEX WITH VEMURAFENIB | KINASE, COMPLEX, TRANSFERASE
3oxz:A (SER417) to (GLY511) CRYSTAL STRUCTURE OF ABL KINASE DOMAIN BOUND WITH A DFG-OUT INHIBITOR AP24534 | PROTEIN-INHIBITOR COMPLEX, PROTEIN KINASE TWO-DOMAIN FOLD, PHOSPHOTRANSFERASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3oy3:A (ILE418) to (GLU509) CRYSTAL STRUCTURE OF ABL T315I MUTANT KINASE DOMAIN BOUND WITH A DFG- OUT INHIBITOR AP24589 | PROTEIN-INHIBITOR COMPLEX, PROTEIN KINASE TWO-DOMAIN FOLD, PHOSPHOTRANSFERASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3oy3:B (SER417) to (LEU510) CRYSTAL STRUCTURE OF ABL T315I MUTANT KINASE DOMAIN BOUND WITH A DFG- OUT INHIBITOR AP24589 | PROTEIN-INHIBITOR COMPLEX, PROTEIN KINASE TWO-DOMAIN FOLD, PHOSPHOTRANSFERASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3dy7:A (SER241) to (HIS358) X-RAY STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK1) IN A COMPLEX WITH LIGAND AND MGATP | DUAL SPECIFICITY PROTEIN KINASE, NON-ATP-COMPETITIVE KINASE INHIBITOR, INHIBITOR-BOUND PROTEIN KINASE, ATP-BOUND PROTEIN KINASE, ACETYLATION, ATP-BINDING, DISEASE MUTATION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE- PROTEIN KINASE, TRANSFERASE, TYROSINE-PROTEIN KINASE
4din:A (ALA218) to (ALA298) NOVEL LOCALIZATION AND QUATERNARY STRUCTURE OF THE PKA RI BETA HOLOENZYME | ISOFORM DIVERSITY, RIB2:C2 TETRAMERIC COMPLEX, TRANSFERASE-TRANSPORT PROTEIN COMPLEX
5hhw:A (THR1214) to (LEU1290) CRYSTAL STRUCTURE OF INSULIN RECEPTOR KINASE DOMAIN IN COMPLEX WITH CIS-(R)-7-(3-(AZETIDIN-1-YLMETHYL)CYCLOBUTYL)-5-(3-((TETRAHYDRO-2H- PYRAN-2-YL)METHOXY)PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE. | INHIBITOR, COMPLEX, INSULIN RECEPTOR, KINASE, TRANSFERASE
3p0m:A (VAL219) to (ALA298) HUMAN CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH AN INHIBITOR | TRANSFERASE, PHOSPHORYLATION
5hkm:A (LYS261) to (HIS339) DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS | PDK1 INHIBITOR, TRANSFERASE
5ho7:A (SER262) to (HIS339) DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS | PDK1 INHIBITOR, TRANSFERASE
5hu9:A (ILE418) to (THR495) CRYSTAL STRUCTURE OF ABL1 IN COMPLEX WITH CHMFL-074 | ABL, BCR-ABL, CHMFL-074, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4dtk:A (ARG221) to (HIS287) NOVEL AND SELECTIVE PAN-PIM KINASE INHIBITOR | PIM1, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hzn:B (THR1187) to (ILE1263) STRUCTURE OF NVP-AEW541 IN COMPLEX WITH IGF-1R KINASE | INHIBITOR, KINASE, TRANSFERASE
5hzn:D (THR1188) to (ILE1263) STRUCTURE OF NVP-AEW541 IN COMPLEX WITH IGF-1R KINASE | INHIBITOR, KINASE, TRANSFERASE
5hzn:F (THR1187) to (ILE1263) STRUCTURE OF NVP-AEW541 IN COMPLEX WITH IGF-1R KINASE | INHIBITOR, KINASE, TRANSFERASE
5hzn:H (THR1188) to (ILE1263) STRUCTURE OF NVP-AEW541 IN COMPLEX WITH IGF-1R KINASE | INHIBITOR, KINASE, TRANSFERASE
5i3o:A (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR | TRANSFERASE, PROTEIN KINASE DOMAIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5i3o:B (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR | TRANSFERASE, PROTEIN KINASE DOMAIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5i3r:A (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR | TRANSFERASE, PROTEIN KINASE DOMAIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5i3r:B (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR | TRANSFERASE, PROTEIN KINASE DOMAIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4uj1:A (ALA218) to (ALA298) PROTEIN KINASE A IN COMPLEX WITH AN INHIBITOR | TRANSFERASE-INHIBITOR COMPLEX, PROTEIN KINASE A,
4ujb:A (VAL219) to (ALA298) PROTEIN KINASE A IN COMPLEX WITH AN INHIBITOR | TRANSFERASE
4ump:B (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE
4ump:C (GLY187) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE
4ump:D (LEU186) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE
3piz:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH (5-AMINO-1-O- TOLYL-1H-PYRAZOL-4-YL)-[3-(1-METHANESULFONYL-PIPERIDIN-4-YL)-PHENYL]- METHANONE | HELIX C-IN, DFG-IN, TRANSFERASE, TRANSFERASE-INHIBITOR COMPLEX
3pj2:A (LYS577) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-[4-(2- DIETHYLAMINO-ETHOXY)-PHENYLAMINO]-6-(4-FLUORO-PHENOXY)-8-METHYL-8H- PYRIDO[2,3-D]PYRIMIDIN-7-ONE | HELIX C-OUT, DFG-IN, TRANSFERASE, TRANSFERASE-INHIBITOR COMPLEX
3pj3:A (LYS577) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-METHYL-5-[(E)- (3-PHENYL-ACRYLOYL)AMINO]-N-(2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)- BENZAMIDE | HELIX C-IN, DFG-OUT, TRANSFERASE, TRANSFERASE-INHIBITOR COMPLEX
4e3c:E (THR202) to (LEU309) X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVE CONFORMATION | KANASE, AUTO-PHOSPHORYLATION, NEMO BINDING, TRANSFERASE
3poz:A (THR892) to (ARG973) EGFR KINASE DOMAIN COMPLEXED WITH TAK-285 | KINASE DOMAIN, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5iis:A (ARG221) to (HIS287) DESIGN, SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP OF POTENT PAN- PIM KINASE INHIBITORS DERIVED FROM THE PYRIDYL-AMIDE SCAFFOLD | PIM1, MOLONEY MURINE LEUKEMIA, PIM447, KINASE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4e93:A (SER738) to (ARG822) CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V- FES)IN COMPLEX WITH TAE684 | V-FES, FUJINAMI, AVIAN SARCOMA, VIRAL, ONCOGENE, FELINE SARCOMA VIRUS, ATP-BINDING, KINASE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3psc:A (SER370) to (SER450) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS | KINASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, MEMBRANE, TRANSFERASE-SIGNALING PROTEIN COMPLEX
3psd:B (ASP638) to (LEU721) NON-OXIME PYRAZOLE BASED INHIBITORS OF B-RAF KINASE | KINASE, ATP-BINDING, CARDIOMYOPATHY, DISEASE MUTATION, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, ZINC-FINGER, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
5ikw:A (THR244) to (ALA320) CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH AN INDAZOLE INHIBITOR | TRANSFERASE, PROTEIN KINASE DOMAIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pvu:A (SER370) to (SER450) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND A SELECTIVE KINASE INHIBITOR (CMPD101) | TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, INHIBITOR, MEMBRANE, TRANSFERASE-SIGNALING PROTEIN-INHIBITOR COMPLEX
5imx:A (SER1308) to (ASP1389) ANAPLASTIC LYMPHOMA KINASE (ALK) CATALYTIC DOMAIN COMPLEXED WITH NOVEL INHIBITOR 3-SULFONYLPYRAZOL-4-AMINO PYRIMIDINE | KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pwy:A (SER263) to (HIS339) CRYSTAL STRUCTURE OF AN EXTENDER (SPD28345)-MODIFIED HUMAN PDK1 COMPLEX 2 | KINASE, FRAGMENT-BASED DRUG DISCOVERY, TETHERING WITH EXTENDERS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3py1:A (ALA183) to (GLN287) CDK2 TERNARY COMPLEX WITH SU9516 AND ANS | PROTEIN KINASE, CDK2, ALLOSTERIC LIGAND, ANS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3pyy:A (ILE437) to (SER519) DISCOVERY AND CHARACTERIZATION OF A CELL-PERMEABLE, SMALL-MOLECULE C- ABL KINASE ACTIVATOR THAT BINDS TO THE MYRISTOYL BINDING SITE | TYROSINE KINASE, TRANSFERASE
5ipj:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A QUINAZOLINONE-PYRROLOPYRROLONE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3q4t:A (ARG379) to (MET482) CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH DORSOMORPHIN | STRUCTURAL GENOMICS CONSORTIUM, SGC, PROTEIN KINASE, TRANSFERASE
4uwb:A (THR678) to (LEU760) FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE IN COMPLEX WITH JK-P5 | TRANSFERASE
3q96:B (SER634) to (SER720) B-RAF KINASE DOMAIN IN COMPLEX WITH A TETRAHYDRONAPHTHALENE INHIBITOR | DESIGN, OPTIMIZATION, POTENT, ORALLY BIOAVAILABLE, TETRAHYDRONAPHTHALENE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qam:E (VAL219) to (ALA298) CRYSTAL STRUCTURE OF GLU208ALA MUTANT OF CATALYTIC SUBUNIT OF CAMP- DEPENDENT PROTEIN KINASE | GLU208/ARG280 PAIR;, CATALYTIC SUBUNIT, PKA, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ewh:B (HIS309) to (ALA388) CO-CRYSTAL STRUCTURE OF ACK1 WITH INHIBITOR | DRUG DESIGN, ENZYME INHIBITORS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qc4:A (SER262) to (HIS339) PDK1 IN COMPLEX WITH DFG-OUT INHIBITOR XXX | SERINE/THREONINE KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qc4:B (LYS261) to (HIS339) PDK1 IN COMPLEX WITH DFG-OUT INHIBITOR XXX | SERINE/THREONINE KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qd0:A (SER262) to (HIS339) PHOSPHOINOSITIDE-DEPENDENT KINASE-1 (PDK1) KINASE DOMAIN WITH (2R,5S)- 1-[2-AMINO-6-(3-AMINO-1H-INDAZOL-6-YL)-4-PYRIMIDINYL]-6-METHYL-N- PHENYL-3-PIPERIDINECARBOXAMIDE | KINASE DOMAIN, AGC KINASE, SIGNAL TRANSDUCTION, PHOSPHOINOSITIDE, PHOSPHORYLATION ON S241, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qd3:A (SER262) to (HIS339) PHOSPHOINOSITIDE-DEPENDENT KINASE-1 (PDK1) KINASE DOMAIN WITH 1,1- DIMETHYLETHYL {(3R,6S)-1-[2-AMINO-6-(3-AMINO-1H-INDAZOL-6-YL)-4- PYRIMIDINYL]-6-METHYL-3-PIPERIDINYL}CARBAMATE | KINASE DOMAIN, AGC KINASE, SIGNAL TRANDUCTION, ATP & PHOSPHOINOSITIDE, PHOSPHORYLATION ON S241, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4f0f:A (GLU1212) to (LEU1292) CRYSTAL STRUCTURE OF THE ROCO4 KINASE DOMAIN BOUND TO APPCP FROM D. DISCOIDEUM | PROTEIN KINASE, LRRK2, ROCO, KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SIGNALING PROTEIN
4f0g:A (LYS1213) to (LEU1292) CRYSTAL STRUCTURE OF THE ROCO4 KINASE DOMAIN FROM D. DISCOIDEUM | PROTEIN KINASE, LRRK2, ROCO, ATP-BINDING, NUCLEOTIDE-BINDING, PARKINSON DISEASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SIGNALING PROTEIN
4f1o:A (LYS1213) to (LEU1292) CRYSTAL STRUCTURE OF THE L1180T MUTANT ROCO4 KINASE DOMAIN FROM D. DISCOIDEUM BOUND TO APPCP | PROTEIN KINASE, LRRK2, ROCO, KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SIGNALING PROTEIN
4f1t:A (LYS1213) to (LEU1292) CRYSTAL STRUCTURE OF THE ROCO4 KINASE DOMAIN FROM D. DISCOIDEUM BOUND TO THE ROCK INHIBITOR H1152 | PROTEIN KINASE, LRRK2, ROCO, KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SIGNALING PROTEIN, TRANSFERASE,SIGNALING PROTEIN-INHIBITOR COMPLEX
3qgw:B (SER537) to (ALA616) CRYSTAL STRUCTURE OF ITK KINASE BOUND TO AN INHIBITOR | PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5j5s:B (ILE441) to (TYR519) SRC KINASE IN COMPLEX WITH A SULFONAMIDE INHIBITOR | PROTEIN KINASE, INACTIVE KINASE, SULFONAMIDE INHIBITOR, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
5j79:A (SER207) to (ARG295) THE IDENTIFICATION AND PHARMACOLOGICAL CHARACTERIZATION OF 6-(TERT- BUTYLSULFONYL)-N-(5-FLUORO-1H-INDAZOL-3-YL)QUINOLIN-4-AMINE (GSK583), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF RIP2 KINASE, COMPOUND 3 COMPLEX | KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5j79:B (SER207) to (PHE297) THE IDENTIFICATION AND PHARMACOLOGICAL CHARACTERIZATION OF 6-(TERT- BUTYLSULFONYL)-N-(5-FLUORO-1H-INDAZOL-3-YL)QUINOLIN-4-AMINE (GSK583), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF RIP2 KINASE, COMPOUND 3 COMPLEX | KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5j7b:A (SER204) to (THR296) THE IDENTIFICATION AND PHARMACOLOGICAL CHARACTERIZATION OF 6-(TERT- BUTYLSULFONYL)-N-(5-FLUORO-1H-INDAZOL-3-YL)QUINOLIN-4-AMINE (GSK583), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF RIP2 KINASE, GSK583 COMPLEX | KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5j7b:B (SER207) to (PHE297) THE IDENTIFICATION AND PHARMACOLOGICAL CHARACTERIZATION OF 6-(TERT- BUTYLSULFONYL)-N-(5-FLUORO-1H-INDAZOL-3-YL)QUINOLIN-4-AMINE (GSK583), A HIGHLY POTENT AND SELECTIVE INHIBITOR OF RIP2 KINASE, GSK583 COMPLEX | KINASE DOMAIN, KINASE INHIBITOR, STRUCTURE-BASED DRUG DESIGN, INHIBITOR SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qqu:A (THR1187) to (ILE1263) COCRYSTAL STRUCTURE OF UNPHOSPHORYLATED IGF WITH PYRIMIDINE 8 | IGF, KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qri:A (ILE418) to (MET496) THE CRYSTAL STRUCTURE OF HUMAN ABL1 KINASE DOMAIN IN COMPLEX WITH DCC- 2036 | ABL1, KINASE, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qri:B (ILE418) to (MET496) THE CRYSTAL STRUCTURE OF HUMAN ABL1 KINASE DOMAIN IN COMPLEX WITH DCC- 2036 | ABL1, KINASE, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4feq:A (THR700) to (LEU783) INHIBITOR BOUND STRUCTURE OF THE KINASE DOMAIN OF THE MURINE RECEPTOR TYROSINE KINASE TYRO3 (SKY) | PROTEIN KINASE DOMAIN, RECEPTOR TYROSINE KINASE, GAS6, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3qup:A (THR700) to (HIS782) INHIBITOR BOUND STRUCTURE OF THE KINASE DOMAIN OF THE MURINE RECEPTOR TYROSINE KINASE TYRO3 (SKY) | PROTEIN KINASE INHIBITOR, RECEPTOR TYROSINE KINASE, SPIROCYCLE, KINASE DOMAIN, PHOSPHOTRANSFER, GAS6 LIGAND, CYTOPLASMIC SURFACE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ff8:A (THR700) to (ILE779) INHIBITOR BOUND STRUCTURE OF THE KINASE DOMAIN OF THE MURINE RECEPTOR TYROSINE KINASE TYRO3 (SKY) | RECEPTOR PROTEIN TYROSINE KINASE, PHOSPHOTRANSFERASE, GAS6 (LIGAND), TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r00:A (ARG221) to (HIS287) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r01:A (ARG221) to (HIS287) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINASE, PIM1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r02:A (ARG221) to (HIS287) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINASE, PIM1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3r04:A (ARG221) to (HIS287) THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS AS POTENT PIM-1 INHIBITORS | KINAE, PIM1, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5jcz:B (ASP1548) to (GLY1677) RAB11 BOUND TO MYOVA-GTD | MYOSIN, COMPLEX, RAB, MOTOR CARGO RECOGNITION, MOTOR PROTEIN
5jeb:A (THR868) to (ARG949) CRYSTAL STRUCTURE OF EGFR TYROSINE KINASE DOMAIN WITH NOVEL INHIBITOR OF ACTIVE STATE OF HER2 | INHIBITOR, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5jga:A (SER207) to (PRO292) CRYSTAL STRUCTURE OF HUMAN TAK1/TAB1 FUSION PROTEIN IN COMPLEX WITH LIGAND 11C | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TAK1-TAB1 KINASE
4fnw:A (LYS1309) to (ASP1389) CRYSTAL STRUCTURE OF THE APO F1174L ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, TRANSFERASE
4fob:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH ACYLIMINOBENZIMIDAZOLE INHIBITOR 1 | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, IN SITU PROTEOLYSIS, TRANSFERASE-INHIBITOR COMPLEX
4foc:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH ACYLIMINOBENZIMIDAZOLE INHIBITOR 2 | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, IN SITU PROTEOLYSIS, TRANSFERASE-INHIBITOR COMPLEX
3rcj:A (SER262) to (HIS339) RAPID PREPARATION OF TRIAZOLYL SUBSTITUTED NH-HETEROCYCLIC KINASE INHIBITORS VIA ONE-POT SONOGASHIRA COUPLING TMS-DEPROTECTION CUAAC SEQUENCE | AGC KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3rhk:B (THR1262) to (PHE1344) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF C-MET KINASE IN COMPLEX WITH ARQ 197 | KINASE, RECEPTOR TYROSINE KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fvp:A (ALA733) to (PHE809) CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN (APO FORM) | JANUS PROTEIN KINASE, PSEUDOKINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE
5jrs:B (SER576) to (MET655) CRYSTAL STRUCTURE OF BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE COMPLEXED WITH 4-[2-FLUORO-3-(4-OXO -3,4-DIHYDROQUINAZOLIN-3-YL) PHENYL]-7-(2-HYDROXYPROPAN-2-Y L)-9H-CARBAZOLE-1-CARBOXAMIDE | KINASE, BTK, PROTEIN INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4gg5:A (THR1262) to (THR1343) CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH NOVEL INHIBITOR | CMET INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5kkr:B (HIS854) to (LYS930) KSR2:MEK1 COMPLEX BOUND TO THE SMALL MOLECULE APS-2-79 | KINASE SUPPRESSOR OF RAS SMALL MOLECULE COMPLEX, TRANSFERASE
5kz0:A (LYS1309) to (ASP1389) STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-[(1R)- 1-{[2-AMINO-5-(1,3-DIMETHYL-1H-PYRAZOL-4-YL)PYRIDIN-3-YL]OXY}ETHYL]- 4-FLUORO-N,N-DIMETHYLBENZAMIDE | KINASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5li9:A (SER433) to (HIS519) STRUCTURE OF A NUCLEOTIDE-BOUND FORM OF PKCIOTA CORE KINASE DOMAIN | APKC, POLARITY, COMPLEX, TRANSFERASE
5lvl:A (ASP264) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH COMPOUND PS653 BOUND TO THE ATP-BINDING SITE | PROTEIN KINASE, ALLOSTERIC REGULATION, SMALL COMPOUNDS, PIF-POCKET, TRANSFERASE
5lvn:A (ASP264) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ADENOSINE BOUND TO THE ATP- BINDING SITE | PROTEIN KINASE, ALLOSTERIC REGULATION, SMALL COMPOUNDS, PIF-POCKET, TRANSFERASE
5lvo:A (SER262) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ALLOSTERIC COMPOUND PSE10 BOUND TO THE PIF-POCKET | PROTEIN KINASE, ALLOSTERIC REGULATION, SMALL COMPOUNDS, PIF-POCKET, TRANSFERASE
5te0:A (THR240) to (LYS316) CRYSTAL STRUCTURE OF ADAPTOR PROTEIN 2 ASSOCIATED KINASE (AAK1) IN COMPLEX WITH BIBF 1120 | TRANSFERASE, PROTEIN KINASE DOMAIN, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
2oi4:X (GLY220) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH FLUORINATED RUTHENIUM PYRIDOCARBAZOLE | TRANSFERASE,PIM1,KINASE, ATP-BINDING,PHOSPHORYLATION
3ekk:A (THR1187) to (LEU1263) INSULIN RECEPTOR KINASE COMPLEXED WITH AN INHIBITOR | INSULIN, TYROSINE KINASE, ATP-BINDING, CARBOHYDRATE METABOLISM, CLEAVAGE ON PAIR OF BASIC RESIDUES, DIABETES MELLITUS, DISEASE MUTATION, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE
4wt6:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A THIADIAZOLAMINE-INDOLE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE
2bcj:A (ASP373) to (SER450) CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH GALPHA-Q AND GBETAGAMMA SUBUNITS | PERIPHERAL MEMBRANE COMPLEX, PROTEIN KINASE, RGS DOMAIN, WD40 PROTEIN, HETEROTRIMERIC G PROTEIN, TRANSFERASE-HYDROLASE COMPLEX
2bdf:B (ILE441) to (TYR519) SRC KINASE IN COMPLEX WITH INHIBITOR AP23451 | SRC KINASE INHIBITOR, TRANSFERASE
2bik:B (ARG221) to (HIS287) HUMAN PIM1 PHOSPHORYLATED ON SER261 | KINASE, CANCER, LEUKEMIA, TRANSFERASE, ATP-BINDING
3sdm:A (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:B (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:C (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:D (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:E (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:F (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
3sdm:G (SER900) to (TRP981) STRUCTURE OF OLIGOMERIC KINASE/RNASE IRE1 IN COMPLEX WITH AN OLIGONUCLEOTIDE | KINASE, RNASE, RIBONUCLEASE, HAC1, XBP1, SPLICING, RNA, UPR, UNFOLDED PROTEIN RESPONSE, OLIGOMER, COMPLEX, OLIGONUCLEOTIDE, TRANSFERASE, HYDROLASE
2c0t:A (ILE415) to (PHE493) SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359 | TRANSFERASE, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, SH2 DOMAIN, SH3 DOMAIN
2c0t:B (ILE415) to (PHE493) SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359 | TRANSFERASE, ATP-BINDING, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PALMITATE, SH2 DOMAIN, SH3 DOMAIN
2c1a:A (ALA218) to (ALA298) STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE | TRANSFERASE/INHIBITOR, COMPLEX (TRANSFERASE/INHIBITOR), ATP-BINDING, CAMP, PHOSPHORYLATION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PROTEIN KINASE INHIBITOR
4xi2:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF AN AUTO-INHIBITED FORM OF BRUTON'S TRYROSINE KINASE | KINASE, PHOSPHORYLATION, AUTO-INHIBITED, B-CELL DEVELOPMENT, X-LINKED AGAMMAGLOBULINEMIA, TRANSFERASE
3fjq:E (VAL219) to (ALA298) CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA IN COMPLEX WITH PEPTIDE INHIBITOR PKI ALPHA (6-25) | NUCLEOTIDE BINDING, PROTEIN KINASE ACTIVITY, PROTEIN SERINE/THREONINE KINASE ACTIVITY, CAMP-DEPENDENT PROTEIN KINASE ACTIVITY, PROTEIN BINDING, ATP BINDING, KINASE ACTIVITY, TRANSFERASE ACTIVITY, ALTERNATIVE SPLICING, ATP- BINDING, CAMP, CYTOPLASM, KINASE, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, PROTEIN KINASE INHIBITOR
2qi8:A (ILE441) to (TYR519) CRYSTAL STRUCTURE OF DRUG RESISTANT SRC KINASE DOMAIN | SRC KINASE DOMAIN; DRUG RESISTANCE, SIGNALING PROTEIN, TRANSFERASE
3g6h:A (ILE441) to (TYR519) SRC THR338ILE INHIBITED IN THE DFG-ASP-OUT CONFORMATION | CANCER, IMATINIB RESISTANCE, DSA COMPOUNDS, KINASE, DFG-ASP- OUT, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
3g6h:B (ILE441) to (TYR519) SRC THR338ILE INHIBITED IN THE DFG-ASP-OUT CONFORMATION | CANCER, IMATINIB RESISTANCE, DSA COMPOUNDS, KINASE, DFG-ASP- OUT, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO- ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE
2qlq:A (ILE441) to (TYR519) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN WITH COVALENT INHIBITOR RL3 | SRC KINASE DOMAIN, DRUG RESISTANCE, IRREVERSIBLE INHIBITOR, KOVALENT INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2qlq:B (THR440) to (TYR519) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN WITH COVALENT INHIBITOR RL3 | SRC KINASE DOMAIN, DRUG RESISTANCE, IRREVERSIBLE INHIBITOR, KOVALENT INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, LIPOPROTEIN, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHORYLATION, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
2qoh:A (ILE418) to (SER501) CRYSTAL STRUCTURE OF ABL KINASE BOUND WITH PPY-A | ABL, KINASE, INHIBITOR, TRANSFERASE
3gww:A (LYS398) to (HIS510) LEUCINE TRANSPORTER LEUT IN COMPLEX WITH S-FLUOXETINE | NEUROTRANSMITTER, TRANSMEMBRANE TRANSPORT, INTEGRAL MEMBRANE PROTEIN, ANTIDEPRESSANT, NSS, TRANSPORT PROTEIN, SYMPORT, TRANSMEMBRANE, TRANSPORT
1qcf:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY- SELECTIVE TYROSINE KINASE INHIBITOR | TYROSINE KINASE-INHIBITOR COMPLEX, DOWN-REGULATED KINASE, ORDERED ACTIVATION LOOP
2rgp:A (THR892) to (ARG973) STRUCTURE OF EGFR IN COMPLEX WITH HYDRAZONE, A POTENT DUAL INHIBITOR | KINASE DOMAIN, ALTERNATIVE SPLICING, ANTI-ONCOGENE, ATP- BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE, UBL CONJUGATION
2uw0:A (ALA218) to (ALA298) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4- CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE | TRANSFERASE/INHIBITOR, TRANSFERASE/INHIBITOR COMPLEX, CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION
2uw8:A (ALA218) to (ALA298) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 2-(4-CHLORO- PHENYL)-2-PHENYL-ETHYLAMINE | TRANSFERASE/INHIBITOR, CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION, TRANSFERASE/INHIBITOR COMPLEX
2v7a:A (ILE418) to (SER501) CRYSTAL STRUCTURE OF THE T315I ABL MUTANT IN COMPLEX WITH THE INHIBITOR PHA-739358 | KINASE, NUCLEUS, MYRISTATE, CYTOPLASM, MANGANESE, CELL ADHESION, METAL-BINDING, PROTO-ONCOGENE, TYROSINE-PROTEIN KINASE, CHROMOSOMAL REARRANGEMENT, TRANSFERASE, LIPOPROTEIN, POLYMORPHISM, CYTOSKELETON, MAGNESIUM, SH2 DOMAIN, SH3 DOMAIN, ATP-BINDING, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, PHOSPHORYLATION, KINASE INHIBITOR, T315I ABL MUTANT
2v7a:B (ILE418) to (SER501) CRYSTAL STRUCTURE OF THE T315I ABL MUTANT IN COMPLEX WITH THE INHIBITOR PHA-739358 | KINASE, NUCLEUS, MYRISTATE, CYTOPLASM, MANGANESE, CELL ADHESION, METAL-BINDING, PROTO-ONCOGENE, TYROSINE-PROTEIN KINASE, CHROMOSOMAL REARRANGEMENT, TRANSFERASE, LIPOPROTEIN, POLYMORPHISM, CYTOSKELETON, MAGNESIUM, SH2 DOMAIN, SH3 DOMAIN, ATP-BINDING, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, PHOSPHORYLATION, KINASE INHIBITOR, T315I ABL MUTANT
3hmi:A (ILE464) to (SER546) THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH 5-AMINO-3-{[4- (AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4- TRIAZOLE-1-CARBOTHIOAMIDE | TYROSINE KINASE, ABL, ABL2, ABELSON MURINE LEUKEMIA VIRAL ONCOGENE, ATP-BINDING, CELL ADHESION, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE, TYROSINE- PROTEIN KINASE, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC
4z55:A (SER1308) to (ASP1389) ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN COMPLEXED WITH PYRAZOLOPYRIMIDINE DERIVATIVE OF LDK378 | CATALYTIC DOMAIN, TRANSFERASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4z84:A (VAL219) to (ALA298) PKAB3 IN COMPLEX WITH PYRROLIDINE INHIBITOR 34A | INHIBITOR, PROTEIN KINASE, STRUCTURE-GUIDED, TRANSFERASE
1sm2:A (SER537) to (GLY619) CRYSTAL STRUCTURE OF THE PHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | PROTEIN KINASE, IMMUNOLOGY, TRANSFERASE
1sm2:B (SER537) to (ALA616) CRYSTAL STRUCTURE OF THE PHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | PROTEIN KINASE, IMMUNOLOGY, TRANSFERASE
1gzk:A (ALA330) to (HIS406) MOLECULAR MECHANISM FOR THE REGULATION OF PROTEIN KINASE B/ AKT BY HYDROPHOBIC MOTIF PHOSPHORYLATION | KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING
3iop:A (SER262) to (HIS339) PDK-1 IN COMPLEX WITH THE INHIBITOR COMPOUND-8I | PDK-1, INHIBITOR, ALTERNATIVE SPLICING, ATP-BINDING, CYTOPLASM, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3iw4:C (ASP520) to (ARG598) CRYSTAL STRUCTURE OF PKC ALPHA IN COMPLEX WITH NVP-AEB071 | KINASE, ATP-BINDING, CELL MEMBRANE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, PHORBOL-ESTER BINDING, PHOSPHOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ZINC-FINGER
4lm5:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH 2-{4-[(3-AMINOPROPYL) AMINO]QUINAZOLIN-2-YL}PHENOL (RESULTING FROM DISPLACEMENT OF SKF86002) | CO-CRYSTALLIZATION, SKF86002, FLUORESCENCE, INHIBITOR SCREENING, KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vry:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR 4-AMINO-5-(4-PHENOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL- CYCLOPENTANE | TYROSINE KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs0:A (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR N-[4-(4-AMINO-7-CYCLOPENTYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL) PHENYL]BENZAMIDE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs0:B (THR440) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRROLO-PYRIMIDINE INHIBITOR N-[4-(4-AMINO-7-CYCLOPENTYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL) PHENYL]BENZAMIDE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3vs6:B (ILE441) to (PHE519) CRYSTAL STRUCTURE OF HCK COMPLEXED WITH A PYRAZOLO-PYRIMIDINE INHIBITOR TERT-BUTYL {4-[4-AMINO-1-(PROPAN-2-YL)-1H-PYRAZOLO[3,4- D]PYRIMIDIN-3-YL]-2-METHOXYPHENYL}CARBAMATE | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4m0y:A (SER537) to (SER618) CRYSTAL STRUCTURE OF ITK IN COMPLEX WITH COMPOUND 1 [4- (CARBAMOYLAMINO)-1-(NAPHTHALEN-1-YL)-1H-PYRAZOLE-3-CARBOXAMIDE] | KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5aa8:A (LYS1309) to (ASP1389) STRUCTURE OF C1156Y,L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12- FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H- 8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE). | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR, MUTANT
5aaa:A (SER1308) to (ASP1389) STRUCTURE OF L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR, MUTANT
1uu3:A (SER262) to (HIS339) STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531 | PROTEIN KINASE, PKB, PDK1, INHIBITOR, LY333531, DIABETES, CANCER, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE
2x7o:C (GLU394) to (GLY500) CRYSTAL STRUCTURE OF TGFBRI COMPLEXED WITH AN INDOLINONE INHIBITOR | KINASE, TRANSFERASE, GLYCOPROTEIN
4mta:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM-1 KINASE DOMAIN IN COMPLEX WITH 2-METHYL-5- PHENYLFURAN-3-CARBOXYLIC ACID | SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, TRANSFERASE
1jqh:A (THR1190) to (ILE1266) IGF-1 RECEPTOR KINASE DOMAIN | PROTEIN KINASE FOLD, TRANSFERASE
1jqh:B (THR1190) to (ILE1266) IGF-1 RECEPTOR KINASE DOMAIN | PROTEIN KINASE FOLD, TRANSFERASE
1jqh:C (THR1190) to (ILE1266) IGF-1 RECEPTOR KINASE DOMAIN | PROTEIN KINASE FOLD, TRANSFERASE
2xj0:A (GLY220) to (HIS287) PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-4 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN | PHOSPHORYLATION, TRANSFERASE
4mxo:A (ILE441) to (TYR519) HUMAN SRC KINASE BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mxo:B (ILE441) to (TYR519) HUMAN SRC KINASE BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4mxy:B (ILE441) to (TYR519) SRC M314L T338M DOUBLE MUTANT BOUND TO KINASE INHIBITOR BOSUTINIB | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4n6y:A (ARG221) to (HIS287) PIM1 COMPLEXED WITH A PHENYLCARBOXAMIDE | KINASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3zo4:A (ALA218) to (ALA298) THE SYNTHESIS AND EVALUATION OF DIAZASPIROCYCLIC PROTEIN KINASE INHIBITORS | TRANSFERASE-INHIBITOR COMPLEX
3jy0:A (ARG221) to (HIS287) DISCOVERY OF 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONES AS POTENT, HIGHLY SELECTIVE AND ORALLY BIOAVAILABLE PIM KINASES INHIBITORS | PIM-1, ALTERNATIVE INITIATION, ATP-BINDING, CELL MEMBRANE, CYTOPLASM, KINASE, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
3k5v:A (ILE437) to (SER519) STRUCTURE OF ABL KINASE IN COMPLEX WITH IMATINIB AND GNF-2 | KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
3k5v:B (ILE437) to (THR514) STRUCTURE OF ABL KINASE IN COMPLEX WITH IMATINIB AND GNF-2 | KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, ONCOGENE, SH2 DOMAIN, TRANSFERASE, TYROSINE-PROTEIN KINASE
1xws:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN | PIM1, KINASE, CANCER, LEUKEMIA, TRANSFERASE
4otw:A (THR870) to (ALA950) HER3 PSEUDOKINASE DOMAIN BOUND TO BOSUTINIB | RECEPTOR TYROSINE KINASE, PSEUDOKINASE, BOSUTINIB, MEMBRANE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5d10:A (ILE441) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH RL236 | KINASE INHIBITOR, DRUG RESISTANCE, TRANSFERASE
5d10:B (THR440) to (TYR519) KINASE DOMAIN OF CSRC IN COMPLEX WITH RL236 | KINASE INHIBITOR, DRUG RESISTANCE, TRANSFERASE
1yds:E (ALA218) to (ALA298) STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5- ISOQUINOLINESULFONAMIDE | PHOSPHOTRANSFERASE, TRANSFERASE, CAMP, PHOSPHORYLATION, ISOQUINOLINE SULFONAMIDE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5da3:A (SER365) to (THR445) CRYSTAL STRUCTURE OF PTK6 KINASE DOMAIN WITH INHIBITOR | PTK6, BRK, COMPLEX, INHIBITOR, KINASE, TRANSFERASE, IMIDAZO PYRAZIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1yol:A (ILE443) to (TYR521) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN IN COMPLEX WITH CGP77675 | PROTEIN TYROSINE KINASE, TRANSFERASE
1yol:B (THR442) to (TYR521) CRYSTAL STRUCTURE OF SRC KINASE DOMAIN IN COMPLEX WITH CGP77675 | PROTEIN TYROSINE KINASE, TRANSFERASE
3ag9:B (VAL219) to (ALA298) COMPLEX OF PKA WITH THE BISUBSTRATE PROTEIN KINASE INHIBITOR ARC-1012 | PKA, PROTEIN KINASE A, BISUBSTRATE INHIBITOR, ARC-1012, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
3agm:A (ALA218) to (ALA298) COMPLEX OF PKA WITH THE BISUBSTRATE PROTEIN KINASE INHIBITOR ARC-670 | PKA, PROTEIN KINASE A, BISUBSTRATE, BISUBSTRATE INHIBITOR, ARC-670, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3l9p:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF THE ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | KINASE DOMAIN, ATP-BINDING, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE
3lcs:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF THE ANAPLASTIC LYMPHOMA KINASE CATALYTIC DOMAIN | KINASE DOMAIN, ATP-BINDING, GLYCOPROTEIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, PROTO-ONCOGENE, RECEPTOR, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TRANSFERASE
3amb:A (ALA218) to (ALA298) PROTEIN KINASE A SIXFOLD MUTANT MODEL OF AURORA B WITH INHIBITOR VX- 680 | PKA, PROTEIN KINASE A, SURROGATE, VX-680, MK-0457, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4asz:A (THR747) to (SER830) CRYSTAL STRUCTURE OF APO TRKB KINASE DOMAIN | TRANSFERASE, TRKA, TRKB
4at3:A (THR747) to (SER830) CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH CPD5N | TRANSFERASE
4at5:A (THR747) to (SER830) CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH GW2580 | TRANSFERASE
4aw0:A (SER262) to (HIS339) HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH ALLOSTERIC COMPOUND PS182 BOUND TO THE PIF-POCKET | TRANSFERASE, ALLOSTERIC REGULATION, ALLOSTERIC SITE, PHOSPHORYLATION, AGC PROTEIN KINASE
4axa:A (VAL219) to (ALA298) STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1S)-2-AMINO-1-( 4-CHLOROPHENYL)-1-(4-(1H-PYRAZOL-4-YL)PHENYL)ETHAN-1-OL | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3lvp:B (THR1190) to (ILE1266) CRYSTAL STRUCTURE OF BISPHOSPHORYLATED IGF1-R KINASE DOMAIN (2P) IN COMPLEX WITH A BIS-AZAINDOLE INHIBITOR | PROTEIN KINASE, TYROSINE KINASE, TYROSINE PHOSPHORYLATION, PROTEIN- SUBSTRATE COMPLEX, TRANSFERASE
5e7r:A (LYS209) to (PRO292) CRYSTAL STRUCTURE OF TL10-81 BOUND TO TAK1-TAB1 | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7/TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3miy:A (SER537) to (GLY619) X-RAY CRYSTAL STRUCTURE OF ITK COMPLEXED WITH SUNITINIB | HELIX C-IN, TRANSFERASE
3bgp:A (GLY220) to (HIS287) HUMAN PIM-1 COMPLEXED WITH A BENZOISOXAZOLE INHIBITOR VX1 | KINASE INHIBITOR PHOSPHORYLATION, ALTERNATIVE INITIATION, ATP-BINDING, CYTOPLASM, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE
5eyc:A (THR1261) to (THR1343) CRYSTAL STRUCTURE OF C-MET IN COMPLEX WITH NAPHTHYRIDINONE INHIBITOR 5 | PHOSPHOTRANSFERASE, INHIBITOR, CANCER, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4r1v:A (THR1262) to (THR1343) IDENTIFICATION AND OPTIMIZATION OF PYRIDAZINONES AS POTENT AND SELECTIVE C-MET KINASE INHIBITORS | PROTEIN KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4bzo:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH A PYRROLO- PYRAZINONE INHIBITOR | PIM1, ATP BINDING, KINASE INHIBITOR, TRANSFERASE
4rfy:A (LYS577) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 6- (DIMETHYLAMINO)-2-[2-(HYDROXYMETHYL)-3-[1-METHYL-5-[[5-(MORPHOLINE-4- CARBONYL)-2-PYRIDYL]AMINO]-6-OXO-3-PYRIDYL]PHENYL]-3,4- DIHYDROISOQUINOLIN-1-ONE | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4rg0:A (SER576) to (GLU657) CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-[8-FLUORO-2- [2-(HYDROXYMETHYL)-3-[1-METHYL-5-[[5-(4-METHYLPIPERAZIN-1-YL)-2- PYRIDYL]AMINO]-6-OXO-3-PYRIDYL]PHENYL]-1-OXO-3,4-DIHYDROISOQUINOLIN- 6-YL]-2-METHYL-PROPANENITRILE | TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4ccb:A (LYS1309) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 3-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)-5-(5-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2-AMINE | TRANSFERASE, RECEPTOR TYROSINE KINASE, ANAPLASTIC LYMPHOMA KINASE, INHIBITOR
4cd0:A (LYS1309) to (ASP1389) STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL) PHENYL)ETHOXY)PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPANE-1,2-DIOL | TRANSFERASE, RECEPTOR TYROSINE KINASE, INHIBITOR
3nuu:A (SER262) to (HIS339) PHOSPHOINOSITIDE-DEPENDENT KINASE-1 (PDK1) WITH FRAGMENT11 | KINASE DOMAIN, TRANSFERASE
4rrv:A (SER262) to (HIS339) CRYSTAL STRUCTURE OF PDK1 IN COMPLEX WITH ATP AND PIFTIDE | PROTEIN KINASE, PIFTIDE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4cli:A (LYS1309) to (ASP1389) STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15 -OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H) (2,5,11)BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE). | TRANSFERASE, INHIBITOR
3d94:A (THR1160) to (ILE1236) CRYSTAL STRUCTURE OF THE INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE IN COMPLEX WITH PQIP | IGF1RK, RECEPTOR TYROSINE KINASE, PQIP, INHIBITOR, ATP- BINDING, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, TRANSMEMBRANE, TYROSINE- PROTEIN KINASE
3dk7:A (ILE418) to (ILE502) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
3dk7:B (ILE418) to (SER500) CRYSTAL STRUCTURE OF MUTANT ABL KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE FRAGMENT | DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, ALTERNATIVE SPLICING, ATP-BINDING, CELL ADHESION, CHROMOSOMAL REARRANGEMENT, CYTOPLASM, CYTOSKELETON, KINASE, LIPOPROTEIN, MAGNESIUM, MANGANESE, METAL-BINDING, MYRISTATE, NUCLEOTIDE- BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SH2 DOMAIN, SH3 DOMAIN, TRANSFERASE
4d2t:B (GLU189) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN, KINASE
4d2t:D (GLU189) to (MET264) STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS | TRANSFERASE, FRAGMENT BASED DRUG DESIGN, KINASE
3dpk:A (VAL834) to (GLU912) CFMS TYROSINE KINASE IN COMPLEX WITH A PYRIDOPYRIMIDINONE INHIBITOR | RECEPTOR TYROSINE KINASE, KINASE-INHIBITOR COMPLEX, ATP- BINDING, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, KINASE, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, POLYMORPHISM, PROTO-ONCOGENE, RECEPTOR, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, ALTERNATIVE SPLICING, CHROMOSOMAL REARRANGEMENT, CRANIOSYNOSTOSIS, DISEASE MUTATION, DWARFISM, HEPARIN-BINDING, KALLMANN SYNDROME
3ori:A (ARG196) to (GLY279) MYCOBACTERIUM TUBERCULOSIS PKNB KINASE DOMAIN L33D MUTANT (CRYSTAL FORM 1) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, KINASE, SIGNAL TRANSDUCTION, TRANSFERASE
3ori:B (ARG196) to (GLY279) MYCOBACTERIUM TUBERCULOSIS PKNB KINASE DOMAIN L33D MUTANT (CRYSTAL FORM 1) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, KINASE, SIGNAL TRANSDUCTION, TRANSFERASE
3ori:D (ARG196) to (GLY279) MYCOBACTERIUM TUBERCULOSIS PKNB KINASE DOMAIN L33D MUTANT (CRYSTAL FORM 1) | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, KINASE, SIGNAL TRANSDUCTION, TRANSFERASE
5he3:A (ALA372) to (SER450) BOVINE GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG224411 | RGS, KINASE, PH, WD-40, INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4uja:A (VAL219) to (ALA298) PROTEIN KINASE A IN COMPLEX WITH AN INHIBITOR | TRANSFERASE
4f1m:A (THR1211) to (LEU1292) CRYSTAL STRUCTURE OF THE G1179S ROCO4 KINASE DOMAIN BOUND TO APPCP FROM D. DISCOIDEUM. | PROTEIN KINASE, LRRK2, ROCO, KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, SIGNALING PROTEIN
3qfv:A (GLY259) to (HIS339) MRCK BETA IN COMPLEX WITH TPCA-1 | PROTEIN KINASE DOMAIN OF MRCK BETA IN COMPLEX WITH TPCA-1, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3qlf:A (THR440) to (TYR519) CRYSTAL STRUCTURE OF THE L317I MUTANT OF THE C-SRC TYROSINE KINASE DOMAIN COMPLEXED WITH PYRAZOLOPYRIMIDINE 5 | C-SRC L317I MUTANT, TYROSINE KINASE, TRANSFERASE, PYRAZOLOPYRIMIDINE 5
4fl2:A (SER550) to (VAL633) STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYK ACTIVATION SWITCH | TRANSFERASE, PROTEIN KINASE
4fl3:A (SER551) to (VAL633) STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYK ACTIVATION SWITCH | TRANSFERASE, PROTEIN KINASE
4fod:A (SER1308) to (ASP1389) CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH ACYLIMINOBENZIMIDAZOLE INHIBITOR 36 | RECEPTOR TYROSINE KINASE, INHIBITOR, CRIZOTINIB, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, TRANSFERASE-INHIBITOR COMPLEX
4fvr:A (ALA733) to (LEU808) CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN MUTANT V617F (MG- ATP-BOUND FORM) | JANUS PROTEIN KINASE, PSEUDOKINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE
5kzi:A (ARG221) to (HIS287) CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH AN IMIDAZOPYRIDAZINE INHIBITOR. | TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5l2t:A (ALA197) to (GLN301) THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND RIBOCICLIB. | CYCLIN-DEPENDENT KINASE, KINASE INHIBITOR, KINASE SELECTIVITY, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX